MAKINO Shigeru 牧野茂

… Alternative Names

牧野茂マキノシゲル

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Researcher Number	30462732
Affiliation (based on the past Project Information) *help	2021: 国立研究開発法人理化学研究所, バイオリソースセンター, 開発研究員 2018 – 2019: 公益財団法人がん研究会, がん研究所がんゲノム研究部, 研究員 2017: 国立研究開発法人理化学研究所, バイオリソースセンター, 開発研究員 2015: 国立研究開発法人理化学研究所, バイオリソースセンター, 開発研究員 2013 – 2014: 独立行政法人理化学研究所, バイオリソースセンター, 開発研究員 2009 – 2012: The Institute of Physical and Chemical Research, 新規変異マウス研究開発チーム, 開発研究員
Review Section/Research Field	Principal Investigator Basic Section 45010:Genetics-related / Cell biology / Laboratory animal science Except Principal Investigator Environmental impact assessment / Laboratory animal science
Keywords	Principal Investigator ゲノム編集 / 突然変異マウス / 神経管形成 / 形態形成 / Sufu / ヘッジホグシグナル伝達 / 翻訳開始コドン / mRNAの翻訳 / ヘッジホグシグナル / 疾患モデル … More / マウス遺伝学 / フレームシフト変異 / 開始コドン / 定型外翻訳 / イメージング / 四肢形態形成 / ENU突然変異 / マウス / Gli転写因子 / GLI3転写因子 / 翻訳再開 / CRISPR-Cas9 / タンパク質の可視化 / SUFU / GLI転写因子 / 発生 / 点突然変異 / gene-driven mutagenesis / ENU / タンパク質の安定性 / Gli / Gene-driven mutagenesis / Gli3 / 発がん / ENUミュータジェネシス / 点突然変異マウス … More Except Principal Investigator バイオインフォーマティクス / ゲノム解析 / 遺伝学 / マウス / 次世代シーケンシング / 突然変異 / ミュータジェネシス / オミクス解析 / モデルマウス / 進化 / トランスクリプトーム解析 / バイオインフォマティクス / 進化学 / 自然発生突然変異 / 動物モデル / SDG / 次世代影響評価 / ゲノム学 / 量的遺伝学 / 集団遺伝学 / 次世代リスク評価 / 変異率 / 自然変異 / 生物多様性 / 全ゲノム解読 / 実験分子進化学 / ゲノム機能解析 / 環境変異原 / 突然変異体 / 突然変異解析 / 疾患モデル / 化学変異原 / DNAシーケンシング / 疾患モデル動物 / ENU / 量的遺伝 / ゲノム機能 / 逆遺伝学 / マウス遺伝学 Less

The mechanisms of selection of the translation initiation codon; analysis of illegitimate translation in mutant mice created by genome editingPrincipal Investigator
- Principal Investigator
  
  牧野茂
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45010:Genetics-related
- Research Institution
  Japanese Foundation for Cancer Research
Development of comprehensive identification of spontaneous mutations based on whole genome sequencing applicable for the assessment of low-dose mutagens.
- Principal Investigator
  
  Gondo Yoichi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental impact assessment
- Research Institution
  Tokai University
Elucidation of regulatory mechanisms of GLI transcription factors in Hh signaling using mouse point mutations in SufuPrincipal Investigator
- Principal Investigator
  
  Shigeru Makino
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
High-throughput development of disease model mice by using next-generation technologies.
- Principal Investigator
  
  GONDO Yoichi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of point mutations in mouse Sufu, which mediates Hedgehog signal transduction, in tumor formationPrincipal Investigator
- Principal Investigator
  
  MAKINO Shigeru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The Institute of Physical and Chemical Research

All 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] Animal models for the study of human disease 2nd Ed (Ed by Conn, P. Michael)2017
- Author(s)
  Yoichi Gondo, Shigeru Makino, Ryutaro Fukumura
- Total Pages
  1177
- Publisher
  Academic Press, an imprint of Elsevier
- ISBN
  9780128094686
- Data Source
  KAKENHI-PROJECT-17H00789
[Journal Article] T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor2015
- Author(s)
  Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui C.C, Gondo Y
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 3 Pages: e0119455-e0119455
- DOI
  10.1371/journal.pone.0119455
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440096, KAKENHI-PROJECT-26291006, KAKENHI-PROJECT-26860196
[Journal Article] β-cateninC429S mice exibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.2014
- Author(s)
  Murata T, Ishitsuka Y, Karouji K, Kaneda H, Toki H, Nakai Y, Makino S, Fukumura R, Kotaki H, Wakana S, Noda T, Gondo Y
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 6959-6959
- DOI
  10.1038/srep06959
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25430100, KAKENHI-PROJECT-25440096
[Journal Article] Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling2012
- Author(s)
  Law KK., Makino S, Mo R, Zhang X, Puviindran V, Hui CC
- Journal Title
  
  PLoS One
  
  Volume: 7(11) Issue: 11 Pages: e50193-e50193
- DOI
  10.1371/journal.pone.0050193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240043
[Journal Article] ouse Mutagenesis and Disease Models for Neuropsychiatric Disorders2011
- Author(s)
  Gondo, Y., Murata, T., Makino, S., Fukumura, R., Ishitsuka, Y
- Journal Title
  
  Curr Top Behav Neurosci [Epub ahead of print 2011 Feb 5]
  
  Volume: 7 Pages: 1-35
- DOI
  10.1007/7854_2010_106
- ISBN
  9783642197024, 9783642197031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240043
[Journal Article] Mouse Mutagenesis and Disease Models for Neuropsychiatric Disorders.2011
- Author(s)
  Gondo Yoichi, Murata Takuya, Makino Shigeru, Fukumura Ryutaro, Ishitsuka Yuichi.
- Journal Title
  
  Curr Top Behav Neurosci Vol.7
  
  Pages: 1-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700454
[Journal Article] ENU-based gene-driven mutagenesis in the mouse : a next-generation gene-targeting system.2010
- Author(s)
  Gondo Yoichi, Fukumura Ryutaro, Murata Takuya, Makino Shigeru.
- Journal Title
  
  Experimental Animals Vol.59 5
  
  Pages: 537-548
- NAID
  130000419249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700454
[Journal Article] ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system2010
- Author(s)
  Gondo Y, Fukumura R, Murata T, Makino S
- Journal Title
  
  Exp Anim
  
  Volume: 59(5) Pages: 537-48
- NAID
  130000419249
- Data Source
  KAKENHI-PROJECT-21240043
[Journal Article] Next-generation gene targeting in the mouse for functional genomics.2009
- Author(s)
  Gondo Yoichi, Fukumura Ryutaro, Murata Takuya, Makino Shigeru.
- Journal Title
  
  BMB Reports Vol.42 6
  
  Pages: 315-323
- Data Source
  KAKENHI-PROJECT-21700454
[Journal Article] The kinesin protein Kif7 is a critical regulator of Gli transcription factors in Mammalian hedgehog signaling.2009
- Author(s)
  Cheung Helen, Zhang Xiaoyun, Ribeiro Ana, Mo Rong, Makino Shigeru, Puviindran Vijitha, Law Kelvin, Briscoe James, Hui Chi-Chung.
- Journal Title
  
  Science Signaling Vol.2 76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700454
[Journal Article] Next-generation gene targeting in the mouse for functional genomics2009
- Author(s)
  Gondo, Y., Fukumura, R., Murata, T., Makino, S
- Journal Title
  
  BMB Reports
  
  Volume: 42(6) Pages: 315-323
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] ゲノム編集による定型外翻訳発見と臨床応用や実用化への警鐘2019
- Author(s)
  牧野茂、権藤洋一
- Organizer
  日本遺伝学会第91回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] 定型外翻訳とヒト疾患：翻訳の分子機構を解析する新しい方法2019
- Author(s)
  権藤洋一、牧野茂
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06355
[Presentation] Illegitimate translation from frameshift mutations created by CRISPR-Cas9 genome-editing rescues the KO phenotype in the mouse.2019
- Author(s)
  Gondo Y, Makino S, Inoue K, Hirose M, Fukumura R, Ogura A
- Organizer
  The 13th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] 致死表現型をレスキューする定型外翻訳の解析とヒト疾患への応用2019
- Author(s)
  牧野茂、権藤洋一
- Organizer
  日本遺伝学会第91回大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06355
[Presentation] ほ乳類など産仔数の少ない生物種における遺伝的多様性産出と適応放散戦略の検証2018
- Author(s)
  権藤洋一、福村龍太郎、小瀧逸人、石塚祐一、中井祐治、牧野茂、本杉奈美、木村穣、森一樹、久原哲、豊田敦、藤山秋佐夫
- Organizer
  先進ゲノム支援合同班会議
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] 致死表現型をレスキューする定型外翻訳の遺伝学2018
- Author(s)
  牧野茂、井上貴美子、田村勝、廣瀬美智子、石塚祐一、福村龍太郎、小倉淳郎、権藤洋一
- Organizer
  モロシヌス研究会
- Data Source
  KAKENHI-PROJECT-18K06355
[Presentation] 自然発生生殖細胞系列突然変異のほ乳類の発生段階における起源2018
- Author(s)
  権藤洋一、福村龍太郎、小瀧逸人、石塚祐一、中井祐治、牧野茂、森一樹、久原哲、豊田敦、藤山秋佐夫、木村穣
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Illegitimate translation from out-of-frame alleles created by CRISPR-Cas9 rescues KO lethality.2017
- Author(s)
  Shigeru Makino, Kimiko Inoue, Masaru Tamura, Michiko Hirose, Yuichi Ishitsuka, Ryutaro Fukumura, Shigeru Wakana, Atsuo Ogura, Yoichi Gondo
- Organizer
  AMMRA and AMPC Meeting 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Mouse genetics toward functional analysis.2017
- Author(s)
  Shigeru Makino, Yoichi Gondo
- Organizer
  2017 RIKEN MARC KMPC Mouse Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] WGSを用いた近交系マウスC57BL/JJclに生じる自然発生突然変異/SNV検出と公開2017
- Author(s)
  福村龍太郎、小瀧逸人、石塚祐一、牧野茂、中井祐治、森一樹、久原哲、豊田敦、藤山秋佐夫、権藤洋一
- Organizer
  NGS現場の会第5回研究会
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] フレームシフト変異マウスを利用した翻訳開始点の解析2017
- Author(s)
  牧野茂、井上貴美子、廣瀬美智子、石塚祐一、福村龍太郎、小倉淳郎、権藤洋一
- Organizer
  第30回モロシヌス研究会
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] フレームシフト変異アレルからの定型外翻訳によるタンパク質発現2017
- Author(s)
  牧野茂、井上貴美子、廣瀬美智子、石塚祐一、福村龍太郎、小倉淳郎、権藤洋一
- Organizer
  日本ゲノム編集学会第2回大会
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Illegitimate translation revealed by CRISPR-Cas9 genome editing: The genome-edited proteins rescue the knockout phenotype.2017
- Author(s)
  Yoichi Gondo, Shigeru Makino, Kimiko Inoue, Michiko Hirose, Yuichi Ishitsuka, Ryutaro Fukumura, Atsuo Ogura
- Organizer
  The 12th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] マウスGli3ゲノム編集変異は定型外翻訳によって致死表現型をレスキューする2017
- Author(s)
  牧野茂、井上貴美子、田村勝、廣瀬美智子、石塚祐一、福村龍太郎、若菜茂晴、小倉淳郎、権藤洋一
- Organizer
  日本遺伝学会第89回大会
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Detection and analysis of spontaneous mutations in the C57BL/6JJcl strain by complete outbreeding.2017
- Author(s)
  Fukumura R, Ishitsuka Y, Makino S, Nakai Y, Mori K, Toyoda A, Kuhara S, Fujiyama A, Gondo Y
- Organizer
  The 12th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Detection and analysis of spontaneous mutations in the standard mouse strain by complete outbreeding.2017
- Author(s)
  Fukumura R, Kotaki H, Ishitsuka Y, Makino S, Nakai Y, Mori K, Toyoda A, Kuhara S, Fujiyama A, Gondo Y
- Organizer
  Advanced Geome Science International Symposium; The Start of New Genomics.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00789
[Presentation] Production of a truncated protein from the Gli3 gene with a frameshift mutation, which is introduced by the CRISPR/Cas9 system2015
- Author(s)
  Makino S, Gondo Y
- Organizer
  The 29th International Mammalian Genome Conference (IMGC2015)
- Place of Presentation
  横浜市開港記念会館・横浜市・神奈川県
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] Gli転写因子の可視化の試みー培養細胞でのGli3遺伝子の不活性化2015
- Author(s)
  牧野茂、権藤洋一
- Organizer
  第29回モロシヌス研究会
- Place of Presentation
  かんぽの宿・神戸市・兵庫県
- Year and Date
  2015-07-03
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] Gli転写因子の可視化の試み：CRISPR/CasシステムによるGli3遺伝子のノックダウン2015
- Author(s)
  牧野茂、権藤洋一
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学・仙台市・宮城県
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] フレームシフト変異下流からの翻訳再開によるGLI3タンパク質発現2015
- Author(s)
  牧野茂、福村龍太郎、権藤洋一
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会（BMB2015）
- Place of Presentation
  神戸ポートアイランド・神戸市・兵庫県
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] 内脂肪増加を示すSufu点突然変異マウスの解析2014
- Author(s)
  牧野　茂、石塚祐一、茂木浩未、福村龍太郎、村田卓也、小瀧逸人、野田哲生、権藤洋一
- Organizer
  モロシヌス研究会
- Place of Presentation
  静岡県伊豆市
- Year and Date
  2014-07-20
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] Sufu点突然変異マウスによるGli転写因子活性制御機構の解明2014
- Author(s)
  牧野　茂、Zhulyn Olena、村田卓也、福村龍太郎、石塚祐一、小瀧逸人、Hui Chi-Chung、権藤洋一
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  滋賀県長浜市
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] 成体でのHhシグナルを解析するためのSufu点突然変異マウス系統群の樹立2014
- Author(s)
  牧野　茂、石塚祐一、茂木浩未、福村龍太郎、村田卓也、小瀧逸人、野田哲生、権藤洋一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] Missense mutant mice of Sufu demarcate its regulatory actions on Gli2 and Gli32014
- Author(s)
  Shigeru Makino, Olena Zhulyn, Rong Mo, Vijitha Puviindran, Xiaoyun Zhang, Takuya Murata, Ryutaro Fukumura, Yuichi Ishitsuka, Hayato Kotaki, Daisuke Matsumaru, Shunsuke Ishii, Chi-Chung Hui, Yoichi Gondo
- Organizer
  The 2014 Hedgehog Meeting on Hedgehog Signaling in Development and Disease
- Place of Presentation
  Ann Arbor, Michigan, USA
- Year and Date
  2014-08-07
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] From monogenic to polygenic modeling of human diseases by mouse mutagenesis and next-generation sequencing (NGS)2013
- Author(s)
  Gondo Y, Fukumura R, Murata T, Makino S
- Organizer
  Joint Conference of Human Genome Meeting 2013 and 21st International Congress of Genetics. Singapore
- Place of Presentation
  Singapore
- Year and Date
  2013-04-16
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Deep sequencing of mouse exome for modeling human diseases encompassing gene-to-gene interactions. Mouse Genetics 20112012
- Author(s)
  Gondo Y, Fukumura R, Murata T, Makino S
- Organizer
  Joint Conference of the IMGS, CTC, and GSA
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 単一遺伝子形質と量的形質のあいだをつなぐ新しい変異マウスライブラリーの開発と利用公開2012
- Author(s)
  権藤洋一,福村龍太郎,村田卓也,牧野茂
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都, 日本
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Evaluation of deep exome sequencing for the discovery of novel SNPs and de novo mutations by using the mouse model2012
- Author(s)
  Gondo Y, Fukumura R, Murata T, Makino S
- Organizer
  X-Gen Congress and Expo
- Place of Presentation
  San Diego, USA. March (Oxford Nanopore Poster Award 受賞)
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Complex traits とENU mutagenesis; Reverse Genetics からForward へ2012
- Author(s)
  村田卓也, 福村龍太郎, 牧野茂, 権藤洋一
- Organizer
  平成24 年度国立遺伝学研究所研究会「マウスForward Genetics の新潮流:Common diseases(complex traits)のマウス遺伝学」
- Place of Presentation
  三島市招待講演
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Epithelial Organizations were defected during seminal vesicle and vaginal formation in a new Ctnnb1 infertile model mouse2012
- Author(s)
  Murata T, Toki H, Ishitsuka Y, Kaneda H, Makino S, Fukumura R, Wakana S, Noda T, Gondo Y
- Organizer
  The 26th International Mammalian Genome Conference (IMGC2012)
- Place of Presentation
  St. Pete Beach USA 口演採択演題
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Sufu点突然変異マウスの表現型解析を基にしたGli転写因子の活性調節機構の解析2011
- Author(s)
  牧野茂, 他
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Sufu点突然変異マウスの解析から明らかとなったGli3転写因子の活性調節機構2011
- Author(s)
  牧野茂, 他
- Organizer
  第58回日本実験動物学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] ENU-induced mutation in mouse Sufu caused misregulation of the repressor form of the Gli3 transcription factor2011
- Author(s)
  Makino S, et al
- Organizer
  Mouse Genetics 2011, Joint Conference of the IMGS, CTC, and GSA
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Sufu点突然変異マウスの解析から見えて来たGli3転写因子の活性調節機構2011
- Author(s)
  牧野茂, 他
- Organizer
  第25回モロシヌス研究会
- Place of Presentation
  新潟
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Sufuミスセンス変異マウス系統を用いたSufuタンパク質のThr^<396>残基依存的なGli3^<REP>転写因子の分解調節機構2011
- Author(s)
  牧野茂, 他
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] ENU誘発点突然変異マウスを用いた細胞内ヘッジホグシグナル伝達機構の解析。2010
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, Hui Chi-Chung, 山田源, 権藤洋一
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都日本
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ヘッジホグシグナル伝達を仲介するSufuの活性調節機構の解析2010
- Author(s)
  牧野茂
- Organizer
  モロシヌス研究会
- Place of Presentation
  南阿蘇村
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ENU誘発点突然変異マウスを用いた細胞内ヘッジホグシグナル伝達機構の解析2010
- Author(s)
  牧野茂
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都市
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] 機能低下型Sufu点突然変異マウスを用いた細胞内ヘッジホグシグナル伝達機構の解析2010
- Author(s)
  牧野茂
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] RIKEN next-generation gene-targeting system with the ENU mutant mouse library.2010
- Author(s)
  牧野茂, ほか
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] New sterile model mouse from RIKEN ENU-based gene-driven mutagenesis2010
- Author(s)
  Murata, T., Makino, S., Fukumura, R., Gondo, Y
- Organizer
  The 24th International Mammalian Genome Conference (IMGC2010)
- Place of Presentation
  Crete, Greece
- Year and Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] RIKEN next-generation gene-targeting system with the ENU mutant mouse library.2010
- Author(s)
  Makino Shigeru, Fukumura Ryutaro, Murata Takuya, Ishitsuka Yuichi, Kotaki Hayato, Gondo Yoichi.
- Organizer
  4th AFLAS Congress Meeting/5th AMMRA Annual Meeting/11th CSLAS Annual Meeting
- Place of Presentation
  Taipei Taiwan
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] RIKEN NEXT-GENERATION GENE-TARGETING SYSTEM WITH THE ENU MUTANT MOUSE LIBRARY2010
- Author(s)
  Shigeru Makino
- Organizer
  The 4th AFLAS Congress Meeting & 5th AMMRA Meeting
- Place of Presentation
  Taipei
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグシグナル伝達系のマウス発生遺伝学:II.Sufu変異系統の表現型解析2010
- Author(s)
  牧野茂, 他
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 次世代版ジーンターゲッティングシステムに基づく遺伝子間相互作用解明のためのモデルマウスリソース2010
- Author(s)
  権藤洋一、福村龍太郎、村田卓也、牧野茂
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグシグナル伝達系のマウス発生遺伝学:II. Sufu変異系統の表現型解析。2010
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, 石塚祐一, 小瀧逸人, 権藤洋一
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌日本
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグ(Hh)シグナル伝達系のマウス発生遺伝学:II.Sufu変異系統の表現型解析2010
- Author(s)
  牧野茂
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌市
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Sufu点突然変異マウス系統群を用いた細胞内ヘッジホグシグナル伝達機構の解明。2010
- Author(s)
  牧野茂
- Organizer
  平成21年度採択研究奨励ファンド・連携の芽ファンド成果報告会
- Place of Presentation
  和光日本
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ヘッジホグシグナル伝達を仲介するSufuの活性調節機構の解析。2010
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, 石塚祐一, 小瀧逸人, 権藤洋一
- Organizer
  第24回モロシヌス研究会
- Place of Presentation
  熊本県南阿蘇村日本
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] 機能低下型Sufu点突然変異マウスを用いた細胞内ヘッジホグシグナル伝達機構の解析。2010
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, 石塚祐一, 小瀧逸人, Hui Chi-Chung, 権藤洋一
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸日本
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ヘッジホグシグナル伝達を仲介するSufuの活性調節機構の解析2010
- Author(s)
  牧野茂, 他
- Organizer
  第24回モロシヌス研究会
- Place of Presentation
  熊本県南阿蘇村
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] ENU誘発点突然変異マウスを用いた細胞内ヘッジホグシグナル伝達機構の解析2010
- Author(s)
  牧野茂, ほか
- Organizer
  第57回日本実験動物学会総会
- Place of Presentation
  京都
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] RIKEN next-generation gene-targeting system with the ENU mutant mouse library.2010
- Author(s)
  Makino, S., et al.
- Organizer
  The 4th AFLAS Congress Meeting/5th AMMRA Annual Meeting/11th CSLAS Annual Meeting
- Place of Presentation
  台湾、台北
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグシグナル伝達系のマウス発生遺伝学: I.Sufu変異系統の樹立2009
- Author(s)
  牧野茂
- Organizer
  日本遺伝学会第81回大会
- Place of Presentation
  松本
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ENU誘発点突然変異マウスを用いたヘッジホグシグナル伝達系の発生遺伝学的解析2009
- Author(s)
  牧野茂
- Organizer
  第23回モロシヌス研究会
- Place of Presentation
  滋賀県守山
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Characterization of allelic series of mouse point mutations in a hedgehog signaling gene, Sufu, from the ENU mutant mouse library2009
- Author(s)
  牧野茂
- Organizer
  The 23rd International Mammalian Genome Conference
- Place of Presentation
  La Jolla, USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグシグナル伝達系のマウス発生遺伝学:I.Sufu 変異系統の樹立2009
- Author(s)
  牧野茂
- Organizer
  日本遺伝学会第81回大会
- Place of Presentation
  (信州大学)松本
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Functional genomics with next-generation gene-targeting2009
- Author(s)
  Gondo, Y., Fukumura, R., Murata, T., Makino, S. (2009)
- Organizer
  The 8th International Workshop on Advanced Genomics Expansion of Genome Science (AGW2009)
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 次世代ジーンターゲッティングに基づくヘッジホグシグナル伝達系のマウス発生遺伝学:I. Sufu変異系統の樹立。2009
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, 小瀧逸人, Hui Chi-chung, 権藤洋一
- Organizer
  日本遺伝学会第81回大会
- Place of Presentation
  松本日本
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Identification and characterization of mouse mutations in Hedgehog signaling genes identified in the ENU mutant mouse library2009
- Author(s)
  牧野茂
- Organizer
  Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference Mouse Genetics & Genomics : Development Disease
- Place of Presentation
  Hinxton, UK
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] ENU誘発点突然変異マウスを用いたヘッジホグシグナル伝達系の発生遺伝学的解析。2009
- Author(s)
  牧野茂, 村田卓也, 福村龍太郎, 権藤洋一
- Organizer
  第23回モロシヌス研究会
- Place of Presentation
  守山日本
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Characterization of allelic series of mouse point mutations in a hedgehog signaling gene, Sufu, from the ENU mutant mouse library2009
- Author(s)
  牧野茂
- Organizer
  23rd International Mammalian Genome Conference
- Place of Presentation
  La Jolla, USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Identification and characterization of mouse mutations in Hedgehog signaling genes identified in the ENU mutant mouse library.2009
- Author(s)
  Makino Shigeru, Fukumura Ryutaro, Murata Takuya, Gondo Yoichi.
- Organizer
  Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference Mouse Genetics&Genomics : Development&Disease
- Place of Presentation
  Hinxton UK
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] ENU誘発点突然変異マウスを用いたヘッジホグシグナル伝達系の発生遺伝学的解析2009
- Author(s)
  牧野茂
- Organizer
  第23回モロシヌス研究会
- Place of Presentation
  守山
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Characterization of allelic series of mouse point mutations in a hedgehog signaling gene, Sufu, from the ENU mutant mouse library.2009
- Author(s)
  Makino Shigeru, Fukumura Ryutaro, Murata Takuya, Gondo Yoichi.
- Organizer
  23rd International Mammalian Genome Conference La
- Place of Presentation
  Jolla USA
- Year and Date
  2009-11-03
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Identification and characterization of mouse mutations in Hedgehog signaling genes identified in the ENU mutant mouse library2009
- Author(s)
  牧野茂
- Organizer
  Joint Cold Spring Harbor Laboratory/Wellcome Trust Conference Mouse Genetics \& Genomics : Development \& Disease
- Place of Presentation
  Hinxton, UK
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-21700454
[Presentation] Hhシグナル伝達系の点突然変異マウスを用いた疾患モデル開発の試み
- Author(s)
  牧野　茂、村田卓也、福村龍太郎、石塚祐一、小瀧逸人、権藤洋一
- Organizer
  日本実験動物学会
- Place of Presentation
  茨城県つくば市つくば国際会議場
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] 複数のSufu点突然変異アレルを用いたヘッジホグシグナル伝達系の解析
- Author(s)
  牧野　茂、村田卓也、福村龍太郎、石塚祐一、小瀧逸人、権藤洋一
- Organizer
  日本遺伝学会
- Place of Presentation
  神奈川県横浜市慶応義塾大学日吉キャンパス
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] 点突然変異系統間交配を用いたヘッジホグシグナル伝達系の解析
- Author(s)
  牧野　茂、村田卓也、福村龍太郎、石塚祐一、小瀧逸人、権藤洋一
- Organizer
  モロシヌス研究会
- Place of Presentation
  茨城県つくば市理化学研究所バイオリソースセンター・筑波山江戸家
- Data Source
  KAKENHI-PROJECT-25440096
[Presentation] Sufu点突然変異マウスを用いた抑制型転写因子Gli3REPの制御機構の解析
- Author(s)
  牧野茂　他
- Organizer
  第26回モロシヌス研究会
- Place of Presentation
  東京都文京区
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] Sufu点突然変異マウスの発生遺伝学的解析によるGli転写因子の活性調節機構
- Author(s)
  牧野茂　他
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21240043
[Presentation] 複数のENU誘発マウス点突然変異系統を活用したヘッジホグシグナル伝達系の機能解析
- Author(s)
  牧野　茂、村田卓也、福村龍太郎、石塚祐一、小瀧逸人、権藤洋一
- Organizer
  日本分子生物学会
- Place of Presentation
  兵庫県神戸市神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25440096

1. GONDO Yoichi (40225678)

# of Collaborated Projects: 5 results

# of Collaborated Products: 55 results
2. FUKUMURA Ryutaro (90392240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
3. MURATA Takuya (70305001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. KIKUCHI Jun (00321753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAWAI Jun (30391923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木村穣 (10146706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HUI Chi-Chung

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

MAKINO Shigeru 牧野 茂

牧野 茂 マキノ シゲル

Research Projects

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Co-Researchers

The mechanisms of selection of the translation initiation codon; analysis of illegitimate translation in mutant mice created by genome editingPrincipal Investigator

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Development of comprehensive identification of spontaneous mutations based on whole genome sequencing applicable for the assessment of low-dose mutagens.

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Elucidation of regulatory mechanisms of GLI transcription factors in Hh signaling using mouse point mutations in SufuPrincipal Investigator

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High-throughput development of disease model mice by using next-generation technologies.

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Analysis of point mutations in mouse Sufu, which mediates Hedgehog signal transduction, in tumor formationPrincipal Investigator

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[Book] Animal models for the study of human disease 2nd Ed (Ed by Conn, P. Michael)2017

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[Journal Article] T396I Mutation of Mouse Sufu Reduces the Stability and Activity of Gli3 Repressor2015

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[Journal Article] β-cateninC429S mice exibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.2014

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[Journal Article] Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling2012

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[Journal Article] ouse Mutagenesis and Disease Models for Neuropsychiatric Disorders2011

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[Journal Article] Mouse Mutagenesis and Disease Models for Neuropsychiatric Disorders.2011

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[Journal Article] ENU-based gene-driven mutagenesis in the mouse : a next-generation gene-targeting system.2010

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NAID

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[Journal Article] ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system2010

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NAID

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[Journal Article] Next-generation gene targeting in the mouse for functional genomics.2009

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MAKINO Shigeru 牧野茂

牧野茂マキノシゲル