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Hayashi Hiroki  林 洋毅

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HIROKI Hayashi  林 洋毅

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Researcher Number 30422124
Other IDs
Affiliation (based on the past Project Information) *help 2020 – 2022: 東北大学, 医学系研究科, 大学院非常勤講師
2019: 東北大学, 医学系研究科, 准教授
2017 – 2018: 東北大学, 大学病院, 講師
2011 – 2013: 東北大学, 大学病院, 助教
2007 – 2013: Tohoku University, 病院, 助教
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Digestive surgery
Keywords
Principal Investigator
上皮増殖因子受容体 / 胆道癌 / 二重特異性抗体 / 免疫療法 / クロモスリプシス / 染色体不安定性 / テロメア / バイオマーカー / 胆嚢癌 / 胆管癌 … More / 膵癌 / 外科 / 癌 / 一本鎖抗体 / 緑色蛍光タンパク / 緑色蛍光タンパク質 / 養子免疫療法 / EGFR … More
Except Principal Investigator
胆道癌 / 自家骨髄細胞移植 / 大量肝切除 / 肝再生 / 骨髄幹細胞 / SEREX法 / 樹状細胞 / 化学療法 / 腫瘍特異的抗原 / WT1ペプチドワクチン / 免疫療法 / プロテオミクス / WT1 / 腫瘍関連抗原 / 膵癌 / ペプチドワクチン / 遺伝子 / 胆管癌 / Fbw7 / ユビキチンリガーゼ Less
  • Research Projects

    (7 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (14 People)
  •  Early detection and precision medicine for hepatobiliiary cancer targeting chromosomal instabilityPrincipal Investigator

    • Principal Investigator
      Hayashi Hiroki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Tohoku University
  •  Construction and clinical application of cancer visualization system using single-chain artificial antibody conjugated with green fluorescent proteinPrincipal Investigator

    • Principal Investigator
      Hayashi Hiroki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  cancer molecule targetting therapy with quad functional next-generationartificial bispecific antibodyPrincipal Investigator

    • Principal Investigator
      HAYASHI HIROKI
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Analysis of carcinogenic mechanism of biliary tract cancer from the protein control by ubiquitin ligase Fbw7

    • Principal Investigator
      KATAYOSE Yu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Establishment of specific cancer vaccination therapy for pancreatic and biliary cancer.

    • Principal Investigator
      EGAWA Shinichi
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  Research and development of liver regeneration with autologous bone marrow cell transplantation against the limitation of major hepatectomy

    • Principal Investigator
      RIKIYAMA Toshiki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Jichi Medical University
      Tohoku University
  •  Adoptive immunotherapy using bispecific antibody that blocks theEGFR signaling pathwayPrincipal Investigator

    • Principal Investigator
      HIROKI Hayashi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University

All 2019 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer2014

    • Author(s)
      Yamaue H, et al
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73(1) Issue: 1 Pages: 97-102

    • DOI

      10.1007/s00280-013-2323-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23390331, KAKENHI-PROJECT-24592037, KAKENHI-PROJECT-25670560
  • [Journal Article] 【胆嚢癌の診断と治療】胆嚢癌の進行度診断2013

    • Author(s)
      菅野敦,正宗淳,林洋毅,海野倫明,下瀬川徹
    • Journal Title

      日本消化器病学会雑誌

      Volume: 110(8) Pages: 1400-1407

    • Data Source
      KAKENHI-PROJECT-23791512
  • [Journal Article] The expression of S100A4 in human pancreatic cancer is associated with invasion2013

    • Author(s)
      Tsukamoto N, et al
    • Journal Title

      Pancreas

      Volume: 42(6) Issue: 6 Pages: 1027-33

    • DOI

      10.1097/mpa.0b013e31828804e7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390253, KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-25462673
  • [Journal Article] Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody2013

    • Author(s)
      Ryutaro Asano, el al.
    • Journal Title

      Protein Eng. Des. Sel.

      Volume: 26 Issue: 5 Pages: 359-367

    • DOI

      10.1093/protein/gzt009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23686118, KAKENHI-PROJECT-23791512, KAKENHI-PROJECT-24000011, KAKENHI-PROJECT-25420836, KAKENHI-PROJECT-25640085
  • [Journal Article] Potential Utility of NOG Mice with Ubiquitous eGFP Expression (NOG-EGFP) as a High Quality Cancer Sampling System2012

    • Author(s)
      Shima K, Mizuma M, Hayashi H, Nakagawa K, Okada T, Sakata N, Omura N, Kitamura Y, Motoi F, Naito T, Rikiyama T, Katayose Y, Egawa S, Ishii N, Horii A, Unno M
    • Journal Title

      J Exp Clin Cancer Res.

      Volume: 31(1)

    • Data Source
      KAKENHI-PROJECT-22591498
  • [Journal Article] Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system.2012

    • Author(s)
      Ryutaro Asano
    • Journal Title

      FEBS J.

      Volume: 279 Issue: 2 Pages: 223-233

    • DOI

      10.1111/j.1742-4658.2011.08417.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650227, KAKENHI-PROJECT-23686118, KAKENHI-PROJECT-23790136, KAKENHI-PROJECT-23791512
  • [Journal Article] 【胆嚢癌フロントライン】薬物治療胆嚢癌外科切除後adjuvant chemotherapyの現状2012

    • Author(s)
      林洋毅,海野倫明
    • Journal Title

      肝・胆・膵

      Volume: 64(4) Pages: 607-612

    • Data Source
      KAKENHI-PROJECT-23791512
  • [Journal Article] 臓器別最新データ胆道癌の疫学外科医のための癌診療データ2012

    • Author(s)
      林洋毅,海野倫明
    • Volume
      67(11)
    • Pages
      179-185
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Journal Article] Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma2012

    • Author(s)
      Katayose Y, Nakagawa K, Yamamoto K, Yoshida H, Hayashi H, Mizuma M, Ohtsuka H, Fukase K, Onogawa T, Motoi F, Rikiyama T, Egawa S, Unno M
    • Journal Title

      Hepatogastroenterology

      Volume: 59(118) Pages: 1758-1760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390252
  • [Journal Article] 切除不能胆管癌の予後と治療戦略2012

    • Author(s)
      林洋毅,海野倫明
    • Journal Title

      消化器内科

      Volume: 55(3) Pages: 367-371

    • Data Source
      KAKENHI-PROJECT-23791512
  • [Journal Article] In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody2011

    • Author(s)
      Watanabe Y, Yasui H, et al
    • Journal Title

      Oncol Rep

      Volume: 26(4) Pages: 949-55

    • DOI

      10.3892/or.2011.1382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790917, KAKENHI-PROJECT-23591399, KAKENHI-PROJECT-23650227, KAKENHI-PROJECT-23686118, KAKENHI-PROJECT-23790136, KAKENHI-PROJECT-23791512
  • [Journal Article] Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study)2011

    • Author(s)
      Katayose Y, Rikiyama T, Motoi F, Yamamoto K, Yoshida H, Morikawa T, Hayashi H, Kanno A, Hirota M, Satoh K, Ariga H, Suzuki M, Ohyauchi M, Kondo Y, Ikeya S, Ogawa Y, Shimosegawa T, Egawa S, Unno M.
    • Journal Title

      Hepatogastroenterology

      Volume: 58(112) Pages: 1866-1872

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390252
  • [Journal Article] 食道癌術後胃管浸潤を来した広義の肝門部胆管癌および下咽頭癌の同時性重複癌の1例2010

    • Author(s)
      高舘達之、山本久仁治、森川孝則、小野川徹、志賀清人、小林俊光、元井冬彦、力山敏樹、片寄友、江川新一、海野倫明
    • Journal Title

      日本胆道学会雑誌

      Volume: 24 Pages: 204-208

    • NAID

      10030361322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390253
  • [Journal Article] 膵癌に対するWT1ペプチドワクチン治療の背景2010

    • Author(s)
      江川新一、町田恭穂、林洋毅、北村洋、深瀬耕二、乙供茂、大塚英郎、森川孝則、水間正道、坂田直昭、中川圭、吉田寛、元井冬彦、内藤剛、力山敏樹、片寄友、海野倫明
    • Journal Title

      胆と膵

      Volume: 32 Pages: 141-144

    • Data Source
      KAKENHI-PROJECT-22390253
  • [Journal Article] Application of the Fc fusion format to generate tag-free bi-specific diabodies.2010

    • Author(s)
      Asano R, Ikoma K, Kawaguchi H, Ishiyama Y, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I
    • Journal Title

      FEBS J 277(2)

      Pages: 477-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Journal Article] Target cell-restricted apoptosis induction by 528scFv-TRAIL fusion protein specific for human EGFR and expressed in Escherichia coli.2010

    • Author(s)
      Badran A, Asano R, Nakayama M, Watanabe Y, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kumagai I
    • Journal Title

      Int J Oncol 36(5)

      Pages: 1229-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Journal Article] Preferential heterodimerization of a bispecific diabody based on a humanized anti-EGFR antibody 528.2008

    • Author(s)
      Asano R, Sone Y, Ikoma K, Hayashi H, Nakanishi T, Umetsu M, Katayose Y, Unno M, Kudo T, Kumagai I
    • Journal Title

      Protein Eng Des Sel 21(10)

      Pages: 597-603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Journal Article] Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells.2008

    • Author(s)
      Asano R, Kawaguchi H, Watanabe Y, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I
    • Journal Title

      J Immunother 31(8)

      Pages: 752-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Journal Article] Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells.2007

    • Author(s)
      Asano R, Watanabe Y, Kawaguchi H, Fukazawa H, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I
    • Journal Title

      J Biol Chem 282(38)

      Pages: 27659-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Presentation] The therapeutic strategy for locally advanced unresectable pancreatic cancer patients: Conversion surgery after chemotherapy and chemoradiotherapy2019

    • Author(s)
      林 洋毅
    • Organizer
      日本肝胆膵外科学会
    • Data Source
      KAKENHI-PROJECT-17K10685
  • [Presentation] Efficacy of conversion surgery for initially unresectable pancreatic cancer2019

    • Author(s)
      林 洋毅
    • Organizer
      日本消化器外科学会
    • Data Source
      KAKENHI-PROJECT-17K10685
  • [Presentation] Impact of additional resection for incidental gallbladder cancer2014

    • Author(s)
      Hayashi H, Motoi F, Yoshida H, Morikawa T, Okada T, Nakagawa K, Naitoh T, Katayose Y, Unno M.
    • Organizer
      International Hepatp-Pancreato-Biliary Association 2014 11th World Congress
    • Place of Presentation
      韓国・ソウル
    • Year and Date
      2014-03-25
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] 胆道癌における上皮増殖因子受容体(EGFR)発現率およびKRAS・BRAF遺伝子変異率の検討2013

    • Author(s)
      林洋毅,元井冬彦,吉田寛,森川孝則,中川圭,大塚英郎,水間正道,片寄友,海野倫明
    • Organizer
      第49回日本胆道学会学術集会
    • Place of Presentation
      舞浜
    • Year and Date
      2013-09-19
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] 蛍光 NOG マウスの異種移植モデルを用いた高純度癌細胞サンプリングシステム2013

    • Author(s)
      嶋健太郎,水間正道, 林 洋毅, 中川 圭, 岡田恭穂, 坂田直昭, 大村範幸, 北村 洋, 吉田 寛, 元井冬彦, 力山敏樹, 片寄 友, 江川新一, 石井直人, 堀井 明 , 海野倫明
    • Organizer
      第113回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591498
  • [Presentation] Stage3以上の進行胆道癌における予後規定因子の検討ならびに手術適応の検討2012

    • Author(s)
      林洋毅,力山敏樹,元井冬彦,吉田寛,小野川徹,森川孝則,岡田恭穂,中川圭,大塚英郎,坂田直昭,乙供茂,水間正道,深瀬耕二,石田晶玄,片寄友,江川新一,海野倫明
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-12
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] T2胆嚢癌における術式の検討2012

    • Author(s)
      林洋毅,力山敏樹,元井冬彦,吉田寛,中川圭,森川孝則,岡田恭穂,片寄友,江川新一,海野倫明
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-18
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] 早期再発例と長期生存例の病理組織学的因子の比較からみた進行胆嚢癌の手術適応2012

    • Author(s)
      林洋毅,片寄友,吉田寛,森川孝則,中川圭,岡田恭穂,元井冬彦,内藤剛,江川新一,海野倫明
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Year and Date
      2012-07-18
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] 胆道癌再発症例に対する再発巣切除の意義2012

    • Author(s)
      林洋毅,片寄友,海野倫明
    • Organizer
      第48回日本胆道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] 高度局所進行胆嚢癌の治療戦略と術式選択2012

    • Author(s)
      林洋毅,力山敏樹,元井冬彦,吉田寛,森川孝則,岡田恭穂,中川圭,大塚英郎,乙供茂,水間正道,坂田直昭,深瀬耕二,石田晶玄,片寄友,江川新一,海野倫明
    • Organizer
      第24回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-06-01
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] The Risk Evaluation about Major Hepato-Pancreaticoduocenectomy for Cholangiocarcinoma; 24 cases2011

    • Author(s)
      Hayashi H, Rikiyama T, Motoi F, Onogawa T, Morikawa T, Okada T, Nakagawa K, Ohtsuka H, Ottomo S, Mizuma M, Sakata N, Fukase K, Katayose Y, Egawa S, Unno M.
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (lASG02011 in Tokyo)
    • Place of Presentation
      東京
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] Pilot trial of Wilms Tumor 1 (WT1) peptide vaccine therapy for chemorefractory advanced pancreatic cancer2011

    • Author(s)
      Egawa S, Okada T, Hayashi H, Kitamura Y, Ottomo S, Fukase K, Ohtsuka H, Morikawa T, Mizuma M, Sakata N, Nakagawa K, Yoshida H, Onogawa T, Motoi F, Naito T, Rikiyama T, Katayose Y, Nishida S, Oka Y, Sugiyama H, Unno M
    • Organizer
      5^<th> Intenational Conference of WT1 in Human Neoplasia
    • Place of Presentation
      イタリア・トリノ
    • Year and Date
      2011-04-15
    • Data Source
      KAKENHI-PROJECT-22390253
  • [Presentation] 切除不能胆管癌の予後の検討と治療戦略2011

    • Author(s)
      林洋毅,片寄友,海野倫明
    • Organizer
      JDDW2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-23791512
  • [Presentation] An attempt to establish a high quality sampling system of cancer cells using a xenograft model of NOG-EGFP mice.2011

    • Author(s)
      嶋健太郎,水間正道, 大村範幸, 林 洋毅, 中川 圭, 岡田恭穂, 元井冬彦, 力山敏樹, 片寄 友, 江川新一, 石井直人, 堀井 明, 海野倫明
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22591498
  • [Presentation] EGFRとCD3を標的とした新規ヒト型化二重特異性抗体の抗腫瘍効果の検討2009

    • Author(s)
      林洋毅
    • Organizer
      第13回がん分子標的治療学会
    • Place of Presentation
      ホテルクレメント徳島
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Presentation] GFRとCD3を標的とした新規ヒト型化二重特異性抗体の抗腫瘍効果の検討2009

    • Author(s)
      林洋毅、海野倫明:
    • Organizer
      第13回がん分子標的治療学会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PROJECT-19790934
  • [Presentation] EGFR標的ヒト型化二重特異性抗体のセツキシマブとの比較検討.2008

    • Author(s)
      渡部泰弘、林洋毅、浅野竜太郎、吉田寛、片寄友、安井寛、石田禎夫、江川新一、熊谷泉 、海野倫明
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Data Source
      KAKENHI-PROJECT-19790934
  • 1.  KATAYOSE Yu (20302151)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  YAMAMOTO Kuniharu (00375073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  YOSHIDA Hiroshi (60436152)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  NAKAGAWA Kei (20542294)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  EGAWA Shinichi (00270679)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  SAKATA Naoaki (50431565)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  OKADA Takaho (10375074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  RIKIYAMA Toshiki (80343060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  UNNO Michiaki (70282043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  中山 啓子 (60294972)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  浅野 竜太郎 (80323103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  畠 達夫 (30806237)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  青木 修一 (30844451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  YASUI Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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