SUGIMURA Motoi 杉村基

Researcher Number	30273189
External Links
Affiliation (based on the past Project Information) *help	2012 – 2019: 浜松医科大学, 医学部, 教授 2011: 順天堂大学, 医学部, 准教授 2008 – 2009: Juntendo University, 医学部, 准教授 2006 – 2008: Hamamatsu University School of Medicine, 医学部附属病院, Assistant Prof 2007: 浜松医科大学, 医学部付属病院, 准教授 … More 2002 – 2006: associate Professor, 医学部附属病院, 助教授 2004: Hamamatsu University School of Medicine, Associate professor, 医学部附属病院, 助教授 2002: 浜松医科大学, 医学部, 助手 2002: 浜松医科大学, 医学部付属病院, 助教授 2000 – 2001: 浜松医科大学, 医学部・附属病院, 助手 1998: 浜松医科大学, 医学部, 助手 1998: SAME AS ABOVE,RESEARCH FELOOW, 医学部附属病院, 助手 1996 – 1997: 浜松医科大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator MIF / シグナル伝達 / phosphatidylserine / VEGF / macrophage / 胎仔発育遅延モデル / プロテインC / アンチセンスMIFアデノウイルス / マクロファージ / 妊娠高血圧症候群 … More / 胎児発育不全 / trophoblast / sFLT1 / CD44 / 絨毛細胞 / 胎盤形成 / ヘパラン硫酸 / ヘパリン / 遊走浸潤 / 胎盤絨毛細胞 / リモデリング / 妊娠高血圧 / ヘパリンヘパラン硫酸 / PlGF2 / inflammatoy cytokine / cell signaling / migration / Heparan sulphate / preeclamsia / mouse model / pregnancy-induced hypertension / フォスフアチジルセリン / 胎児子宮内発育遅延 / 光誘発胎盤内凝固 / 妊娠中毒症 / 胎盤内血栓 / 妊娠高血圧症 / 妊娠マウス / intrauterine growth restriction model in mice / protein C / antisense MIF adenovirus / phosphatidylserin / IUGR / recombinant adenovirus / 子宮内胎児発育遅延 / 胎盤マクロファージ / 胎盤内凝固 / フォスファチジルセリン / invasion / PAR / trophoblast cells / 炎症性サイトカイン / 絨毛外絨毛細胞 / preeclampsia / PAR-2 / 再生 / ＣＤ４４ / 早産 / プロスタグランジン受容体EP4 / PGE 2受容体EP4 / プロスタグランジン (PG) E2 / 子宮頚管熟化 / PGE2受容体EP4 / プロスタグランジン(PG)E2 / 子宮頸管熟化 / protein kinase C / prothrombinase / マウス子宮内胎児発育遅延 / phosphotidylserine / 子宮内発育遅延 / annexin V … More Except Principal Investigator 胎盤 / 酸素動態 / 近赤外線 / PIVKA-11 / postpartum / PTVKA / protein S / protein C / venous thromboembolism / DVT / PIVKA-PC / HepG2 / HUVEC / 肥満 / APC感受性 / 血栓症 / PIVKA-II / 産褥 / PIVKA / プロテインS / プロテインC / 静脈血栓症 / transabdominal monitaring / uterus / placenta / oxygenation / near-infrared spectroscopy (NIRS) / 筋赤外線 / 胎児情報 / 酸素 / 子宮収縮 / 子宮筋 / ヘモグロビン / EPIDURAL ANESTHESIA / SYMPATHETIC NERVE / ANGIOSPASTIC SYNDROME / MR ANGIOGRAPHY / HYPERCOAGULABILITY / VASOSPASMS / PREECLAMPSIA / カテコールアミン / Shear stress / 血管攣縮 / HELLP症候群 / 子癇 / 重症妊娠中毒症 / ATIII(アンチトロビンIII) / トロンビン / カテコラミン / 左腎静脈 / 腹部交感神経節 / Angiospastic syndrome / 持続硬膜外麻酔 / 交感神経 / 内因性トロンビン / 血液凝固異常 / MR angiography / 妊娠血管攣縮症候群 / 妊娠中毒症 / 破水 / 捕体 / 羊水塞栓 / 血栓 / 子宮 / DIC / 羊水塞栓症 / 酸素濃度 / 母体腹壁 / 胎児 Less

Regulation of migration of trophoblast cell through cell signaling by heparin-heparansulphate.Principal Investigator
- Principal Investigator
  
  Sugimura Motoi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
The injury and repair system in trophoblast cells through potease-activated receptor and signal transduction.Principal Investigator
- Principal Investigator
  
  Sugimura Motoi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Repair of the damaged trophoblast cells through CD44-mediated signalingPrincipal Investigator
- Principal Investigator
  
  SUGIMURA Motoi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
  Juntendo University
Serological study of amniotic fluid embolism(AFE) and of mechanism of the DIC(disseminated intravascular coagulation) caused by AFE.
- Principal Investigator
  
  HORIUCHI Kentarou
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Regulation of cervical ripening of the uterus through prostaglandin E2 receptor 4Principal Investigator
- Principal Investigator
  
  SUGIMURA Motoi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Juntendo University
  Hamamatsu University School of Medicine
Development of non-invasive transabdominal monitoring of fetal oxygen status
- Principal Investigator
  
  KANAYAMA Naohiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Investigation on the mechanism of deep vein thrombosis during postpartum period
- Principal Investigator
  
  NISHIGUCHI Tomizo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
The role of trophoblast cell damage and coagulopathy in the pregnant mice models with preeclamsia-like symptomsPrincipal Investigator
- Principal Investigator
  
  SUGIMURA Motoi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Instrument for measuring intrauterine oxygen metabolism using optical technique.
- Principal Investigator
  
  KANAYAMA Naohiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
Functional analysis of macrophage in placental coagulation and intrauterine growth restrictionPrincipal Investigator
- Principal Investigator
  
  SUGIMURA Motoi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University, School of Medicine
血小板活性化初期段階の制御とそのin vivo測定法に関する研究Principal Investigator
- Principal Investigator
  
  杉村基
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Hamamatsu University School of Medicine
STUDY ON THE PATHOPHYSIOLOGY OF PREECLAMPSIA : THE MECHANISM OF VASOSPASMS
- Principal Investigator
  
  KOBAYASHI Takao
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  HAMAMATSU UNIVERSITY SCHOOL OF MEDECINE

All 2020 2019 2018 2016 2013 2012 2009 2007 2005 2004 2002

All Journal Article Presentation Book

[Book] 妊娠と生理と栄養　（内分泌学的変化に伴う凝固機能の変化)2020
- Author(s)
  杉村基
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-17K11226
[Book] 播種性血管内凝固症候群(DIC)、わかりやすい周産期・新生児の輸血治療2009
- Author(s)
  田中晶、杉村基、金山尚裕
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-20591911
[Book] 播種性血管内凝固症候群(DIC)、わかりやすい周産期・新生児の輸血治療2009
- Author(s)
  田中晶, 杉村基, 金山尚裕
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-20591911
[Journal Article] Chymotrypsin enhances soluble fms-like tyrosine kinase 1 production through protease-activated receptor 2 in placenta-derived immortalized human trophoblast cells2016
- Author(s)
  Chihiro. Hirai , Motoi. Sugimura , Shintaro. Makino and Satoru. Takeda
- Journal Title
  
  Reproductive Sciences
  
  Volume: 23 Issue: 11 Pages: 1542-1550
- DOI
  10.1177/1933719116646203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462483
[Journal Article] Effectiveness of heparin during long-term tocolysis.2013
- Author(s)
  Inagaki T, MakinoS, yorifuji T, Sugimura M, Takeda S.
- Journal Title
  
  ISRN Obstet Gynecol.
  
  Volume: 2013 Pages: 1-4
- DOI
  10.1155/2013/650532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592416
[Journal Article] Effectiveness of heparin during long-term tocolysis2013
- Author(s)
  Inagaki T, Makino S, Yorifuji T, Sugimura M, Takeda S
- Journal Title
  
  ISRN Obstet Gynecol
  
  Volume: 27 Pages: 650532-650532
- Data Source
  KAKENHI-PROJECT-23592416
[Journal Article] Heparin/heparan sulfate/CD44-v3 enhances cell migration in term placenta-derived immortalized human trophoblast cells2012
- Author(s)
  Suga N. Sugimura M, Kshiishi T, Yorifuji T, Makino S, Takeda S
- Journal Title
  
  Biol reprod
  
  Volume: 134 Pages: 1-8
- Data Source
  KAKENHI-PROJECT-23592416
[Journal Article] Double vertical compression sutures: A novel conservative approach to managing post-partum haemorrhage due to placenta praevia and atonic bleeding.2012
- Author(s)
  Makino S, tanaka T, Yorifuji T, Koshiishi T, Sugimura M, Takeda S.
- Journal Title
  
  Aust N Z J Obstet Gynaecol.
  
  Volume: 52 Issue: 3 Pages: 290-2
- DOI
  10.1111/j.1479-828x.2012.01422.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592416
[Journal Article] Heparin/heparan sulfate/CD44-v3 enhances cell migration in term placenta-derived immortalized human trophoblast cells.2012
- Author(s)
  Suga N. Sugimura M, Kshiishi T, Yorifuji T, Makino S, Takeda S.
- Journal Title
  
  Biol Reprod.
  
  Volume: 134 Issue: 5 Pages: 1-8
- DOI
  10.1095/biolreprod.111.093690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592416
[Journal Article] Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharideinduced cervical ripening in rabbits.2007
- Author(s)
  Fukuda Y, Sugimura M, Suzuki K, Kanayama N.
- Journal Title
  
  Acta Obstet Gynecol Scand. Vol.86,No.11
  
  Pages: 1297-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591893
[Journal Article] Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits2007
- Author(s)
  Fukuda Y, Sugimura M, Suzuki K, Kanayama N
- Journal Title
  
  Acta Obstet Gynecol Scand 86(11)
  
  Pages: 1297-1302
- Data Source
  KAKENHI-PROJECT-18390445
[Journal Article] Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopoly saccharide-induced cervical rienin in rabbits2007
- Author(s)
  Fukuda Y, Sugimura M, Suzuki K, Kanayama N
- Journal Title
  
  Acta Obstet Gynecol Scand. 86(11)
  
  Pages: 1297-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591893
[Journal Article] Sensitivity to activated protein C in patients with deep vein thrombosis during early puerperium period.2005
- Author(s)
  Ohashi R, Sugimura.M, Kawamura T, Tamura N, Kanayama N
- Journal Title
  
  Acta Obstet Gynecol Scand. 84(8)
  
  Pages: 799-801
- Data Source
  KAKENHI-PROJECT-15591739
[Journal Article] Exogenous vascular endothelial growth factor can induce preeclampsia-like symptoms in pregnant mice.2005
- Author(s)
  Murakami Y, Kobayashi T, Omatsu K, Suzuki M, Ohashi R, Matsuura T, Sugimura M, Kanayama N.
- Journal Title
  
  Semin Thromb Hemost. 31(3)
  
  Pages: 307-313
- Data Source
  KAKENHI-PROJECT-15591739
[Journal Article] Phosphatidylserine/phosphatidylcholine microvesicles can induce preeclampsia-like changes in pregnant mice..2005
- Author(s)
  Omatsu K, Kobayashi T, Murakami Y, Suzuki M, Ohashi R, Sugimura M, Kanayama N.
- Journal Title
  
  Semin Thromb Hemost 31(3)
  
  Pages: 314-320
- Data Source
  KAKENHI-PROJECT-15591739
[Journal Article] Alteration of integrins under hypoxic stress in early placenta and choriocarcinoma cell line BeWo.2004
- Author(s)
  Iwaki T, Matsuura T, Sugimura M, Kobayashi T, Kanayama N.
- Journal Title
  
  Gynecol Obstet Invest 57
  
  Pages: 196-203
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370529
[Journal Article] Deficiency in p57^<Kip2> expression induces preeclampsia-like symptoms in mice.2002
- Author(s)
  Kanayama N, Takahashi K, Matsuura T, Sugimura M, Kobayashi T, Moniwa N, Tomita M, Nakayama K
- Journal Title
  
  Mol Hum Reprod 8
  
  Pages: 1129-1135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370529
[Presentation] 胎盤成長因子(PLGF)による培養絨毛外絨毛細胞の遊走浸潤能の検討2019
- Author(s)
  岩田智子, 杉村基, 鳴本敬一郎, 城向賢
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11226
[Presentation] Metformin存在下での培養絨毛外絨毛細胞の遊走浸潤能の検討2019
- Author(s)
  城向賢, 杉村基, 岩田智子, 鳴本敬一郎
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11226
[Presentation] Metformin存在下での培養絨毛外絨毛細胞の遊走浸潤能の検討 Cell migration in the extravillous trophoblast cell line by metformin through PAK-1 signal transduction2019
- Author(s)
  城向賢、杉村基
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11226
[Presentation] 胎盤成長因子(PLGF)による培養絨毛外絨毛細胞の遊走浸潤能の検討 Effect of placental growth factors on the cell migration and invasion in the extravillous trophoblast cell line2019
- Author(s)
  岩田智子、杉村基
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11226
[Presentation] へパリン/へパラン硫酸/ヒアルロナンによるPAK-1シグナル情報伝達系を介した培養絨毛外絨毛細胞の遊走能調節機構の検討 Regulation of the cell migration in the extravillous trophoblast cell lines by heparin/heparan sulfate/hyaruronan through PAK-1 signal transduction2018
- Author(s)
  杉村基
- Organizer
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-17K11226
[Presentation] Urinary trypsin inhibitor : A new treatment for preterm labor2007
- Author(s)
  Kanayama N, Suzuki K, Hirai K, Sugimura M.
- Organizer
  The XXth Asian and Oceanic Congress of Obstetrics and Gynecology
- Place of Presentation
  Tokyo(Japan)
- Data Source
  KAKENHI-PROJECT-18390445

1. KANAYAMA Naohiro (70204550)

# of Collaborated Projects: 8 results

# of Collaborated Products: 11 results
2. NISHIGUCHI Tomizo (30198452)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. SUMIMOTO Kazuhiro (30126817)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KOBAYASHI Takao (20107808)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 茂庭將彦 (00230053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 鳴本敬一郎 (90647603)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 須床和恵 (40343199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HORIUCHI Kentarou (30089841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUGIHARA Kazuhiro (00265878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TANAK Toshitaka (30407283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. MAKINO Shintaro (70570894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. YORIFUJI Takasi (10597058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. TOKUNAGA Naoki (20283369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TERAO Toshihiko (60022852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 河村隆一 (90397422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 竹内欽哉 (80362193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SUGIMURA Motoi 杉村 基

Research Projects

Research Products

Co-Researchers

Regulation of migration of trophoblast cell through cell signaling by heparin-heparansulphate.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The injury and repair system in trophoblast cells through potease-activated receptor and signal transduction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Repair of the damaged trophoblast cells through CD44-mediated signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Serological study of amniotic fluid embolism(AFE) and of mechanism of the DIC(disseminated intravascular coagulation) caused by AFE.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of cervical ripening of the uterus through prostaglandin E2 receptor 4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of non-invasive transabdominal monitoring of fetal oxygen status

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on the mechanism of deep vein thrombosis during postpartum period

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of trophoblast cell damage and coagulopathy in the pregnant mice models with preeclamsia-like symptomsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Instrument for measuring intrauterine oxygen metabolism using optical technique.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of macrophage in placental coagulation and intrauterine growth restrictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血小板活性化初期段階の制御とそのin vivo測定法に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY ON THE PATHOPHYSIOLOGY OF PREECLAMPSIA : THE MECHANISM OF VASOSPASMS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 妊娠と生理と栄養 （内分泌学的変化に伴う凝固機能の変化)2020

Author(s)

Total Pages

Publisher

SUGIMURA Motoi 杉村基

[Book] 妊娠と生理と栄養　（内分泌学的変化に伴う凝固機能の変化)2020