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SAWANOBORI Tohru
沢登 徹
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Alternative Names
沢登 徹 サワノボリ トオル
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Researcher Number
00014217
Affiliation (based on the past Project Information)
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1997 – 2000: 東京医科歯科大学, 難治疾患研究所, 教授
1989 – 1997: 東京医科歯科大学, 難治疾患研究所, 助教授
1990: 東京医科歯科大学難治疾患研究所, 助教授
1987: 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine
/
General physiology
/
Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
reentrant tachycardia / rabbit right atrium / microelectrode method / streptozotocin / Diabetic rat / ATP sensitive K chennel / Lucifenn-Luciferase method / isolated ventricular myocyte / whole cell patch clamp / hypoglycemic sulphonylurea
…
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/ 致死性不整脈 / 撃発活動 / 早期後脱分極 / アコニチン細動 / Mg^<2+>イオン / 内向きhump電流 / Na活性型K電流 / I_K電流遮断薬 / 遅延整流K電流 / 逆頻度依存性 / 活動電位持続時間 / アチドーシス / Zuckerラット / ストレプトゾトシン / 一過性外向き電流 / antiarrhythmic agent / proarrhythmia / microelectrode / bipolar electrode / Antiarrhythmic agent / reentrrat tachycardia / reentrat tachycardia / antiarrhythmic drug / proaarrhythmia / effective refractroy period / echo zone / aggravation of existing arrhythmias
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Except Principal Investigator
パッチ・クランプ法 / 致死性不整脈 / 活動電位再分極相 / 心室筋Na電流モデル / 心室筋再分極モデル / 3次元心臓興奮モデル / 心臓遅延電位 / スルホニルウレア受容体 / グリベンクラミド / 光アフィニティラベル / ATP感受性Kチャネル / ADP / S100 / sinus node / propofol / 心室筋活動電位 / コンピュ-タ・シミュレ-ション / 膜電流 / 不整脈のシミュレ-ション / 心筋興奮 / イオン電流解析 / 心筋脱分極 / 心筋再分極 / 心電図シミュレ-ション / 心電図微小電位 / 致死的不整脈 / 単一心室筋細胞 / Ca^<2+>チャネル / ATP感受性K^+チャネル / ト-センダニン / シタンジン / 洞結節ペ-スメ-カ電流 / 心室細動シミュレ-ション / 洞結節ペースメーカ電流 / 心室細動シミュレーション / 膜電位感受性色素 / 旋回性興奮 / 右心房 / 光学的測定 / リエントリ- / 三次元解析 / 心筋 / K-ATPチャネル / ホモロジー / マクロファージ / スカベンジャー受容体 / CD36 / 単一心筋細胞 / 全細胞電流記録 / 一過性外向き電流 / 遅延整流外向き電流 / Ca^<2+>流入 / 細胞内増加Ca^<2+> / Ca^<2+>放出 / 遅延外向きK^+電流 / Co^<2+> / Ca^<2+>電流 / 遅延整流K^+電流 / Single heart cells / Patch-clamp technique / Whole-cell current recordings / Transient outward current / Delayed outward K^+ current / Ca^<2+>-influx / Increased internal Ca^<2+> / I群抗不整脈薬 / Na^+チャネル / チャネル状態親和性 / ブロック動態と様式 / 単離心室筋細胞 / 使用依存性ブロック / イオン化型と非イオン化型薬物 / チャネル抑制の速度 / 荷電型と非荷電型薬物 / Na^+チャネル抑制の動態 / 心筋Na^+チャネル / 抗不整脈薬 / イオン化型と非イオン化型薬剤 / 活性化状態親和性 / 不活性化状態親和性 / パッチ・クラプ法 / class I antiarrhythmic drugs / Na^+ channel / State-dependent affinity / Blocking kinetics and modes / ventricular myocytes / patch-clamp technique / 興奮のリエントリ- / 虚血とKイオン / 不均一な興奮性 / 心室再分極過程の修飾 / 心室細動 / 興奮伝導異方向性 / Kチャネルブロッカー / 電気ショック / 細胞間結合 / re-entry of excitation / ischemia and K^+ accumulation / inhomogeneous excitability / modulation of ventricular repolarization / チャネルのrundown / 細胞内ATP / アクチン細骨格 / アデノシン / ロテイン・カイネース / プロティン・カイネース / ATPk感受性Kチャネル / 細胞内活性化因子 / チャネル活性の失活(rundown) / ATPの加水分解 / 再活性化 / アクチン細胞骨格 / ATP-sensitive K^+ channel / rundown of the channel activity / intracellular ATP / actin cytoskeleton / adenosine / protein kinase C / 麻酔薬 / 電気生理学 / プレコンディショニング / 心筋保護
Less
Research Projects
(
18
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Mechanisms of Anesthetics-induced preconditioning in Isolated Heart
Principal Investigator
SAKAI Fmio
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Tokyo medical and dental university
新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関
Principal Investigator
中山 仁
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Kumamoto University
Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugs
Principal Investigator
Principal Investigator
SAWANOBORI Tohru
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Medical Research Institute, Tokyo Medical and Dental University
新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析
Principal Investigator
中山 仁
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Kumamoto University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
波長スペクトルの異なる膜電位感受性色素の二重染色による興奮旋回の光学的三次元解析
Principal Investigator
廣田 秋彦
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General physiology
Research Institution
Tokyo Medical and Dental University
異常状況下でのI_K電流ブロッカーの頻度依存性効果
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
致死性不整脈の成立機序
Principal Investigator
TOYAMA Junji
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Circulatory organs internal medicine
Research Institution
Nagoya University
Mgイオンによる致死性不整脈防止機序に関する研究
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレーション
Principal Investigator
外山 淳治
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究
Principal Investigator
平岡 昌和
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレ-ション
Principal Investigator
外山 淳治
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical & Dental University, Medical Research Institute
心筋興奮の発生と伝導のシミュレ-ション
Principal Investigator
TOYAMA Junji
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
糖尿病ラットにおける心筋K^+電流のATP感受性とその変化
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1989
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1989
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
Medical Research Institution, Tokyo Medical and Dental University
糖尿病における心筋変性の成因に関する研究
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1987
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
# of Projects (Dsc)
# of Projects (Asc)
1.
HIRAOKA Masayasu
(80014281)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
2.
HIRANO Yuji
(00181181)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
3.
TOYAMA Junji
(20023658)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
4.
INOUE Toshimichi
(30028401)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
安井 昭二
(20023781)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
春見 建一
(00102335)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
鈴木 良次
(80013811)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
8.
中山 仁
(70088863)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
國安 明彦
(90241348)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
甲斐 広文
(30194658)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
HORIKAWA Saburo
(10127136)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
TOMOIKE Hitonobu
(90112333)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
MASHIMA Saburo
(30010333)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
KIYOSUE Tatsuto
(90128348)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
SAKAI Fmio
(80302868)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
入沢 宏
(30033947)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
廣田 秋彦
(50156717)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
佐藤 容子
(70251501)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
施 玉りゃん
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
徐 科
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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