SAWANOBORI Tohru 沢登徹

Researcher Number	00014217
Affiliation *help	1997 – 2000 : 東京医科歯科大学, 難治疾患研究所, 教授 1989 – 1997 : 東京医科歯科大学, 難治疾患研究所, 助教授 1990 : 東京医科歯科大学難治疾患研究所, 助教授 1987 : 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Anesthesiology/Resuscitation studies / General physiology
Keywords	Principal Investigator reentrant tachycardia / microelectrode method / rabbit right atrium / reentrat tachycardia / streptozotocin / アコニチン細動 / 一過性外向き電流 / 活動電位持続時間 / whole cell patch clamp / effective refractroy period … More Except Principal Investigator 致死性不整脈 / パッチ・クランプ法 / 活動電位再分極相 / 心室筋Na電流モデル / 3次元心臓興奮モデル / スルホニルウレア受容体 / propofol / グリベンクラミド / 光アフィニティラベル / sinus node / ATP感受性Kチャネル / 心室筋再分極モデル / ADP / S100 / 心臓遅延電位 / 麻酔薬 / 一過性外向き電流 / アクチン細骨格 / CD36 / 膜電流 / Patch-clamp technique / ト-センダニン / K-ATPチャネル / 洞結節ペ-スメ-カ電流 / 細胞間結合 / 使用依存性ブロック / ロテイン・カイネース / スカベンジャー受容体 / 抗不整脈薬 / State-dependent affinity / 不活性化状態親和性 / イオン化型と非イオン化型薬剤 / ATP感受性K^+チャネル / 心筋保護 / 不均一な興奮性 / Na^+ channel / イオン化型と非イオン化型薬物 / class I antiarrhythmic drugs / 光学的測定 / 洞結節ペースメーカ電流 / I群抗不整脈薬 / ATPの加水分解 / 心電図シミュレ-ション / Co^<2+> / 致死的不整脈 / Whole-cell current recordings / シタンジン / 虚血とKイオン / inhomogeneous excitability / ischemia and K^+ accumulation / 単一心筋細胞 / 興奮のリエントリ- / アクチン細胞骨格 / protein kinase C / patch-clamp technique / Ca^<2+>放出 / re-entry of excitation / コンピュ-タ・シミュレ-ション / プロティン・カイネース / ATPk感受性Kチャネル / Ca^<2+>-influx / Ca^<2+>電流 / 遅延外向きK^+電流 / 興奮伝導異方向性 / イオン電流解析 / Na^+チャネル抑制の動態 / intracellular ATP / ホモロジー / 細胞内活性化因子 / リエントリ- / チャネル状態親和性 / 電気生理学 / 細胞内増加Ca^<2+> / rundown of the channel activity / 単離心室筋細胞 / 右心房 / マクロファージ / 活性化状態親和性 / modulation of ventricular repolarization / チャネル活性の失活(rundown) / 心室細動シミュレーション / 心室再分極過程の修飾 / 心電図微小電位 / 遅延整流K^+電流 / Ca^<2+>流入 / 膜電位感受性色素 / Kチャネルブロッカー / Increased internal Ca^<2+> / チャネル抑制の速度 / 心室細動 / adenosine / Na^+チャネル / actin cytoskeleton / Single heart cells / 心筋興奮 / ブロック動態と様式 / 不整脈のシミュレ-ション / 電気ショック / Ca^<2+>チャネル / 遅延整流外向き電流 / 心室細動シミュレ-ション / 心室筋活動電位 / 旋回性興奮 / 単一心室筋細胞 / 心筋 / 再活性化 / パッチ・クラプ法 / 心筋再分極 / 細胞内ATP / 心筋Na^+チャネル / ventricular myocytes / 全細胞電流記録 / 心筋脱分極 / Blocking kinetics and modes / プレコンディショニング / チャネルのrundown / Delayed outward K^+ current / アデノシン / ATP-sensitive K^+ channel / Transient outward current / 荷電型と非荷電型薬物 / 三次元解析 Less

Research Projects
(18results)
Co-Researchers
(20People)

Mechanisms of Anesthetics-induced preconditioning in Isolated Heart
- Principal Investigator
  
  SAKAI Fmio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo medical and dental university
新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugsPrincipal Investigator
- Principal Investigator
  
  SAWANOBORI Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institute, Tokyo Medical and Dental University
新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
波長スペクトルの異なる膜電位感受性色素の二重染色による興奮旋回の光学的三次元解析
- Principal Investigator
  
  廣田秋彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
異常状況下でのI_K電流ブロッカーの頻度依存性効果Principal Investigator
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
致死性不整脈の成立機序
- Principal Investigator
  
  TOYAMA Junji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagoya University
Mgイオンによる致死性不整脈防止機序に関する研究Principal Investigator
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレーション
- Principal Investigator
  
  外山淳治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究
- Principal Investigator
  
  平岡昌和
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレ-ション
- Principal Investigator
  
  外山淳治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical & Dental University, Medical Research Institute
心筋興奮の発生と伝導のシミュレ-ション
- Principal Investigator
  
  TOYAMA Junji
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya University
糖尿病ラットにおける心筋K^+電流のATP感受性とその変化Principal Investigator
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institution, Tokyo Medical and Dental University
糖尿病における心筋変性の成因に関する研究Principal Investigator
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University

1. HIRAOKA Masayasu (80014281)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
2. HIRANO Yuji (00181181)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
3. TOYAMA Junji (20023658)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
4. INOUE Toshimichi (30028401)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
5. 安井昭二 (20023781)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
6. 春見建一 (00102335)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
7. 鈴木良次 (80013811)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. 中山仁 (70088863)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. 國安明彦 (90241348)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. 甲斐広文 (30194658)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
11. HORIKAWA Saburo (10127136)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. TOMOIKE Hitonobu (90112333)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. MASHIMA Saburo (30010333)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. KIYOSUE Tatsuto (90128348)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. SAKAI Fmio (80302868)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 入沢宏 (30033947)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 廣田秋彦 (50156717)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 佐藤容子 (70251501)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 施玉りゃん

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 徐科

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

SAWANOBORI Tohru 沢登 徹

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Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugsPrincipal Investigator

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異常状況下でのI_K電流ブロッカーの頻度依存性効果Principal Investigator

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Mgイオンによる致死性不整脈防止機序に関する研究Principal Investigator

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糖尿病ラットにおける心筋K^+電流のATP感受性とその変化Principal Investigator

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SAWANOBORI Tohru 沢登徹