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SAWANOBORI Tohru  沢登 徹

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沢登 徹  サワノボリ トオル

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Researcher Number 00014217
Affiliation (based on the past Project Information) *help 1997 – 2000: 東京医科歯科大学, 難治疾患研究所, 教授
1989 – 1997: 東京医科歯科大学, 難治疾患研究所, 助教授
1990: 東京医科歯科大学難治疾患研究所, 助教授
1987: 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / Anesthesiology/Resuscitation studies / General physiology
Keywords
Principal Investigator
microelectrode method / rabbit right atrium / reentrant tachycardia / aggravation of existing arrhythmias / echo zone / effective refractroy period / proaarrhythmia / antiarrhythmic drug / reentrat tachycardia / reentrrat tachycardia … More / Antiarrhythmic agent / bipolar electrode / microelectrode / proarrhythmia / antiarrhythmic agent / 一過性外向き電流 / ストレプトゾトシン / Zuckerラット / アチドーシス / 活動電位持続時間 / 逆頻度依存性 / 遅延整流K電流 / I_K電流遮断薬 / Na活性型K電流 / 内向きhump電流 / Mg^<2+>イオン / アコニチン細動 / 早期後脱分極 / 撃発活動 / 致死性不整脈 / hypoglycemic sulphonylurea / whole cell patch clamp / isolated ventricular myocyte / Lucifenn-Luciferase method / ATP sensitive K chennel / Diabetic rat / streptozotocin … More
Except Principal Investigator
致死性不整脈 / パッチ・クランプ法 / propofol / sinus node / S100 / ADP / ATP感受性Kチャネル / 光アフィニティラベル / グリベンクラミド / スルホニルウレア受容体 / 心臓遅延電位 / 3次元心臓興奮モデル / 心室筋再分極モデル / 心室筋Na電流モデル / 活動電位再分極相 / 心筋保護 / プレコンディショニング / 電気生理学 / 麻酔薬 / protein kinase C / adenosine / actin cytoskeleton / intracellular ATP / rundown of the channel activity / ATP-sensitive K^+ channel / アクチン細胞骨格 / 再活性化 / ATPの加水分解 / チャネル活性の失活(rundown) / 細胞内活性化因子 / ATPk感受性Kチャネル / プロティン・カイネース / ロテイン・カイネース / アデノシン / アクチン細骨格 / 細胞内ATP / チャネルのrundown / modulation of ventricular repolarization / inhomogeneous excitability / ischemia and K^+ accumulation / re-entry of excitation / 細胞間結合 / 電気ショック / Kチャネルブロッカー / 興奮伝導異方向性 / 心室細動 / 心室再分極過程の修飾 / 不均一な興奮性 / 虚血とKイオン / 興奮のリエントリ- / patch-clamp technique / ventricular myocytes / Blocking kinetics and modes / State-dependent affinity / Na^+ channel / class I antiarrhythmic drugs / パッチ・クラプ法 / 不活性化状態親和性 / 活性化状態親和性 / イオン化型と非イオン化型薬剤 / 抗不整脈薬 / 心筋Na^+チャネル / Na^+チャネル抑制の動態 / 荷電型と非荷電型薬物 / チャネル抑制の速度 / イオン化型と非イオン化型薬物 / 使用依存性ブロック / 単離心室筋細胞 / ブロック動態と様式 / チャネル状態親和性 / Na^+チャネル / I群抗不整脈薬 / Increased internal Ca^<2+> / Ca^<2+>-influx / Delayed outward K^+ current / Transient outward current / Whole-cell current recordings / Patch-clamp technique / Single heart cells / 遅延整流K^+電流 / Ca^<2+>電流 / Co^<2+> / 遅延外向きK^+電流 / Ca^<2+>放出 / 細胞内増加Ca^<2+> / Ca^<2+>流入 / 遅延整流外向き電流 / 一過性外向き電流 / 全細胞電流記録 / 単一心筋細胞 / CD36 / スカベンジャー受容体 / マクロファージ / ホモロジー / K-ATPチャネル / 心筋 / 三次元解析 / リエントリ- / 光学的測定 / 右心房 / 旋回性興奮 / 膜電位感受性色素 / 心室細動シミュレーション / 洞結節ペースメーカ電流 / 心室細動シミュレ-ション / 洞結節ペ-スメ-カ電流 / シタンジン / ト-センダニン / ATP感受性K^+チャネル / Ca^<2+>チャネル / 単一心室筋細胞 / 致死的不整脈 / 心電図微小電位 / 心電図シミュレ-ション / 心筋再分極 / 心筋脱分極 / イオン電流解析 / 心筋興奮 / 不整脈のシミュレ-ション / 膜電流 / コンピュ-タ・シミュレ-ション / 心室筋活動電位 Less
  • Research Projects

    (18 results)
  • Co-Researchers

    (20 People)
  •  Mechanisms of Anesthetics-induced preconditioning in Isolated Heart

    • Principal Investigator
      SAKAI Fmio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Tokyo medical and dental university
  •  新しいスルホニルウレア結合タンパク質の同定およびK-ATPチャネルとの機能協関

    • Principal Investigator
      中山 仁
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Electrophysiological properties of arryhthmic aggravation by various antiarrhythmic drugsPrincipal Investigator

    • Principal Investigator
      SAWANOBORI Tohru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Medical Research Institute, Tokyo Medical and Dental University
  •  新トランスポーター・スルホニルウレア受容体とK-ATPチャネルの構造と機能の解析

    • Principal Investigator
      中山 仁
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  波長スペクトルの異なる膜電位感受性色素の二重染色による興奮旋回の光学的三次元解析

    • Principal Investigator
      廣田 秋彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Tokyo Medical and Dental University
  •  異常状況下でのI_K電流ブロッカーの頻度依存性効果Principal Investigator

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  致死性不整脈の成立機序

    • Principal Investigator
      TOYAMA Junji
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagoya University
  •  Mgイオンによる致死性不整脈防止機序に関する研究Principal Investigator

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  心筋興奮の発生と伝導のシミュレーション

    • Principal Investigator
      外山 淳治
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  心筋イオン・チャンネル機能を修飾する中国産動植物毒の開発に関する研究

    • Principal Investigator
      平岡 昌和
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
  •  心筋興奮の発生と伝導のシミュレ-ション

    • Principal Investigator
      外山 淳治
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical & Dental University, Medical Research Institute
  •  心筋興奮の発生と伝導のシミュレ-ション

    • Principal Investigator
      TOYAMA Junji
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  糖尿病ラットにおける心筋K^+電流のATP感受性とその変化Principal Investigator

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Medical Research Institution, Tokyo Medical and Dental University
  •  糖尿病における心筋変性の成因に関する研究Principal Investigator

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  • 1.  HIRAOKA Masayasu (80014281)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  HIRANO Yuji (00181181)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  TOYAMA Junji (20023658)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  INOUE Toshimichi (30028401)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  安井 昭二 (20023781)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  春見 建一 (00102335)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  鈴木 良次 (80013811)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  中山 仁 (70088863)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  國安 明彦 (90241348)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  甲斐 広文 (30194658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  HORIKAWA Saburo (10127136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TOMOIKE Hitonobu (90112333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MASHIMA Saburo (30010333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KIYOSUE Tatsuto (90128348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SAKAI Fmio (80302868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  入沢 宏 (30033947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  廣田 秋彦 (50156717)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  佐藤 容子 (70251501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  施 玉りゃん
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  徐 科
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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