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yamashita tatsuya  山下 竜也

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Yamashita Tatsuya  山下 竜也

山下 竜也  ヤマシタ タツヤ

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Researcher Number 30334783
Other IDs
External Links
Affiliation (Current) 2022: 金沢大学, 先進予防医学研究センター, 准教授
Affiliation (based on the past Project Information) *help 2017 – 2022: 金沢大学, 先進予防医学研究センター, 准教授
2007: Kanazawa University, 医学部附属病院, 助教
2006: 金沢大学, 医学部附属病院, 助手
2003 – 2004: 金沢大学, 医学部附属病院, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Complex systems / Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
遺伝子治療 / レンチウイルスベクター / 肝炎ウイルス / 癌遺伝子治療 / アデノウイルス / 単球走化因子(MCP-1) / レンチウイルス / アデノウイルスベクター / p53 / IL-12 … More / マウス樹状細胞 / 肝癌培養細胞 / 5-FU / 肝細胞がん / がん幹細胞 / がんエコシステム / CCL20 / CCR6 / CCL20/CCR6 / 1細胞トランスクリプトーム解析 / 肝癌 / 循環癌間質細胞 … More
Except Principal Investigator
単純性脂肪肝 / 脂肪性肝炎 / 肝硬変 / 肝線維化 / ヒドロキシノネナール / Hsp70.1 / カルパイン / カテプシン / リソソーム / ランゲルハンス島 / β細胞 / μ-カルパイン / GPR109A / ペルオキシゾーム / 細胞死 / 生活習慣病 / ニホンザル / 視床下部 / 肝臓 / 膵臓 / アルツハイマー病 / 非アルコール性脂肪性肝炎 / 2型糖尿病 / カルパインーカテプシン仮説 / サラダ油 Less
  • Research Projects

    (6 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (34 People)
  •  肝がんにおける循環癌間質細胞の特性と臨床的意義の探索Principal Investigator

    • Principal Investigator
      山下 竜也
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Cooking oil-derived hydroxynonenal and lifestyle-related diseases

    • Principal Investigator
      山嶋 哲盛
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kanazawa University
  •  Search for novel therapeutic target molecules based on the analysis of cancer ecosystem in liver cancerPrincipal Investigator

    • Principal Investigator
      Yamashita Tatsuya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kanazawa University
  •  Elucidation of inflammation cellular society in liver cirrhosis

    • Principal Investigator
      KANEKO Shuichi
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Kanazawa University
  •  肝癌化学療法に対する遺伝子治療併用の基礎的研究Principal Investigator

    • Principal Investigator
      山下 竜也
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University
  •  肝癌免疫遺伝子治療ウイルスベクターの基礎的研究Principal Investigator

    • Principal Investigator
      山下 竜也
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kanazawa University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma2021

    • Author(s)
      T Yamashita, N Koshikawa, T Shimakami, T Terashima, M Nakagawa, K Nio, R Horii, N Iida, K Kawaguchi, K Arai, Y Sakai, T Yamashita, E Mizukoshi, M Honda, A Kitao, S Kobayashi, S Takahara, Y Imai, K Yoshimura, T Murayama, Y Nakamoto, E Yoshida, T Yoshimura, M Seiki, S Kaneko.
    • Journal Title

      Hepatology.

      Volume: - Pages: 760-775

    • DOI

      10.1002/hep.31758

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H04823, KAKENHI-PROJECT-17H01886, KAKENHI-PROJECT-21H02900, KAKENHI-PROJECT-20K16984
  • [Journal Article] CX3CL1-CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice.2021

    • Author(s)
      Nagashimada Mayumi、Sawamoto Kazuki、Ni Yinhua、Kitade Hironori、Nagata Naoto、Xu Liang、Kobori Masuko、Mukaida Naofumi、Yamashita Tatsuya、Kaneko Shuichi、Ota Tsuguhito
    • Journal Title

      Endocrinology

      Volume: -

    • DOI

      10.1210/endocr/bqab064

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393
  • [Journal Article] CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice.2021

    • Author(s)
      Xu Liang、Chen Yongping、Nagashimada Mayumi、Ni Yinhua、Zhuge Fen、Chen Guanliang、Li Haoran、Pan Tongtong、Yamashita Tatsuya、Mukaida Naofumi、Kaneko Shuichi、Ota Tsuguhito、Nagata Naoto
    • Journal Title

      Metabolism

      Volume: 125 Pages: 154914-154914

    • DOI

      10.1016/j.metabol.2021.154914

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393
  • [Journal Article] Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.2021

    • Author(s)
      Isobe Yuki、Asakura Hiroki、Tsujiguchi Hiromasa、Kannon Takayuki、Takayama Hiroaki、Takeshita Yumie、Ishii Kiyo-aki、Kanamori Takehiro、Hara Akinori、Yamashita Tatsuya、Tajima Atsushi、Kaneko Shuichi、Nakamura Hiroyuki、Takamura Toshinari
    • Journal Title

      Front Nutr

      Volume: 8 Pages: 633703-633703

    • DOI

      10.3389/fnut.2021.633703

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19KK0237, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18K19560
  • [Journal Article] Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases2020

    • Author(s)
      Tetsumori Yamashima, Eishiro Mizukoshi, Hiroyuki Nakamura, Yasuhiko Yamamoto, Mitsuru Kikuchi, Tatsuya Yamashita, Shuichi Kaneko
    • Journal Title

      Advances in Nutrition

      Volume: 11 Pages: 1489-1509

    • DOI

      10.1093/advances/nmaa072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H04029, KAKENHI-PROJECT-18K06889
  • [Journal Article] Vegetable Oil-derived ‘Hydroxynonenal’ Causes Diverse Cell Death Possibly Leading to Alzheimer’s and Related Lifestyle Diseases2020

    • Author(s)
      Tetsumori Yamashima, Piyakarn Boontem, Hiroki Shimizu, Tsuguhito Ota, Mitsuru Kikuchi, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
    • Journal Title

      Journal of Alzheimer's Disease & Parkinsonism

      Volume: 10.1 Pages: 1-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H04029
  • [Journal Article] 2.Fatty acid-driven modifications in T-cell profiles in non-alcoholic fatty liver disease patients.2020

    • Author(s)
      T Seike, E Mizukoshi, K Yamada, H Okada, M Kitahara, T Yamashita, K Arai, T Terashima, N Iida, K Fushimi, T Yamashita, Y Sakai, M Honda, K Harada, S Kaneko.
    • Journal Title

      Journal of Gastroenterology

      Volume: - Pages: 701-711

    • DOI

      10.1007/s00535-020-01679-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-19K17455, KAKENHI-PROJECT-19K17485
  • [Journal Article] Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.2020

    • Author(s)
      Nishikawa Tomoki、Nagata Naoto、Shimakami Tetsuro、Shirakura Takashi、Matsui Chieko、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagashimada Mayumi、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi、Ota Tsuguhito
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 815-815

    • DOI

      10.1038/s41598-020-57784-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H04047
  • [Journal Article] Serum C16:1n7/C16:0 ratio as a diagnostic marker for nonalcoholic steatohepatitis2019

    • Author(s)
      K Yamada, E Mizukoshi, T Seike, R Horii, T Terashima, N Iida, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, T Takamura, K Harada, S Kaneko.
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 34 Pages: 1829-1835

    • DOI

      10.1111/jgh.14654

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04058, KAKENHI-PROJECT-18H02793
  • [Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity2019

    • Author(s)
      Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
    • Journal Title

      Cell Host Microbe.

      Volume: 10;25(4) Pages: 588-301

    • DOI

      10.1016/j.chom.2019.02.015

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-19K17427, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09413
  • [Journal Article] Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation.2019

    • Author(s)
      Yamato Masatoshi、Sakai Yoshio、Mochida Hatsune、Kawaguchi Kazunori、Takamura Masayuki、Usui Soichiro、Seki Akihiro、Mizukoshi Eishiro、Yamashita Taro、Yamashita Tatsuya、Ishida Kousuke、Nasti Alessandro、Tuyen Ho Thuy Bich、Komura Takuya、Yoshida Keiko、Wada Takashi、Honda Masao、Kaneko Shuichi
    • Journal Title

      J Gastroenterol Hepatol

      Volume: - Pages: 1432-1440

    • DOI

      10.1111/jgh.14647

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06394, KAKENHI-PROJECT-16K09425, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-17K09413
  • [Journal Article] Serum aldo?keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis2019

    • Author(s)
      M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
    • Journal Title

      J Gastroenterol.

      Volume: - Pages: 549-557

    • DOI

      10.1007/s00535-019-01551-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414
  • [Journal Article] Characteristics of Immune Response to Tumor-Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma2019

    • Author(s)
      Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida, M Kitahara, T Yamashita, K Arai, T Terashima, K Fushimi, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      Hepatology

      Volume: 69 Pages: 653-665

    • DOI

      10.1002/hep.30212

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16H04695
  • [Journal Article] Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models2019

    • Author(s)
      Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, Takabatake H, Yamato M, Yamashita T, Yamashita T, Mizukoshi E, Okuzono M, Ho TTB, Kawaguchi K, Wada T, Honda M, Kaneko S.
    • Journal Title

      Cancer Sci.

      Volume: 110 Pages: 903-912

    • DOI

      10.1111/cas.13944

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793
  • [Journal Article] Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.2018

    • Author(s)
      Kida A, Mizukoshi E, Tamai T, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Kaneko S.
    • Journal Title

      Liver International

      Volume: 38 Pages: 2040-2050

    • DOI

      10.1111/liv.13885

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15934, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793
  • [Journal Article] Immune responses to human telomerase reverse transcriptase-derived helper T cell epitopes in hepatocellular carcinoma patients.2018

    • Author(s)
      Kumagai Masashi、Mizukoshi Eishiro、Tamai Toshikatsu、Kitahara Masaaki、Yamashita Tatsuya、Arai Kuniaki、Terashima Takeshi、Iida Noriho、Fushimi Kazumi、Kaneko Shuichi
    • Journal Title

      Liver Int

      Volume: 印刷中 Pages: 1635-1645

    • DOI

      10.1111/liv.13713

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15934, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046
  • [Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication2018

    • Author(s)
      Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 13143-13143

    • DOI

      10.1038/s41598-018-31421-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-18K19538, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-18H02792, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K08579, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-16H04695
  • [Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.2017

    • Author(s)
      Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
    • Journal Title

      Oncotarget.

      Volume: 8 Pages: 39978-39993

    • DOI

      10.18632/oncotarget.18116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
  • [Presentation] 幹細胞性肝癌のがん微小環境を標的としたCCL20中和抗体の治療効果検討2020

    • Author(s)
      丹尾 幸樹,山下 太郎,金子 周一
    • Organizer
      第106回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-18K07998
  • [Presentation] 肝細胞癌の新規バイオマーカーとしてのCCL20の検討2019

    • Author(s)
      丹尾幸樹、山下太郎、山下竜也、金子周一
    • Organizer
      第55回日本肝がん研究会 ワークショップ8「新規バイオマーカー」
    • Data Source
      KAKENHI-PROJECT-18K07998
  • [Presentation] CCL20 blockade suppresses tumor growth by inhibiting recruitment of CCR6-positive immune suppressor cells in hepatic stem cell-like hepatocellular carcinoma2019

    • Author(s)
      Kouki Nio, Taro Yamashita, Mika Owada, Hikari Okada, Tatsuya Yamashita, Shuichi Kaneko
    • Organizer
      American Association for the Study of Liver Disease Annual Meeting Abstract no. 1844
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07998
  • 1.  KANEKO Shuichi (60185923)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 2.  本多 政夫 (00272980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 3.  山下 太郎 (90377432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  山嶋 哲盛 (60135077)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  及川 伸二 (10277006)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  丹尾 幸樹 (80807397)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ISHII Kiyoaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  TAKAMURA Toshinari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  OTA Tsuguhito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  WADA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  KAWAGUCHI Kazunori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  中本 安成
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  高原 志津子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  原 丈介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  寺島 健志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  山本 靖彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  永島田 まゆみ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 18.  酒井 佳夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 19.  白崎 尚芳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 20.  岡田 光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 21.  島上 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  北原 征明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  水腰 英四郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 24.  原田 憲一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  竹下 有美枝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  村居 和寿
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  御簾 博文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  坂井 宣彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  高村 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  田嶋 敦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  辻口 博聖
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  鈴木 亮介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  鈴木 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  善岡 克次
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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