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Ohyagi Yasumasa  大八木 保政

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OHYAGI Yasumasa  大八木 保政

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Researcher Number 30301336
Other IDs
External Links
Affiliation (Current) 2025: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2015 – 2024: 愛媛大学, 医学系研究科, 教授
2015: 愛媛大学, 医学(系)研究科(研究院), 教授
2014: 九州大学, 医学(系)研究科(研究院), その他
2014: 九州大学, 医学研究院, 教授
2013: 九州大学, 医学研究科, 准教授 … More
2012 – 2013: 九州大学, 医学(系)研究科(研究院), 教授
2012: 九州大学, 医学研究院, 教授
2012: 九州大学, 大学院・医学研究院, 教授
2008 – 2012: 九州大学, 医学研究院, 准教授
2010: 九州大学, 大学院・医学研究院, 准教授
2007: Kyushu University, Department of Neurology, Associate Professor
2006: 九州大学, 大学院医学研究院, 助教授
2004 – 2005: 九州大学, 大学病院, 講師
2002 – 2003: 九州大学, 大学院・医学研究院, 講師
2002: Kyushu University Hospital, Department of Neurology, associate professor, 医学部附属病院, 講師
2001: 九州大学, 医学部・附属病院, 講師
2000: 九州大学, 医学部・附属病院, 助手
1998 – 1999: 九州大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Neurology / Basic Section 52010:General internal medicine-related / Biological Sciences / Neurology / General internal medicine(including psychosomatic medicine)
Except Principal Investigator
Radiation science / Neurology / Basic Section 52020:Neurology-related / Basic Section 57080:Social dentistry-related / Basic Section 52010:General internal medicine-related / Neurology / Cerebral neurosurgery / Risk sciences of radiation/Chemicals
Keywords
Principal Investigator
アルツハイマー病 / アミロイドβ蛋白 / p53 / アポモルフィン / モデルマウス / アポトーシス / 糖尿病 / プロモーター / インスリンシグナリング / リン酸化タウ蛋白 … More / 毒性ターン / 熱ショック / 神経細胞 / 酸化ストレス / 老化 / 薬理学 / 脳神経疾患 / 培養細胞 / apoptosis / Alzheimer's disease / 3xTg-ADマウス / インスリン分解酵素 / インスリン抵抗性 / アミロイドβ / ニューロン / プレセニリン / プロテオーム解析 / p53プロモーター / 核DNA傷害 / 神経細胞防護 / 認知症 / インスリンシグナル / 細胞毒性 / ドパミン受容体 / 糖尿病薬 / 痴呆 / オリゴマー / 毒性ターン構造 / oxidative stress / neurofibrillary tangle / cognitive function / 3x transgenic mouse / apomorphine sulfate / amyloid β-protein / 神経保護 / プロテアソーム / 神経原線維変化 / 認知機能 / 3Xトランスジェニックマウス / 塩酸アポモルフィン / presenilin / proteome analysis / promoter / neuron / Amyloid-β protein / インスリン分泌能 / 記憶機能 / インスリン受容体基質 / 記憶障害 / モリス水迷路 / 小胞体ストレス / 神経分子病態学 / 転写 / 熱ショック蛋白 / 細胞防御 … More
Except Principal Investigator
アルツハイマー病 / MRI / bio-flavonoid / cytotoxicity / tauopathy / 認知症 / microRNA / 毒性ターンアミロイドβ蛋白 / 毒性ターンAβ / マイクロRNA / エキソソーム / バイオマーカー / 神経細胞 / オートファジー / 口腔機能低下 / 老化 / 動脈硬化 / インスリン抵抗性 / 認知機能低下 / フレイル / 終末糖化産物 / サルコペニア / Kindling / Animal model / Neuronal migration disorder / Focal cortical malformation / Epilepsy / Freeze lesion / 神経新生 / てんかん原性 / 皮質形成異常 / 新皮質 / キンドリング / 動物モデル / 神経遊走障害 / 局所皮質形成異常 / てんかん / PC12 neuronal culture cell line / CTG repeat / triplet repeat disease / myotonic dystrophy / flavonoid / PC12 / CTGリピート / トリプレットリピート病 / 筋強直性ジストロフィー / PET / MRI / PET / アミロイド / 単球走化性蛋白1 / 樹状細胞 / 孤発性筋萎縮性側索硬化症 / 運動ニューロン / カルシウム結合蛋白 / 脊髄前側索 / TDP-43 / マクロファージ / ミクログリア / 単球走化性蛋白質1 / カルレチニン / 筋萎縮性側索硬化症 / verify now / 脳動脈コイル塞栓術 / 頸動脈ステント留置術 / 脳血管内治療 / PON-1 / CYP2C19 / 血小板不応症 / Verify now / CYP2C19 / クロピドグレル / 遺伝子多型 / 抗血小板薬不応性 / 頚動脈ステント留置術 / ミオパチー / 拡散 / テンソル / 骨格筋 / Muscle / DTI / DWI / 脳 / 軽度認知障害 / 脳神経疾患 / 脳・神経 / 環境スレス / DNA修復 / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル / 化学物質 / 環境ストレス / 自然突然変異 / 細胞増殖阻害 / ヌクレオチドプール / 酸化的損傷 / 神経変性 / 細胞死 / バイスタンダー効果 / 突然変異 / RNA / DNA / 放射線 / 活性酸素 / 機能的MRI(fMRI) / 視覚誘発電位(VEP) / 事象関連電位(ERP) / アルツハイマー病(AD) / 軽度認知機能障害(MCI) / サブタイプ / マルチモーダル視覚刺激 / 機能的MRI / 視覚誘発電位 / 事象関連電位 / 軽度認知機能障害 Less
  • Research Projects

    (22 results)
  • Research Products

    (150 results)
  • Co-Researchers

    (52 People)
  •  Elucidation of the mechanism by which aging-induced deterioration of oral function is involved in the development of Alzheimer's disease.

    • Principal Investigator
      後藤 哲哉
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57080:Social dentistry-related
    • Research Institution
      Kagoshima University
  •  アルツハイマー病のインスリンシグナリング標的治療:モデルマウスにおける解析Principal Investigator

    • Principal Investigator
      大八木 保政
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Ehime University
  •  毒性ターンAβ42含有エキソソームによるアルツハイマー病早期診断と病態伝搬の解明

    • Principal Investigator
      今村 友裕
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      International University of Health and Welfare
  •  サルコペニア・動脈硬化・認知機能低下の新規治療標的としてのAGEsの探究

    • Principal Investigator
      越智 雅之
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Ehime University
  •  Molecular pathology and therapeutics of insulin signaling impairment and Abeta in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      Ohyagi Yasumasa
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Ehime University
  •  Impairment of insulin signaling in Alzheimer's disease and combined therapy with apomorphine and insulinPrincipal Investigator

    • Principal Investigator
      Ohyagi Yasumasa
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Ehime University
  •  Development of apomorphine therapy targeting insulin resistance in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      Ohyagi Yasumasa
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Ehime University
      Kyushu University
  •  Development of MR molecular imaging for brain amyloid detection: PET/MRI approach

    • Principal Investigator
      YOSHIURA Takashi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Kagoshima University
  •  Novel therapeutic strategy for amyotrophic lateral sclerosis targeting calretinin and monocyte chemoattractant protein-1

    • Principal Investigator
      HAYASHI SHINTARO
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress

    • Principal Investigator
      NAKABEPPU YUSAKU
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Kyushu University
  •  Development of apomorphine therapy for Alzheimer diseasePrincipal Investigator

    • Principal Investigator
      OHYAGI Yasumasa
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  Development of multi-parametric MRI for preclinical diagnosis of Alzheimer's disease

    • Principal Investigator
      YOSHIURA Takashi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Kyushu University
  •  Evaluation of neuromuscular disease activity by diffusion tensor imaging

    • Principal Investigator
      HATAKENAKA Masamitsu
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Sapporo Medical University
      Kyushu University
  •  The influence of genetic polymorphism on preoperative platelet function testing in patients undergoing Carotid Artery Stenting

    • Principal Investigator
      MATSUMOTO Shoji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kyushu University
  •  Early diagnosis and subtype classification of mild cognitive impairment using multimodal visual stimuli

    • Principal Investigator
      YAMASAKI Takao
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  Development of methods to inhibit apoptosis induced by intracellular amyloid β-protein in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      OHYAGI Yasumasa
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  Epileptogenicity of neocortex in the novel rat model of focal cortical dysplasia

    • Principal Investigator
      SHIGETO Hiroshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      KYUSHU UNIVERCITY
  •  Analysis of the effect with the, expanded CTG repeat for cell toxicity, especially tauopathy in the central nervous system in patietnt of myotonic dystrophy type 1 (DM 1)

    • Principal Investigator
      FURUYA Hirokazu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  細胞内アミロイドβ誘導性ニューロン死と家族性アルツハイマー病の分子メカニズムに関する研究Principal Investigator

    • Principal Investigator
      大八木 保政
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  Search for the proteins linked to Alzheimer's disease-specific neuronal death and application for the therapeutics.Principal Investigator

    • Principal Investigator
      OHYAGI Yasumasa
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University
  •  アルツハイマー病の細胞内Aβ42誘導性ニューロンアポトーシス死の分子メカニズムPrincipal Investigator

    • Principal Investigator
      大八木 保政
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyushu University
  •  神経細胞の酸化ストレスとその防御因子に関する研究Principal Investigator

    • Principal Investigator
      大八木 保政
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Kyushu University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] Diabetes Mellitus: A risk factor for Alzheimer's disease? Chapter: Therapeutic strategies for Alzheimer's disease in the view of diabetes mellitus2018

    • Author(s)
      Ohyagi Y, Nakamura N, Miyoshi K
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Book] Diabetes Mellitus: A risk factor for Alzheimer's Disease? Chapter: Therapeutic strategies for Alzheimer's disease in the view of diabetes mellitus2017

    • Author(s)
      Ohyagi Y
    • Publisher
      Springer Nature
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Book] 最新医学別冊 新しい診断と治療のABC 22.アルツハイマー病 改訂第2版2014

    • Author(s)
      大八木保政
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] Bioimpedance phase angle is independently associated with myosteatosis: The Shizuoka study2023

    • Author(s)
      Michitaka Kato, Yoko Okada, Wataru Nakano, Daisuke Takagi, Masayuki Ochi, Yasumasa Ohyagi, Michiya Igase, Yasuharu Tabara, The Shizuoka, study group
    • Journal Title

      Clinical Nutrition

      Volume: 42 Issue: 5 Pages: 793-799

    • DOI

      10.1016/j.clnu.2023.03.016

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K19466, KAKENHI-PROJECT-21K17501, KAKENHI-PROJECT-19K11312, KAKENHI-PROJECT-21K07390, KAKENHI-PROJECT-21H04850
  • [Journal Article] Case report: Frontotemporal dementia and amyotrophic lateral sclerosis caused by a missense variant (p.Arg89Trp) in the valosin-containing protein gene2023

    • Author(s)
      Miura Shiroh、Hiruki Shigeyoshi、Okada Tomohisa、Takei Satoko Itani、Senzaki Kensuke、Okada Yoko、Ochi Masayuki、Tanabe Yuki、Ochi Hirofumi、Igase Michiya、Ohyagi Yasumasa、Shibata Hiroki
    • Journal Title

      Frontiers in Genetics

      Volume: 14 Pages: 1155998-1155998

    • DOI

      10.3389/fgene.2023.1155998

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Journal Article] Reduced Autophagy in Aged Trigeminal Neurons Causes Amyloid β Diffusion2023

    • Author(s)
      Sonoda R、Kuramoto E、Minami S、Matsumoto SE、Ohyagi Y、Saito T、Saido T、Noguchi K、Goto T.
    • Journal Title

      Journal of Dental Research

      Volume: - Issue: 8 Pages: 938-946

    • DOI

      10.1177/00220345231156095

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07826, KAKENHI-PROJECT-20K10296, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-22K10039, KAKENHI-PROJECT-23K06886
  • [Journal Article] Alzheimer病の糖尿病的機序と高齢者の認知症予防.2023

    • Author(s)
      大八木保政
    • Journal Title

      神経治療学

      Volume: 40 Pages: 208-213

    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Journal Article] Associations between adiponectin and leptin levels and skeletal muscle mass and myosteatosis in older adults: The Shimanami Health Promoting Program study2023

    • Author(s)
      Tabara Yasuharu、Okada Yoko、Ochi Masayuki、Ohyagi Yasumasa、Igase Michiya
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 23 Issue: 6 Pages: 444-449

    • DOI

      10.1111/ggi.14582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07390, KAKENHI-PROJECT-21H04850
  • [Journal Article] 【特集】認知症予防を考慮した糖尿病の治療.未来の治療薬開発.2023

    • Author(s)
      大八木保政
    • Journal Title

      月刊糖尿病#150

      Volume: 15 Pages: 70-76

    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Journal Article] Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model.2022

    • Author(s)
      Kuramoto E, Kitawaki A, Yagi T, Kono H, Matsumoto SE, Hara H, Ohyagi Y, Iwai H, Yamanaka A, Goto T.
    • Journal Title

      Front Aging Neurosci.

      Volume: 14 Pages: 935033-935033

    • DOI

      10.3389/fnagi.2022.935033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09916, KAKENHI-PROJECT-22K19636, KAKENHI-PROJECT-19K10047, KAKENHI-PROJECT-19K10058, KAKENHI-PROJECT-20K07826, KAKENHI-PROJECT-20K10296
  • [Journal Article] "認知症+併存疾患"アプローチの最前線.各併存疾患の対策と管理:生活習慣病.2022

    • Author(s)
      大八木保政
    • Journal Title

      内科

      Volume: 129 Pages: 1303-1305

    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Journal Article] 認知症の臨床update.2022

    • Author(s)
      大八木保政
    • Journal Title

      日本内科学会雑誌

      Volume: 111 Pages: 436-440

    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Journal Article] Dermal advanced glycation end-product accumulation is associated with sarcopenia-related measures in middle-aged and older men.2022

    • Author(s)
      Matsumoto S, Ochi M, Akechi Y, Takei S, Senzaki K, Okada Y, Miura S, Ochi H, Igase M, Ohyagi Y.
    • Journal Title

      Arch Gerontol Geriatr.

      Volume: 101 Pages: 104704-104704

    • DOI

      10.1016/j.archger.2022.104704

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07390, KAKENHI-PROJECT-20K07826
  • [Journal Article] 認知症の臨床update2022

    • Author(s)
      大八木保政
    • Journal Title

      日本内科学会雑誌

      Volume: 111 Pages: 436-440

    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Journal Article] アルツハイマー病2021

    • Author(s)
      大八木保政
    • Journal Title

      今日の治療指針

      Volume: 63 Pages: 979-981

    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Journal Article] Insulin deficiency promotes formation of toxic amyloid-beta42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.2020

    • Author(s)
      Imamura T, Yanagihara YT, Ohyagi Y, Nakamura N, Iinuma KM, Yamasaki R, Asai H, Maeda M, Murakami K, Ilie K, Kira JI
    • Journal Title

      Neurobiology of Disease

      Volume: 137 Pages: 104739-104739

    • DOI

      10.1016/j.nbd.2020.104739

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09302, KAKENHI-PROJECT-17K09757, KAKENHI-PROJECT-20K07826
  • [Journal Article] 糖尿病+アルツハイマー病モデルマウスの分子病態と治療戦略2020

    • Author(s)
      大八木保政,今村友裕,武井聡子
    • Journal Title

      Dementia Japan

      Volume: 34 Pages: 253-262

    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Journal Article] Insulin signaling as a therapeutic target in Alzheimer's disease: Efficacy of apomorphine.2020

    • Author(s)
      Ohyagi Y, Takei SI
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 8 Issue: 3 Pages: 12369-12369

    • DOI

      10.1111/ncn3.12369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09302, KAKENHI-PROJECT-20K07826
  • [Journal Article] Neurodegeneration of trigeminal mesencephalic neurons by the tooth loss triggers the progression of Alzheimer's disease in 3xTg-AD model mice.2020

    • Author(s)
      Goto T, Kuramoto E, Dhar A, Wang RP-H, Seki H, Iwai H, Yamanaka A, Matsumoto S, Hara H, Michikawa M, Ohyagi Y, Leung WK, Chang RC-C
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 76 Issue: 4 Pages: 1443-1459

    • DOI

      10.3233/jad-200257

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07826, KAKENHI-PROJECT-20K07861, KAKENHI-PROJECT-20K10296, KAKENHI-PLANNED-17H06311
  • [Journal Article] Therapeutic Strategies for Alzheimer's Disease in the View of Diabetes Mellitus2019

    • Author(s)
      Ohyagi y, Miyoshi K, Nakamura N
    • Journal Title

      Adv Exp Med Biol

      Volume: 1128 Pages: 227-248

    • DOI

      10.1007/978-981-13-3540-2_11

    • ISBN
      9789811335396, 9789811335402
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Journal Article] 認知症の診断:アルツハイマー病2018

    • Author(s)
      大八木保政
    • Journal Title

      臨床と研究

      Volume: 95 Pages: 233-237

    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Journal Article] Apomorphine therapy for neuronal insulin resistance in a mouse model of Alzheimer's disease2017

    • Author(s)
      Nakamura N, Ohyagi Y, Imamura T, Yanagihara YT, Iinuma KM, Soejima N, Murai H, Yamasaki R, Kira J
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] Apomorphine therapy for neuronal insulin resistance in a mouse model of Alzheimer's disease2017

    • Author(s)
      Nakamura N, Ohyagi Y, Imamura T, Yanagihara YT, Iinuma KM, Soejima N, Murai H, Yamasaki R, Kira J
    • Journal Title

      Journal of Alzheimer's Disease

      Volume: 58 Issue: 4 Pages: 1151-1161

    • DOI

      10.3233/jad-160344

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Journal Article] アルツハイマー型認知症の予防2017

    • Author(s)
      大八木保政
    • Journal Title

      Bio Clinica

      Volume: 32 Pages: 39-43

    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Journal Article] アルツハイマー型認知症の予防2017

    • Author(s)
      大八木保政
    • Journal Title

      Bio Clinica

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] アルツハイマー病:脳の糖尿病の治療薬開発2017

    • Author(s)
      大八木保政
    • Journal Title

      老年期認知症研究会誌

      Volume: 21

    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] アルツハイマー病のインスリン抵抗性とアポモルフィン治療の開発2016

    • Author(s)
      大八木保政
    • Journal Title

      Dementia Japan

      Volume: 未定

    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles2014

    • Author(s)
      Fujii T, Hayashi S, Kawamura N, Higuchi MA, Tsugawa J, Ohyagi Y, Hayashi YK, Nishino I, Kira J
    • Journal Title

      J Neurol Sci

      Volume: 343 Pages: 206-210

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461317
  • [Journal Article] 【認知症の原因・予防から診断・治療まで】代表的な認知症の診療:アルツハイマー病2014

    • Author(s)
      大八木保政
    • Journal Title

      臨牀と研究

      Volume: 91 Pages: 892-896

    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] 次世代のAlzheimer病に対する医薬開発:細胞内Aβの分子病態とアポモルフィン治療2014

    • Author(s)
      大八木保政,中村憲道
    • Journal Title

      神経内科

      Volume: 80 Pages: 376-382

    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] Early inhibition of TNF-α and IL-6 in muscle tissues as a therapy for dystrophinopathy in mdx mice2014

    • Author(s)
      Arahata H, Ohyagi Y, Iinuma KM, Tanaka M, Tateishi T, Yamasaki R, Matsushita T, Kira J
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 5 Issue: 3 Pages: 371-377

    • DOI

      10.1111/cen3.12111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles2014

    • Author(s)
      Fujii T, Hayashi S, Kawamura N, Higuchi M, Tsugawa J, Ohyagi Y, Hayashi YK, Nishino I, Kira J
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 343 Issue: 1-2 Pages: 206-210

    • DOI

      10.1016/j.jns.2014.05.056

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochpondrial DNA mutation for Leber’s hereditary optic neuropathy2014

    • Author(s)
      Shiraishi W, Hayashi S, Kamada T, Isobe N, Yamasaki R, Murai H, Ohyagi Y, Kira J
    • Journal Title

      Multiple Sclerosis

      Volume: 20 Issue: 2 Pages: 258-260

    • DOI

      10.1177/1352458513513057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Journal Article] 次世代アルツハイマー医薬開発:細胞内Aβの分子病態とアポモルフィン治療2013

    • Author(s)
      大八木保政
    • Journal Title

      神経治療学

      Volume: (印刷中)

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.2013

    • Author(s)
      Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J
    • Journal Title

      CurrAlzheimer Res

      Volume: 10 Issue: 1 Pages: 11-20

    • DOI

      10.2174/1567205011310010003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
  • [Journal Article] Aluminium and Alzheimer's disease: An update2013

    • Author(s)
      Ohyagi Y, Miyoshi K
    • Journal Title

      J Alzheimer's Dis & Parkinsonism

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Impaired cytoplastic-nuclear transport of hypoxia-inducible factor-1αin amgotrophic lateral sclerosis.2013

    • Author(s)
      Kira J et al
    • Journal Title

      Brain Pathol

      Volume: - Issue: 5 Pages: 534-546

    • DOI

      10.1111/bpa.12040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659459, KAKENHI-PROJECT-23790997, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-25461317
  • [Journal Article] Alzheimer's disease: diagnosis by different methods of voxel-based morphometry2012

    • Author(s)
      Dashjamts T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Ohyagi Y, Monji A, Kamano H, Kawashima T, Kira J, Honda H
    • Journal Title

      Fukuoka Igaku Zasshi

      Volume: 103(3) Pages: 59-69

    • NAID

      40019326251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591340
  • [Journal Article] Therapeutics targeting intracellular amyloid β-protein in Alzheimer's disease: A novel effect of apomorphine2012

    • Author(s)
      Ohyagi Y
    • Journal Title

      Advances in Alzheimer Research

      Volume: 1 Pages: 272-290

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] 細胞内アミロイドβおよび酸化ストレスを標的とする治療薬2012

    • Author(s)
      大八木保政
    • Journal Title

      神経内科

      Volume: 77 Pages: 158-164

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Chapter12: Therapeutics targeting intracellular amyloid β-protein in Alzheimer’s disease: A novel effect of apomorphine2012

    • Author(s)
      Yasumasa Ohyagi
    • Journal Title

      Advances in Alzheimer Research

      Volume: 1 Pages: 272-290

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Apomorphine: A novel efficacy for Alzheimer's disease and its mechanism.2012

    • Author(s)
      Ohyagi Y
    • Journal Title

      J Alzheimers Dis & Parkinsonism

      Volume: 2 Issue: 04

    • DOI

      10.4172/2161-0460.1000e122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] 細胞内アミロイドβおよび酸化ストレスを標的とする治療薬:アポモルフィン2011

    • Author(s)
      大八木保政
    • Journal Title

      臨床神経

      Volume: 51 Pages: 884-887

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine.2011

    • Author(s)
      Ma L, Ohyagi Y, Nakamura N, Iinuma KM, Miyoshi K, Himeno E, Soejima N, Yanagihara YT, Sakae N, Yamasaki R, Kira J
    • Journal Title

      J Alzheimers Dis

      Volume: 27 Issue: 1 Pages: 225-237

    • DOI

      10.3233/jad-2011-110140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
  • [Journal Article] Simultaneous arterial spin labeling cerebral blood flow and morphological assessments for detection of Alzheimer's disease2011

    • Author(s)
      Dashjamts T, Yoshiura T, Hiwatashi A, Yamashita K, Monji A, Ohyagi Y, Kamano H, Kawashima T, Kira JI, Honda H
    • Journal Title

      Acad Radiol

      Volume: 18(12) Pages: 1492-1499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591340
  • [Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation2011

    • Author(s)
      Himeno E, Ohyagi Y, et al.
    • Journal Title

      Annals of Neurology

      Volume: 69 Pages: 248-256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] 細胞内アミロイドβおよび酸化ストレスを標的とする治療薬:アポモルフィン2011

    • Author(s)
      大八木保政
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 884-887

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.2011

    • Author(s)
      Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J
    • Journal Title

      Ann Neurol

      Volume: 69 Issue: 2 Pages: 248-256

    • DOI

      10.1002/ana.22319

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590936, KAKENHI-PROJECT-23890150
  • [Journal Article] Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomicalregistration through exponentiated lie algebra analysis2011

    • Author(s)
      Yoshiura T, Hiwatashi A, Yamashita K, Ohyagi Y, Monji A, Takayama Y, Kamano H, Kawashima T, Kira JI, Honda H
    • Journal Title

      Eur Radiol

      Volume: 21(2) Pages: 419-425

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591340
  • [Journal Article] 認知症の症状・診断基準と重症度評価:アルツハイマー型認知症2011

    • Author(s)
      大八木保政
    • Journal Title

      臨床と研究

      Volume: 88 Pages: 553-656

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] 先端認知症研究・医療施設の現在:九州大学医学研究院附属脳神経病研究施設2010

    • Author(s)
      大八木保政, ほか
    • Journal Title

      Cognition and Dementia

      Volume: 9 Pages: 74-77

    • Data Source
      KAKENHI-PROJECT-22590936
  • [Journal Article] 九州大学病院における神経内科・精神科共同のもの忘れ外来2008

    • Author(s)
      三好克枝, 大八木保政, 山崎貴男, 他
    • Journal Title

      6年間の診療の検討.神経治療学 25(5)

      Pages: 597-603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591026
  • [Journal Article] アルツハイマー病の新しい治療法の開発新規医薬品Aβ分解促進薬塩酸アポモルフィン2008

    • Author(s)
      大八木 保政, ら
    • Journal Title

      日本臨床増刊号 66

      Pages: 498-501

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Intraneuronal amyloid β42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi, Y, Tsuruta, Y, Motomura, K, et. al.
    • Journal Title

      Journal of Neuroscience Methods 159

      Pages: 134-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] 細胞内Aβ分解促進による神経細胞死2007

    • Author(s)
      大八木 保政, ら
    • Journal Title

      日本神経精神薬理学雑誌 27

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Intraneuronal amyloid β42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi Y, et. al.
    • Journal Title

      Journal of Neuroscience Methods 159

      Pages: 134-138

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Intraneuronal amyloid β42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi Y, Tsuruta Y, Motomura K, Miyoshi K, Kikuchi H, Iwaki T, Taniwaki T, Kira J
    • Journal Title

      Journal of Neuroscience Methods 159

      Pages: 134-138

    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Intraneuronai amyloid β42 enhanced by heating but counteracted by formic acid2007

    • Author(s)
      Ohyagi Y, et. al.
    • Journal Title

      Journal of Neuroscience Methods 159

      Pages: 134-138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Functional network of the basal ganglia and cerebellar motor loops in vivo : different activation patterns between self-initiated and externally triggered movements.2006

    • Author(s)
      Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S.
    • Journal Title

      Neuroimage 31

      Pages: 745-53

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Motor neuron disorder simulating ALS induced by chronic inhalation of pyrethroid insecticides.2006

    • Author(s)
      Doi H, Kikuchi H, Murai H, Kawano Y, Shigeto H, Ohyagi Y, Kira J.
    • Journal Title

      Neurology 67

      Pages: 1894-1985

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Functional network of the basal ganglia and cerebellar motor loops in vivo : Different activation patterns between self-initiated and externally triggered movements.2006

    • Author(s)
      Taniwaki T, Okayama A, Yoshiura T, Togao O, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira JI, Tobimatsu S.
    • Journal Title

      Neuroimage Feb(E pub ahead)

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene.2006

    • Author(s)
      Furuya H, Murai H, Takasugi K, Ohyagi Y, Urano F, Kishi T, Ichinose H, Kira J.
    • Journal Title

      Clin Neurol Neurosurg. 108

      Pages: 784-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] アミロイドβ蛋白と細胞毒性2006

    • Author(s)
      大八木保政
    • Journal Title

      Pharma Medica 24・7

      Pages: 25-29

    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Intracellular amyloid β-protein and its associated molecules in the pathogenesis of Alzheimer's disease.2006

    • Author(s)
      Ohyagi Y, Tabira T
    • Journal Title

      Mini-Reviews in Medicinal Chemistry 6

      Pages: 1075-1080

    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] アルツハイマー病の分子病態と治療-特にアミロイドβ蛋白を標的として-2006

    • Author(s)
      大八木保政
    • Journal Title

      福岡医学雑誌 97・9

      Pages: 261-268

    • NAID

      120002564571

    • Data Source
      KAKENHI-PROJECT-18590948
  • [Journal Article] Functional network of the basal ganglia and cerebellar motor loops in vivo : different activation patterns between self-initiated and externally triggered movements.2006

    • Author(s)
      Taniwaki T, Okayama A, Yoshiura T, Togao 0, Nakamura Y, Yamasaki T, Ogata K, Shigeto H, Ohyagi Y, Kira J, Tobimatsu S.
    • Journal Title

      Neuroimage. 31

      Pages: 745-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of adult-onset Sydenham chorea accompanied with psychiatric symptoms2006

    • Author(s)
      Kin S, Taniwaki T, Shigeto H, Nomura T, Ohyagi Y.
    • Journal Title

      No To Shinkei 58

      Pages: 155-159

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene.2006

    • Author(s)
      Furuya H, Murai H, Takasugi K, Ohyagi Y, Urano F, Kishi T, Ichinose H, Kira J.
    • Journal Title

      Clin Neurol Neurosurg 108

      Pages: 784-6

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Intracellular A beta 42 activates p53 promoter : a pathway to neurodegeneration in Alzheimer's disewase2005

    • Author(s)
      Ohyagi Y, Asahara H, Kira J, Tabira T
    • Journal Title

      FASEB J 19

      Pages: 255-257

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene.2005

    • Author(s)
      Furuya H, Murai H, Takasugi K, Ohyagi Y, Urano F, Kishi T, Ichinose H, Kira J
    • Journal Title

      Clin Neurol Neurosurg Nov(E pub ahead)

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.2005

    • Author(s)
      Furuya H, Shinnoh N, Ohyagi Y, Ikezoe K, Kikuchi H, Osoegawa M, Fukumaki Y, Nakabeppu Y, Hayashi T, Kira J.
    • Journal Title

      Biochem Pharmacol 69

      Pages: 503-16

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.2005

    • Author(s)
      Furuya H, Shinnoh N, Ohyagi Y, Ikezoe K, Kikuchi H, Osoegawa M, Fukumaki Y, Nakabeppu Y, Hayashi T, Kira J.
    • Journal Title

      Biochem Pharmacol 69(3)

      Pages: 503-516

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A patient with paraneoplastic limbic encephalitis induced by breast cancer presenting with hypersomnia2005

    • Author(s)
      Kawamura N, Kawajiri M, Ohyagi Y, Minohara M, Murai H, Kira J.
    • Journal Title

      Rinsho Shinkeigaku 45(8)

      Pages: 575-578

    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant.2005

    • Author(s)
      Furuya H, Shinnoh N, Ohyagi Y, Ikezoe K, Kikuchi H, Osoegawa M, Fukumaki Y, Nakabeppu Y, Hayashi T, Kira J.
    • Journal Title

      Biochem Pharmacol. 69

      Pages: 503-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of dermato-fasciitis : amyopathic dermatomyositis associated with fasciitis.2004

    • Author(s)
      Tsuruta Y, Ikezoe K, Nakagaki H, Shigeto H, Kawajiri M, Ohyagi Y, Kira J.
    • Journal Title

      Clin Rheumatol. 23

      Pages: 160-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A case of dermato-fasciitis : amyopathic dermatomyositis associated with fasciitis.2004

    • Author(s)
      Tsuruta Y, Ikezoe K, Nakagaki H, Shigeto H, Kawajiri M, Ohyagi Y, Kira J.
    • Journal Title

      Clin Rheumatol 23

      Pages: 160-162

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590832
  • [Journal Article] A deficit of dorsal stream function in patients with amnestic mild cognitive impairment.

    • Author(s)
      Yamasaki T, Horie S, Himeno E, Namamura N, Ohyagi Y, Kira JI, Tobimatsu S.
    • Journal Title

      Clin Neurophysiol

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591026
  • [Patent] アルツハイマー病の予防・治療剤2007

    • Inventor(s)
      大八木 保政
    • Industrial Property Rights Holder
      九州大学
    • Filing Date
      2007-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Presentation] 高齢者における潜在的記憶機能低下のリスク評価2023

    • Author(s)
      武井聡子、越智雅之、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] 地域在住健常高齢者における記憶機能低下とリスクスコアリングの相関2023

    • Author(s)
      越智雅之、武井聡子、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第65回日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] Apomorphine activates insulin signaling and protects cells from Alzheimer’s amyloid-beta toxicity.2023

    • Author(s)
      藤下幸穂、武井聡子、三浦史郎、越智雅之、大八木保政
    • Organizer
      第64回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Presentation] 教育講演1:高齢者の脳卒中2023

    • Author(s)
      大八木保政
    • Organizer
      第65回日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Presentation] V180I変異プリオン病患者3例の解析:アミロイドβオリゴマーの病態関与の可能性.2023

    • Author(s)
      大八木保政、桑垣詩織、千崎健佑、松本清香、越智雅之
    • Organizer
      第42回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06886
  • [Presentation] 高齢者の記銘力低下のスクリーニングとしての皮下AGEs蓄積測定の可能性2023

    • Author(s)
      武井聡子、越智雅之、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第42回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] シンポジウム6 代謝性疾患と認知症update 2022:脳のインスリンシグナリングを標的とするアルツハイマー病の治療戦略2022

    • Author(s)
      大八木保政
    • Organizer
      第22回日本抗加齢医学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 簡易フレイルスコアは高齢者の認知機能低下と関連する2022

    • Author(s)
      越智雅之、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第63回日本神経学会総会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] 地域在住健常高齢者における簡易フレイルスコアと認知機能の関連2022

    • Author(s)
      越智雅之、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第64回日本老年医学会総会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] 特別講演:高齢者のフレイルと早期認知症 ー終末糖化産物(AGEs)と予防サプリメントの開発ー2022

    • Author(s)
      大八木保政
    • Organizer
      第22回日本早期認知症学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 教育講演5:アルツハイマー病の糖尿病的機序と高齢者の認知症予防2022

    • Author(s)
      大八木保政
    • Organizer
      第40回日本神経治療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 認知症と糖尿病:共通の病態機序と認知症の治療標的の可能性2022

    • Author(s)
      大八木保政
    • Organizer
      第56回糖尿病学の進歩
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 超高齢社会における内科学.認知症の臨床update2021

    • Author(s)
      大八木保政
    • Organizer
      第49回内科学の展望
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 認知症の臨床update2021

    • Author(s)
      大八木保政
    • Organizer
      第62回日本神経学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 皮膚の終末糖化産物(AGEs)蓄積は簡易フレイルスコアと相関する2021

    • Author(s)
      武井聖空、越智雅之、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第63回日本老年医学会総会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] アルツハイマー病と糖尿病:認知症の治療標的の可能性2021

    • Author(s)
      大八木保政
    • Organizer
      第40回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] 皮膚の終末糖化産物(AGEs)蓄積は高齢男性のサルコペニアと関連する2021

    • Author(s)
      越智雅之、武井聖空、岡田陽子、伊賀瀬道也、大八木保政
    • Organizer
      第62回日本神経学会総会
    • Data Source
      KAKENHI-PROJECT-21K07390
  • [Presentation] アルツハイマー病マウス脳のPI3K-Aktシグナル障害とその治療薬の探索2021

    • Author(s)
      大八木保政、武井聡子、今村友裕
    • Organizer
      第39回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] アルツハイマー病のインスリンシグナリング障害モデルの培養細胞アッセイ系の確立と治療薬の探索2020

    • Author(s)
      大八木保政
    • Organizer
      第62回日本老年医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] Apomorphine treatment targeting neuronal insulin signaling in Alzheimer's disease.2020

    • Author(s)
      Ohyagi Y
    • Organizer
      International Conference on Complex Medical and Engineering (ICME) 2020
    • Data Source
      KAKENHI-PROJECT-20K07826
  • [Presentation] Apomorphine as a novel drug targeting neuronal insulin signaling in Alzheimer’s disease2019

    • Author(s)
      Ohyagi Y, Takei S, Nakamura N, Imamura T
    • Organizer
      144th Annual Meeting of The American Neurological Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] 糖尿病+アルツハイマー病モデルマウスの分子病態と治療薬の開発2019

    • Author(s)
      大八木保政
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] シンポジウム:糖尿病+アルツハイマー病モデルマウスの分子病態と治療薬の開発2019

    • Author(s)
      大八木 保政
    • Organizer
      第38回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] シンポジウム:アルツハイマー病における脳の糖尿病とアポモルフィン治療の可能性2019

    • Author(s)
      大八木 保政
    • Organizer
      第34回日本老年精神医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] アルツハイマー病における脳の糖尿病とアポモルフィン治療の可能性2019

    • Author(s)
      大八木保政
    • Organizer
      第34回日本老年精神医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] Impairment of insulin signaling by Alzheimer’s amyloid-β protein and protection by apomorphine2019

    • Author(s)
      大八木保政、武井聡子、岡部颯、花岡由理子、井手努、越智雅之、越智博文
    • Organizer
      第60回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] アルツハイマー病脳のインスリンシグナリング障害を改善する薬剤評価のための培養細胞アッセイ系の確立2018

    • Author(s)
      武井聡子、大八木保政、越智雅之、越智博文
    • Organizer
      第36回日本神経治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] Glucose intolerance associating with cognitive impairment and brain diabetes as a therapeutic target in Alzheimer's disease2017

    • Author(s)
      Ohyagi Y, Ohara M, Igase M, Nakamura N, Imamura T, Yanagihara YT, Kira J, Watanabe A, Fujii N
    • Organizer
      World Congress of Neurology
    • Place of Presentation
      京都市
    • Year and Date
      2017-09-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 3xTg-ADマウスの糖インスリン代謝異常はAβ毒性ターン形成を促進する2017

    • Author(s)
      大八木保政、今村友裕、柳原由記
    • Organizer
      第36回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] Apomorphine as a novel drug for Alzheimer's disease targeting brain diabetes2017

    • Author(s)
      Ohyagi Y, Nakamura N, Imamura T, Watanabe A, Fujii N
    • Organizer
      Neuroscience 2017
    • Place of Presentation
      Washington, DC, アメリカ合衆国
    • Year and Date
      2017-11-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] Glucose intolerance associating with mild cognitive impairment and brain diabetes as a therapeutic target in Alzheimer's disease2017

    • Author(s)
      Ohyagi Y, Ohara M, Igase M, Nakamura T, Imamura T, Yanagihara YT, Kira J, Watanabe A, Fujii N
    • Organizer
      World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] Apomorphine as a novel drug for Alzheimer's disease targeting brain diabetes2017

    • Author(s)
      Ohyagi Y, Nakamura N, Imamura T, Watanabe A, Fujii N
    • Organizer
      Neuroscience 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09302
  • [Presentation] アポモルフィン注射薬はADマウス脳のインスリン抵抗性を改善する2016

    • Author(s)
      大八木保政
    • Organizer
      第34回日本神経治療学会総会
    • Place of Presentation
      米子市
    • Year and Date
      2016-11-03
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] アポモルフィンはアルツハイマー病の記憶力とインスリン抵抗性を改善する2016

    • Author(s)
      大八木保政、他
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] Apomorphine improves memory function and insulin resistance in Alzheimer's disease2016

    • Author(s)
      Ohyagi Y, Watanabe A, Sasagasako N, Fujii N, Nakamura N, Kira J
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸市
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 大学病院ドック受検者における認知機能と糖インスリン代謝の解析2016

    • Author(s)
      大八木保政、尾原麻耶、伊賀瀬道也
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 一般中高年者における軽度認知障害と糖・インスリン代謝の解析2016

    • Author(s)
      尾原麻耶、大八木保政、他
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] Effects of peripheral insulin metabolism on toxic turn amyloid-β in 3xTg-AD mice2016

    • Author(s)
      Imamura T, Ohyagi Y, et al.
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] アルツハイマー型認知症に対するアポモルフィン治療のパイロット研究2015

    • Author(s)
      大八木保政、他
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森県青森市
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 非糖尿病アルツハイマー病患者における認知機能と末梢インスリン抵抗性の解析2015

    • Author(s)
      大八木保政、他
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2015-05-20
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] アルツハイマー病のインスリン抵抗性とアポモルフィン治療の開発2015

    • Author(s)
      大八木保政
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森県青森市
    • Year and Date
      2015-10-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] アルツハイマー型認知症に対するアポモルフィン治療のパイロット研究2015

    • Author(s)
      大八木保政、他
    • Organizer
      第33回日本神経治療学会総会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2015-11-26
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] グリア性炎症からみた筋萎縮性側索硬化症の脊髄白質変性に関する形態学的検証2013

    • Author(s)
      林信太郎、眞崎勝久、崔訳文、長柄祐子、大八木保政、岡本幸市、吉良潤一
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25461317
  • [Presentation] TDP-43(A315T) tgマウスの脊髄運動ニューロンにおける核細胞質間輸送障害の解析2013

    • Author(s)
      長柄祐子、林信太郎、山崎亮、大八木保政、吉良潤一
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-25461317
  • [Presentation] 孤発性筋萎縮性側索硬化症の脊髄白質に浸潤する免疫細胞群の特徴: 免疫組織化学的解析2013

    • Author(s)
      林信太郎、眞崎勝久、山崎亮、村井弘之、大八木保政、岡本幸市、吉良潤一
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Data Source
      KAKENHI-PROJECT-25461317
  • [Presentation] アルツハイマー型認知症の分子病態と治療戦略2013

    • Author(s)
      大八木保政
    • Organizer
      第86回日本薬理学会セミナー
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] アポモルフィンのglutathione peroxidase活性上昇作用とその分子機構の解明2012

    • Author(s)
      大八木保政
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] 神経細胞内アミロイドβの分子病態とアポモルフィン治療の開発2012

    • Author(s)
      大八木保政
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] 細胞内Aβの分子病態とアポモルフィン治療2012

    • Author(s)
      大八木保政
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Treatment with apomorphine and lithium in mice with Alzheimer's disease.2012

    • Author(s)
      Nakamura N, Ohyagi Y, et al:
    • Organizer
      42nd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-17
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Intracellular accumulation of toxic turn amyloid-β associated with endoplasmic reticulum stress in Alzheimer’s disease2012

    • Author(s)
      Yasumasa Ohyagi
    • Organizer
      42nd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      アメリカ合衆国ニューオリンズ
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] ADマウスにおけるアポモルフィンおよびリチウム治療とその作用機序の解析2012

    • Author(s)
      大八木保政
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば市
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Intracellular accumulation of toxic turn amyloid-β associated with endoplasmic reticulum stress in Alzheimer'sdisease.2012

    • Author(s)
      Ohyagi Y et al
    • Organizer
      42nd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] 細胞内アミロイドβおよび酸化ストレスを標的とする治療薬:アポモルフィン2011

    • Author(s)
      大八木保政
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Apomorphine treatment in Alzheimer mice promoting amyloid-βdegradation2011

    • Author(s)
      Ohyagi Y, et al
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease 2011
    • Place of Presentation
      フランス・パリ
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Apomorphine treatment in Alzheimer mice promoting amyloid-βdegradation2011

    • Author(s)
      Ohyagi Y et al
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] アルツハイマー病の新規治療薬~神経細胞内アミロイドβ蛋白および酸化ストレスを標的とするアポモルフィン~2011

    • Author(s)
      大八木保政
    • Organizer
      BioJapan World Business Forum
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] 細胞内アミロイドβの分子病態とアポモルフィン治療2011

    • Author(s)
      大八木保政、中村憲道、副島直子、姫野恵理、吉良潤一
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] 軽度認知機能障害(MCI)患者における並列的視覚路の機能変化2010

    • Author(s)
      山崎貴男, 堀江静, 姫野恵理, 大八木保政, 吉良潤一, 飛松省三
    • Organizer
      第15回認知神経科学会学術集会
    • Place of Presentation
      島根
    • Data Source
      KAKENHI-PROJECT-20591026
  • [Presentation] A new apomorphine therapy for Alzheimer's disease2010

    • Author(s)
      Ohyagi Y et al
    • Organizer
      135th Annual Meeting of American Neurological Association
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-09-14
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] A new apomorphine therapy for Alzheimer's disease2010

    • Author(s)
      Ohyagi Y, et al
    • Organizer
      135th Annual Meeting of American Neurological Association
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2010-09-14
    • Data Source
      KAKENHI-PROJECT-22590936
  • [Presentation] Enhancement of intracellular Aβ and p53 degradation : A novel therapeutic strategy of Alzheimer's disease2007

    • Author(s)
      Ohyagi, Y, Tabira, T, Kira, J
    • Organizer
      8 th International Conference on Progress in Alzheimer's and Parkinson's Disease
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      2007-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Presentation] アポモルフィンのプロテアソーム活性上昇作用と初代培養神経細胞の保護効果2007

    • Author(s)
      大八木 保政, ら
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Presentation] Effects of FAD-related mutant presenilin 1(PS1) on caspases activity and apoptosis : Implications in familial Alzheimer's pathogenesis2006

    • Author(s)
      Miyoshi, K, Ohyagi, Y, Motomura, K, Tabira, T, Kira, J
    • Organizer
      10th International Conference on Alzheimer's Disease and Related Disorders
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590948
  • [Presentation] Apomorphine treatment up-regulates IDE and Aβ degradation in 3xTg-AD mice

    • Author(s)
      Ohyagi Y, Nakamura N, Yanagihara Y, Iinuma K, Kira J
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] New Trends in Therapeutics for Alzheimer’s Disease (Symposium): A novel therapeutics for Alzheimer’s disease as type-3 diabetes

    • Author(s)
      Ohyagi Y
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] Apomorphine Therapy for Neuronal Insulin Resistance in Alzheimer Mice

    • Author(s)
      Ohyagi Y, Nakamura N, Yanagihara Y, Iinuma K, Kira J
    • Organizer
      26th International Conference of Alzheimer’s Association (AAIC)
    • Place of Presentation
      コペンハーゲン、デンマーク
    • Year and Date
      2014-07-12 – 2014-07-17
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] アルツハイマー病の末梢インスリン抵抗性と認知機能の解析

    • Author(s)
      柳原由記、大八木保政、中村憲道、川村有希子、吉良潤一
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 免疫細胞群からみた孤発性筋萎縮性側索硬化症の脊髄白質変性機序の再検討

    • Author(s)
      林信太郎、山崎亮、眞崎勝久、村井弘之、大八木保政、岡本幸市、吉良潤一
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-05-21 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-25461317
  • [Presentation] アルツハイマー病マウスの認知機能における末梢インスリン抵抗性の影響

    • Author(s)
      柳原由記、大八木保政、中村憲道、今村友裕、飯沼今日子、吉良潤一
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] 非糖尿病アルツハイマー病患者の認知機能における末梢インスリン抵抗性の影響

    • Author(s)
      大八木保政、柳原由記、中村憲道、川村有希子、吉良潤一
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461274
  • [Presentation] Apomorphine treatment improves neuronal insulin resistance in older 3xTg-AD mice

    • Author(s)
      Nakamura N, Ohyagi Y, Yanagihara Y, Iinuma K, Kira J
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-05-21 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-26461274
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    # of Collaborated Products: 12 results
  • 2.  KIRA Jun-ichi (40183305)
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 0 results
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  • 7.  HIWATASHI Akio (30444855)
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 7 results
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    # of Collaborated Products: 3 results
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