HIKOSO SHUNGO 彦惣俊吾

… Alternative Names

HIKOSO Shungo 彦惣俊吾

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Researcher Number	30423164
Other IDs
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Affiliation (Current)	2023: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2021: 大阪大学, 医学系研究科, 准教授 2015 – 2017: 大阪大学, 医学系研究科, 寄附講座准教授 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 2014: 大阪大学, 医学(系)研究科(研究院), 寄付講座准教授 2013: 大阪大学, 医学部附属病院, 特任准教授(常勤) … More 2012: 大阪大学, 医学(系)研究科(研究院), 招聘教員 2011: 大阪大学, 医学系研究科, 招へい教員 2011: 大阪大学, 大学院・医学系研究科, 助教 2010 – 2011: 大阪大学, 医学系研究科, 助教 2008 – 2009: Osaka University, 保健センター, 助教 2006 – 2007: 大阪大学, 医学系研究科, 特任研究員 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心不全 / 分子心臓病態学 / iPS細胞 / サイトカイン / 蛋白分解 / カルパイン / アポトーシス / タンパク分解系 / 炎症反応 / ミトコンドリアDNA … More / 炎症 / ミトコンドリア / DNase II / 遺伝子改変マウス / 拡張型心筋症 / デスモゾーム / 病態モデル / 心筋症 / 細胞間接着 / 循環器内科学 … More Except Principal Investigator 心不全 / ゲノム編集 / オートファジー / 疾患iPS細胞 / 細胞死 / ミトコンドリア / 心筋症 / ネクローシス / アポトーシス / 細胞内分解系 / 心筋細胞死 / 拡張型心筋症 / 心筋細胞 / 相同組み換え / 循環器 / 左室収縮能が保たれた心不全 / 左室収縮能が保たれた / バイオマーカー / 循環器・高血圧 / 内科 / 心肥大 / 逆リモデリング / ミトコンドリアダイナミクス / 難治性心筋症 / 肥大型心筋症 / 不整脈原性心筋症 / iPS細胞 / 遺伝子治療 / 不整脈源性右室心筋症 Less

Development of Human Disease Model of Arrhythmogenic Right Ventricular Cardiomyopathy for Personalized Medicine
- Principal Investigator
  
  Sakata Yasushi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Therapeutic development targeting molecular basis of dilated-phase hypertrophic cardiomyopathy
- Principal Investigator
  
  Higo Shuichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Clarification of molecular pathophysiology and identification of therapeutic target in desmosome-related cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  Hikoso Shungo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Development of upstream therapy targeting molecular basis of refractory cardiomyopathy
- Principal Investigator
  
  Sakata Yasushi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Usefulness of risk stratification of the patients with heart failure with preserved ejection fraction by multiple biomarkers
- Principal Investigator
  
  Suna Shinichiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Therapeutic Application of Genome Editing for Advanced Heart Failure
- Principal Investigator
  
  Shuichiro Higo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Integrated analyses of mitochondria degradation system as a novel therapeutic target of heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Regulatory mechanism of mitochondria dynamics during progression of cardiac reverse remodeling
- Principal Investigator
  
  Yamaguchi Osamu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Clarification of the role of regulatory mechanism of mitochondria DNA in heart and the application to treatment of heart failurePrincipal Investigator
- Principal Investigator
  
  Hikoso Shungo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Elucidation of mechanism of chronic inflammation originated from mitochondria, and the application for the treatment of heart failurePrincipal Investigator
- Principal Investigator
  
  HIKOSO Shungo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of intracellular degradation systems in genesis of heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The investigation of the role of protein degradation pathway during progression to heart failure, and the application to heart failure treatment.Principal Investigator
- Principal Investigator
  
  HIKOSO Shungo
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Elucidation of molecular mechanisms underlying cell death in heart failure
- Principal Investigator
  
  OTSU Kinya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心筋TNF-αの産生制御機構の心不全発症における役割の解明と治療への応用Principal Investigator
- Principal Investigator
  
  彦惣俊吾
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

[Journal Article] Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes2022
- Author(s)
  Inoue Hiroyuki、Nakamura Satoki、Higo Shuichiro、Shiba Mikio、Kohama Yasuaki、Kondo Takumi、Kameda Satoshi、Tabata Tomoka、Okuno Shota、Ikeda Yoshihiko、Li Junjun、Liu Li、Yamazaki Satoru、Takeda Maki、Ito Emiko、Takashima Seiji、Miyagawa Shigeru、Sawa Yoshiki、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Pages: 337-351
- DOI
  10.1016/j.stemcr.2021.12.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-21H02915
[Journal Article] Phospholamban p.Arg14del Cardiomyopathy: A Japanese Case Series2022
- Author(s)
  Tabata Tomoka、Kuramoto Yuki、Ohtani Tomohito、Miyawaki Hiroshi、Miyashita Yohei、Sera Fusako、Kioka Hidetaka、Higo Shuichiro、Asano Yoshihiro、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  Internal Medicine
  
  Volume: - Issue: 13 Pages: 1987-1993
- DOI
  10.2169/internalmedicine.8594-21
- NAID
  130008130223
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-21H02915
[Journal Article] Genome Editing in Human Induced Pluripotent Stem Cells (hiPSCs)2021
- Author(s)
  Higo Shuichiro、Hikoso Shungo、Miyagawa Shigeru、Sakata Yasushi
- Journal Title
  
  Methods Mol Biol
  
  Volume: - Pages: 235-245
- DOI
  10.1007/978-1-0716-1484-6_21
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-21H02915
[Journal Article] Phenotypic recapitulation and correction of desmoglein-2-deficient cardiomyopathy using human-induced pluripotent stem cell-derived cardiomyocytes2021
- Author(s)
  Shiba Mikio、Higo Shuichiro、Kondo Takumi、Li Junjun、Liu Li、Ikeda Yoshihiko、Kohama Yasuaki、Kameda Satoshi、Tabata Tomoka、Inoue Hiroyuki、Nakamura Satoki、Takeda Maki、Ito Emiko、Takashima Seiji、Miyagawa Shigeru、Sawa Yoshiki、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30 Pages: 1384-1397
- DOI
  10.1093/hmg/ddab127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-21H02915
[Journal Article] Impact of Hyperglycemia on Long-Term Outcome in Patients With ST-Segment Elevation Myocardial Infarction2020
- Author(s)
  Kojima Takayuki、Hikoso Shungo、Nakatani Daisaku、Suna Shinichiro、Dohi Tomoharu、Mizuno Hiroya、Okada Katsuki、Kitamura Tetsuhisa、Kida Hirota、Oeun Bolrathanak、Sunaga Akihiro、Kurakami Hiroyuki、Yamada Tomomi、Sakata Yasuhiko、Sato Hiroshi、Hori Masatsugu、Komuro Issei、Sakata Yasushi
- Journal Title
  
  The American Journal of Cardiology
  
  Volume: 125 Pages: 851-859
- DOI
  10.1016/j.amjcard.2019.12.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19543
[Journal Article] Considerable Scatter in the Relationship Between Left Atrial Volume and Pressure in Heart Failure With Preserved Left Ventricular Ejection Fraction2020
- Author(s)
  Shiro Hoshida, Tetsuya Watanabe, Yukinori Shinoda, Tomoko Minamisaka, Hidetada Fukuoka, Hirooki Inui, Keisuke Ueno, Takahisa Yamada, Masaaki Uematsu, Yoshio Yasumura, Daisaku Nakatani, Shinichiro Suna, Shungo Hikoso, Yoshiharu Higuchi, Yasushi Sakata, Osaka CardioVascular Conference (OCVC) Investigators
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 90-90
- DOI
  10.1038/s41598-019-56581-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09496
[Journal Article] Long-term Effects of the Janus Kinase 1/2 Inhibitor Ruxolitinib on Pulmonary Hypertension and the Cardiac Function in a Patient with Myelofibrosis2020
- Author(s)
  Miyawaki H, Kioka H, Sato K, Kurashige M, Ozawa T, Shibayama H, Hikoso S, Morii E, Yamauchi-Takihara K, Sakata Y.
- Journal Title
  
  Internal Medicine
  
  Volume: 59 Issue: 2 Pages: 229-233
- DOI
  10.2169/internalmedicine.3528-19
- NAID
  130007785096
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-18K19543, KAKENHI-PROJECT-19K16585
[Journal Article] Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes2020
- Author(s)
  Kohama Yasuaki、Higo Shuichiro、Masumura Yuki、Shiba Mikio、Kondo Takumi、Ishizu Takamaru、Higo Tomoaki、Nakamura Satoki、Kameda Satoshi、Tabata Tomoka、Inoue Hiroyuki、Motooka Daisuke、Okuzaki Daisuke、Takashima Seiji、Miyagawa Shigeru、Sawa Yoshiki、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 15348-15348
- DOI
  10.1038/s41598-020-72216-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-20K08356, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-18K08069, KAKENHI-PROJECT-19K16518
[Journal Article] Old-Age Onset Progressive Cardiac Contractile Dysfunction in a Patient with Polycystic Kidney Disease Harboring a <i>PKD1</i> Frameshift Mutation2019
- Author(s)
  Suwa Yoshinobu、Higo Shuichiro、Nakamoto Kei、Sera Fusako、Kunimatsu Suzuka、Masumura Yuki、Kanzaki Machiko、Mizote Isamu、Mizuno Hiroya、Fujio Yasushi、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  International Heart Journal
  
  Volume: 60 Issue: 1 Pages: 220-225
- DOI
  10.1536/ihj.18-184
- NAID
  130007557187
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19543, KAKENHI-PROJECT-18K19545, KAKENHI-PROJECT-18K15848, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-17K16004
[Journal Article] Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction2019
- Author(s)
  Shibamoto Masato、Higo Tomoaki、Naito Atsuhiko T.、Nakagawa Akito、Sumida Tomokazu、Okada Katsuki、Sakai Taku、Kuramoto Yuki、Yamaguchi Toshihiro、Ito Masamichi、Masumura Yuki、Higo Shuichirou、Lee Jong-Kook、Hikoso Shungo、Komuro Issei、Sakata Yasushi
- Journal Title
  
  International Heart Journal
  
  Volume: 60 Issue: 4 Pages: 944-957
- DOI
  10.1536/ihj.18-701
- NAID
  130007684141
- ISSN
  1349-2365, 1349-3299
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03662, KAKENHI-PROJECT-18K19543, KAKENHI-PROJECT-19K08489
[Journal Article] Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes2017
- Author(s)
  Ishizu T, Higo S, Masumura Y, Kohama Y, Shiba M, Higo T, Shibamoto M, Nakagawa A, Morimoto S, Takashima S, Hikoso S, Sakata Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 9363-9363
- DOI
  10.1038/s41598-017-09716-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-17K16004, KAKENHI-PROJECT-15H04820
[Journal Article] Clinical Impact of Ventricular Tachycardia and/or Fibrillation During the Acute Phase of Acute Myocardial Infarction on In-Hospital and 5-Year Mortality Rates in the Percutaneous Coronary Intervention Era2016
- Author(s)
  3.Masuda M, Nakatani D, Hikoso S, Suna S, Usami M, Matsumoto S, Kitamura T, Minamiguchi H, Okuyama Y, Uematsu M, Yamada T, Iwakura K, Hamasaki T, Sakata Y, Sato H, Nanto S, Hori M, Komuro I, Sakata Y
- Journal Title
  
  Circulation Journal
  
  Volume: 80 Issue: 7 Pages: 1539-1547
- DOI
  10.1253/circj.cj-16-0183
  10.1253/circj.CJ-16-0183
- NAID
  130005158910
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461129
[Journal Article] Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation2015
- Author(s)
  Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Pages: 7527-7527
- DOI
  10.1038/ncomms8527
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09140, KAKENHI-PROJECT-26461129, KAKENHI-PUBLICLY-15H01536, KAKENHI-PUBLICLY-26111513, KAKENHI-PROJECT-15H04822, KAKENHI-PROJECT-25650067, KAKENHI-PROJECT-25291045, KAKENHI-PROJECT-25713031
[Journal Article] Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading.2013
- Author(s)
  Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, Taneike M, Omiya S, Shah AM, Nishida K, Otsu K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 441 Pages: 767-792
- DOI
  10.1016/j.bbrc.2013.10.135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390212, KAKENHI-PROJECT-23689042, KAKENHI-PROJECT-25713031
[Journal Article] Rheb (Ras Homologue Enriched in Brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.2013
- Author(s)
  Tamai T, Komuro I (17人中16番目）
- Journal Title
  
  Journal of the Biological Chemistry.
  
  Volume: 288 Pages: 10176-10187
- DOI
  10.1074/jbc.m112.423640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-23689042
[Journal Article] Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading2013
- Author(s)
  Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, Taneike M, Omiya S, Shah AM, Nishida K, Otsu K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441(4) Pages: 787-92
- Data Source
  KAKENHI-PROJECT-23689042
[Journal Article] Rheb (Ras Homologue Enriched in Brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period2013
- Author(s)
  Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro I, Otsu K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288(14) Pages: 10176-87
- Data Source
  KAKENHI-PROJECT-23689042
[Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure2012
- Author(s)
  Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K.
- Journal Title
  
  Nature(Erratum in : Nature. 2012 Oct 11;490(7419):292)
  
  Volume: 485(7397) Pages: 251-5
- Data Source
  KAKENHI-PROJECT-23689042
[Journal Article] Mitochondrial DNA that escapes from autophagy induces inflammation and heart failure2012
- Author(s)
  Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K
- Journal Title
  
  nature
  
  Volume: 485 Pages: 251-255
- DOI
  10.1038/nature10992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-21390240, KAKENHI-PROJECT-23689042, KAKENHI-PROJECT-23790850
[Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure2012
- Author(s)
  岡崇史、彦惣俊吾、山口修、種池学、武田理宏、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、審良静男、山本章次、小室一成、大津欣也
- Journal Title
  
  Nature
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  種池学、彦惣俊吾, その他
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 32170-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689042
[Journal Article] Calpain protects the heart from hemodynamic stress2011
- Author(s)
  種池学、溝手勇、森田孝、渡部徹也、彦惣俊吾、山口修、武田理宏、岡崇史、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、竹田潤二、望月直樹、小室一成、大津欣也
- Journal Title
  
  The Journal of Biological Chemistory
  
  Volume: 286 Pages: 32170-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy2010
- Author(s)
  種池学、山口修、中井敦子、彦惣俊吾、武田理宏、溝手勇、岡崇史、玉井敬人、大藪丈太、村川智一、西田和彦、清水孝彦、堀正二、小室一成、白澤卓司、水島昇、大津欣也
- Journal Title
  
  Autophagy
  
  Volume: 6 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure2010
- Author(s)
  I Mizote, O Yamaguchi, S Hikoso, T Takeda, M Taneike, T Oka, T Tamai, J Oyabu, Y Matsumura, K Nishida, I Komuro, M Hori, K Otsu
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 48
  
  Pages: 302-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] The I B kinase /NF- B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of MnSOD expression2009
- Author(s)
  S Hikoso, O Yamaguchi, Y Nakano, T Takeda, S Omiya, I Mizote, M Taneike, T Oka, T Tamai, J Oyabu, Y Uno, Y Matsumura, K Nishida, K Suzuki, M Kogo, M Hori, K Otsu
- Journal Title
  
  Circulation Research 105
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the proression to heart failure2009
- Author(s)
  T Ohtani, T Mano, S Hikoso, Y Sakata, M Nishio, Y Takeda, K Otsu, T Miwa, T Masuyama, M Hori, K Yamamoto
- Journal Title
  
  Journal of Hypertensions 27
  
  Pages: 1074-1083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2009
- Author(s)
  Shigemiki Omiya, Shungo Hikoso, Yukiko Imanishi, Atsuhiro Saito, Osamu Yamaguchi, Toshihiro Takeda, Isamu Mizote, Takafumi Oka, Manabu Taneike, Yuko Nakano, Yasushi Matsumura, Kazuhiko Nishida, Yoshiki Sawa, Masatsugu Hori, Kinya Otsu
- Journal Title
  
  J. Mol. Cell. Cardiol 46
  
  Pages: 59-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] The IκB kinase β/NF-κB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of MnSOD expression2009
- Author(s)
  Shungo Hikoso, 他
- Journal Title
  
  Circulation Research 105
  
  Pages: 70-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2009
- Author(s)
  S Omiya, S Hikoso, Y Imanishi, A Saito, O Yamaguchi, T Takeda, I Mizote, T Oka, M Taniike, Y Nakano, Y Matsumura, K Nishida, Y Sawa, M Hori, K Otsu
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 46
  
  Pages: 59-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] The IκB kinase β/NF-κB signaling pathway protects the heart from hemodynamic stress mediated through the regulation of MnSOD expression2009
- Author(s)
  彦惣俊吾, ほか
- Journal Title
  
  Circulation Research 105
  
  Pages: 70-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390240
[Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008
- Author(s)
  Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, PhD, Masayuki Taniike, Isamu Mizote, Yasushi Matsumura, Takahiko Shimizu, Kazuhiko Nishida, Kiyohiro Imai, Masatsugu Hori, Takuji Shirasawa, Kinya Otsu
- Journal Title
  
  J. Am. Coll. Cardiol. 52
  
  Pages: 779-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008
- Author(s)
  T Watanabe, T Takeda, S Omiya, S Hikoso, O Yamaguchi, Y Nakano, Y Higuchi, A Nakai, Y Abe, Y Aki-Jin, M Taniike, I Mizote, Y Matsumura, T Shimizu, K Nishida, K Imai, M Hori, T Shirasawa, K Otsu
- Journal Title
  
  Journal of the American College of Cardiology 52
  
  Pages: 779-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy2008
- Author(s)
  M Taniike, O Yamaguchi, I Tsujimoto, S Hikoso, T Takeda, A Nakai, S Omiya, I Mizote, Y Nakano, Y Higuchi, Y Matsumura, K Nishida, H Ichijo, M Hori, K Otsu
- Journal Title
  
  Circulation 117
  
  Pages: 545-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790529
[Journal Article] Apoptosis signal-regulating kinase 1(ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy2008
- Author(s)
  Masayuki Taniike, Osamu Yamaguchi, Ikuko Tsujimoto, Shungo Hikoso, Toshihiro Takeda, Atsuko Nakai, Shigemiki Omiya, Isamu Mizote, Yuko Nakano, Yoshiharu Higuchi, Yasushi Matsumura, Kazuhiro Nishida, Masatsugu Hori, Hidenori Ichijo, Kinya Otsu
- Journal Title
  
  Circulation 117
  
  Pages: 545-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Apoptosis Signal-Regulating Kinase l/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy2008
- Author(s)
  谷池正行、山口修、辻本育子、彦惣俊吾、その他
- Journal Title
  
  Circulation 117
  
  Pages: 545-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790498
[Journal Article] The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress2007
- Author(s)
  Atsuko Nakai, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shungo Hikoso, Masayuki Taniike, Shigemiki Omiya, Isamu Mizote, Yasushi Matsumura, Michio Asahi, Kazuhiko Nishida, Masatsugu Hori, Noboru Mizushima, Kinya Otsu
- Journal Title
  
  Nature Medicine 13
  
  Pages: 619-624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Progression of Heart Failure was Suppressed by Inhibition of Apoptosis Signal-regulating Kinase 1 (ASK1) via Transcoronary Gene Transfer2007
- Author(s)
  Hikoso, et. al.
- Journal Title
  
  J. Am. Coll. Cardiol. 50
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer2007
- Author(s)
  Shungo Hikoso, Yasuhiro Ikeda, Osamu Yamaguchi, Toshihiro Takeda, Yoshiharu Higuchi, Shinichi Hirotani, Kazunori Kashiwase, Michio Yamada, Michio Asahi, Yasushi Matsumura, Kazuhiko Nishida, Masunori Matsuzaki, Masatsugu Hori, Kinya Otsu
- Journal Title
  
  J. Am. Coll. Cardiol 50
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390214
[Journal Article] Progression of heart failture was suppressed by inhibition of apoptosis signal-regvdating kinase 1 (ASKl) via transcoronary gene transfer.2007
- Author(s)
  彦惣俊吾、その他
- Journal Title
  
  Journal of the American College of Cardiology 50
  
  Pages: 453-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790498
[Journal Article] 酸化ストレスと心筋細胞障害2007
- Author(s)
  彦惣俊吾、大津欣也、堀正二
- Journal Title
  
  Cardiac Practice 18
  
  Pages: 351-354
- Data Source
  KAKENHI-PROJECT-18790498
[Journal Article] あらたな心不全治療標的としての心筋細胞死制御にかかわる細胞内シグナル伝達機構2006
- Author(s)
  彦惣俊吾, 大津欣也
- Journal Title
  
  医学のあゆみ 218・14
  
  Pages: 1327-1327
- Data Source
  KAKENHI-PROJECT-18790498
[Patent] 不整脈源性心筋症患者由来の多能性幹細胞およびその利用ならびに不整脈源性心筋症治療用医薬2020
- Inventor(s)
  肥後修一朗, 彦惣俊吾, 宮川繁, 澤芳樹, 坂田泰史
- Industrial Property Rights Holder
  肥後修一朗, 彦惣俊吾, 宮川繁, 澤芳樹, 坂田泰史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-044996
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K08489
[Patent] 不整脈源性心筋症患者由来の多能性幹細胞およびその利用ならびに不整脈源性心筋症治療用医薬2020
- Inventor(s)
  肥後修一朗, 彦惣俊吾, 宮川繁, 澤芳樹, 坂田泰史
- Industrial Property Rights Holder
  肥後修一朗, 彦惣俊吾, 宮川繁, 澤芳樹, 坂田泰史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-044996
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Modeling Reduced Contractility and Impaired Desmosome Assembly due to Plakophilin-2 Deficiency using Isogenic iPS Cell-Derived Cardiomyocytes2022
- Author(s)
  Hiroyuki Inoue,Satoki Nakamura,Shuichiro Higo,Mikio Shiba,Yasuaki Kohama,Takumi Kondo,Satoshi Kameda,Tomoka Tabata,Shota Okuno,Yoshihiko Ikeda,Junjun Li,Li Liu,Satoru Yamazaki,Maki Takeda,Emiko Ito,Seiji Takashima,Shigeru Miyagwa,Sawa Yoshiki,Shungo Hikoso,Yasushi Sakata
- Organizer
  第86回日本循環器学会学術集会 YIA (Basic Research部門）優秀賞
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Modeling Reduced Contractility and Impaired Desmosome Assembly due to Plakophilin-2 Deficiency using Isogenic iPS Cell-Derived Cardiomyocytes2022
- Author(s)
  Hiroyuki Inoue,Satoki Nakamura,Shuichiro Higo,Mikio Shiba,Yasuaki Kohama,Takumi Kondo,Satoshi Kameda,Tomoka Tabata,Shota Okuno,Yoshihiko Ikeda,Junjun Li,Li Liu,Satoru Yamazaki,Maki Takeda,Emiko Ito,Seiji Takashima,Shigeru Miyagwa,Sawa Yoshiki,Shungo Hikoso,Yasushi Sakata
- Organizer
  第86回日本循環器学会学術集会 YIA (Basic Research部門）優秀賞
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] トロポニンTΔ160E変異を有するアイソジェニックiPS心筋を用いた拡張相肥大型心筋症の病態解明2021
- Author(s)
  近藤匠巳,肥後修一朗,志波幹夫,小濱康明,亀田聡士,田端智香,井上裕之,奥野翔太,武田真季,藏本勇希,李鍾國,高島成二,宮川繁,彦惣俊吾,坂田泰史
- Organizer
  第7回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] トロポニンTΔ160E変異を有するアイソジェニックiPS心筋を用いた拡張相肥大型心筋症の病態解明2021
- Author(s)
  近藤匠巳,肥後修一朗,志波幹夫,小濱康明,亀田聡士,田端智香,井上裕之,奥野翔太,武田真季,藏本勇希,李鍾國,高島成二,宮川繁,彦惣俊吾,坂田泰史
- Organizer
  第7回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Modeling Augmented Sarcomeric Calcium Retention and Altered Calcium Handling Pathway by TNNT2 Δ160E Mutation using Isogenic Human iPS Cell-derived Cardiomyocytes2021
- Author(s)
  Takumi Kondo,Shuichiro Higo,Mikio Shiba,Yasuaki Kohama,Satoshi Kameda,Tomoka Tabata,Hiroyuki Inoue,Shota Okuno,Maki Takeda,Yuki Kuramoto,Jong-Kook Lee,Seiji Takashima,Shigeru Miyagawa,Shungo Hikoso,Yasushi Sakata
- Organizer
  第25回日本心不全学会学術集会YIA基礎部門優秀賞
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] 悪性心室性頻拍と重症心不全を特徴とする日本におけるホスホランバン p.Arg14del心筋症の臨床像2021
- Author(s)
  田端智香,藏本勇希,大谷朋仁,宮脇大,宮下洋平,世良英子,木岡秀隆,肥後修一朗,朝野仁裕,彦惣俊吾,坂田泰史
- Organizer
  第25回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Modeling Augmented Sarcomeric Calcium Retention and Altered Calcium Handling Pathway by TNNT2 Δ160E Mutation using Isogenic Human iPS Cell-derived Cardiomyocytes2021
- Author(s)
  Takumi Kondo,Shuichiro Higo,Mikio Shiba,Yasuaki Kohama,Satoshi Kameda,Tomoka Tabata,Hiroyuki Inoue,Shota Okuno,Maki Takeda,Yuki Kuramoto,Jong-Kook Lee,Seiji Takashima,Shigeru Miyagawa,Shungo Hikoso,Yasushi Sakata
- Organizer
  第25回日本心不全学会学術集会YIA基礎部門優秀賞
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Development of Precision Medicine for Arrhythmogenic Cardiomyopathy using Isogenic Human Disease Model2021
- Author(s)
  Shuichiro Higo,Shungo Hikoso,Yasushi Sakata
- Organizer
  第85日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Development of Precision Medicine for Arrhythmogenic Cardiomyopathy using Isogenic Human Disease Model2021
- Author(s)
  Shuichiro Higo,Shungo Hikoso,Yasushi Sakata
- Organizer
  第85日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] The Role and Mechanism of Chronic Inflammation in the Pathogenesis of Heart Failure with Preserved Ejection Fraction (HFpEF)2021
- Author(s)
  彦惣俊吾
- Organizer
  第84回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] Development of Precision Medicine for Arrhythmogenic Cardiomyopathy using Isogenic Human Disease Model2021
- Author(s)
  Shuichiro Higo,Shungo Hikoso,Yasushi Sakata
- Organizer
  第85日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] 悪性心室性頻拍と重症心不全を特徴とする日本におけるホスホランバン p.Arg14del心筋症の臨床像2021
- Author(s)
  田端智香,藏本勇希,大谷朋仁,宮脇大,宮下洋平,世良英子,木岡秀隆,肥後修一朗,朝野仁裕,彦惣俊吾,坂田泰史
- Organizer
  第25回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cellderived Cardiomyocytes2020
- Author(s)
  志波幹夫,肥後修一朗,近藤匠巳,李俊君,劉莉,小濱康明,亀田聡士,田端智香,井上裕之,中村聡希,武田真季,池田善彦,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第68回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Adeno-associated Virus-mediated Gene Delivery Promotes S-Phase Entry-independent Homology-directed Repair in Cardiomyocytes2020
- Author(s)
  Yasuaki Kohama,Shuichiro Higo,Mikio Shiba,Takumi Kondo,Satoki Nakamura,Satoshi Kameda,Tomoka Tabata,Hiroyuki Inoue,Seiji Takashima,Shigeru Miyagawa,Yoshiki Sawa,Shungo Hikoso,Yasushi Sakata
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] 不整脈源性右室心筋症（ARVC）を迅速に再現するヒトモデル細胞の樹立2020
- Author(s)
  中村聡希,肥後修一朗,志波幹夫,小濱康明,近藤匠巳,亀田聡士,田端智香,井上裕之,山崎悟,武田真季,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第6回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] ハイコンテントイメージング・数値計算ソフトウェアを用いた心筋症iPS 分化心筋におけるカルシウム動態解析2020
- Author(s)
  田端智香,肥後修一朗,増村雄喜,志波幹夫,小濱康明,近藤匠巳,亀田聡士,井上裕之,中村聡希,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第6回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Generation of Human Disease Model for Personalized Medicine Targeting Intractable Cardiomyopathy2020
- Author(s)
  Shuichiro Higo, Shungo Hikoso, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会 ESC-JCS Young Researchers Session
- Invited
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Adeno-associated Virus-mediated Gene Delivery Promotes S-Phase Entry-independent Homology-directed Repair in Cardiomyocytes2020
- Author(s)
  Yasuaki Kohama,Shuichiro Higo,Mikio Shiba,Takumi Kondo,Satoki Nakamura,Satoshi Kameda,Tomoka Tabata,Hiroyuki Inoue,Seiji Takashima,Shigeru Miyagawa,Yoshiki Sawa,Shungo Hikoso,Yasushi Sakata
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] ハイコンテントイメージング・数値計算ソフトウェアを用いた心筋症iPS 分化心筋におけるカルシウム動態解析2020
- Author(s)
  田端智香,肥後修一朗,増村雄喜,志波幹夫,小濱康明,近藤匠巳,亀田聡士,井上裕之,中村聡希,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第6回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cellderived Cardiomyocytes2020
- Author(s)
  志波幹夫,肥後修一朗,近藤匠巳,李俊君,劉莉,小濱康明,亀田聡士,田端智香,井上裕之,中村聡希,武田真季,池田善彦,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第68回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Drug discovery for cardiomyopathies using disease-specific iPDCs2020
- Author(s)
  Shuichiro Higo, Shungo Hikoso, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] Adeno-associated Virus-mediated Gene Delivery Promotes S-Phase Entry-independent Homology-directed Repair in Cardiomyocytes2020
- Author(s)
  Yasuaki Kohama,Shuichiro Higo,Mikio Shiba,Takumi Kondo,Satoki Nakamura,Satoshi Kameda,Tomoka Tabata,Hiroyuki Inoue,Seiji Takashima,Shigeru Miyagawa,Yoshiki Sawa,Shungo Hikoso,Yasushi Sakata
- Organizer
  第24回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] Phenotypic Recapitulation and Correction of Desmoglein-2-deficient Cardiomyopathy using Human Induced Pluripotent Stem Cellderived Cardiomyocytes2020
- Author(s)
  志波幹夫,肥後修一朗,近藤匠巳,李俊君,劉莉,小濱康明,亀田聡士,田端智香,井上裕之,中村聡希,武田真季,池田善彦,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第68回日本心臓病学会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] 不整脈源性右室心筋症（ARVC）を迅速に再現するヒトモデル細胞の樹立2020
- Author(s)
  中村聡希,肥後修一朗,志波幹夫,小濱康明,近藤匠巳,亀田聡士,田端智香,井上裕之,山崎悟,武田真季,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第6回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Drug discovery for cardiomyopathies using disease-specific iPSCs2020
- Author(s)
  Shuichiro Higo,Shungo Hikoso,Shigeru Miyagawa,Yoshiki Sawa,Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会 Modelling Cardiovascular Disease with Human iPS Cells: Current Status and Future Prospects
- Invited
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Generation of Human Disease Model for Personalized Medicine Targeting Intractable Cardiomyopathy2020
- Author(s)
  Shuichiro Higo, Shungo Hikoso, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] 不整脈源性右室心筋症（ARVC）を迅速に再現するヒトモデル細胞の樹立2020
- Author(s)
  中村聡希,肥後修一朗,志波幹夫,小濱康明,近藤匠巳,亀田聡士,田端智香,井上裕之,山崎悟,武田真季,高島成二,宮川繁,澤芳樹,彦惣俊吾,坂田泰史
- Organizer
  第6回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] Generation of Human Disease Model for Personalized Medicine Targeting Intractable Cardiomyopathy2020
- Author(s)
  Shuichiro Higo, Shungo Hikoso, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会 ESC-JCS Young Researchers Session
- Invited
- Data Source
  KAKENHI-PROJECT-20K21602
[Presentation] Drug discovery for cardiomyopathies using disease-specific iPSCs2020
- Author(s)
  Shuichiro Higo,Shungo Hikoso,Shigeru Miyagawa,Yoshiki Sawa,Yasushi Sakata
- Organizer
  第84回日本循環器学会学術集会 Modelling Cardiovascular Disease with Human iPS Cells: Current Status and Future Prospects
- Invited
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Generation of Human Disease Model for Personalized Medicine Targeting Intractable Cardiomyopathy2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shigeru Miyagawa, Shungo Hikoso and Yasushi Sakata
- Organizer
  第36回 ISHR（国際心臓研究学会日本部会）
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] High-content Image Analysis Combined with Genome Editing Clarifies the Role for Pkd1 as a Sarcoplasmic Reticulum Protein that Regulates Calcium Influx in Cardiomyocytes2019
- Author(s)
  Yuki Masumura, Shuichiro Higo, Takamaru Ishizu, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Satoshi Kameda, Hiroyuki Inoue, Tomoka Tabata, Satoki Nakamura, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  第3回BCVR
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Therapeutic and Diagnostic Application of Genome Editing for Advanced Heart2019
- Author(s)
  Takamaru Ishizu, Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第3回BCVR
- Invited
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Generation of Human Disease Model for Personalized Medicine Targeting Intractable Cardiomyopathy2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shigeru Miyagawa, Shungo Hikoso and Yasushi Sakata
- Organizer
  第36回 ISHR（国際心臓研究学会日本部会）
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Medical Application of Genome Editing for Advanced Heart Failure2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第83回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] High-content Image Analysis Combined with Genome Editing Clarifies the Role for Pkd1 as a Sarcoplasmic Reticulum Protein that Regulates Calcium Influx in Cardiomyocytes2019
- Author(s)
  Yuki Masumura, Shuichiro Higo, Takamaru Ishizu, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Satoshi Kameda, Hiroyuki Inoue, Tomoka Tabata, Satoki Nakamura, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  第3回BCVR
- Data Source
  KAKENHI-PROJECT-19K08489
[Presentation] Therapeutic and Diagnostic Application of Genome Editing for Advanced Heart2019
- Author(s)
  Takamaru Ishizu, Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第3回BCVR
- Invited
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Medical Application of Genome Editing for Advanced Heart Failure2019
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  第83回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes2018
- Author(s)
  Takamaru Ishizu, Shuichiro Higo, Shungo Hikoso, Yasushi Sakata
- Organizer
  第1回日本循環器学会基礎研究フォーラム　基礎研究助成講演
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Dilated Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo Hikoso Shungo, Sakata Yasushi
- Organizer
  第9回武田科学振興財団薬科学シンポジウム医薬応用を目指したゲノム編集
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ゲノム編集の重症心不全医療応用2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] 高齢期において進行性難治性心不全を呈しPKD1フレームシフト変異が同定された多発性嚢胞腎の1例2018
- Author(s)
  宮崎友希, 肥後修一朗, 諏訪恵信, 中本敬, 世良英子, 溝手勇, 水野裕八, 藤尾慈, 彦惣俊吾, 坂田泰史
- Organizer
  医学生研修医の日本内科学会ことはじめ2018京都
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation2018
- Author(s)
  Yuki Masumura, Shuichiro Higo, Shungo Hikoso, Seiji Takashima, Yasushi Sakata
- Organizer
  第2回BCVR
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Rapid Evaluation of Candidate Causal Gene Mutation using High-content Image Analysis Combined with Targeted Gene Disruption2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Masato Shibamoto, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation2018
- Author(s)
  Yuki Masumura, Shuichiro Higo, Shungo Hikoso, Seiji Takashima, Yasushi Sakata
- Organizer
  第2回BCVR
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ゲノム編集の重症心不全医療応用2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Genome Editing in Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  European Society of Cardiology Congress 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Multiplexed Measurement of Cell-type Specific Calcium Dynamics Using High-content Image Analysis2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Takamaru Ishizu, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Tomoaki Higo, Masato Shibamoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ハイコンテントイメージ解析及びゲノム編集を用いた心筋症遺伝子変異の病原性の迅速な評価系の構築2018
- Author(s)
  増村雄喜、國松鈴花、肥後修一朗、小濱康明、志波幹夫、近藤匠巳、肥後友彰、柴本将人、高島成二、宮川繁、彦惣俊吾、坂田泰史
- Organizer
  第3回心筋症研究会 YIA
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 二度の心停止から蘇生されプラコフィリン2(PKP2)ハプロ不全が同定された不整脈源性右室心筋症(ARVC)の一例2018
- Author(s)
  中村聡希, 肥後修一朗, 南口仁, 世良英子, 水野裕八國松鈴花, 志波幹夫, 高島成二, 彦惣俊吾, 坂田泰史
- Organizer
  第221回日本内科学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Genome Editing in Cardiomyopathy2018
- Author(s)
  Shuichiro Higo, Yuki Masumura, Shungo Hikoso, Yasushi Sakata
- Organizer
  European Society of Cardiology Congress 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] 二度の心停止から蘇生されプラコフィリン2(PKP2)ハプロ不全が同定された不整脈源性右室心筋症(ARVC)の一例2018
- Author(s)
  中村聡希, 肥後修一朗, 南口仁, 世良英子, 水野裕八國松鈴花, 志波幹夫, 高島成二, 彦惣俊吾, 坂田泰史
- Organizer
  第221回日本内科学会近畿地方会
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Rapid Evaluation of Candidate Causal Gene Mutation using High-content Image Analysis Combined with Targeted Gene Disruption2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Masato Shibamoto, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2018（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19543
[Presentation] Clinical application of genome editing for advanced heart failure2018
- Author(s)
  肥後修一朗、増村雄喜、彦惣俊吾、坂田泰史
- Organizer
  第22回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08069
[Presentation] Therapeutic Genome Editing Targeting an Upstream Genetic Basis of Advanced Heart Failure2018
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo, Shungo Hikoso, Yasushi Sakata
- Organizer
  第82回日本循環器学会学術集会　プレナリーセッション
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 拡張型心筋症遺伝子変異に対する相同組換え修復（HDR）を介したゲノム編集治療の開発2017
- Author(s)
  石津宜丸肥後修一朗　増村雄喜　小濱康明　志波幹夫　肥後友彰　柴本将人　中川彰人　森本幸生　高島成二　彦惣俊吾　坂田泰史
- Organizer
  第2回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 心筋症遺伝子変異に対する相同組換え修復（HDR）を介したゲノム編集治療の開発2017
- Author(s)
  石津宜丸肥後修一朗　志波幹夫　小濱康明　柴本将人　肥後友彰　中川彰人　増村雄喜　森本幸生　彦惣俊吾　坂田泰史
- Organizer
  第3回心筋症研究会 YIA
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Big Data Clinical Research of Osaka CardioVascular Conference (OCVC)-Effort of PURSUIT-HFpEF registry2017
- Author(s)
  1.Hikoso S, Nakatani D, Suna S, Nakagawa A, Yasumura Y, Uematsu M, Yamada T, Dohi T, Kojima T, Matsumura Y, Sakata Y
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢（日本）
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461129
[Presentation] Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes2017
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo,Sachio Morimoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Clarification of the novel mechanism of cardiomyocyte hypertrophy via regulation of RNA metabolism2016
- Author(s)
  増村雄喜, 肥後修一朗, 朝野仁裕, 彦惣俊吾, 坂田泰史, 高島成二
- Organizer
  第33 回ISHR2016
- Place of Presentation
  東京
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] The Role of Cardiomyocyte Apoptosis in the Pathogenesis of Cardiac Remodeling2011
- Author(s)
  彦惣俊吾
- Organizer
  International Academy of Cardiology
- Place of Presentation
  カナダバンクーバー(招待講演)
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-23689042
[Presentation] The in vivo Role of IKKb/NF-kB Signaling Pathway in the Heart2009
- Author(s)
  彦惣俊吾, 他
- Organizer
  第26回国際心臓研究学会日本部会
- Place of Presentation
  札幌
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-21390240
[Presentation] The in Vivo Role of IκB kinase β(IKKβ)/NF-κB Signalling Pathway in the Heart.2009
- Author(s)
  彦惣俊吾
- Organizer
  国際心臓研究学会日本部会総会
- Place of Presentation
  札幌市
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] Constitutive autophagy is required to maintain cardiac structure and function in aged mouse hearts2009
- Author(s)
  種池学、山口修、中井敦子、彦惣俊吾、武田理宏、大宮茂幹、西田和彦、堀正二、水島昇、大津欣也
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] Cardiac-specific Disruption of Calpain4 Revealed Its Cardioprotective Role in Response to Pressure Overload2009
- Author(s)
  溝手勇、山口修、彦惣俊吾、武田理宏、大宮茂幹、松村泰志、西田和彦、堀正二、大津欣也
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] The in vivo Role of IKKb/ NF-kB Signaling Pathway in the Heart2009
- Author(s)
  彦惣俊吾
- Organizer
  第26回国際心臓研究学会日本部会
- Place of Presentation
  札幌
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-21390240
[Presentation] The in vivo Role of IKK /NF- B Signaling Pathway in the Heart2009
- Author(s)
  彦惣俊吾、大津欣也、小室一成、堀正二
- Organizer
  第26回国際心臓研究学会日本部会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] 心筋細胞においてフェリチン重鎖の減少は遊離鉄および酸化ストレスの増加をもたらし細胞死を誘導する2009
- Author(s)
  大宮茂幹、彦惣俊吾、大津欣也
- Organizer
  第19回日本循環薬理学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] The I B kinase (IKK /NF- B signaling pathway protects the heart in response to hemodynamic stress2009
- Author(s)
  彦惣俊吾、大津欣也、堀正二
- Organizer
  第32回心筋代謝研究会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] I B Kinase /NF- B Pathway Protects Hearts from Hemodynamic Stress Mediated through Regulating Manganese Superoxide Dismutase Expression2009
- Author(s)
  S Hikoso, O Yamaguchi, T Takeda, S Omiya, K Suzuki, K Nishida, M Karin, K Otsu
- Organizer
  The 36th Congress of the International Union of Physiological Science
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] The role of IKKβ/NF-κB pathway in the pathogenesis of heart failure2008
- Author(s)
  彦惣俊吾, 他
- Organizer
  第25回国際心臓研究会日本部会
- Place of Presentation
  横浜
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] Cardiac-specific Activation of Apoptosis Signal-regulating Kinase 1 Leads to Cardiac Dysfunction with Pathological Hypertrophy2008
- Author(s)
  武田理宏、大津欣也、山口修、廣谷信一、彦惣俊吾、樋口義治、谷池正行、中井敦子、大宮茂幹、種池学、岡崇史、西田和彦、堀正二
- Organizer
  American Heart Assocoation Scientific Sessions 2008
- Place of Presentation
  アメリカ合衆国、ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] IKKb/NF-kB pathway protects hearts from hemodynamic stress medicated through regulation of MnSOD expression2008
- Author(s)
  Shungo Hikoso
- Organizer
  The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19390214
[Presentation] Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes2008
- Author(s)
  大宮茂幹、彦惣俊吾、大津欣也
- Organizer
  第25回国際心臓研究学会日本部会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] The role of IKK /NF- B pathway in the pathogenesis of heart failure2008
- Author(s)
  彦惣俊吾、山口修、堀正二、大津欣也
- Organizer
  第25回国際心臓研究学会日本部会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] IκB kinase ss (IKKss)/NF-κB signaling pathway protects hearts from hemodynamic stress mediated through regulating MnSOD expression2008
- Author(s)
  彦惣俊吾, 他
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-20790529
[Presentation] IKKb/NF-kB pathway protects hearts from hemodynamic stress medicated through regulation of MnSOD expression2007
- Author(s)
  Shungo Hikoso
- Organizer
  Scientific Sessions, American Heart Association
- Place of Presentation
  Orland, USA
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19390214
[Presentation] I〓B kinase〓 (IKK〓)/NF-B signaling pathway protects hearte from hemodynamic stress mediated through regulating manganese superoxide dismutase expression2007
- Author(s)
  彦惣俊吾
- Organizer
  American Heart Association, Scientific sessions 2007
- Place of Presentation
  Orlando, USA
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-18790498

1. Shuichiro Higo (00604034)

# of Collaborated Projects: 5 results

# of Collaborated Products: 65 results
2. YAMAGUCHI Osamu (90467580)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. OTSU Kinya (20294051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. Sakata Yasushi (00397671)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
5. MURAKAWA Tomokazu

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. NISHIDA Kazuhiko (90362681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. Suna Shinichiro (40573085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 高島成二 (90379272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
9. 中谷大作 (60444535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YASUI Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. UEDA Hiromichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. AKAZAWA Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. TAKEDA Toshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. ASANO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 中山博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡崇史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 柴山浩彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 倉重真沙子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 増村雄喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
23. 奥崎大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 岡本浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 山崎悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 藤尾慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 内藤篤彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 大谷朋仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIKOSO SHUNGO 彦惣 俊吾

HIKOSO Shungo 彦惣 俊吾

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Clarification of molecular pathophysiology and identification of therapeutic target in desmosome-related cardiomyopathyPrincipal Investigator

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Clarification of the role of regulatory mechanism of mitochondria DNA in heart and the application to treatment of heart failurePrincipal Investigator

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Elucidation of mechanism of chronic inflammation originated from mitochondria, and the application for the treatment of heart failurePrincipal Investigator

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The investigation of the role of protein degradation pathway during progression to heart failure, and the application to heart failure treatment.Principal Investigator

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心筋TNF-αの産生制御機構の心不全発症における役割の解明と治療への応用Principal Investigator

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HIKOSO SHUNGO 彦惣俊吾

HIKOSO Shungo 彦惣俊吾