Kenzo Yamatsugu 山次健三

… Alternative Names

Yamatsugu Kenzo 山次健三

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Researcher Number	30646807
Other IDs
Affiliation (Current)	2022: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 助教 2015: 東京大学, 薬学研究科(研究院), 助教 2014: 東京大学, 薬学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (II) / Drug development chemistry / Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Medium-sized Section 47:Pharmaceutical sciences and related fields Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 触媒 / タンパク質 / アシル化 / ヒストン / 細胞内反応 / 翻訳後修飾 / in-cell reaction / subcellular localization / protein / catalyst … More / acylation / 細胞内局在 / タンパク質化学修飾 / リン酸化 / 水酸基 / ホスホエノールピルビン酸 / ホスホエノールビルビン酸 / ブレンステッド酸 / 求核触媒 / ATP / 薬学 / 有機化学 / エピジェネティクス / リジン / 分子夾雑 / 細胞 / 化学合成 / ペプチド / ピリジン / 環境 / 細胞内化学 / 人工修飾 / 環境応答 / 化学修飾 … More Except Principal Investigator DNA修復 / エピゲノム修飾 / ヒストンアシル化 / アシル化触媒 / 触媒 / ヒストン / 染色体 / アシル化 Less

In-cell chemical network driven by neo-PTMsArea Organizer
- Area Organizer
  
  山次健三
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
neo-PTMs: Cellular chemical networks created by non-canonical post-translational modificationsPrincipal Investigator
- Principal Investigator
  
  山次健三
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Chemical catalyst-driven neo-PTMs in cellsPrincipal Investigator
- Principal Investigator
  
  山次健三
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
酵素には不可能なヒストン超アシル化による生細胞エピゲノム操作と理解Principal Investigator
- Principal Investigator
  
  山次健三
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
化学触媒ツールの開発を基軸としたヒストン修飾とDNA修復の相関解明
- Principal Investigator
  
  金井求
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
タンパク質化学合成を革新するペプチド連結触媒の開発Principal Investigator
- Principal Investigator
  
  山次健三
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  The University of Tokyo
分子夾雑下ヒストンアシル化による細胞機能制御を可能にする化学触媒システムの開発Principal Investigator
- Principal Investigator
  
  山次健三
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Direct, catalytic , and site-selective phosphorylation of hydroxy group using molecular recognition and dynamic covalent bondingPrincipal Investigator
- Principal Investigator
  
  Yamatsugu Kenzo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Regulation of subcellular localization and functions of proteins by in-cell catalytic reactionsPrincipal Investigator
- Principal Investigator
  
  Yamatsugu Kenzo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] A Stable and Cleavable <i>O</i>-Linked Spacer for Drug Delivery Systems2020
- Author(s)
  Ito Kei、Tatsumi Toshifumi、Takahashi Kazuki、Shimizu Yohei、Yamatsugu Kenzo、Kanai Motomu
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 68 Issue: 3 Pages: 212-215
- DOI
  10.1248/cpb.c19-00376
- NAID
  130007804083
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14207, KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-20H00489
[Journal Article] Hydroxamic Acid‐Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions2020
- Author(s)
  Mizumoto Shinsuke、Xi Siqi、Fujiwara Yusuke、Kawashima Shigehiro A.、Yamatsugu Kenzo、Kanai Motomu
- Journal Title
  
  Chemistry An Asian Journal
  
  Volume: 15 Pages: 833-839
- DOI
  10.1002/asia.201901737
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-19KK0179, KAKENHI-PROJECT-20H00489
[Journal Article] Catalytic ChemoselectiveO-Phosphorylation of Alcohols2020
- Author(s)
  Domon K.、Puripat M.、Fujiyoshi K.、Hatanaka M.、Kawashima S. A.、Yamatsugu K.、Kanai M.
- Journal Title
  
  ACS Central Science
  
  Volume: 6 Pages: 283-292
- DOI
  10.1021/acscentsci.9b01272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06445, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17K15420, KAKENHI-PROJECT-20H00489
[Journal Article] Synthetic hyperacetylation of nucleosomal histones.2020
- Author(s)
  Kajino Hidetoshi、Nagatani Tomomi、Oi Miku、Kujirai Tomoya、Kurumizaka Hitoshi、Nishiyama Atsuya、Nakanishi Makoto、Yamatsugu Kenzo、Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  RSC Chemical Biology
  
  Volume: 1 Pages: 56-59
- DOI
  10.1039/d0cb00029a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-20K21497, KAKENHI-PROJECT-19KK0179, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-19H05740, KAKENHI-PROJECT-20H00489, KAKENHI-PROJECT-18K19138
[Journal Article] Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System2019
- Author(s)
  Hamajima W, Fujimura A, Fujiwara Y, Yamatsugu K, Kawashima SA, Kanai M.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Pages: 1102-1109
- DOI
  10.1021/acschembio.9b00102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19138, KAKENHI-PROJECT-17K19479, KAKENHI-PUBLICLY-18H04536, KAKENHI-PROJECT-17H01522
[Journal Article] Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation catalysts2018
- Author(s)
  Yamatsugu Kenzo、Furuta Masahiro、Xi Siqi、Amamoto Yoshifumi、Liu Jiaan、Kawashima Shigehiro A.、Kanai Motomu
- Journal Title
  
  Bioorganic & medicinal chemistry
  
  Volume: 26 Pages: 5359-5367
- DOI
  10.1016/j.bmc.2018.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-18K14273, KAKENHI-PROJECT-17H01522, KAKENHI-PUBLICLY-18H04536
[Presentation] 高い官能基許容性を有する水酸基の触媒的単段階リン酸化反応の開発2019
- Author(s)
  山次健三、土門憲史、Maneeporn Puripat、畑中美穂、川島茂裕、金井求
- Organizer
  日本ケミカルバイオロジー学会第１４回年会
- Data Source
  KAKENHI-PROJECT-17K15420
[Presentation] ヒストンに翻訳後修飾を導入する化学触媒2019
- Author(s)
  山次健三
- Organizer
  日本薬学会第１３９年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04536
[Presentation] 触媒的無保護リン酸エステル化反応の開発2018
- Author(s)
  土門憲史、山次健三、金井求
- Organizer
  第４４回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K15420
[Presentation] 新規疾病治療法の確立を目標とした触媒的化学修飾による標的タンパク質の細胞内局在制御法の開発研究2017
- Author(s)
  濱島航、石黒伸茂、川島茂裕、山次健三、金井求
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  東北大学（宮城県、仙台）
- Data Source
  KAKENHI-PROJECT-26460142
[Presentation] ヒストンアセチル化人工触媒の開発と触媒医療への取り組み2017
- Author(s)
  山次健三
- Organizer
  富士フイルム
- Place of Presentation
  富士フイルム先進研究所（神奈川県、足柄上郡）
- Invited
- Data Source
  KAKENHI-PROJECT-26460142
[Presentation] 触媒医療の実現に向けて：人工触媒システムによるヒストンの合成的アシル化（２）2017
- Author(s)
  山次健三、川島茂裕
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  東北大学（宮城県、仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-26460142

1. 金井求 (20243264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 川島茂裕 (40508115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 藤村亜紀子 (80793091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 五月女宜裕 (50431888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 島津忠広 (10618771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMIZU Yohei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 畑中美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中西真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤泰子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 天本義史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kenzo Yamatsugu 山次 健三

Yamatsugu Kenzo 山次 健三

Research Projects

Research Products

Co-Researchers

In-cell chemical network driven by neo-PTMsArea Organizer

Area Organizer

Project Period (FY)

Research Category

neo-PTMs: Cellular chemical networks created by non-canonical post-translational modificationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Chemical catalyst-driven neo-PTMs in cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酵素には不可能なヒストン超アシル化による生細胞エピゲノム操作と理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

化学触媒ツールの開発を基軸としたヒストン修飾とDNA修復の相関解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質化学合成を革新するペプチド連結触媒の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

分子夾雑下ヒストンアシル化による細胞機能制御を可能にする化学触媒システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Direct, catalytic , and site-selective phosphorylation of hydroxy group using molecular recognition and dynamic covalent bondingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of subcellular localization and functions of proteins by in-cell catalytic reactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Stable and Cleavable <i>O</i>-Linked Spacer for Drug Delivery Systems2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Hydroxamic Acid‐Piperidine Conjugate is an Activated Catalyst for Lysine Acetylation under Physiological Conditions2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic ChemoselectiveO-Phosphorylation of Alcohols2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthetic hyperacetylation of nucleosomal histones.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System2019

Kenzo Yamatsugu 山次健三

Yamatsugu Kenzo 山次健三

[Presentation] 触媒医療の実現に向けて：人工触媒システムによるヒストンの合成的アシル化（２）2017