UCHINO Shigeo 内野茂夫

Researcher Number	30392434
Affiliation *help	2016 – 2018 : 帝京大学, 理工学部, 教授 2013 – 2014 : 帝京大学, 理工学部, 教授 2010 : 独立行政法人国立精神・神経医療研究センター, 神経研究所・代謝研究部, 室長 2010 : National Center of Neurology and Psychiatry, 神経研究所代謝研究部, 室長 2009 : National Center of Neurology and Psychiatry, 代謝研究部, 室長 … More
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 46030:Function of nervous system-related Except Principal Investigator Biological Sciences
Keywords	Principal Investigator SHANK3 / FISH / 遺伝子診断 / Shank3 / 22q13.3欠失症候群 / ゲノム / 広汎性発達障害 / シナプス / エピジェネティクス / 小児自閉症 … More Except Principal Investigator ニューロン / ミクログリア / 神経科学 / 可視化 / ATP受容体 / スパイン / マーモセット / P2Y12受容体 / Iba1 / EGFP / カルシウム / マクロファージ / 遊走能 / 膜ラッフル / ATP / 脳発達 / トランスジェニックマウス / NMDA受容体 / ケモタキシス / グルタミン酸 / P2X4受容体 Less

自閉スペクトラム症病態モデルマウスの社会性異常行動の起因となる神経回路の特定Principal InvestigatorOngoing
- Principal Investigator
  
  内野茂夫
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Teikyo University
ニューロン・ミクログリア相関による機能的神経回路形成の分子基盤の解明Ongoing
- Principal Investigator
  
  高坂新一
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
Analysis of neuropathogenesis for autism spectrum disorders caused by mutation of SHANK3 gene.Principal Investigator
- Principal Investigator
  
  UCHINO Shigeo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Center of Neurology and Psychiatry
Pathological and epidemiological analysis of autism spectrum disorder based on synaptic moleculesPrincipal Investigator
- Principal Investigator
  
  UCHINO Shigeo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  National Center of Neurology and Psychiatry
ATPを介したニューロン・ミクログリア相互作用の分子基盤
- Principal Investigator
  
  高坂新一
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry

All 2017 2014 2013 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Allograft inflammatory factor 1 is a regulator of transcytosis in M cells2017
- Author(s)
  Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H.
- Journal Title
  
  Nat Commun.
  
  Volume : 8 Pages : 14509-14509
- DOI
  10.1038/ncomms14509
- Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23229004, KAKENHI-PLANNED-25117009, KAKENHI-PROJECT-16K08836
[Journal Article] Identification of two novel Shank3 transcripts in the developing mouse neocortex.2014
- Author(s)
  Waga C, Asano H, Sanagi T, Suzuki E, Nakamura Y, Tsuchiya A, Itoh M, Goto Y, Kohsaka S and Uchino S.
- Journal Title
  
  J. Neurochem
  
  Volume : 128
- DOI
  10.1111/jnc.12505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25117009
[Journal Article] Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex.2013
- Author(s)
  Yuko Gonda, William D. Andrews, Hidenori Tabata, Takashi Namba, John G. Parnavelas, Kazunori Nakajima, Shinichi Kohsaka, Carina Hanashima and Shigeo Uchino
- Journal Title
  
  Cerebral Cortex
  
  Volume : 23(6) Pages : 1495-1508
- DOI
  10.1093/cercor/bhs141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22240041, KAKENHI-PROJECT-24500394, KAKENHI-PLANNED-25117009, KAKENHI-PUBLICLY-25123725, KAKENHI-PLANNED-22111004, KAKENHI-PUBLICLY-23123522, KAKENHI-ORGANIZER-22111001
[Journal Article] Novel variants of the SHANKS gene in Japanese autistic patients with severe delayed speech development.2011
- Author(s)
  Waga C, Okamoto N, Ondo Y, Goto Y, Kohsaka S, Uchino S
- Journal Title
  
  Psychiatr.Genet.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] PEDF up-regulation induced by memantine, an NMDA receptor antagonist, is involved in the increased proliferation hippocampal progenitor cells.2010
- Author(s)
  Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Hirasawa E, Mochizuki H, Kohsaka S, Uchino S
- Journal Title
  
  Neuroscience 167
  
  Pages : 372-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] Inhibition of NMDA receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex.2010
- Author(s)
  Uchino S, Hirasawa T, Tabata H, Gonda Y, Waga C, Ondo Y, Naka j ima K, Kohsaka S
- Journal Title
  
  Neuroscience 169
  
  Pages : 609-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] Inhibition of N-methyl-D-aspartate receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex.2010
- Author(s)
  内野茂夫, 他
- Journal Title
  
  Neuroscience
  
  Volume : 169 Pages : 609-618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus.2009
- Author(s)
  OMaekawa T, Namba T, Suzuki E, Yuasa S, Kohsaka S, Uchino S
- Journal Title
  
  Neurosci.Res. 63
  
  Pages : 259-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] The Alzheimer' s disease drug memantine increases the number of radial glia-like progenitor cells in the adult hippocampus.2009
- Author(s)
  Namba T, Maekawa T, Yuasa S, Kohsaka S, Uchino S
- Journal Title
  
  GLIA 57
  
  Pages : 1082-1090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591239
[Journal Article] Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain containing synaptic molecule Shark3 with GluR1 α-amino3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.2006
- Author(s)
  内野茂夫
- Journal Title
  
  Journal of Neurochemistry 97・4
  
  Pages : 1203-1214
- Data Source
  KAKENHI-PROJECT-18591176
[Journal Article] Direct interaction of PDZ domain-containing synaptic molecule Shank3 with GluR1 AMPA receptor.2006
- Author(s)
  Shigeo Uchino
- Journal Title
  
  Journal of Neurochemistry Vol.97
  
  Pages : 1203-1214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591176
[Journal Article] Direct interaction of PDZ domain-containing synaptic molecule Shank3 with GluR1 AMPA receptor.2006
- Author(s)
  内野茂夫
- Journal Title
  
  Journal of Neurochemistry 97
  
  Pages : 1203-1214
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591176
[Journal Article] Visualization of microglia in living tissues by using Iba1-EGFP transgenic mice.2005
- Author(s)
  Hirasawa, T., Ohsawa, K., Imai, Y., Ondo, Y., Akazawa, C., Uchino, S., Kohsaka, S.
- Journal Title
  
  J.Neurosci.Res. 81
  
  Pages : 357-362
- Data Source
  KAKENHI-PROJECT-15082213
[Journal Article] Visualization of microglia in living tissues by using Iba1-EGFP transgenic mice.2005
- Author(s)
  Hirasawa, T., Ohsawa, K., Imai, Y., Ondo, Y., Uchino, S.
- Journal Title
  
  J.Neurosci.Res. (in press)
- Data Source
  KAKENHI-PROJECT-15082213
[Presentation] マーモセット発達過程におけるシナプス形成へのミクログリアの関与2014
- Author(s)
  佐栁友規、佐々木哲也、境和久、内野茂夫、髙坂新一、一戸紀孝
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PLANNED-25117009
[Presentation] マウス脳発達過程における自閉症関連遺伝子SHANK3のメチル化動態解析2010
- Author(s)
  和賀央子、浅野弘嗣、加藤怜子、伊藤雅之、後藤雄一、内野茂夫、高坂新一
- Organizer
  第33回日本神経科学会・第53回日本神経化学会・第20回日本神経回路学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] 自閉症関連遺伝子5朋N第3のマウス脳発達過程におけるメチル化動態解析およびその分子基盤に関する研究2010
- Author(s)
  和賀央子、浅野弘嗣、加藤怜子、伊藤雅之、後藤雄一、内野茂夫、高坂新一
- Organizer
  第40回日本神経精神薬理学会・第20回臨床精神神経薬理学会
- Place of Presentation
  仙台
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] Novel mutations in the SHANKS gene in autistic patients with severe delayed speech development.2009
- Author(s)
  Uchino S, Waga C, Okamoto N, Goto Y, Kohsaka S
- Organizer
  The 22nd Biennial Meeting of the International Society for Neurochemistry (ISN)/Asian Pacific Society for Neurochemistry (APSN) Joint Meeting.
- Place of Presentation
  Busan, Korea
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] Novel mutations in the SHNAK3 gene in autistic patients with severe delayed speech development2009
- Author(s)
  内野茂夫
- Organizer
  The 22^<nd> Biennial Meeting of the International Society for Neurochemistry/Asia Pacific Society for Neurochemistry Joint Meeting
- Place of Presentation
  BEXCO Busan, Korea
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] 自閉症患者におけるシナプス機能分子SHANK3の遺伝子解析2008
- Author(s)
  内野茂夫
- Organizer
  日本神経化学会シンポジウム
- Place of Presentation
  富山
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] SHANK3異常症例の臨床的検討2008
- Author(s)
  岡本伸彦、内野茂夫
- Organizer
  第50回日本小児神経学会
- Place of Presentation
  東京
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] 自閉症患者におけるシナプス機能分子SHANK3の遺伝子解析2008
- Author(s)
  内野茂夫、和賀央子、岡本伸彦、高坂新一
- Organizer
  第51回日本神経化学会、シンポジウム「発達障害の神経化学」
- Place of Presentation
  富山
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-20591239
[Presentation] リアルタイムイメージングを用いた培養海馬組織切片におけるミクログリア活性化機構の解析2007
- Author(s)
  岡村敏行、片山貴博、松田知己、永井健治、木村宏、内野茂夫、高坂新一、南雅文
- Organizer
  第30回擾本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-15082213

1. GONDA Yuko (60424181)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
2. WAGA Chikako (80462795)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
3. OKAMOTO Nobuhiko (30416242)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
4. 高坂新一 (50112686)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
5. ITOH Masayuki (50243407)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
6. NAMBA Takashi (70462794)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
7. KUBOTA Takeo (70293511)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 大澤圭子 (40392435)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
9. 入野康宏 (10415565)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 橋本学 (20415566)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 奥野孝枝 (10402083)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
12. 一戸紀孝 (00250598)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
13. 神鳥和代

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. TABATA Hidenori

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. NAKAJIMA Kazunori

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 清野宏

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 花嶋かりな

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

UCHINO Shigeo 内野 茂夫

Research Projects

Research Products

Co-Researchers

自閉スペクトラム症病態モデルマウスの社会性異常行動の起因となる神経回路の特定Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ニューロン・ミクログリア相関による機能的神経回路形成の分子基盤の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of neuropathogenesis for autism spectrum disorders caused by mutation of SHANK3 gene.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological and epidemiological analysis of autism spectrum disorder based on synaptic moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ATPを介したニューロン・ミクログリア相互作用の分子基盤

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Allograft inflammatory factor 1 is a regulator of transcytosis in M cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of two novel Shank3 transcripts in the developing mouse neocortex.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel variants of the SHANKS gene in Japanese autistic patients with severe delayed speech development.2011

Author(s)

Journal Title

Data Source

[Journal Article] PEDF up-regulation induced by memantine, an NMDA receptor antagonist, is involved in the increased proliferation hippocampal progenitor cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of NMDA receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex.2010

Author(s)

Journal Title

Data Source

[Journal Article] Inhibition of N-methyl-D-aspartate receptor activity resulted in aberrant neuronal migration caused by delayed morphological development in the mouse neocortex.2010

Author(s)

Journal Title

Data Source

[Journal Article] NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus.2009

Author(s)

Journal Title

Data Source

[Journal Article] The Alzheimer' s disease drug memantine increases the number of radial glia-like progenitor cells in the adult hippocampus.2009

Author(s)

Journal Title

Data Source

[Journal Article] Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain containing synaptic molecule Shark3 with GluR1 α-amino3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.2006

Author(s)

Journal Title

Data Source

[Journal Article] Direct interaction of PDZ domain-containing synaptic molecule Shank3 with GluR1 AMPA receptor.2006

Author(s)

Journal Title

UCHINO Shigeo 内野茂夫