Adachi Makoto 足立誠

… Alternative Names

ADACHI Makoto 足立誠

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Researcher Number	30335244
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 助教 2016 – 2021: 京都大学, 医学研究科, 助教 2018: 京都大学, 大学院医学研究科, 助教 2011 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 大学院・医学研究科, 助教 … More 2009: 京都大学, 大学院・医学研究科, 助手 2008: Kyoto University, 大学院・医学研究科, 助教 2007 – 2008: Kyoto University, 医学研究科, 助教 2002 – 2006: 京都大学, 医学研究科, 助手 2004: Kyoto University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Cell biology / Cell biology Except Principal Investigator Biological Sciences / Basic Section 48040:Medical biochemistry-related / Biological Sciences / Pathological medical chemistry
Keywords	Principal Investigator 細胞質分裂 / 細胞内シグナル伝達 / 細胞増殖 / タイトジャンクション / 上皮細胞 / 極性形成 / 細胞内シグナル伝達機構 / 癌 / 遺伝子発現制御 / X線結晶構造解析 … More / 接着構造形成 / 細胞接着 / 細胞内・細胞間情報伝達 / 基質 / キナーゼ / 極性 / ホスファターゼ / aPKC … More Except Principal Investigator クローディン / タイトジャンクション / 上皮細胞 / ZO-1 / 細胞間接着 / knockout mouse / epidermal barrier / occludin / claudin / tight junction / cell-cell adhesion / PDZドメイン / 血液脳関門 / ノックアウト / ZO-2 / ノックアウトマウス / 上皮間バリアー / オクルディン / メルリン / ERM蛋白質 / がん / ERM / アドヘレンスジャンクション / 細胞接着 / リガンド開発 / 計算科学 / クライオ電子顕微鏡単粒子解析 / プロテアーゼ活性化受容体 / Gタンパク質共役受容体 / TJ-MAPs / TJ-ストランド / アピカル細胞骨格 / TJ-アピカル複合体 / 細胞間バリア / TJストランド / クライオ電顕 / アピカル骨格 / TJMAP / 液-液相分離（LLPS） / アピカル膜 / クライオ電顕トモグラフィー / 細胞骨格 / 上皮バリア / compartment / blood-brain barrier / 裏打ち蛋白質 / Zo-1 / 血管 / バリアー / 内皮細胞 / コンパートメント / cell proliferation / ERM proteins / カドヘリン / β-カテニン / α-カテニン / ラディキシン / 大腸癌 / MUPP1 / ドラッグデリバリー / GFP / 転移浸潤 / 上皮間葉転換 / Snail / 細胞増殖 / トリセルリン / アドへレンスジャンクション / マーリン / ユビキチン化 / 近位尿細管 / 腸管バリア / 血管内皮細胞 Less

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers
- Principal Investigator
  
  月田早智子
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo University
  Osaka University
Elucidation of novel signaling mechanisms that regulates cell proliferation and divisionPrincipal Investigator
- Principal Investigator
  
  ADACHI Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Analysis of novel signaling pathways that regulate mammalian cell cytokinesisPrincipal Investigator
- Principal Investigator
  
  adachi makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Analysis of a novel signaling network that regulates cell growth and divisionPrincipal Investigator
- Principal Investigator
  
  ADACHI Makoto
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Functional analysis of novel components that localize to cell-cell adhesive structures in epithelial cellsPrincipal Investigator
- Principal Investigator
  
  ADACHI Makoto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Molecular mechanisms of cell-cell adhesion in cancer cells
- Principal Investigator
  
  FURUSE Mikio
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
  Kyoto University
上皮細胞の極性形成に関与するaPKCの生理的基質の探索Principal Investigator
- Principal Investigator
  
  足立誠
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University
Claudins in the epithelium/endothelium barrier dysfucrition
- Principal Investigator
  
  TSUKITA Shoichiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanism for cell-cell adhesion in canceration and metastasis
- Principal Investigator
  
  TSUKITA Shoichiro
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  KYOTO UNIVERSITY

All 2021 2020 2014 2013 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] Multicellular modeling of ciliopathy by combining ips cells and microfluidic airway-on-a-chip technology2021
- Author(s)
  Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa YS, Gotoh S.
- Journal Title
  
  Sci Transl Med.
  
  Volume: 13 Issue: 601
- DOI
  10.1126/scitranslmed.abb1298
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09886, KAKENHI-PROJECT-19H05468
[Journal Article] Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair2020
- Author(s)
  Matsuo Junichi、Douchi Daisuke、、Adachi Makoto、Tamura Atsushi、、Tsukita Sachiko、Ito Yoshiaki
- Journal Title
  
  Gut
  
  Volume: 70 Issue: 10 Pages: 1833
- DOI
  10.1136/gutjnl-2020-322779
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-19H05468
[Journal Article] Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis2014
- Author(s)
  Makoto Adachi, Asami Kawasaki, Hisashi Nojima, Eisuke Nishida and Sachiko Tsukita
- Journal Title
  
  Genes to Cells
  
  Volume: 19 Issue: 11 Pages: 803
- DOI
  10.1111/gtc.12179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460362, KAKENHI-PROJECT-25870251, KAKENHI-PLANNED-24113002, KAKENHI-PROJECT-24247037
[Journal Article] Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.2013
- Author(s)
  Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H
- Journal Title
  
  Curr. Biol.
  
  Volume: 23 Issue: 13 Pages: 1181-1194
- DOI
  10.1016/j.cub.2013.05.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21116003, KAKENHI-PLANNED-21116004, KAKENHI-PLANNED-23112003, KAKENHI-PROJECT-23247036, KAKENHI-PROJECT-25440112, KAKENHI-PROJECT-25460362
[Journal Article] Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight Junction Proteins2009
- Author(s)
  Adachi, et al.
- Journal Title
  
  Mol Cell Biol 29(昨年度報告書で印刷中と記載したもの)
  
  Pages: 2372-2389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins2009
- Author(s)
  Adachi, M., Hamazaki,Y., Kobayashi, Y., Itoh, M., Tsukita, S., Furuse
- Journal Title
  
  Mol. Cell. Biol 29
  
  Pages: 2372-2389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770168
[Journal Article] Similar and distinct properties of MUPP1 and PaTJ, two homologous PDZ domain-containing tight-junction proteins.2009
- Author(s)
  Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S.
- Journal Title
  
  Mol Cell Biol 29
  
  Pages: 2372-2389
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] IQGAP3 regulates cell proliferation through Ras-ERK signaling cascade2008
- Author(s)
  Nojima, H., Adachi, M., Matsui, T., Okawa, K., Tsukita, S. and Tsukita
- Journal Title
  
  Nat. Cell Biol 10
  
  Pages: 971-978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770168
[Journal Article] IAGAP3 regulates cell proliferation through the Ras/ERK signalling cascade2008
- Author(s)
  Nojima, H., Adachi, M., Masui, T., Okawa, K., Tsukita, S., Tsukita, S.
- Journal Title
  
  Nat. Cell Biol. 10
  
  Pages: 971-978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770168
[Journal Article] Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.2008
- Author(s)
  Matsuda M, Kobayashi Y, Masuda S, Adachi M, Watanabe T, Yamashita JK, Nishi E, Tsukita S, Furuse M.
- Journal Title
  
  Exp Cell Res 314
  
  Pages: 939-949
- NAID
  120001384679
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning2008
- Author(s)
  Matsuda, M., Kobayash, Y., Masuda, S., Adachi, M., Watanabe, T., Yamashita, J. K., Nishi, E., Tsukita, S., Furuse, M.
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 939-949
- NAID
  120001384679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770168
[Journal Article] Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/PaTJ and their endogenous properties.2007
- Author(s)
  Sugihara-Mizuno Y, Adachi M, Kobayashi Y, Hamazaki Y, Nishimura M, Imai T, Furuse M, Tsukita S.
- Journal Title
  
  Genes Cells 12
  
  Pages: 473-486
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.2006
- Author(s)
  Adachi, M.
- Journal Title
  
  Mol Cell Biol. 26
  
  Pages: 9003-9015
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.2006
- Author(s)
  Adachi M, Inoko A, Hata M, Furuse K, Umeda K, Itoh M, Tsukita S.
- Journal Title
  
  Mol Cell Biol 26
  
  Pages: 9003-9015
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight Junction Proteins
- Author(s)
  Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S
- Journal Title
  
  Mol Cell Biol (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014044
[Journal Article] Polarity-dependent distribution of angiomotin localizes Hipposignaling in preimplantation embryos
- Author(s)
  Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcon, V.B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., Ohno, M., Marikawa, Y.,Nakao, K., Shimono, A. and Sasaki, H
- Journal Title
  
  Curr. Biol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23790331
[Presentation] 哺乳類細胞における細胞質分裂へのIQGAPファミリー分子の関与2013
- Author(s)
  足立　誠
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場1号館1階
- Data Source
  KAKENHI-PROJECT-25460362
[Presentation] タイトジャンクションに局在する2つの類似したPDZドメイン含有分子MUPP1とPatjの解析.2007
- Author(s)
  足立誠、浜崎洋子、小林由佳、月田早智子、古瀬幹夫、月田承一郎
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17014044
[Presentation] タイトジャンクションに局在する2つの類似したPDZドメイン含有分子MUPPlとPatjの解析2007
- Author(s)
  足立誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19770168
[Presentation] タイトジャンクションに局在する2つの類似したPDZドメイン含有分子MUPP1とPatjの解析2007
- Author(s)
  足立誠
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19770168
[Presentation] Fluorescence localization-based expression cloning (FL-REX)法によるアドヘレンスジャンクション局在GTPase activating proteinの同定2007
- Author(s)
  小林由佳、松田美穂、増田小百合、足立誠、月田承一郎、古瀬幹夫
- Organizer
  第40回日本発生生物学会・第59回日本細胞生物学会合同大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17014044
[Presentation] Overlapping and distinct functions of two jomologous, PDZ domain-containing tight junction proteins, MUPP-1 and Patj.2006
- Author(s)
  Adachi, M, Hamazaki Y, Kobayashi Y, Itoh M, Sasaki H, Takai Y, Furuse M, Tsukita S.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology.
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-17014044

1. FURUSE Mikio (90281089)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. TSUKITA Sachiko (00188517)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. KUBO Akiharu (70335256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TAMURA Atsushi (00362525)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SASAKI Hiroyuki (60170693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. TSUKITA Shoichiro (50155347)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ODA Yukako (70452498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中尾和貴 (20217657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤雅彦 (70270486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 米村重信 (60192811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 永渕昭良 (80218023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Danev Radostin (50415931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中村駿 (80882779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 後藤慎平 (50747219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 近藤玄 (40243258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田中啓雄 (70795905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 柏原宏香 (20966692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 足澤悦子 (00446262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鈴木貴 (40114516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 矢野智樹 (20546121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 入江克雅 (20415087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 浅田秀基 (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 堂浦智裕 (00745226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 安田賢司 (40792081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Im Dohyun (50721883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 佐々木洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Adachi Makoto 足立 誠

ADACHI Makoto 足立 誠

Research Projects

Research Products

Co-Researchers

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of novel signaling mechanisms that regulates cell proliferation and divisionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of novel signaling pathways that regulate mammalian cell cytokinesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel signaling network that regulates cell growth and divisionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of novel components that localize to cell-cell adhesive structures in epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of cell-cell adhesion in cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

上皮細胞の極性形成に関与するaPKCの生理的基質の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Claudins in the epithelium/endothelium barrier dysfucrition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism for cell-cell adhesion in canceration and metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Multicellular modeling of ciliopathy by combining ips cells and microfluidic airway-on-a-chip technology2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis2014

Author(s)

Journal Title

DOI

Data Source

Adachi Makoto 足立誠

ADACHI Makoto 足立誠