HIRAOKA Masayasu 平岡昌和

Researcher Number	80014281
External Links
Affiliation (based on the past Project Information) *help	2002 – 2004: 東京医科歯科大学, 難治疾患研究所, 教授 1987 – 2000: 東京医科歯科大学, 難治疾患研究所, 教授 1994: Medical Research Institute, Tokyo Medical and Dental University, Department of C, 教授 1993 – 1994: 東京医科歯科大学, 難治研, 教授 1987: 東京大学, 難治疾患研究所, 教授 1986: Tokyo Medical and Dental University, Medical Research Institute, 難治疾患研究所, 教授
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Thoracic surgery
Keywords	Principal Investigator パッチ・クランプ法 / QT延長症候群 / 活動電位再分極相 / 単一心室筋細胞 / ATP感受性K^+チャネル / チャネル遺伝子 / 一過性外向き電流 / Ca^<2+>放出 / Ca^<2+>電流 / Transient outward current … More / ATP感受性Kチャネル / HERG Kチャネル / ADP / dominant negative suppression / 不活性化過程 / 心室筋活動電位 / コンピュ-タ・シミュレ-ション / 膜電流 / 不整脈のシミュレ-ション / Ca^<2+>チャネル / ト-センダニン / シタンジン / 特発性心室細動 / Ca感受性 / Ca遊離チャネル / Gap junction / 電気的リモデリング / 分化誘導 / Brugada症候群 / KvLQT1 / HERG / SCN5A / カテコラミン感受性多形心室頻拍 / ST上昇 / 単一心筋細胞 / 全細胞電流記録 / 遅延整流外向き電流 / Ca^<2+>流入 / 細胞内増加Ca^<2+> / 遅延外向きK^+電流 / Co^<2+> / 遅延整流K^+電流 / Single heart cells / Patch-clamp technique / Whole-cell current recordings / Delayed outward K^+ current / Ca^<2+>-influx / Increased internal Ca^<2+> / ATP感受性K^+チャネル蛋白 / クロマカリム / グリベンクラミド / 光アフィニティラベル法 / ATP結合能 / ニコランジル / 単一チャネル電流 / グリベンクロマイド / K^+チャネル蛋白 / ATP-sensitive K^+ channel protein / Cromakalim / Glibenclamide / photoaffinity labeling method / ATP binding capacity / Nicorandil / I群抗不整脈薬 / Na^+チャネル / チャネル状態親和性 / ブロック動態と様式 / 単離心室筋細胞 / 使用依存性ブロック / イオン化型と非イオン化型薬物 / チャネル抑制の速度 / 荷電型と非荷電型薬物 / Na^+チャネル抑制の動態 / 心筋Na^+チャネル / 抗不整脈薬 / イオン化型と非イオン化型薬剤 / 活性化状態親和性 / 不活性化状態親和性 / パッチ・クラプ法 / class I antiarrhythmic drugs / Na^+ channel / State-dependent affinity / Blocking kinetics and modes / ventricular myocytes / patch-clamp technique / 筋小胞体 / リアノジン受容体チャネル / 人工脂質膜 / Cl-チャネル / リャノジン受容体チャネル / 小胞体 / 隣酸化 / Ryanodine receptor Ca^<2+> release channel / sarcoplasmic reticulum / artificial lipid bilayr / Cl-channel / 蛋白リン酸化 / L型Caチャネル / Ca放出リヤノジン受容体 / Caチャネル / リン酸化部位 / α受容体 / cGMP / Ca活性化Clチャネル / protein phosphorylation / L-type Ca^<2+> channel / ATP-sensitive / K^+ channel / HERG K^+ channel / Ca^<2+> -activated Cl^- -channel / Ryanodine receptor channel / チャネルのrundown / 細胞内ATP / アクチン細骨格 / アデノシン / ロテイン・カイネース / プロティン・カイネース / ATPk感受性Kチャネル / 細胞内活性化因子 / チャネル活性の失活(rundown) / ATPの加水分解 / 再活性化 / アクチン細胞骨格 / ATP-sensitive K^+ channel / rundown of the channel activity / intracellular ATP / actin cytoskeleton / adenosine / protein kinase C / 変異チャネル / 活性化過程 / 不活性化の促進 / K電流抑制 / 再分極 / 電位センサー / 女性ホルモン / アシドージス / 遅延整流K電流 / 内向き整流 / 脱活性化の促進 / 遺伝子異変 / long QT syndrome / HERG K channels / mutant channels / activation process / acceleration of inactivation / K current suppression / repolarization / Triggered-activity(誘発活動) / 遅延後脱分極 / 一過性内向き電流 / 【Ba^(2+)】イオン / アコニチン / 不整脈の発生機序 / Triggered-activity / Delayed afterdepolarization / Transient inward current / Barium ion / Aconitine / 心室再分極相 / パッチクランプ法 / 活動電位再分極 / 単ー心室筋細胞 / Ca^<2+>ー非感受性一過外向き電流 / Ca^<2+>ー感受性 / 心室筋再分極相 / Single ventricular myocyte / Patch clamp method / Inactivation process … More Except Principal Investigator クロライド電流 / 膜電位感受性色素 / クロライドチャネル / 筋小胞体 / Caチャネル / ATP感受性Kチャネル / ランダウン / CFTR / BHK細胞 / single channel recording / クローン発現系 / 興奮収縮連関 / パッチクランプ法 / GTP結合蛋白質 / エクオリン / X線回析法 / イオンチャネル / ミトコンドリア / 心肥大 / 心不全 / reentrant tachycardia / rabbit right atrium / microelectrode method / 心筋興奮収縮連関 / Ca^<2+>チャンネル / Na^+チャンネル / 受容体 / 心筋収縮蛋白質 / 燐酸化 / 細胞内Ca^<2+>動態 / 筋小胞体Ca^<2+>輸送 / ATP感受性カリウム電流 / 心筋虚血 / イオン感受性電極 / アミロライド / 交感神経緊張 / 興奮伝播マッピング / リゾフォスファチジ-ルコリン / 短鎖アシルカルニチン / トリプシン / プリン作動性チャネル / 伸展活性化チャネル / 細胞内カルシウム濃度 / 洞結節異常自動能 / 異方向性伝導 / イオン透過性 / ATP通過 / 人工脂質膜 / 電気生理学 / アデニンヌクレオチド / イオンチャンネル / アセチルコリン・リセプター / ホスホランハン / アセチルコリン / リセプター / ホスホランバン / 心筋特異的遺伝子発現 / 転写調節機構 / ホメオボックス遺伝子 / 肥大型心筋症 / ミトコンドリア心筋症 / 拡張型心筋症 / QT延長症候群 / 心筋細胞 / 遺伝子発現 / 心筋症 / BNP / カリウムチャンネル / アンギオテンシン / cardio-specific gene expression / cardiac hypertrophy / mechanism of transcriptional regulation / homeobox gene / hypertvophic cardiomyopathy / mitochondrial cardiomyopathy / dilated cardiomyopathy / long QT syndrome / antiarrhythmic agent / proarrhythmia / microelectrode / bipolar electrode / Antiarrhythmic agent / reentrrat tachycardia / reentrat tachycardia / antiarrhythmic drug / proaarrhythmia / effective refractroy period / echo zone / aggravation of existing arrhythmias / 不整脈 / HERGチャネル / Kチャネル / 心筋症ハムスター / 致死性不整脈 / リモデリング / 遺伝子異常 / HERG / KCNQ1 / Long QT症候群 / チャネル輸送 / チャネルリモデリング / 一過性外向きKチャネル / L型Caチャネル / 蛋白チロシン燐酸化 / チャネル蛋白発現 / HERG電流密度減少 / 容積感受性クロールチャネル / ペースメーカーチャネル / 圧負荷 / Ion Channel / Arrhythmia / HERG Channel / Ca Channel / K Channel / Cardiomyopathic hamster / Lethal Arrhtymia / Remodeling / Heart Failure Less

致死性不整脈発症の分子基盤に関する調査・研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
心臓血管系におけるチャネル病の発症と成因に関する調査・研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ ChannelsPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Meducal and Dental University
BHK細胞へ発現させたL型Caチャネルの機能調節(2):燐酸化反応とprotein targeting
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugs
- Principal Investigator
  
  SAWANOBORI Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institute, Tokyo Medical and Dental University
BHK細胞へ発現させた心筋L型Caチャネルの機能調節とサブユニット構造
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Modulatory mechanisms of cardiac ion channels.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.Principal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
Cardio-Specific Gene Expression and Genetic Analysis of Myocardial Disorders
- Principal Investigator
  
  YAZAKI Yoshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordingsPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical & Dental University, Medical Research Institute
心筋の異常興奮と伝導のメカニズム
- Principal Investigator
  
  有田真
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学
Development of a ligand for purification of the ATP-sensitive K^+ channe proteinPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  TADA Michihiko
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発Principal Investigator
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for ArrhythmogenesisPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institution, Tokyo Medical and Dental University
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  多田道彦
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心筋細胞の興奮・収縮機構
- Principal Investigator
  
  多田道彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Study of the outward current systems of mammalian ventricular muscle cells in relation to the genesis of rhythm disturbancesPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
The study of the mechanism and characteristics of triggered-activityPrincipal Investigator
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2004 2003 2002

All Journal Article

[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.2004
- Author(s)
  Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano, Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 27194-27198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.2004
- Author(s)
  E.Yanagida, S.Shoji, Y.Hirayama, F.Yoshikawa, K.Otsu, H.Uematsu, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Hiraoka M, et al.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004
- Author(s)
  T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 27-32
- NAID
  10013054366
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] The effects of K+ channel modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 189-195
- NAID
  10013054366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 189-195
- NAID
  10013294757
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia2004
- Author(s)
  Ueda K, Hiraoka M, Kimura A, et al.
- Journal Title
  
  J.Biol.Chem 279
  
  Pages: 27194-27198
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 185-195
- NAID
  10013294757
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Reentrant tachycardias in pulmonary veins of patients with paroxysmal atrial fibrillation.2003
- Author(s)
  Takahashi Y, Ieska Y, Takahashi A, Goya M, Kobayashi K, Fujiwara H, Hiraoka M.
- Journal Title
  
  Cardiovasc Electrophysiol 14
  
  Pages: 927-932
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003
- Author(s)
  Kocic I, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  Basic Res Cardiol 98
  
  Pages: 367-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ST segment elevation in the Brugada syndrome.2003
- Author(s)
  Nishizaki M, Sakurada H, Ashikaga T, Yamawake N, Fujii H, Arita M, Isobe M, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 14
  
  Pages: 243-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of recombinant KCNQ1/KCNE1 K channels (I_<KS>) by intracellular Na and its implications on action potential repolarization.2003
- Author(s)
  Orikabe M, Hirano Y, Isobe M, Hiraoka M.
- Journal Title
  
  Jpn.J.Physiol. 53
  
  Pages: 417-425
- NAID
  10012733004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Reentrant tachycardias in pulmonary veins of patients with paroxysmal atrial fibrillation.2003
- Author(s)
  Takahashi Y, Ieska Y, Takahashi A, Goya M, Kobayashi K, Fujiwara H, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 14
  
  Pages: 927-932
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Rate-dependent changes in action potential durations and membrane currents in hamster ventricular myocytes.2002
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  Pflugers Arch 443
  
  Pages: 353-361
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure lowering without affecting heart weight increase in rats with abdominal aortic banding.2002
- Author(s)
  Hiramatsu M, Furukawa T, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 39
  
  Pages: 866-874
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.2002
- Author(s)
  Nishizaki M, Ashikaga T, Yamawake N, Fujii H, Arita M, Sumitomo N, Sakurada H, Hiraoka M
- Journal Title
  
  Circ J 66
  
  Pages: 35-40
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] High incidence of device-related and lead-related complications in the dual-chamber implantable cardioverter defibrillator compared with the single-chamber version.2002
- Author(s)
  Takahashi T, Bhandari AK, Watanuki M, Cannom DS, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 746-750
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.2002
- Author(s)
  Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A.
- Journal Title
  
  Cardiovasc Res 53
  
  Pages: 348-354
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure Class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardias2002
- Author(s)
  Igawa M, Aonuma K, Okamoto Y, Hiroe M, Hiraoka M, Isobe M.
- Journal Title
  
  J Cardiovasc Pharmacol 40
  
  Pages: 735-742
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Opening of KATP channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty.2002
- Author(s)
  Ashikaga T, Nishizaki M, Arita M, Yamawake N, Fujii H, Kishi Y, Isobe M, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 469-472
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Opening of KATP channel attenuates the increase in QT dispersion produced by the first balloon inflation during coronary angioplasty2002
- Author(s)
  Ashikaga T, Nishizaki M, Arita M, Yamawake N, Fujii H, Kishi Y, Isobe M, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 469-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Electrical connections between pulmonary veins. Implications for ostial ablation of pulmonary veins in patients with paroxyxmal atrial fibrillation.2002
- Author(s)
  Takahashi A, Iesaka Y, Takahashi Y, Takahashi R, Kobayashi K, Takagi K, Kuboyama O, Nishimori T, Takei H, Amemiya H, Fujiwara H, Hiraoka M.
- Journal Title
  
  Circulation 105
  
  Pages: 2998-3003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Electrical connection between left superior and inferior pulmonary veins in a patient with paroxysmal atrial fibrillation.2002
- Author(s)
  Takahashi Y, Iesaka Y, Takahashi A, Hiraoka M.
- Journal Title
  
  J Cardiovasc Electrophysiol 13
  
  Pages: 490-492
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] High incidence of device-related and lead-related complications in the dual-chamber implantable cardioverter defibrillator compared with the single-chamber version.2002
- Author(s)
  Takahashi T, Bhandari AK, Watanuki M, Cannom DS, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66:
  
  Pages: 746-750
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.2002
- Author(s)
  Nishizaki M, Ashikaga T, Yamawake N, Fujii H, Arita M, Sumitomo N, Sakurada H, Hiraoka M.
- Journal Title
  
  Circ J 66
  
  Pages: 35-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Moving dipole analysis of normal and abnormal ventricular activation by magnetocardiography.2002
- Author(s)
  Hiyoshi Y, Sakurada H, Izumida N, Kawano S, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Electrocardiol 35
  
  Pages: 105-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure Class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardias.2002
- Author(s)
  Igawa M, Aonuma K, Okamoto Y, Hiroe M, Hiraoka M, Isobe M.
- Journal Title
  
  J Cardiovasc Pharmacol 40
  
  Pages: 735-742
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404

1. HIRANO Yuji (00181181)

# of Collaborated Projects: 9 results

# of Collaborated Products: 17 results
2. KAWANO Seiko (00177718)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
3. SAWANOBORI Tohru (00014217)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. TADA Michihiko (90093434)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 頴原嗣尚 (50037446)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 外山淳治 (20023658)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 遠藤政夫 (40004668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 有田真 (60037364)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 神野耕太郎 (40025630)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 小川聡 (90124940)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 木村彰方 (60161551)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. HORIKAWA Saburo (10127136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 西勝英 (00040220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 堀江稔 (90183938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 野間昭典 (00132738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. YAZAKI Yoshio (20101090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAGAI Ryozo (60207975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKAO Kazuwa (00172263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SASAYAMA Shigetake (70109007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KUNIYASU Akihikko (90241348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 松原一郎 (90010040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 渡部良夫 (70084572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大津欣也 (20294051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 児玉逸雄 (30124720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 岡田泰伸 (10025661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 相澤義房 (50143780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 蒔田直昌 (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 山口正人 (90313650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 宇井理生 (50001037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 芳賀達也 (30011646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 松原弘明 (10239072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 川口秀明 (70161297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. CORONAD Roberts

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. HARTZELL Criss

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. FOZZARD Harry A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 施玉りゃん

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 徐科

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. CORONADO Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRAOKA Masayasu 平岡 昌和

Research Projects

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Co-Researchers

致死性不整脈発症の分子基盤に関する調査・研究Principal Investigator

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The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator

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心臓血管系におけるチャネル病の発症と成因に関する調査・研究Principal Investigator

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Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ ChannelsPrincipal Investigator

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Modulatory mechanisms of cardiac ion channels.Principal Investigator

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Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.Principal Investigator

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Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.Principal Investigator

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心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究Principal Investigator

Principal Investigator

HIRAOKA Masayasu 平岡昌和