Sivasundaram Karnan シバスンダランカルナン

… Alternative Names

Researcher Number	30557096
Other IDs
Affiliation (Current)	2021: 愛知医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2014 – 2019: 愛知医科大学, 医学部, 講師 2010 – 2013: 愛知医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Tumor biology / Pathological medical chemistry / Basic Section 55040:Respiratory surgery-related Except Principal Investigator Carcinogenesis / Gastroenterology / Surgical dentistry / System genome science / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator ゲノム編集 / がん制御遺伝子 / ヒト細胞遺伝子改変法 / BRCA1 / ヒト細胞遺伝子改変 / KRAS / 変異ノックイン / 気管支上皮細胞株 / 気管支上皮 / 遺伝子改変 … More Except Principal Investigator ゲノム編集 / BRCA1 / ハプロ不全 / ゲノム不安定性 / ヒト細胞遺伝子改変 / ヒト細胞遺伝子改変法 / NASH / 肝発癌 / オリゴCGHアレイ / コリン欠乏食 / オリゴＣＧＨアレイ / ameloblastoma / TLR / reactive oxygen species / エナメル上皮腫 / 実験腫瘍学 / ゲノム / マイクロアレイ / 腫瘍 / ノックイン / CRISPR-Cas9 / nickase / ゲノム生物工学 / ヒト急性白血病 / FLT3 / CD52 / alemtuzumab / 白血病 / 遺伝子変異 Less

ゲノム編集によるFLT3変異改変ヒト白血病細胞の作製と新規治療法の探索Ongoing
- Principal Investigator
  
  花村一朗
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Aichi Medical University
ゲノム医療を目指した遺伝子異常に基づく悪性中皮腫発症機構の解明と治療標的の探索Principal InvestigatorOngoing
- Principal Investigator
  
  シバスンダランカルナン
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Medical University
CRISPR-Cas9 nickaseによるDNA二重鎖切断を伴わないゲノム編集Ongoing
- Principal Investigator
  
  小西裕之
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Aichi Medical University
Genomic diagnosis of ameloblastoma by high-resolution array comparative genomic hybridization and development of molecular target drug
- Principal Investigator
  
  KAZAOKA YOSHIAKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Aichi Medical University
Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell linePrincipal Investigator
- Principal Investigator
  
  Sivasundaram Karnan
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Aichi Medical University
Cyclopedic investigation of genes for NASH-mediated carcinogenesis
- Principal Investigator
  
  YONEDA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting
- Principal Investigator
  
  KONISHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Aichi Medical University
Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cellsPrincipal Investigator
- Principal Investigator
  
  SIVASUNDARAM Karnan
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Medical University

All 2020 2019 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532020
- Author(s)
  Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H
- Journal Title
  
  Cell Reports
  
  Volume: 30 Pages: 1195-1207
- DOI
  10.1016/j.celrep.2019.12.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K14703, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-19J40240, KAKENHI-PROJECT-16H06279
[Journal Article] Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020
- Author(s)
  Kanasugi J, Hanamura I, Ota A, Karnan S, Vu LQ, Mizuno S, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y, Takami A
- Journal Title
  
  Cancer Science
  
  Volume: - Pages: 999-999
- DOI
  10.1111/cas.14386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K14703
[Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020
- Author(s)
  Kondo S, Ota A, Ono T, Karnan S, Wahiduzzaman M, Hyodo T, Lutfur Rahman M, Ito K, Furuhashi A, Hayashi T, Konishi H, Tsuzuki S, Hosokawa Y, Kazaoka Y
- Journal Title
  
  Cancer Medicine
  
  Volume: 9(8) Pages: 2904-2917
- DOI
  10.1002/cam4.2931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08342, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K14703
[Presentation] P16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019
- Author(s)
  7.シバスンダランカルナン、太田明伸、花村一朗、村上秀樹、兵頭寿典、小西裕之、都築忍、細川好孝
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09292
[Presentation] CRISPRCas9を用いたNF2及びCDKN2Aノックアウト人中皮腫細胞株の樹立と分子生物学的解析2019
- Author(s)
  6.Sivasundaram Karnan, Akinobu ota, Ichiro Hanamura, Hideki Murakami, Toshinori Hyodo, Wahiduzzanan Md, Hiroyuki Konishi , Shinobu Tsuzuki, Yoshitaka Hosokawa
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K09292
[Presentation] Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells.2017
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 亜ヒ酸とシスプラチンによる併用療法はBcr-Abl陽性白血病細胞に対して相乗的な増殖抑制効果を示す2017
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] Protein phosphatase 2Aの調節サブユニットPPP2R5Eは微小管架橋因子MTCL1の発現量を制御する.2017
- Author(s)
  兵頭寿典, 稲見恵理, 太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する.2017
- Author(s)
  太田明伸, 花村一朗, Sivasundaram Karnan, Md Wahiduzzaman, 兵頭寿典, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] SINGLE-NUCLEOTIDE POLYMORPHISM IN THE PBK GENE IS CLOSELY ASSOCIATED WITH MYELOMA CELL PROLIFERATION.2017
- Author(s)
  Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Md Wahiduzzaman, Shohei Mizuno, Kaori Uchino, Jo Kanasugi, Tomohiro Horio, Satsuki Murakami, Susumu Suzuki, Ryuzo Ueda, Shinobu Tsuzuki, Hiroyuki Konishi, Yoshitaka Hosokawa, Akiyoshi Takami.
- Organizer
  The 22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 悪性胸膜中皮腫の早期診断腫瘍マーカーの検討.2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] CRISPR/Cas9を用いたNF2ノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析2017
- Author(s)
  Sivasundaram Karnan, 太田明伸, 花村一朗, 村上秀樹, 兵頭寿典, Md Wahiduzzaman, 小西裕之, 都築忍, 細川好孝.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07263
[Presentation] 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in leukemic cell lines2016
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Hiroyuki Konishi, Yoshitaka Hosokawa
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NOX1はAKTシグナルを介して口腔扁平上非癌細胞の生存に寄与する2016
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析2016
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 悪性胸膜中皮腫の早期診断の腫瘍マーカーの検討2016
- Author(s)
  Sivasundaram Karnan, 太田明伸, Md Wahiduzzaman, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] CRISPR-Cas9システムによる変異ノックイン ― プロモータートラップ法の比較検討2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場（広島・広島）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] PIGA遺伝子を利用したヒト体細胞株の遺伝子ターゲッティング効率の測定2012
- Author(s)
  シバスンダラン・カルナン
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子ターゲッティング効率定量系の作成2011
- Author(s)
  Sivasundaram Karnan
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22500999
[Presentation] ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子ターゲッティング効率定量系の作成2011
- Author(s)
  シバスンダラン・カルナン
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22700888
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395

1. KONISHI Hiroyuki (20344335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. HOSOKAWA Yoshitaka (60229193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. 太田明伸 (30438048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. YONEDA Masashi (30261407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAO Haruhisa (60326139)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKADE Haruhisa (70431400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAZAOKA YOSHIAKI (30233696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山田陽一 (20345903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大野隆之 (20434623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 花村一朗 (70440740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鈴木進 (70518422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 村上秀樹 (90303619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. ITOH Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 兵頭寿典

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 豊田敦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 鈴木穣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sivasundaram Karnan シバスンダラン カルナン

SIVASUNDARAM Karnan シバスンダラン カルナン

SHIBASUN Daran Karunan シバス ダランカルナン

Research Projects

Research Products

Co-Researchers

ゲノム編集によるFLT3変異改変ヒト白血病細胞の作製と新規治療法の探索Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゲノム医療を目指した遺伝子異常に基づく悪性中皮腫発症機構の解明と治療標的の探索Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CRISPR-Cas9 nickaseによるDNA二重鎖切断を伴わないゲノム編集Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomic diagnosis of ameloblastoma by high-resolution array comparative genomic hybridization and development of molecular target drug

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell linePrincipal Investigator

Principal Investigator

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Cyclopedic investigation of genes for NASH-mediated carcinogenesis

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Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting

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Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cellsPrincipal Investigator

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[Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532020

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[Journal Article] Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells2020

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[Journal Article] Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma2020

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[Presentation] P16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定2019

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[Presentation] CRISPRCas9を用いたNF2及びCDKN2Aノックアウト人中皮腫細胞株の樹立と分子生物学的解析2019

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[Presentation] Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells.2017

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Sivasundaram Karnan シバスンダランカルナン

SIVASUNDARAM Karnan シバスンダランカルナン

SHIBASUN Daran Karunan シバスダランカルナン