Takashima Seiji 高島成二

… Alternative Names

TAKASHIMA Seiji 高島成二

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Researcher Number	90379272
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院生命機能研究科, 教授 2014 – 2021: 大阪大学, 生命機能研究科, 教授 2014: 大阪大学 2014: 大阪大学, 大学院生命機能研究科, 教授 2013: 大阪大学, 大学院医学系研究科医化学講座, 教授 … More 2012: 大阪大学, 医学系研究科, 准教授 2011: 大阪大学, 大学院・医学系研究科分子心血管医学, 特任准教授 2010: 大阪大学, 医学系研究科, 准教授 2008 – 2010: Osaka University, 医学系研究科, 独立准教授 2008: 大阪大学, 大学院医学系研究科, 准教授 2007: 大阪大学, 保健センター, 助教 2007: 大阪大学, 学内共同利用施設等, 助教 2004 – 2006: 大阪大学, 保健センター, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Cardiovascular medicine / Genome biology / Hygiene
Keywords	Principal Investigator 心不全 / 循環器・高血圧 / ATP合成酵素 / 創薬 / 細胞・組織 / 生体分子 / 分子標的医薬品 / ミオシンATP分解酵素 / エネルギー代謝 / 微小管 … More / 細胞遊走 / 動脈硬化 / 遺伝子治療 / ミトコンドリア病 / アロステリック酵素活性化剤 / 酸化的リン酸化酵素群 / 低酸素 / 心臓拡張機能 / 生活習慣病 / 微小血管障害 / G0s2 / 心臓拡張不全 / ATP / 微小循環障害 / ミトコンドリア / エネルギー需給バランス / 発現制御 / メカニカルストレス / 転写因子 / BNP / シグナル伝達 / エンハンサー / ナトリウム利尿ホルモン / zebrafish / cardiotonic drug / contraction-excitation coupling / drug discovery / Growth Factor / Heart Failure / ゼブラフィッシュ / 強心剤 / 興奮収縮連関 / 増殖因子 / モデル動物 / 利尿ホルモン / エピジェネティクス / ゲノム / 組織・細胞 … More Except Principal Investigator 心不全 / 心筋症 / 遺伝子 / heart failure / ゼブラフィッシュ / ゲノム / 循環器・高血圧 / プロテアソーム / 小胞体ストレス / アデノシン / 病態機序 / リスク因子 / 病原性バリアント / 全ゲノム解析 / ミオシン調節軽鎖キナーゼ / cMLCK / 肥大型心筋症 / HFpEF / 循環器 / 相同組み換え / 心筋細胞 / 拡張型心筋症 / ゲノム編集 / ER stress / apoptosis / proteasome / ubiquitin / アポトーシス / ユビキチン / nitric oxide / adenosine / preconditioning / myocardial infarction / プレコンディショニング / Nitric Oxide / 心筋梗塞 / cardiac-MLCK / 創薬 / ペプチド創薬 / リン酸化酵素 / cardiomyopathy / genetics / イメージング / 神経機能 / 器官形成 / Gal4-UAS / 遺伝子トラップ / トランスポゾン / 発生・分化 / 神経科学 / 遺伝学 / シグナル伝達 / 核酸 / 医歯薬学 / 衛生学 / 社会医学 / 遺伝疫学 / 予防医学 / スプライシング / マイクロアレイ / 冠動脈プラーク破綻 / CHOP / 動脈硬化 / 心筋虚血 / 心不全指標 / 循環器病学 / 臨床試験 / トランスレーショナル研究 / 心不全治療 / 心不全診断 Less

Identification of therapeutic targets for heart failure and development of intervention methods related to the control mechanism of cardiac pump functionPrincipal Investigator
- Principal Investigator
  
  高島成二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
全ゲノム解析基盤による機能・情報統合解析と新規心筋症遺伝子の同定および機序解明
- Principal Investigator
  
  朝野仁裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discoveryPrincipal Investigator
- Principal Investigator
  
  Takashima Seiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
- Principal Investigator
  
  Kitakaze Masafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Therapeutic Application of Genome Editing for Advanced Heart Failure
- Principal Investigator
  
  Shuichiro Higo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug developmentPrincipal Investigator
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
エネルギー代謝と細胞運動の相関解析による新しい循環器病治療薬の開発Principal Investigator
- Principal Investigator
  
  高島成二
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Development of simple and noninvasive method to assess the severity of heart failurePrincipal Investigator
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Cardiac Myosin Light Chain Kinase Mutation as a Cause of Cardiomyopathies
- Principal Investigator
  
  KONNO Tetsuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kanazawa University
Development of novel drugs for heart failure treatment based on modulating kinase activity of cardiac-MLCK
- Principal Investigator
  
  SEGUCHI Osamu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Establishment of a basis to study vertebrate phoneme based on transposon-mediated genetic methods
- Principal Investigator
  
  KAWAKAMI Koichi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Genome biology
- Research Institution
  National Institute of Genetics
The elucidation of mechanisms for myseterin and its susceptibility variant and development of prevention program for moyamoya disease.
- Principal Investigator
  
  KOIZUMI Akio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hygiene
- Research Institution
  Kyoto University
Identification and functional analysis of the factors that interact with cardiac protective factor HB-EGF
- Principal Investigator
  
  YAMAZAKI Satoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Role of splicing variants in heart failure
- Principal Investigator
  
  ASAKURA Masanori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular DiseasePrincipal Investigator
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
新しい概念(エピジェネティクス)を応用した難治性心不全発症分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  高島成二
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Translational research of adenosine aiming for diagnosis and treatment of heart failure
- Principal Investigator
  
  MASAFUMI Kitakaze
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling
- Principal Investigator
  
  MINAMINO Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
New therapeutic approach for heart failure using HB-EGF mediated signal transductionPrincipal Investigator
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The role of ER stress and ubiquitin-proteasome system in the development of heart failrue
- Principal Investigator
  
  MINAMINO Tetsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxide
- Principal Investigator
  
  HORIO Masatsugu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

[Book] 循環器内科2020
- Author(s)
  塚本蔵、斎藤侑希、藤野陽、高島成二、北風政史
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-18H04050
[Journal Article] The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER2023
- Author(s)
  Uegaki Kaiku、Tokunaga Yuji、Inoue Michio、Takashima Seiji、Inaba Kenji、Takeuchi Koh、Ushioda Ryo、Nagata Kazuhiro
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 7 Pages: 112742-112742
- DOI
  10.1016/j.celrep.2023.112742
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18374, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-23K23885, KAKENHI-PLANNED-21H05253, KAKENHI-PLANNED-21H05268, KAKENHI-PUBLICLY-22H05558, KAKENHI-PROJECT-21H04758, KAKENHI-PROJECT-23K27310
[Journal Article] Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier2023
- Author(s)
  Kameda Satoshi、Higo Shuichiro、Shiba Mikio、Kondo Takumi、Li Junjun、Liu Li、Tabata Tomoka、Inoue Hiroyuki、Okuno Shota、Ogawa Shou、Kuramoto Yuki、Yasutake Hideki、Lee Jong-Kook、Takashima Seiji、Ikeda Yoshihiko、Hikoso Shungo、Miyagawa Shigeru、Sakata Yasushi
- Journal Title
  
  JACC: Basic to Translational Science
  
  Volume: - Issue: 6 Pages: 599-613
- DOI
  10.1016/j.jacbts.2022.11.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19526, KAKENHI-PROJECT-21H02915, KAKENHI-PROJECT-22K12801, KAKENHI-PROJECT-21H02914
[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022
- Author(s)
  Oya Ryohei、Tsukamoto Osamu、Hitsumoto Tatsuro、Nakahara Naoya、Okamoto Chisato、Matsuoka Ken、Kato Hisakazu、Inohara Hidenori、Takashima Seiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1747-1747
- DOI
  10.3390/ijms23031747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338
[Journal Article] Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation2022
- Author(s)
  Hakui Hideyuki、Kioka Hidetaka、Miyashita Yohei、Nishimura Shunsuke、Matsuoka Ken、Kato Hisakazu、Tsukamoto Osamu、（3人省略）、Saito Shigeyoshi、Ohta Kunio、Asanuma Hiroshi、Fu Hai Ying、Shinomiya Haruki、Yamada Noriaki、Ohtani Tomohito、Sawa Yoshiki、Kitakaze Masafumi、Takashima Seiji、Sakata Yasushi、Asano Yoshihiro
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 628
- DOI
  10.1126/scitranslmed.abf3274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K08027, KAKENHI-PROJECT-22K08155, KAKENHI-PROJECT-21K15776, KAKENHI-PROJECT-19H03652
[Journal Article] Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes2022
- Author(s)
  Inoue Hiroyuki、Nakamura Satoki、Higo Shuichiro、Shiba Mikio、Kohama Yasuaki、Kondo Takumi、Kameda Satoshi、Tabata Tomoka、Okuno Shota、Ikeda Yoshihiko、Li Junjun、Liu Li、Yamazaki Satoru、Takeda Maki、Ito Emiko、Takashima Seiji、Miyagawa Shigeru、Sawa Yoshiki、Hikoso Shungo、Sakata Yasushi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Issue: 2 Pages: 337-351
- DOI
  10.1016/j.stemcr.2021.12.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08489, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-20K21602, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-21H02915
[Journal Article] Lower B‐type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance2021
- Author(s)
  Okamoto Chisato、Tsukamoto Osamu、Hasegawa Takuya、Hitsumoto Tatsuro、Matsuoka Ken、Takashima Seiji、Amaki Makoto、Kanzaki Hideaki、Izumi Chisato、Ito Shin、Kitakaze Masafumi
- Journal Title
  
  ESC Heart Failure
  
  Volume: 9 Issue: 1 Pages: 636-647
- DOI
  10.1002/ehf2.13700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02914
[Journal Article] ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis2021
- Author(s)
  Min Kyung-Duk、Asakura Masanori、Shirai Manabu、Yamazaki Satoru、Ito Shin、Fu Hai Ying、Asanuma Hiroshi、Asano Yoshihiro、Minamino Tetsuo、Takashima Seiji、Kitakaze Masafumi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 23056-23056
- DOI
  10.1038/s41598-021-02390-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-19H03652
[Journal Article] Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays2020
- Author(s)
  Kamikubo Kenta、Tsukamoto Osamu、Uyama-Saito Yuki、Oya Ryohei、Tsubota Tomoya、Fujino Noboru、Asano Yoshihiro、Kato Hisakazu、Matsuoka Ken、Takashima Seiji
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 160 Issue: 160 Pages: 1-1
- DOI
  10.3791/61168
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-19H03652
[Journal Article] Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy2019
- Author(s)
  Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M
- Journal Title
  
  ESC Heart Fail
  
  Volume: 6 Issue: 2 Pages: 06-415
- DOI
  10.1002/ehf2.12410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04826, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18K15863, KAKENHI-PROJECT-17K09082, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling2018
- Author(s)
  Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 20114-20119
- DOI
  10.1038/s41598-018-20114-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09129, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-17J00085, KAKENHI-PROJECT-17J05937, KAKENHI-PROJECT-15K21388, KAKENHI-PROJECT-17H06566, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-15K09139
[Journal Article] Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats.2017
- Author(s)
  Okuda K, Fu HY, Matsuzaki T, Araki R, Tsuchida S, Thanikachalam PV, Fukuta T, Asai T, Yamato M, Sanada S, Asanuma H, Asano Y, Asakura M, Hanawa H, Hao H, Oku N, Takashima S, Kitakaze M, Sakata Y, Minamino T.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 8 Pages: e0160944-e0160944
- DOI
  10.1371/journal.pone.0160944
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15K12542
[Journal Article] Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor2017
- Author(s)
  Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 44293-44293
- DOI
  10.1038/srep44293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01546, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15K07062
[Journal Article] Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes2017
- Author(s)
  Ishizu T, Higo S, Masumura Y, Kohama Y, Shiba M, Higo T, Shibamoto M, Nakagawa A, Morimoto S, Takashima S, Hikoso S, Sakata Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 9363-9363
- DOI
  10.1038/s41598-017-09716-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-17K16004, KAKENHI-PROJECT-15H04820
[Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.2017
- Author(s)
  Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 7 Pages: 1824-1838
- DOI
  10.1016/j.celrep.2017.10.082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08838, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-15H02511, KAKENHI-PROJECT-15H04685, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-17H04190, KAKENHI-PROJECT-15K08274
[Journal Article] Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts.2017
- Author(s)
  Asanuma H, Sanada S, Yoshitomi T, Sasaki H, Takahama H, Ihara M, Takahama H, Shinozaki Y, Mori H, Asakura M, Nakano A, Sugimachi M, Asano Y, Minamino T, Takashima S, Nagasaki Y, Kitakaze M.
- Journal Title
  
  Cardiovasc Drugs Ther.
  
  Volume: 31 Issue: 5-6 Pages: 501-510
- DOI
  10.1007/s10557-017-6758-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K16398, KAKENHI-PROJECT-25220203, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-16K15628, KAKENHI-PROJECT-15K09139
[Journal Article] Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy.2017
- Author(s)
  Nagata Y, Yamagishi M, Konno T, Nakanishi C, Asano Y, Ito S, Nakajima Y, Seguchi O, Fujino N, Kawashiri MA, Takashima S, Kitakaze M, Hayashi K.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 17417-17417
- DOI
  10.1038/s41598-017-17572-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-17K15995, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15K09134
[Journal Article] Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.2016
- Author(s)
  Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 36946-36946
- DOI
  10.1038/srep36946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy.2016
- Author(s)
  Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 5 Issue: 7
- DOI
  10.1161/jaha.116.003521
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K09111
[Journal Article] A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure.2016
- Author(s)
  Kanzaki M, Asano Y, Ishibashi-Ueda H, Oiki E, Nishida T, Asanuma H, Kato H, Oka T, Ohtani T, Tsukamoto O, Higo S, Kioka H, Matsuoka K, Sawa Y, Komuro I, Kitakaze M, Takashima S, Sakata Y.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 2 Pages: e0148209-e0148209
- DOI
  10.1371/journal.pone.0148209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K09139
[Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.2016
- Author(s)
  Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 28592-28592
- DOI
  10.1038/srep28592
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
[Journal Article] Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213.2015
- Author(s)
  Kotani Y, Morito D, Yamazaki S, Ogino K, Kawakami K, Takashima S, Hirata H, Nagata K.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 16161-16161
- DOI
  10.1038/srep16161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07062, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K14373, KAKENHI-PUBLICLY-15H01546, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-24227009, KAKENHI-PROJECT-25290008, KAKENHI-PROJECT-15H02370
[Journal Article] Beyond Homozygosity Mapping: Family-Control analysis based on Hamming distance for prioritizing variants in exome sequencing.2015
- Author(s)
  Imai A, Nakaya A, Fahiminiya S, Tétreault M, Majewski J, Sakata Y, Takashima S, Lathrop M, Ott J.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 12028-12028
- DOI
  10.1038/srep12028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820
[Journal Article] Higdla is a oositive regulaator of cytochrome c oxidase2015
- Author(s)
  T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
- Journal Title
  
  Proc. Nat. Acad. Sci. U.S.A.
  
  Volume: 112 Issue: 5 Pages: 1553-1558
- DOI
  10.1073/pnas.1419767112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
[Journal Article] Data Mining as a Powerful Tool for Creating Novel Drugs in Cardiovascular Medicine: The Importance of a "Back-and-Forth Loop" Between Clinical Data and Basic Research.2015
- Author(s)
  Kitakaze M, Asakura M, Nakano A, Takashima S, Washio T.
- Journal Title
  
  Cardiovasc Drugs Ther.
  
  Volume: 29 Issue: 3 Pages: 309-15
- DOI
  10.1007/s10557-015-6602-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26540116
[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S..
- Journal Title
  
  Nat Commun.
  
  Volume: 30 Pages: 6137-6150
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670402
[Journal Article] Usefulness and Limitation of Protein Mass Analysis2015
- Author(s)
  Takashima S
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 12 Pages: 2549-2550
- DOI
  10.1253/circj.CJ-15-1101
- NAID
  130005110910
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04820
[Journal Article] Ablation of Rnf213 retards progression of diabetes in the Akita mouse2013
- Author(s)
  Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432 Issue: 3 Pages: 519-525
- DOI
  10.1016/j.bbrc.2013.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00427, KAKENHI-PROJECT-10J05192, KAKENHI-PROJECT-12J05348, KAKENHI-PROJECT-22249020, KAKENHI-PROJECT-22590817, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23590741, KAKENHI-PROJECT-23659329
[Journal Article] Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice.2013
- Author(s)
  Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 304(10) Issue: 10 Pages: H1361-H1369
- DOI
  10.1152/ajpheart.00454.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590817, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591097
[Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs2012
- Author(s)
  Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
- Journal Title
  
  Cardiovasc Drugs Ther.
  
  Volume: 26 Issue: 3 Pages: 217-226
- DOI
  10.1007/s10557-012-6381-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240057, KAKENHI-PROJECT-22590817, KAKENHI-PROJECT-23390305, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-23659388, KAKENHI-PROJECT-24390203
[Journal Article] Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development2011
- Author(s)
  Wanyang Liu, et al
- Journal Title
  
  PLoS ONE
  
  Volume: 6(7) Issue: 7 Pages: e22542-e22542
- DOI
  10.1371/journal.pone.0022542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00427, KAKENHI-PROJECT-10J05192, KAKENHI-PROJECT-19GS0314, KAKENHI-PROJECT-22249020, KAKENHI-PROJECT-22590817, KAKENHI-PROJECT-22710193, KAKENHI-PUBLICLY-23122520, KAKENHI-PROJECT-23590741, KAKENHI-PROJECT-23659329
[Journal Article] Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.2010
- Author(s)
  Hamaoka M, Chinen I, Murata T, Takashima S, Iwamoto R, Mekada E.
- Journal Title
  
  Journal of biochemistry. 148(1)
  
  Pages: 55-69
- NAID
  10027877136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
- Author(s)
  Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S
- Journal Title
  
  Nat Cell Biol.
  
  Volume: 12(6) Issue: 6 Pages: 583-90
- DOI
  10.1038/ncb2060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590817
[Journal Article] Isoform-specific intermolecular disulfide bond formation of hetero chromatin protein 1 (HP1).2010
- Author(s)
  Higo, S.Takashima, S., et al.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285 Pages: 31337-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010
- Author(s)
  Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 48(6) Issue: 6 Pages: 1280-9
- DOI
  10.1016/j.yjmcc.2010.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590817
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration via CLIP-170 phosphorylation.2010
- Author(s)
  Nakano, A., Takashima, S., et al.
- Journal Title
  
  Nat.Cell Biol.
  
  Volume: 12 Pages: 583-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of Genes related to Heart Failure Using Global Gene Expression Profiling of Human Failing Myocardium2010
- Author(s)
  Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamasaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 393(1) Pages: 55-60
- Data Source
  KAKENHI-PROJECT-21590945
[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010
- Author(s)
  Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I.
- Journal Title
  
  Journal of molecular and cellular cardiology. 48(6)
  
  Pages: 1280-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.2010
- Author(s)
  8.Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 393(1) Issue: 1 Pages: 55-60
- DOI
  10.1016/j.bbrc.2010.01.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590817
[Journal Article] X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes.2010
- Author(s)
  Sawada, T., Takashima, S., et al
- Journal Title
  
  J Mol Cell Cardiol.
  
  Volume: 48 Pages: 1280-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010
- Author(s)
  Fu, H.Y., Takashima, S., et al
- Journal Title
  
  Circulation
  
  Volume: 122 Pages: 361-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
- Author(s)
  Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S.
- Journal Title
  
  Nat Cell Biol. 12(6)
  
  Pages: 583-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overload.2010
- Author(s)
  Fu HY, Okada K, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T.
- Journal Title
  
  Circulation. 122(4)
  
  Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Antihypertrophic effects of adiponectin on cardiomyocytes are associated with the inhibition of heparin-binding epidermal growth factor signaling.2010
- Author(s)
  Liao Y, Xuan W, Zhao J, Bin J, Zhao H, Asakura M, Funahashi T, Takashima S, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 393(3)
  
  Pages: 519-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of genes related to heart failure using global gene expression profiling of human failing myocardium.2010
- Author(s)
  Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 393(1)
  
  Pages: 55-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010
- Author(s)
  Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
- Journal Title
  
  The Journal of biological chemistry. 285(41)
  
  Pages: 31337-31347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010
- Author(s)
  5.Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(41) Issue: 41 Pages: 31337-47
- DOI
  10.1074/jbc.m110.155788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590817
[Journal Article] Phosphorylation of myosin regulatory light chain by myosin light chain kinase, and muscle contraction.2009
- Author(s)
  Takashima S.
- Journal Title
  
  Circ J. 73(2)
  
  Pages: 208-213
- NAID
  110007042182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Methamphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca(2+) entry via L-type Ca(2+) channel.2009
- Author(s)
  Sugimoto K, Okamura K, Tanaka H, Takashima S, Ochi H, Yamamoto T, Matoba R.
- Journal Title
  
  Biochem Biophys Res Commun.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling.2009
- Author(s)
  Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
- Journal Title
  
  Biochem Biophys Res Commun. 379(2)
  
  Pages: 374-378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.2009
- Author(s)
  Takahama H, Minamino T, Asanuma H, Fujita M, Asai T, Wakeno M, Sasaki H, Kikuchi H, Hashimoto K, Oku N, Asakura M, Kim J, Takashima S, Komamura K, Sugimachi M, Mochizuki N, Kitakaze M.
- Journal Title
  
  J Am Coll Cardiol. 53(8)
  
  Pages: 709-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts.2009
- Author(s)
  Asai M, Tsukamoto O, Minamino T, Asanuma H, Fujita M, Asano Y, Takahama H, Sasaki H, Higo S, Asakura M, Takashima S, Hori M, Kitakaze M.
- Journal Title
  
  Journal of molecular and cellular cardiology. 46(4)
  
  Pages: 452-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats2009
- Author(s)
  Takahama H, Minamino T, Asanuma H, Fujita M, Asai T, Wakeno M, Sasaki H, Kikuchi H, Hashimoto K, Oku N, Asakura M, Kim J, Takashima S, Komamura K, Sugimachi M, Mochizuki N, Kitakaze M
- Journal Title
  
  Journal of the American College of Cardiology 53(8)
  
  Pages: 709-717
- Data Source
  KAKENHI-PROJECT-19390220
[Journal Article] FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F.2009
- Author(s)
  Yamauchi K, Mizushima S, Tamada A, Yamamoto N, Takashima S, Murakami F.
- Journal Title
  
  J Neurosci. 29(13)
  
  Pages: 4044-4055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Extracellular protein kinase CK2 is a novel associating protein of neuropilin-1.2009
- Author(s)
  Shintani Y, Takashima S, Kato H, Komamura K, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 385(4)
  
  Pages: 618-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.2009
- Author(s)
  Sasaki H, Asanuma H, Fujita M, Takahama H, Wakeno M, Ito S, Ogai A, Asakura M, Kim J, Minamino T, Takashima S, Sanada S, Sugimachi M, Komamura K, Mochizuki N, Kitakaze M.
- Journal Title
  
  Circulation. 119(19)
  
  Pages: 2568-2577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.2009
- Author(s)
  Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K.
- Journal Title
  
  J Exp Med. 206(12)
  
  Pages: 2747-2760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of a novel substrate for TNFalpha-induced kinase NUAK2.2008
- Author(s)
  Yamamoto H, Takashima S, Shintani Y, Yamazaki S, Seguchi O, Nakano A, Higo S, Kato H, Liao Y, Asano Y, Minamino T, Matsumura Y, Takeda H, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 365(3)
  
  Pages: 541-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Higher mortality in heterozygous neuropilin-1 mice after cardiac pressure overload.2008
- Author(s)
  Li F, Zhao H, Liao Y, Takashima S, Asano Y, Shintani Y, Hori M, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 370(2)
  
  Pages: 317-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of p32 as a novel substrate for ATM in heart.2008
- Author(s)
  Kato H, Takashima S, Asano Y, Shintani Y, Yamazaki S, Seguchi O, Yamamoto H, Nakano A, Higo S, Ogai A, Minamino T, Kitakaze M, Hori M.
- Journal Title
  
  Biochem Biophys Res Commun. 366(4)
  
  Pages: 885-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha : DNA microarray analysis.2008
- Author(s)
  Suna S, Sakata Y, Sato H, Mizuno H, Nakatani D, Shimizu M, Usami M, Takashima S, Takeda H, Hori M.
- Journal Title
  
  J Atheroscler Thromb. 15(3)
- NAID
  10022608417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress.2008
- Author(s)
  Zhao H, Liao Y, Minamino T, Asano Y, Asakura M, Kim J, Asanuma H, Takashima S, Hori M, Kitakaze M.
- Journal Title
  
  Hypertens Res. 31(10)
  
  Pages: 1977-1987
- NAID
  10024827861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation.2008
- Author(s)
  Liao Y, Zhao H, Ogai A, Kato H, Asakura M, Kim J, Asanuma H, Minamino T, Takashima S, Kitakaze M.
- Journal Title
  
  Hypertens Res. 31(2)
  
  Pages: 335-344
- NAID
  10024360118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.2007
- Author(s)
  Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M.
- Journal Title
  
  J Mol Cell Cardiol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] A Novel Cardiac Myosin Light Chain Kinase Regulates Sarcomere Assembly in the Vertebrate Heart.2007
- Author(s)
  Osamu Seguchi, Seiji Takashima, Satoru Yamazaki, Masanori Asakura, Yoshihiro Asano, Yasunori Shintani, Masakatsu Wakeno, Tetsuo Minamino, Hiroya Kondo, Hidehiko Furukawa, Kenji Nakamaru, Asuka NaitoTomoko Takahashi, Toshiaki Ohtsuka, Koichi Kawakami, Tadashi Isomura, Soichiro Kitamura, Hitonobu Tomoike, Naoki Mochizuki, Masafumi Kitakaze
- Journal Title
  
  J. of Clin.Invest. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning2007
- Author(s)
  Fujita M, Asanuma H, Hirata A, Wakeno M, Takahama H, Sasaki H, Kim J, Takashima S, Tsukamoto O, Minamino T, Shinozaki Y, Tomoike H, Hori M, Kitakaze M
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology 292(4)
- Data Source
  KAKENHI-PROJECT-19390220
[Journal Article] Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.2007
- Author(s)
  Fujita M, Asanuma H, Hirata A, Wakeno M, Takahama H, Sasaki H, Kim J, Takashima S, Tsukamoto O, Minamino T, Shinozaki Y, Tomoike H, Hori M, Kitakaze M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 292(4)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs.2006
- Author(s)
  Hirata A, Minamino T, Asanuma H, Fujita M, Wakeno M, Myoishi M, Tsukamoto O, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Shiraga M, Kitakaze M, Hori M.
- Journal Title
  
  J Am Coll Cardiol. 48(1)
  
  Pages: 176-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats2006
- Author(s)
  Wakeno M, Minamino T, Seguchi O, Okazaki H, Tsukamoto O, Okada K, Hirata A, Fujita M, Asanuma H, Kim J, Komamura K, Takashima S, Mochizuki N, Kitakaze M
- Journal Title
  
  Circulation 114(18)
  
  Pages: 1923-1932
- Data Source
  KAKENHI-PROJECT-19390220
[Journal Article] The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.2006
- Author(s)
  Tsukamoto, O., Minamino, T., Sanada, S., Okada, K., Hirata, A., Fujita, M., Shintani, Y., Yulin, L., Asano, Y, Takashima, S., Yamasaki, S., Tomoike, H., Hori, M., Kitakaze, M.
- Journal Title
  
  Cardiovasc Drugs Ther 20
  
  Pages: 93-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibition.2006
- Author(s)
  Okazaki H, Minamino T, Tsukamoto O, Kim J, Okada K, Myoishi M, Wakeno M, Takashima S, Mochizuki N, Kitakaze M.
- Journal Title
  
  Hypertens Res. 29(4)
  
  Pages: 277-84
- NAID
  10017985662
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.2006
- Author(s)
  Asanuma H, Minamino T, Ogai A, Kim J, Asakura M, Komamura K, Sanada S, Fujita M, Hirata A, Wakeno M, Tsukamoto O, Shinozaki Y, Myoishi M, Takashima S, Tomoike H, Kitakaze M.
- Journal Title
  
  J Mol Cell Cardiol. 40(5)
  
  Pages: 666-74
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats.2006
- Author(s)
  Wakeno, M., Minamino, T., Seguchi, O., Okazaki, H., Tsukamoto, O., Okada, K., Hirata, A., Fujita, M., Asanuma, H., Kim, J., Komamura, K., Takashima, S., Mochizuki, N., Kitakaze, M.
- Journal Title
  
  Circulation. 114
  
  Pages: 1923-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Long-term stimulation of adenosine Alb receptors begun after myocardial infarction prevents cardiac remodeling in rats.2006
- Author(s)
  Wakeno M, Minamino T, Seguchi O, Okazaki H, Tsukamoto O, Okada K, Hirata A, Fujita M, Asanuma H, Kim J, Komamura K, Takashima S, Mochizuki N, Kitakaze M.
- Journal Title
  
  Circulation. 114(18)
  
  Pages: 1923-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.2006
- Author(s)
  Shintani, Y., Takashima, S., Asano, Y., Kato, H., Liao, Y., Yamazaki, S., Tsukamoto, 0., Seguchi, O., Yamamoto, H., Fukushima, T., Sugahara, K., Kitakaze, M., Hori, M.
- Journal Title
  
  Embo J 25
  
  Pages: 3045-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Patent] モヤモヤ病関連遺伝子及びその利用2010
- Inventor(s)
  小泉昭夫、永田和宏、森戸大介、高島成二、山崎悟、橋本信夫、松浦範夫、人見敏明
- Industrial Property Rights Holder
  京都大学
- Filing Date
  2010-10-22
- Overseas
- Data Source
  KAKENHI-PROJECT-22249020
[Patent] 心臓特異的キナーゼの心不全診断および治療への応用2009
- Inventor(s)
  高島成二, 瀬口理, 朝倉正紀, 北風政史, 大塚敏明, 中丸健治, 合田明日香
- Industrial Property Rights Holder
  国立循環器病センター総長・第一三共株式会社
- Industrial Property Number
  2009-056423
- Filing Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20390225
[Patent] 微小管伸長抑制剤をスクリーニングする方法および微小管伸長抑制剤2009
- Inventor(s)
  北風政史、望月直樹、高島成二、中野敦
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Filing Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-20390225
[Patent] 微小管伸長抑制剤をスクリーニングする方法および微小管伸長抑制剤2009
- Inventor(s)
  北風政史, 望月直樹, 高島成二, 中野敦
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2009-160508
- Filing Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-20390225
[Patent] 心臓特異的キナーゼの心不全診断および治療への応用2009
- Inventor(s)
  高島成二、瀬口理、朝倉正紀, 北風政史、大塚敏明、中丸健治、合田明日香
- Industrial Property Rights Holder
  国立循環器病センター総長・第一三共株式会社
- Filing Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20390225
[Presentation] Rapid Evaluation of Candidate Causal Gene Mutation using High-content Image Analysis Combined with Targeted Gene Disruption2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Masato Shibamoto, Seiji Takashima, Shigeru Miyagawa, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Verification of novel molecular mechanism of cardiac hypertrophy via regulation of mRNA degradation2018
- Author(s)
  Yuki Masumura, Shuichiro Higo, Shungo Hikoso, Seiji Takashima, Yasushi Sakata
- Organizer
  第2回BCVR
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Multiplexed Measurement of Cell-type Specific Calcium Dynamics Using High-content Image Analysis2018
- Author(s)
  Yuki Masumura, Suzuka Kunimatsu, Shuichiro Higo, Takamaru Ishizu, Yasuaki Kohama, Mikio Shiba, Takumi Kondo, Tomoaki Higo, Masato Shibamoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ハイコンテントイメージ解析及びゲノム編集を用いた心筋症遺伝子変異の病原性の迅速な評価系の構築2018
- Author(s)
  増村雄喜、國松鈴花、肥後修一朗、小濱康明、志波幹夫、近藤匠巳、肥後友彰、柴本将人、高島成二、宮川繁、彦惣俊吾、坂田泰史
- Organizer
  第3回心筋症研究会 YIA
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 二度の心停止から蘇生されプラコフィリン2(PKP2)ハプロ不全が同定された不整脈源性右室心筋症(ARVC)の一例2018
- Author(s)
  中村聡希, 肥後修一朗, 南口仁, 世良英子, 水野裕八國松鈴花, 志波幹夫, 高島成二, 彦惣俊吾, 坂田泰史
- Organizer
  第221回日本内科学会近畿地方会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] 拡張型心筋症遺伝子変異に対する相同組換え修復（HDR）を介したゲノム編集治療の開発2017
- Author(s)
  石津宜丸肥後修一朗　増村雄喜　小濱康明　志波幹夫　肥後友彰　柴本将人　中川彰人　森本幸生　高島成二　彦惣俊吾　坂田泰史
- Organizer
  第2回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Development of Homology-directed Repair-mediated Genome Replacement Targeting Pathological Mutation in Cardiomyocytes2017
- Author(s)
  Shuichiro Higo, Takamaru Ishizu, Yuki Masumura, Tomoaki Higo,Sachio Morimoto, Seiji Takashima, Shungo Hikoso, Yasushi Sakata
- Organizer
  AHA scientific sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Single Cell Imaging Analysis Clarifies Quantitative Kinetics of RNA in Cardiomyocytes2016
- Author(s)
  増村雄喜, 肥後修一朗, 朝野仁裕, 北風政史, 坂田泰史, 高島成二
- Organizer
  第89 回日本生化学学会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] Clarification of the novel mechanism of cardiomyocyte hypertrophy via regulation of RNA metabolism2016
- Author(s)
  増村雄喜, 肥後修一朗, 朝野仁裕, 彦惣俊吾, 坂田泰史, 高島成二
- Organizer
  第33 回ISHR2016
- Place of Presentation
  東京
- Year and Date
  2016-12-17
- Data Source
  KAKENHI-PROJECT-16K09500
[Presentation] ゼブラフィッシュモデルによるもやもや病感受性遺伝子mysterinの機能解析2012
- Author(s)
  小林果、山崎悟、高島成二、人見敏明、劉万洋、原田浩二、小泉昭夫
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-22249020
[Presentation] Structure and Function of AAA+/ubiquitin ligase Mysterin/RNF213.2012
- Author(s)
  Daisuke Morito, Yuri Kotani, Kouki Nishikawa, Satoru Yamazaki, Shun-ichiro Iemura, Toru Natsume, Seiji Takashima, Akio Koizumi, Yoshinori Fujimori, Kazuhiro Nagata
- Organizer
  FASEB summer research conferences "Quality Life through Research
- Place of Presentation
  Saxtons River(USA)
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] ゼブラフィッシュモデルによるもやもや病感受性遺伝子mysterinの機能解析2012
- Author(s)
  小林果、山崎悟、高島成二、人見敏明、劉万洋、原田浩二、小泉昭夫
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] Regulation of mysterin, a moyamoya disease-associated protein, by de-ubiquitinating enzyme.2012
- Author(s)
  2.Yuri Kotani, Daisuke Morito, Satoru Yamazaki, Shun-ichiro Iemura, Toru Natsume, Seiji Takashima, Kazuhiro Nagata
- Organizer
  EMBO/EMBL Symposium "Quality Control-From Molecules to Organelles-"
- Place of Presentation
  Heiderberg(Germany)
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] Dipeptidyl-peptidase IV Inhibitor Improved Cardiac Function and Survival in Mice with Pressure Overload Heart Failure.2012
- Author(s)
  Ayako Takahashi, Masanori Asakura, Shin Ito, Min Kyung-Duk, Kazuhiro Shindo , Yin Yan, Yulin Liao, Satoru Yamazaki, Shoji Sanada, Yoshihiro Asano, H atsue Ishibashi-Ueda, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Naoki Mochizuki, Masafumi Kitakaze
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] Structure and function of novel AAA+/Ubiquitin ligase mysterin.2011
- Author(s)
  Daisuke Morito, Kouki Nishikawa, Wangyang Liu, Satoru Yamazaki, Toshiaki Hitomi, Hatasu Kobayashi, Norio Matsuura, Susumu Miyamoto, Seiji Takashima, Nobuo Hashimoto, Yoshinori Fujiyoshi, Akio Koizumi, Kazuhiro Nagata
- Organizer
  Cold Spring Harbor Asia Conference, "Protein Homeostasis in Health & Disease"
- Place of Presentation
  Suzhou (China)
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model.2010
- Author(s)
  Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze
- Organizer
  American Heart Association 83rd Scientific Sessions
- Place of Presentation
  Chicago (USA)
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] 新規巨大ATPアーゼ/ユビキチンリガーゼMysterinは血管新生を制御し、モヤモヤ病(ウイリス動脈輪閉塞症)に関与する2010
- Author(s)
  森戸大介、劉万洋、山崎悟、人見敏明、小林果、松浦範夫、箸方宏州、原田浩二、高島成二、宮本享、橋本信夫、小泉昭夫、永田和宏
- Organizer
  第62回日本細胞生物会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] 新規巨大ATP アーゼ/ ユビキチンリガーゼMysterin は血管新生を制御し,モヤモヤ病(ウイリス動脈輪閉塞症)に関与する2010
- Author(s)
  森戸大介、劉万洋、山崎悟、人見敏明、小林果、松浦範夫、箸方宏州、原田浩二、高島成二、宮本享、橋本信夫、小泉昭夫、永田和宏
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-22249020
[Presentation] Inhalation of Hydrogen Gas Reduced Infarct Size Following Ischemia and Reperfusion via Mitochondrial KATP Channels in Canine Hearts.2010
- Author(s)
  Akemi Yoshida, Hiroshi Asanuma, Hideyuki Sasaki, Shoji Sanada, Satoru Yamazaki, Seiji Takashima, Tetsuo. Minamino, Masanori Asakura, Masafumi Kitakaze
- Organizer
  European Society of Cardiology Congress 2010
- Place of Presentation
  Stockholm (Sweden)
- Data Source
  KAKENHI-PROJECT-22590817
[Presentation] Inhibition of Cardiac Remodeling by Pravastatin is Associated withAmelioration of Endoplasmic Reticulum Stress2008
- Author(s)
  Zhao H, Liao Y, Minamino T, Asano Y, Asakura M, Kim J, Asanuma H, Takashima S, Hori M, Kitakaze M
- Organizer
  米国心臓協会年次学術集会 2008
- Data Source
  KAKENHI-PROJECT-19390220
[Presentation] Paradigm Shift to Epigenetic Memory for the Pathological Understanding of Chronic Heart Failure2008
- Author(s)
  Asano Y, Takashima S, Liao YL, Kitakaze M
- Organizer
  米国心臓協会年次学術集会 2008
- Data Source
  KAKENHI-PROJECT-19390220
[Presentation] Activation of Myocardial AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs; Involvement of eNOS Activation2008
- Author(s)
  Sasaki H, Asanuma H, Fujita M, Takahama H, Asakura M, Kim J, Minamino T, Takashima S, Sanada S, Ito S, Min K, Komamura K, Mochizuki N, Kitakaze M
- Organizer
  米国心臓協会年次学術集会 2008
- Data Source
  KAKENHI-PROJECT-19390220
[Presentation] Management of Hyperphosphatemia Is an Important Novel Therapeutic Target In Chronic Heart Failure2008
- Author(s)
  Asanuma H, Asakura M, Kim J, Takahama H, Sasaki H, Sanada S, Ohara T, Min K, Ito S, Fujita M, Asano Y, Takashima S, Minamino T, Komamura K, Kitakaze M
- Organizer
  米国心臓協会年次学術集会 2008
- Data Source
  KAKENHI-PROJECT-19390220
[Presentation] Polyethylene-glycol coated liposomal adenosine attenuates hypotension and bradycardia and augments cardioprotection against ischemia/repertusion injury in rats - Nano-size drug delivery system targeted to infarcted myocardium2007
- Author(s)
  Takahama H, Minamino T, Asanuma H, Fujita M, Wakeno M, Asakura M, Kim J, Takashima S, Komamura K, Hori M, Mochizuki N, Kitakaze M
- Organizer
  米国心臓協会年次学術集会 2007
- Data Source
  KAKENHI-PROJECT-19390220

1. MASAFUMI Kitakaze (20294069)

# of Collaborated Projects: 10 results

# of Collaborated Products: 30 results
2. MINAMINO Tetsuo (30379234)

# of Collaborated Projects: 9 results

# of Collaborated Products: 29 results
3. YAMAZAKI Satoru (70348796)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
4. ASANO Yoshihiro (60527670)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
5. TSUKAMOTO Osamu (80589151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
6. HORIO Masatsugu (20124779)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. KATO Hisakazu (30589312)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
8. HIGO Shuichiro (00604034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
9. ASAKURA Masanori (80443505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. SEGUCHI Osamu (60570869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KIM Jiyoong (30393226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. OGAI Akiko (90359274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMOIKE Hitonobu (90112333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. NAKATANI Satoshi (80393221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOMAMURA Kazuo (90311448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. ASANUMA Hiroshi (20416217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. KOIZUMI Akio (50124574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. NAGATA Kazuhiro (50127114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. MIYAMOTO Susumu (70239440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. HITOMI Toshiaki (90405275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. HARADA Kouji (80452340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. KAWAKAMI Koichi (70195048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KONNO Tetsuo (50377389)

# of Collaborated Projects: 1 results

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24. TOYOFUKU Toshihiko (60322179)

# of Collaborated Projects: 1 results

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25. TAKEDA Hiroshi (20127252)

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26. 森和俊 (70182194)

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27. 瀬原淳子 (60209038)

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28. 小椋利彦 (60273851)

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29. 日比正彦 (40273627)

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30. 澤本和延 (90282350)

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31. 田村宏治 (70261550)

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32. 石谷太 (40448428)

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33. 吉原良浩 (20220717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 平田普三 (60402450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 和田浩則 (70322708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 政井一郎 (50242087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 伊藤素行 (20377906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 彦惣俊吾 (30423164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
39. 松岡研 (90826190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
40. 木岡秀隆 (70642099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
41. 四宮春輝 (10908213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 藏本勇希 (50843794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 宮下洋平 (60816312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. NAKANO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
45. YAN YI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. MORITO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
47. KOTANI Yuri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. NAKAHARA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. UMEMOTO Eui

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. YOSHITOMI Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. HAGIWARA nobuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. SHIGA tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. LIU Wangyang

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
55. 森本幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 竹内恒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 下内章人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 坂田泰史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 川尻剛照

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 佐藤加代子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 鈴木敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 小倉尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takashima Seiji 高島 成二

TAKASHIMA Seiji 高島 成二

Research Projects

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Identification of therapeutic targets for heart failure and development of intervention methods related to the control mechanism of cardiac pump functionPrincipal Investigator

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Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discoveryPrincipal Investigator

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Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug developmentPrincipal Investigator

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エネルギー代謝と細胞運動の相関解析による新しい循環器病治療薬の開発Principal Investigator

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Development of simple and noninvasive method to assess the severity of heart failurePrincipal Investigator

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Takashima Seiji 高島成二

TAKASHIMA Seiji 高島成二