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Kenzo Yamatsugu  山次 健三

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… Alternative Names

Yamatsugu Kenzo  山次 健三

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Researcher Number 30646807
Other IDs
Affiliation (Current) 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help 2016 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
2015: 東京大学, 薬学研究科(研究院), 助教
2014: 東京大学, 薬学研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Transformative Research Areas, Section (II) / Drug development chemistry / Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields
Except Principal Investigator
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords
Principal Investigator
触媒 / タンパク質 / アシル化 / ヒストン / 細胞内反応 / 翻訳後修飾 / in-cell reaction / subcellular localization / protein / catalyst … More / acylation / 細胞内局在 / タンパク質化学修飾 / リン酸化 / 水酸基 / ホスホエノールピルビン酸 / ホスホエノールビルビン酸 / ブレンステッド酸 / 求核触媒 / ATP / 薬学 / 有機化学 / エピジェネティクス / リジン / 分子夾雑 / 細胞 / 化学合成 / ペプチド / ピリジン / 環境 / 細胞内化学 / 人工修飾 / 環境応答 / 化学修飾 … More
Except Principal Investigator
DNA修復 / エピゲノム修飾 / ヒストンアシル化 / アシル化触媒 / 触媒 / ヒストン / 染色体 / アシル化 Less
  • Research Projects

    (9 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (10 People)
  •  In-cell chemical network driven by neo-PTMsArea Organizer

    • Area Organizer
      山次 健三
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
  •  neo-PTMs: Cellular chemical networks created by non-canonical post-translational modificationsPrincipal Investigator

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Tokyo
  •  Chemical catalyst-driven neo-PTMs in cellsPrincipal Investigator

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Transformative Research Areas (B)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Tokyo
  •  酵素には不可能なヒストン超アシル化による生細胞エピゲノム操作と理解Principal Investigator

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      The University of Tokyo
  •  化学触媒ツールの開発を基軸としたヒストン修飾とDNA修復の相関解明

    • Principal Investigator
      金井 求
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      The University of Tokyo
  •  タンパク質化学合成を革新するペプチド連結触媒の開発Principal Investigator

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      The University of Tokyo
  •  分子夾雑下ヒストンアシル化による細胞機能制御を可能にする化学触媒システムの開発Principal Investigator

    • Principal Investigator
      山次 健三
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Direct, catalytic , and site-selective phosphorylation of hydroxy group using molecular recognition and dynamic covalent bondingPrincipal Investigator

    • Principal Investigator
      Yamatsugu Kenzo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokyo
  •  Regulation of subcellular localization and functions of proteins by in-cell catalytic reactionsPrincipal Investigator

    • Principal Investigator
      Yamatsugu Kenzo
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo

All 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] A Stable and Cleavable <i>O</i>-Linked Spacer for Drug Delivery Systems2020

    • Author(s)
      Ito Kei、Tatsumi Toshifumi、Takahashi Kazuki、Shimizu Yohei、Yamatsugu Kenzo、Kanai Motomu
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 3 Pages: 212-215

    • DOI

      10.1248/cpb.c19-00376

    • NAID

      130007804083

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14207, KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-20H00489
  • [Journal Article] Hydroxamic Acid‐Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions2020

    • Author(s)
      Mizumoto Shinsuke、Xi Siqi、Fujiwara Yusuke、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
    • Journal Title

      Chemistry An Asian Journal

      Volume: 15 Pages: 833-839

    • DOI

      10.1002/asia.201901737

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489
  • [Journal Article] Catalytic ChemoselectiveO-Phosphorylation of Alcohols2020

    • Author(s)
      Domon K.、Puripat M.、Fujiyoshi K.、Hatanaka M.、Kawashima S. A.、Yamatsugu K.、Kanai M.
    • Journal Title

      ACS Central Science

      Volume: 6 Pages: 283-292

    • DOI

      10.1021/acscentsci.9b01272

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06445, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17K15420, KAKENHI-PROJECT-20H00489
  • [Journal Article] Synthetic hyperacetylation of nucleosomal histones.2020

    • Author(s)
      Kajino Hidetoshi、Nagatani Tomomi、Oi Miku、Kujirai Tomoya、Kurumizaka Hitoshi、Nishiyama Atsuya、Nakanishi Makoto、Yamatsugu Kenzo、Kawashima Shigehiro A.、Kanai Motomu
    • Journal Title

      RSC Chemical Biology

      Volume: 1 Pages: 56-59

    • DOI

      10.1039/d0cb00029a

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-20K21497, KAKENHI-PROJECT-19KK0179, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-18K19138
  • [Journal Article] Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System2019

    • Author(s)
      Hamajima W, Fujimura A, Fujiwara Y, Yamatsugu K, Kawashima SA, Kanai M.
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Pages: 1102-1109

    • DOI

      10.1021/acschembio.9b00102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-17K19479, KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17H01522
  • [Journal Article] Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation catalysts2018

    • Author(s)
      Yamatsugu Kenzo、Furuta Masahiro、Xi Siqi、Amamoto Yoshifumi、Liu Jiaan、Kawashima Shigehiro A.、Kanai Motomu
    • Journal Title

      Bioorganic & medicinal chemistry

      Volume: 26 Pages: 5359-5367

    • DOI

      10.1016/j.bmc.2018.07.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-18K14273, KAKENHI-PROJECT-17H01522, KAKENHI-PUBLICLY-18H04536
  • [Presentation] 高い官能基許容性を有する水酸基の触媒的単段階リン酸化反応の開発2019

    • Author(s)
      山次健三、土門憲史、Maneeporn Puripat、畑中美穂、川島茂裕、金井求
    • Organizer
      日本ケミカルバイオロジー 学会第14回年会
    • Data Source
      KAKENHI-PROJECT-17K15420
  • [Presentation] ヒストンに翻訳後修飾を導入する化学触媒2019

    • Author(s)
      山次健三
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H04536
  • [Presentation] 触媒的無保護リン酸エステル化反応の開発2018

    • Author(s)
      土門憲史、山次健三、金井求
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K15420
  • [Presentation] 新規疾病治療法の確立を目標とした触媒的化学修飾による標的タンパク質の細胞内局在制御法の開発研究2017

    • Author(s)
      濱島航、石黒伸茂、川島茂裕、山次健三、金井求
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(宮城県、仙台)
    • Data Source
      KAKENHI-PROJECT-26460142
  • [Presentation] ヒストンアセチル化人工触媒の開発と触媒医療への取り組み2017

    • Author(s)
      山次健三
    • Organizer
      富士フイルム
    • Place of Presentation
      富士フイルム先進研究所(神奈川県、足柄上郡)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460142
  • [Presentation] 触媒医療の実現に向けて: 人工触媒システムによる ヒストンの合成的アシル化(2)2017

    • Author(s)
      山次健三、川島茂裕
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学(宮城県、仙台)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460142
  • 1.  金井 求 (20243264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 2.  川島 茂裕 (40508115)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  藤村 亜紀子 (80793091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  五月女 宜裕 (50431888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  島津 忠広 (10618771)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SHIMIZU Yohei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  畑中 美穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  中西 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  藤 泰子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  天本 義史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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