Hayakawa Masaki 早川正樹

… Alternative Names

Masaki Hayakawa 早川正樹

HAYAKAWA Masaki 早川正樹

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Researcher Number	30516729
Other IDs
Affiliation (Current)	2026: 奈良県立医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 奈良県立医科大学, 医学部, 研究員 2017 – 2022: 奈良県立医科大学, 医学部, 助教 2015: 奈良県立医科大学, 輸血部, 助教 2014 – 2015: 奈良県立医科大学, 医学部, 助教 2014: 奈良県立医科大学, 助教 2014: 奈良県立医科大学, 輸血部, 医員 2011 – 2013: 奈良県立医科大学, 医学部附属病院, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Hematology / Basic Section 90110:Biomedical engineering-related / Basic Section 54010:Hematology and medical oncology-related / Emergency medicine
Keywords	Principal Investigator フォンヴィレブランド因子 / ADAMTS13 / von willebrand factor / VWF / 後天性フォンヴィレブランド症候群 / 肺血栓塞栓症 / 抗A/B赤血球高抗体 / 抗A/B赤血球高抗原 / 抗VWF抗体 / 肺血栓塞栓症(PTE) … More / フォンヴィレブランド因子(VWF) / 後天性フォンヴィレブランド症候群(AVWS) / 心臓弁膜症 / 補助人工心臓 / 人工心肺 / AVWS / 循環器・高血圧 / Heyde症候群 / aVWS / 後天性フォンビレブランド症候群 / フォンビレブランド因子 / 血液型 / 大動脈弁狭窄症 … More Except Principal Investigator ADAMTS13 / VWF / TMA / 血行力学的環境応答 / 補助循環 / 血液剪断負荷 / 非臨床評価 / 後天性von Willebrand症候群 / 動物疾患モデル / 動物モデル / 血栓性血小板減少性紫斑病 / 流体解析 / 人工心臓 / 模擬循環回路 / 血液ポンプ / せん断 / 血栓 / 補助人工心臓 / 機械循環 / 出血 / 遠心ポンプ / LVAD / PCPS / ECMO / 出血合併症 / 血栓性微小血管障害症 / 細胞外ヒストン / トロンボモジュリン / von Willebrand因子 / 血管内皮細胞 / ヒストン / 血栓症 / 敗血症 / 血栓性微小血管症 / 造血幹細胞移植 / 胎盤E-NTPDase / 正常妊娠経過 / 妊娠中毒症 / 補体調節因子 / 活性型VWF / 胎盤由来E-NTPase / 胎盤由来E-NTPDase / VEF / HELLP症候群 / 妊娠関連TMA / SCT / 造血幹細胞移植学 Less

Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist
- Principal Investigator
  
  白石泰之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tohoku University
肺血栓塞栓症における血管閉塞を血液マーカーで診断する方法の開発Principal Investigator
- Principal Investigator
  
  早川正樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nara Medical University
Development of an animal model of acquired thrombotic thrombocytopenic purpura
- Principal Investigator
  
  Matsumoto Masanori
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nara Medical University
A novel strategy in diagnosis and therapy for acquired vonwillebrand syndrome associated with cardiovascular diseasePrincipal Investigator
- Principal Investigator
  
  MASAKI HAYAKAWA
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nara Medical University
Basic research for development of hemorrhagic complication therapeutic drug by long-term use of mechanical circulation
- Principal Investigator
  
  Inoue Yusuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Asahikawa Medical College
  Tohoku University
Clinical analysis in pathogensisis of gastrointestinal bleeding with severe aortic stenosis according to von willebrand facorPrincipal Investigator
- Principal Investigator
  
  Masaki Hayakawa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nara Medical University
Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Emergency medicine
- Research Institution
  Kagoshima University
Development of novel methods for diagnosis and management of thrombotic microangiopathy following stem cell transplantation
- Principal Investigator
  
  Matsumoto Masanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nara Medical University
Analysis of the pathology and regulation system in pregnancy-associated thrombotic microangiopathy (TMA)
- Principal Investigator
  
  FUJIMURA Yoshihiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nara Medical University
Development of novel therapy for thrombotic microangiopathy after hematopoietic stem cell transplantation.
- Principal Investigator
  
  MATSUMOTO Masanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Nara Medical University

All 2025 2024 2023 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Patent

[Journal Article] Mitral regurgitation is associated with similar loss of von Willebrand factor large multimers, but less anemia as compared to aortic stenosis2024
- Author(s)
  Takiguchi、Miura、Shirai、Soga、Hanyu、Sakaguchi、Soga、Arai、Watanabe、Kimura、Takahama、Yasuda、Nakayoshi、Fukumoto、Yaoita、Shimokawa、Sakatsume、Saiki、Kaikita、Tsujita、Tamura、Doman、Yamashita、Suzuki、Eura Yuka、Kokame Koichi、Hayakawa、Matsumoto、Okubo、Sugawara、Fujimaki、Kawate、Ando、Horiuchi
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 8 Issue: 4 Pages: 102431-102431
- DOI
  10.1016/j.rpth.2024.102431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27372, KAKENHI-PROJECT-23K25186, KAKENHI-PROJECT-23K07567, KAKENHI-PROJECT-23K07849
[Journal Article] von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis2024
- Author(s)
  Okubo N, Sugawara S, Fujiwara T, Sakatsume K, Doman T, Yamashita M, Goto K, Tateishi M, Suzuki M, Shirakawa R, Eura Y, Kokame K, Hayakawa M, Matsumoto M, Kawate Y, Miura M, Takiguchi H, Soga Y, Shirai S, Ando K, Arai Y, Nakayoshi T, Fukumoto Y, Takahama H, Yasuda S, Tamura T, Watanabe S, Kimura T, et al
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 8 Issue: 1 Pages: 102284-102284
- DOI
  10.1016/j.rpth.2023.102284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-23K07567, KAKENHI-PROJECT-23K25186, KAKENHI-PROJECT-23K27372, KAKENHI-PROJECT-22K08461, KAKENHI-PROJECT-23K07849
[Journal Article] Gastrointestinal Angiodysplasia before and after Treatment of Severe Aortic Stenosis2023
- Author(s)
  Yashige Masaki、Inoue Ken、Zen Kan、Kobayashi Reo、Nakamura Shunsuke、Fujimoto Tomotaka、Takamatsu Kazuaki、Sugino Satoshi、Yamano Michiyo、Yamano Tetsuhiro、Nakamura Takeshi、Doman Tsuyoshi、Teramukai Satoshi、Horiuchi Hisanori、Itoh Yoshito、Matoba Satoaki
- Journal Title
  
  New England Journal of Medicine
  
  Volume: 389 Issue: 16 Pages: 1530-1532
- DOI
  10.1056/nejmc2306027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07967, KAKENHI-PROJECT-23K25186
[Journal Article] No aggravation of congenital thrombotic thrombocytopenic purpura by mRNA-based vaccines against COVID-19: a Japanese registry survey2022
- Author(s)
  Hamada Eriko、Sakai Kazuya、Yamada Shinya、Kubo Masayuki、Hayakawa Masaki、Matsumoto Masanori
- Journal Title
  
  Annals of Hematology
  
  Volume: 101 Issue: 5 Pages: 1115-1117
- DOI
  10.1007/s00277-022-04774-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08461
[Journal Article] Optimization of anti-ADAMTS13 antibodies for the treatment of ADAMTS13-related bleeding disorder in patients receiving circulatory assist device support2021
- Author(s)
  Ito Toshihiro、Minamitani Takeharu、Hayakawa Masaki、Otsubo Ryota、Akiba Hiroki、Tsumoto Kouhei、Matsumoto Masanori、Yasui Teruhito
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 22341-22341
- DOI
  10.1038/s41598-021-01696-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16641, KAKENHI-PROJECT-20K08479, KAKENHI-PROJECT-20H02531, KAKENHI-PROJECT-20K16403
[Journal Article] Management of a COVID-19 Patient during ECMO: Paying Attention to Acquired von Willebrand Syndrome2021
- Author(s)
  Hayakawa Masaki、Takano Keisuke、Kayashima Michinori、Kasahara Kei、Fukushima Hidetada、Matsumoto Masanori
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 28 Issue: 4 Pages: 396-401
- DOI
  10.5551/jat.58362
- NAID
  130008014046
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2021-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08479
[Journal Article] Hemolysis and von Willebrand factor degradation in mechanical shuttle shear flow tester2021
- Author(s)
  Shiraishi Y, Tachizaki Y, Inoue Y, Hayakawa M, Yamada A, Kayashima M, Matsumoto M, Horiuchi H, Yambe T
- Journal Title
  
  J Artif Organs
  
  Volume: 24(2) Issue: 2 Pages: 111-119
- DOI
  10.1007/s10047-020-01219-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12748, KAKENHI-PROJECT-19K18021, KAKENHI-PROJECT-19K12772, KAKENHI-PROJECT-20K08479
[Journal Article] 微細管路系による流体剪断負荷とvon Willebrand factor損傷に関する特性評価の基礎検討2020
- Author(s)
  舘﨑祐馬，白石泰之，井上雄介，山田昭博，岩元直樹，盛田良介，Ahmad Faiz Ibadurrahman，橋本真登香，早川正樹，萱島道徳，松本雅則，堀内久徳，山家智之
- Journal Title
  
  人工臓器
  
  Volume: 49 Pages: 37-37
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08479
[Journal Article] 後天性フォンヴィレブランド症候群2020
- Author(s)
  早川正樹, 松本雅則
- Journal Title
  
  臨床血液
  
  Volume: 61/7 Pages: 809-817
- NAID
  130007884757
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08479
[Journal Article] 後天性フォンビレブランド症候群2020
- Author(s)
  早川正樹
- Journal Title
  
  臨床血液
  
  Volume: 61/7 Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09518
[Journal Article] Blood group antigen A on von Willebrand factor is more protective against ADAMTS13 cleavage than antigens B and H.2019
- Author(s)
  Hayakawa M, Kato S, Matsui T, Sakai K, Fujimura Y, Matsumoto M
- Journal Title
  
  Journal of thrombosis and haemostasis : JTH
  
  Volume: 17/ 6 Pages: 975-983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09518
[Journal Article] Blood group antigen A on von Willebrand factor is more protective against ADAMTS 13 cleavage than antigens B and H2019
- Author(s)
  Hayakawa Masaki、Kato Seiji、Matsui Taei、Sakai Kazuya、Fujimura Yoshihiro、Matsumoto Masanori
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: in press Issue: 6 Pages: 975-983
- DOI
  10.1111/jth.14444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09518
[Journal Article] A histological description of intestinal ‘angiodysplasia’ in an autopsy case of Heyde's syndrome2019
- Author(s)
  Tomoyuki Otani Kinta Hatakeyama Keigo Yamashita Yoshihiro Hayata Masaki Hayakawa Masanori Matsumoto Shigeki Taniguchi Chiho Ohbayashi
- Journal Title
  
  Pathology International
  
  Volume: 69/12 Issue: 12 Pages: 727-729
- DOI
  10.1111/pin.12874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09518
[Journal Article] von Willebrand Factor-Rich Platelet Thrombi in the Liver Cause Sinusoidal Obstruction Syndrome following Oxaliplatin-Based Chemotherapy.2015
- Author(s)
  Nishigori N, Matsumoto M, Koyama F, Hayakawa M, Hatakeyayama K, Ko S, Fujimura Y, Nakajima Y.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 11 Pages: e0143136-e0143136
- DOI
  10.1371/journal.pone.0143136
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461456
[Journal Article] STEC:O111-HUS complicated by acute encephalopathy in a young girl was successfully treated with a set of hemodiafiltration, steroid pulse, and soluble thrombomodulin, under plasma exchange.2015
- Author(s)
  Yada N, Fujioka M, Bennett CL, Inoki K, Miki T, Watanabe A, Yoshida T, Hayakawa M, Matsumoto M, Fujimura Y.
- Journal Title
  
  Clin Case Rep.
  
  Volume: 3 Issue: 4 Pages: 208-212
- DOI
  10.1002/ccr3.196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-25461456
[Journal Article] ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant :Implications for selection of plasma preparations for TTP treatment2013
- Author(s)
  Hori Y, Hayakawa M, Isonishi A, Soejima K, Matsumoto M, Fujimura Y
- Journal Title
  
  Transfusion
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment.2013
- Author(s)
  Hori Y, Hayakawa M, Isonishi A, Soejima K, Matsumoto M, Fujimura Y.
- Journal Title
  
  Transfusion.
  
  Volume: 53 Issue: 12 Pages: 3192-3202
- DOI
  10.1111/trf.12182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-25461456
[Journal Article] ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: Implications for selection of plasma preparations for TTP　treatment2013
- Author(s)
  Hori Y, Hayakawa M, Isonishi A, Soejima K, Matsumoto M, Fujimura Y
- Journal Title
  
  Transfusion
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591425
[Journal Article] Cilostazol down-regulates the height of mural platelet thrombi formed under a high-shear rate flow in the absence of ADAMTS13 activity2012
- Author(s)
  Yagi H, Yamaguchi N, Shida Y, Hayakawa M, Matsumoto M, Sugimoto M, Wada H, Tsubaki K, Fujimura Y
- Journal Title
  
  Eur J Pharm
  
  Volume: 691 Pages: 151-155
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] Two newborn-onset patients of Upshaw-Schulman syndrome with distinct subsequent clinical courses2012
- Author(s)
  Tanabe S, Yagi H, Kimura T, Isonishi A, Kato S, Yoshida Y, Hayakawa M, Matsumoto M, Ohtaki S, Takahashi Y, Fujimura Y
- Journal Title
  
  Int J Hematol
  
  Volume: 96 Pages: 789-797
- NAID
  10031144620
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] Cilostazol down-regulates the height of mural platelet thrombi formed under a high-shear rate flow in the absence of ADAMTS13 activity.2012
- Author(s)
  Yagi H, Yamaguchi N, Shida Y, Hayakawa M, Matsumoto M, Sugimoto M, Wada H, Tsubaki K, Fujimura Y.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 691 Issue: 1-3 Pages: 151-155
- DOI
  10.1016/j.ejphar.2012.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23591425
[Journal Article] Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombo- cytopenic purpura in a population from Japan2012
- Author(s)
  Matsumoto M, Bennett CL, Isonishi A, Qureshi Z, Hori Y, Hayakawa M, Yoshida Y, Yagi H, Fujimura Y
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] Two newborn-onset patients of Upshaw-Schulman syndrome with distinct subsequent clinical courses2012
- Author(s)
  Tanabe S, Yagi H, Kimura T, Isonishi A, Kato S, Yoshida Y, Hayakawa M, Matsumoto M, Ohtaki S, Takahashi Y, Fujimura Y.
- Journal Title
  
  Int J Hematol.
  
  Volume: 96 Issue: 6 Pages: 789-797
- DOI
  10.1007/s12185-012-1221-8
- NAID
  10031144620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591425
[Journal Article] 血栓性血小板減少性紫斑病(TTP)2012
- Author(s)
  石西綾美、早川正樹、松本雅則、八木秀男、藤村吉博
- Journal Title
  
  日本アフェレシス学会雑誌
  
  Volume: 31 Pages: 7-13
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] A typical HUS2012
- Author(s)
  吉田瑶子、松本雅則、早川正樹、藤村吉博
- Journal Title
  
  日本アフェレシス学会雑誌
  
  Volume: 31 Pages: 27-32
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombocyt openic purpura in a population from Japan2012
- Author(s)
  Matsumoto M, Bennett CL, Isonishi A, Qureshi Z, Hori Y, Hayakawa M, Yoshida Y, Yagi H, Fujimura Y
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 3 Pages: e33029-e33029
- DOI
  10.1371/journal.pone.0033029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23591425
[Journal Article] A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura.2012
- Author(s)
  Kawasaki Y, Toyoda H, Otsuki S, Iwasa T, Iwamoto S, Azuma E, Itoh-Habe N, Wada H, Fujimura Y, Morio T, Imai K, Mitsuiki N, Ohara O, Komada Y.
- Journal Title
  
  Eur J Haematol.
  
  Volume: 90 Issue: 2 Pages: 164-168
- DOI
  10.1111/ejh.12057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23390270, KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-23591561
[Journal Article] 血栓性微小血管障害性(TMA)の診断と治療戦略2011
- Author(s)
  藤村吉博、吉田瑶子、石西綾美、堀勇二、早川正樹、八木秀男、松本雅則
- Journal Title
  
  血液フロンティア
  
  Volume: 21 Pages: 43-59
- Data Source
  KAKENHI-PROJECT-22591069
[Journal Article] 血栓性微小血管障害症(TMA)と妊娠 -その診断と治療-2011
- Author(s)
  藤村吉博、八木秀男、石西綾美、山口直子、早川正樹、松本雅則、佐道俊幸
- Journal Title
  
  日本産婦人科・新生児血液学雑誌
  
  Volume: 20 Pages: 83-92
- NAID
  10029377850
- Data Source
  KAKENHI-PROJECT-22591069
[Patent] 血液、血球又は凝固関連因子に定量的にずり応力を加える剪断発生装置2023
- Inventor(s)
  山家智之、白石泰之、堀内久徳、松本雅則、早川正樹
- Industrial Property Rights Holder
  山家智之、白石泰之、堀内久徳、松本雅則、早川正樹
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Acquisition Date
  2023
- Data Source
  KAKENHI-PROJECT-23K25186
[Patent] 抗DAMTS13抗体及びその応用2020
- Inventor(s)
  松本雅則、早川正樹
- Industrial Property Rights Holder
  松本雅則、早川正樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-035392
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K08479
[Patent] 血液、血球又は凝固関連因子へ定量的にずり応力を加える剪断発生装置2019
- Inventor(s)
  早川正樹　松本雅則　白石泰之　山家智之
- Industrial Property Rights Holder
  早川正樹　松本雅則　白石泰之　山家智之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-192927
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K09518
[Patent] 血液、血球又は凝固関連因子へ定量的にずり応力を加える剪断発生装置2018
- Inventor(s)
  早川正樹、松本雅則ら
- Industrial Property Rights Holder
  早川正樹、松本雅則ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-192927
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K09518
[Presentation] 肺血栓塞栓症は出血性疾患？　-肺血栓塞栓症とフォンヴィレブランド止血因子破綻の切っても切れない関係-2025
- Author(s)
  早川正樹
- Organizer
  第64回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-23K07582
[Presentation] 肺血栓塞栓症に続発する止血異常症　-肺血栓塞栓症と後天性フォンヴィレブランド症候群-2025
- Author(s)
  早川正樹
- Organizer
  第32回肺塞栓症研究会学術集会
- Data Source
  KAKENHI-PROJECT-23K07582
[Presentation] フォンヴィレブランド因子に対する自己抗体検出・定量ELISAの検討2023
- Author(s)
  早川正樹
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07582
[Presentation] 補助循環時の後天性フォン・ヴィレブランド症候群を引き起こす流体剪断応答の評価システム制御系開発2023
- Author(s)
  深井実春, 白石泰之, Chikweto Francis, 深谷碧, Narracott Andrew, 早川正樹, 松本雅則, 堀内久徳, 山家智之
- Organizer
  日本人工臓器学会大会61回
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] 自己抗体型の抗フォンヴィレブランド因子抗体の定量ELISAの開発2023
- Author(s)
  早川正樹
- Organizer
  第24回日本検査血液学会学術集会
- Data Source
  KAKENHI-PROJECT-23K07582
[Presentation] Von Willebrand Factorの応答を考慮したECMOシステムの臨床的評価方法に関する検討2022
- Author(s)
  中野康太郎, 白石泰之, 山田昭博, 深谷碧, 菅野博童, 松浦健, 早川正樹, 松本雅則, 堀内久徳, 山家智之
- Organizer
  第60回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-23K25186
[Presentation] 後天性フォンヴィレブランド症候群（AVWS）とその治療に関する基礎・臨床研究について2022
- Author(s)
  早川正樹
- Organizer
  人工心臓と補助循環懇話会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 後天性フォンヴィレブランド症候群（AVWS）とその治療に関する基礎・臨床研究について2022
- Author(s)
  早川正樹
- Organizer
  人工心臓と補助循環懇話会学術集会（招待講演）
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 新型コロナウイルスワクチンによる血栓性血小板減少性紫斑病患者への影響2022
- Author(s)
  濱田恵理子, 山田真也, 酒井和哉, 久保政之, 早川正樹, 松本雅則
- Organizer
  第44回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08461
[Presentation] Differential Diagnosis Distinguishing Immune TTP from Septic DIC Using Plasma Levels of Haptoglobin and Factor XIII Activity.2022
- Author(s)
  Shinya Yamada, Masayuki Kubo, Eriko Hamada, Kenki Saito, Masaki Hayakawa, Hidesaku Asakura, Masanori Matsumoto.
- Organizer
  64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08461
[Presentation] 心臓血管外科手術における人工心肺離脱後のフォンヴィレブランド因子の動態変化2022
- Author(s)
  早川正樹
- Organizer
  血栓止血学会
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 心臓血管外科手術における人工心肺による体外循環中のフォンヴィレブランド因子の動態2021
- Author(s)
  早川正樹
- Organizer
  人工臓器学会
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 肺血栓塞栓症と後天性フォンヴィレブランド症候群の関係2020
- Author(s)
  早川正樹
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 新型コロナウイルス感染症に対する体外式膜型人工肺治療中に後天性フォンヴィレブランド症候群を呈した一例2020
- Author(s)
  早川正樹
- Organizer
  日本人工臓器学会
- Data Source
  KAKENHI-PROJECT-20K08479
[Presentation] 機械循環の高せん断によるフォンウィルブランド因子マルチマー切断に関する研究2020
- Author(s)
  井上雄介，早川正樹，山田昭博，佐原玄太，白石泰之，佐藤康史，武輪能明，堀内久徳，松本雅則，山家智之
- Organizer
  第58回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-19K12772
[Presentation] VWF切断生成物の定量的検査方法の開発と臨床応用2019
- Author(s)
  早川正樹
- Organizer
  第20回日本検査血液学会
- Data Source
  KAKENHI-PROJECT-17K09518
[Presentation] 後天性フォンビレブランド症候群について2019
- Author(s)
  早川正樹
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09518
[Presentation] 機械的流体剪断負荷とVWF損傷に関する実験的検討2019
- Author(s)
  舘崎祐馬、白石泰之、井上雄介、山田昭博、岩元直樹、盛田良介、Ahmad Faiz Ibadurrahman、橋本真登香、早川正樹、萱島道徳、松本雅則、堀内久徳、山家智之
- Organizer
  第6回加齢医学研究所リトリート
- Data Source
  KAKENHI-PROJECT-19K12772
[Presentation] 後天性von Willebrand病の血行力学的評価を目的とした流体剪断負荷試験装置の開発2019
- Author(s)
  舘崎祐馬、福澤奎人、白石泰之、井上雄介、山田昭博、早川正樹、萱島道徳、松本雅則、堀内久徳、山家智之
- Organizer
  第32回バイオエンジニアリング講演会
- Data Source
  KAKENHI-PROJECT-19K12772
[Presentation] ABO血液型A型抗原を持つvon Willebrand因子はADAMTS13による切断を受けにく2018
- Author(s)
  早川正樹
- Organizer
  第66回日本輸血・細胞治療学会総会
- Data Source
  KAKENHI-PROJECT-17K09518
[Presentation] Decreased platelet thrombus size, due to a heightened proteolysis of VWF by ADAMTS13 is quickly restored after valve replacement in aortic stenosis patients.2014
- Author(s)
  Yagi H, Hayakawa M, Yamaguchi N, Yamashita K, Taniguchi S, Matsumoto M, Tsubaki K, Fujimura Y
- Organizer
  The 56th Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-23591425
[Presentation] Introduction of a quick assay for ADAMTS13 activity improved a survival of acquired TTP patients who received platelet transfusions.2014
- Author(s)
  Yoshii　Ｙ, Matsumoto M, Kurumatani N, Isonishi A, Uemura M, Hori Y, Hayakawa M, Yagi H, Bennett C.L., Fujimura Y
- Organizer
  The 56th Annual meeting of American Society of Hematology
- Place of Presentation
  San Francisco（USA）
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-23591425
[Presentation] Size of vWF multimers, modulated by therapeutic regimens in hematopoietic stem cell transprantation, determine an adverse reaction to bleeding or thrombotic microangiopathy2011
- Author(s)
  M.Matsumoto, K.Yamada, K. Nakayama, A.Isonishi, M. Hayakawa, M.Inoue, K.Kawa, Y. Fujimura
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-27
- Data Source
  KAKENHI-PROJECT-22591069
[Presentation] A large-pore gel electrophoresis separates the complex in both of ADAMTS13 bound to VWF and to the IgG autoantibodies from the unbound in plasma milieu2011
- Author(s)
  M.Matsumoto, A.Isonishi, Y.Hori, M.Hayakawa, K. Soejima, Y. Fujimura
- Organizer
  The 54th American Society of Hematology annual meeting and exposition
- Place of Presentation
  San Diego
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22591069
[Presentation] Acquired idiopathic thrombotic thrombocytopenic purpura in a population from Japan2011
- Author(s)
  M.Matsumoto, C.Bennett, A. Isonishi, Z. Qureshi, Y.Hori, M. Hayakawa, Y.Yoshida, H.Yagi, Y. Fujimura
- Organizer
  The 73rd Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Nagoya
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22591069
[Presentation] 均一な集団と考えられるADAMTS13 活性著減（＜0.5%）後天性特発性TTP 150 例の解析.
- Author(s)
  松本雅則，Bennett Charles，石西綾美，Qureshi Zenia，堀勇二，早川正樹，吉田瑶子，八木秀男，藤村吉博.
- Organizer
  第34回日本血栓止血学会学術集会.
- Place of Presentation
  ハイアットリージェンシー（東京）
- Data Source
  KAKENHI-PROJECT-23591425
[Presentation] Unusually large VWF multimers appearing in patient plasmas of HSCT predispose TMA:Management with plasma ADAMTS13 and recombinant soluble thrombomodulin
- Author(s)
  Hayakawa M, Matsumoto M, Fujimura Y
- Organizer
  Jahrestagung der Gesellschaft fur Thrombose- und Hamostaseforschung (GTH)
- Place of Presentation
  ICM-Internationales Congress Center Munchen（ドイツ）
- Data Source
  KAKENHI-PROJECT-23591425
[Presentation] 均一な集団と考えられるADAMTS13 活性著減（＜0.5%）後天性特発性TTP 150 例の解析.
- Author(s)
  松本雅則，Bennett Charles，石西綾美，Qureshi Zenia，堀勇二，早川正樹，吉田瑶子，八木秀男，藤村吉博.
- Organizer
  第34回日本血栓止血学会学術集会.
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22591069
[Presentation] A long-term phenotype analysis of 51 patients with Upshaw -Schulman Syndrome in Japan, with special references to pregnancy and renal failure that requires hemodialysis
- Author(s)
  Fujimura Y, Yoshii Y, Matsumoto M, Isonishi A, Hayakawa M, Yoshida Y, Yagi H, Kokame K, Miyata T.
- Organizer
  The 55th Annual meeting of American Society of Hematology
- Place of Presentation
  Ernest N. Morial Convention Center（New Orleans, USA)
- Data Source
  KAKENHI-PROJECT-23591425

1. MATSUMOTO Masanori (60316081)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
2. FUJIMURA Yoshihiro (80118033)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
3. Inoue Yusuke (80611079)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 深谷碧 (20826060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 山田昭博 (40781448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. SADO Toshiyuki (50275335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITO Takashi (20381171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAHARA Mayumi (90707514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAHARA Ko-ichi (10381170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 酒井和哉 (60790384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 久保政之 (40646080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 山田真也 (50927803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 齋藤健貴 (30972400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 白石泰之 (00329137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 山家智之 (70241578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 白川龍太郎 (50581039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 堀内久徳 (90291426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. NAGASATO Tomoka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMADA Shingo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. EURA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. OHARA Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. IMAI Kohsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 大坪亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 小亀浩市

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 藤原亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 全完

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 井上健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayakawa Masaki 早川 正樹

Masaki Hayakawa 早川 正樹

HAYAKAWA Masaki 早川 正樹

Research Projects

Research Products

Co-Researchers

Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist

Principal Investigator

Project Period (FY)

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肺血栓塞栓症における血管閉塞を血液マーカーで診断する方法の開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

Development of an animal model of acquired thrombotic thrombocytopenic purpura

Principal Investigator

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Review Section

Research Institution

A novel strategy in diagnosis and therapy for acquired vonwillebrand syndrome associated with cardiovascular diseasePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Basic research for development of hemorrhagic complication therapeutic drug by long-term use of mechanical circulation

Principal Investigator

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Review Section

Research Institution

Clinical analysis in pathogensisis of gastrointestinal bleeding with severe aortic stenosis according to von willebrand facorPrincipal Investigator

Principal Investigator

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Research Institution

Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

Principal Investigator

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Development of novel methods for diagnosis and management of thrombotic microangiopathy following stem cell transplantation

Principal Investigator

Project Period (FY)

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Research Institution

Analysis of the pathology and regulation system in pregnancy-associated thrombotic microangiopathy (TMA)

Principal Investigator

Project Period (FY)

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Research Institution

Development of novel therapy for thrombotic microangiopathy after hematopoietic stem cell transplantation.

Principal Investigator

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Research Institution

[Journal Article] Mitral regurgitation is associated with similar loss of von Willebrand factor large multimers, but less anemia as compared to aortic stenosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gastrointestinal Angiodysplasia before and after Treatment of Severe Aortic Stenosis2023

Author(s)

Journal Title

DOI

Hayakawa Masaki 早川正樹

Masaki Hayakawa 早川正樹

HAYAKAWA Masaki 早川正樹