FUKUDA Hayato 福田隼

Researcher Number	30434450
Other IDs
Affiliation *help	2018 : 長崎大学, 医歯薬学総合研究科（薬学系）, 准教授 2016 – 2017 : 北海道大学, 薬学研究院, 助教 2015 : 北海道大学, 大学院薬学研究院, 助教 2013 – 2015 : 北海道大学, 薬学研究科(研究院), 助教 2012 : 北海道大学, 大学院・薬学研究院, 助教 2009 : 東北大学, 大学院・薬学研究科, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry / Chemical pharmacy
Keywords	Principal Investigator レゾルビン / 不飽和脂肪酸 / シクロプロパン / 安定等価体 / 構造活性相関 / 標的タンパク / 抗炎症活性 / 炎症収束 / 全合成 / エイコサペンタエン酸 … More Except Principal Investigator シクロプロパン / ニトロキシルラジカル / アザアダマンタン / 三次元的多様性 / 不斉酸化 / 配座制御 / 分子設計 / 不斉触媒 / プロテアソーム阻害剤 / 脳保護薬 / オキソアンモニウム塩 / クアトロフェニル / レゾルビン / 有機触媒 / ライブラリー / ラジカル消去 / ペプチドミメティクス / 酸化ストレス / レドックス / アルコール酸化 / アダマンタン / 酸化反応 / ヌクレオシド / ムスカリン受容体 / リン脂質 / ファゴサイトーシス / 三次元多様性 / トルテロジン / 不斉反応 / ペプチドミイメティクス / ニトロキシド / レジデンスタイム / BGT-1 阻害剤 / オキソアンモニウム / 二量等価体 / ホスファチジルセリン / BASE阻害剤 / 分子認識 Less

不飽和脂肪酸の分子構造に基づく炎症収束脂質レゾルビン類の作用機序解析ツールの開発Principal InvestigatorOngoing
- Principal Investigator
  
  福田隼
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
リガンド・リン脂質複合体による超長時間作用型医薬創出法Ongoing
- Principal Investigator
  
  周東智
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Search for target proteins utilizing the stable equivalents of resorvins, pro-resolving lipid mediatorsPrincipal Investigator
- Principal Investigator
  
  FUKUDA Hayato
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
三次元多様性を分子設計上の鍵概念とする論理的創薬方法論の確立Ongoing
- Principal Investigator
  
  周東智
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing property
- Principal Investigator
  
  SHUTO satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Discovery of a stable equivalent of resolvins with potent anti-inflammatory actionPrincipal Investigator
- Principal Investigator
  
  FUKUDA HAYATO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropane
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of oxoammonium-salt-type catalysts for highly enantioselective oxidation of alcohols
- Principal Investigator
  
  IWABUCHI Yoshiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tohoku University
有機ニトロキシルラジカルをモチーフとする酸化ストレス防御活性薬剤の創製
- Principal Investigator
  
  IWABUCHI Yoshiharu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Tohoku University

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation.2017
- Author(s)
  N. Hoshiya, M. Kondo, H. Fukuda, M. Arisawa, J. Uenishi, S. Shuto
- Journal Title
  
  J. Org. Chem.
  
  Volume : 82 Pages : 2535-2544
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction2016
- Author(s)
  Hayato Fukuda, Saki Ito, Kenji Watari, Chihiro Mogi, Mitsuhiro Arisawa, Fumikazu Okajima, Hitoshi Kurose, Satoshi Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume : 7 Pages : 493-497
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-13J03105, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-15H04641, KAKENHI-PROJECT-16K15136
[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016
- Author(s)
  Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
- Journal Title
  
  Org. Lett.
  
  Volume : 18 Pages : 6224-6227
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K12751, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15K18898, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016
- Author(s)
  Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
- Journal Title
  
  J. Med. Chem.
  
  Volume : 59 Pages : 7282-7286
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability2015
- Author(s)
  Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa and Satoshi Shuto
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume : 357 Pages : 1022-1028
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25282240, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-26860003, KAKENHI-PROJECT-15H02495
[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015
- Author(s)
  A. Sasaki, H. Fukuda, N. Shiida, N. Tanaka, A. Furugen, J. Ogura, S. Shuto, N. Mano, H. Yamaguchi
- Journal Title
  
  Anal. Bioanal. Chem
  
  Volume : 407 Pages : 1625-1639
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25460184
[Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst2015
- Author(s)
  Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal.
  
  Volume : 357 Pages : 2119-2124
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Construction of a chiral quaternary carbon center by a radical cyclization/ring-enlargement reaction: synthesis of 4α-azidoethyl carbocyclic ribose, a key unit for the synthesis of cyclic ADP- ribose derivatives of biological importance2015
- Author(s)
  Takatoshi Sato, Takayoshi Tsuzuki, Satoshi Takano, Kohtaro Kato, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  Tetrahedron
  
  Volume : 71 Pages : 5407-5413
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015
- Author(s)
  A. Sasaki, H. Fukuda, N. Shiida, N. Tanaka, A. Furugen, J. Ogura, S. Shuto, N. Mano, H. Yamaguchi
- Journal Title
  
  Anal. Bioanal. Chem
  
  Volume : 407 Pages : 1625-1639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Characterization of imidazopyridine compounds as negative allosteric modulators of proton-sensing GPR4 in extracellular acidification-induced responses.2015
- Author(s)
  A. Tobo, M. Tobo, T. Nakakura, M. Ebara, H. Tomura, C. Mogi, D.-S. Im, N. Murata, A. Kuwabara, S. Ito, H. Fukuda, M. Arisawa, S. Shuto, M. Nakaya, H. Kurose, K. Sato, F. Okajima
- Journal Title
  
  Plos One
  
  Volume : 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Synthesis of 7-Deaza-Cyclic Adenosine-5’-Diphosphate-Carbocyclic-Ribose and its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents.2015
- Author(s)
  S. Takano, T. Tsuzuki, T. Murayama, T. Sakurai, H. Fukuda, M. Arisawa, S. Shuto
- Journal Title
  
  J. Org. Chem
  
  Volume : 80 Pages : 6619-6627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor2014
- Author(s)
  Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume : 5 Pages : 889-893
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051
[Journal Article] Preparation of nonracemic bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling; synthesis of the arylmethyl-cis-cyclopropane structure core.2013
- Author(s)
  Makoto TANABE
- Journal Title
  
  J. Org. Chem.
  
  Volume : 78 Pages : 11714-11720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-24710260, KAKENHI-PUBLICLY-25105702
[Presentation] シクロプロパン構造特性に基づくレゾルビンE2の安定等価体の創製研究2017
- Author(s)
  松原光太郎、池田紘之、石村航平、平島洸基、室本竜太、松田正、福田隼、渡邉瑞貴、周東智
- Organizer
  日本薬学会第137年会
- Place of Presentation
  東北大学川内地区（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18898
[Presentation] 内因性炎症収束脂質レゾルビン類の創薬化学研究2016
- Author(s)
  池田紘之、福田隼、高倉夕季、石村航平、平島洸基、平尾徹、室本竜太、渡邉瑞貴、松田正、周東智
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18898
[Presentation] シクロプロパン構造特性に基づくレゾルビンE2の安定等価体の創製研究2016
- Author(s)
  松原光太郎、池田紘之、石村航平、福田隼、渡邉瑞貴、周東智
- Organizer
  日本薬学会北海道支部第143回例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-15K18898
[Presentation] EFFICIENT SYNTHESIS OF ANTI-INFLAMMATORY LIPID MEDIATOR RESOLVIN E1 AND ITS ANALOGUES2016
- Author(s)
  石村航平、福田隼、渡邉瑞貴、周東智
- Organizer
  The XXIV EFMC International Symposium on Medicinal Chemistry
- Place of Presentation
  マンチェスター（イギリス）
- Year and Date
  2016-08-28
- Data Source
  KAKENHI-PROJECT-15K18898
[Presentation] 内因性炎症収束脂質レゾルビンE2安定等価体の創製2015
- Author(s)
  福田隼，髙倉夕季，石村航平，金田龍太郎，平尾徹，平島洸基，室本竜太，松田正，阿部洋，有澤光弘，周東智
- Organizer
  第４１回反応と合成の進歩シンポジウム
- Place of Presentation
  近畿大学１１月ホール（大阪府東大阪市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K18898
[Presentation] Synthesis and SAR study of resolvin E22014
- Author(s)
  福田　隼
- Organizer
  247th American Chemical Society National Meeting & Exposition
- Place of Presentation
  Dallas Convention Center, Dallas, USA
- Data Source
  KAKENHI-PROJECT-25860087
[Presentation] Synthesis and SAR study of resolvin E2
- Author(s)
  Hayato Fukuda
- Organizer
  DPhG Annual Meeting 2014
- Place of Presentation
  Frankfurt
- Year and Date
  2014-09-24 – 2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-25860087
[Presentation] GABA配座制限に基づく初のGABAトランスポーターBGT-1サブタイプ高選択的阻害剤の創製
- Author(s)
  末政亮大、小林嵩明、井川ありさ、福田隼、阿部洋、井手聡一郎、南雅文、周東智
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ddntification of the first highly selective BGT-I inhibitor based on conformational restriction of GABA.
- Author(s)
  末政亮大、中田和彰、小林嵩明、井川ありさ、福田隼、阿部洋、有澤光弘、井手聡一郎、南雅文、周東智
- Organizer
  The 12th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  札幌
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] PdおよびNi触媒によるシクロプロパン第三級炭素上への芳香環導入反応―効率的化学空間探索型創薬ライブラリーの構築を目指して―
- Author(s)
  星谷尚亨、四辻慶佑、小林嵩明、福田　隼、阿部　洋、有澤光弘、周東　智
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ファゴサイトーシス誘導性ホスファチジルセリン二量体類縁化合物の創製研究
- Author(s)
  佐藤耀、川村周平、平尾徹、室元竜太、福田隼、阿部洋、松田正、周東智
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670048

1. SHUTO Satoshi (70241346)

# of Collaborated Projects : 4results

# of Collaborated Products : 17results
2. IWABUCHI Yoshiharu (20211766)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
3. SHIBUYA Masatoshi (40359534)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. 有澤光弘 (40312962)

# of Collaborated Projects : 2results

# of Collaborated Products : 13results
5. MINAMI Masabumi (20243040)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
6. HIGASHIDA Haruhiro (30093066)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. HIROKAWA Takatugu (20357867)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. ASAI Akira (60381737)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. MATSUDA Tadashi (20212219)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
10. 小松康雄 (30271670)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 山口浩明 (80400373)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
12. 一ノ瀬亘 (00636409)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. ABE HIROSHI

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
14. Hoshiya Naoyuki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. KUROSE HITOSHI

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. WATANABE Mizuki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 岡島史和

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

FUKUDA Hayato 福田 隼

Research Projects

Research Products

Co-Researchers

不飽和脂肪酸の分子構造に基づく炎症収束脂質レゾルビン類の作用機序解析ツールの開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リガンド・リン脂質複合体による超長時間作用型医薬創出法Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for target proteins utilizing the stable equivalents of resorvins, pro-resolving lipid mediatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

三次元多様性を分子設計上の鍵概念とする論理的創薬方法論の確立Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing property

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of a stable equivalent of resolvins with potent anti-inflammatory actionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropane

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of oxoammonium-salt-type catalysts for highly enantioselective oxidation of alcohols

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

有機ニトロキシルラジカルをモチーフとする酸化ストレス防御活性薬剤の創製

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation.2017

Author(s)

Journal Title

Data Source

[Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction2016

Author(s)

Journal Title

Data Source

[Journal Article] Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents2016

Author(s)

Journal Title

Data Source

[Journal Article] Design, Synthesis, and Identification of 4α-azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose a Ca2+-mobilizing Second Messenger2016

Author(s)

Journal Title

Data Source

[Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability2015

Author(s)

Journal Title

Data Source

[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015

Author(s)

FUKUDA Hayato 福田隼