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SAWANOBORI Tohru
沢登 徹
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Alternative Names
沢登 徹 サワノボリ トオル
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Researcher Number
00014217
Affiliation (based on the past Project Information)
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1997 – 2000 : 東京医科歯科大学, 難治疾患研究所, 教授
1989 – 1997 : 東京医科歯科大学, 難治疾患研究所, 助教授
1990 : 東京医科歯科大学難治疾患研究所, 助教授
1987 : 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine
/
Anesthesiology/Resuscitation studies
/
General physiology
Keywords
Principal Investigator
reentrant tachycardia / microelectrode method / rabbit right atrium / reentrat tachycardia / streptozotocin / アコニチン細動 / 一過性外向き電流 / 活動電位持続時間 / whole cell patch clamp / effective refractroy period
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/ antiarrhythmic agent / Diabetic rat / 内向きhump電流 / I_K電流遮断薬 / 早期後脱分極 / isolated ventricular myocyte / Na活性型K電流 / proarrhythmia / hypoglycemic sulphonylurea / echo zone / proaarrhythmia / 致死性不整脈 / ATP sensitive K chennel / aggravation of existing arrhythmias / microelectrode / antiarrhythmic drug / ストレプトゾトシン / Mg^<2+>イオン / Zuckerラット / Lucifenn-Luciferase method / bipolar electrode / Antiarrhythmic agent / アチドーシス / 逆頻度依存性 / 遅延整流K電流 / 撃発活動 / reentrrat tachycardia
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Except Principal Investigator
致死性不整脈 / パッチ・クランプ法 / 活動電位再分極相 / 心室筋Na電流モデル / 3次元心臓興奮モデル / スルホニルウレア受容体 / propofol / グリベンクラミド / 光アフィニティラベル / sinus node / ATP感受性Kチャネル / 心室筋再分極モデル / ADP / S100 / 心臓遅延電位 / 麻酔薬 / 一過性外向き電流 / アクチン細骨格 / CD36 / 膜電流 / Patch-clamp technique / ト-センダニン / K-ATPチャネル / 洞結節ペ-スメ-カ電流 / 細胞間結合 / 使用依存性ブロック / ロテイン・カイネース / スカベンジャー受容体 / 抗不整脈薬 / State-dependent affinity / 不活性化状態親和性 / イオン化型と非イオン化型薬剤 / ATP感受性K^+チャネル / 心筋保護 / 不均一な興奮性 / Na^+ channel / イオン化型と非イオン化型薬物 / class I antiarrhythmic drugs / 光学的測定 / 洞結節ペースメーカ電流 / I群抗不整脈薬 / ATPの加水分解 / 心電図シミュレ-ション / Co^<2+> / 致死的不整脈 / Whole-cell current recordings / シタンジン / 虚血とKイオン / inhomogeneous excitability / ischemia and K^+ accumulation / 単一心筋細胞 / 興奮のリエントリ- / アクチン細胞骨格 / protein kinase C / patch-clamp technique / Ca^<2+>放出 / re-entry of excitation / コンピュ-タ・シミュレ-ション / プロティン・カイネース / ATPk感受性Kチャネル / Ca^<2+>-influx / Ca^<2+>電流 / 遅延外向きK^+電流 / 興奮伝導異方向性 / イオン電流解析 / Na^+チャネル抑制の動態 / intracellular ATP / ホモロジー / 細胞内活性化因子 / リエントリ- / チャネル状態親和性 / 電気生理学 / 細胞内増加Ca^<2+> / rundown of the channel activity / 単離心室筋細胞 / 右心房 / マクロファージ / 活性化状態親和性 / modulation of ventricular repolarization / チャネル活性の失活(rundown) / 心室細動シミュレーション / 心室再分極過程の修飾 / 心電図微小電位 / 遅延整流K^+電流 / Ca^<2+>流入 / 膜電位感受性色素 / Kチャネルブロッカー / Increased internal Ca^<2+> / チャネル抑制の速度 / 心室細動 / adenosine / Na^+チャネル / actin cytoskeleton / Single heart cells / 心筋興奮 / ブロック動態と様式 / 不整脈のシミュレ-ション / 電気ショック / Ca^<2+>チャネル / 遅延整流外向き電流 / 心室細動シミュレ-ション / 心室筋活動電位 / 旋回性興奮 / 単一心室筋細胞 / 心筋 / 再活性化 / パッチ・クラプ法 / 心筋再分極 / 細胞内ATP / 心筋Na^+チャネル / ventricular myocytes / 全細胞電流記録 / 心筋脱分極 / Blocking kinetics and modes / プレコンディショニング / チャネルのrundown / Delayed outward K^+ current / アデノシン / ATP-sensitive K^+ channel / Transient outward current / 荷電型と非荷電型薬物 / 三次元解析
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Research Projects
(
18
results)
Co-Researchers
(
20
People)
Project Start Year(Newest)
Project Start Year(Oldest)
Mechanisms of Anesthetics-induced preconditioning in Isolated Heart
Principal Investigator
SAKAI Fmio
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Anesthesiology/Resuscitation studies
Research Institution
Tokyo medical and dental university
新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関
Principal Investigator
中山 仁
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Kumamoto University
Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugs
Principal Investigator
Principal Investigator
SAWANOBORI Tohru
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Medical Research Institute, Tokyo Medical and Dental University
新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析
Principal Investigator
中山 仁
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Kumamoto University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
波長スペクトルの異なる膜電位感受性色素の二重染色による興奮旋回の光学的三次元解析
Principal Investigator
廣田 秋彦
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
General physiology
Research Institution
Tokyo Medical and Dental University
異常状況下でのI_K電流ブロッカーの頻度依存性効果
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
致死性不整脈の成立機序
Principal Investigator
TOYAMA Junji
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Circulatory organs internal medicine
Research Institution
Nagoya University
Mgイオンによる致死性不整脈防止機序に関する研究
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレーション
Principal Investigator
外山 淳治
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究
Principal Investigator
平岡 昌和
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Tokyo Medical and Dental University
心筋興奮の発生と伝導のシミュレ-ション
Principal Investigator
外山 淳治
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical & Dental University, Medical Research Institute
心筋興奮の発生と伝導のシミュレ-ション
Principal Investigator
TOYAMA Junji
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagoya University
糖尿病ラットにおける心筋K^+電流のATP感受性とその変化
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1989
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1989
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis
Principal Investigator
HIRAOKA Masayasu
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
Medical Research Institution, Tokyo Medical and Dental University
糖尿病における心筋変性の成因に関する研究
Principal Investigator
Principal Investigator
沢登 徹
Project Period (FY)
1987
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
Tokyo Medical and Dental University
# of Projects (Dsc)
# of Projects (Asc)
1.
HIRAOKA Masayasu
(80014281)
# of Collaborated Projects :
6results
# of Collaborated Products :
0results
2.
HIRANO Yuji
(00181181)
# of Collaborated Projects :
6results
# of Collaborated Products :
0results
3.
TOYAMA Junji
(20023658)
# of Collaborated Projects :
4results
# of Collaborated Products :
0results
4.
INOUE Toshimichi
(30028401)
# of Collaborated Projects :
4results
# of Collaborated Products :
0results
5.
安井 昭二
(20023781)
# of Collaborated Projects :
3results
# of Collaborated Products :
0results
6.
春見 建一
(00102335)
# of Collaborated Projects :
3results
# of Collaborated Products :
0results
7.
鈴木 良次
(80013811)
# of Collaborated Projects :
2results
# of Collaborated Products :
0results
8.
中山 仁
(70088863)
# of Collaborated Projects :
2results
# of Collaborated Products :
0results
9.
國安 明彦
(90241348)
# of Collaborated Projects :
2results
# of Collaborated Products :
0results
10.
甲斐 広文
(30194658)
# of Collaborated Projects :
2results
# of Collaborated Products :
0results
11.
HORIKAWA Saburo
(10127136)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
12.
TOMOIKE Hitonobu
(90112333)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
13.
MASHIMA Saburo
(30010333)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
14.
KIYOSUE Tatsuto
(90128348)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
15.
SAKAI Fmio
(80302868)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
16.
入沢 宏
(30033947)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
17.
廣田 秋彦
(50156717)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
18.
佐藤 容子
(70251501)
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
19.
施 玉りゃん
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
20.
徐 科
# of Collaborated Projects :
1results
# of Collaborated Products :
0results
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