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SEN Toun  戦 冬雲

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ZHAN DONGYUN  戦 冬雲

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Researcher Number 30616941
Affiliation (based on the past Project Information) *help 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 派遣研究員
2015: 独立行政法人国立循環器病研究センター, その他部局等, 研究員
2013 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
Review Section/Research Field
Principal Investigator
General pharmacology
Except Principal Investigator
Cardiovascular medicine
Keywords
Principal Investigator
生理活性物質 / 分子心臓学 / 心拍変動 / 心臓自律神経活動 / 生理活性ペプチド / ノックインマウス / 拡張型心筋症
Except Principal Investigator
放射光X線回折法 / 心筋拡張機能障害 / 放射光X線回折法 … More / 心筋収縮タンパク質 / 心臓拡張機能障害 / 糖尿病 / 循環器・高血圧 Less
  • Research Projects

    (3 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (8 People)
  •  Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model rat

    • Principal Investigator
      SHIRAI Mikiyasu
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  拡張型心筋症における心臓迷走神経調節機構異常の解明Principal Investigator

    • Principal Investigator
      戦 冬雲
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  The treatment benefit of ghrelin on a mouse model of inherited dilated cardiomyopathy caused by troponin mutationPrincipal Investigator

    • Principal Investigator
      ZHAN DONGYUN
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      National Cardiovascular Center Research Institute

All 2017 2016 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion.2017

    • Author(s)
      Du CK, Zhan DY, Akiyama T, Inagaki T, Shishido T, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 312(1) Issue: 1 Pages: H60-H67

    • DOI

      10.1152/ajpheart.00471.2016

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26462774, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-16K15452
  • [Journal Article] Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation.2017

    • Author(s)
      Zhan DY, Du CK, Akiyama T, Morimoto S, Shimizu S, Kawada T, Shirai M, Pearson JT.
    • Journal Title

      Auton Neurosci.

      Volume: 205 Pages: 33-40

    • DOI

      10.1016/j.autneu.2017.03.002

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-17K11604, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-15K09110, KAKENHI-PROJECT-16K15452
  • [Journal Article] Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model.2017

    • Author(s)
      Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.
    • Journal Title

      Sci Rep

      Volume: Dec 22;7(1) Issue: 1 Pages: 18108-18108

    • DOI

      10.1038/s41598-017-18485-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16033, KAKENHI-INTERNATIONAL-15K21716, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-17H02100, KAKENHI-PROJECT-16K15452
  • [Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016

    • Author(s)
      Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 311(2) Issue: 2 Pages: 426-439

    • DOI

      10.1152/ajpregu.00112.2016

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K15452, KAKENHI-PROJECT-15K21692
  • [Journal Article] In vivo effects of propyl gallate, a novel Ca(2+) sensitizer, in a mouse model of dilated cardiomyopathy caused by cardiac troponin T mutation.2014

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto
    • Journal Title

      Life Sciences

      Volume: 109 Issue: 1 Pages: 15-19

    • DOI

      10.1016/j.lfs.2014.06.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24790791, KAKENHI-PROJECT-25871236
  • [Journal Article] Myocardial interstitial levels of serotonin and its major metabolite, 5-hydroxyindole acetic acid, in in vivo rat heart2014

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Takashi Sonobe, Tadakatsu Inagaki, Mikiyasu Shirai
    • Journal Title

      Life Sciences

      Volume: 117 Issue: 1 Pages: 33-39

    • DOI

      10.1016/j.lfs.2014.09.019

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24790791, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-25871236, KAKENHI-PROJECT-26462774
  • [Journal Article] Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy2014

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Sachio Morimoto, Tsuyoshi Akiyama, Daryl O. Schwenke, Hiroshi Hosoda, Kenji Kangawa, Mikiyasu Shirai
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 2 Issue: 5

    • DOI

      10.1002/prp2.64

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24790791, KAKENHI-PROJECT-25871236, KAKENHI-PROJECT-26462774
  • [Journal Article] Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats2014

    • Author(s)
      Takashi Sonobe, Akiyama Tsuyoshi, Cheng-Kun Du, Dong-Yun Zhan, Mikiyasu Shirai
    • Journal Title

      Acta Physiologica

      Volume: 210(4) Pages: 823-831

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Journal Article] Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischaemiareperfusion in rabbits2013

    • Author(s)
      Takashi Sonobe, Akiyama Tsuyoshi, Cheng-Kun Du, Dong-Yun Zhan, Mikiyasu Shirai
    • Journal Title

      Acta Physiologica

      Volume: 207 Pages: 260-268

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice2013

    • Author(s)
      Dong-Yun Zhan, Cheng-Kun Du, Akiyama Tsuyoshi, Takashi Sonobe, Hirotsugu Tsuchimochi, Shuji Shimizu, Toru Kawada, Mikiyasu Shirai
    • Journal Title

      Autonomic Neuroscience: Basic and Clinical

      Volume: 176(1-2) Pages: 91-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓交感神経終末ノルエピネフリン動態異常2017

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、白井 幹康、James T. Pearson
    • Organizer
      第94回日本生理学会大会(浜松)
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet2017

    • Author(s)
      H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
    • Organizer
      ESC Congress 2017(Barcelona)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 拡張型心筋症ノックインマウスにおける心臓ノルエピネフリン動態異常2017

    • Author(s)
      戦冬雲、杜成坤、秋山剛、森本幸生、白井幹康、ピアソン ジェームズ
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] 張型心筋症ノックインマウスに対するドネペジルの治療効果2017

    • Author(s)
      杜成坤、戦冬雲、森本幸生、秋山剛、白井幹康、ピアソン ジェームズ
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Data Source
      KAKENHI-PROJECT-16K15452
  • [Presentation] DCMノックインマウスにおける心臓迷走神経調節機構2014

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、清水 秀二、川田 徹、白井 幹康
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] DCMノックインマウスにおける心臓迷走神経調節機構2014

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、森本 幸生、清水 秀二、川田 徹、白井 幹康
    • Organizer
      第87回日本薬理学会大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 4-HBを用いた心筋虚血再灌流のヒドロキシラジカル測定2014

    • Author(s)
      稲垣 薫克、秋山 剛、、戦 冬雲、杜 成坤、白井 幹康
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 虚血/再灌流における心筋間質セロトニンの動態2014

    • Author(s)
      杜 成坤、戦 冬雲、秋山 剛、稲垣 薫克、白井 幹康
    • Organizer
      第87回日本薬理学会大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 虚血/再灌流における心筋間質セロトニンの動態2014

    • Author(s)
      杜 成坤、戦 冬雲、秋山 剛、稲垣 薫克、白井 幹康
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] うっ血性心不全の病態生理学における脳セロトニン機能障害の役割2013

    • Author(s)
      李 蕾、森本 幸生、武 幸子、戦 冬雲、杜 成坤、王 媛媛、範 雪麗、吉原 達也、高橋 富美、片渕 俊彦、笹栗 俊之
    • Organizer
      第17回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 拡張型心筋症ノックインマウスに対するグレリンの治療効果2013

    • Author(s)
      杜 成坤、戦 冬雲、森本 幸生、秋山 剛、寒川 賢治、白井 幹康
    • Organizer
      第17回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] Knock-in mouse model of hypertrophic cardiomyopathy caused by troponin T mutation.

    • Author(s)
      Du Chengkun, Zhan Dongyun, Morimoto Sachio, Shirai Mikiyasu.
    • Organizer
      The 92th annual meeting of the physiological society of Japan
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 心筋トロポニンT突然変異による肥大型心筋症ノックインマウスモデル

    • Author(s)
      杜 成坤、 戦 冬雲、森本 幸生、白井 幹康
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] Survival benefit of ghrelin in the heart failure due to dilated cardiomyopathy.

    • Author(s)
      Zhan Dongyun, Du Chengkun, Morimoto Sachio, Akiyama Tsuyoshi , Schwenke Daryl, Hosoda Hiroshi, Kangawa Kenji, Shirai Mikiyasu.
    • Organizer
      The 92th annual meeting of the physiological society of Japan
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] 中枢を介した迷走神経活性化による拡張型心筋症治療薬

    • Author(s)
      戦 冬雲、杜 成坤、秋山 剛、白井 幹康
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] Role of monoamine oxidase on hydroxyl radical production during ischemia/reperfusion in anesthetized rats.

    • Author(s)
      Inagaki Tadakatsu, Akiyama Tsuyoshi, Zhan Dongyun, Du Chengkun, Shirai Mikiyasu.
    • Organizer
      The 92th annual meeting of the physiological society of Japan
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] The treatment benefit of ghrelin on a mouse model of inherited dilated cardiomyopathy caused by troponin mutation.

    • Author(s)
      Dong-Yun Zhan, Cheng-Kun Du, Sachio Morimoto, Tsuyoshi Akiyama, Daryl O. Schwenke, Hiroshi Hosoda, Kenji Kangawa Mikiyasu Shirai.
    • Organizer
      Biophysical society 59th annual meeting
    • Place of Presentation
      Baltimore, Maryland, USA
    • Year and Date
      2015-02-07 – 2015-02-11
    • Data Source
      KAKENHI-PROJECT-25871236
  • [Presentation] Myocardial interstitial serotonin and its major metabolite, 5-hydroxyindole acetic acid levels determined by microdialysis technique in in vivo rat heart.

    • Author(s)
      Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Takashi Sonobe, Tadakatsu Inagaki, Mikiyasu Shirai.
    • Organizer
      Biophysical society 59th annual meeting
    • Place of Presentation
      Baltimore, Maryland, USA
    • Year and Date
      2015-02-07 – 2015-02-11
    • Data Source
      KAKENHI-PROJECT-25871236
  • 1.  SHIRAI Mikiyasu (70162758)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 2.  TO Seikon (90590646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 3.  KIN Mika (40746773)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  INAGAKI Tadakatsu (20638366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  土持 裕胤 (60379948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  Pearson James (30261390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  YAGI Naoto
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  森本 幸生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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