IBUSUKI Mutsuko 指宿睦子

Researcher Number	30448526
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2016: 熊本大学, 医学部附属病院, 寄附講座教員 2014: 熊本大学, 大学院生命科学研究部, 助教 2012 – 2014: 熊本大学, その他の研究科, 助教 2012 – 2014: 熊本大学, 生命科学研究部, 助教 2011: 熊本大学, 大学院・生命科学研究部, 助教
Review Section/Research Field	Principal Investigator Tumor diagnostics / General surgery Except Principal Investigator General surgery
Keywords	Principal Investigator 治療効果予測因子 / 術前ホルモン療法 / 内分泌療法感受性 / 乳癌 / ホルモン療法 / 効果予測 / 乳がん / 効果予測因子 Except Principal Investigator 乳癌 / 予後因子 … More / 乳腺外科学 / ユビキチンリガーゼ / Fbw7 / skp2 / トリプルネガティブ乳癌 / Skp2 / 細胞周期 / MACC1 / ｃMet / 転写因子 / Breast cancer / c－Met / c-Met / 予後予測因子 / 効果予測因子 / 予後予測ツール / 多遺伝子発現 / 予後予測 / 効果予測 / 乳がん Less

Predictive tool for endocrine response of breast cancerPrincipal Investigator
- Principal Investigator
  
  Yamamoto-Ibusuki Mutsuko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
  General surgery
- Research Institution
  Kumamoto University
Generation of a complihensive predictor for neoadjuvant endocrine therapy responsiveness in breast cancerPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO-IBUSUKI Mutsuko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
  General surgery
- Research Institution
  Kumamoto University
The role of MACC1 in breast cancer
- Principal Investigator
  
  YAMAMOTO YUTAKA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
Development of quantitative evaluation tool using multigene expression to predict efficacy of endocrine therapy for breast cancer
- Principal Investigator
  
  IWASE Hirotaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University
Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancer
- Principal Investigator
  
  YAMAMOTO Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kumamoto University

All 2017 2016 2015 2014 2013 2012 2011 2009 Other

All Journal Article Presentation

[Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016
- Author(s)
  Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
- Journal Title
  
  Cancer Science
  
  Volume: in press Pages: 469-477
- DOI
  10.1111/cas.12883
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-25290062, KAKENHI-PROJECT-15K21237, KAKENHI-PROJECT-15K10083
[Journal Article] Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.2016
- Author(s)
  2.Tomiguchi M, Yamamoto Y, Yamamoto-Ibusuki M, Goto-Yamaguchi L, Fujiki Y, Fujiwara S, Sueta A, Hayashi M, Takeshita T, Inao T, Iwase H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107(4) Pages: 491-491
- DOI
  10.1111/cas.12897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21237, KAKENHI-PROJECT-15K21239
[Journal Article] Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients2016
- Author(s)
  63.Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Omoto Y, Iwase H.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Pages: 32504-18
- DOI
  10.18632/oncotarget.8839
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461952, KAKENHI-PROJECT-15K21237, KAKENHI-PROJECT-15K10057
[Journal Article] Targeted therapies for ER+/HER2- metastatic breast cancer.2015
- Author(s)
  Yamamoto-Ibusuki M, Arnedos M, Andre F.
- Journal Title
  
  BMC Med
  
  Volume: 9 Pages: 137-137
- DOI
  10.1186/s12916-015-0369-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K21237
[Journal Article] Differential role of MACC1 expression and its regulation of the　HGF/c‑Met pathway between breast and colorectal cancer2015
- Author(s)
  Sueta A, Yamamoto Y, Yamamoto-Ibusuki M, Hayashi M, Takeshita T, Yamamoto S, Omoto Y, Iwase A
- Journal Title
  
  International Journal of Oncology
  
  Volume: 46 Pages: 2143-2153
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591909
[Journal Article] C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.2015
- Author(s)
  Yamamoto-Ibusuki M, Yamamoto Y, Fujiwara S, Sueta A, Yamamoto S, Hayashi M, Tomiguchi M, Takeshita T, Iwase H
- Journal Title
  
  Eur J Hum Genet
  
  Volume: Epub Pages: 2143-53
- DOI
  10.1038/ejhg.2014.219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591910, KAKENHI-PROJECT-15K21237
[Journal Article] Clinical Significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtype2014
- Author(s)
  Sueta A, Yamamoto Y, Hayashi M, Yamamoto S, Inao T, Ibusuki M, MUrakami M, Iwase H
- Journal Title
  
  Surgery
  
  Volume: Epub
- DOI
  10.1016/j.surg.2014.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] A complehensove analysis of Aurora A; transcript levels are most reliable in association with proliferation and prognosis in breast cancer2013
- Author(s)
  Yamamoto S, Yamamoto-Ibusuki M, yamamoto Y, Fujiwara S, Iwase H
- Journal Title
  
  BMC cancer
  
  Volume: 13 Pages: 217-217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer.2012
- Author(s)
  Yamamoto-Ibusuki M, Yamamoto Y, Yamamoto S, Fujiwara S, Fu P, Honda Y, Iyama K, Iwase H.
- Journal Title
  
  Mod Pathol
  
  Volume: 26 Pages: 79-86
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] High survivin mRNA expression is a predictor of poor prognosis in breast cancer: a comparative study at the mRNA and protein level.2012
- Author(s)
  Xu C, Yamamoto-Ibusuki M, Yamamoto Y, Yamamoto S, Fujiwara S, Murakami K, Okumura Y, Yamaguchi L, Fujiki Y, Iwase H.
- Journal Title
  
  Breast Cancer
  
  Volume: Epub ahead of prinｔ Pages: 20-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.2012
- Author(s)
  Fujiwara S, Ibusuki M, Yamamoto S, Yamamoto Y, Iwase H.
- Journal Title
  
  Breast Cancer.
  
  Volume: Epub ahead of prinｔ Pages: 20-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591910
[Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients2011
- Author(s)
  Ibusuki M, Yamamoto Y, Shinriki S, Ando Y, Iwase H
- Journal Title
  
  Cancer Sci
  
  Volume: 102(2) Pages: 439-45
- NAID
  10029290404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients.2011
- Author(s)
  Ibusuki M, Yamamoto Y, Shinriki S, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 439-445
- NAID
  10029290404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Journal Article] Clinical significance of basal-like subtype in triple-negative breast cancer2009
- Author(s)
  Yamamoto Y, Ibusuki M, Iwase H, et al
- Journal Title
  
  Breast Cancer VOL.16
  
  Pages: 260-270
- NAID
  10027254696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591671
[Presentation] “BRCAness”; a potential predictor needing the additional therapeutics.2017
- Author(s)
  Mutsuko Yamamoto‐Ibusuki.
- Organizer
  15th St. Gallen International Breast Cancer Conference.
- Place of Presentation
  Vienna
- Year and Date
  2017-03-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21237
[Presentation] Luminal型乳癌における包括的予後スコア創出の試みとその有用性2012
- Author(s)
  指宿睦子、山本　豊、山本聡子、藤原沙織、村上敬一、岩瀬弘敬
- Organizer
  第20回日本乳癌学会学術総会
- Place of Presentation
  熊本　ホテル日航熊本
- Invited
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Tha advantage of copy number variation assay of ERBB2 using FFPE specimens: a comprehensive study2012
- Author(s)
  Ibusuki M,Yamamoto Y, Yamamoto S, Fujiwara S, Iwase H
- Organizer
  The 20th Annual Meeting of The Japanese Breast Cancer Society
- Place of Presentation
  Kumamoto,Japan,Hotel Nikko Kumaoto
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] Redu ced expression of ubiquitin ligase FB XW7 mRNA is associated with poor prog nosis in breast cancer patients2011
- Author(s)
  Ibusuki M, Yamamoto Y, Iwase H
- Organizer
  Adva nces in Breast Cancer Research
- Place of Presentation
  サンフランシスコ、米国
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21591671
[Presentation] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients2011
- Author(s)
  指宿睦子、山本豊、岩瀬弘敬
- Organizer
  Advances in Breast Cancer Research
- Place of Presentation
  米国サンフランシスコ
- Data Source
  KAKENHI-PROJECT-21591671
[Presentation] Ethinylestradiol treatment downregulates ER and upregulates PgR; Immunohistochemical analysis in postmenopausal breast cancer tissues after prior long-term estrogen-deprivation therapy
- Author(s)
  Hirotaka Iwase, Yoko Omoto, Takeshi Takeshita, Mutsuko Yamamoto-Ibusuki, Mitsuhiro Hayashi, Aiko Sueta, Saori Fujiwara, Yutaka Yamamoto
- Organizer
  23rd San Antonio Breast Cancer Syposium
- Place of Presentation
  San Antonio
- Year and Date
  2014-12-10 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24591910
[Presentation] A role of MACC1 expression and its regulation of the HGF/c-Met pathway in breast cancer
- Author(s)
  Aiko S, Yamamoto Y, Hayashi M, Takeshita T, Yamamoto-Ibusuki M, Iwase H
- Organizer
  37th　San Antonio Breast Cancer symposium
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2014-12-06 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24591909

1. YAMAMOTO Yutaka (20398217)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. IWASE Hirotaka (40211065)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. KONDO Eisaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中潟直己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 岩田孝吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 桑原一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 林光博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大本陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IBUSUKI Mutsuko 指宿 睦子

Research Projects

Research Products

Co-Researchers

Predictive tool for endocrine response of breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of a complihensive predictor for neoadjuvant endocrine therapy responsiveness in breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of MACC1 in breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of quantitative evaluation tool using multigene expression to predict efficacy of endocrine therapy for breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibroblast growth factor receptor-1 protein expression is associated with prognosis in estrogen receptor-positive/human epidermal growth factor receptor-2-negative primary breast cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeted therapies for ER+/HER2- metastatic breast cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential role of MACC1 expression and its regulation of the HGF/c‑Met pathway between breast and colorectal cancer2015

Author(s)

Journal Title

Data Source

[Journal Article] C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Significance of pretherapeutic Ki67 as a predictive parameter for response to neoadjuvant chemotherapy in breast cancer; is it equally useful across tumor subtype2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A complehensove analysis of Aurora A; transcript levels are most reliable in association with proliferation and prognosis in breast cancer2013

Author(s)

Journal Title

Data Source

[Journal Article] Comparison of prognostic values between combined immunohistochemical score of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67 and the corresponding gene expression score in breast cancer.2012

Author(s)

Journal Title

Data Source

[Journal Article] High survivin mRNA expression is a predictor of poor prognosis in breast cancer: a comparative study at the mRNA and protein level.2012

Author(s)

Journal Title

Data Source

IBUSUKI Mutsuko 指宿睦子

[Journal Article] Differential role of MACC1 expression and its regulation of the　HGF/c‑Met pathway between breast and colorectal cancer2015