Toyota Tomoko 豊田知子

Researcher Number	30596432
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2023: 産業医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator mTOR / 神経変性 / てんかん / beclin-1 / 蛋白質分解 / ケンペロール / フラボノール / オートファジー / 進行性ミオクローヌスてんかん / 歯状核赤核淡蒼球ルイ体萎縮症 / ポリグルタミン病 / 神経変性疾患 … More Except Principal Investigator … More 凝集体形成抑制 / 病因蛋白質の選択的な分解 / オートファジー / 運動ニューロン疾患 / 神経変性 / 毒性軽減 / 分子シャペロン / HIKESHI / 歯状核赤核淡蒼球ルイ体萎縮症 / 球脊髄性筋萎縮症 / ポリグルタミン病 Less

Reducing toxicity of disease-causative molecules with the aim of developing therapies for neurodegenerative diseases
- Principal Investigator
  
  足立弘明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
The development of disease- modifying therapies for progressive myoclonus epilepsyPrincipal Investigator
- Principal Investigator
  
  Toyota Tomoko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Reducing toxicity of disease-causative molecules with the aim of developing therapies for neurodegenarative diseases
- Principal Investigator
  
  Adachi Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer’s disease.2024
- Author(s)
  Qiang Q, Skudder-Hill L, Toyota T, Huang Z, Wei W, Adachi H.
- Journal Title
  
  J Neurol Sci
  
  Volume: 457 Pages: 122861-122861
- DOI
  10.1016/j.jns.2023.122861
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06976
[Journal Article] CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer’s disease.2023
- Author(s)
  Qiang Q, Skudder-Hill L, Toyota T, Wei W, Adachi H.
- Journal Title
  
  Brain Communications
  
  Volume: 5 Issue: 6
- DOI
  10.1093/braincomms/fcad312
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06976
[Journal Article] Complete SAMD12 repeat expansion sequencing in a four-generation BAFME1 family with anticipation2023
- Author(s)
  Mizuguchi T., Toyota T., Koshimizu E., Kameyama S., Fukuda H., Tsuchida N., Uchiyama Y., Hamanaka K., Fujita A., Misawa K., Miyatake S., Adachi H. and Matsumoto N.
- Journal Title
  
  J Hum Genet
  
  Volume: 68 Issue: 12 Pages: 875-878
- DOI
  10.1038/s10038-023-01187-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18278, KAKENHI-PROJECT-22K15901, KAKENHI-PROJECT-21K07869, KAKENHI-PROJECT-23K06976, KAKENHI-PROJECT-23K07229, KAKENHI-PROJECT-23K27520, KAKENHI-PROJECT-23K27568
[Journal Article] 良性成人型家族性ミオクローヌスてんかんの臨床所見及び脳波所見の特徴2023
- Author(s)
  豊田知子, 足立弘明
- Journal Title
  
  Japanese Journal of Clinical Neurophysiology
  
  Volume: 51 Issue: 2 Pages: 42-50
- DOI
  10.11422/jscn.51.42
- ISSN
  1345-7101, 2188-031X
- Year and Date
  2023-04-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15704, KAKENHI-PROJECT-23K06976
[Journal Article] CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer’s disease.2022
- Author(s)
  Qiang Q, Skudder-Hill L, Toyota T, Wei W, Adachi H.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 17392-17392
- DOI
  10.1038/s41598-022-20324-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15704
[Journal Article] Complete sequencing of expanded SAMD12 repeats by long-read sequencing with Cas9-mediated enrichment.2021
- Author(s)
  Mizuguchi T, Toyota T, Miyatake S, Mitsuhashi S, Doi H, Kudo Y, Kishida H, Hayashi N, Tusburaya RS, Kinoshita M, Fukuyama T, Fukuda H, Koshimizu E, Tsuchida N, Uchiyama Y, Fujita A, Takata A, Miyake N, Kato M, Tanaka F, Adachi H, Matsumoto N.
- Journal Title
  
  Brain
  
  Volume: 144 Issue: 4 Pages: 1103-1117
- DOI
  10.1093/brain/awab021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07970, KAKENHI-PLANNED-20H05777, KAKENHI-PROJECT-19H03621, KAKENHI-PROJECT-21H02855, KAKENHI-PROJECT-20K07907, KAKENHI-PROJECT-20K08164, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-21K07298, KAKENHI-PROJECT-21K15704
[Journal Article] Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis2020
- Author(s)
  Masaki Hiromi、Watanabe Keita、Kakeda Shingo、Ide Satoru、Sugimoto Kohichiro、Ueda Issei、Hamamura Toshihiko、Hisanaga Sachi、Toyota Tomoko、Akamatsu Naoki、Shimajiri Shohei、Yamamoto Junkoh、Nishizawa Shigeru、Adachi Hiroaki、Korogi Yukunori
- Journal Title
  
  Japanese Journal of Radiology
  
  Volume: 38 Issue: 11 Pages: 1020-1027
- DOI
  10.1007/s11604-020-01019-y
- NAID
  50014626761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07970
[Journal Article] Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads2019
- Author(s)
  Satomi Mitsuhashi, Martin C. Frith, Takeshi Mizuguchi, Satoko Miyatake, Tomoko Toyota, Hiroaki Adachi, Yoko Oma, Yoshihiro Kino, Hiroaki Mitsuhashi, Naomichi Matsumoto
- Journal Title
  
  Genome Biology
  
  Volume: 20 Issue: 1 Pages: 58-58
- DOI
  10.1186/s13059-019-1667-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09683, KAKENHI-PROJECT-17K10080, KAKENHI-PUBLICLY-17H05708, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17K15630, KAKENHI-PROJECT-19K07970
[Journal Article] Detecting a long insertion variant in SAMD12 by SMRT sequencing: implications of long-read whole-genome sequencing for repeat expansion diseases2018
- Author(s)
  Mizuguchi Takeshi、Toyota Tomoko、Adachi Hiroaki、Miyake Noriko、Matsumoto Naomichi、Miyatake Satoko
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 64 Issue: 3 Pages: 191-197
- DOI
  10.1038/s10038-018-0551-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10080, KAKENHI-PUBLICLY-17H05708, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17K15630, KAKENHI-PROJECT-19K07970
[Presentation] Kaempferol promotes the degradation of mutant proteins via a novel mTOR-dependent autophagic pathway2023
- Author(s)
  足立弘明、黄哲、豊田知子、勝野雅央、祖父江元
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06976
[Presentation] 神経変性疾患の病因蛋白質の分解亢進による予防2023
- Author(s)
  足立弘明、黄哲、豊田知子
- Organizer
  第5回日本脳サプリメント学会
- Data Source
  KAKENHI-PROJECT-23K06976
[Presentation] Kaempferol promotes the degradation of mutant proteins via a novel mTOR-dependent autophagic pathway2023
- Author(s)
  Adachi H, Huang Z, Toyota T, Qiang Q, Katsuno M, Sobue G
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06976
[Presentation] Kaempferol promotes the degradation of mutant proteins via a novel mTOR-dependent autophagic pathway2023
- Author(s)
  足立弘明、黄哲、豊田知子、勝野雅央、祖父江元
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-23K06976
[Presentation] Emodin alleviates SBMA phenotype via down regulation of androgen receptor2022
- Author(s)
  Hiroaki Adachi, Qiang Qiang, Zhe Huang, Tomoko Toyota, Masahisa Katsuno, Gen Sobue
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] Clinical and electroencephalographic features of benign adult familial myoclonic epilepsy2022
- Author(s)
  Tomoko Toyota
- Organizer
  第52回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] Emodin alleviates SBMA phenotype via down regulation of androgen receptor2022
- Author(s)
  Hiroaki Adachi, Qiang Qiang, Tomoko Toyota, Masahisa Katsuno, Gen Sobue
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] Emodin alleviates SBMA phenotype via down regulation of androgen receptor2022
- Author(s)
  Hiroaki Adachi, Qiang Qiang, Tomoko Toyota, Masahisa Katsuno, Gen Sobue
- Organizer
  第45回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] 神経変性疾患の病因蛋白質の分解亢進による治療2022
- Author(s)
  足立弘明、黄哲、豊田知子
- Organizer
  第16回　日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] Perampanel improves the epilepsy phenotype by the phosphorylation of GluA1 in the DRPLA transgenic mice2021
- Author(s)
  Tomoko Toyota, Zhe Huang, Kazumasa Okada, Toshiya Sato, Shoji Tsuji, Hiroaki Adachi
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Perampanel improves the epilepsy phenotype by the phosphorylation of GluA1 in the DRPLA transgenic mice2021
- Author(s)
  豊田知子、黄哲、岡田和将、佐藤俊哉、辻省二、足立弘明
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15704
[Presentation] TFEB over-expression reduces mutant AR protein and ameliorates phenotypes of the SBMA transgenic mouse model2021
- Author(s)
  Hiroaki Adachi, Zhe Huang, Kazumasa Okada, Keiko Ohnari, Tomoyo Hashimoto, Tomoko Toyota, Yukio Iwanaka
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Effects of the overexpression of TFEB in cellular and mouse models of spinal and bulbar muscular atrophy2020
- Author(s)
  Hiroaki Adachi, Zhe Huang, Qiang Qiang, Kazumasa Okada, Keiko Ohnari, Tomoyo Hashimoto, Tomoko Toyota, Yukio Iwanaka
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Effects of the overexpression of TFEB in cellullar and mouse models of neurodegenerarive diseases.2020
- Author(s)
  Hiroaki Adachi, Zhe Huang, Qiang Qiang, Kazumasa Okada, Keiko Ohnari, Tomoyo Hashimoto, Tomoko Toyota, Yukio Iwanaka
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Perampanel administration to the Q129 and Q113 DRPLA transgenic mice.2019
- Author(s)
  Toyota T, Huang Z, Okada K, Sato T, Tsuji S, Adachi H.
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Dynactin-1 and TRAPPC9 implicates autophagosome-lysosome fusion defects in the pathogenesis of neurodegenerative diseases.2019
- Author(s)
  Hiroaki Adachi, Zhe Huang, Kazumasa Okada, Keiko Ohnari, Tomoyo Hashimoto, Tomoko Toyota
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Dynactin-1 implicates autophagosome-lysosome fusion defects in the neurodegenerative diseases.2019
- Author(s)
  足立弘明, 黄哲, 岡田和将, 大成圭子, 橋本智代, 豊田知子, 岩中行己男
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07970
[Presentation] Dynactin-1 and TRAPPC9 implicate autophagosome-lysosome fusion in the pathogenesis of neurodegenerative diseases.2019
- Author(s)
  Adachi H, Huang Z, Okada K, Ohnari K, Hashimoto T, Toyota T, Iwanaka Y.
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07970

1. Adachi Hiroaki (40432257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. 黄哲 (30745112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. KINO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 水口剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 宮武聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toyota Tomoko 豊田 知子

Research Projects

Research Products

Co-Researchers

Reducing toxicity of disease-causative molecules with the aim of developing therapies for neurodegenerative diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The development of disease- modifying therapies for progressive myoclonus epilepsyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Reducing toxicity of disease-causative molecules with the aim of developing therapies for neurodegenarative diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer’s disease.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer’s disease.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complete SAMD12 repeat expansion sequencing in a four-generation BAFME1 family with anticipation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 良性成人型家族性ミオクローヌスてんかんの臨床所見及び脳波所見の特徴2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] CSF GAP-43 as a biomarker of synaptic dysfunction is associated with tau pathology in Alzheimer’s disease.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Complete sequencing of expanded SAMD12 repeats by long-read sequencing with Cas9-mediated enrichment.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detecting a long insertion variant in SAMD12 by SMRT sequencing: implications of long-read whole-genome sequencing for repeat expansion diseases2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Kaempferol promotes the degradation of mutant proteins via a novel mTOR-dependent autophagic pathway2023

Author(s)

Organizer

Data Source

[Presentation] 神経変性疾患の病因蛋白質の分解亢進による予防2023

Author(s)

Organizer

Data Source

[Presentation] Kaempferol promotes the degradation of mutant proteins via a novel mTOR-dependent autophagic pathway2023

Toyota Tomoko 豊田知子