Sasahira Naoki 笹平直樹

… Alternative Names

笹平直樹ササヒラナオキ

SASAHIRA Naoki 笹平直樹

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Researcher Number	30401102
Affiliation (Current)	2025: 公益財団法人がん研究会, 有明病院肝・胆・膵内科, 部長
Affiliation (based on the past Project Information) *help	2021 – 2024: 公益財団法人がん研究会, 有明病院肝・胆・膵内科, 部長 2017 – 2019: 公益財団法人がん研究会, 有明病院肝・胆・膵内科, 部長 2015 – 2016: 公益財団法人がん研究会, その他部局等, 研究員 2012: 東京大学, 医学部附属病院, 助教 2011 – 2012: 東京大学, 医学部附属病院, 臨床登録医 2008 – 2010: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, 医学部・附属病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Epidemiology and preventive medicine / Basic Section 55020:Digestive surgery-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator 膵癌 / 胆道学、膵臓学 / 遺伝子異常 / 薬剤耐性 / マウスモデル / 欠失 / CYP2C19 / 胆道癌 / LOH(ヘテロ接合性の消失) / 遺伝子増幅 / 高密度オリゴヌクレオチドアレイ / 高密度SNPアレイ / 膵臓病学 … More Except Principal Investigator … More H. bilis / H. hepaticus / 胆汁 / Helicobacter bilis / Helicobacter hepaticus / ERCP / 胆道がん / 膵がん / 化学療法選択 / Caveolin-1発現 / 膵癌EUS-FNA検体 / 肝内胆管がん / 肝外胆管がん / 胆のうがん予防 / 生活習慣 / 要因の交互作用 / Helicobacter属抗体 / 胆道がんの予防 / ゲノムワイド関連解析 / 胆嚢がんリスク / Snips / 胆道がんリスク / case control study / Helicobacter Spps. / SNP / gallbladder cancer / bilially tract cancer / 血清抗体検査 / 腸肝型ヘリコバクター / 感染症 / H. pylori 非感染者 / PCRベースダイレクトシーケンス / モノクローナル抗体 / 抗体の交差反応性 / 細菌叢の網羅的解析 / 抗体測定系 / H. ｐｙlori非感染者 / 胆汁中Helicobacter 属細菌 / 抗体の保有状況 / H. pylori陰性対象 / メタゲノム解析 / 血漿中抗体 / 菌体 / GP2遺伝子 / 培養 / 抗体 / 抗体検査 / PCR / 種特異プライマー / 菌体抗原の精製 / 菌株の大量培養 / 血清 / 疫学 / 血漿 / Helicobacter pylori / 血漿抗体価 / 全菌体抗原EIA法 / ブラシ検体 / ヘリコバクター・ヘパティカス / ヘリコバクター・ビリス / ヘリコバクター・ピロリ / 全菌体抗原法 / ヘリコバクター・ピロリ感染 / ヘリコバクター・ヘパティカス感染 / ヘリコバクター・ビリス感染 / 血漿抗体 Less

Caveolin-1 expression in pancreatic cancer EUS-FNA specimens and establishment of clinical basis for chemotherapy selection
- Principal Investigator
  
  大庭篤志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
A molecular-epidemiological study on risk factors of gallbladder cancer
- Principal Investigator
  
  Kikuchi Shogo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Aichi Medical University
Intestinal and hepaticr infection and risk of biliary tract and pancreatic cancer
- Principal Investigator
  
  Kikuchi Shogo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Aichi Medical University
Infection of Helicobacter and risk of pancreatic and biliary tract cancer
- Principal Investigator
  
  Kikuchi Shogo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Aichi Medical University
The impact of activated PI3K signal on pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  SASAHIRA Naoki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Identification of Genomic Locus Related to Sensitivity Against Anticancer Drug and Predisposition of Pancreatic Cancer Using Comprehensive AnalysisPrincipal Investigator
- Principal Investigator
  
  SASAHIRA Naoki
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2022 2020 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Other

[Journal Article] Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.2022
- Author(s)
  Osaki T, Lin Y, Sasahira N, Ueno M, Yonezawa H, Hojo F, Okuda M, Matsuyama M, Sasaki T, Kobayashi S, Tezuka S, Tanaka K, Dan N, Kuruma S, Egawa N, Kamiya S, Kikuchi S.
- Journal Title
  
  Helicobacter
  
  Volume: 27(1) Issue: 1 Pages: 12866-12866
- DOI
  10.1111/hel.12866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03186, KAKENHI-PROJECT-21H03187, KAKENHI-PROJECT-17K09144, KAKENHI-PROJECT-21K10218, KAKENHI-PROJECT-21K10485
[Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer2020
- Author(s)
  林櫻松,(13名)笹平直樹（2名）上野誠（8名）大崎敬子、神谷茂（57名）、菊地正悟（1名）
- Journal Title
  
  Nature Communications
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04127
[Journal Article] Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1.2012
- Author(s)
  Nakai Y, Isayama H, Ijichi H, Sasaki T, Kogure H, Yagioka H, Miyabayashi K, Mizuno S, Yamamoto K, Mouri D, Kawakubo K, Yamamoto N, Hirano K, Sasahira N, Tateishi K, Tada M, Koike K.
- Journal Title
  
  Cancer Sci
  
  Volume: 103(8) Issue: 8 Pages: 1489-92
- DOI
  10.1111/j.1349-7006.2012.02311.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590756
[Journal Article] Comorbidity, not age, is prognostic inpatients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy.2011
- Author(s)
  Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Kogure H, Yagioka H, Yashima Y, Togawa O, Arizumi T, Matsubara S, Hirano K, Tada M, Omata M, Koike K.
- Journal Title
  
  Crit Rev Oncol Hematol
  
  Volume: 78(3) Issue: 3 Pages: 252-9
- DOI
  10.1016/j.critrevonc.2010.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590756
[Journal Article] Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas.2011
- Author(s)
  Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Yamamoto K, Kogure H, Sasaki T, Hirano K, Ijichi H, Tateishi K, Yoshida H, Koike K.
- Journal Title
  
  Gut
  
  Volume: 60(9) Issue: 9 Pages: 1249-53
- DOI
  10.1136/gut.2010.227306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590756
[Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer2011
- Author(s)
  Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y
- Journal Title
  
  Clin Biochem
  
  Volume: 44 Issue: 8-9 Pages: 576-581
- DOI
  10.1016/j.clinbiochem.2011.03.128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390015, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-22590756, KAKENHI-PROJECT-22659013
[Journal Article] Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer.2011
- Author(s)
  Isayama H, Nakai Y, Yamamoto K, Sasaki T, Mizuno S, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Arizumi T,Togawa O, Ito Y, Matsubara S, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K.
- Journal Title
  
  Oncology
  
  Volume: 80(1-2) Issue: 1-2 Pages: 97-101
- DOI
  10.1159/000328767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590756
[Journal Article] Impact of S-1 in patients withgemcitabine-refractory pancreatic cancerin Japan2010
- Author(s)
  Nakai Y, Isayama H, Sasaki T,Sasahira N, Kogure H, Hirano K, Tsujino T,Ijichi H, Tateishi K, Tada M, Omata M,Koike K.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 40(8) Issue: 8 Pages: 774-80
- DOI
  10.1093/jjco/hyq059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590756
[Journal Article]2009
- Author(s)
  笹平直樹, 多田稔, ほか
- Journal Title
  
  膵発癌関連因子肝胆膵 58巻
  
  Pages: 531-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590751
[Journal Article] Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution single nucleotide polymorphism array2008
- Author(s)
  淋連捷, 浅岡良成, 笹平直樹, 多田稔, ほか
- Journal Title
  
  Oncology 75巻
  
  Pages: 102-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590751
[Journal Article] Risk of pancreatic cancer in calcified chronic pancreatitis
- Author(s)
  笹平直樹, 多田稔, ほか
- Journal Title
  
  J Gastroenterol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590751
[Presentation] Eose extracorporeal shockwave lithotripsy combined with endotherapy really improve the natural course of chronic pancreatitis2011
- Author(s)
  Sasahira N.
- Organizer
  Digestive Disease Week (DDW)
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-22590756
[Presentation] Fully covered self-expandable metal stent (FCSEMS) for refractory pancreatic duct stricture associated with chronic pancreatitis.2010
- Author(s)
  Sasahira N.
- Organizer
  Asian Pacific Digestive Week 2010
- Place of Presentation
  Kuala Lumpur, Malaysia
- Data Source
  KAKENHI-PROJECT-22590756
[Presentation] Risk of pancreatic cancer in calcified chronic pancreatitis2009
- Author(s)
  笹平直樹, 多田稔, ほか
- Organizer
  ヨーロッパ消化器病学会2009
- Place of Presentation
  ロンドン
- Year and Date
  2009-11-24
- Data Source
  KAKENHI-PROJECT-19590751
[Presentation] 慢性膵炎からの発癌とその特徴2009
- Author(s)
  笹平直樹, 多田稔, ほか
- Organizer
  第95回日本消化器病学会総会
- Place of Presentation
  札幌
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-19590751
[]
[]

1. Kikuchi Shogo (40224901)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. OSAKI Takako (90255406)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 上野誠 (10520760)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. TADA Minoru (80302719)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. ASAOKA Yoshinari (90431858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. IKENOUE Tsuneo (80396712)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 神谷茂 (10177587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. IJICHI Hideaki (70463841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. LIN Yingsong (50340302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 森満 (50175634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中尾春壽 (60326139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 来間佐和子 (90627639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 奥田真珠美 (40531091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 福田能啓 (60148640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 石井浩 (70521855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中杤昌弘 (10559983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 米澤英雄 (60453528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 櫻井美佳 (80508359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大庭篤志 (70740257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高松学 (00750366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐々木隆 (10569106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 廣瀬雄己 (10737365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高橋祐 (30595517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 井上陽介 (50597747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DAN Naoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. EGAWA Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 大さき敬子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 青木淳賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasahira Naoki 笹平 直樹

笹平 直樹 ササヒラ ナオキ

SASAHIRA Naoki 笹平 直樹

Research Projects

Research Products

Co-Researchers

Caveolin-1 expression in pancreatic cancer EUS-FNA specimens and establishment of clinical basis for chemotherapy selection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A molecular-epidemiological study on risk factors of gallbladder cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intestinal and hepaticr infection and risk of biliary tract and pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Infection of Helicobacter and risk of pancreatic and biliary tract cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The impact of activated PI3K signal on pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Genomic Locus Related to Sensitivity Against Anticancer Drug and Predisposition of Pancreatic Cancer Using Comprehensive AnalysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prevalence estimates of Helicobacter species infection in pancreatic and biliary tract cancers.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer2020

Author(s)

Journal Title

Data Source

[Journal Article] Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comorbidity, not age, is prognostic inpatients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of S-1 in patients withgemcitabine-refractory pancreatic cancerin Japan2010

Author(s)

Journal Title

DOI

Sasahira Naoki 笹平直樹

笹平直樹ササヒラナオキ

SASAHIRA Naoki 笹平直樹