WATANABE Sumiyo 渡邉秀美代

Researcher Number	30422314
Affiliation (based on the past Project Information) *help	2013 – 2015: 東京大学, 医学(系)研究科(研究院), 研究員 2012: 東京大学, 医学(系)研究科(研究院), 特任研究員 2011: 東京大学, 大学院・医学系研究科, 特任研究員 2010: 帝京大学, 医学部, 助手 2008 – 2009: The University of Tokyo, 医学部附属病院, 医員 2007: The University of Tokyo, 医学部・附属病院, 医員
Review Section/Research Field	Principal Investigator Kidney internal medicine
Keywords	Principal Investigator 遺伝子治療 / 腎不全 / 慢性腎不全 / 腎移植 / siRNA治療 / siRNAデリバリー / 癌治療 / 腎移植拒絶反応抑制 / 核酸治療 / siRNAキャリア … More / siRNAキャリアー / siRNA / 免疫寛容 / 腎移植拒絶反応 / 足細胞特異的p130-casノックアウト / 足細胞 / ナノキャリアー / アルブミン尿 / cas L / p130-cas / ナノキャリア / p130-Cas / 腎足細胞 / 高リン血症 / 高カリウム血症 / 低カルシウム血症 / 腎電解質代謝 / カルシウム感知受容体 / 遺伝子治療3 / 骨異栄養症 / 低Ca血症 / 腎電解質異常 / Ca感知受容体 / 副甲状腺機能低下症 / 腎機能低下 / カルシウム代謝 / バーター症候群 Less

siRNA carrier strategy to inhibit to rejection of transplanted kidneysPrincipal Investigator
- Principal Investigator
  
  Watanabe Sumiyo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Does the podocyte damage is non-invertible? Inquest therapeutic modality for the damage.Principal Investigator
- Principal Investigator
  
  WATANABE Sumiyo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
  Teikyo University
Where is the cause of Bartter's syndrome in the kidney?Principal Investigator
- Principal Investigator
  
  WATANABE Sumiyo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] 症候群ハンドブック2011
- Author(s)
  井村裕矢, 他(渡邉秀美代含む)
- Total Pages
  757
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22890196
[Book] 症候群ハンドブック2011
- Author(s)
  渡邉秀美代、内田俊也
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22890196
[Book] 症候群ハンドブック2011
- Author(s)
  渡邉秀美代、内田俊也、編集:福井次矢/辻省次,総編集:井村裕夫
- Total Pages
  792
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22890196
[Journal Article] Influence of RNA strand rigidity on polyion complex formation with block catiomers.2016
- Author(s)
  K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
- Journal Title
  
  Macromol. Rapid Commun.
  
  Volume: 37 Issue: 6 Pages: 486-493
- DOI
  10.1002/marc.201500661
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331, KAKENHI-PROJECT-14J10626, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141
[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014
- Author(s)
  Hyun Jin Kim, Takehiko Ishii, Meng Zheng, Sumiyo Watanabe, Kazuko Toh, Yu Matsumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Journal Title
  
  Drug Delivery and Translational Research
  
  Volume: 4 Issue: 1 Pages: 50-60
- DOI
  10.1007/s13346-013-0175-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03349, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-23790043, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-24790530, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141, KAKENHI-PROJECT-26670738
[Journal Article] Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia.2014
- Author(s)
  Kinoshita Y, Hori M, Taguchi M, Watanabe S, Fukumoto S.
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 99(2) Pages: 363-368
- Data Source
  KAKENHI-PROJECT-24659411
[Journal Article] Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles2014
- Author(s)
  F. Pittella, N. Nishiyama, et al.
- Journal Title
  
  J. Control. Release
  
  Volume: 178 Pages: 18-24
- DOI
  10.1016/j.jconrel.2014.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13F03042, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141, KAKENHI-PROJECT-25670010, KAKENHI-PROJECT-25750172
[Journal Article] ニコランジル　慢性腎不全モデルラットでのポドサイトとマクロファージをターゲットとした新しい治療薬(2013
- Author(s)
  • 田村好古(帝京大学医学部内科学講座), 仲川孝彦, 浅川信一郎, 奈倉倫人, 大野弘毅, 小菅正裕, 加藤秀樹, 野坂仁也, 渡邉秀美代, 日野雅予, 内田俊也
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 55-3 Pages: 346-346
- Data Source
  KAKENHI-PROJECT-24659411
[Journal Article] 常染色体優性低カルシウム(Ca)血症(ADH)の臨床的重症度と生化学的指標の関係2013
- Author(s)
  木下祐加, 堀倫子, 田口学, 渡邉秀美代, 福本誠二
- Journal Title
  
  日本内分泌学会雑誌
  
  Volume: 89-1 Pages: 252-252
- Data Source
  KAKENHI-PROJECT-24659411
[Journal Article] Biomolecular Robotics for Chemomechanically Driven Guest Delivery Fuelled by Intracellular ATP2013
- Author(s)
  S.Biswas, K.Kinbara, T.Niwa, H.Taguchi, N.Ishii, S.Watanabe, K.Miyata, K.Kataoka and T.Aida
- Journal Title
  
  Nature Chemistry
  
  Volume: 5 Issue: 7 Pages: 613-620
- DOI
  10.1038/nchem.1681
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20111010, KAKENHI-PROJECT-21675003, KAKENHI-PLANNED-23115003, KAKENHI-PUBLICLY-24113705, KAKENHI-PROJECT-24657070, KAKENHI-PROJECT-24659411
[Journal Article] Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles2012
- Author(s)
  F. Pittella, K. Miyata
- Journal Title
  
  J. Control.Release
  
  Volume: 161 Issue: 3 Pages: 868-874
- DOI
  10.1016/j.jconrel.2012.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700489, KAKENHI-PROJECT-22890196, KAKENHI-PROJECT-23350049, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-24659411
[Journal Article] Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG2012
- Author(s)
  T. Suma, K. Miyata
- Journal Title
  
  ACS Nano
  
  Volume: 6 Issue: 8 Pages: 6693-6705
- DOI
  10.1021/nn301164a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700489, KAKENHI-PROJECT-23350049, KAKENHI-PROJECT-23390009, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-24700476
[Journal Article] Direct and Instantaneous Observation of Intravenously Injected Substances Using Intravital Confocal Micro-Videography2010
- Author(s)
  Matsumoto Y, Watanabe S, et al.
- Journal Title
  
  Biomed.Opt.Express
  
  Volume: 1 Pages: 1209-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890196
[Journal Article] Direct and Instantaneous Observation of Intravenously Injected Substances Using Intravital Confocal Micro-Videography2010
- Author(s)
  Y. Matsumoto, S. Watanabe et. al.
- Journal Title
  
  Biomed. Opt. Express
  
  Volume: 1(4) Pages: 1209-1216
- URL
  http://www.ncbi.nlm.nih.gov/pubmed?term=Direct%20and%20Instantaneous%20Observation%20of%20Intravenously%20Injected%20Substances%20Using%20Intravital%20Confocal%20Micro-Videography
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890196
[Patent] 核酸デリバリー様ユニット構造体2012
- Inventor(s)
  片岡一則、渡邉秀美代, 他6名
- Industrial Property Rights Holder
  片岡一則、渡邉秀美代, 他6名
- Filing Date
  2012-04-27
- Overseas
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] Charge number effect of block-ionomers on polygon complex formation with siRNA2015
- Author(s)
  K. Hayashi, H. Chaya, H. Takemoto, S. Fukushima, S. Watanabe, K. Osada, N. Nishiyama, K. MIyata, K. Kataoka,
- Organizer
  第64回高分子学会年次大会
- Place of Presentation
  北海道札幌市札幌イノベーションセンター
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] Enhanced blood circula/on of siRNA complexed with PEG-‐block-‐poly(L-‐lysine) for BxPC3 pancrea/c cancer therapy.2015
- Author(s)
  Sumiyo Watanabe1, 3, 4, Hiroyuki Chaya1, Takahiro Nomoto5, Shigeto Fukushima2, Kotaro Hayashi2, Kazuko Toh1, Hiroyasu Takemoto2, Xueying Liu1, Yu Matsumoto1, Shunya Uchida3, Masaomi Nangaku4, Kensuke Osada2, Nobuhiro Nishiyama5, Kanjiro Miyata1, Kazunori Kataoka1, 2
- Organizer
  The COINS International Symposium 2015.
- Place of Presentation
  The University of Tokyo, Ito Hall,Tokyo, Japan
- Year and Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] 1分子siRNA封入ユニットポリイオンコンプレックスの精密構造設計2015
- Author(s)
  宮田完二郎、林光太朗、茶谷洋行、渡邉秀美代、藤加珠子、福島重人、LAN Wanjun、KIM Hyun Jin、武元宏泰、西山伸宏、長田健介、片岡一則
- Organizer
  第64回高分子討論会
- Place of Presentation
  宮城県仙台市東北大学
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] Enhanced Blood Circulation of siRNA complexed with PEG-block-Poly(L-lysine) for BxPC3 pancreatic cancer Treatment.2014
- Author(s)
  Sumiyo Watanabe, Hiroyuki Chaya, Takahiro Nomoto, Shigeto Fukushima, Kotaro Hayashi, Kazuko Toh, Hiroyasu Takemoto, Xueying Liu, Yu Matsumoto, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Organizer
  First international symposium
- Place of Presentation
  The University of Tokyo, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] 分子siRNA 搭載ポリイオンコンプレックス(PICnanocarrier)の構築2013
- Author(s)
  林光太朗・茶谷洋行・渡邉秀美代・宮田完二郎・福島重人・長田健介・西山伸宏・片岡一則
- Organizer
  高分子討論会
- Place of Presentation
  岡山大学津島キャンパス
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] Development of single siRNA-loaded polyion complexes with PEG-b-polycations for enhanced systemic delivery of siRNA2013
- Author(s)
  Kotaro Hayashi, Hiroyuki Chaya, Sumiyo Watanabe, Shigeto Fukushima, Kazuko Toh, Yu Matsumoto, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Organizer
  US-Japan DDS symposium
- Place of Presentation
  Lahaina, Maui, Howaii
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] 分子siRNA 封入ポリイオンコンプレックスの構築～会合状態に対するPEG-ポリカチオンブロック共重合体の化学構造の効果～2013
- Author(s)
  林光太朗・福島重人・石井武彦・長田健介・片岡一則、東大院医茶谷洋行・宮田完二郎・渡邉秀美代・藤加珠子・西山伸宏
- Organizer
  高分子年次学会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] Enhanced Blood Circulation of siRNA complexed with PEG-block-Poly(L-lysine) for Cancer Treatment.2013
- Author(s)
  Sumiyo Watanabe, Hiroyuki Chaya, Takahiro Nomoto, Kotaro Hayashi, Shigeto Fukushima, Hiroyasu Takemoto, Kazuko Toh, Xueying Liu, Yu Matsumoto, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Organizer
  Controled Release Society
- Place of Presentation
  Conventional center, Honolulu, Hawaii
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] Enhanced longevity of siRNA in bloodstream by fine-tuning of PEG-block-polylysine structures.2012
- Author(s)
  Sumiyo Watanabe, Hiroyuki Chaya, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
- Organizer
  Kyoto Cell-Material Integration 2012
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] ポリカチオン構造の精密設計に基づいたポリイオンコンプレックス封入siRNA分子数の制御2012
- Author(s)
  茶谷洋行、渡邉秀美代et. al
- Organizer
  第61回高分子学会年次大会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2012-05-30
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] Preparation of polyion complexes incorporating the regulated number of siRNA molecules by fine-tuning of polycationic structures2012
- Author(s)
  Chaya H, Watanabe S, et al
- Organizer
  Softinterface International Mini-Symposium on Biointerface-Interface between Bio and Materials
- Place of Presentation
  茨城県筑波大学
- Year and Date
  2012-03-18
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] Preparation of polyion complexes incorporating the regulated number of siRNA molecules by fine-tuning of polycationic structures2012
- Author(s)
  Chaya H, Watanabe S et. al
- Organizer
  Softinterface International Mini-Symposium on Biointerface-Interface between Bio and Materials
- Place of Presentation
  つくば国際会議場、茨城県筑波市
- Year and Date
  2012-03-18
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] 糖尿病性腎症に合併した溶連菌感染後急性糸球体腎炎の一例2010
- Author(s)
  久保英二、渡邉秀美代, 他
- Organizer
  日本腎臓学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] Intravital Real-Time Confocal Microangiography2010
- Author(s)
  Matsumoto Y, Watanabe S, et al.
- Organizer
  The Third International NanoBio Conference
- Place of Presentation
  ETH Zurich, Zurich
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22890196
[Presentation] 1 分子のsiRNA からなるポリイオンコンプレックス形成挙動に対するポリアミノ酸の側鎖アルキル鎖長の効果
- Author(s)
  林光太朗・福島重人・石井武彦・長田健介・片岡一則、東大院医茶谷洋行・渡邉秀美代・宮田完二郎、西山伸宏
- Organizer
  高分子学会年次大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2014-05-28 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] ブロック共重合体の精密設計による siRNA ポリイオンコンプレックスの会合状態の制御
- Author(s)
  林光太朗・福島重人・石井武彦・長田健介・片岡一則、東大院医茶谷洋行・渡邉秀美代・宮田完二郎、西山伸宏
- Organizer
  医用高分子研究会
- Place of Presentation
  産業技術研究所
- Year and Date
  2014-07-28 – 2014-07-29
- Data Source
  KAKENHI-PROJECT-24659411
[Presentation] 1 分子のsiRNA とPEG-カチオン性ポリアミノ酸ブロック共重合体の複合体形成挙動に対する側鎖構造の影響
- Author(s)
  林光太朗・福島重人・石井武彦・長田健介・片岡一則、東大院医茶谷洋行・渡邉秀美代・宮田完二郎、西山伸宏
- Organizer
  高分子学会
- Place of Presentation
  東北大学
- Year and Date
  2014-09-15 – 2014-09-17
- Data Source
  KAKENHI-PROJECT-24659411

1. OGASAWARA Toru (20359623)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. UCHIDA Shunya (50151882)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. IKEDA Tosiyuki (80322759)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SAITO Taku (30456107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Nobuchika (90247007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HONDA Zenitiro (70238814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUKUSHIMA Shigeto (60625680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. MIYATA Kanjiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. ZHENG Meng

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 片岡一則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 武元宏泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 相田卓三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 西山伸宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATANABE Sumiyo 渡邉 秀美代

Research Projects

Research Products

Co-Researchers

siRNA carrier strategy to inhibit to rejection of transplanted kidneysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Does the podocyte damage is non-invertible? Inquest therapeutic modality for the damage.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Where is the cause of Bartter's syndrome in the kidney?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 症候群ハンドブック2011

Author(s)

Total Pages

Publisher

Data Source

[Book] 症候群ハンドブック2011

Author(s)

Publisher

Data Source

[Book] 症候群ハンドブック2011

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Influence of RNA strand rigidity on polyion complex formation with block catiomers.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional activities of mutant calcium-sensing receptors determine clinical presentations in patients with autosomal dominant hypocalcemia.2014

Author(s)

Journal Title

Data Source

[Journal Article] Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ニコランジル 慢性腎不全モデルラットでのポドサイトとマクロファージをターゲットとした新しい治療薬(2013

Author(s)

Journal Title

Data Source

[Journal Article] 常染色体優性低カルシウム(Ca)血症(ADH)の臨床的重症度と生化学的指標の関係2013

Author(s)

Journal Title

Data Source

[Journal Article] Biomolecular Robotics for Chemomechanically Driven Guest Delivery Fuelled by Intracellular ATP2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct and Instantaneous Observation of Intravenously Injected Substances Using Intravital Confocal Micro-Videography2010

Author(s)

WATANABE Sumiyo 渡邉秀美代

[Journal Article] ニコランジル　慢性腎不全モデルラットでのポドサイトとマクロファージをターゲットとした新しい治療薬(2013

[Presentation] Enhanced blood circula/on of siRNA complexed with PEG-‐block-‐poly(L-‐lysine) for BxPC3 pancrea/c cancer therapy.2015

[Presentation] 分子siRNA 封入ポリイオンコンプレックスの構築～会合状態に対するPEG-ポリカチオンブロック共重合体の化学構造の効果～2013