Kuno Atsushi 久野篤史

… Alternative Names

Researcher Number	30468079
Other IDs
Affiliation (Current)	2021: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 札幌医科大学, 医学部, 准教授 2017: 札幌医科大学, 医学部, 講師 2012: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 47040:Pharmacology-related Except Principal Investigator Basic Section 53020:Cardiology-related / General pharmacology / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator オートファジー / SIRT1 / 心不全 / マイトファジー / オートファゴソーム / リソソーム / mTOR Except Principal Investigator SIRT1 / 心不全 / サーチュイン … More

心不全におけるオートファジー障害の機序解明と治療への応用Principal InvestigatorOngoing
- Principal Investigator
  
  久野篤史
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
アミノ酸ー核酸代謝連関の制御による心不全の新規治療開発Ongoing
- Principal Investigator
  
  神津英至
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
マイトファジーを標的とした筋ジストロフィ－の新規治療法開発Ongoing
- Principal Investigator
  
  細田隆介
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
ネクロプトーシスシグナル異常を標的とした心不全治療の開発Ongoing
- Principal Investigator
  
  矢野俊之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Novel role of SIRT1 in regulation of autophagy and its role in heart failurePrincipal Investigator
- Principal Investigator
  
  Kuno Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Functional roles of SIRT1 in the differentiation of neural cells
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University

All 2020 2019 2018 2017 2013 2012 2011 2010

All Journal Article Presentation Book Patent

[Book] 「レスベラトロールによる筋ジストロフィー治療の試み」レスベラトロールの基礎と応用(坪田一男監修)2012
- Author(s)
  久野篤史、堀尾嘉幸
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.2020
- Author(s)
  Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T.
- Journal Title
  
  Biochim Biophys Acta Mol Basis Dis
  
  Volume: 1865 Pages: 165552-165552
- DOI
  10.1016/j.bbadis.2019.165552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-19K08544
[Journal Article] Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats.2019
- Author(s)
  Oshima Hiroto、Miki Takayuki、Kuno Atsushi、Mizuno Masashi、Sato Tatsuya、Tanno Masaya、Yano Toshiyuki、Nakata Kei、Kimura Yukishige、Abe Koki、Ohwada Wataru、Miura Tetsuji
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 368 Pages: 524-534
- DOI
  10.1124/jpet.118.253666
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16016, KAKENHI-PROJECT-19K08544
[Journal Article] Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.2019
- Author(s)
  Kimura Yukishige、Kuno Atsushi、Tanno Masaya、Sato Tatsuya、Ohno Kouhei、Shibata Satoru、Nakata Kei、Sugawara Hirohito、Abe Koki、Igaki Yusuke、Yano Toshiyuki、Miki Takayuki、Miura Tetsuji
- Journal Title
  
  J Diabetes Investig.
  
  Volume: in Press Pages: 933-946
- DOI
  10.1111/jdi.13009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16016, KAKENHI-PROJECT-19K08544
[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019
- Author(s)
  Fujiwara D., Iwahara N., Sebori R., Hosoda R., Shimohama S., Kuno A., Horio Y.
- Journal Title
  
  PloS One
  
  Volume: 14
- DOI
  10.1371/journal.pone.0218329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
[Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018
- Author(s)
  Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 15555-15555
- DOI
  10.1038/s41598-018-33930-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] Resveratrol decreases oxidative stress by restoring mitophagy and improves the pathophysiology of dystrophin-deficient mdx mice.2018
- Author(s)
  Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y.
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2018 Pages: 13-13
- DOI
  10.1155/2018/9179270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.2013
- Author(s)
  Kuno A et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Pages: 5963-5972
- DOI
  10.1074/jbc.m112.392050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein2013
- Author(s)
  Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 5963-5972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress2013
- Author(s)
  Hosoda R, Kuno A, Hori YS, Ohtani K, Wakamiya N, Oohori A, Hamada H, Horio Y
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 344 Pages: 124-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] レスベラトロールの筋肉・神経疾患への応用2012
- Author(s)
  堀尾嘉幸、久野篤史
- Journal Title
  
  Anti-aging Medicine (アンチ・エイジング医学)
  
  Volume: Vol 8 Pages: 906-912
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Emerging beneficial roles of sirtuins in heart failure2012
- Author(s)
  Tanno M, Kuno A, Horio Y, Miura T
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 107 Pages: 273-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori SY , Kuno A, Hosoda R, Tanno M, MiuraT, Shimamoto K and Horio Y
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 338 Pages: 784-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Cellular and molecular effects of sirtuins in health and disease.2011
- Author(s)
  Horio Y, Hayashi T, Kuno A, Kunimoto R.
- Journal Title
  
  Clin.Sci.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Cellular and molecular effects of sirtuins in health and disease2011
- Author(s)
  Horio Y, Hayashi T, Kuno A, Kunimoto R
- Journal Title
  
  Clin Sci
  
  Volume: 121 Pages: 191-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells.2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2821-2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growthfactor-induced neurite outgrowth in PC12 cells2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 2821-2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] 筋ジストロフィーを処置するための組成物2011
- Inventor(s)
  堀尾嘉幸、堀佑輔、久野篤史
- Industrial Property Rights Holder
  堀尾嘉幸、堀佑輔、久野篤史
- Filing Date
  2011-09-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] 筋ジストロフィーを処置するための組2011
- Inventor(s)
  堀尾嘉幸、久野篤史、堀佑輔権
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] 筋ジストロフィーを処置するための組成物2010
- Inventor(s)
  堀尾嘉幸、堀佑輔、久野篤史
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2010-205453
- Filing Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1, a protein deacetylase, contributes to mitophagy by promotion of autophagosome-lysosome fusion in the cardiomyocyte.2020
- Author(s)
  Atsushi Kuno
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] Impact of activation of necroptotic signaling on mitochondrial dynamics in cardiomyocytes.2019
- Author(s)
  Yano T, Ong S, Sato T, Kouzu H, Kuno A, Tanno M, Miki T, Miura T.
- Organizer
  CVMW2019 心血管代謝週間
- Data Source
  KAKENHI-PROJECT-19K08544
[Presentation] マイトファジーにおける蛋白脱アセチル化酵素SIRT1の役割2019
- Author(s)
  久野　篤史
- Organizer
  第70回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] Inhibitory phosphorylation of RIP1 at Ser320 induces nuclear translocation of TFEB, leading to suppression of necroptosis in cadiomyocytes.2019
- Author(s)
  Abe K, Yano T, Sato T, Kouzu H, Kuno A, Tanno M, Miki T, Miura T.
- Organizer
  ESC congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08544
[Presentation] 蛋白脱アセチル化酵素SIRT1はオーファゴソームの分解を介してマイトファジーを制御する2019
- Author(s)
  久野　篤史
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] mTORC1 活性阻害はRIP1 の抑制的リン酸化により心筋細胞のネクロプトーシスを抑制する2019
- Author(s)
  矢野俊之, 安部功記, 佐藤達也, 神津英至, 久野篤史, 丹野雅也, 三木隆幸, 三浦哲嗣
- Organizer
  第40 回日本循環制御医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08544
[Presentation] マイトファジー活性を標的とした筋ジストロフィーの新規治療法開発2019
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第70回薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] The SIRT1 activator resveratrol ameliorates dystrophic cardiomyopathy by promoting mitophagy. 久野　篤史2018
- Author(s)
  Atsushi Kuno
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] Role of impaired autophagosome clearance in cardomyopathy of dystrophin-deficient mice.2018
- Author(s)
  久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] レスベラトロールによる筋ジストロフィー治療2018
- Author(s)
  久野篤史
- Organizer
  第69回日本薬理学会北部
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] Sirt1 Activation Restores Mitophagy-Mediated Clearance of Damaged Mitochondria and Ameliorates Dystrophic Cardiomyopathy in Mice2018
- Author(s)
  Atsushi Kuno
- Organizer
  American Heart Association Scientific Sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] SIRT1の活性化はマイトファジーにより障害ミトコンドリアを除去して筋ジストロフィー心筋障害を軽減する2018
- Author(s)
  久野篤史
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] 筋ジストロフィー心筋におけるオートファジー不全の意義2017
- Author(s)
  久野篤史、細田隆介、瀬堀理生、堀尾嘉幸
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] FOXOtranscription factors play a crucial role in the anti-cell death effects of SIRT1 under oxidative stress2012
- Author(s)
  Hori YS, Kuno A, Hosoda R, Horio Y
- Organizer
  Keystone Symposia "Aging and Diseases of Aging"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1 inhibits cardiomyocyte hypertrophy via negative regulation of p3002012
- Author(s)
  Kuno A & Horio Y
- Organizer
  Keystone Symposia "Aging and Diseases of Aging"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1はp300アセチラーゼを脱アセチル化・ユビキチン化して心肥大を抑制する2012
- Author(s)
  久野篤史, ら
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori YS, Hayashi T, Kuno A, Hosoda R, Horio Y
- Organizer
  neuroscience Meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates dystrophic muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
- Organizer
  Gordon Research Conference Muscle Myogenesis:New Horizons for Myogenesis
- Place of Presentation
  WaterVille Valley, USA
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1活性化剤レスベラトロールはmdxマウスの筋線維化を抑制する2011
- Author(s)
  堀佑輔、久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Activation of SIRT1 suppresses cardiomyocyte hypertrophy by downregulating p300 via the ubiquitin-proteasome pathway2011
- Author(s)
  久野篤史, ら
- Organizer
  第34回分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice2011
- Author(s)
  Kuno, et al
- Organizer
  Scientific Sessions of American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Enhanced Proteasomal Degradation of p300 by its Deacetylation Underlies Inhibition of Hypertrophic Response by SIRT1 in Cardiomyocytes2011
- Author(s)
  Kuno, et al
- Organizer
  Scientific Sessions of American Heart Association 2011
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロールとレスベラトロール配糖体の抗酸化作用と細胞死抑制機能の比較2011
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Treatment with a SIRT1 activator resveratrol prevents cardiomyopathy in dystrophin-deficient mice2011
- Author(s)
  久野篤史, ら
- Organizer
  第15回日本心不全学会学術集会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Sirt1活性化剤レスベラトロールはdystrophin欠損による心筋障害を軽減する2011
- Author(s)
  久野篤史、堀佑輔、細田隆介、三浦哲嗣、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロール配糖体の酸化ストレス誘導性細胞死に対する抑制作用2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロールによる筋ジストロフィーの治療2010
- Author(s)
  堀佑輔、久野篤史、細田隆介、丹野雅也、堀尾嘉幸
- Organizer
  薬物活性シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1 inhibits oxidative stress-induced cell death by suppression of p53 and the ind MnSOD through FOXO transcription factor.2010
- Author(s)
  Hori Y, Kuno A, Hosoda R, Horio Y
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] 蛋白脱アセチル化酵素Sirt1による心肥大抑制におけるp300発現制御の役割2010
- Author(s)
  久野篤史、三浦哲嗣、島本和明、堀尾嘉幸
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロールとレスベラトロール配糖体の薬理作用の比較2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第24回北海道薬物作用談話会
- Place of Presentation
  札幌
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロール配糖体の酸化ストレス抑制作用2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Activation of Sirt1 suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via proteasome-mediated p300 degradation2010
- Author(s)
  Kuno A, Tanno M, Ishikawa S, Miura T, Horio Y
- Organizer
  AHA2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Sirt1 promotes p300 deacetylation and its degradation via the proteasome pathway.2010
- Author(s)
  Kuno A, Miura T, Shimamoto K, Horio Y
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590245

1. HORIO Yoshiyuki (30181530)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
2. 矢野俊之 (40444913)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. HAYASHI Takashi (90457698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KUNIMOTO Risa (20468094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 藤谷直樹 (10374191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 野島伊世里 (10827398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 神津英至 (60596609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 細田隆介 (20749428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 岩原直敏 (00613085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 丹野雅也 (00398322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
11. MIURA Tetsuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 佐藤達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 三木隆幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuno Atsushi 久野 篤史

KUNO Atsushi 久野 篤史

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心不全におけるオートファジー障害の機序解明と治療への応用Principal InvestigatorOngoing

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アミノ酸ー核酸代謝連関の制御による心不全の新規治療開発Ongoing

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マイトファジーを標的とした筋ジストロフィ－の新規治療法開発Ongoing

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ネクロプトーシスシグナル異常を標的とした心不全治療の開発Ongoing

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Novel role of SIRT1 in regulation of autophagy and its role in heart failurePrincipal Investigator

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Functional roles of SIRT1 in the differentiation of neural cells

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[Book] 「レスベラトロールによる筋ジストロフィー治療の試み」レスベラトロールの基礎と応用(坪田一男監修)2012

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[Journal Article] mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.2020

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[Journal Article] Empagliflozin, an SGLT2 Inhibitor, Reduced the Mortality Rate after Acute Myocardial Infarction with Modification of Cardiac Metabolomes and Antioxidants in Diabetic Rats.2019

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[Journal Article] Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.2019

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[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019

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[Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018

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[Journal Article] Resveratrol decreases oxidative stress by restoring mitophagy and improves the pathophysiology of dystrophin-deficient mdx mice.2018

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[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.2013

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Kuno Atsushi 久野篤史

KUNO Atsushi 久野篤史

[Presentation] マイトファジーにおける蛋白脱アセチル化酵素SIRT1の役割2019