Yasutomo Koji 安友康二

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YASUTOMO Koji 安友康二

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Researcher Number	30333511
Other IDs
External Links
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(医学域), 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 徳島大学, 大学院医歯薬学研究部(医学域), 教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(医学系), 教授 2015 – 2017: 徳島大学, 大学院医歯薬学研究部, 教授 2014: 徳島大学, 大学院医ヘルスバイオサイエンス研究部, 教授 2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 教授 … More 2013: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2004 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 2008: 徳島大学, 大学院・ヘルスバイオサイエンス部, 教授 2006: The University of Tokushima, Institute of Health Biosciences, Professor, 徳島大学・大学院ヘルスバイオサイエンス研究部, 教授 2005 – 2006: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 2004: 徳島大学, ヘルスバイオサイエンス研究部, 教授 2001 – 2003: 徳島大学, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Pediatrics / Biological Sciences / Transformative Research Areas, Section (III) / Medium-sized Section 52:General internal medicine and related fields Except Principal Investigator Digestive surgery / Basic Section 55010:General surgery and pediatric surgery-related / General surgery / Biological Sciences / Transformative Research Areas, Section (III) / Immunology / Biological Sciences
Keywords	Principal Investigator Notch / Tリンパ球 / 癌 / CD4 / 糖鎖 / fringe / CD8 / T細胞 / ゲノム解析 / 樹状細胞 … More / 免疫療法 / 遺伝性疾患 / 肺線維症 / リガンド / 細胞傷害性機能 / 膠原病 / Jagged / 免疫寛容 / 病理学 / 細胞・組織 / 免疫学 / ヘルパーT細胞 / 自己抗原 / 免疫プロテアソーム / 感染 / プロテアソーム / エクソーム解析 / ウイルス感染 / 遺伝子改変マウス / B細胞 / 細菌感染 / 遺伝解析 / 免疫不全 / 免疫異常 / 免疫疾患 / サイトカイン / NLRC4 / エクソーム / 遺伝病 / 炎症 / ネクロプトーシス / パイロプトーシス / 細胞死 / 蕁麻疹 / 遺伝学 / 慢性炎症 / 細胞運命決定 / クロマチン / CHD / ヘリカーゼ / 分子標的治療 / 細胞治療 / 転写調節 / 自己免疫 / 自己免疫疾患 / 宿主寄生体相互作用 / 免疫回避 / 寄生虫感染 / 原虫感染 / リガンド結合 / 免疫応答 / 癌免疫応答 / 細胞療法 / 腫瘍免疫 / 発生・分化 / シグナル伝達 / 不死化 / アポトーシス / 内科 / レトロウイルスベクター / インターロイキン12 … More Except Principal Investigator 肝不全 / 脂肪由来幹細胞 / 調節性T細胞 / Notch / 肝細胞様細胞 / 肝再生 / 再生 / 炎症 / 細胞死 / 調節性T細胞 Treg / Notchシグナル / 加齢肝 / 免疫原性 / 免疫原生 / 脂肪由来間葉系幹細胞 / HLC / 超高機能肝細胞様細胞 / オルガノイド / 恒常性維持 / 自己認識 / 自己分子 / 免疫センサー / insulin-producing cell / 細胞運命 / 自己免疫 / 1型糖尿病 / IPC / 腸管関連 / NAFLD / NASH / 腸肝関連 / 脂肪組織 / 肝微小環境 / 脂肪肝炎 / 腸管上皮間リンパ球 / フリッパーゼ / マクロファージ / フリッパーセ / 上皮間リンパ球 / 免疫 / immunosupression / Deltal / Japped 1 / Jaeeed1 / 免疫抑制作用 / Delta1 / Jagged1 / splenectomy / NK cell / regulatory T cell / liver metastasis / FACS解析 / 宿側 / 免疫応答 / CD4+CD25+ Tcell / FoxP3 / 大腸癌 / 制御性T細胞 / 脾摘 / NK細胞 / 肝転移 / 肝星細胞 / 生体応答 / suppressor T細胞 / helper T細胞 / 脂肪由来幹細胞（ADSC） / VEGF signal / OP9DL1細胞 / homing効果 / trophic効果 / 免疫寛容 / 拒絶反応 / 膵島移植 / THBS-1 / CD47 / Jagged / Delta / Foxp3 / 術前放射線治療 / 直腸癌 / マイクロダイアライシス / 加齢遺伝子 / 幹細胞 / 大量肝切除術 / 虚血再潅流傷害 / 肝虚血再灌流傷害 / 脂肪肝 / 肝移植 / 調節性T 細胞 / 肝細胞癌 / 移植外科 / 細胞内寄生性病原体 / CTL / Th2 / Th1 / 細胞系譜決定 / 細胞分化 / Tリンパ球 Less

脂肪由来幹細胞ADSCから誘導した肝細胞様細胞HLCの免疫原性獲得に関する研究
- Principal Investigator
  
  齋藤裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
自己脂肪由来インスリン産生細胞自家移植における抗原性発現と細胞運命の研究
- Principal Investigator
  
  池本哲也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Understanding the molecular mechanims to sense self-peptides by the analysis of hereditary inflammatory disordersPrincipal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokushima
Self-referential immune perception
- Principal Investigator
  
  山崎晶
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
オルガノイドを用いた脂肪由来幹細胞からの超高機能肝細胞様細胞の確立
- Principal Investigator
  
  島田光生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Pathogenesis of pulmonary fibrosis with a novel animal modelPrincipal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokushima
Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis
- Principal Investigator
  
  SHIMADA Mitsuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Establishment of international research community on cell death
- Principal Investigator
  
  Tanaka Masato
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of maintenance mechanism of intestinal homeostasis through control of small intestinal epithelial lymphocytes by Notch signal
- Principal Investigator
  
  ISHIFUNE Chieko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokushima
Homeostatic regulation by various type of cell death
- Principal Investigator
  
  Tanaka Masato
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
Dysregulated cell death-associated human disordersPrincipal Investigator
- Principal Investigator
  
  YASUTOMO Koji
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Genetics of immunodefient syndrome to elucidate the human immune systemPrincipal Investigator
- Principal Investigator
  
  YASUTOMO Koji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokushima
Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.
- Principal Investigator
  
  SHIMADA Mitsuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokushima
ＣＨＤによるクロマチン構造制御が規定する細胞運命Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.
- Principal Investigator
  
  SHIMADA Mitsuo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Mechanism of distant metastasis after radiotherapy for rectal cancer.
- Principal Investigator
  
  HIGASHIJIMA Jun
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Investigation of immune tolerance in the islet transplantation using adipose tissue derived stem cell.
- Principal Investigator
  
  IWATA Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
異なるリガンド環境下において免疫細胞の恒常性を維持する分子基盤Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発
- Principal Investigator
  
  SHIMADA Mitsuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Establishment of autoimmune disease therapies based on the elucidation of target genesPrincipal Investigator
- Principal Investigator
  
  YASUTOMO Koji
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (S)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokushima
Notchシグナルによる抗寄生虫応答機構の解明Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Prevention of hepatocellular carcinoma recurrence after livertransplantation by managing regulatory T cells
- Principal Investigator
  
  YOSHIZUMI Tomoharu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyushu University
Notchリガンドによる抗腫瘍免疫療法の開発Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
異なるリガンド環境におけるTリンパ球応答の分子基盤Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Development of the new immunological tolerance induction which uses Notch ligands in islet transplantation
- Principal Investigator
  
  SOEJIMA Yuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokushima
Notchリガンドを用いた新規癌免疫療法の開発Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Notch分子の糖鎖修飾によるT細胞分化への影響Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
NotchシグナルによるTリンパ球活性化制御機構の解明Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
The role of regulatory T cells in the formation of cancer metastasis.
- Principal Investigator
  
  TERASHIMA Yoshiyasu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokushima
Notch分子によるヘルパーTリンパ球分化・活性化制御機構の解明
- Principal Investigator
  
  前川洋一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Jagged1を制御することによる癌免疫の増強に関する研究Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
NotchシステムによるTリンパ球活性化制御機構の解明とその臨床応用Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokushima
制御性T細胞を用いた抗腫瘍免疫の増強効果に関する研究Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Tリンパ球の生死を規定する分子機構の解明Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Notch-3によるヘルパーT細胞分化修飾機構の解明Principal Investigator
- Principal Investigator
  
  安友康二
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima

All 2023 2022 2021 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2005

All Journal Article Presentation Book

[Book] Notch signaling Immunity and Cancer-Notch and Myeloid Cells-2017
- Author(s)
  Chieko Ishifune and Koji Yasutomo
- Total Pages
  104
- Publisher
  Springer
- ISBN
  9789811049705
- Data Source
  KAKENHI-PROJECT-15K19131
[Book] 別冊　医学のあゆみレドックスUPDATE ストレス制御の臨床医学・健康科学2015
- Author(s)
  石舟智恵子　安友康二
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K19131
[Journal Article] MicroRNA-449a deficiency promotes colon carcinogenesis2017
- Author(s)
  Niki Masanori、Nakajima Kohei、Ishikawa Daichi、Nishida Jun、Ishifune Chieko、Tsukumo Shin-ichi、Shimada Mitsuo、Nagahiro Shinji、Mitamura Yoshinori、Yasutomo Koji
- Journal Title
  
  Scientific Reports
  
  Volume: 7（1） Issue: 1 Pages: 10696-10696
- DOI
  10.1038/s41598-017-10500-0
- NAID
  120006535013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H07015, KAKENHI-PROJECT-15K08307, KAKENHI-PROJECT-15K19131
[Journal Article] Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by RegulatingAldh1a2Expression2017
- Author(s)
  Zaman Taskia Sultana、Arimochi Hideki、Maruyama Satoshi、Ishifune Chieko、Tsukumo Shin-ichi、Kitamura Akiko、Yasutomo Koji
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 6 Pages: 1989-1997
- DOI
  10.4049/jimmunol.1700645
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26110008, KAKENHI-PROJECT-15K19131
[Journal Article] Transmission of survival signals through Delta-like 1 on activated CD4+ T cells2016
- Author(s)
  Furukawa T, Ishifune C, Tsukumo S, Hozumi K, Maekawa Y, Matsui N, Kaji R, Yasutomo K
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 33692-33692
- DOI
  10.1038/srep33692
- NAID
  120006534968
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04724, KAKENHI-PROJECT-26450401, KAKENHI-PROJECT-15K19131, KAKENHI-PROJECT-16K15524
[Journal Article] Differentiation of preadipocytes and mature adipocytes requires PSMB82016
- Author(s)
  Arimochi H, Sasaki Y, Kitamura A, Yasutomo K.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 26791-26791
- DOI
  10.1038/srep26791
- NAID
  120006534960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26110008, KAKENHI-PROJECT-26350123
[Journal Article] Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.2016
- Author(s)
  Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseno CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1
- DOI
  10.1038/ncomms12597
- NAID
  120006535058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19131
[Journal Article] Notch controls the persistence of autoimmune memory CD4+ T cells by maintaining glucose uptake.2015
- Author(s)
  Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K.
- Journal Title
  
  Nature Medicine
  
  Volume: 21 Issue: 1 Pages: 55-61
- DOI
  10.1038/nm.3758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590585, KAKENHI-PROJECT-26290059, KAKENHI-PROJECT-15K19131, KAKENHI-PLANNED-26110008, KAKENHI-PROJECT-26253063
[Journal Article] CD98 heavy chain Is a potent positive regulator of CD4+ T cell proliferation and interferon-γ production in vivo.2015
- Author(s)
  Kurihara T, Arimochi H, Bhuyan ZA, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Maekawa Y, YasutomoK.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0139692-e0139692
- DOI
  10.1371/journal.pone.0139692
- NAID
  120006871194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19131, KAKENHI-PROJECT-15H04724
[Journal Article] Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.2015
- Author(s)
  Oh SJ, Ahn S, Jin YH, Ishifune C, Kim JH, Yasutomo K, and Chung DH.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 98 Issue: 5 Pages: 781-789
- DOI
  10.1189/jlb.1a0914-459rr
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19131
[Journal Article] Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells2014
- Author(s)
  Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K
- Journal Title
  
  PLoS One
  
  Volume: 9(2) Issue: 2 Pages: e89266-e89266
- DOI
  10.1371/journal.pone.0089266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390324, KAKENHI-PROJECT-24590585, KAKENHI-PROJECT-26293288
[Journal Article] The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+cells2013
- Author(s)
  Nakajima K, Maekawa Y, KataokaK, IshifuneC, NishidaJ, ArimochiH, KitamuraA, YoshimotoT, TomitaS, NagahiroS, Yasutomo K
- Journal Title
  
  Nature Communications
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice2012
- Author(s)
  ian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 5 Pages: 2227-34
- DOI
  10.4049/jimmunol.1102586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23791179
[Journal Article] Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity.2012
- Author(s)
  Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11 Issue: 12 Pages: 2578-2587
- DOI
  10.1158/1535-7163.mct-12-0640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501048, KAKENHI-PROJECT-24390210, KAKENHI-PROJECT-24590585
[Journal Article] Notch2 regulates the development of marginal zone B cells through Fos2012
- Author(s)
  Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoko K, Chiba S, Shimada M, Yasutomo K
- Journal Title
  
  iochem Biophys Res Commun
  
  Volume: 418 Issue: 4 Pages: 701-707
- DOI
  10.1016/j.bbrc.2012.01.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-23390324, KAKENHI-PROJECT-23500958, KAKENHI-PROJECT-23791179, KAKENHI-PROJECT-24890146
[Journal Article] Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus2011
- Author(s)
  Ishifune C, et al
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Issue: 5 Pages: 1309-20
- DOI
  10.1002/eji.201041159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09121, KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23790350
[Journal Article] Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production2011
- Author(s)
  M.Xu
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Issue: 10 Pages: 2828-2839
- DOI
  10.1002/eji.201141291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-23659626
[Journal Article] Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic Cells.2011
- Author(s)
  Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW
- Journal Title
  
  Int Arch Allergy Immunol
  
  Volume: 157 Issue: 1 Pages: 65-72
- DOI
  10.1159/000324836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011
- Author(s)
  Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito T, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
- Journal Title
  
  Blood
  
  Volume: 117 Issue: 1 Pages: 128-134
- DOI
  10.1182/blood-2010-07-289611
- NAID
  120007137632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-22500760, KAKENHI-PROJECT-23591369
[Journal Article] A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans2011
- Author(s)
  Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Issue: 10 Pages: 4150-4160
- DOI
  10.1172/jci58414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21570169, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23591236, KAKENHI-PROJECT-23657083, KAKENHI-PROJECT-23791179
[Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo2010
- Author(s)
  Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K
- Journal Title
  
  J Immunol
  
  Volume: 184 Issue: 9 Pages: 4673-4678
- DOI
  10.4049/jimmunol.0903661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-22240089
[Journal Article] Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.2010
- Author(s)
  Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 107 Issue: 13 Pages: 5943-5948
- DOI
  10.1073/pnas.0911755107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536
[Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese2010
- Author(s)
  Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Mo
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 69 Issue: 2 Pages: 368-373
- DOI
  10.1136/ard.2008.104315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-15.2009
- Author(s)
  Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
- Journal Title
  
  J Immunol
  
  Volume: 182 Issue: 10 Pages: 6168-6178
- DOI
  10.4049/jimmunol.0803036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Gelfand EW. Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.2009
- Author(s)
  Okamoto M, Matsuda H, Lucas JL, Domenico J, Yasutomo K, Takeda K
- Journal Title
  
  J Immunol
  
  Volume: 183 Issue: 5 Pages: 2995-3003
- DOI
  10.4049/jimmunol.0900692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.2009
- Author(s)
  Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K
- Journal Title
  
  J Immunol
  
  Volume: 182 Issue: 6 Pages: 3566-3572
- DOI
  10.4049/jimmunol.0803765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Journal Article] Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.2005
- Author(s)
  Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K
- Journal Title
  
  Nature Immunology
  
  Volume: 9 Issue: 10 Pages: 1140-1147
- DOI
  10.1038/ni.1649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005
[Presentation] 遺伝性疾患研究から探る慢性炎症の基盤メカニズム2023
- Author(s)
  安友康二
- Organizer
  日本免疫学会免疫サマースクール2023,
- Invited
- Data Source
  KAKENHI-PROJECT-21H04819
[Presentation] Cell death in pulmonary fibrosis2023
- Author(s)
  安友康二
- Organizer
  Japan and Australia Meeting on Cell Death
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05188
[Presentation] 遺伝性疾患研究から探る慢性炎症の基盤メカニズム2023
- Author(s)
  安友康二
- Organizer
  日本免疫学会免疫サマースクール
- Invited
- Data Source
  KAKENHI-PLANNED-22H05188
[Presentation] Immunodeficiency and autoinflammation caused by dysfunction of immunoproteasomes2023
- Author(s)
  安友康二
- Organizer
  JSICR/MMCB
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05188
[Presentation] プロテアソーム機能低下と免疫発生・制御不全2023
- Author(s)
  佐々木由紀、安友康二
- Organizer
  53.第6回日本免疫不全・自己炎症学会総会・学術集会　基礎研究シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-22H05188
[Presentation] プロテアソーム機能不全と自己炎症疾患2022
- Author(s)
  安友康二
- Organizer
  52.第54回小児感染症学会総会・学術集会　シンポジウム「自己炎症性疾患の最新知見」
- Invited
- Data Source
  KAKENHI-PLANNED-22H05188
[Presentation] 慢性炎症の基盤メカニズムを紐解く鍵の探索2022
- Author(s)
  安友康二
- Organizer
  日本免疫学会免疫サマースクール
- Invited
- Data Source
  KAKENHI-PROJECT-21H04819
[Presentation] 肺線維症のゲノム解析から紐解く肺線維化の分子メカニズム2021
- Author(s)
  安友康二
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04819
[Presentation] Notch signal controls the number of TCRab+CD8aa+ intraepithelial lymphocytes via phospholipid asymmetry by maintaining flippase ATP8a22017
- Author(s)
  Chieko Ishifune, Yoichi Maekawa, Shin-ichi Tsukumo and Koji Yasutomo
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] Notchシグナルによる細胞膜リン脂質の極性制御を介した腸管上皮間リンパ球の制御2017
- Author(s)
  石舟智恵子, 安友康二
- Organizer
  第32回自己免疫研究会
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] Notch-STAT5b is central for the development of TCR alpha beta+ CD8 alpha alpha+ small intestinal intraepithelial lymphocytes2016
- Author(s)
  Chieko Ishifune, Yoichi Maekawa, Katsuto Hozumi and Koji Yasutomo
- Organizer
  16th International Congress of Immunology (ICI)
- Place of Presentation
  メルボルン（オーストラリア）
- Year and Date
  2016-08-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] Notch-Rbpj controls TCR alpha beta+ CD8 alpha alpha+ intraepithelial lymphocytes by maintaining fllipase ATP8a22016
- Author(s)
  Chieko Ishifune, Yoichi Maekawa, Shin-ichi Tsukumo and Koji Yasutomo
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] Notch-STAT5b is central for the differentiation of TCR alpha beta+ CD8 alpha alpha+ intraepithelial lymphocytes.2015
- Author(s)
  Chieko Ishifune, Yoichi Maekowa, Katsuto Hozumi and Koji Yasutomo
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] Notch-STAT5b Signaling Regulates the TCR alpha beta+ CD8 alpha alpha+ Intraepithelial Lymphocytes in the Small Intestine,2015
- Author(s)
  Chieko Ishifune and Koji Yasutomo
- Organizer
  17th International Congress of Mucosal Immunology
- Place of Presentation
  Maritim Hotel Berlin　(ベルリン、ドイツ）
- Year and Date
  2015-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19131
[Presentation] 免疫プロテアソーム機能異常による炎症応答の分子基盤2012
- Author(s)
  安友康二
- Organizer
  日本生化学学会シンポジウム
- Place of Presentation
  福岡県
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-20679005
[Presentation] Notch provides metabolic signals in memory CD4+ T cells2012
- Author(s)
  Koji Yasutomo
- Organizer
  日本免疫学会シンポジウム
- Place of Presentation
  神戸国際会議場、兵庫県
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-20679005
[Presentation] Notchシグナルによるリンパ球機能制御2010
- Author(s)
  安友康二
- Organizer
  宮崎サイエンスキャンプ
- Place of Presentation
  シェラトン・グランデ・オーシャンリゾート(宮崎)
- Year and Date
  2010-02-28
- Data Source
  KAKENHI-PROJECT-20679005
[Presentation] Notch signaling controls T cell cytotoxicity2009
- Author(s)
  安友康二
- Organizer
  日本免疫学会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20057018
[Presentation] Notch signaling controls T cell cytotoxicity2009
- Author(s)
  安友康二
- Organizer
  日本免疫学会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20679005
[Presentation] Notchシグナルによる免疫制御2008
- Author(s)
  安友康二
- Organizer
  自己免疫疾患研究会
- Place of Presentation
  東京、霞ヶ関ビル内「東海大学学友会館」
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-20679005

1. IKEMOTO Tetsuya (20398019)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. SHIMADA Mitsuo (10216070)

# of Collaborated Projects: 9 results

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# of Collaborated Projects: 8 results

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17. HIGASHIJIMA Jun (30467815)

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28. YOSHIZUMI Tomoharu (80363373)

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Yasutomo Koji 安友 康二

YASUTOMO Koji 安友 康二

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Understanding the molecular mechanims to sense self-peptides by the analysis of hereditary inflammatory disordersPrincipal Investigator

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Pathogenesis of pulmonary fibrosis with a novel animal modelPrincipal Investigator

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Dysregulated cell death-associated human disordersPrincipal Investigator

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Genetics of immunodefient syndrome to elucidate the human immune systemPrincipal Investigator

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ＣＨＤによるクロマチン構造制御が規定する細胞運命Principal Investigator

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Yasutomo Koji 安友康二

YASUTOMO Koji 安友康二