SHUTO Satoshi 周東智

… Alternative Names

Researcher Number	70241346
Other IDs
External Links
Affiliation (Current)	2019: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 北海道大学, 薬学研究院, 教授 2015 – 2016: 北海道大学, 大学院薬学研究院, 教授 2015: 北海道大学, 大学院薬学研究院・創薬有機化学研究室, 教授 2011 – 2015: 北海道大学, 薬学研究科(研究院), 教授 2009 – 2012: Hokkaido University, 大学院・薬学研究院, 教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Science and Engineering / Biological Sciences Except Principal Investigator Biological pharmacy / 医薬分子機能学 / Functional basic dentistry / Ophthalmology / Drug development chemistry / Pharmacology in pharmacy / Physical pharmacy
Keywords	Principal Investigator シクロプロパン / 分子設計 / 配座制御 / cADPR / セカンドメッセンジャー / リン脂質 / カルシウム / ヌクレオシド / ラジカル反応 / 細胞内情報伝達系 … More Except Principal Investigator GDNF / 神経細胞死 / 老化促進モデルマウス / PEPT1 / 生体高分子 / senescence accelerated mouse (SAM) / 脳虚血 / アポトーシス / レチノイド / 代謝拮抗剤 / Caco-2 / ネオカルチノスタチン / 学習記憶障害 / サイクリックADPリボース / NMDAレセプター / 多剤排出輸送体 / 蛍光センサー / ハリコンドリンB / 核酸医薬 / antisense / レニン・アンジオテンシン系 / カルシウム / neuronal cell death / conformational restriction / ペプチドトランスポータ / リン酸ジエステル結合 / イノシトール三リン酸 / アンチセンス / 抗ガン剤 / 神経伝達物質 / （プロ）レニン受容体 / ピレン / リゾリン脂質 / FITC / アポートシス / 腸管吸収 / 受容体結合プロレニン系 / learning deficiency / ザルコシン / シクロプロパン / ミエリン / NMDA receptor / senescence accelerated mouse / トランスポーター / phosphodiester bond / ＧＡＢＡ / 加齢 / endo-nuclease / 配座制御 / Caco2 / Peptide transporter / 立体配座固定 / RNA / アセチルコリン / Phosphatidylinositol 4-kinase / antisense molecule / radical cyclization / 創薬 / マラリア / thermal stability / フローレセッイン / Sw620 / neuronal death / メトキサレート / 連鎖解析 / oligonucleotide / ラジカル反応 / チャネルブロッカー / うつ病 / microRNA / ロ-ダミン123 / miRNA / CREB / 受容体結合プロレニン / senescence accelerated mouse(SAM) / anti-cancer drugs / タキリ-ル / fluorescent substrate / Senescence-accelerated mouse (SAM) / neurotrophic factor / ダイペプチド / クロスリンク / 網脈絡膜疾患 / depressive behavior / multi-efflux transporter / 血管新生 / 受容体 / ヌクレアーゼ抵抗性 / NO / 有機化学 / 神経栄養因子 / methoxylate / ischemia / (プロ)レニン受容体 / brain ischemia / phosphatidylinositol 4-kinase / 分子設計 / グリア細胞株由来 / インターロイキン-1β / ストレス刺激 / quantitative trait Loci analysis (QTL) / アンチセンス核酸 / phosphatididylinositol 4-kinase / 細胞内シグナル / FRET / 脳・神経 / ハマボウフウ / イメージング / exo-nuclease / アンタゴニスト / oligodeoxyribonucleotide / oligonucleotide therapy / 蛍光生輸送基質 / セロトニントランスポーター / channel blocker / サイトカイン / RNaseH / NMDA受容体 / aging / 遅発性神経細胞死 / learning impairments / 虚血モデル / 促進老化マウス / ハリコンンドリンB / 膜輸送 / 蛍光性輸送基質 / 遺伝子 / 核酸 / 4'-branched thymidine / differential display法 / 熱的安定性 / グルタミンシンテターゼ / 薬理学 / 平面脂質二分子膜 / RNase H / タキソ-ル / cyclopropane Less

高分子間相互作用を制御する合成機能分子を論理的・効率的に創出する方法論の確立Principal InvestigatorOngoing
- Principal Investigator
  
  周東智
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Hokkaido University
Development of anti-miRNA oligonucleotides on the basis of structure control.Ongoing
- Principal Investigator
  
  小松康雄
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of new drugs targeting receptor-associated protein system for ocular disordersOngoing
- Principal Investigator
  
  石田晋
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Hokkaido University
A Versatile Strategy for Developing Long-Acting Ligands by Ligand-Phospholipid ConjugationPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
三次元多様性を分子設計上の鍵概念とする論理的創薬方法論の確立Principal InvestigatorOngoing
- Principal Investigator
  
  周東智
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Elucidation of neural GABA transporter function by developing novel subtype-selective inhibitors
- Principal Investigator
  
  MINAMI Masabumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hokkaido University
Development of bioimaging methods for intra- and intercellular messengers
- Principal Investigator
  
  Tanimura Akihiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing propertyPrincipal Investigator
- Principal Investigator
  
  SHUTO satoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropanePrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Investigation of the mechanism of insulin secretion via CaPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Useful β-turn mimetics having three-dimensional diversityPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
発達障害発症機序の解析と治療薬創製研究Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
非イノシトール型イノシトールリン脂質ミミックの創製研究Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of ligands active specifically in intracellular Ca^<2+>-mobilizing second messenger systemPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
配座制御に基づく分子設計:ユビキチン/プロテアソーム系を標的とする制がん剤の創製Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of histamine H_3 receptor selective ligands based on the versatile chiral cyclopropane units.Principal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  HOKKAIDO UNIVERSITY
大環状ピロリン酸構造を持つサイクリックADP-リボース類縁化合物の効率的合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Development of New Silicon Tethers and Their Application to the Synthesis of Anti-HIV NucleosidesPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Preparation of animal model with higher brain dysfunction : studies on evaluation methods of active chemicals
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Design of Nuclease-resistant Antisense Molecules Based on the X-ray Structures of Some Nucleases
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
A Noven Radical Ring-Enlargement Reaction : The Reaction Mechanism and the Medicinal Chemical ApplicationPrincipal Investigator
- Principal Investigator
  
  SHUTO Satoshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hokkaido University
リンパ節転移がんに有効な制がん剤ドラッグデリパリ-システムの開発Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
新規セカンドメッセンジャーCADP−リボースの安定な活性等価体の設計と合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
Development of model animals and cells for neuronal disease
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
生体高分子機能を修飾する抗がん化合物の合成と作用解析
- Principal Investigator
  
  松田彰
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
A study on development of inhibitors for neuronal cell death
- Principal Investigator
  
  MATSUDA Akira
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  HOKKAIDO UNIVERSITY
生体高分子機能を修飾する抗がん化合物の合成と作用解析
- Principal Investigator
  
  MATUDA Akira
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
リンパ節転移がんに対する化学療法剤の開発Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
Drug Delivery System Utilizing Transporters That Recognize Substrates of Relatively Large Molecular Sizes
- Principal Investigator
  
  KAMO Naoki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
シクロプロパン環の立体構造特性に基づく分子設計:NMDA受容体特異的拮抗剤の合成Principal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University
リンパ系への薬物ターゲッティングの合成化学的アプローチPrincipal Investigator
- Principal Investigator
  
  周東智
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hokkaido University

[Book] 有機医薬分子論2011
- Author(s)
  周東智
- Total Pages
  320
- Publisher
  京都廣川書店出版
- Data Source
  KAKENHI-PROJECT-21390028
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-15590096
[Book] オングストロムの分子設計ナノバイオエンジニアリング,化学フロンティア(杉本直己編)2004
- Author(s)
  周東智
- Total Pages
  13
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Ligand-Phospholipid Conjugation: a Versatile Strategy for Developing Long-Acting Ligands that Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand2018
- Author(s)
  S. Kawamura, Y. Ito, T. Hirokawa, E. Hikiyama, S. Yamada, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15136
[Journal Article] Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR232018
- Author(s)
  Deyama, S., Shimoda, K., Suzuki, H., Ishikawa, Y., Ishimura, K., Fukuda, H., Hitora-Imamura, N., Ide, S., Satoh, M., Kaneda, K., Shuto, S., Minami, M.
- Journal Title
  
  Psychopharmacology
  
  Volume: 235 Pages: 329-336
- DOI
  10.1007/s00213-017-4774-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06765, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15K08670
[Journal Article] Highly Conformationally-Restricted Cyclopropane Tethers with three-Dimensional Structural Diversity Drastically Enhance the Cell-Permeability of Cyclic Peptides2017
- Author(s)
  K. Matsui, Y. Kido, R. Watari, Y. Kashima, Y. Yoshida, S. Shuto
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Pages: 1-9
- DOI
  10.1002/chem.201604946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Structure-specific Effects of Lipidated Oxytocin Analogs on Intracellular Calcium Levels, Parental Behavior, Plasma and Cerebrospinal Fluid Oxytocin Concentrations in Mice.2017
- Author(s)
  S. M. Cherepanov, S. Yokoyama, A. Mizuno, W. Ichinose, O. Lopatina, A. A. Shabalova, A. B. Salmina, Y. Yamamoto, H. Okamoto, S. Shuto, H. Higashida
- Journal Title
  
  Pharmacol. Res. Perspect.
  
  Volume: 5 Pages: 1-14
- DOI
  10.1002/prp2.290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Discovery of Novel Indazole Derivatives as Orally Available β3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effect.2017
- Author(s)
  Y. Wada, S. Nakano, A. Morimoto, K. Kasahara, T. Hayash, Y. Takada, H. Suzuki, M. NIwa-Sakai, S. Ohashi, M. Mori, T. Hirokawa, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 60
- DOI
  10.1021/acs.jmedchem.6b01197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] An Entry to Chiral 1,1,2,3-Tetrasubstituted Arylcyclopropanes by Pd(II)-Catalyzed Arylation via Directing Group-Mediated C(sp3)-H Activation2017
- Author(s)
  Hoshiya Naoyuki、Kondo Moemi、Fukuda Hayato、Arisawa Mitsuhiro、Uenishi Jun’ichi、Shuto Satoshi
- Journal Title
  
  J. Org. Chem
  
  Volume: 82 Pages: 2535-2544
- DOI
  10.1021/acs.joc.6b02935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495
[Journal Article] Discovery of Novel Seven-Membered Prostacyclin Analogs as Potent and Selective Prostaglandin FP and EP3 Dual Agonists.2017
- Author(s)
  I. Sugimoto, T. Kambe, T. Okino, T. Obitsu, N. Ohta, T. Nishiyama, A. Kinoshita, T. Fujimoto, H. Egashira, S.Yamane, S. Shuto, K.Tani, T. Maruyama
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 8 Pages: 107-112
- DOI
  10.1021/acsmedchemlett.6b00415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Cyclopropane-based peptidomimetics mimicking wide-ranging secondary structures of peptides: Conformational analysis and their use in rational ligand optimization2017
- Author(s)
  A. Mizuno, T. Kameda, T. Kuwahara, H. Endoh, Y. Ito, S. Yamada, K. Hasegawa, A. Yamano, M. Watanabe, M. Arisawa, S. Shuto
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 23 Pages: 3159-3168
- DOI
  10.1002/chem.201605312
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-17K15476, KAKENHI-PROJECT-16H05106, KAKENHI-PUBLICLY-16H01026
[Journal Article] Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization2017
- Author(s)
  Mizuno Akira、Matsui Kouhei、Shuto Satoshi
- Journal Title
  
  Chem. Eur. J
  
  Volume: 23 Pages: 14394-14409
- DOI
  10.1002/chem.201702119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05106, KAKENHI-PROJECT-15H02495
[Journal Article] Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction.2016
- Author(s)
  Hayato Fukuda, Saki Ito, Kenji Watari, Chihiro Mogi, Mitsuhiro Arisawa, Fumikazu Okajima, Hitoshi Kurose, Satoshi Shuto
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 7 Pages: 493-497
- DOI
  10.1021/acsmedchemlett.6b00014
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-13J03105, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-15H04641, KAKENHI-PROJECT-16K15136
[Journal Article] Development of a Sulfur-Modified Glass-Supported Pd Nanoparticle Catalyst for Suzuki–Miyaura Coupling2016
- Author(s)
  Mincen Xiao, Naoyuki Hoshiya, Katsumasa Fujiki, Tetsuo Honma, Yusuke Tamenori, Satoshi Shuto, Hiromichi Fujioka, Mitsuhiro Arisawa
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 54 Issue: 8 Pages: 1154-1160
- DOI
  10.1248/cpb.c16-00261
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-16K15136
[Journal Article] Design, Synthesis, and Identification of 4”α-Azidoethyl-Cyclic ADP-Carbocyclic-Ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca2+-mobilizing Second Messenger.2016
- Author(s)
  Sato, T.; Watanabe, M.; Tsuzuki, T.; Takano, S.; Murayama, T.; Sakurai, T.; Kameda, T.; Arisawa, M.; Fukuda, H.; Shuto, S.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Pages: 7282-7286
- DOI
  10.1021/acs.jmedchem.6b00437
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] 1, Novel Characteristics of Guanosine 5’-monophosphate 1 Reductase in Pathogenic2 Protozoa Trypanosoma brucei Distinct from Host Animal.2016
- Author(s)
  T. Bessho, T. Okada, C. Kimura, T. Shinohara, A. Tomiyama, A. Imamura, M. Kuwamura, K. Nishimura, K. Fujimori, .S. Shuto, O. Ishibashi, B. K. Kubata, T. Inui
- Journal Title
  
  PLoS Negl. Trop. Dis.
  
  Volume: 10
- DOI
  10.1371/journal.pntd.0004339
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-25242046, KAKENHI-PROJECT-25660231, KAKENHI-PROJECT-16K15136
[Journal Article] Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.2016
- Author(s)
  K. Tatani, M. Hiratochi, N. Kikuchi, Y. Kuramochi, S. Watanabe, Y. Yamauchi, M. Isaji, S, Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Pages: 3719-3731
- DOI
  10.1021/acs.jmedchem.5b01884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-16K15136
[Journal Article] Design and synthesis of cyclopropane congeners of resolvin E2, an endogenous proresolving lipid mediator, as its stable equivalents.2016
- Author(s)
  Fukuda, H; Muromoto, R.; Takakura, Y.; Ishimura, K.; Kanada, R.; Fushihara, D.; Tanabe, M.; Matsubara, K.; Hirao, T.; Hirashima, K.; Abe, Arisawa, M.; Matsuda, T.; Shuto, S.
- Journal Title
  
  Organic Letters
  
  Volume: 18 Pages: 6224-6227
- DOI
  10.1021/acs.orglett.6b02612
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15K12751, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15K18898, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K15136
[Journal Article] Self-Assembled Multilayer-Stabilized Nickel Nanoparticle Catalyst for Ligand-Free Cross-Coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization2016
- Author(s)
  Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal
  
  Volume: 358 Pages: 2449-2459
- DOI
  10.1002/adsc.201600024
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26460002, KAKENHI-PROJECT-15K12184, KAKENHI-PLANNED-25108003, KAKENHI-PROJECT-16H02950
[Journal Article] Pd(II)-Catalyzed Alkylation of Tertiary Carbon via Directing-Group-Mediated C(sp3)-H Activation: Synthesis of Chiral 1,1,2-Trialkyl Substituted Cyclopropanes2016
- Author(s)
  N. Hoshiya, K. Takenaka, S. Shuto, J. Uenishi
- Journal Title
  
  Org. Lett.
  
  Volume: 18 Pages: 48-51
- DOI
  10.1021/acs.orglett.5b03229
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26860003
[Journal Article] A. Tanimura, Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate Using a Novel Fluorescent Ligand and Ligand-Binding Domain Combination.2016
- Author(s)
  Oura, T.; Murata, K.; Morita, T.; Nezu, A.; Arisawa, M.; Shuto, S.; Tanimura, A.
- Journal Title
  
  ChemBioChem.
  
  Volume: 17 Pages: 1509-1512
- DOI
  10.1002/cbic.201600096
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01026, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-26462820, KAKENHI-PROJECT-26462821, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-16K11484, KAKENHI-PROJECT-16K15136
[Journal Article] Non-metathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2+2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes.2016
- Author(s)
  Tomomi Nada, Yusuke Yoneshige, Yasuhiro Ii, Takashi Matsumoto, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  ACS Catl.
  
  Volume: 6 Pages: 3168-3171
- DOI
  10.1021/acscatal.6b00628
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051, KAKENHI-PUBLICLY-16H01026
[Journal Article] Identification of 8-Aminoadenosine Derivatives as a New Class of Human Concentrative Nucleoside Transporter 2 Inhibitors.2015
- Author(s)
  K. Tatani, M. Hiratochi, Y. Nonaka, M. Isaji, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett
  
  Volume: 6 Pages: 244-248
- DOI
  10.1021/ml500343r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-15H02495
[Journal Article] Double carbonylation of aryl iodides with amines under an atmospheric pressure of carbon monoxide using sulfur-modified Au-supported palladium.2015
- Author(s)
  Nozomi Saito Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato
- Journal Title
  
  Green Chem
  
  Volume: 17 Pages: 2358-2361
- DOI
  10.1039/c4gc02469a
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PUBLICLY-25105701, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-26460002, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26293001
[Journal Article] One-pot Olefin Isomerization/ Aliphatic Enamine Ring-closing Metathesis/ Oxidation/ 1,3-Dipolar Cycloaddition for the Synthesis of Isoindolo[1,2-a]isoquinolines.2015
- Author(s)
  Yuki Fujii, Tsunayoshi Takehara, Takeyuki Suzuki, Hiromichi Fujioka, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  Advanced Synthesis & Catalysis
  
  Volume: 357 Pages: 4055-4062
- DOI
  10.1002/adsc.201500680
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-15H04632, KAKENHI-PROJECT-26288051
[Journal Article] Safe Removal of the Allyl Protecting Groups of Allyl Esters using a Recyclable, Low-leaching and Ligand-free Palladium Nanoparticle Catalyst.2015
- Author(s)
  Koji Takagi, Hayato Fukuda, Satoshi Shuto, Akira Otaka, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Catal
  
  Volume: 357 Pages: 2119-2124
- DOI
  10.1002/adsc.201500055
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Synthesis of 7-Deaza-Cyclic Adenosine-5’-Diphosphate-Carbocyclic-Ribose and its 7-Bromo Derivative as Intracellular Ca2+-Mobilizing Agents.2015
- Author(s)
  Satoshi Takano, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  J. Org. Chem
  
  Volume: 80 Pages: 6619-6627
- DOI
  10.1021/acs.joc.5b00723
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Lipo-oxytocin-1, A Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-lasting Effects on Anxiety-related Behavior and Social Avoidance in CD157 Knockout Mice.2015
- Author(s)
  A. Mizuno, S. M. Cherepanov, Y. Kikuchi, A. Fakhrul, S. Akther, K. Deguchi, T. Yoshihara, K. Ishihara, S. Shuto , H. Higashida
- Journal Title
  
  Brain Sci.
  
  Volume: 5 Pages: 3-13
- DOI
  10.3390/brainsci5010003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-26460499, KAKENHI-PROJECT-15H02495
[Journal Article] Construction of a chiral quaternary carbon center by a radical cyclization/ring-enlargement reaction: synthesis of 4α-azidoethyl carbocyclic ribose, a key unit for the synthesis of cyclic ADP-ribose derivatives of biological importance.2015
- Author(s)
  Takatoshi Sato, Takayoshi Tsuzuki, Satoshi Takano, Kohtaro Kato, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Pages: 5403-5413
- DOI
  10.1016/j.tet.2015.05.084
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-26288051
[Journal Article] Rolling Circle Translation of Circular RNA in Living Human Cells2015
- Author(s)
  N. Abe, K. Matsumoto, M. Nishihara, Y. Nakano, A. Shibata, H. Maruyama, S. Shuto, A. Matsuda, M. Yoshida, Y. Ito, H. Abe
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Pages: 16435-16435
- DOI
  10.1038/srep16435
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-25282240
[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses2015
- Author(s)
  Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
- Journal Title
  
  PLoS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0129334
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15KT0063, KAKENHI-PROJECT-15K06767, KAKENHI-PROJECT-15K07772, KAKENHI-PROJECT-15K14976, KAKENHI-PROJECT-15H02495, KAKENHI-PROJECT-25253011, KAKENHI-PROJECT-15H04641, KAKENHI-PROJECT-24500435, KAKENHI-PROJECT-24591349, KAKENHI-PROJECT-26640087, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-25713007
[Journal Article] Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability.2015
- Author(s)
  Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa and Satoshi Shuto
- Journal Title
  
  Advanced Synthesis & Catalysis
  
  Volume: 357 Pages: 1022-1028
- DOI
  10.1002/adsc.201401000
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25282240, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-26860003, KAKENHI-PROJECT-15H02495
[Journal Article] Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS.2015
- Author(s)
  A. Sasaki, H. Fukuda, N. Shiida, N. Tanaka, A. Furugen, J. Ogura, S. Shuto, N. Mano, H. Yamaguchi
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 407 Pages: 1625-1639
- DOI
  10.1007/s00216-014-8412-5
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25460184, KAKENHI-PROJECT-15H02495
[Journal Article] Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists without Cardiovascular Side Effects.2015
- Author(s)
  Y. Wada, H. Shirahashi, T. Iwanami, M. Ogawa, S. Nakano, A. Morimoto, K. Kasahara, E. Tanaka, Y. Takada, S. Ohashi, M. Mori, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 58 Pages: 6048-6057
- DOI
  10.1021/acs.jmedchem.5b00638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02495
[Journal Article] Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A2014
- Author(s)
  S. Kawamura, Y. Unno, T. Hirokawa, A. Asai, M. Arisawa, S. Shuto
- Journal Title
  
  Chemical Communications
  
  Volume: 50 Pages: 2445-2447
- DOI
  10.1039/c3cc48818g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.2014
- Author(s)
  S. Kawamura, Y. Unno, A. Asai, M. Arisawa, S. Shuto
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 57 Pages: 2726-2735
- DOI
  10.1021/jm500045x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.2014
- Author(s)
  Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa, Satoshi Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 22 Pages: 3091-3095
- DOI
  10.1016/j.bmc.2014.04.032
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048, KAKENHI-PROJECT-26288051
[Journal Article] Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor.2014
- Author(s)
  Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto
- Journal Title
  
  ACS Med. Chem. Lett
  
  Volume: 5 Pages: 889-893
- DOI
  10.1021/ml500134k
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051
[Journal Article] Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.2014
- Author(s)
  Shuhei Kawamura, Yuka Unno, Akira Asai, Mitsuhiro Arisawa and Satoshi Shuto
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 57 Pages: 2726-2735
- DOI
  10.1021/jm400542h
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-26288051, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25750048, KAKENHI-PROJECT-25670049
[Journal Article] Ligand-free Suzuki-Miyaura coupling with sulfur-modified gold-supported palladium in the synthesis of a conformationally restricted cyclopropane compound library with three-dimensional diversity.2014
- Author(s)
  Mitsuhiro Arisawa, Takatoshi Sato, Naoyuki Hoshiya, Mohammad Al-Amin, Yuji Kogami and Satoshi Shuto
- Journal Title
  
  ACS Comb. Sci
  
  Volume: 16 Pages: 215-220
- DOI
  10.1021/co4001138
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-26288051
[Journal Article] Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin.2014
- Author(s)
  Shimada H, Haraguchi K, Hotta K, Miyaike T, Kitagawa Y, Tanaka H, Kaneda R, Abe H, Shuto S, Mori K, Ueda Y, Kato N, Snoeck R, Andrei G, Balzarini J.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 22 Pages: 6174-6182
- DOI
  10.1016/j.bmc.2014.08.024
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02962, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-25282240, KAKENHI-PROJECT-25293110
[Journal Article] Three-Dimensional Structural Diversity-Oriented Peptidomimetics Based on the Cyclopropylic Strain.2013
- Author(s)
  Akira Mizuno
- Journal Title
  
  Organic Letters
  
  Volume: 15 Pages: 1686-1689
- DOI
  10.1021/ol400469w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-24710260, KAKENHI-PUBLICLY-25105702, KAKENHI-PUBLICLY-23105502
[Journal Article] Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure.2013
- Author(s)
  Shuhei KAWAMURA
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 11 Pages: 6615-6622
- DOI
  10.1039/c3ob41338a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048
[Journal Article] Conformational Restriction Approach to BACE1 Inhibitors II: SAR Study of the Isocytosine Derivatives Fixed with a cis-Cyclopropane Ring.2013
- Author(s)
  Shuji YONEZAWA
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 23 Pages: 2912-2915
- DOI
  10.1016/j.bmcl.2013.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PUBLICLY-23105502
[Journal Article] Potent Proteasome Inhibitors Derived from the Unnatural Cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action2013
- Author(s)
  Shuhei KAWAMURA
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 56 Pages: 3689-3700
- DOI
  10.1021/jm4002296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-25105702, KAKENHI-PROJECT-25670049, KAKENHI-PROJECT-25750048, KAKENHI-PUBLICLY-23105502
[Journal Article] Cyclopropane-Based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports2013
- Author(s)
  K. Nakada, M. Yoshikawa, S. Ide, A. Suemasa, S. Kawamura, T. Kobayashi, E. Masuda, Y. Ito, W. Hayakawa, T. Katayama, S. Yamada, M. Arisawa, M. Minami, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 21 Pages: 4938-4950
- DOI
  10.1016/j.bmc.2013.06.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Preparation of chiral bromomethylene- cyclopropane and its use in Suzuki–Miyaura coupling : Synthesis of the arylmethyl- (Z)-cyclopropane structure core2013
- Author(s)
  Makoto TANABE
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 78 Pages: 11714-11720
- DOI
  10.1021/jo401675z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-24390023, KAKENHI-PROJECT-24710260, KAKENHI-PUBLICLY-25105702
[Journal Article] Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)-H Bond Activation to Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes2013
- Author(s)
  N. Hoshiya, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Lett
  
  Volume: 15 Pages: 6202-6205
- DOI
  10.1021/ol4030452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03163, KAKENHI-PROJECT-24390023
[Journal Article] Conformational restriction approach to β-secretase (BACE1) inhibitors III: Effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations2013
- Author(s)
  S. Yonezawa, K Fujiwara, T. Yamamoto, K. Hattori, H. Yamakawa, C. Muto, M. Hosono, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 21 Pages: 6506-6522
- DOI
  10.1016/j.bmc.2013.08.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy: Histamine Analogs with the 4-Amino-2,3-methano-1-(1H-imidazol-4-yl)butane Structure as Highly Potent Histamine H3 and/or H4 Receptor Ligands.2012
- Author(s)
  M. Watanabe, T. Kobayashi, T. Hirokawa, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 736-745
- DOI
  10.1039/c1ob06496g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PUBLICLY-23105502
[Journal Article] Synthesis and discovery of N-carbonyl pyrrolidine or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors2012
- Author(s)
  H. Miyakoshi, S. Miyahara, T. Yokogawa, K. T. Chong, J. Taguchi, K. Endoh, W. Yano, T. Wakasa, H. Ueno, Y. Takao, M. Nomura, S. Shuto, H. Nagasawa, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 2960-2969
- DOI
  10.1021/jm201627n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy : Histamine Analogs with the 4-Amino-2,3-methano-1-(1H-imidazol-4-y1) butane Structure as Highly Potent Histamine H3 and/or H4 Receptor Ligands2012
- Author(s)
  M.Watanabe, T.Kobayashi, T.Hirokawa, A.Yoshida, Y.Ito, S.Yamada, N.Orimoto, Y.Yamasaki, M.Arisawa, S.Shuto
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 10 Pages: 736-745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] 1,2,3-Triazole-Containing Uracil Derivatives with Excellent Pharmacokinetics as a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors.2012
- Author(s)
  H. Miyakoshi, S. Miyahara, K. Endoh, J. Taguchi, M. Nomura, Y. Takao, A. Fujioka, A. Hashimoto, K Itou, K. Yamamura, S. Shuto, H. Nagasawa, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 6427-6437
- DOI
  10.1021/jm3004174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Discovery of Highly Potent Human Deoxyuridine Triphosphatase Inhibitors Based on the Conformation Restriction Strategy.2012
- Author(s)
  S. Miyahara, H. Miyakoshi, T. Yokogawa, T. Muto, K. Endoh, W. Yano, T. Wakasa, H. Ueno, K. Itou, M. Nomura, H. Nagasawa, S. Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55, Pages: 5483-5496
- DOI
  10.1021/jm300416h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Cyclopropane-Based Stereochemical Diversity-Oriented Conformational Restriction Strategy : Histamine Analogs with the 4-Amino-2, 3-methano-1-(1H-imidazol-4-yl)butane Structure as Highly Potent Histamine H3 and/or H4 Receptor Ligands.2012
- Author(s)
  M. Watanabe, T. Kobayashi, T. Hirokawa, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Pages: 736-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Conformational Restriction Approach to γ－Secretase (BACE1) Inhibitors: Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode.2012
- Author(s)
  Shuji Yonezawa
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 8838-8858
- DOI
  10.1021/jm3011405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PUBLICLY-23105502
[Journal Article] Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.2012
- Author(s)
  Mitsuhiro Arisawa, Yayoi Kasaya, Tohru Obata, Takuma Sasaki, Tomonori Nakamura, Takuya Araki, Koujirou Yamamoto, Akito Sasaki, Akihito Yamano, Mika Ito, Hiroshi Abe, Yoshihiro Ito, and Satoshi Shuto
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 8152-8163
- DOI
  10.1021/jm301084z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J06507, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors2012
- Author(s)
  S.Miyahara, H.Miyakoshi, T.Yokogawa, K.T.Chong, J.Taguchi, T.Muto, K.Endoh, W.Yano, T.Wakasa, H.Ueno, Y.Takao, A.Fujioka, A.Hashimoto, K.Itou, K.Yamamura, M.Nomura, H.Nagasawa, S.Shuto, M.Fukuoka
- Journal Title
  
  J.Med.Chem.
  
  Volume: 55 Pages: 2970-2980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Ruthenium-Catalyzed Cycloisomerization and Its Application to the Synthesis of (±)-Cinchonaminone.2012
- Author(s)
  Takao Ogawa
- Journal Title
  
  Eur. J. Org. Chem
  
  Volume: - Pages: 3084-3087
- DOI
  10.1002/ejoc.201200260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase Inhibitors.2012
- Author(s)
  S. Miyahara, H. Miyakoshi, T. Yokogawa, K. T. Chong, W. Yano, T. Wakasa, H. Ueno, Y. Takao, A. Fujioka, A. Hashimoto, K. Itou, K. Yamamura, M. Nomura, H. Nagasawa, S. Shuto, M. Fukuoka
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 2970-2980
- DOI
  10.1021/jm201628y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023
[Journal Article] Ligand-Free Buchwald-Hartwig Aromatic Aminations of Aryl Halides Catalyzed by Low-Leaching and Highly Recyclable Sulfur-Modified Gold-Supported Palladium Material.2012
- Author(s)
  Mohammad Al-Amin, Tetsuo Honma, Naoyuki Hoshiya, Takatoshi Sato, Satoshi Shuto, Mitsuhiro Arisawa
- Journal Title
  
  Adv. Synth. Cat.
  
  Volume: 354 Pages: 1061-1068
- DOI
  10.1002/adsc.201100761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03163, KAKENHI-PROJECT-23246013, KAKENHI-PROJECT-23659049, KAKENHI-PROJECT-24390023, KAKENHI-PUBLICLY-23105502
[Journal Article] Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors2012
- Author(s)
  H.Miyakoshi, S.Miyahara, T.Yokogawa, K.T.Chong, J.Taguchi, K.Endoh, W.Yano, T.Wakasa, H.Ueno, Y.Takao, M.Nomura, S.Shuto, H.Nagasawa, M.Fukuoka
- Journal Title
  
  J.Med.Chem.
  
  Volume: 55 Pages: 2960-2969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] One-pot ring-closing metathesis(RCM)/oxidation by an assisted tandem rutheniumcatalysis for the synthesis of 2-quinolones.2012
- Author(s)
  H. Kato, T. Ishigame, N. Oshima, K. Shimawaki, M. Arisawa, S. Shuto
- Journal Title
  
  Adv. Synth. Cat.
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Conformational Restriction Approach to y -Secretase (BACE1)Inhibitors : Effect of a Cyclopropane Ring To Induce an Alternative Binding Mode.2012
- Author(s)
  S. Yonezawa, T. Yamamoto, H. Yamakawa, C. Muto, M. Hosono, K. Hattori, K. Higashino, T. Yutsudo, H. Iwamoto, Y. Kondo, M. Sakagami, H. Togame, Y. Tanaka, T. Nakano, H. Takemoto, M. Arisawa, S. Shuto,
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 8838-8858
- DOI
  10.2174/156802606776743084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390023
[Journal Article] Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance.2011
- Author(s)
  K. Johansson, M. Ito, C. M. S. Schophuizen, S. Mathew, V. Heuser, J. Zhang, M. Shimoji, M. E. Vahter, W. H. Ang, P. J. Dyson, A. Shibata, S. Shuto, Y. Ito, H. Abe, R. Morgenstern
- Journal Title
  
  Mol. Pharmaceut.
  
  Volume: 8 Pages: 1698-1708
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy2011
- Author(s)
  J.Zhang, A.Shibata, M.Ito, S.Shuto, Y.Ito, B.Mannervik, H.Abe. R.Morgenstern
- Journal Title
  
  J.Am.Chem.Soc
  
  Volume: 133 Pages: 14109-14119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.2011
- Author(s)
  J. Zhang, A. Shibata, M. Ito, S. Shuto, Y. Ito, B. Mannervik, H. Abe. R. Morgenstern
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 133 Pages: 14109-14119
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Design and synthesis of conformationally restricted indomethacin analogues that enhance doxorubicin cytotoxicity in multidrug resistant cells without cyclooxygenase inhibitory activity2011
- Author(s)
  M.Arisawa, Y.Kasaya, T.Obata, T.Sasaki, M.Ito, H.Abe, Y.Ito, A.Yamano, S.Shuto
- Journal Title
  
  ACS Med.Chem.Lett
  
  Volume: 2 Pages: 353-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent.2011
- Author(s)
  T. Kobayashi, M. Arisawa, S. Shuto
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 9 Pages: 1219-1224
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.2011
- Author(s)
  M. Watanabe, K. Yamaguchi, W. Tang, K. Yoshida, R. B. Silverman, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 5984-5988
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construction of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent2011
- Author(s)
  T.Kobayashi, M.Arisawa, S.Shuto
- Journal Title
  
  Org.Biomol.Chem
  
  Volume: 9 Pages: 1219-1224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] One-pot ring-closing metathesis(RCM)/oxidation by an assisted tandem rutheniumcatalysis for the synthesis of 2-quinolones2011
- Author(s)
  H.Kato, T.Ishigame, N.Oshima, K.Shimawaki, M.Arisawa, S.Shuto
- Journal Title
  
  Adv.Synth.Cat
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chainconformationally restricted analogues of arginine2011
- Author(s)
  M. Watanabe, K. Yamaguchi, W. Tang, K. Yoshida, R. B. Silverman, M. Arisawa, S. Shuto
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 5984-5988
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21917467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance2011
- Author(s)
  K.Johansson, M.Ito, C.M.S.Schophuizen, S.Mathew, V.Heuser, J.Zhang, M.Shimoji, M.E.Vahter, W.H.Ang, P.J.Dyson, A.Shibate, S.Shuto, Y.Ito, H.Abe, R.Morgenstern
- Journal Title
  
  Mol.Pharmaceut
  
  Volume: 8 Pages: 1698-1708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Alkene isomerization/enamide-ene and diene metathesis for the construetion of indoles, quinolines, benzofurans and chromenes with a chiral cyclopropane substituent2011
- Author(s)
  Kobayashi, T., Arisawa, M., Shuto, S.
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Pages: 1219-1224
- DOI
  10.1039/c0ob00597e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07038, KAKENHI-PROJECT-21390028, KAKENHI-PROJECT-23246013
[Journal Article] Design and synthesis of conformationally restricted indomethacin analogues that enhance doxorubicin cytotoxicity in multidrug resistant cells without cyclooxygenase inhibitory activity.2011
- Author(s)
  M. Arisawa, Y. Kasaya, T. Obata, T. Sasaki, M. Ito, H. Abe, Y. Ito, A. Yamano, S. Shuto
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 2 Pages: 353-357
- Data Source
  KAKENHI-PROJECT-23659049
[Journal Article] Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine2011
- Author(s)
  M.Watanabe, K.Yamaguchi, W.Tang, K.Yoshida, R.B.Silverman, M.Arisawa, S.Shuto
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 19 Pages: 5984-5988
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Synthesis and Structural and Pharmacological Properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H_3/H_4 receptor ligands. Bioorg2010
- Author(s)
  T. Kobayashi, M. Watanabe, A. Yoshida, S. Yamada, M. Ito, H. Abe, Y. Ito, M. Arisawa, S. Shuto
- Journal Title
  
  Med. Chem
  
  Volume: 18 Pages: 1076-1082
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20045649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Investigation of the Bioactive Conformation of Histamine H_3 ReceptorAntagonists by the Cyclopropylic Strain-Based Conformational Restriction Strategy2010
- Author(s)
  M. Watanabe, T. Hirokawa, T. Kobayashi, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto
- Journal Title
  
  J. Med. Chem
  
  Volume: 53 Pages: 3585-3593
- DOI
  10.1021/jm901848b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] Three-dimensional structure-activity relationship study of belactosin A and its stereo and regioisomers : development of potent proteasome inhibitors by the stereochemical diversity-oriented strategy. Org2009
- Author(s)
  K. Yoshida, K. Yamaguchi, A. Mizuno, Y. Unno, A. Asai, T. Sone, H. Yokosawa, A. Matsuda, M. Arisawa, S. Shuto
- Journal Title
  
  Biomol. Chem
  
  Volume: 7 Pages: 1868-1877
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19590782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390028
[Journal Article] ピラノースの配座制御に基づく立体選択的グリコシル化反応2008
- Author(s)
  周東智, 他
- Journal Title
  
  有機合成化学 66
  
  Pages: 50-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] . Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^2+-mobilizing second messenger.2007
- Author(s)
  S. Shuto
- Journal Title
  
  Nucleic Acids Symposium Series 51
  
  Pages: 109-110
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] 創薬化学からミゾリビンを考える:ミゾリビンリン酸はIMPDHの遷移状態模倣型阻害剤である2007
- Author(s)
  周東智
- Journal Title
  
  炎症と免疫 15
  
  Pages: 135-141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390027
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res. Supplement 48
  
  Pages: 67-68
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Chemistry of cyclic ADP-ribose and its analogs.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Curr.Med.Chem. 11
  
  Pages: 827-845
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Chemistry of cyclic ADP-ribose and its analogs.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Curr.Med.Chem. 11
  
  Pages: 827-845
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590096
[Journal Article] Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl) thymidines.2004
- Author(s)
  S.Shuto, et al.
- Journal Title
  
  Nucleic Acids Res.Supplement. 48
  
  Pages: 67-68
- Data Source
  KAKENHI-PROJECT-16023205
[Journal Article] Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Ca-Mobilizing Second Messenger
- Author(s)
  T. Tsuzuki, N. Sakaguchi, T. Kudoh, S. Takano, M. Uehara, T. Murayama, T. Sakurai, M. Hashii, H. Higashida, K. Weber, A. H. Guse, T. Kameda, T. Hirokawa, Y. Kumaki, B. V. L. Potter,H. Fukuda, M. Arisawa, S. Shuto
- Journal Title
  
  Angew.Chem. Int. Ed
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-23659049
[Presentation] trans-1, 2-シクロプロパンジアミンおよびジカルボン酸からなるオリゴアミドの合成研究2018
- Author(s)
  山田圭恭, 一ノ瀬亘, 福田隼, 渡邉瑞貴, 周東智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] シクロプロパンの構造特性に基づく膜透過性環状ペプチドの設計と合成2018
- Author(s)
  植村　真衣, 加藤　七海,松井　耕平, 桑原　智希, 渡邉　瑞貴, 福田　隼, 竹内　恒, 広川　貴次, 武隈　洋, 菅原満, 周東　智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] GABAトランスポーターサブタイプ選択的阻害剤の創出を目的とするGABA配座制限誘導体の設計と合成2018
- Author(s)
  末政亮大、中田和彰、小林嵩明、福田隼、渡邉瑞貴、井手聡一郎、人羅菜津子、南雅文、周東智
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 炎症収束性脂質レゾルビンE1配座制限誘導体の設計と合成2017
- Author(s)
  石村航平，福田隼，渡邉瑞貴，周東智
- Organizer
  第15回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 光学活性1,2,3-三置換シクロプロパンヌクレオシドの合成2017
- Author(s)
  南貴覚、福多洸太朗、星谷尚亨、福田隼、渡邉瑞貴、周東智
- Organizer
  第29回万有札幌シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Spiro-cyclopropane type α-helix/β-strand mimimetics targeting protein-protein interactions2017
- Author(s)
  Tomoki Kuwahara, Akira Mizuno, Hayato Fukuda, Mizuki Watanabe, Satoshi Shuto
- Organizer
  254th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Rational Development of Cyclopropane-Based Target-Selective Compounds such as GABA Transporter Inhibitors2017
- Author(s)
  周東智
- Organizer
  Drug Research Academy
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] シクロプロパンの立体及び立体電子特性に基づくペプチドミメティクス2017
- Author(s)
  桑原智希，植村真衣，水野彰，一ノ瀬亘，松井耕平，福田隼，渡邉瑞貴，周東智
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] 新規GABAトランスポーター阻害薬候補化合物の薬理活性評価2016
- Author(s)
  佐藤孝行、井川ありさ、圓山智嘉史、末政亮大、小林嵩明、有澤光弘、井手聡一郎、周東智、南雅文
- Organizer
  日本薬学会薬理系薬学部会　次世代を担う創薬・医療薬理シンポジウム2016
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-15K14960
[Presentation] GABAトランスポーターサブタイプ特異的な新規阻害薬候補化合物の薬理活性評価2016
- Author(s)
  佐藤孝行、井川ありさ、圓山智嘉史、末政亮大、小林嵩明、有澤光弘、井手聡一郎、周東智、南雅文
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K14960
[Presentation] Design and Synthesis of Biologically Active Compounds Based on the Structural Features of Cyclopropane2016
- Author(s)
  Satoshi Shuto
- Organizer
  The 8th Takeda Science Foundation Symposium on Pharmasciences. Biomolecule-Based Medicinal Science: Featuring Mid-Size Drugs
- Place of Presentation
  武田薬品工業研究所（大阪府吹田市）
- Year and Date
  2016-01-21
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] Medicinal chemical study on cyclic ADP‐ribose for developing the stable and potent agonists and antagonists2015
- Author(s)
  Satoshi Shuto
- Organizer
  FASEB Science Research Conference on NAD Metabolism and Signaling
- Place of Presentation
  Timmendorfer Strand, Germany
- Year and Date
  2015-08-09
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15H02495
[Presentation] A novel method for IP3 measurement with fluorescent adenophostin A derivatives2015
- Author(s)
  Tanimura, Akihiko Akihiro Nezu, Takao Morita, Satoshi Shuto
- Organizer
  Gordon Research Conference, Calcium Signalling
- Place of Presentation
  Sunday River Grand Summit Hotel, ME, USA
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670812
[Presentation] ペプチド性天然物ベラクトシンAをプロトタイプとする高活性非ペプチド性プロテアソーム阻害剤の創製：“Scaffold Hopping”に基づく論理的分子設計と合成2013
- Author(s)
  川村周平（学生最優秀発表賞受賞）、海野雄加、浅井章良、有澤光弘、周東智
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] Ca動員セカンドメッセンジャーの化学 ―細胞内情報伝達系の創薬標的化を目指してー2012
- Author(s)
  周東　智
- Organizer
  産業総合研究所・分子標的創薬セミナー2000.12.6
- Place of Presentation
  産業技術総合研究所生命情報工学研究センター（　東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-23659049
[Presentation] 三次元多様型配座制御法に基づくペプチドミメティックの設計.メラノコルチン受容体リガンドの創製-2011
- Author(s)
  水野彰、三浦志帆、渡辺瑞貴、小田上剛直、小上裕二、有澤光弘、周東智
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島大学(徳島市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Stereochemical Diversity-Oriented Design of Cyclopropane-Based Peptidomimetics : Synthesis of Melanocortin Receptor Ligands2011
- Author(s)
  Mizuno, A.; Miura, S.; Watanabe, M.; Uchida, S.; Yamada, S.; Arisawa, M.; Shuto, S.
- Organizer
  28th Herbert C. Brown Lectures
- Place of Presentation
  Purdue University (USA)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 制がん性プロテアソーム阻害剤ベラクトシンAシス型立体異性体の構造活性相関研究2011
- Author(s)
  川村周平、海野雄加、田中基裕、佐々木磨、浅井章良、有澤光弘、周東智
- Organizer
  第131年会日本薬学会
- Place of Presentation
  グランシップツインメッセ静岡(静岡県)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Design of Stereochemical Diversity-Oriented Cyclopropane-Based Peptidomimetics : Development of Potent Melanocortin Receptor Ligands2011
- Author(s)
  Mizuno, A.; Miura, S.; Watanabe, M.; Uchida, S.; Yamada, S.; Arisawa, M.; Shuto, S.
- Organizer
  Otsu Conference 2011
- Place of Presentation
  大津プリンスホテル(滋賀県)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Structure-Activity Relationship Study of Unnatural cis-Isomer of Belactosin A, a Potent Proteasome Inhibitor2011
- Author(s)
  Shuhei, Kawamura, Yuka, Unno, Motohiro, Tanaka, Takuma, Sasaki, Akira, Asai, Mitsuhiro, Arisawa, and Satoshi, Shuto
- Organizer
  AIMECS 11 8t AFMC International Medicinal Chemistry Symposium Frontier of Medicinal Science
- Place of Presentation
  京王プラザホテル東京(東京都)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Investigation of the bioactive conformation of Histamine H3/H4 receptor antagonists by the conformational restriction strategy2011
- Author(s)
  Kobayashi, T. , Watanabe, M., Hirokawa, T., Yamada, S., Arisawa, M., Shuto, S.
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  京王プラザホテル東京(東京都)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 光学活性シクロプロパンを有する複素環化合物合成法の開発2010
- Author(s)
  小林嵩明、有澤光弘、周東智
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山県)、岡山大学(岡山市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Enamide-ene methasesis for constructing chiral 2-cyclopropylheterocycles : Indole, quinoline, benzofuran and chromene2010
- Author(s)
  Kobayashi, T., Arisawa, M., Shuto, S.
- Organizer
  240th American Chemical Society National Meeting
- Place of Presentation
  Boston Convention & Exposition Center (USA)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] 立体多様性を鍵とするシクロプロパン型ペプチドミメティック-メラノコルチン受容体リガンドの創製研究-2009
- Author(s)
  水野彰、梶原浩気、三浦志帆、渡辺瑞貴、吉田徳、内田信也、山田静雄、小田上剛直、小上裕二、有澤光弘、周東智
- Organizer
  第7回次世代を担う有機化学シンポジウム
- Place of Presentation
  大阪大学(吹田市)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] シクロプロパン歪みに基づくヒスタミンH3受容体リガンドの設計と活性配座解析2009
- Author(s)
  小林嵩明、渡辺瑞貴、広川貴次、吉田徳、伊東由彦、山田静雄、有澤光弘、周東智
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学(文京区)
- Data Source
  KAKENHI-PROJECT-21390028
[Presentation] Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^<2+>-mobilizing second messenger2007
- Author(s)
  周東智
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京(東京大学安田講堂)
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] "Design, synthesis, and biological activity of carbocyclic analogues of cyclic ADP-ribose, a Ca^<2+>-mobilizing second messenger"2007
- Author(s)
  Satoshi Shuto
- Organizer
  5^<th> Internarnational Symposimon Nucleic Acid Chemistry (Tokyo)
- Place of Presentation
  Tokyo University
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Synthesis of 5"-substituted cyclic ADP-carbocyclic ribose as hiologicaltools"2006
- Author(s)
  Natsum Sakaguchi, Takashi Kudoh, Takashi Murayama, Mitsuhiro Arisawa, Satoshi Shuto
- Organizer
  33th Nucleic Acd Symposium (Osaka)
- Place of Presentation
  Osaka University
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Synthesis and biological activity of 4", 6"-unsaturatred cyclic ADP-carbocyclic-ribose2005
- Author(s)
  Takashi Kudoh, Takashi Murayama, Akira Matsuda, Satoshi Shuto
- Organizer
  4^<th> Internarnational Symposium on Nucleic Acid Chemistry (Fuuoka) 2005
- Place of Presentation
  Kyushu University Faculty of Medicine
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390027
[Presentation] Ca動員セカンドメッセンジャーの化学-細胞内情報伝達系の創薬標的化を目指して2000
- Author(s)
  周東智
- Organizer
  産業総合研究所・分子標的創薬セミナー
- Place of Presentation
  産業技術総合研究所生命情報工学研究センター(東京都江東区)
- Year and Date
  2000-12-06
- Data Source
  KAKENHI-PROJECT-23659049
[Presentation] Development of Potent Ligands by the Three-Dimensional Diversity-Oriented Strategy Based on the Characteristic Stereo-and Stereoelectronic Feature of Cyclopopane.
- Author(s)
  Satoshi Shuto
- Organizer
  Frontier in Medicinal Chemistry
- Place of Presentation
  Marburg (Germany)
- Year and Date
  2015-03-15 – 2015-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ddntification of the first highly selective BGT-I inhibitor based on conformational restriction of GABA.
- Author(s)
  末政亮大、中田和彰、小林嵩明、井川ありさ、福田隼、阿部洋、有澤光弘、井手聡一郎、南雅文、周東智
- Organizer
  The 12th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  札幌
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] ファゴサイトーシス誘導性ホスファチジルセリン二量体類縁化合物の創製研究
- Author(s)
  佐藤耀、川村周平、平尾徹、室元竜太、福田隼、阿部洋、松田正、周東智
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25670048
[Presentation] PdおよびNi触媒によるシクロプロパン第三級炭素上への芳香環導入反応―効率的化学空間探索型創薬ライブラリーの構築を目指して―
- Author(s)
  星谷尚亨、四辻慶佑、小林嵩明、福田　隼、阿部　洋、有澤光弘、周東　智
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24390023
[Presentation] GABA配座制限に基づく初のGABAトランスポーターBGT-1サブタイプ高選択的阻害剤の創製
- Author(s)
  末政亮大、小林嵩明、井川ありさ、福田隼、阿部洋、井手聡一郎、南雅文、周東智
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24390023

1. MATUDA Akira (90157313)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. FUKUDA Hayato (30434450)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
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# of Collaborated Projects: 3 results

# of Collaborated Products: 60 results
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# of Collaborated Projects: 3 results

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# of Collaborated Products: 6 results
7. NOMURA Yasuyuki (00034041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MURAYAMA Toshihiko (90174317)

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# of Collaborated Products: 0 results
9. OKUMA Yasunobu (20127939)

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# of Collaborated Products: 0 results
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11. 堀田清 (50181540)

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12. 影近弘之 (20177348)

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13. 佐々木琢磨 (90109976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. SHIMAWAKI Ken (60451407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. HIGASHIDA Haruhiro (30093066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. HIROKAWA Takatugu (20357867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. ASAI Akira (60381737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MATSUDA Tadashi (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. KAMO Naoki (10001976)

# of Collaborated Projects: 1 results

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20. NARA Toshifumi (30241350)

# of Collaborated Projects: 1 results

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21. MIYAUCHI Seiji (30202352)

# of Collaborated Projects: 1 results

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22. YOSHII Kiyonori (30125364)

# of Collaborated Projects: 1 results

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23. HATTORI Masao (40126545)

# of Collaborated Projects: 1 results

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24. SAITO Hiroshi (00012625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Tanimura Akihiko (70217149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. Morita Takao (20326549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. Nezu Akihiro (00305913)

# of Collaborated Projects: 1 results

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28. 南川典昭 (40209820)

# of Collaborated Projects: 1 results

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29. 上野義仁 (20250467)

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30. 山口浩明 (80400373)

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31. 一ノ瀬亘 (00636409)

# of Collaborated Projects: 1 results

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32. 平野悠 (70415735)

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33. 石田晋 (10245558)

# of Collaborated Projects: 1 results

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34. 神田敦宏 (80342707)

# of Collaborated Projects: 1 results

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35. 渡邉瑞貴 (20507173)

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36. 藤原広一 (40837853)

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37. 後藤佑樹 (70570604)

# of Collaborated Projects: 1 results

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38. WATANABE Tohru

# of Collaborated Projects: 1 results

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39. MOGI Chihiro

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# of Collaborated Products: 3 results
40. SAITO Nozomi

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41. OKAJIMA Fumikazu

# of Collaborated Projects: 0 results

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42. MURATA Kaori

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43. 海野雄加

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44. 黒瀬等

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45. 佐藤美洋

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46. 藤岡弘道

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47. 乾隆

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48. 石橋宰

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49. 西村重徳

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50. 石原克彦

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51. 阿部洋

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52. 為則雄祐

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53. 佐藤幸市

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54. 戸村秀明

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55. 仲矢道雄

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56. 村田直哉

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58. 金田勝幸

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60. 井手聡一郎

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61. 人羅菜津子

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62. 根津顕弘

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63. 加藤宣之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHUTO Satoshi 周東 智

SHUTOH Satoru 周東 智

Research Projects

Research Products

Co-Researchers

高分子間相互作用を制御する合成機能分子を論理的・効率的に創出する方法論の確立Principal InvestigatorOngoing

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Review Section

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Development of anti-miRNA oligonucleotides on the basis of structure control.Ongoing

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Development of new drugs targeting receptor-associated protein system for ocular disordersOngoing

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A Versatile Strategy for Developing Long-Acting Ligands by Ligand-Phospholipid ConjugationPrincipal Investigator

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三次元多様性を分子設計上の鍵概念とする論理的創薬方法論の確立Principal InvestigatorOngoing

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Elucidation of neural GABA transporter function by developing novel subtype-selective inhibitors

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Development of bioimaging methods for intra- and intercellular messengers

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Design and synthesis of phosphatidylserine dimers with antitumor effect via the phagocytosis-inducing propertyPrincipal Investigator

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Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropanePrincipal Investigator

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Investigation of the mechanism of insulin secretion via CaPrincipal Investigator

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Useful β-turn mimetics having three-dimensional diversityPrincipal Investigator

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発達障害発症機序の解析と治療薬創製研究Principal Investigator

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非イノシトール型イノシトールリン脂質ミミックの創製研究Principal Investigator

Principal Investigator

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SHUTO Satoshi 周東智

SHUTOH Satoru 周東智