Hirose Yuki 廣瀬雄己

… Alternative Names

廣瀬雄己ヒロセユウキ

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Researcher Number	10737365
Other IDs
Affiliation (Current)	2023: 新潟大学, 医歯学総合病院, 助教
Affiliation (based on the past Project Information) *help	2023: 新潟大学, 医歯学総合病院, 助教 2019 – 2022: 新潟大学, 医歯学総合研究科, 客員研究員 2018 – 2021: 新潟大学, 医歯学総合病院, 特任助教 2014 – 2016: 新潟大学, 医歯学総合病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator S1P / 肝細胞癌 / スフィンゴ脂質 / SphK1 / TCGA / 免疫組織化学 / セラミド / スフィンゴシン-1-リン酸 / 脈管侵襲 / 抗がん剤耐性 … More / 変異シグネチャー / ターゲット遺伝子パネル検査 / バイオインフォマティクス / 消化器癌 / 固形癌 / 塩基置換 / 遺伝子パネル検査 / mutational signature … More Except Principal Investigator 脂質メディエーター / 食道癌 / 術前化学療法 / NQO1 / 細菌叢 / 食道外科学 / 術前補助化学療法 / 酸化ストレス / 治療抵抗性 / 大腸癌 / 抗癌剤耐性 / KRAS / Nrf2 / Keap1 / p62 / 胃癌 / 相同組換え修復 / がん遺伝子パネル検査 / 白金系抗癌剤 / homologous recombination / 癌遺伝子パネル / mutational signature / DNA二重鎖切断 / 化学療法 / ヒト共生細菌叢 / 癌遺伝子異常 / 消化器 / 伝播経路 / 薬物療法 / バイオマーカー / 体液 / 潰瘍性大腸炎 / 回腸嚢炎 / スフィンゴシン-1-リン酸 / 炎症 / 腸内細菌叢 / 膵癌 / S1P / SphK1 / 免疫微小環境 / 膵島移植 / セラミド / 遺伝子多型 / 大腸がん / BRAF変異 / 粘液形質 Less

BRAF変異陽性の大腸癌における分子病理学的特徴を加味した新しい分類法の確立
- Principal Investigator
  
  中野麻恵
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
食道癌術前化学療法の治療効果予測を目指したNQO1遺伝子多型の臨床的意義の解明
- Principal Investigator
  
  石川卓
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
変異シグネチャー解析による固形癌の塩基置換パターン分類の確立及び臨床的意義の解明Principal Investigator
- Principal Investigator
  
  廣瀬雄己
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
潰瘍性大腸炎術後回腸嚢炎の発症機序解明：腸内細菌叢および脂質メディエーターの解析
- Principal Investigator
  
  亀山仁史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
膵癌患者の免疫微小環境における脂質メディエーター分子の役割と臨床的意義
- Principal Investigator
  
  滝沢一泰
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
セラミドによる免疫制御機構を応用した膵島移植における膵島生着延長の試み
- Principal Investigator
  
  小林隆
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Niigata University
Elucidation of the interaction between human commensal bacterial flora and host genetic alterations in the digestive tract
- Principal Investigator
  
  Wakai Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Niigata University
The role of lipid mediators for lymphvascular invasion in hepatocellular carcinoma and its clinical significancePrincipal Investigator
- Principal Investigator
  
  Hirose Yuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
Clinical significance of defective DNA double-strand break repair pathway in gastric cancer
- Principal Investigator
  
  Katada Tomohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Niigata University
Oxidative stress signaling as the molecular mechanism of chemo-resistance in esophageal cancer
- Principal Investigator
  
  KOSUGI Shin-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Niigata University
Elucidation of the mechanism of drug resistance in colorectal cancer by p62-Keap 1-Nrf2 pathway
- Principal Investigator
  
  KAMEYAMA Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Niigata University

All 2021 2020 2019 2018 2017 2016 Other

All Journal Article Presentation

[Journal Article] Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer.2021
- Author(s)
  Okuda S, Shimada Y, Tajima Y, Yuza K, Hirose Y, Ichikawa H, Nagahashi M, Sakata J, Ling Y, Miura N, Sugai M, Watanabe Y, Takeuchi S, Wakai T
- Journal Title
  
  Comput Struct Biotechnol J
  
  Volume: 19 Pages: 3330-3338
- DOI
  10.1016/j.csbj.2021.05.049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22651, KAKENHI-PROJECT-21K17850
[Journal Article] Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine‐1‐phosphate and ceramide in human hepatocellular carcinoma2021
- Author(s)
  Miura Kohei、Nagahashi Masayuki、Prasoon Pankaj、Hirose Yuki、Kobayashi Takashi、Sakata Jun、Abe Manabu、Sakimura Kenji、Matsuda Yasunobu、Butash Ali L.、Katsuta Eriko、Takabe Kazuaki、Wakai Toshifumi
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Issue: 5 Pages: 614-626
- DOI
  10.1111/hepr.13625
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18K08672
[Journal Article] Inguinal Herniation After Living Donor Kidney Transplantation: A Case Report.2020
- Author(s)
  Kobayashi T, Miura K, Saito K, Tasaki M, Saito K, Sakata J, Takizawa K, Katada T, Hirose Y, Yuza K, Ando T, Nagahashi M, Kameyama H, Wakai T.
- Journal Title
  
  Transplant Proc
  
  Volume: 52 Issue: 6 Pages: 1940-1943
- DOI
  10.1016/j.transproceed.2020.02.131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21628
[Journal Article] Living donor liver transplantation for more than 30-year survived patients with native liver after Kasai operation for biliary atresia2020
- Author(s)
  Kobayashi T, Miura K, Kubota M, Kinoshita Y, Sakata J, Takizawa K, Katada T, Hirose Y, Yuza K, Ando T, Miura Y, Nagahashi M, Kameyama H, Wakai T
- Journal Title
  
  Transplantation Reports
  
  Volume: 5 Pages: 100052-100052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21628
[Journal Article] Clinical significance of NQO1 expression in patients with advanced KRAS wild colorectal cancer2017
- Author(s)
  Hitoshi Kameyama, Yuki Hirose, Yasunobu Matsuda, Masayuki Nagahashi, Hiroshi Ichikawa, You Sato, Saki Yamada, Shinnosuke Hotta, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462006
[Journal Article] Prognostic significance of NQO1 expression in esophageal squamous cell carcinoma after preoperative chemotherapy with cisplatin and 5-fluorouracil followed by curative esophagectomy2016
- Author(s)
  Ichikawa H, Kosugi S, Hirose Y, Matsuda Y, Ishikawa T, Hanyu T, Usui K, Muneoka Y, Nagahashi M, Sakata J, Kobayashi T, Kameyama H, Wakai T
- Journal Title
  
  International Journal of Clinical and Experimental Pathology
  
  Volume: 9 Pages: 7393-7401
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461971
[Presentation] Effect of exenatide on swine islet autotransplantation model2021
- Author(s)
  Kobayashi T, Miura K, Ishikawa H, Toge K, Hirose Y, Takizawa K, Sakata J, Wakai T, Kinoshita Y
- Organizer
  The 17th Congress of the Asian Society of Transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21628
[Presentation] Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer 大腸癌における宿主の遺伝子変異と腫瘍内細菌叢のプロファイリング2021
- Author(s)
  Toshifumi Wakai, Shujiro Okuda, Yoshifumi Shimada, Yosuke Tajima, Yuki Hirose, Hiroshi Ichikawa, Yiwei Ling, Nobuaki Miura, Mika Sugai, Yu Watanabe, Shiho Takeuchi, Jun Sakata
- Organizer
  The 32nd Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22651
[Presentation] 慢性炎症による癌の増殖・転移を促進する脂質メディエーター分子機構2020
- Author(s)
  永橋昌幸, 土田純子, 油座築, 諸和樹, 根本万里子, 廣瀬雄己, 利川千絵, 五十嵐麻由子, 三浦宏平, 田島陽介, 市川寛, 羽入隆晃, 滝沢一泰, 中島真人, 島田能史, 小林隆, 坂田純, 石川卓, 亀山仁史, 若井俊文
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K09074
[Presentation] Defective Homologous Recombination in Platinum-based Chemotherapy for Gastric Cancer2019
- Author(s)
  T. Katada, H. Ichikawa, Y. Hirose, M. Nagahashi, Y. Shimada, T. Hanyu, T. Ishikawa, Y. Kano, Y. Muneoka, J. Sakata, T. Kobayashi, H. Kameyama, T. Wakai
- Organizer
  14th Annual Academic Surgical Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08698
[Presentation] 肝細胞癌患者における脂質メディエーター・スフィンゴシン-1-リン酸及びセラミドの定量とその意義2018
- Author(s)
  永橋昌幸, 廣瀬雄己, 三浦宏平, 油座築, 相馬大輝, 安藤拓也, 峠弘治, 石川博輔, 堅田朋大, 坂田純, 小林隆, 中島真人, 羽入隆晃, 市川寛, 石川卓, 島田能史, 亀山仁史, 高部和明, 若井俊文
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K08672
[Presentation] 大腸癌化学療法におけるNQO1発現解析の意義2016
- Author(s)
  亀山仁史，廣瀬雄己，島田能史，八木亮磨，田島陽介，岡村拓磨，中野雅人，市川　寛，永橋昌幸，坂田　純，小林　隆，若井俊文
- Organizer
  JDDW 2016
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-26462006
[Presentation] Clinical significance of NQO1 expression in patients with KRAS wild-type unresectable colorectal cancer2016
- Author(s)
  Hitoshi Kameyama, Yuki Hirose, Yoshifumi Shimada, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Masayuki Nagahashi, Takashi Kobayashi, Toshifumi Wakai
- Organizer
  IASGO 2016
- Place of Presentation
  Seoul (South Korea)
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462006
[Presentation] 進行再発大腸癌におけるNQO1発現の臨床的意義
- Author(s)
  亀山仁史，廣瀬雄己，佐藤　洋，山田沙季，阿部　馨，庭野稔之，岩城孝和，八木亮磨，田島陽介，中野麻恵，中野雅人，島田能史，坂田　純，小林　隆，皆川昌広，小杉伸一，小山　諭，若井俊文
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2014-04-16 – 2014-04-18
- Data Source
  KAKENHI-PROJECT-26462006
[Presentation] NQO1 EXPRESSION HAS PROGNOSTIC SIGNIFICANCE IN KRAS-WILD UNRESECTABLE COLORECTAL CANCER
- Author(s)
  Y. Hirose, H. Kameyama, T. Ohashi, K. Takizawa, M. Nagahashi, T. Kobayashi, J. Sakata, T. Wakai
- Organizer
  46th World Congress of Surgery
- Place of Presentation
  Bangkok
- Year and Date
  2015-08-23 – 2015-08-27
- Data Source
  KAKENHI-PROJECT-26462006

1. Wakai Toshifumi (50372470)

# of Collaborated Projects: 9 results

# of Collaborated Products: 10 results
2. 永橋昌幸 (30743918)

# of Collaborated Projects: 8 results

# of Collaborated Products: 10 results
3. 市川寛 (50721875)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
4. 島田能史 (20706460)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
5. KOSUGI Shin-ichi (90401736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. 油座築 (00745565)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
7. 坂田純 (70447605)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. KAMEYAMA Hitoshi (40626420)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
9. 小林隆 (40464010)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
10. 三浦宏平 (70733658)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
11. 奥田修二郎 (00512310)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
12. KOMATSU Masaaki (90356254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 石川卓 (70586940)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. 羽入隆晃 (50719705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
15. 小山諭 (10323966)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
16. 松田康伸 (40334669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
17. 中野麻恵 (20790281)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 竹内志穂 (70422277)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 田島陽介 (30757505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
20. 諸和樹 (10745566)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 須貝美佳 (10772030)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. Katada Tomohiro (20815782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 味岡洋一 (80222610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 西條康夫 (10270828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 中島真人 (60588250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. 中野雅人 (70744788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 小柳英人 (70831725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 滝沢一泰 (30706437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 長櫓宏規 (90888033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 木下義晶 (80345529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
31. 宗岡悠介 (00769391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 赤澤宏平 (10175771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 加納陽介 (90745580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 阿部馨 (90745556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 大関瑛 (50975646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 崎村建司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirose Yuki 廣瀬 雄己

廣瀬 雄己 ヒロセ ユウキ

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変異シグネチャー解析による固形癌の塩基置換パターン分類の確立及び臨床的意義の解明Principal Investigator

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The role of lipid mediators for lymphvascular invasion in hepatocellular carcinoma and its clinical significancePrincipal Investigator

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[Journal Article] Profiling of host genetic alterations and intra-tumor microbiomes in colorectal cancer.2021

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[Journal Article] Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine‐1‐phosphate and ceramide in human hepatocellular carcinoma2021

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[Journal Article] Inguinal Herniation After Living Donor Kidney Transplantation: A Case Report.2020

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[Journal Article] Living donor liver transplantation for more than 30-year survived patients with native liver after Kasai operation for biliary atresia2020

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Hirose Yuki 廣瀬雄己

廣瀬雄己ヒロセユウキ