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Kuno Atsushi  久野 篤史

… Alternative Names

KUNO Atsushi  久野 篤史

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Researcher Number 30468079
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6873-1297
Affiliation (Current) 2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 札幌医科大学, 医学部, 教授
2018 – 2021: 札幌医科大学, 医学部, 准教授
2017: 札幌医科大学, 医学部, 講師
2012: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47040:Pharmacology-related / General pharmacology
Except Principal Investigator
Basic Section 53020:Cardiology-related / Basic Section 47040:Pharmacology-related / General pharmacology
Keywords
Principal Investigator
オートファジー / マイトファジー / 心不全 / SIRT1 / RIPK3 / ネクロプトーシス / 糖尿病 / 急性腎障害 / mTOR / リソソーム / オートファゴソーム … More
Except Principal Investigator
… More 心不全 / SIRT1 / サルコペニア / 代謝 / BCKDH / 分岐鎖アミノ酸 / AMP deaminase / アミノ酸 / 心筋代謝 / 糖尿病 / mTOR / 拡張型心筋症 / ネクロプトーシス / 細胞死 / ミトコンドリア / オートファジー / 酢酸 / MLKL / 骨格筋 / 老化 / diabetic cardiomyopathy / mitochondria / MAM / AMPD3 / ミトコンドリア近接小胞体膜 / 小胞体 / AMPデアミナーゼ / ミトコンドリア小胞体近接領域 / AMPデミナーゼ / 糖尿病性心筋症 / 核酸 / 心筋細胞 / ネクローシス / マイトファジー / 筋ジストロフィー / NGF / PC12 / resveratrol / NAD / 分化 / ユビキチン化 / p300 / メラノーマ / 神経堤 / deacetylase / Notch / PIP3 / メラノーマ細胞 / 神経細胞 / lamellipodia / neurite / 細胞移動 / 長寿遺伝子 / サーチュイン Less
  • Research Projects

    (11 results)
  • Research Products

    (113 results)
  • Co-Researchers

    (17 People)
  •  Roles of interplay between autophagy and necroptosis in aggravation of acute kidney injury by diabetesPrincipal Investigator

    • Principal Investigator
      久野 篤史
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  心筋分岐鎖アミノ酸代謝を標的とした心不全治療の開発

    • Principal Investigator
      神津 英至
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Sapporo Medical University
  •  蛋白アセチル化修飾を標的としたサルコペニア発症機序の解明と治療法開発

    • Principal Investigator
      細田 隆介
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  ネクロプトーシス実行因子MLKLを標的とした心不全治療の開発

    • Principal Investigator
      矢野 俊之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Sapporo Medical University
  •  Mechanisms underlying regulation of AMP deaminase activity and its involvement in the pathophysiology of diabetic cardiomyopathy

    • Principal Investigator
      Tanno Masaya
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Sapporo Medical University
  •  Mechanisms of dysregulation of autophagy in heart failurePrincipal Investigator

    • Principal Investigator
      Kuno Atsushi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  Development of novel therapy for heart failure targeting the crosstalk between amino acid and nucleotide metabolism

    • Principal Investigator
      Kouzu Hidemichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Sapporo Medical University
  •  Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.

    • Principal Investigator
      Hosoda Ryusuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Sapporo Medical University
  •  Necroptosis-tartgeted therapy for heart failure

    • Principal Investigator
      Yano Toshiyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Sapporo Medical University
  •  Novel role of SIRT1 in regulation of autophagy and its role in heart failurePrincipal Investigator

    • Principal Investigator
      Kuno Atsushi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Sapporo Medical University
  •  Functional roles of SIRT1 in the differentiation of neural cells

    • Principal Investigator
      HORIO Yoshiyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Sapporo Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2013 2012 2011 2010

All Journal Article Presentation Book Patent

  • [Book] 「レスベラトロールによる筋ジストロフィー治療の試み」レスベラトロールの基礎と応用(坪田一男監修)2012

    • Author(s)
      久野篤史、堀尾嘉幸
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy2024

    • Author(s)
      Nakashima Ryuta、Hosoda Ryusuke、Tatekoshi Yuki、Iwahara Naotoshi、Saga Yukika、Kuno Atsushi
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 1365-1365

    • DOI

      10.1038/s41598-024-51746-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K19373, KAKENHI-PROJECT-22K06632
  • [Journal Article] Role of AMP deaminase in diabetic cardiomyopathy2024

    • Author(s)
      Miura T, Kouzu H, Tanno M, Tatekoshi Y, Kuno A
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: - Issue: 12 Pages: 3195-3211

    • DOI

      10.1007/s11010-024-04951-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K07481, KAKENHI-PROJECT-21K08035
  • [Journal Article] Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts.2023

    • Author(s)
      Ino S, Yano T, Kuno A, Tanno M, Kouzu H, Sato T, Yamashita T, Ohwada W, Osanami A, Ogawa T, Toda Y, Shimizu M, Miura T.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 151 Issue: 2 Pages: 134-143

    • DOI

      10.1016/j.jphs.2022.12.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08035, KAKENHI-PROJECT-22K08189
  • [Journal Article] Downregulation of extramitochondrial <scp>BCKDH</scp> and its uncoupling from <scp>AMP</scp> deaminase in type 2 diabetic <scp>OLETF</scp> rat hearts2023

    • Author(s)
      Ogawa Toshifumi、Kouzu Hidemichi、Osanami Arata、Tatekoshi Yuki、Sato Tatsuya、Kuno Atsushi、Fujita Yugo、Ino Shoya、Shimizu Masaki、Toda Yuki、Ohwada Wataru、Yano Toshiyuki、Tanno Masaya、Miki Takayuki、Miura Tetsuji
    • Journal Title

      Physiological Reports

      Volume: 11 Issue: 4

    • DOI

      10.14814/phy2.15608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-20K08452
  • [Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023

    • Author(s)
      Hosoda Ryusuke, Nakashima Ryuta, Yano Masaki, Iwahara Naotoshi, Asakura Seidai, Nojima Iyori, Saga Yukika, Kunimoto Risa, Horio Yoshiyuki, Kuno Atsushi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 152 Issue: 2 Pages: 112-122

    • DOI

      10.1016/j.jphs.2023.04.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06632, KAKENHI-PROJECT-20K07068
  • [Journal Article] Adenosine monophosphate deaminase in the endoplasmic reticulummitochondria interface promotes mitochondrial Ca2+ overload in type 2 diabetes rat hearts.2023

    • Author(s)
      Osanami A, Sato T, Toda Y, Shimizu M, Kuno A, Kouzu H, Yano T, Ohwada W, Ogawa T, Miura T, Tanno M.
    • Journal Title

      J Diabetes Investig

      Volume: 14 Issue: 4 Pages: 560-569

    • DOI

      10.1111/jdi.13982

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-21K08035, KAKENHI-PROJECT-21K08110
  • [Journal Article] Activation of SIRT1 promotes membrane resealing via cortactin2022

    • Author(s)
      Iwahara Naotoshi、Azekami Kuya、Hosoda Ryusuke、Nojima Iyori、Hisahara Shin、Kuno Atsushi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 15328-15328

    • DOI

      10.1038/s41598-022-19136-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07541, KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
  • [Journal Article] SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX2022

    • Author(s)
      Kuno Atsushi、Hosoda Ryusuke、Tsukamoto Miki、Sato Tatsuya、Sakuragi Hiromi、Ajima Nami、Saga Yukika、Tada Kouhei、Taniguchi Yoshiki、Iwahara Naotoshi、Horio Yoshiyuki
    • Journal Title

      Cardiovascular Research

      Volume: 118 Issue: 17 Pages: 3360-3373

    • DOI

      10.1093/cvr/cvac026

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
  • [Journal Article] Elevated circulating level of β-aminoisobutyric acid (BAIBA) in heart failure patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitors2022

    • Author(s)
      Katano Satoshi、Yano Toshiyuki、Kouzu Hidemichi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Ohori Katsuhiko、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Katayose Masaki、Sato Tatsuya、Kuno Atsushi、Furuhashi Masato
    • Journal Title

      Cardiovascular Diabetology

      Volume: 21 Issue: 1 Pages: 285-285

    • DOI

      10.1186/s12933-022-01727-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-20K19313, KAKENHI-PROJECT-18K17677
  • [Journal Article] Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy2022

    • Author(s)
      Fujita Y, Yano T, Kanamori H, Nagahara D, Muranaka A, Kouzu H, Mochizuki A, Koyama M, Nagano N, Fujito T, Nishikawa R, Kamiyama N, Tanaka M, Kuno A, Tanno M, Miura T
    • Journal Title

      ESC Heart Failure

      Volume: 9 Issue: 5 Pages: 3435-3451

    • DOI

      10.1002/ehf2.14059

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08035, KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-22K08313
  • [Journal Article] Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts2022

    • Author(s)
      Iyori Nojima, Ryusuke Hosoda, Yuki Toda, Yoshiki Saito, Naohiro Ueda, Kouhei Horimoto, Naotoshi Iwahara, Yoshiyuki Horio, Atsushi Kuno
    • Journal Title

      Aging

      Volume: 14 Issue: 7 Pages: 2966-2988

    • DOI

      10.18632/aging.203999

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K17806, KAKENHI-PROJECT-20K07068
  • [Journal Article] Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury2021

    • Author(s)
      Sugawara Hirohito、Moniwa Norihito、Kuno Atsushi、Ohwada Wataru、Osanami Arata、Shibata Satoru、Kimura Yukishige、Abe Koki、Gocho Yufu、Tanno Masaya、Miura Tetsuji
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 145 Issue: 2 Pages: 187-197

    • DOI

      10.1016/j.jphs.2020.12.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-18K08079
  • [Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload2021

    • Author(s)
      Igaki Yusuke、Tanno Masaya、Sato Tatsuya、Kouzu Hidemichi、Ogawa Toshifumi、Osanami Arata、Yano Toshiyuki、Kuno Atsushi、Miki Takayuki、Nakamura Takashi、Miura Tetsuji
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 154 Pages: 21-31

    • DOI

      10.1016/j.yjmcc.2021.01.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08522, KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-21K08110
  • [Journal Article] Cellular effects of resveratrol in health and disease2021

    • Author(s)
      久野 篤史、堀尾 嘉幸
    • Journal Title

      生化学

      Volume: 93 Issue: 1 Pages: 100-108

    • DOI

      10.14952/SEIKAGAKU.2021.930100

    • ISSN
      0037-1017
    • Year and Date
      2021-02-25
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Journal Article] Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model2021

    • Author(s)
      Shibata Satoru、Moniwa Norihito、Kuno Atsushi、Kimura Ayumu、Ohwada Wataru、Sugawara Hirohito、Gocho Yufu、Tanaka Marenao、Yano Toshiyuki、Furuhashi Masato、Tanno Masaya、Miki Takayuki、Miura Tetsuji
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: Online ahead of print Issue: 7 Pages: 708-717

    • DOI

      10.1007/s10157-021-02048-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-20K08913, KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-19K08708, KAKENHI-PROJECT-21K08035
  • [Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020

    • Author(s)
      Hosoda Ryusuke、Hamada Hiroki、Uesugi Daisuke、Iwahara Naotoshi、Nojima Iyori、Horio Yoshiyuki、Kuno Atsushi
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 376 Issue: 3 Pages: 385-396

    • DOI

      10.1124/jpet.120.000096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Journal Article] Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats2020

    • Author(s)
      Kuno A, Kimura Y, Mizuno M, Oshima H, Sato T, Moniwa N, Tanaka M, Yano T, Tanno M, Miki T, Miura T.
    • Journal Title

      Sci Rep

      Volume: 29 Issue: 1 Pages: 7238-7238

    • DOI

      10.1038/s41598-020-64380-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-19K08708
  • [Journal Article] Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-12020

    • Author(s)
      Ohwada W, Tanno M, Yano T, Ong SB, Abe K, Sato T, Kuno A, Miki T, Sugawara H, Igaki Y, Miura T.
    • Journal Title

      Biochim Biophys Acta Mol Basis Dis

      Volume: 1866 Issue: 10 Pages: 165851-165851

    • DOI

      10.1016/j.bbadis.2020.165851

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-18K08079
  • [Journal Article] mTORC1 Inhibition Attenuates Necroptosis Through RIP1 Inhibition-Mediated TFEB Activation2019

    • Author(s)
      Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T.
    • Journal Title

      Biochim Biophys Acta Mol Basis Dis .

      Volume: 1865 Issue: 12 Pages: 165552-165552

    • DOI

      10.1016/j.bbadis.2019.165552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-19K08544
  • [Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019

    • Author(s)
      Fujiwara Daisuke、Iwahara Naotoshi、Sebori Rio、Hosoda Ryusuke、Shimohama Shun、Kuno Atsushi、Horio Yoshiyuki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 6 Pages: e0218329-e0218329

    • DOI

      10.1371/journal.pone.0218329

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
  • [Journal Article] Canagliflozin, a sodium-glucose cotransporter-2 inhibitor, normalizes renal susceptibility to type?1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats2019

    • Author(s)
      Kimura Yukishige、Kuno Atsushi、Tanno Masaya、Sato Tatsuya、Ohno Kouhei、Shibata Satoru、Nakata Kei、Sugawara Hirohito、Abe Koki、Igaki Yusuke、Yano Toshiyuki、Miki Takayuki、Miura Tetsuji
    • Journal Title

      Journal of Diabetes Investigation

      Volume: in Press Issue: 4 Pages: 933-946

    • DOI

      10.1111/jdi.13009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16016, KAKENHI-PROJECT-19K08544
  • [Journal Article] Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats2018

    • Author(s)
      Oshima Hiroto、Miki Takayuki、Kuno Atsushi、Mizuno Masashi、Sato Tatsuya、Tanno Masaya、Yano Toshiyuki、Nakata Kei、Kimura Yukishige、Abe Koki、Ohwada Wataru、Miura Tetsuji
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 368 Issue: 3 Pages: 524-534

    • DOI

      10.1124/jpet.118.253666

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16016, KAKENHI-PROJECT-19K08544
  • [Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018

    • Author(s)
      Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 15555-15555

    • DOI

      10.1038/s41598-018-33930-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
  • [Journal Article] Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.2018

    • Author(s)
      Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y.
    • Journal Title

      Oxid Med Cell Longev.

      Volume: 2018 Issue: 1 Pages: 9179270-9179270

    • DOI

      10.1155/2018/9179270

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
  • [Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein.2013

    • Author(s)
      Kuno A et al.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 8 Pages: 5963-5972

    • DOI

      10.1074/jbc.m112.392050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
  • [Journal Article] Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress2013

    • Author(s)
      Hosoda R, Kuno A, Hori YS, Ohtani K, Wakamiya N, Oohori A, Hamada H, Horio Y
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 344 Pages: 124-132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein2013

    • Author(s)
      Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
    • Journal Title

      J. Biol. Chem

      Volume: 288 Pages: 5963-5972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Emerging beneficial roles of sirtuins in heart failure2012

    • Author(s)
      Tanno M, Kuno A, Horio Y, Miura T
    • Journal Title

      Basic Res Cardiol

      Volume: 107 Pages: 273-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] レスベラトロールの筋肉・神経疾患への応用2012

    • Author(s)
      堀尾嘉幸、久野篤史
    • Journal Title

      Anti-aging Medicine (アンチ・エイジング医学)

      Volume: Vol 8 Pages: 906-912

    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Cellular and molecular effects of sirtuins in health and disease2011

    • Author(s)
      Horio Y, Hayashi T, Kuno A, Kunimoto R
    • Journal Title

      Clin Sci

      Volume: 121 Pages: 191-203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy2011

    • Author(s)
      Hori SY , Kuno A, Hosoda R, Tanno M, MiuraT, Shimamoto K and Horio Y
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 338 Pages: 784-794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Cellular and molecular effects of sirtuins in health and disease.2011

    • Author(s)
      Horio Y, Hayashi T, Kuno A, Kunimoto R.
    • Journal Title

      Clin.Sci.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growthfactor-induced neurite outgrowth in PC12 cells2010

    • Author(s)
      Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y
    • Journal Title

      FEBS Lett

      Volume: 584 Pages: 2821-2826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells.2010

    • Author(s)
      Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 2821-2826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Patent] 筋ジストロフィーを処置するための組成物2011

    • Inventor(s)
      堀尾嘉幸、堀佑輔、久野篤史
    • Industrial Property Rights Holder
      堀尾嘉幸、堀佑輔、久野篤史
    • Filing Date
      2011-09-13
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Patent] 筋ジストロフィーを処置するための組2011

    • Inventor(s)
      堀尾嘉幸、久野篤史、堀佑輔権
    • Industrial Property Rights Holder
      札幌医科大学
    • Filing Date
      2011-09-14
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Patent] 筋ジストロフィーを処置するための組成物2010

    • Inventor(s)
      堀尾嘉幸、堀佑輔、久野篤史
    • Industrial Property Rights Holder
      札幌医科大学
    • Industrial Property Number
      2010-205453
    • Filing Date
      2010-09-14
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Downregulation of BCKDH activity and uncoupling from AMP deaminase underlie substrate inflexibility in type 2 diabetic hearts2023

    • Author(s)
      Ogawa T, Kouzu H, Osanami A, Shimizu M, Toda Y, Ohwada W, Sato T, Yano T, Kuno A, Tanno M, Miura T, Furuhashi M
    • Organizer
      第87回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Suppression of autophagy contributes to enhanced necroptosis signaling in diabetic kidney after ischemia-reperfusion.2023

    • Author(s)
      久野 篤史
    • Organizer
      第97回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-23K06152
  • [Presentation] SIRT1, a protein deacetylase, promotes autophagy/mitophagy by regulating autophagosome-lysosome fusion in the cardiomyocyte.2023

    • Author(s)
      久野篤史
    • Organizer
      第87回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K06632
  • [Presentation] 虚血再灌流後の糖尿病腎ではオートファジーの抑制がネクロプトーシスシグナルの亢進に寄与する2023

    • Author(s)
      久野篤史
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K06632
  • [Presentation] SIRT1, a protein deacetylase, promotes autophagy/mitophagy by regulating autophagosome-lysosome fusion in the cardiomyocyte.2023

    • Author(s)
      久野 篤史
    • Organizer
      第87回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes in Diabetic Hearts Lowers the Threshold for Mitochondrial Permeability Transition2022

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Toda Y, Miura T.
    • Organizer
      第86回 日本循環器学会 学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Novel Role of Cardiac AMP Deaminase in Extramitochondrial BCAA Metabolism: A Potential Therapeutic Target for Lipotoxicity in Diabetic Hearts2022

    • Author(s)
      Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Sato T, Yano T, Miura T, Tanno M.
    • Organizer
      第86回 日本循環器学会 学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] SIRT1はヒストンH2AXを脱アセチル化してDNA損傷反応を介することによりドキソルビシンから心筋細胞を保護する2022

    • Author(s)
      久野 篤史
    • Organizer
      日本薬理学会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] レスベラトロールはオートTreatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.ファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2022

    • Author(s)
      Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] ニコチンアミド・モノヌクレオチドはドキソルビシンによる心毒性や筋萎縮を抑制する2022

    • Author(s)
      久野 篤史
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Enhanced nuclear localization of MLKL promotes necroptosis of cardiomyocytes and predicts prognosis in dilated cardiomyopathy2022

    • Author(s)
      Toshiyuki Yano, Yugo Fujita, Shoya Ino, Wataru Ohwada, Hidemichi Kouzu, Atsushi Kuno, Masaya Tanno, Masato Furuhashi, Tetsuji Miura
    • Organizer
      日本循環器学会
    • Data Source
      KAKENHI-PROJECT-22K08189
  • [Presentation] ドキソルビシンによる臓器毒性はニコチンアミド・モノヌクレオチドにより軽減する2022

    • Author(s)
      久野 篤史
    • Organizer
      第73回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] SGLT2阻害薬による心保護効果における飢餓代謝の役割2022

    • Author(s)
      神津 英至, 小川 俊史, 久野 篤史, 丹野 雅也, 矢野 俊之, 三木 隆幸, 三浦 哲嗣
    • Organizer
      第26回日本心不全学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes in Diabetic Hearts Lowers the Threshold for Mitochondrial Permeability Transition.2022

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Toda Y, Miura T.
    • Organizer
      第86回日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-21K08110
  • [Presentation] Upregulated AMP deaminase in mitochondria-associated ER membranes in diabetic hearts lowers the threshold for mitochondrial permeability transition.2022

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T and Miura T
    • Organizer
      日本循環器学会
    • Data Source
      KAKENHI-PROJECT-21K08110
  • [Presentation] SIRT1 mediates histone H2AX Ser139 phosphorylation and DNA repair via deacetylating H2AX at Lys5.2021

    • Author(s)
      久野篤史
    • Organizer
      第43回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes and Cytosol Distinctively Contributes to Pressure Overload-induced Cardiac Dysfunction in Diabetic Hearts.2021

    • Author(s)
      Tanno M, Osanami A, Kouzu H, Ogawa T, Kuno A, Miura T.
    • Organizer
      日本循環器学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K08110
  • [Presentation] Intracellular localization of AMP deaminase and its novel role in BCAA and lipid metabolism in diabetic cardiomyopathy.2021

    • Author(s)
      Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Oshima H, Mizuno M, Kuno A, Fujita Y, Ino S, Shimizu M, Ohwada W, Sato T, Yano T, Tanno M, Miura T.
    • Organizer
      ESC congress(国際学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] レスベラトロールはオートファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2021

    • Author(s)
      細田 隆介、久野 篤史、中島 龍汰、朝倉 聖大、岩原 直敏、野島 伊世里、國本 梨沙、堀尾 嘉幸
    • Organizer
      第72回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Intracellular Localization of AMP Deaminase and a Role of Cytosolic AMPD in XOR-mediated ROS Production2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T
    • Organizer
      第85回 日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] レスベラトロールは加齢による筋委縮と筋機能障害を軽減する2021

    • Author(s)
      細田 隆介, 久野 篤史, 朝倉 聖大, 岩原 直敏, 野島 伊世里, 國本 梨沙, 堀尾 嘉幸
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Role of AMPD3 in Mitochondria-associated ER Membranes in Regulation of Threshold for Mitochondrial Permeability Transition2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T
    • Organizer
      第85回 日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Novel role of AMP deaminase in cardiac branched-chain amino acid metabolism: A potential therapeutic target for diabetic cardiomyopathy.2021

    • Author(s)
      Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Mizuno M, Kuno A, Fujita Y, Ino S, Shimizu M, Ohwada W, Sato T, Yano T, Miura T, Tanno M.
    • Organizer
      第25回 日本心不全学会 学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T and Miura T
    • Organizer
      日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-21K08110
  • [Presentation] SIRT1 protects the heart against doxorubicin induced cardiotoxicity by mediating the DNA damage response via deacetylation of histone H2AX.2021

    • Author(s)
      Atsushi Kuno
    • Organizer
      ESC Congress 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Deacetylation of Histone H2AX by Sirt1 Regulates DNA Damage Response and Protects Cardiomyocytes Against Doxorubicin-Induced Injury2021

    • Author(s)
      Atsushi Kuno
    • Organizer
      AHA Scientific Sessions 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] レスベラトロールは加齢による筋委縮を抑制し運動機能を維持する2021

    • Author(s)
      Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
    • Organizer
      第43回分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] The threshold for mitochondrial permeability transition is reduced by upregulated AMP deaminase in mitochondria-associated ER membranes in type 2 diabetic hearts.2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T.
    • Organizer
      第5回 日本循環器学会 基礎研究フォーラム(BCVR)
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T and Miura T.
    • Organizer
      American Heart Association scientific session
    • Data Source
      KAKENHI-PROJECT-21K08110
  • [Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T and Miura T.
    • Organizer
      AHA Scientific Sessions(国際学会)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] SIRT1はヒストンH2AXを脱アセチル化することによりドキソルビシンによる心筋細胞障害に対して保護的に作用する2021

    • Author(s)
      久野 篤史
    • Organizer
      第72回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] AMP deaminase in mitochondria-associated ER membranes contributes to reduction of the threshold for mitochondrial permeability transition in type 2 diabetic hearts.2021

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Sato T, Miura T.
    • Organizer
      CVMW2021 心血管代謝週間
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Upregulated AMP Deaminase in Mitochondria-associated ER Membranes and Cytosol Distinctively Contributes to Pressure Overload-induced Cardiac Dysfunction in Diabetic Hearts2021

    • Author(s)
      Tanno M, Osanami A, Kouzu H, Ogawa T, Kuno A, Miura T
    • Organizer
      第85回 日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] Treatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.2021

    • Author(s)
      Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy2021

    • Author(s)
      Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Mizuno M, Kuno A, Sugawara H, Fujita Y, Ino S, Ohwada W, Sato T, Yano T, Moniwa N, Tanno M, Miura T.
    • Organizer
      第85回 日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] SIRT1, a protein deacetylase, contributes to mitophagy by promotion of autophagosome-lysosome fusion in the cardiomyocyte.2020

    • Author(s)
      Atsushi Kuno
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] Distinct intracellular localization and possible functional significance of AMP deaminase in diabetic cardiomyopathy.2020

    • Author(s)
      Osanami A, Tanno M, Kuno A, Kouzu H, Yano T, Ogawa T, Kuno A, Sato T, Miura T.
    • Organizer
      第4回 日本循環器学会基礎研究フォーラム
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] 植物由来ポリフェノールであるピセアタンノールとレスベラトロールのSIRT1活性化を介した細胞保護作用の比較2020

    • Author(s)
      細田隆介 久野篤史 濱田博喜 堀尾嘉幸
    • Organizer
      第71回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Accumulation of free iron, but not protein-bound iron, in mitochondria may contribute to development of doxorubicin-induced cardiomyopathy.2020

    • Author(s)
      Sato T, Kikuchi T, Yano T, Miki T, Tanno M, Kuno A, Kouzu H, Miura T.
    • Organizer
      日本循環器学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08544
  • [Presentation] Xanthine oxidoreductase-mediated metabolic and functional dysfunction is amplified by upregulated AMP deaminase in diabetic hearts.2020

    • Author(s)
      Osanami A, Igaki Y, Tanno M, Sato T, Kouzu H, Kuno A, Miura T.
    • Organizer
      第 24 回 日本心不全学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] The histone deacetylase SIRT1 mediates the proper DNA repair response by targeting histone H2AX to protect against doxorubicin-induced cardiotoxicity.2020

    • Author(s)
      Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio
    • Organizer
      ESC Congress 2020
    • Data Source
      KAKENHI-PROJECT-20K07068
  • [Presentation] Deletion of SIRT1 in the skeletal muscle decreases type IIa oxidative muscle fiber in mice.2020

    • Author(s)
      Hosoda R, Kuno A, Asakura S, Horio Y.
    • Organizer
      Experimental Biology 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy.2020

    • Author(s)
      Ogawa T, Kouzu H, Tatekoshi Y, Osanami A, Oshima H, Mizuno M, Kuno A, Igaki Y, Sugawara H, Fujita Y, Sato T, Yano T, Tanno M, Miki T, Miura T.
    • Organizer
      ESC congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08452
  • [Presentation] マイトファジーにおける 蛋白脱アセチル化酵素SIRT1の役割2019

    • Author(s)
      久野 篤史
    • Organizer
      第70回 日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] Inhibitory phosphorylation of RIP1 at Ser320 induces nuclear translocation of TFEB, leading to suppression of necroptosis in cadiomyocytes.2019

    • Author(s)
      Abe K, Yano T, Sato T, Kouzu H, Kuno A, Tanno M, Miki T, Miura T.
    • Organizer
      ESC congress 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08544
  • [Presentation] 蛋白脱アセチル化酵素SIRT1はオーファゴソームの分解を介してマイトファジーを制御する2019

    • Author(s)
      久野 篤史
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] mTORC1 活性阻害はRIP1 の抑制的リン酸化により心筋細胞のネクロプトーシスを抑制する2019

    • Author(s)
      矢野俊之, 安部功記, 佐藤達也, 神津英至, 久野篤史, 丹野雅也, 三木隆幸, 三浦哲嗣
    • Organizer
      第40 回 日本循環制御医学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-19K08544
  • [Presentation] マイトファジー活性を標的とした筋ジストロフィーの新規治療法開発2019

    • Author(s)
      細田 隆介、久野篤史、堀尾嘉幸
    • Organizer
      第70回薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-19K07102
  • [Presentation] Impact of activation of necroptotic signaling on mitochondrial dynamics in cardiomyocytes.2019

    • Author(s)
      Yano T, Ong S, Sato T, Kouzu H, Kuno A, Tanno M, Miki T, Miura T.
    • Organizer
      CVMW2019 心血管代謝週間
    • Data Source
      KAKENHI-PROJECT-19K08544
  • [Presentation] Role of impaired autophagosome clearance in cardomyopathy of dystrophin-deficient mice.2018

    • Author(s)
      久野篤史、細田隆介、堀尾嘉幸
    • Organizer
      第82回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] SIRT1の活性化はマイトファジーにより障害ミトコンドリアを除去して筋ジストロフィー心筋障害を軽減する2018

    • Author(s)
      久野篤史
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy. 久野 篤史2018

    • Author(s)
      Atsushi Kuno
    • Organizer
      European Society of Cardiology Congress 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] レスベラトロールによる筋ジストロフィー治療2018

    • Author(s)
      久野篤史
    • Organizer
      第69回 日本薬理学会北部
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] Sirt1 Activation Restores Mitophagy-Mediated Clearance of Damaged Mitochondria and Ameliorates Dystrophic Cardiomyopathy in Mice2018

    • Author(s)
      Atsushi Kuno
    • Organizer
      American Heart Association Scientific Sessions 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] 筋ジストロフィー心筋におけるオートファジー不全の意義2017

    • Author(s)
      久野篤史、細田隆介、瀬堀理生、堀尾嘉幸
    • Organizer
      第68回日本薬理学会北部会
    • Data Source
      KAKENHI-PROJECT-17K08600
  • [Presentation] SIRT1はp300アセチラーゼを脱アセチル化・ユビキチン化して心肥大を抑制する2012

    • Author(s)
      久野篤史, ら
    • Organizer
      第85回日本薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-15
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] FOXOtranscription factors play a crucial role in the anti-cell death effects of SIRT1 under oxidative stress2012

    • Author(s)
      Hori YS, Kuno A, Hosoda R, Horio Y
    • Organizer
      Keystone Symposia "Aging and Diseases of Aging"
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] SIRT1 inhibits cardiomyocyte hypertrophy via negative regulation of p3002012

    • Author(s)
      Kuno A & Horio Y
    • Organizer
      Keystone Symposia "Aging and Diseases of Aging"
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] SIRT1活性化剤レスベラトロールはmdxマウスの筋線維化を抑制する2011

    • Author(s)
      堀佑輔、久野篤史、細田隆介、堀尾嘉幸
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      (横浜)
    • Year and Date
      2011-03-22
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Enhanced Proteasomal Degradation of p300 by its Deacetylation Underlies Inhibition of Hypertrophic Response by SIRT1 in Cardiomyocytes2011

    • Author(s)
      Kuno, et al
    • Organizer
      Scientific Sessions of American Heart Association 2011
    • Place of Presentation
      Orlando, USA
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Treatment with a SIRT1 activator resveratrol prevents cardiomyopathy in dystrophin-deficient mice2011

    • Author(s)
      久野篤史, ら
    • Organizer
      第15回日本心不全学会学術集会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Sirt1活性化剤レスベラトロールはdystrophin欠損による心筋障害を軽減する2011

    • Author(s)
      久野篤史、堀佑輔、細田隆介、三浦哲嗣、堀尾嘉幸
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      (横浜)
    • Year and Date
      2011-03-23
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] レスベラトロールとレスベラトロール配糖体の抗酸化作用と細胞死抑制機能の比較2011

    • Author(s)
      細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      (横浜)
    • Year and Date
      2011-03-22
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Resveratrol ameliorates muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011

    • Author(s)
      Hori YS, Hayashi T, Kuno A, Hosoda R, Horio Y
    • Organizer
      neuroscience Meeting
    • Place of Presentation
      Washington DC
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Resveratrol ameliorates dystrophic muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011

    • Author(s)
      Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
    • Organizer
      Gordon Research Conference Muscle Myogenesis:New Horizons for Myogenesis
    • Place of Presentation
      WaterVille Valley, USA
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Activation of SIRT1 suppresses cardiomyocyte hypertrophy by downregulating p300 via the ubiquitin-proteasome pathway2011

    • Author(s)
      久野篤史, ら
    • Organizer
      第34回分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice2011

    • Author(s)
      Kuno, et al
    • Organizer
      Scientific Sessions of American Heart Association 2011
    • Place of Presentation
      Orlando, USA
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] 蛋白脱アセチル化酵素Sirt1による心肥大抑制におけるp300発現制御の役割2010

    • Author(s)
      久野篤史、三浦哲嗣、島本和明、堀尾嘉幸
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] レスベラトロールとレスベラトロール配糖体の薬理作用の比較2010

    • Author(s)
      細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
    • Organizer
      第24回北海道薬物作用談話会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-24
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] レスベラトロール配糖体の酸化ストレス抑制作用2010

    • Author(s)
      細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Activation of Sirt1 suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via proteasome-mediated p300 degradation2010

    • Author(s)
      Kuno A, Tanno M, Ishikawa S, Miura T, Horio Y
    • Organizer
      AHA2010
    • Place of Presentation
      Chicago
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] レスベラトロール配糖体の酸化ストレス誘導性細胞死に対する抑制作用2010

    • Author(s)
      細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] SIRT1 inhibits oxidative stress-induced cell death by suppression of p53 and the ind MnSOD through FOXO transcription factor.2010

    • Author(s)
      Hori Y, Kuno A, Hosoda R, Horio Y
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] レスベラトロールによる筋ジストロフィーの治療2010

    • Author(s)
      堀佑輔、久野篤史、細田隆介、丹野雅也、堀尾嘉幸
    • Organizer
      薬物活性シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-11-12
    • Data Source
      KAKENHI-PROJECT-22590245
  • [Presentation] Sirt1 promotes p300 deacetylation and its degradation via the proteasome pathway.2010

    • Author(s)
      Kuno A, Miura T, Shimamoto K, Horio Y
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22590245
  • 1.  Yano Toshiyuki (40444913)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 33 results
  • 2.  HORIO Yoshiyuki (30181530)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 41 results
  • 3.  Hosoda Ryusuke (20749428)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 4.  Tanno Masaya (00398322)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 5.  藤谷 直樹 (10374191)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  野島 伊世里 (10827398)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 7.  Kouzu Hidemichi (60596609)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 8.  岩原 直敏 (00613085)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 9.  HAYASHI Takashi (90457698)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  KUNIMOTO Risa (20468094)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  山田 崇史 (50583176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  田中 希尚 (60533362)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  佐藤 達也 (40592473)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  MIURA Tetsuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 15.  久原 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  嵯峨 幸夏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  三木 隆幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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