Ochi Hiroki 越智広樹

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OCHI Hiroki 越智広樹

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Researcher Number	30582283
Other IDs
Affiliation (Current)	2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2025: 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 研究員 2018 – 2019: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 2016 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2014 – 2016: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2012 – 2013: 日本獣医生命科学大学, 獣医学部, 助教 2010 – 2011: 慶應義塾大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 59010:Rehabilitation science-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56020:Orthopedics-related / Complex systems Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator 骨細胞 / 感覚神経 / 骨代謝 / 廃用性骨萎縮 / 神経 / マイクロRNA / 骨芽細胞 / リハビリテーション / 脊髄損傷 / グリア細胞 … More / メカニカルストレス / 組織透明化 / 筋サテライト細胞 / 筋萎縮 / 骨格筋 / 臓器間クロストーク / 臓器連関 / 成長ホルモン / RAS / レニン・アンジオテンシン / レニンアンギオテンシン系 / miRNA / 骨・軟骨代謝学 / 次世代シークエンサー … More Except Principal Investigator 組織透明化技術 / メカニカルストレス / 三次元イメージング / 整形外科 / 骨代謝 / 力学的刺激 / 脂肪性肝疾患 / 運動 / 感覚神経 / 宇宙実験 / 神経・血管系 / 臓器間ネットワーク / 骨・軟部腫瘍学 / 肉腫発症モデルマウス / 肉腫起源細胞 / 肉腫発症マウスモデル / 腫瘍起源細胞 / ペリサイト / 骨軟部腫瘍 / 多臓器連関 / 骨代謝学 / マイクロRNA / 骨転移 / 癌 / 骨・軟骨代謝学 Less

Bone homeostasis and mechanical stress response regulated by sensory nerves inside bone
- Principal Investigator
  
  佐藤信吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Institute of Science Tokyo
Elucidation of the mechanism of disuse osteopenia focusing on the regulation of osteocyte homeostasis by the sensory nervous systemPrincipal Investigator
- Principal Investigator
  
  越智広樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
運動模倣力学的刺激による脂肪性肝疾患改善の分子機序解明に基づく、運動の本質の理解
- Principal Investigator
  
  崎谷直義
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
神経・血管の視点から解き明かす筋骨格系の恒常性維持機構と筋骨格系疾患の新たな病態
- Principal Investigator
  
  佐藤信吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the pathophysiology of disuse osteoporosis with a focus on the interaction between sensory nerves and bone tissue.Principal Investigator
- Principal Investigator
  
  Ochi Hiroki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
The development of drugs that promote neurorehabilitation effects based on glial cell single cell analysis.Principal Investigator
- Principal Investigator
  
  Ochi Hiroki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Development of optical bone clearing technique and elucidation of pathophysiology of bone metabolic disorders focusing on neural-vascular network
- Principal Investigator
  
  Sato Shingo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Medical and Dental University
Evaluation of adaptation and response to mechanical stress in bone through sensory nervous system and osteocyte network.Principal Investigator
- Principal Investigator
  
  Ochi Hiroki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
  Tokyo Medical and Dental University
臓器連関の視点から俯瞰する筋・骨恒常性維持機構の解明－健康寿命増進治療法の開発－
- Principal Investigator
  
  TAKEDA Shu
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
感覚神経‐筋サテライト細胞という新規臓器連関が担う骨格筋恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  越智広樹
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University
骨恒常性維持に関わる血管-神経ネットワークの解明
- Principal Investigator
  
  竹田秀
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Pericyte as a novel cellular origin of sarcoma: Elucidating the mechanism of malignant transformation of pericyte and developing new therapeutic drugs for sarcoma
- Principal Investigator
  
  Sato Shingo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Identification of bone derived brain function regulating factor through bone-brain cross talk.Principal Investigator
- Principal Investigator
  
  Ochi Hiroki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Elucidation of renin-angiotensin system roles in osteocyte and development of novel osteogenic medication.Principal Investigator
- Principal Investigator
  
  Ochi Hiroki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
The effect of micro RNA in bone remodering.Principal Investigator
- Principal Investigator
  
  OCHI Hiroki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nippon Veterinary and Life Science University
MicroRNAs regulate cancer bone metastasis via exosomes.
- Principal Investigator
  
  SUNAMURA Satoko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
The effect of microRNA in osteocyte differentiation.Principal Investigator
- Principal Investigator
  
  OCHI Hiroki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Clinical Calcium ;特集骨・関節疾患の動物モデルI.骨粗鬆症8.骨粗鬆症研究のための遺伝子改変マウス2011
- Author(s)
  越智広樹、竹田秀
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22890178
[Book] O. li. v. e.-骨代謝と生活習慣病の連関;腸由来セロトニン合成の薬理学的阻害が骨粗鬆症の骨同化治療に使用できる可能性2011
- Author(s)
  越智広樹、竹田秀
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22890178
[Journal Article] L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.2023
- Author(s)
  Park G, Fukasawa K, Horie T, Masuo Y, Inaba Y, Tatsuno T, Yamada T, Tokumura K, Iwahashi S, Iezaki T, Kaneda K, Kato Y, Ishigaki Y, Mieda M, Tanaka T, Ogawa K, Ochi H, Sato S, Shi YB, Inoue H, Lee H, Hinoi E.
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 7
- DOI
  10.1172/jci.insight.154925
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06688, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455, KAKENHI-PROJECT-22K08660, KAKENHI-PROJECT-22K19545, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-21H04865, KAKENHI-PROJECT-23K24764, KAKENHI-PROJECT-23K27996
[Journal Article] SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption2023
- Author(s)
  Aobulikasimu Alkebaier、Liu Tao、Piao Jinying、Sato Shingo、Ochi Hiroki、Okawa Atsushi、Tsuji Kunikazu、Asou Yoshinori
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41598-023-33297-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19580, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455, KAKENHI-PROJECT-18H02920
[Journal Article] Regulation of Osteoblast to Osteocyte Differentiation by Cyclin‐Dependent Kinase‐12023
- Author(s)
  Tanaka Tomoyuki、Miyakoshi Yuri、Kobayashi Yutaka、Xiaolong Sun、Daiyang Yu、Ochi Hiroki、Sato Shingo、Kato Tsuyoshi、Yoshii Toshitaka、Okawa Atsushi、Kaldis Philipp、Inose Hiroyuki
- Journal Title
  
  Advanced Biology
  
  Volume: 7 Issue: 12
- DOI
  10.1002/adbi.202300136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0205, KAKENHI-PROJECT-22K09302, KAKENHI-PROJECT-22K09394, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455
[Journal Article] A Novel Long Noncoding RNA in Osteocytes Regulates Bone Formation through the Wnt/β-Catenin Signaling Pathway2023
- Author(s)
  Arai Makoto、Ochi Hiroki、Sunamura Satoko、Ito Nobuaki、Nangaku Masaomi、Takeda Shu、Sato Shingo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 17 Pages: 13633-13633
- DOI
  10.3390/ijms241713633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09293, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-21H03298, KAKENHI-PROJECT-23K24455
[Journal Article] Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation2023
- Author(s)
  Utagawa Kurando、Shin Takaei、Yamada Hironori、Ochi Hiroki、Sunamura Satoko、Unno Aiko、Akazawa Chihiro、Ema Masatsugu、Takeda Shu、Okawa Atsushi、Sato Shingo
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 4674-4674
- DOI
  10.1038/s41598-023-30492-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-23K24455, KAKENHI-PROJECT-21H03298
[Journal Article] Transcriptional coregulator Ess2 controls survival of post-thymic CD4+ T cells through the Myc and IL-7 signaling pathways2022
- Author(s)
  Takada Ichiro、Hidano Shinya、Takahashi Sayuri、Yanaka Kaori、Ogawa Hidesato、Tsuchiya Megumi、Yokoyama Atsushi、Sato Shingo、Ochi Hiroki、Nakagawa Tohru、Kobayashi Takashi、Nakagawa Shinichi、Makishima Makoto
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 9 Pages: 102342-102342
- DOI
  10.1016/j.jbc.2022.102342
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07984, KAKENHI-PROJECT-21K11439, KAKENHI-PROJECT-22K06082, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-20K07029, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-23K24455
[Journal Article] The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis2022
- Author(s)
  Yamada Takanori、Fukasawa Kazuya、Horie Tetsuhiro、Kadota Takuya、Lyu Jiajun、Tokumura Kazuya、Ochiai Shinsuke、Iwahashi Sayuki、Suzuki Akane、Park Gyujin、Ueda Rie、Yamamoto Megumi、Kitao Tatsuya、Shirahase Hiroaki、Ochi Hiroki、Sato Shingo、Iezaki Takashi、Hinoi Eiichi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Issue: 7 Pages: 1576-1588
- DOI
  10.1016/j.stemcr.2022.06.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-23K24455
[Journal Article] Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood2022
- Author(s)
  Horie Tetsuhiro、Fukasawa Kazuya、Yamada Takanori、Mizuno Seiya、Iezaki Takashi、Tokumura Kazuya、Iwahashi Sayuki、Sakai Shiho、Suzuki Akane、Kubo Takuya、Osumi Ryoma、Tomizawa Akane、Ochi Hiroki、Sato Shingo、Kaneda Katsuyuki、Takahashi Satoru、Hinoi Eiichi
- Journal Title
  
  Stem Cells
  
  Volume: - Issue: 4 Pages: 011-011
- DOI
  10.1093/stmcls/sxac011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19J21335, KAKENHI-PROJECT-21K15350, KAKENHI-PROJECT-21K20843, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-23K24455
[Journal Article] Foxf2 represses bone formation via Wnt2b/β-catenin signaling2022
- Author(s)
  Tanaka Tomoyuki、Takahashi Akira、Kobayashi Yutaka、Saito Masanori、Xiaolong Sun、Jingquan Chen、Ito Yoshiaki、Kato Tsuyoshi、Ochi Hiroki、Sato Shingo、Yoshii Toshitaka、Okawa Atsushi、Carlsson Peter、Inose Hiroyuki
- Journal Title
  
  Experimental & Molecular Medicine
  
  Volume: 54 Issue: 6 Pages: 753-764
- DOI
  10.1038/s12276-022-00779-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09302, KAKENHI-PROJECT-22K09394, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-20KK0205, KAKENHI-PROJECT-20H03800, KAKENHI-PROJECT-23K24455
[Journal Article] A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy.2021
- Author(s)
  Aihemaiti A, Yamamoto N, Piao J, Oyaizu T, Ochi H, Sato S, Okawa A, Miyata T, Tsuji K, Ezura Y, Asou Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 534 Pages: 849-856
- DOI
  10.1016/j.bbrc.2020.10.089
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09096, KAKENHI-PROJECT-19K22680, KAKENHI-PROJECT-18H02920, KAKENHI-PROJECT-18K19604, KAKENHI-PROJECT-19H03777, KAKENHI-PROJECT-21K19556
[Journal Article] Mechanical load regulates bone growth via periosteal Osteocrin2021
- Author(s)
  Watanabe-Takano H., Ochi H., Chiba A., Matsuo A., Kanai Y., Fukuhara S., Ito N., Sako K., Miyazaki T., Tainaka K., Harada I., Sato S., Sawada Y., Minamino N., Takeda S., Ueda H.R., Yasoda A., Mochizuki N.
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 2 Pages: 109380-109380
- DOI
  10.1016/j.celrep.2021.109380
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22517, KAKENHI-PROJECT-20K21246, KAKENHI-PROJECT-20K21778, KAKENHI-PUBLICLY-20H04700, KAKENHI-PROJECT-19H01022, KAKENHI-PROJECT-21H04866, KAKENHI-PROJECT-18H02105, KAKENHI-PROJECT-19H03777, KAKENHI-PROJECT-21H02665, KAKENHI-PROJECT-20K08877, KAKENHI-PROJECT-21K19358, KAKENHI-PROJECT-21K19556, KAKENHI-PROJECT-20K08414
[Journal Article] The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice.2020
- Author(s)
  Mieradili Mulati,Toshitaka Yoshii, Atsushi Okawa, Hiroyuki Inose
- Journal Title
  
  Bone
  
  Volume: 130 Pages: 115076-115076
- DOI
  10.1016/j.bone.2019.115076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09570, KAKENHI-PROJECT-19K22680, KAKENHI-PROJECT-19H03775, KAKENHI-PROJECT-19H03777
[Journal Article] Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy2020
- Author(s)
  Kobayashi Yutaka、Tanaka Tomoyuki、Mulati Mieradilli、Ochi Hiroki、Sato Shingo、Kaldis Philipp、Yoshii Toshitaka、Okawa Atsushi、Inose Hiroyuki
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 1-14
- DOI
  10.3389/fcell.2020.564581
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03775, KAKENHI-PROJECT-19H03777, KAKENHI-PROJECT-20H03800, KAKENHI-PROJECT-19K22680
[Journal Article] Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice2019
- Author(s)
  Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M
- Journal Title
  
  Bio Protoc.
  
  Volume: 9(3)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10847
[Journal Article] The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway2019
- Author(s)
  Ozaki Kakeru、Yamada Takanori、Horie Tetsuhiro、Ishizaki Atsushi、Hiraiwa Manami、Iezaki Takashi、Park Gyujin、Fukasawa Kazuya、Kamada Hikari、Tokumura Kazuya、Motono Mei、Kaneda Katsuyuki、Ogawa Kazuma、Ochi Hiroki、Sato Shingo、Kobayashi Yasuhiro、Shi Yun-Bo、Taylor Peter M.、Hinoi Eiichi
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 589 Pages: 589-589
- DOI
  10.1126/scisignal.aaw3921
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22680, KAKENHI-PUBLICLY-18H04971, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-19H03777, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-17J06262, KAKENHI-PROJECT-18J13309, KAKENHI-PROJECT-18J22107, KAKENHI-PROJECT-17KT0051, KAKENHI-ORGANIZER-15H05935
[Journal Article] Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing2019
- Author(s)
  Supakul Sopak、Yao Kenta、Ochi Hiroki、Shimada Tomohito、Hashimoto Kyoko、Sunamura Satoko、Mabuchi Yo、Tanaka Miwa、Akazawa Chihiro、Nakamura Takuro、Okawa Atsushi、Takeda Shu、Sato Shingo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 5 Pages: 1079-1079
- DOI
  10.3390/ijms20051079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06853, KAKENHI-PROJECT-16K10847, KAKENHI-PROJECT-19K07702, KAKENHI-PROJECT-19K22680, KAKENHI-PROJECT-19KK0216, KAKENHI-PROJECT-19H01035, KAKENHI-PROJECT-19H03777
[Journal Article] A small molecule PAI-1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency-induced osteoporosis model2018
- Author(s)
  Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Sato S, Ochi H, Tsuji K, Nakabayashi T, Miyata T, Okawa A, Asou Y.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8(4) Issue: 4 Pages: 523-532
- DOI
  10.1002/2211-5463.12390
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847, KAKENHI-PROJECT-17K11000, KAKENHI-PROJECT-26293332
[Journal Article] Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A2018
- Author(s)
  Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Nobuyoshi Kosaka, Yo Mabuchi, Toru Fukuda, Kenta Yao, Hiroaki Kanda, Keisuke Ae, Atsushi Okawa, Chihiro Akazawa, Takahiro Ochiya, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 115(9) Issue: 9 Pages: 2204-2209
- DOI
  10.1073/pnas.1717363115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10847, KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-15K06837, KAKENHI-PROJECT-17K01753, KAKENHI-PROJECT-15K06853
[Journal Article] Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone.2018
- Author(s)
  Takahashi A, Mulati M, Saito M, Numata H, Kobayashi Y, Ochi H, Sato S, Kaldis P, Okawa A, Inose H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 293 Issue: 50 Pages: 19387-19399
- DOI
  10.1074/jbc.ra118.004834
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05681, KAKENHI-PROJECT-16K10847
[Journal Article] WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.2017
- Author(s)
  Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.
- Journal Title
  
  EBioMedicine
  
  Volume: 18 Pages: 118-27
- DOI
  10.1016/j.ebiom.2017.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15H06184, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-17K16077, KAKENHI-PUBLICLY-17H05500, KAKENHI-PROJECT-15K09423, KAKENHI-PROJECT-16K15234
[Journal Article] Antiretroviral therapy containing HIV protease inhibitors enhances fracture risk by impairing osteoblast differentiation and bone quality2017
- Author(s)
  Hirakawa H, Gatanaga H, Ochi H, Fukuda T, Sunamura S, Oka S, Takeda S, Sato S.
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 215(12) Issue: 12 Pages: 1893-1897
- DOI
  10.1093/infdis/jix246
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847, KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-17J07892
[Journal Article] Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.2017
- Author(s)
  Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: 32 Issue: 4 Pages: 872-881
- DOI
  10.1002/jbmr.3053
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-17H04399, KAKENHI-PROJECT-16H06825
[Journal Article] Circadian Clock Regulates Bone Resorption in Mice. Circadian Clock Regulates Bone Resorption in Mice.2016
- Author(s)
  Xu C, Ochi H, Fukuda T, Sato S, Sunamura S, Takarada T, Hinoi E, Okawa A, Takeda S.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: - Issue: 7 Pages: 1344-1355
- DOI
  10.1002/jbmr.2803
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15543, KAKENHI-PROJECT-25253090, KAKENHI-PROJECT-26893068, KAKENHI-PROJECT-25462381, KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-26460387, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-16K10847
[Journal Article] Circadian Clock Regulates Bone Resorption in Mice.2016
- Author(s)
  Xu C, Ochi H, Fukuda T, Sato S, Sunamura S, Takarada T, Hinoi E, Okawa A, Takeda S.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15545
[Journal Article] Pleiotropic Functions of High Fat Diet in the Etiology of Osteoarthritis.2016
- Author(s)
  Asou Y, Iwata M, Ochi H, Ailixiding M, Aibibula Z, Piao J, Jin G, Hara Y, Okawa A.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 9 Pages: e0162794-e0162794
- DOI
  10.1371/journal.pone.0162794
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01633, KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-15K15541, KAKENHI-PROJECT-26293332
[Journal Article] Circadian Clock Regulates Bone Resorption in Mice.2016
- Author(s)
  Xu C, Ochi H, Fukuda T, Sato S, Sunamura S, Takarada T, Hinoi E, Okawa A, Takeda S.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: 31(7): Pages: 1344-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02677
[Journal Article] Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.2015
- Author(s)
  Chengshan Ma, Toru Fukuda, Hiroki Ochi, Satoko Sunamura, Cheng Xu, Ren Xu, Atsushi Okawa, Shu Takeda
- Journal Title
  
  Mol Metab
  
  Volume: 4 Issue: 3 Pages: 175-185
- DOI
  10.1016/j.molmet.2015.01.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25253090, KAKENHI-PROJECT-15K15543, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-26713048
[Journal Article] A Comparison of the Process of Remodeling of Hydroxyapatite/Poly-D/L-Lactide and Beta-Tricalcium Phosphate in a Loading Site.2015
- Author(s)
  Akagi H, Ochi H, Soeta S, Kanno N, Yoshihara M, Okazaki K, Yogo T, Harada Y, Amasaki H, Hara Y.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 730105-730105
- DOI
  10.1155/2015/730105
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-26713048
[Journal Article] MicroRNA-145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb.2015
- Author(s)
  Fukuda T, Ochi H, Sunamura S, Haiden A, Bando W, Inose H, Okawa A, Asou Y, Takeda S.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 21 Pages: 3302-8
- DOI
  10.1016/j.febslet.2015.09.024
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15543, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-25253090, KAKENHI-PROJECT-25462381, KAKENHI-PROJECT-26293332, KAKENHI-PROJECT-26713048
[Journal Article] Bone morphogenetic protein 4 and bone morphogenetic protein receptor expression in the pituitary gland of adult dogs in healthy condition and with ACTH-secreting pituitary adenoma.2015
- Author(s)
  Sato A, Ochi H, Harada Y, Yogo T, Kanno N, Hara Y.
- Journal Title
  
  Domest Anim Endocrinol.
  
  Volume: - Pages: 126-133
- DOI
  10.1016/j.domaniend.2015.09.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15545
[Journal Article] Hydroxyapatite/poly-L-lactide acid screws have better biocompatibility and femoral burr hole closure than does poly-L-lactide acid alone2014
- Author(s)
  Akagi H, Iwata M, Ichinohe T, Amimoto H, Hayashi Y, Kannno N, Ochi H, Fujita Y, Harada Y, Tagawa M, Hara Y
- Journal Title
  
  J Biomater Appl
  
  Volume: 28(6) Issue: 6 Pages: 954-62
- DOI
  10.1177/0885328213487754
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Antimicrobial susceptibility of enterococcal species isolated from antibiotic-treated dogs and cats.2014
- Author(s)
  Kataoka Y, Umino Y, Ochi H, Harada K, Sawada T.
- Journal Title
  
  J Vet Med Sci
  
  Volume: 76 Pages: 1399-1402
- NAID
  130004704115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26713048
[Journal Article] Tibial displacement with stifle joint flexion and cranial cruciate ligament transection in the dog. An ex vivo study using a robotic simulator.2014
- Author(s)
  Kanno N, Hara Y, Fukano S, Fujie H, Ochi H, Fujita Y, Yasuji H, Nezu Y, Yogo T, Tagawa M
- Journal Title
  
  Vet Comp Orthop Traumatol
  
  Volume: 27 Issue: 04 Pages: 277-284
- DOI
  10.3415/vcot-13-06-0080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713048
[Journal Article] The Two Sides of Vitamin E Supplementation.2014
- Author(s)
  Ochi H, Takeda S.
- Journal Title
  
  Gerontology
  
  Volume: - Issue: 4 Pages: 319-26
- DOI
  10.1159/000366419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713048, KAKENHI-PROJECT-15K15543, KAKENHI-PROJECT-15K15545, KAKENHI-PROJECT-25253090
[Journal Article] Identification and Antimicrobial Susceptibility of Enterococci Isolated from Dogs and Cats Subjected to Differing Antibiotic Pressures.2013
- Author(s)
  Kataoka Y, Ito C, Sasaki A, Ishii M, Yamashiro S, Harada K, Ochi H, Sawada T.
- Journal Title
  
  J Vet Med Sci.
  
  Volume: 75 Pages: 749-53
- NAID
  130003362112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Variations in Gene and Protein Expression in Canine Chondrodystrophic Nucleus Pulposus Cells following Long-Term Three-Dimensional Culture.2013
- Author(s)
  Iwata M, Ochi H, Asou Y, Haro H, Aikawa T, Harada Y, Nezu Y, Yogo T, Tagawa M, Hara Y.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 5 Pages: e63120-e63120
- DOI
  10.1371/journal.pone.0063120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H+-ATPase biogenesis2013
- Author(s)
  Kinouchi et al
- Journal Title
  
  Plos One
  
  Volume: 8 Issue: 11 Pages: e78603-e78603
- DOI
  10.1371/journal.pone.0078603
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25293198, KAKENHI-PROJECT-25650066
[Journal Article] Clinical efficacy of autogenous cancellous bone and fibroblast growth factor 2 combined with frozen allografts in femoral nonunion fractures.2013
- Author(s)
  Akagi H, Ochi H, Kannno N, Iwata M, Ichinohe T, Harada Y, Nezu Y, Yogo T, Tagawa M, Hara Y.
- Journal Title
  
  Vet Comp Orthop Traumatol
  
  Volume: 26 Issue: 02 Pages: 123-9
- DOI
  10.3415/vcot-11-12-0186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Identification and Antimicrobial Susceptibility of Enterococci Isolated from Dogs and Cats Subjected to Differing Antibiotic Pressures2013
- Author(s)
  Kataoka Y, Ito C, Sasaki A, Ishii M, Yamashiro S, Harada K, Ochi H, Sawada T
- Journal Title
  
  J Vet Med Sci
  
  Volume: 75(6) Pages: 749-53
- NAID
  130003362112
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model : Pivotal Role of the IPFP as a Cytokine Fountain2013
- Author(s)
  Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y
- Journal Title
  
  PLoS One
  
  Volume: 12;8(4)(Print)
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Clinical efficacy of autogenous cancellous bone and fibroblast growth factor 2 combined with frozen allografts in femoral nonunion fractures2013
- Author(s)
  Akagi H, Ochi H, Kannno N, Iwata M, Ichinohe T, Harada Y, Nezu Y, Yogo T, Tagawa M, Hara Y
- Journal Title
  
  Vet Comp Orthop Traumatol
  
  Volume: 15;26(2) Pages: 123-9
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Sema3A regulates bone-mass accrual through sensory innervations2013
- Author(s)
  Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H
- Journal Title
  
  Nature.
  
  Volume: 497 Issue: 7450 Pages: 490-493
- DOI
  10.1038/nature12115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22600011, KAKENHI-PROJECT-24500447, KAKENHI-PROJECT-24592188, KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25670637
[Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain.2013
- Author(s)
  Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 4 Pages: e60706-e60706
- DOI
  10.1371/journal.pone.0060706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25462361, KAKENHI-PROJECT-25670637
[Journal Article] An analysis of skeletal development in osteoblast- and chondrocyte-specific Runx2 knockout mice2013
- Author(s)
  Takeshi Takarada, Eiichi Hinoi, Ryota Nakazato, Hiroki Ochi, Cheng Xu, Azusa Tsuchikane, Shu Takeda, Gerard Karsenty, Takaya Abe, Hiroshi Kiyonari, and Yukio Yoneda
- Journal Title
  
  J. Bone Miner. Res
  
  Volume: 未定 Issue: 10 Pages: 2064-9
- DOI
  10.1002/jbmr.1945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500330, KAKENHI-PROJECT-23689004, KAKENHI-PROJECT-24650196, KAKENHI-PROJECT-24791565
[Journal Article] Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.2013
- Author(s)
  Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.
- Journal Title
  
  Ｓｃｉｅｎｔｉｆｉｃ　Ｒｅｐｏｒｔ
  
  Volume: october 23 Issue: 1 Pages: 3022-3022
- DOI
  10.1038/srep03022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791565, KAKENHI-PROJECT-25462360, KAKENHI-PROJECT-25670637
[Journal Article] Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament.2012
- Author(s)
  Iwasaki M, Piao J, Kimura A, Sato S, Inose H, Ochi H, Asou Y, Shinomiya K, Okawa A, Takeda S.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 8 Pages: e43372-e43372
- DOI
  10.1371/journal.pone.0043372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791627, KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791565
[Journal Article] Evaluation of the association between runt-related transcription factor 2 expression and intervertebral disk aging in dogs.2012
- Author(s)
  Itoh H, Hara Y, Tagawa M, Kato T, Ochi H, Koga D, Okawa A, Asou Y.
- Journal Title
  
  Am J Vet Res.
  
  Volume: 73 Pages: 1553-1559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012
- Author(s)
  Fujita K, Iwasaki M, Ochi H, Fukuda T, Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S
- Journal Title
  
  Nat Med
  
  Volume: 18(4) Pages: 589-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890178
[Journal Article] Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament2012
- Author(s)
  Iwasaki M, Piao J, Kimura A, Sato S, Inose H, Ochi H, Asou Y, Shinomiya K, Okawa A, Takeda S
- Journal Title
  
  PLoS One
  
  Volume: 7(8)
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model2012
- Author(s)
  Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y
- Journal Title
  
  PLoS One
  
  Volume: 7(5)
- Data Source
  KAKENHI-PROJECT-24791565
[Journal Article] Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia2012
- Author(s)
  Hinoi E, Ochi H, Takarada T, Nakatani E, Iezaki T, Nakajima H, Fujita H, Takahata Y, Hidano S, Kobayashi T, Takeda S, Yoneda Y
- Journal Title
  
  J Bone Miner Res
  
  Volume: 27(4) Pages: 938-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890178
[Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012
- Author(s)
  Fujita K, et al
- Journal Title
  
  Nat Med
  
  Volume: 18 Issue: 4 Pages: 589
- DOI
  10.1038/nm.2659
- URL
  https://localhost/en/publications/fc70e750-6e59-4813-bc13-47059a99d642
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689040, KAKENHI-PROJECT-22890178, KAKENHI-PUBLICLY-23113707, KAKENHI-PROJECT-23227004, KAKENHI-PROJECT-23659715, KAKENHI-PROJECT-24591530
[Journal Article] Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model.2012
- Author(s)
  Aini H, Ochi H, Iwata M, Okawa A, Koga D, Okazaki M, Sano A, Asou Y.
- Journal Title
  
  PLoS One
  
  Volume: 7(5) Issue: 5 Pages: e37728-e37728
- DOI
  10.1371/journal.pone.0037728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592257, KAKENHI-PROJECT-24791565
[Journal Article] Effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs2011
- Author(s)
  Ochi H, Hara Y, Asou Y, Harada Y, Nezu Y, Yogo T, Shinomiya K, Tagawa M
- Journal Title
  
  Am J Vet Res
  
  Volume: 72(5) Pages: 634-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890178
[Journal Article] Runx2 expression correlates with the degree of disc aging : a comparison between Magnetic Resonance Imaging and Runx2 expression
- Author(s)
  Itoh H, Hara Y, Tagawa M, Kato T, Ochi H, Koga D, Okawa A, Shinomiya K, Asou Y
- Journal Title
  
  Am J Vet Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890178
[Presentation] 骨透明化技術の開発による骨内神経の３次元構造の可視化と除神経による骨恒常性変化の観察2021
- Author(s)
  佐藤信吾、秦宇英、歌川蔵人、越智広樹、大川淳
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03777
[Presentation] 骨を透明にする技術の開発と宇宙実験への応用2021
- Author(s)
  佐藤信吾、秦宇英、歌川蔵人、越智広樹、砂村聡子、海野愛子、三宅智、大川淳
- Organizer
  第19回関東骨軟部腫瘍の基礎を語る会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03777
[Presentation] 骨転移におけるがん細胞と骨の細胞とのコミュニケーション2020
- Author(s)
  佐藤信吾、橋本恭子、越智広樹、大川淳、三宅智
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03777
[Presentation] ペリサイト（血管周皮細胞）は多分化能を有し骨折治癒に貢献する2019
- Author(s)
  佐藤信吾、Supakul Sopak、八尾健太、越智広樹、橋本恭子、砂村聡子、竹田秀、大川淳
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03777
[Presentation] 骨細胞の長鎖ノンコーディングRNAによる骨代謝制御機構の解明2019
- Author(s)
  佐藤信吾、荒井誠、越智広樹、砂村聡子、竹田秀、大川淳
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03777
[Presentation] がん細胞由来分泌型マイクロRNAによる骨転移微小環境制御機構2018
- Author(s)
  佐藤信吾, 橋本恭子, 越智広樹, 砂村聡子, 小坂展慶, 馬渕洋, 神田浩明, 阿江啓介, 小柳広高, 赤澤智宏, 落谷孝広, 二口充, 竹田秀, 大川淳
- Organizer
  第1回日本サルコーマ治療研究学会（JSTAR）学術集会
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] Cancer-secreted Hsa-miR-940 Induces Osteoblastic Phenotype in the Bone Metastatic Microenvironment2018
- Author(s)
  Shingo Sato, Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda
- Organizer
  Orthopaedic Research Society Annual Meeting 2014
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] がん細胞由来分泌型マイクロRNAによる骨転移微小環境制御機構2018
- Author(s)
  佐藤信吾, 橋本恭子, 越智広樹, 砂村聡子, 小坂展慶, 馬渕洋, 神田浩明, 阿江啓介, 小柳広高, 赤澤智宏, 落谷孝広, 二口充, 竹田秀, 大川淳
- Organizer
  第1回日本サルコーマ治療研究学会（JSTAR）学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2018
- Author(s)
  橋本恭子、越智広樹、砂村聡子、小坂展慶、馬渕洋、福田亨、八尾健太、神田浩明、阿江啓介、大川淳、赤澤智宏、落谷孝広、二口充、竹田秀、佐藤信吾
- Organizer
  第3回日本骨免疫学会ウインターセミナー
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞由来分泌型マイクロRNA による骨転移微小環境制御機構の解明2018
- Author(s)
  橋本恭子, 越智広樹, 砂村聡子, 小坂展慶, 大川淳, 落谷孝広, 二口充, 竹田秀, 佐藤信吾
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] ペリサイト（血管周皮細胞）は多分化能を有し骨折治癒に貢献する2018
- Author(s)
  佐藤信吾, Supakul Sopak, 島田智仁, 越智広樹, 馬渕洋, 八尾健太, 砂村聡子, 赤澤智宏, 中村卓郎, 竹田秀, 大川淳
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2018
- Author(s)
  橋本恭子、越智広樹、砂村聡子、小坂展慶、馬渕洋、福田亨、八尾健太、神田浩明、阿江啓介、大川淳、赤澤智宏、落谷孝広、二口充、竹田秀、佐藤信吾
- Organizer
  第3回日本骨免疫学会ウインターセミナー
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] Osteocyte Sirt6 has crucial roles in bone and phosphate metabolism2018
- Author(s)
  Alkebaier Aobulikasimu, Zulipiya Aibibula, Jinying Piao, Shingo Sato, Hiroki Ochi, Kunikazu Tsuji, Atsushi Okawa, Yoshinori Asou
- Organizer
  American Society for Bone and Mineral Research (ASBMR) 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] Cancer-secreted Hsa-miR-940 Induces Osteoblastic Phenotype in the Bone Metastatic Microenvironment2018
- Author(s)
  Shingo Sato, Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda
- Organizer
  Orthopaedic Research Society Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] 骨細胞のSirt6 はSOST 発現を介して骨代謝を制御する2018
- Author(s)
  Aobulikasimu Alkebaier, Aibibula Zulipiya, 朴金瑛, 金光文, 越智広樹, 佐藤信吾, 大川淳, 麻生義則
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] サーチュイン遺伝子Sirt6 によるリン代謝制御機構2018
- Author(s)
  麻生義則, 朴金瑛, Zulipiya Aibibula, 越智広樹, 佐藤信吾, 大川淳
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] HIV感染者に対する多剤併用療法は骨質の低下を介して骨折リスクを増加させる2017
- Author(s)
  平川弘幸、潟永博之、越智広樹、橋本恭子、砂村聡子、岡慎一、竹田秀、佐藤信吾
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] 感覚神経‐筋サテライト細胞という新規臓器連関が担う骨格筋恒常性維持機構の解明2017
- Author(s)
  越智広樹
- Organizer
  新学術領域研究　宇宙に生きる　H29年度第1回全体会議
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] HIV感染者に対する多剤併用療法は骨質の低下を介して骨質リスクを増加させる2017
- Author(s)
  平川弘幸、潟永博之、越智広樹、橋本恭子、砂村聡子、岡慎一、竹田秀、佐藤信吾
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment2017
- Author(s)
  Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  American Society of Bone and Mineral Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞が分泌するマイクロRNAが骨転移のタイプを規定する～造骨型骨転移を惹起する分泌型マイクロRNAの同定～2017
- Author(s)
  佐藤信吾, 橋本恭子, 砂村聡子, 越智広樹, 小柳広高, 二口充, 大川淳
- Organizer
  第50回日本整形外科学会骨軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] 新規PAI-1阻害剤はマウス骨髄除去モデルにおいて骨形成を促進する2017
- Author(s)
  Aobulikasimu Alkebaier, 金光文, 朴金瑛, Zulipiya Aibibula, 段孝, 市村敦彦, 宮田敏男, 越智広樹, 佐藤信吾, 大川淳, 麻生義則
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment2017
- Author(s)
  Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  American Society of Bone and Mineral Research 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] HIVに対する多剤併用療法は骨質の低下を介して骨折リスクを増加させる2017
- Author(s)
  佐藤信吾, 平川弘幸, 越智広樹, 橋本恭子, 砂村聡子, 岡慎一, 大川淳, 竹田秀, 潟永博之
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2017
- Author(s)
  橋本恭子、砂村聡子、越智広樹、大川淳、二口充、竹田秀、佐藤信吾
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment2017
- Author(s)
  Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  14th Meeting of Bone Biology Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] Cancer-secreted hsa-miR-940 induces osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A2017
- Author(s)
  Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Toru Fukuda, Kenta Yao, Yo Mabuchi, Atsushi Okawa, Chihiro Akazawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  ERATO/AMED-CREST/PRESTO Joint International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2017
- Author(s)
  橋本恭子、砂村聡子、越智広樹、大川淳、二口充、竹田秀、佐藤信吾
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] Cancer-secreted hsa-miR-940 induces osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A2017
- Author(s)
  Kyoko Hashimoto, Hiroki Ochi, Satoko Sunamura, Toru Fukuda, Kenta Yao, Yo Mabuchi, Atsushi Okawa, Chihiro Akazawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  ERATO/AMED-CREST/PRESTO Joint International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2017
- Author(s)
  橋本恭子、砂村聡子、越智広樹、大川淳、二口充、竹田秀、佐藤信吾
- Organizer
  第17回東京骨関節フォーラム
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] 新規PAI-1阻害薬は閉経後骨粗鬆症モデルの骨密度を回復させる2017
- Author(s)
  金光文, 朴英瑛, Aobulikasimu Alkebaier, Zulipiya Aibibula, 段孝, 市村敦彦, 赤堀浩司, 宮田敏男, 越智広樹, 佐藤信吾, 大川淳, 麻生義則
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する2017
- Author(s)
  橋本恭子、砂村聡子、越智広樹、大川淳、二口充、竹田秀、佐藤信吾
- Organizer
  第17回東京骨関節フォーラム
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment2017
- Author(s)
  Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato
- Organizer
  14th Meeting of Bone Biology Forum
- Data Source
  KAKENHI-PUBLICLY-16H01633
[Presentation] HIVに対する多剤併用療法は骨質の低下を介して骨折リスクを増加させる2017
- Author(s)
  佐藤信吾, 平川弘幸, 越智広樹, 橋本恭子, 砂村聡子, 岡慎一, 大川淳, 竹田秀, 潟永博之
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] 臓器連関の視点から俯瞰した骨の老化の新たなメカニズム2016
- Author(s)
  佐藤信吾, 越智広樹, 竹田秀
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] 骨を基軸とする臓器間ネットワーク機構2016
- Author(s)
  佐藤信吾, 越智広樹, 竹田秀
- Organizer
  第20回日本心血管内分泌代謝学会（CVMW 2016）
- Place of Presentation
  東京コンベンションホール（東京都中央区）
- Year and Date
  2016-12-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10847
[Presentation] グレリンは骨芽細胞に作用し骨形成を促進する2014
- Author(s)
  越智広樹、馬　成山、福田　亨、砂村聡子、大川　淳、竹田　秀
- Organizer
  第14回東京骨関節フォーラム
- Place of Presentation
  昭和大学（東京都、品川区）
- Year and Date
  2014-07-19
- Data Source
  KAKENHI-PROJECT-26713048
[Presentation] ビタミンEは破骨細胞融合を促進し骨量減少を引き起こす2011
- Author(s)
  越智広樹
- Organizer
  第13回骨粗鬆症学会骨ドック・検診分科会
- Place of Presentation
  神戸
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22890178
[Presentation] グレリンは骨芽細胞に作用し骨形成を促進する
- Author(s)
  越智広樹、馬　成山、福田　亨、砂村聡子、大川　淳、竹田　秀
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府、大阪市）
- Year and Date
  2014-07-21 – 2014-07-23
- Data Source
  KAKENHI-PROJECT-26713048

1. Sato Shingo (40462220)

# of Collaborated Projects: 9 results

# of Collaborated Products: 34 results
2. TAKEDA Shu (30376727)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. SUNAMURA Satoko (20570386)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. FUKUDA Toru (20301492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 崎谷直義 (30824859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 土屋吉史 (20795679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木戸康平 (50822730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 土田和可子 (90610014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SOPAK Supakul

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. YAO kenta

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. ASOU Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. SATO Momoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. YOSHII Toshitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. INOSE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 木村文子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小林隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 増尾友佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 福原茂朋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 大川淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. 檜井栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 宝田剛志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 伊東伸朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 辻邦和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 赤澤智宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 馬渕洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ochi Hiroki 越智 広樹

OCHI Hiroki 越智 広樹

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Elucidation of the mechanism of disuse osteopenia focusing on the regulation of osteocyte homeostasis by the sensory nervous systemPrincipal Investigator

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Elucidation of the pathophysiology of disuse osteoporosis with a focus on the interaction between sensory nerves and bone tissue.Principal Investigator

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The development of drugs that promote neurorehabilitation effects based on glial cell single cell analysis.Principal Investigator

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Evaluation of adaptation and response to mechanical stress in bone through sensory nervous system and osteocyte network.Principal Investigator

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感覚神経‐筋サテライト細胞という新規臓器連関が担う骨格筋恒常性維持機構の解明Principal Investigator

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Identification of bone derived brain function regulating factor through bone-brain cross talk.Principal Investigator

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Elucidation of renin-angiotensin system roles in osteocyte and development of novel osteogenic medication.Principal Investigator

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Ochi Hiroki 越智広樹

OCHI Hiroki 越智広樹