WATASE Kei 渡瀬啓

Researcher Number	30376800
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2017: 東京医科歯科大学, 学内共同利用施設等, 准教授 2008 – 2015: Tokyo Medical and Dental University, 脳統合機能研究センター, 准教授 2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, COE抛点形成特任教員 2007: Tokyo Medical and Dental University, 21st Cent COE program, Lecturer/Associate Prof 2007: 東京医科歯科大学, 大学院・医歯学総合研究科, 特任講師 2005 – 2006: 東京医科歯科大学, 大学院医歯学総合研究科, COE拠点形成特任講師 2004: 東京医科歯科大学, 大学院・医歯学総合研究科, 講師
Review Section/Research Field	Principal Investigator Neurology / Biological Sciences / Basic / Social brain science Except Principal Investigator Neurology / Biological Sciences
Keywords	Principal Investigator 神経変性 / 脊髄小脳変性症6型 / リソソーム / ポリグルタミン病 / 治療 / RNA修復 / スプライス / 神経分子病態学 / 脳神経疾患 / 遺伝子 … More / 応用動物 / カルシウム / 小脳 / カルシウムチャネル / 小脳失調 / 失調 / プルキンエ細胞 / 神経炎症 / カルシウムチャンネル / ミクログリア / ポリグルタミン / 脊髄小脳変性症 / ノックインマウス / 遺伝子組換えマウス / 神経疾患 / パーキンソン病 / 遺伝子改変 / 神経変性疾患 / モデル動物 … More Except Principal Investigator 遺伝子 / 蛋白質 / Caチャンネル / 培養細胞 / P / SCA6 / Purkinje細胞 / 神経科学 / 脊髄小脳変性症 / α1A-Caチャンネル / 失調症 / ノックインマウス / 応用動物 / 内科 / 脳神経疾患 / 脊髄小脳失調症 / 封入体 / ポリグルタミン病 / 脊髓小脳変性症 / Q型カルシウムチャネル / 遺伝子治療 / 神経変性 / スプライス / 脊髄小脳変性症6型 / RNAi / 動物モデル / polyglutamine disease / Q type calcium channel / gene therapy / neurodegeneration / splicing Less

脊髄小脳変性症における脳内脂質恒常性異常の役割Principal Investigator
- Principal Investigator
  
  渡瀬啓
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
Establishing ES cell lines for neurological diseases using CRISPR/Cas9 systemsPrincipal Investigator
- Principal Investigator
  
  WATASE Kei
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
Cav2.1遺伝子異常による神経機能障害の解明Principal Investigator
- Principal Investigator
  
  渡瀬啓
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Lysosomal PolyQ accumulation as a target for treatment of SCA6Principal Investigator
- Principal Investigator
  
  Watase Kei
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic / Social brain science
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the pathogenesis of spinocerebellar ataxia type 6 using a novel knock-in mouse model that develops Purkinje cell degeneration.Principal Investigator
- Principal Investigator
  
  WATASE Kei
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
A basic research for identifying fundamental therapy for SCA6 and SCA31
- Principal Investigator
  
  MIZUSAWA Hidehiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
スプライシング機構をターゲットとした遺伝性神経変性疾患に対する治療戦略の確立Principal Investigator
- Principal Investigator
  
  渡瀬啓
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
Elucidation of pathomechanism and development of treatment of spinocerebellar ataxia type 6
- Principal Investigator
  
  MIZUSAWA Hidehiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
α1A‐Caチャンネル遺伝子の変異による脳細胞変性の分子病態
- Principal Investigator
  
  MIZUSAWA Hidehiro
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] ブレインサイエンスレビュー２０１５2015
- Author(s)
  渡瀬　啓
- Total Pages
  256
- Publisher
  クバプロ
- Data Source
  KAKENHI-PUBLICLY-25110712
[Book] ブレインサイエンスレビュー２０１５2015
- Author(s)
  渡瀬　啓
- Total Pages
  256
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-25282241
[Book] 論文ができてしまう!疾患モデルマウス表現型解析指南2011
- Author(s)
  渡瀬啓
- Total Pages
  6
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22590924
[Book] 脊髄小脳変性症6型(SCA6)モデルマウス脳・神経疾患-疾患モデルの作製と利用2011
- Author(s)
  渡瀬啓、水澤英洋
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-21249054
[Book] 脳・神経疾患-疾患モデルの作製と利用2011
- Author(s)
  渡瀬啓、水澤英洋
- Total Pages
  8
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-21249054
[Book] 脳・神経疾患-疾患モデルの作製と利用2011
- Author(s)
  渡瀬啓、水澤英洋
- Total Pages
  8
- Publisher
  エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-22590924
[Book] 脊髄小脳変性症6 型(SCA6)モデルマウス脳・神経疾患-疾患モデルの作製と利用2011
- Author(s)
  渡瀬啓、水澤英洋
- Publisher
  三品昌美
- Data Source
  KAKENHI-PROJECT-22590924
[Journal Article] Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.2016
- Author(s)
  Hebisawa, A., Aizawa, H., Cui, W., Fujita, Y., Hashimoto, K., Ajioka, I., Mizusawa, H., Yokota, T. and Watase K.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 25 Pages: 4507-4517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282241
[Journal Article] RpA1 ameliorates symptoms of mutant Ataxin-1 knock-in mice and enhances DNA damage repair.2016
- Author(s)
  Taniguchi, JB., Kondo, K., Fujita, K., Chen, X., Homma, H., Sudo, T., Mao, Y., Watase, K., Tanaka, T., Tagawa, K., Tamura, T., Muramatsu, SI., Okazawa, H.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 25 Pages: 4432-4447
- DOI
  10.1093/hmg/ddw272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-25282241, KAKENHI-PROJECT-26293213
[Journal Article] Loss of MyD88 alters neuroinflammatory response and attenuates cerebellar Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model.2015
- Author(s)
  Aikawa T, Mogushi K, Iijima-Tsutsui K, Ishikawa K, Sakurai　H, Tanaka H, Mizusawa H, Watase K
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 24（17） Pages: 4780-4791
- DOI
  10.1093/hmg/ddv202
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10035, KAKENHI-PROJECT-26860661, KAKENHI-PROJECT-25282241
[Journal Article] Spinocerebellar ataxia type 6: Lessons from faithful knock-in mouse models.n mouse models.2015
- Author(s)
  Kei Watase
- Journal Title
  
  Neurology and Clinical Neuroscience
  
  Volume: 3 Pages: 14-17
- DOI
  10.1111/ncn3.137
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25110712, KAKENHI-PROJECT-25282241
[Journal Article] Abnormalities in synaptic dynamics during development in a mouse model of late-onset neurodegenerative disease.2015
- Author(s)
  Hatanaka Y., Watase K., Wada K., Nagai Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 16102-16102
- DOI
  10.1038/srep16102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-25282241
[Journal Article] 脊髄小脳失調症6型(SCA6)2012
- Author(s)
  渡瀬啓, 水澤英洋
- Journal Title
  
  最新医学
  
  Volume: 67(5) Pages: 1082-1088
- Data Source
  KAKENHI-PROJECT-22590924
[Journal Article] Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA62012
- Author(s)
  Unno, T., Wakamori, M., Koike, M., Uchiyama, Y., Ishikawa, K., Kubota, H., Yoshida, T., Sasakawa, H., Peters, C., Mizusawa, H. and Watase K
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 109(43) Pages: 17693-17698
- DOI
  10.1073/pnas.1212786109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590924, KAKENHI-PROJECT-22659335, KAKENHI-PROJECT-23790238, KAKENHI-PROJECT-24591252, KAKENHI-PUBLICLY-23129503
[Journal Article] カルシウムチャネルのCAGリピート病-SCA6ノックインマウスの解析による病態解明2010
- Author(s)
  渡瀬啓, 海野敏紀
- Journal Title
  
  実験医学
  
  Volume: 28 Pages: 118-123
- Data Source
  KAKENHI-PROJECT-22590924
[Journal Article] Suppression of the novel ER proteinMaxer by mutant ataxin-1 in Bergmanglia contributes tonon-cell-autonomous toxicity2010
- Author(s)
  Shiwaku, H., Yoshimura, N., Tamura, T., Sone, M., Ogishima, S., Watase, K., Tagawa, K. and Okazawa H.
- Journal Title
  
  EMBO J
  
  Volume: 29(14) Pages: 2446-2460
- Data Source
  KAKENHI-PROJECT-21249054
[Journal Article] カルシウムチャネルのCAGリピート病-SCA6ノックインマウスの解析による病態解明2010
- Author(s)
  渡瀬啓、海野敏紀
- Journal Title
  
  実験医学
  
  Volume: 28 Pages: 118-123
- Data Source
  KAKENHI-PROJECT-21249054
[Journal Article] Spinocerebellar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Cav2.1 channels.2008
- Author(s)
  Watase K, et al.
- Journal Title
  
  Proceedings of the National Academy of Sciencesof the United States of America 105
  
  Pages: 11987-11992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659221
[Journal Article] Spinoncerebelar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Ca_v2.1 channels2008
- Author(s)
  Watase K, et. al.
- Journal Title
  
  Proceedings of the National Academy of Science of the USA (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Insulin-like growth factor pathway is altered in Spinocerebellar ataxia type 1 and type 7.2008
- Author(s)
  Gatchel JR, Watase K, Thaller C., Carson JP, Jafar-Nejad P, Shaw C, Zu T, Orr HT, Zoghbi HY.
- Journal Title
  
  Proceedings of the National Academy of Science of the USA 105
  
  Pages: 1291-1296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Spinocerebellar ataxia type 6 knock-in mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant Cav2.1 channels2008
- Author(s)
  Watase K, et. al.
- Journal Title
  
  Proc Natl Acad Sci USA (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Proieome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.2007
- Author(s)
  Qi ML, Tagawa K, Enokido Y, Yoshimura N, Wada, YI, Watase K. Ishiura S-i, Kanazawa I, Botas J, Saitoe M, Waiiker EE, Okazawa H
- Journal Title
  
  Nature Cell Biology 9
  
  Pages: 402-414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Lithium therapy improves neurological function and hippocampal dendritic arborization in a Spinocerebellar ataxia type I mouse model.2007
- Author(s)
  Watase K, et. al.
- Journal Title
  
  PLoS Medicine 5
  
  Pages: 182-182
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Lithium therapy improves neurological function and hippocampal dendritic arborization in a Spinocerebellar ataxia type I mouse model2007
- Author(s)
  Watase K, et. al.
- Journal Title
  
  PLoS Med 5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Lithium therapy improves neurological function and hippocampal dendritic arborization in a Spinocerebellar ataxia type 1 mouse model.2007
- Author(s)
  Watase K, Gatchel JR, Sun Y, Emamian E, Atkinson R, Richman R, Mizusawa H, Orr HT, Shaw C, Zoghbi HY.
- Journal Title
  
  PLoS Medicine 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] SCA6病態におけるミクログリア炎症性応答2016
- Author(s)
  渡瀬　啓
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] SCA6病態におけるミクログリア炎症性応答2016
- Author(s)
  渡瀬啓
- Organizer
  第57回日本神経学会総会
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] Genetical studies on knockin mice carrying a PARK17 mutation2015
- Author(s)
  Nobutaka Ishizu, Akira Hebisawa,Daishi Yui, Tomonori Aikawa, Hidehiro Mizusawa, Takanori Yokota, Kei Watase
- Organizer
  第５６回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26670438
[Presentation] Early neuroinflammatory response precedes Purkinje cell loss in the cerebellum of SCA6-knockin mouse models.2015
- Author(s)
  Watase K, Aikawa, T., Mogushi, K., Iijima-Tsutui, K., Ishikawa, K., Sakurai, M., Tanaka H., Mizusawa, H.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Barga, Italy
- Year and Date
  2015-05-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] M1-dominant microglial response precedes Purkinje cell loss in the cerebellum of SCA6-knockin mouse models.2015
- Author(s)
  Watase K, Aikawa, T., Mogushi, K., Iijima-Tsutui, K., Ishikawa, K., Sakurai, M., Tanaka H., Mizusawa, H.
- Organizer
  25th Biennial Meeting, International Society for Neurochemistry
- Place of Presentation
  Cairns, QLD, Australia
- Year and Date
  2015-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] Early neuroinflammatory response in SCA6 mouse models.2014
- Author(s)
  Aikawa, T., Mogushi, T., Iijima, K., Tanaka, H., Mizusawa, H. and Watase, K.
- Organizer
  第５５回日本神経学会学術大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] Lysosomal Contribution to the Purkinje cell degeneration in mouse models of spinocerebellar ataxia type 6.2013
- Author(s)
  Kei Watase
- Organizer
  ISN-ASN 2013
- Place of Presentation
  Cancun, Mexico
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] Cathepsin B欠損による脊髄小脳変性症6型モデルマウス小脳変性の促進2011
- Author(s)
  海野敏紀、水澤英洋、渡瀬啓
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] SCA6遺伝子エクソン47のスプライスパターンを再現する細胞系の確立2011
- Author(s)
  相川知徳、水澤英洋、渡瀬啓
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] ノックインマウスモデルを用いた脊髄小脳変性症の病態解明2011
- Author(s)
  渡瀬啓
- Organizer
  第28回東京医科歯科大学大学院医歯学総合研究科大学院セミナー
- Place of Presentation
  東京
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] A novel mouse model of spinocerebellar ataxia type 6 develops distinct Purkinje cell degeneration2011
- Author(s)
  Unno T, Mizusawa H, Watase K
- Organizer
  12^<th> International Congress of Human Genetics/61^<st> Annunal Meeting of the American Society of Human Genetics.
- Place of Presentation
  Montreal, Quebec, Canada
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] ノックインマウスモデルを用いた脊髄小脳変性症の病態解明2011
- Author(s)
  渡瀬啓
- Organizer
  第28回東京医科歯科大学大学院医歯学総合研究科大学院セミナー
- Place of Presentation
  東京
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] A novel mouse model of spinocerebellar ataxia type 6 develops distinct Purkinje cell degeneration2011
- Author(s)
  Unno T, Mizusawa H, Watase K
- Organizer
  12^<th> International Congress of Human Genetics/61^<st> Annunal Meeting of the American Society of Human Genetics
- Place of Presentation
  Montreal, Quebec, Canada
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] SCA6遺伝子エクソン47のスプライスパターンを再現する細胞系の確立2011
- Author(s)
  相川知徳、水澤英洋、渡瀬啓
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] A novel mouse model of spinocerebellar ataxia type 6 develops distinct Purkinje cell degeneration2011
- Author(s)
  Unno T, Mizusawa H, Watase K
- Organizer
  12^<th> International Congress of Human Genetics / 61^<st> Annunal Meeting of the American Society of Human Genetics
- Place of Presentation
  Montreal, Quebec, Canada
- Year and Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] 脊髄小脳変性症6型モデルマウスの病理学的解析2010
- Author(s)
  海野敏紀, 渡瀬啓, 水澤英洋
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] シンポジウム:神経難病の克服 -単一遺伝子病からのアプローチーSCA6-原因の同定から治療法の開発へ-2010
- Author(s)
  渡瀬啓, 石川欽也, 水澤英洋
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] 脊髄小脳変性症6型の治療法開発に向けたマウスモデルの開発2010
- Author(s)
  渡瀬啓
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] SCA6原因の同定から治療法の開発へ2010
- Author(s)
  渡瀬啓,石川欽也,水澤英洋
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] シンポジウム:神経難病の克服-単一遺伝子病からのアプローチ-SCA6-原因の同定から治療法の開発2010
- Author(s)
  渡瀬啓, 石川欽也, 水澤英洋
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22590924
[Presentation] SCA6ノックインマウス表現型の経時的検討2009
- Author(s)
  渡瀬啓, Barrett CF,宮崎太輔、海野敏紀、石川欽也、笠井沙由美、渡辺雅彦、水澤英洋、Tsien RW, Zoghbi HY
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21249054
[Presentation] Spinocerebellar ataxia type 6 knock-in mice develop motor impairment and reveal novelinsight about SCA6 pathogenesis.2008
- Author(s)
  Watase K, et al.
- Organizer
  38^<th> Annual Meeting of the Society for Neuroscience.
- Place of Presentation
  Washington DC (米国)
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19659221
[Presentation] スプライシング機構をターゲットとした脊髄小脳変性症6型の治療戦略の確立2008
- Author(s)
  赤芝洋紀、松木則夫、水澤英洋、渡瀬啓
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19659221
[Presentation] Expansion of CAG repeats in α1A Ca^<2+> channel gene leads to altered splicing patterns at the boundaries of exon46/exon47.2007
- Author(s)
  Akashiba H, Matsuki N, Mizusawa H, Watase K.
- Organizer
  37th Annual Meeting of the Society for Neuroscience.
- Place of Presentation
  San Diego, CA(米国)
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Lithium improves neurological dysfunction in a knock-in mouse model of Spinocerebellar ataxia type l.2007
- Author(s)
  Watase K, et. al.
- Organizer
  Keystone Symposium: Molecular Mechanisms of Neurodegeneration
- Place of Presentation
  Taos
- Year and Date
  2007-01-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Lithium improves neurological dysfunction in a knock-in mouse model of Spinocerebellar ataxia type 12007
- Author(s)
  Watase K, et. al.
- Organizer
  Keystone Symposium : Molecular Mechanisms of Neurodegeneration
- Place of Presentation
  Taos
- Year and Date
  2007-01-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Expansion of CAG repeats in α1A Ca^<2+> channel gene leads to altered splicing patterns at the boundaries of exon46/exon47.2007
- Author(s)
  Akashiba H, Matsuki N, Mizusawa H, Watase K.
- Organizer
  37th Annual Meeting of the Society for Neuroscience.
- Place of Presentation
  San Diego, CA(米国)
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19659221
[Presentation] Therapeutic effects of lithium in a knock-in mouse model of Spinocerebellar ataxia type 12006
- Author(s)
  Watase K, et. al.
- Organizer
  28th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Yokohama
- Year and Date
  2006-07-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Knockin mouse models as an approach to spinocerebellar ataxias.2005
- Author(s)
  Watase K.
- Organizer
  1st Workshop on Polyglutamine Disease and Related Disorders -New Perspectives
- Place of Presentation
  東京
- Year and Date
  2005-09-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Knockin mouse models as an approach to spinocerebellar ataxias2005
- Author(s)
  Watase K.
- Organizer
  1st Workshop on Polyglutamine Disease and Related Disorders-New Perspectives
- Place of Presentation
  Tokyo
- Year and Date
  2005-09-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Therapeutic effects of lithium in a knock-in mouse model of Spinocerebellar ataxia type 1.2005
- Author(s)
  Watase K, et. al.
- Organizer
  28th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  横浜
- Year and Date
  2005-07-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Early neuroinflammatory response precedes Purkinje cell loss in the cerebellum of SCA6-knockin mouse models.
- Author(s)
  Kei Watase
- Organizer
  Gordon Research Conference: CAG Triplet Repeat Disorders
- Place of Presentation
  Lucca (Barga) Italy
- Year and Date
  2015-05-31 – 2015-06-05
- Data Source
  KAKENHI-PROJECT-25282241
[Presentation] unctional role of the cytoplasmic terminal tail of Cav2.1 channel.
- Author(s)
  Aikawa, T., Miyazaki, T., Mikuni, T., Shigemoto, R., Wakamori, M., Kano, M., Watanabe, M., Mizusawa, H. and Watase, K.
- Organizer
  International Symposium "New Frontier of Molecular Neuropathology 2014".
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PUBLICLY-25110712

1. MIZUSAWA Hidehiro (30144091)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
2. ISHIKAWA Kinya (30313240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. YOKOTA Takanori (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 藤ヶ崎浩人 (40345286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 常深泰司 (50401344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 融衆太 (50376711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MOGUSHI Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MURAMATSU S Hinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 相川知徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 若森実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岡澤均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 永井義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATASE Kei 渡瀬 啓

Research Projects

Research Products

Co-Researchers

脊髄小脳変性症における脳内脂質恒常性異常の役割Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Establishing ES cell lines for neurological diseases using CRISPR/Cas9 systemsPrincipal Investigator

Principal Investigator

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Cav2.1遺伝子異常による神経機能障害の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lysosomal PolyQ accumulation as a target for treatment of SCA6Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Elucidation of the pathogenesis of spinocerebellar ataxia type 6 using a novel knock-in mouse model that develops Purkinje cell degeneration.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

A basic research for identifying fundamental therapy for SCA6 and SCA31

Principal Investigator

Project Period (FY)

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Research Institution

スプライシング機構をターゲットとした遺伝性神経変性疾患に対する治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathomechanism and development of treatment of spinocerebellar ataxia type 6

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

α1A‐Caチャンネル遺伝子の変異による脳細胞変性の分子病態

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] ブレインサイエンスレビュー２０１５2015

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[Book] ブレインサイエンスレビュー２０１５2015

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[Book] 論文ができてしまう!疾患モデルマウス表現型解析指南2011

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[Book] 脊髄小脳変性症6型(SCA6)モデルマウス脳・神経疾患-疾患モデルの作製と利用2011

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[Book] 脳・神経疾患-疾患モデルの作製と利用2011

Author(s)

Total Pages

WATASE Kei 渡瀬啓