YOSHITAKA Hosokawa 細川好孝

… Alternative Names

Researcher Number	60229193
Other IDs
External Links
Affiliation (Current)	2022: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2022: 愛知医科大学, 医学部, 教授 2019 – 2020: 愛知医科大学, 医学部, 教授 2006 – 2016: Aichi Medical University School of Medicine, Department of Biochemistry, Professor, 医学部, 教授 2004 – 2005: Aichi Cancer Center, Div.Molecular Medicine, Section Head, 遺伝子医療研究部, 室長 2001 – 2003: 愛知県がんセンター, 遺伝子医療研究部, 室長 … More
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Hematology / Basic Section 53030:Respiratory medicine-related / Cell biology Except Principal Investigator Experimental pathology / Carcinogenesis / Pathological medical chemistry / Medical genome science / 代謝生物化学 / General medical chemistry / Hematology
Keywords	Principal Investigator アポトーシス / 悪性リンパ腫 / マルトリンパ腫 / 染色体転座 / サイクリンD1 / プロテオミクス / Malignant lymphoma / Chromosome translocation / apoptosis / 免疫組織化学 … More Except Principal Investigator 遺伝子改変 / ゲノム編集 / MALT1 / API2 / 国際学術 / 海外派遣 / ウイルス発癌 / シグナル伝達 / 構造生物学 / ゲノム医学 / 癌治療 / 化学発癌 / 細胞接着 / 細胞周期 / BRCA1 / ハプロ不全 / ゲノム不安定性 / ヒト細胞遺伝子改変 / ヒト細胞遺伝子改変法 / KRAS / 変異ノックイン / 気管支上皮細胞株 / 気管支上皮 / 肺癌 / 気道上皮 / アデノ随伴ウイルスベクター / CRISPR-Cas9 / 2A / プロラクチンレセプター / ステロイドホルモン / cDNAクローニング / ニワトリプロラクチンレセプター / PROLACTIN RECEPTOR / STEROID HORMONES / cDNA CLONING / ラット / Nb2リンフォーマ細胞 / G1サイクリン / サイクリンD2 / サイクリンD3 / 遺伝子発現 / プロモーター / プロラクチン / プレーTリンフォーマ / Nb2 / 下細胞分化増殖 / プロククチン / Nb2細胞 / T抗原レセプターγ / サイクリンD2・D3 / シグナル伝達経路 / 遺伝子発現制御 / G1 / S移行 / T細胞分化 / T細胞抗原γ鎖 / Rat / Nb2 lymphoma cell / G1 cyclin / Cyclin D2 / Cyclin D3 / Gene expression / Promoter / Prolactin / 染色体転座 / MLL / び慢性リンパ腫 / 大細胞型B細胞性リンパ腫 / MALTリンパ腫 / 大細胞B細胞性リンパ腫 / びまん性リンパ腫 / B細胞分化 / アポトーシス / MALT lymphoma / API2-MALT1 / Chromosome translocation / lymphoma / Diffuse large B cell lymphoma / TCBA1 Less

癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Aichi Medical University
胸膜中皮腫の予後改善を目指した診断マーカーと阻害化合物の探索Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Aichi Medical University
Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line
- Principal Investigator
  
  Sivasundaram Karnan
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Aichi Medical University
Development of a highly specific genome editing technology for human cells using adeno-associated viral vector
- Principal Investigator
  
  Hiroyuki Konishi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical genome science
- Research Institution
  Aichi Medical University
Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting
- Principal Investigator
  
  KONISHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Aichi Medical University
Molecular mechanism of anti-apoptotic action in MALT lymphoma and clinical applicationPrincipal Investigator
- Principal Investigator
  
  YOSHITAKA Hosokawa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University
Molecular mechanism underlying anti-apoptotic action in MALT lymphoma and clinical applicationPrincipal Investigator
- Principal Investigator
  
  YOSHITAKA Hosokawa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University
Molecular analysis of anti-apoptotic action in MALT lymphoma and its clinical application for diagnosis and treatment.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Yoshitaka
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University School of Medicine
  Aichi Cancer Center Research Institute
Molecular analysis of malignant lymphoma-related oncogenes and its clinical application for diagnosis and treatment.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Yoshitaka
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center
BCL6がん遺伝子とAPI2-MALT1融合遺伝子の機能解析と診断治療への応用Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
Molecular analysis of B-cell malignant lymphoma-related oncogenes and its clinical application for diagnosis and treatment.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Yoshitaka
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center
BCL6がん遺伝子とAPI2-MALT1融合遺伝子の機能解析と診断治療への応用Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
リンパ腫瘍におけるサイクリンD1トランスクリプトbの役割と診断、治療への応用Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Aichi Cancer Center Research Institute
Chromosome translocation junction genes on lympho-hematopoietic cell proliferation and differentiation
- Principal Investigator
  
  SETO Masao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center
リンパ腫瘍におけるサイクリンD1トランスクリプトbの役割と診断、治療への応用Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Aichi Cancer Center Research Institute
Functional analysis of cyclin D1 alternative transcript bPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Yoshitaka
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  AICHI CANCER CENTER
アメリカ大陸を中心としたがん研究先進グループとの研究交流
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
高等動物G1/S期移行を制御する遺伝子群の単離と発現制御に関する研究Principal Investigator
- Principal Investigator
  
  細川好孝
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Mie University
Signal Transduction and Control of T-cell function by Prolactin
- Principal Investigator
  
  NAKASHIMA Kunio
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Mie University
Study on the function of chicken kidney prolactin receptor in regulation on electrolite metabolism
- Principal Investigator
  
  TANAKA Minoru
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  MIE UNIVERSITY

[Journal Article] Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma2020
- Author(s)
  KarnanS, Ota A, Murakami H, Rahman ML, Hasan 　MN, Wahiduzzaman MD, Hanamura I, Vu LQ, Inoko A, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 18 Pages: 114-114
- DOI
  10.1038/s41420-020-00364-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08668, KAKENHI-PROJECT-19K09292, KAKENHI-PROJECT-18K07031, KAKENHI-PROJECT-18K08342
[Journal Article] Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma.2019
- Author(s)
  Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Hosokawa Y.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 180-193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08668
[Journal Article] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.2017
- Author(s)
  Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Nakade Y, Sato K, Itoh K, Konishi H, Hosokawa Y, Yoneda M
- Journal Title
  
  Journal of Cell Science
  
  Volume: 130 Pages: 614-625
- DOI
  10.1242/jcs.190736
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-16K09381, KAKENHI-PROJECT-17K09442, KAKENHI-PROJECT-17K07263
[Journal Article] Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines.2016
- Author(s)
  Ito K, Ota A, Ono T, Nakaoka T, Wahiduzzaman M, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, and Kazaoka Y
- Journal Title
  
  Oncology Reports
  
  Volume: 36 Pages: 2991-2998
- DOI
  10.3892/or.2016.5068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561
[Journal Article] Efficient AAV-mediated gene targeting using 2A-based promoter-trap system2016
- Author(s)
  Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Tsuzuki S, Hosokawa Y, and Konishi H
- Journal Title
  
  Bio-Protoc
  
  Volume: 6
- DOI
  10.21769/bioprotoc.2058
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460395
[Journal Article] Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide.2016
- Author(s)
  Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, and Konishi H
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 44
- DOI
  10.1093/nar/gkv1338
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107, KAKENHI-PROJECT-15K19561
[Journal Article] Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species2015
- Author(s)
  Tanaka M, Miura Y, Numanami H, Karnan S, Ota A, Konishi H, Hosokawa Y, and Hanyuda M
- Journal Title
  
  Oncology Reports
  
  Volume: 34 Pages: 1726-1732
- DOI
  10.3892/or.2015.4155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells.2015
- Author(s)
  Mizuno, S., Hanamura, I., Ota, A., Karnan, S., Narita, T., Ri, M., Mizutani, M., Goto, M., Gotou, M., Tsunekawa, N., Shikami, M., Iida, S., Hosokawa, Y., Miwa, H., Ueda, R., Nitta, M. and Takami, A
- Journal Title
  
  Int J Hematol.
  
  Volume: 102 Pages: 569-578
- DOI
  10.1007/s12185-015-1859-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09513, KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561
[Journal Article] High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas2015
- Author(s)
  Asai A, Karnan S, Ota A, Takahashi M, Damdindorj L, Konishi Y, Hossain E, Konishi H, Nagata A, Yokoo K, Hosokawa Y
- Journal Title
  
  Gene
  
  Volume: 558 Pages: 220-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395
[Journal Article] Plumbagin suppresses tumor cell growth in oral squamous cell carcinoma cell lines2015
- Author(s)
  Ono T, Ota A, Ito K, Nakaoka T, Karnan S, Konishi H, Furuhashi A, Hayashi T, Yamada Y, Hosokawa Y, Kazaoka Y
- Journal Title
  
  Oral Dis
  
  Volume: -
- DOI
  10.1111/odi.12310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas2015
- Author(s)
  Asai A, Karnan S, Ota A, Takahashi M, Damdindorj L, Konishi Y, Hossain E, Konishi H, Nagata A, Yokoo K, Hosokawa Y
- Journal Title
  
  Gene
  
  Volume: 558 Pages: 220-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640107
[Journal Article] Lipopolysaccharide augments the uptake of oxidized LDL by up-regulating lectin-like oxidized LDL receptor-1 in macrophages2015
- Author(s)
  Hossain E, Ota A, Karnan S, Takahashi M, Mannan SB, Konishi H, Hosokawa Y
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 400 Pages: 29-40
- DOI
  10.1007/s11010-014-2259-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells.2014
- Author(s)
  Nakaoka T, Ota A, Ono T, Karnan S, Konishi H, Furuhashi A, Ohmura Y, Yamada Y, Hosokawa Y, and Kazaoka Y.
- Journal Title
  
  Cell Oncol
  
  Volume: 37 Pages: 119-129
- DOI
  10.1007/s13402-014-0167-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] A comparative analysis of constitutive promoters located in adeno-associated viral vectors2014
- Author(s)
  Damdindorj L, Karnan S, Ota A, Hossain E, Konishi Y, Hosokawa Y, Konishi H
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0106472
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.2013
- Author(s)
  Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir AM, Gustin JP, Rosen DM, Denmeade S, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran R, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, and Park BH.
- Journal Title
  
  Cancer Res
  
  Volume: 73 Pages: 3248-3261
- DOI
  10.1158/0008-5472.can-12-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Arsenic trioxide prevents nitric oxide production in LPS-stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway2013
- Author(s)
  Takahashi M, Ota A, Karnan S, Ekhtear H, Konishi Y, Damdindorj L, Konishi H, Yokochi T, Nitta M, Hosokawa Y.
- Journal Title
  
  Cancer Science
  
  Volume: 104 Pages: 165-70
- DOI
  10.1111/cas.12053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Takahashi M, Karnan S, Damdindorj L, Konishi Y, Konishi H, and Hosokawa Y.
- Journal Title
  
  Toxicol Lett
  
  Volume: 220 Pages: 70-75
- DOI
  10.1016/j.toxlet.2013.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Takahashi M, Konishi Y, Konishi H, and Hosokawa Y.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 273 Pages: 651-658
- DOI
  10.1016/j.taap.2013.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-25640107
[Journal Article] Assessment of the long-term transcriptional activity of a 550-bp-long human ss-actin promoter region.2012
- Author(s)
  Damdindorj L, Karnan S, Ota A, Takahashi M, Konishi Y, Hossain E, Hosokawa Y, Konishi H.
- Journal Title
  
  Plasmid
  
  Volume: 68 Pages: 195-200
- DOI
  10.1016/j.plasmid.2012.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] A system for the measurement of gene targeting efficiency in human cell lines using an antibiotic resistance-GFP fusion gene.2012
- Author(s)
  Konishi Y, Karnan S, Takahashi M, Ota A, Damdindorj L, Hosokawa Y, Konishi H.
- Journal Title
  
  BioTechniques
  
  Volume: 53 Pages: 141-152
- DOI
  10.2144/0000113911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.2012
- Author(s)
  Karnan S, Konishi Y, Ota A, Takahashi M, Damdindorj L, Hosokawa Y, Konishi H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- DOI
  10.1371/journal.pone.0047389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999
[Journal Article] Ben Ho Park. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells2011
- Author(s)
  Hiroyuki Konishi ; Morassa Mohseni ; Akina Tamaki ; Joseph P, Garay ; Sarah Croessmann ; Sivasundaram Karnan ; Akinobu Ota ; Hong Yuen Wong ; Yuko Konishi ; Berdy Karakas ; Khola Tahir ; Abde M. Abukhdeir ; JohnP. Gustin ; Justin Cidado ; Grace M. Wang ; David Cosgrove ; Rory Cochran ; Danijela Jelovac ; Michaela J. Higgins ; Sabrina Arena ; Laeren Hawkins ; Josh Lauring ; Amy L. Gross ; Christopher M. Heaphy ; Yoshitaka Hosokawa ; Edward Gabrielson ; Alan K. Meeker ; Kala Visvanathan ; Pedram Argani ; Kurtis E. Bachman
- Journal Title
  
  PNAS
  
  Volume: 10 Pages: 1073-1073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591225
[Journal Article] Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells2011
- Author(s)
  Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH.
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 108 Pages: 17773-17778
- DOI
  10.1073/pnas.1110969108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500999, KAKENHI-PROJECT-22700888
[Journal Article] Controversial BRACA1 allelotypes in commonly used breast cancer cell lines2010
- Author(s)
  Karnan S, Mohseni M, Konishi Y, Tamaki A, Hosokawa Y, H. Park B, Konishi H
- Journal Title
  
  Breast Cancer Res Treat
  
  Volume: 119 Pages: 249-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591225
[Journal Article] ミモシンのプロオキシダント作用2008
- Author(s)
  村上惠子, 羽根田みや子, 喬善楼(中部大・生命科学), 細川好孝, 吉野昌孝
- Journal Title
  
  遷移金属複合体による活性酸素種の生成微量栄養素研究 25
  
  Pages: 76-80
- Data Source
  KAKENHI-PROJECT-19591143
[Journal Article] ミモシンのプロオキシダント作用遷移金属複合体による活性酸素種の生成2008
- Author(s)
  村上恵子ら(細川好孝)
- Journal Title
  
  微量栄養素研究 25
  
  Pages: 76-80
- Data Source
  KAKENHI-PROJECT-19591143
[Journal Article] ピリジンカルボン酸遷移金属複合体による活性酸素の生成2007
- Author(s)
  村上恵子, 羽根田みや子, 細川好孝, 吉野昌孝
- Journal Title
  
  微量栄養素研究 24
  
  Pages: 409-55
- NAID
  40015808255
- Data Source
  KAKENHI-PROJECT-19591143
[Journal Article] Molecular pathogenesis of MALT lymphoma : two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein.2006
- Author(s)
  Nakagawa M, Seto M, Hosokawa Y.
- Journal Title
  
  Leukemia 20
  
  Pages: 929-936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2005
- Author(s)
  Hosokawa Y et al.
- Journal Title
  
  Apoptosis 10
  
  Pages: 25-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma. Review Article2005
- Author(s)
  Hosokawa Y.
- Journal Title
  
  Apoptosis 10
  
  Pages: 25-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2005
- Author(s)
  Hosokawa Y.
- Journal Title
  
  Review Article Apoptosis 10
  
  Pages: 25-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10.2005
- Author(s)
  Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, Asaka M, Seto M.
- Journal Title
  
  Blood 106
  
  Pages: 4210-4216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2005
- Author(s)
  Hosokawa et al.
- Journal Title
  
  Apotosis 10
  
  Pages: 25-34
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] MALTリンパ腫におけるNF-kBの活性化と抗アポトーシス作用2005
- Author(s)
  中川雅人, 細川好孝
- Journal Title
  
  血液・腫瘍科 51
  
  Pages: 433-440
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-κB binding elements ; evidence for a positive feed-back loop pathway resulting in unremitting NF-κB activation.2005
- Author(s)
  Hosokawa et al.
- Journal Title
  
  B.B.R.C. 334
  
  Pages: 51-60
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-кB binding elements; evidence for a positive feed-back loop pathway resulting in unremitting NF-кB activation.2005
- Author(s)
  Hosokawa Y, Suzuki H, Nakagawa M, Lee TH, Seto M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 334
  
  Pages: 51-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] API2-MALT1 fusion protein induces transcriptional activation of the API2 gene through NF-κB binding elements; evidence for a positive feed-back loop pathway resulting in unremitting NF-κB activation.2005
- Author(s)
  Hosokawa Y et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun 334
  
  Pages: 51-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] MALTリンパ腫におけるNF-kBの活性化と抗アポトーシス作用2005
- Author(s)
  中川雅夫, 細川好孝
- Journal Title
  
  血液腫瘍科 51
  
  Pages: 433-439
- Data Source
  KAKENHI-PROJECT-17591023
[Journal Article] Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2005
- Author(s)
  Hosokawa Y et al.
- Journal Title
  
  Apoptosis 10
  
  Pages: 25-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] MASL1,a candidate oncogene found in amplication at 8p23.1,is translocated in immunoblastic B-cell lymphoma cell line OCI-LY8.2004
- Author(s)
  Tagawa H., Karnan S, Kasugai Y, Tuzuki S, Suzuki R, Hosokawa Y, Seto M.
- Journal Title
  
  Oncogene 23
  
  Pages: 2576-2581
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Anti-apoptotic function of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2004
- Author(s)
  Hosokawa Y et al.
- Journal Title
  
  Cancer Research 64
  
  Pages: 3452-3457
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Anti-apoptotic function of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma.2004
- Author(s)
  Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M.
- Journal Title
  
  Cancer Research 64
  
  Pages: 3452-3457
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] NF-kB activation and anti-apoptosis in MALT lymphoma.2004
- Author(s)
  Hosokawa Y, Seto M.
- Journal Title
  
  Progress in Hematology Review Article Int.J.Heamatol. 80
  
  Pages: 215-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Comparison of genetic aberrations in CD10(+) diffused large B-cell lymphoma and follicular lymphoma by comparative genomic hybridization and tissue-fluorescence in situ hybridization.2004
- Author(s)
  Zhang X, Karnan S, Tagawa H, Suzuki R, Tsuzuki S, Hosokawa Y, Morishima Y, Nakamura S, Seto M.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 809-814
- NAID
  10014170490
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] NF-kB activation and anti-apoptosis in MALT lymphoma.2004
- Author(s)
  Hosokawa Y et al.
- Journal Title
  
  Int.J.Heamatol. 80
  
  Pages: 215-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Mutational analysis of the ST7 gene in human myeloid tumor cell lines.2003
- Author(s)
  Sivasundaram K, Suzuki H, Seto M, Hosokawa Y.
- Journal Title
  
  Oncology Reports 10
  
  Pages: 1737-1739
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Heterogeneous copy number of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma.2003
- Author(s)
  Suguro-Katayama M, Suzuki R, Kasugai Y, Nakamura T, Suzuki H, Hosokawa Y, Shiku H, Nakamura S, Seto M.
- Journal Title
  
  Leukemia 17
  
  Pages: 2508-2512
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Journal Article] Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18)(q21;q21) MALT lymphoma.2003
- Author(s)
  Izumiyama K, Nakagawa M, Yonezumi M, Kasugai K, Suzuki R, Suzuki H, Tsuzuki S, Hosokawa Y, Asaka M, Seto M.
- Journal Title
  
  Oncogene 22
  
  Pages: 8085-8092
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591034
[Presentation] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in leukemic cell lines2016
- Author(s)
  Md Wahiduzzaman, Akinobu Ota, Sivasundaram Karnan, Hiroyuki Konishi, Yoshitaka Hosokawa
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 悪性胸膜中皮腫の早期診断の腫瘍マーカーの検討2016
- Author(s)
  Sivasundaram Karnan, 太田明伸, Md Wahiduzzaman, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析2016
- Author(s)
  太田明伸, Md Wahiduzzaman, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城・仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NOX1はAKTシグナルを介して口腔扁平上非癌細胞の生存に寄与する2016
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] CRISPR-Cas9システムによる変異ノックイン ― プロモータートラップ法の比較検討2016
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 都築忍, 細川好孝
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場（広島・広島）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] 1.400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Delta40p53はHepG2細胞に対して細胞増殖抑制効果を示す2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 癌原性KRAS変異をノックインしたヒト気管支上皮細胞株モデルの樹立と解析2015
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析2015
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する2015
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 細川好孝
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] KRAS変異およびPIK3CA変異のノックインを施したヒト上皮細胞株の生化学的解析.2013
- Author(s)
  Sivasundaram Karnan, 太田明伸, 細川好孝, 小西裕之.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] Arsenic trioxide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Konishi Y, Konishi H, Hosokawa Y.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] Arsenic trioxide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells.2013
- Author(s)
  Hossain E, Ota A, Karnan S, Damdindorj L, Konishi Y, Konishi H, Hosokawa Y.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] ヒ素は酸化LDL受容体LOX-1の発現を増加させることによりマウス血管内皮細胞の酸化LDL取り込み能を増強する.2013
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Damdindorj Lkhagvasuren, 小西裕子, 小西裕之, 細川好孝.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] ヒト細胞株のゲノム編集によるKRAS-PI3Kシグナル経路の解析.2013
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] BRCA1ヘテロ変異によってヒト乳癌上皮細胞にゲノム不安定性が発生する2011
- Author(s)
  小西裕之; Sivasundaram Karnan ;細川好孝; Park Ben H
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ピリジン還化合物による活性酸素生成と阻害2011
- Author(s)
  村上恵子;細川好孝;吉野昌孝
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ヒドロキシケトン化合物による活性酸素生成2011
- Author(s)
  村上恵子, 細川好孝, 吉野昌孝
- Organizer
  日本微量栄養素学会第28回学術集会
- Place of Presentation
  京都
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] BRCA1ヘテロ変異はヒト乳腺上皮細胞のゲノム不安定性を誘導する2011
- Author(s)
  小西裕之; Sivasundaram Karnan ;細川好孝
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] CCL8濃度とCCL8陽性細胞の増加はマウス肺のGVHD病態と密接に関与する2011
- Author(s)
  太田明伸;山本雅樹;今井伸一;小西裕之;細川好孝;小海康夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子タ-ゲッティング効率定量系の作成2011
- Author(s)
  Sivasundaram Karnan ;小西裕子;高橋美裕希; Damdindorj Lkhagvasuren ;細川好孝;小西裕之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ポリアミンと一価カチオンによるグルタチオンレダクターゼの活性調節2010
- Author(s)
  村上恵子;細川好孝;吉野昌孝
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] Functional analyses of cancer genes using a new procedure of somatic cell gene targeting in human cell lines2010
- Author(s)
  Hiroyuki Konishi, Sivasundaram Karnan, Miyuki Takahashi, Damdindorj Lkhagvasuren, Yuko Konishi, Yoshitaka Hosokawa
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ヒト培養細胞遺伝子改変の新技術を用いた癌関連遺伝子の機能解析2010
- Author(s)
  小西裕之;シバスンダランカルナン;細川好孝
- Organizer
  第69回日本癌学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ポリアミンの細胞毒性2010
- Author(s)
  村上恵子;細川好孝;吉野昌孝
- Organizer
  日本微量栄養素学会
- Place of Presentation
  京都
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] A new protocol of somatic cell gene targeting in human cell lines and its application to breast cancer research2010
- Author(s)
  Hiroyuki Konishi and Yoshitaka Hosokawa
- Organizer
  The 15th Japan-Korea Cancer Research Workshop
- Place of Presentation
  仁川(大韓民国)
- Year and Date
  2010-12-21
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] 還元型銅イオンを介したパン酵母Glutathione reductaseの酸化失活と部位特異的切断2009
- Author(s)
  村上恵子;坪内凉子;深山実;喬善楼;細川好孝;吉野昌孝
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] 急性前骨髄球性白血病におけるゲノムワイドアレイCGH解析2009
- Author(s)
  Karnan Sivasundaram ;小西裕之;瀬戸加大;細川好孝
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ヒト培養細胞遺伝子改変の新しい技術とその医学研究における応用2009
- Author(s)
  小西裕之、細川好孝
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] 遺伝子改変ヒト細胞株単離の新技術とその癌研究における利用2009
- Author(s)
  小西裕之, 細川好孝
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ヒト培養細胞遺伝子改変の新しい技術とその医学研究における応用2009
- Author(s)
  小西裕之, 細川好孝
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] 遺伝子改変ヒト細胞株単離の新技術とその癌研究における利用2009
- Author(s)
  小西裕之;細川好孝
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] アロエ成分のアントラキノン化合物による活性酸素種の生成2009
- Author(s)
  村上恵子、坪内凉子、細川好孝、吉野昌孝
- Organizer
  日本微量栄養素学会第26回学術集会
- Place of Presentation
  京都
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21591225
[Presentation] ミモシン鉄複合体による活性酸素生成2008
- Author(s)
  村上恵子, 羽根田みや子, 細川好孝, 喬善楼(中部・生命科学),吉野昌孝(金城学院大)
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] マントル細胞性リンパ腫細胞株におけるレスベラトロールによるアポトーシスの誘導2008
- Author(s)
  羽根田みや子, 大橋寛史, 星野弘典, 三浦裕次, 坪内凉子, 細川好孝
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] 中皮腫細胞におけるレスベラトロールによるアポトーシス誘導2008
- Author(s)
  坪内凉子, 三浦裕次, 田中元也, 細川好孝
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] 中皮腫細胞におけるレスべラトロールによるアポトーシス誘導2008
- Author(s)
  坪内涼子ら(細川好孝)
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] マントル細胞性リンパ腫細胞株におけるレスべラトロールによるアポトーシスの誘導2008
- Author(s)
  羽根田みや子ら(細川好孝)
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] ミモシンのプロオキシダント作用 : 遷移金属複合体による活性酸素種の生成2008
- Author(s)
  村上惠子、羽根田みや子、喬善楼*、細川好孝、吉野昌孝
- Organizer
  第25回微量栄養素学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] 悪性中皮腫におけるNox4の抑制によるアポトーシス誘導2008
- Author(s)
  三浦裕次, 細川好孝
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] マントル細胞リンパ腫におけるストローマ依存性薬剤体制の克服2008
- Author(s)
  三浦裕次, 坪内凉子, 羽根田みや子, 竹内章夫, 吉野恵子, 西本行男, 細川好孝
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] マントル細胞リンパ腫におけるストローマ依存性薬剤耐性の克服2008
- Author(s)
  三浦裕次ら(細川好孝)
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] マルトリンパ腫の責任癌遺伝子AP12-MALT1はNF-κBの活性化を介してアポトーシス抑制因子AP12の転写を促進する2007
- Author(s)
  細川好孝, 西本行男, 吉野恵子, 坪内凉子, 三浦裕次
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] Rac1-dependent NADPH oxidase 1 activation in tumor colon epithelial cell2007
- Author(s)
  Yukio Nisimoto, Ryoko Tsubouchi, Yositaka Hosokawa, Becky Diebold (Dept of Pathol., Med. Sch. Emory Univ.), Shanlou Qiao (Dept. of Biomed. Sci., Chubu Univ. College of Life and Health Sci.), Hisamitsu Ogawa (Dept. of Biol., Fujita Health Univ., Sch. of Med.)
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] 慢性リンパ性白血病におけるCXCR4/SDF-1による遊走反応と細胞生存の制御機構2007
- Author(s)
  三浦裕次, Elinor Lee (NIH), Adrian Wiesther(NIH), 細川好孝
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] レスベラトロールによる活性酸素の生成とアポトーシスの誘導2007
- Author(s)
  坪内凉子, 吉野恵子, 羽根田みや子, 細川好孝, 吉野昌孝(金城学院大)
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] キノリン誘導体のプロオキシダント機能 : ハロゲンの導入による活性酸素種生成能の低下2007
- Author(s)
  村上恵子, 羽根田みや子, 成瀬誠, 細川好孝, 吉野昌孝(金城学院大)
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] ピリジンカルボン酸遷移金属複合体による活性酸素の生成2007
- Author(s)
  村上恵子, 羽根田みや子, 細川好孝, 吉野昌孝
- Organizer
  第24回微量栄養素研究会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-19591143
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
- Author(s)
  太田明伸, Ekhtear Hossain, Sivasundaram Karnan, Shahnewaj Mannan, 小西裕之, 細川好孝
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都・京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] プランバギンは口腔扁平上皮癌に対して活性酸素産生を介した細胞増殖抑制効果を示す
- Author(s)
  太田明伸, Sivasundaram Karnan, 小西裕之, 風岡宜暁, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25640107
[Presentation] アデノ随伴ウイルスに基づく遺伝子改変ベクターにおいて薬剤耐性遺伝子の発現を制御するプロモーターと改変効率の関係
- Author(s)
  小西裕之, Sivasundaram Karnan, 太田明伸, 細川好孝
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25460395
[Presentation] NF1関連の皮膚神経線維腫における400KオリゴアレイCGH解析
- Author(s)
  Sivasundaram Karnan, 太田明伸, 小西裕之, 細川好孝
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川・横浜）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460395

1. NAKAMURA Shigeo (80180363)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KONISHI Hiroyuki (20344335)

# of Collaborated Projects: 3 results

# of Collaborated Products: 48 results
3. SETO Masao (80154665)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KEIKO Murakami (10139652)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. SIVASUNDARAM Karnan (30557096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
6. TANAKA Minoru (90024736)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. USHIRO Hiroshi (10151854)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAKASHIMA Kunio (40022800)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 太田明伸 (30438048)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. KAGAMI Yoshitoyo (30270721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山本雅 (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡田明子 (00233320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大場基 (70297018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 荒木令江 (80253722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 黒田昌宏 (50225306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 清野透 (10186356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 本間美和子 (40192538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 白澤専二 (10253535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 菊池章 (10204827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 生田和良 (60127181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 浜口道成 (90135351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 後藤典子 (10251448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 神田浩明 (90260067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 上出利光 (00160185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 秋山伸一 (60117413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 鈴木律朗 (20280810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 中尾春壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 中出幸臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 村上秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHITAKA Hosokawa 細川 好孝

細川 好孝 ホソカワ ヨシタカ

HOSOKAWA Yoshitaka 細川 好孝

Research Projects

Research Products

Co-Researchers

癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発Principal Investigator

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胸膜中皮腫の予後改善を目指した診断マーカーと阻害化合物の探索Principal Investigator

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Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line

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Development of a highly specific genome editing technology for human cells using adeno-associated viral vector

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Characterization of human BRCA1 heterozygous knockout cell lines created by somatic cell gene targeting

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Molecular mechanism of anti-apoptotic action in MALT lymphoma and clinical applicationPrincipal Investigator

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Molecular mechanism underlying anti-apoptotic action in MALT lymphoma and clinical applicationPrincipal Investigator

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Molecular analysis of anti-apoptotic action in MALT lymphoma and its clinical application for diagnosis and treatment.Principal Investigator

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Molecular analysis of malignant lymphoma-related oncogenes and its clinical application for diagnosis and treatment.Principal Investigator

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BCL6がん遺伝子とAPI2-MALT1融合遺伝子の機能解析と診断治療への応用Principal Investigator

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Molecular analysis of B-cell malignant lymphoma-related oncogenes and its clinical application for diagnosis and treatment.Principal Investigator

Principal Investigator

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BCL6がん遺伝子とAPI2-MALT1融合遺伝子の機能解析と診断治療への応用Principal Investigator

Principal Investigator

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Research Institution

リンパ腫瘍におけるサイクリンD1トランスクリプトbの役割と診断、治療への応用Principal Investigator

Principal Investigator

YOSHITAKA Hosokawa 細川好孝

細川好孝ホソカワヨシタカ

HOSOKAWA Yoshitaka 細川好孝