Tsunemi Taiji 常深泰司

… Alternative Names

常深泰司ツネミタイジ

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Researcher Number	50401344
Other IDs
Affiliation (Current)	2022: 順天堂大学, 大学院医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 順天堂大学, 医学(系)研究科(研究院), 准教授 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 助手 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator パーキンソン病 / アルファシヌクレイン / Kufor-Rakeb症候群 / エキソソーム / ATP13A2 / αシヌクレイン / PARK9 / 遺伝学 / 神経科学 / 脳神経疾患 … More / 細胞・組織 / トランスレーショナルリサーチ / iPS細胞 / ドーパミン細胞 / ライソゾーム / FYVEタンパク質 / ALIX / 脳・神経 / レヴィ小体 / アストロサイト / Lewy小体 / ライブイメージング / 超解像顕微鏡 / 血管脳関門 … More Except Principal Investigator P / SCA6 / ポリグルタミン病 / 脊髓小脳変性症 / Q型カルシウムチャネル / 遺伝子治療 / 神経変性 / スプライス / 脊髄小脳変性症6型 / Caチャンネル / RNAi / 動物モデル / 培養細胞 / polyglutamine disease / Q type calcium channel / gene therapy / neurodegeneration / splicing Less

エキソソームによるαシヌクレインの末梢組織から中枢神経への拡散機序の解明Principal Investigator
- Principal Investigator
  
  常深泰司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
Exploration of the process of exosome generation which reduce alpha synuclein accumulation and development of novel PD therapyPrincipal Investigator
- Principal Investigator
  
  Tsunemi Taiji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Juntendo University
The exploration of pathophysiology and therapeutic development of PD by targeting exosomesPrincipal Investigator
- Principal Investigator
  
  Tsunemi Taiji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Elucidation of pathomechanism and development of treatment of spinocerebellar ataxia type 6
- Principal Investigator
  
  MIZUSAWA Hidehiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] ブレインサイエンスレヴュー20182018
- Author(s)
  常深泰司
- Publisher
  ブレインサイエンス振興財団
- Data Source
  KAKENHI-PROJECT-16H07185
[Book] イオンチャネル最前線update(倉智嘉久編)2005
- Author(s)
  常深泰司, 水澤英洋.
- Total Pages
  5
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Shared Metabolic Profile of Caffeine in Parkinsonian Disorders.2020
- Author(s)
  Takeshige‐Amano Haruka、Saiki Shinji、Fujimaki Motoki、Ueno Shin‐Ichi、Li Yuanzhe、Hatano Taku、Ishikawa Kei‐Ichi、Oji Yutaka、Mori Akio、Okuzumi Ayami、Tsunemi Taiji、Daida Kensuke、Ishiguro Yuta、Imamichi Yoko、Nanmo Hisayoshi、Nojiri Shuko、Funayama Manabu、Hattori Nobutaka
- Journal Title
  
  Mov Disord
  
  Volume: 35 Pages: 1438-1447
- DOI
  10.1002/mds.28068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K07510
[Journal Article] Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation2020
- Author(s)
  Tsunemi Taiji、Ishiguro Yuta、Yoroisaka Asako、Valdez Clarissa、Miyamoto Kengo、Ishikawa Keiichi、Saiki Shinji、Akamatsu Wado、Hattori Nobutaka、Krainc Dimitri
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 40 Pages: 8618-8628
- DOI
  10.1523/jneurosci.0954-20.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K07510
[Journal Article] Variants in saposin D domain of prosaposin gene linked to Parkinson's disease2020
- Author(s)
  Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, et al.
- Journal Title
  
  Brain.
  
  Volume: 143 Pages: 1190-1205
- DOI
  10.1093/brain/awaa064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-19K16928, KAKENHI-PROJECT-19K17019, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18K15463, KAKENHI-PROJECT-19K08288, KAKENHI-PROJECT-18K07510, KAKENHI-PROJECT-19K23782
[Journal Article] Bilateral thigh compartment syndromes from extended sitting with forward bending2019
- Author(s)
  Shimada T, Tsunemi T, Hattori A, Nakazato-Taniguchi T, Yasuhara H, Ogaki K, Hattori N
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 5868 Pages: 35-37
- DOI
  10.1016/j.jocn.2019.03.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07510, KAKENHI-PROJECT-19K17047, KAKENHI-PROJECT-17K14966
[Journal Article] パーキンソン症状をきたす脊髄小脳変性症2018
- Author(s)
  石黒雄太、常深泰司、服部信孝
- Journal Title
  
  難病と在宅ケア
  
  Volume: 23 Pages: 17-20
- Data Source
  KAKENHI-PROJECT-16H07185
[Journal Article] 総論　特集“脊髄小脳変性症の最近の治療と研究”2018
- Author(s)
  常深泰司、服部信孝
- Journal Title
  
  難病と在宅ケア
  
  Volume: 23 Pages: 5-8
- NAID
  40021455260
- Data Source
  KAKENHI-PROJECT-16H07185
[Journal Article] 日本におけるパーキンソン病治療の変遷と展望　特集　パーキンソン病2017
- Author(s)
  常深泰司、服部信孝
- Journal Title
  
  日本臨床
  
  Volume: 75 Pages: 14-20
- Data Source
  KAKENHI-PROJECT-16H07185
[Journal Article] 日本におけるパーキンソン病治療の変遷と展望2017
- Author(s)
  常深泰司、服部信孝
- Journal Title
  
  日本臨床
  
  Volume: 75 Pages: 14-20
- Data Source
  KAKENHI-PROJECT-16H07185
[Journal Article] Direct and accurate measurement of CAG repeat configuration in the ataxin-l(ATXN-I)gene by "dual-fluorescence labeled PCR-restriction fragment length analysis"2008
- Author(s)
  Lin JX, Ishikawa K, Sakamoto M, Tsunemi T, Ishiguro T, Amino T, Toru S, Kondo 1, Mizusawa H.
- Journal Title
  
  Journal of Human Genetics 53
  
  Pages: 287-295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia.2007
- Author(s)
  Amino T, Ishikawa K, Toru S, Ishiguro T, Sato N, Tsunemi T, Murata M, Kobayashi K, Inazawa J, Toda T, Mizusawa H.
- Journal Title
  
  Journal of Human Genetics 52
  
  Pages: 643-649
- NAID
  10019812756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17209031
[Journal Article] An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5'untranslated region of the gene encoding a protein with spectrin repeat and rho guanine-nucleotide exchange-factor domains.2005
- Author(s)
  Ishikawa K, Toru S, Tsunemi T, Li M, Kobayashi K, Yokota T, Amino T, Mizusawa H et al.
- Journal Title
  
  Am.J.Hum.Genet 77
  
  Pages: 280-296
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] ATP13A2/PARK9 protects brains from α-synuclein propagation2020
- Author(s)
  T. Tsunemi, Y. Ishiguro, A. Yoroisaka, A. Okuzumi, N. Nukina and N. Hattori
- Organizer
  第61回日本精神神経学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] The a-syn filaments in exosomes are useful biomarker for Parkinson’s disease2020
- Author(s)
  Yuta Ishiguro, Taiji Tsunemi, Asako Yoroisaka, Nobutaka Hattori
- Organizer
  第61回日本精神神経学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] The exosomal a-syn filaments can be a novel biomarker of Parkinson’s disease2020
- Author(s)
  Yuta Ishiguro, Taiji Tsunemi, Asako Yoroisaka, Nobutaka Hattori
- Organizer
  International Congress, Movement Disorder Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] Protective role of astrocytes on α-synuclein accumulation and propagation2020
- Author(s)
  Taiji Tsunemi, Yuta Ishiguro, Asako Yoroisaka, Dimitri Krainc, Nobutaka Hattori
- Organizer
  International Congress, Movement Disorder Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] The effect of ATP13A2/PARK9 levels on a-synuclein spreading in mice brains2019
- Author(s)
  T. Tsunemi, Y. Ishiguro, A. Okuzumi, A. Yoroisaka, N. Nobuyuki and N. Hattori
- Organizer
  International Congress of Parkinson's Disease and Movement Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] Spreading of α-synuclein in Atp13a2-deficient mice2019
- Author(s)
  常深泰司、石黒雄太、鎧坂朝子、奥住文香、貫名信行、服部信孝
- Organizer
  第13回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] FTD-3-asscociated CHMP2B mutations lead to impaired exosomal secretion2019
- Author(s)
  Taiji Tsunemi, Yuta Ishiguro, Asako Yoroisaka, Wado Akamatsu2 Nobutaka Hattori
- Organizer
  60th Annual Meeting of the Japanese Society of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] The increased α-syn expression inhibits exosome secretion2018
- Author(s)
  Yuta Ishiguro、Taiji Tsunemi, Asako Yoroisaka, Wado Akamatsu, Dimitri Krainc, Nobutaka Hattori
- Organizer
  International Congress of Parkinson's Disease and Movement Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] Exosomal alpha synuclein secretion is beneficial for cellular models of Kufor-Rakeb syndrome2018
- Author(s)
  Taiji Tsunemi, Yuta Ishiguro, Wado Akamatsu, Dimitri Krainc, Nobutaka Hattori
- Organizer
  International Congress of Parkinson's Disease and Movement Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07510
[Presentation] ATP13A2/PARK9 deficiency leads to impaired lysosomal exocytosis2017
- Author(s)
  Taiji Tsunemi, Asako Yoroizaka, Wado Akamatsu, Hattori Nobutaka
- Organizer
  老人性疾患病態・治療研究センター / ゲノム・再生医療センター合同研究発表会
- Place of Presentation
  東京　順天堂大学
- Data Source
  KAKENHI-PROJECT-16H07185
[Presentation] ATP13A2/PARK9 regulates intracellular a-synuclein levels through exocytotic pathways2017
- Author(s)
  Taiji Tsunemi, Yuta Ishiguro, Katarina Trajkovic, Zong Xie, Tamara Perez-Rosello, Joseph Mazzulli, Wado Akamatsu, Haoxing Xu, Jim Surmeier, Dimitri Krainc, Nobutaka Hattori
- Organizer
  WCN2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07185
[Presentation] Kufor-Rakeb症候群におけるエンドライソゾーム機能障害2016
- Author(s)
  常深泰司
- Organizer
  第35回日本認知症学会
- Place of Presentation
  東京フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16H07185
[Presentation] Kufor-Rakeb症候群の病態から考えるパーキンソン病の発症機序2016
- Author(s)
  常深泰司
- Organizer
  御茶ノ水神経内科懇話会
- Place of Presentation
  東京ホテルモントレ半蔵門
- Invited
- Data Source
  KAKENHI-PROJECT-16H07185
[Presentation] エキソソームをターゲットとしたパーキンソン病の病態解明と新規治療法の開発2016
- Author(s)
  Taiji Tsunemi, Clarissa Valdez, Katarina Trajkovic, Asako Yoroizaka, Kana Hamada, Sohee Jeon, Malini Krishna Vangipurum Suresh, Nobutaka Hattori, Dimitri Krainc
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07185
[Presentation] 16番染色体長腕連鎖型優性遺伝性脊髄小脳変性症の原因遺伝子座の解析.2007
- Author(s)
  網野猛志, 佐藤望, 石黒太郎, 常深泰司, 融衆太, 戸田達史, 水澤英洋, 石川欽也.
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] The effect of 3, 4-diaminopyridine on the postural imbalance and downbeat nystagmus in patients with ataxia.2007
- Author(s)
  Tsunemi T, Ishikawa K, Mizusawa H.
- Organizer
  59th Annual Meeting of the American Academy of Neurology
- Place of Presentation
  Boston,MA(米国)
- Year and Date
  2007-05-01
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] The effect of 3,4-diaminopyridine on the postural imbalance and downbeatnystagmus in patients with ataxia.2007
- Author(s)
  Tsunemi T, et. al.
- Organizer
  59th Annual Meeting of Am Acad of Neurology
- Place of Presentation
  Boston
- Year and Date
  2007-05-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] The effect of 3,4-diaminopyridine on the postural imbalance and downbeat nystagmus in patients with ataxia2007
- Author(s)
  Tsunemi T, et. al.
- Organizer
  59th Annual Meeting of the Am Acad of Neurology
- Place of Presentation
  Boston
- Year and Date
  2007-05-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Analysis of gene dosage of alpha-synuclein gene in multisystem atrophy2006
- Author(s)
  Tsunemi T, et. al.
- Organizer
  56th Annual Meeting of Am Soc of Human Genetics
- Place of Presentation
  New Orleans
- Year and Date
  2006-10-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Analysis of gene dosage of alpha-synuclein gene in multisystem atrophy.2006
- Author(s)
  Tsunemi T, et. al.
- Organizer
  Am Soc of Human Genetics 56th Ann Meeting
- Place of Presentation
  New Orleans
- Year and Date
  2006-10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] 脊髄小脳失調症6型におけるプルキンエ細胞特異的スプライス異常の検索.2006
- Author(s)
  常深泰司, 他
- Organizer
  第47回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2006-05-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Cell-specific alternative splicing in Spinocerebellar ataxia Type 62006
- Author(s)
  Tsunemi T, et. al.
- Organizer
  58th Annual Meeting of the Am Acad of Neurology
- Place of Presentation
  San Diego
- Year and Date
  2006-04-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] Cell-specific alternative splicingin spinocerebellar ataxia type 6.2006
- Author(s)
  Tsunemi T, et. al.
- Organizer
  58th Annual Meeting of Am Acad of Neurology
- Place of Presentation
  San Diego
- Year and Date
  2006-04-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031
[Presentation] 第16番染色体長腕連鎖型優性遺伝性小脳皮質萎縮症(16q-ADCCA)の原因遺伝子検索.2005
- Author(s)
  常深泰司, 他
- Organizer
  第46回日本神経学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2005-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209031

1. 赤松和土 (60338184)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. MIZUSAWA Hidehiro (30144091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. YOKOTA Takanori (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. WATASE Kei (30376800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIKAWA Kinya (30313240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 融衆太 (50376711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 竹下幸男 (70749829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. HATANO Taku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. MATSUDA Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石川景一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 大垣光太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 服部信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 佐藤栄人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 王子悠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 野田幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsunemi Taiji 常深 泰司

常深 泰司 ツネミ タイジ

Research Projects

Research Products

Co-Researchers

エキソソームによるαシヌクレインの末梢組織から中枢神経への拡散機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of the process of exosome generation which reduce alpha synuclein accumulation and development of novel PD therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The exploration of pathophysiology and therapeutic development of PD by targeting exosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of pathomechanism and development of treatment of spinocerebellar ataxia type 6

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ブレインサイエンスレヴュー20182018

Author(s)

Publisher

Data Source

[Book] イオンチャネル最前線update(倉智嘉久 編)2005

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Shared Metabolic Profile of Caffeine in Parkinsonian Disorders.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Variants in saposin D domain of prosaposin gene linked to Parkinson's disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bilateral thigh compartment syndromes from extended sitting with forward bending2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] パーキンソン症状をきたす脊髄小脳変性症2018

Author(s)

Journal Title

Data Source

[Journal Article] 総論 特集“脊髄小脳変性症の最近の治療と研究”2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 日本におけるパーキンソン病治療の変遷と展望 特集 パーキンソン病2017

Author(s)

Journal Title

Data Source

[Journal Article] 日本におけるパーキンソン病治療の変遷と展望2017

Author(s)

Journal Title

Data Source

[Journal Article] Direct and accurate measurement of CAG repeat configuration in the ataxin-l(ATXN-I)gene by "dual-fluorescence labeled PCR-restriction fragment length analysis"2008

Author(s)

Journal Title

Data Source

Tsunemi Taiji 常深泰司

常深泰司ツネミタイジ

[Book] イオンチャネル最前線update(倉智嘉久編)2005

[Journal Article] 総論　特集“脊髄小脳変性症の最近の治療と研究”2018

[Journal Article] 日本におけるパーキンソン病治療の変遷と展望　特集　パーキンソン病2017