Matsunaga Shinji 松永慎司

Researcher Number	30704910
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪公立大学, 大学院医学研究科, 講師 2017 – 2021: 大阪市立大学, 大学院医学研究科, 講師 2016: 大阪市立大学, 大学院医学研究科, 助教 2015: 鳥取大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Pharmacology in pharmacy Except Principal Investigator General pharmacology
Keywords	Principal Investigator 腫瘍 / 自然免疫 / 低酸素誘導因子 / 腫瘍微小環境 / 腫瘍免疫 / 血管 / 薬物動態 / 血管内皮 / 血管リモデリング / 腫瘍血管 … More / 血管正常化 / 薬理学 / マクロファージ / 血管再構築 … More Except Principal Investigator 癌微小環境 / HIF / PHD阻害剤 / 低酸素 / 腫瘍血管 / 癌治療 / 自然免疫 / PHD阻害薬 / 腫瘍免疫 / がん微小環境 / 血管リモデリング Less

腫瘍組織内自然免疫細胞を利用した治療抵抗性腫瘍に対する治療戦略の開発Principal Investigator
- Principal Investigator
  
  松永慎司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Osaka Metropolitan University
Improve of tumor microenvironment regulate anti-tumor immune responsePrincipal Investigator
- Principal Investigator
  
  Matsunaga Shinji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Basic research of cancer therapy by improving anticancer drug sensitivity through tumor vascular remodeling
- Principal Investigator
  
  Tomita Shuhei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka City University
The effects of PHD inhibitor on tumor blood vessel normalizationPrincipal Investigator
- Principal Investigator
  
  Matsunaga Shinji
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Osaka City University
Tumor blood vessel normalization by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumor mouse model
- Principal Investigator
  
  Tomita Shuhei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka City University
  Tottori University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

[Book] 尿酸と血糖「第5回忙しい人のための抄読会」2016
- Author(s)
  松永慎司，冨田修平
- Total Pages
  4
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-15K15054
[Book] 医学のあゆみ（別冊）レドックスUPDATE「血管リモデリングにおける低酸素応答性転写因子の役割」2015
- Author(s)
  冨田修平, 松永慎司
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K15054
[Journal Article] Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model2020
- Author(s)
  Kabei Kazuya、Tateishi Yu、Shiota Masayuki、Osada-Oka Mayuko、Nishide Shunji、Uchida Junji、Nakatani Tatsuya、Matsunaga Shinji、Yamaguchi Takehiro、Tomita Shuhei、Miura Katsuyuki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 142 Issue: 3 Pages: 93-100
- DOI
  10.1016/j.jphs.2019.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07943, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-17K08836, KAKENHI-PROJECT-17K08958, KAKENHI-PROJECT-20K07072, KAKENHI-PROJECT-17K08602
[Journal Article] The effect of PHD inhibitor on tumor microenvironment and tumor immune response2020
- Author(s)
  Matsunaga S, Tomita S.
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 155 Issue: 1 Pages: 35-39
- DOI
  10.1254/fpj.19119
- NAID
  130007778893
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17K08602
[Journal Article] Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice2020
- Author(s)
  Nishide Shunji、Uchida Junji、Matsunaga Shinji、Tokudome Kentaro、Yamaguchi Takehiro、Kabei Kazuya、Moriya Taiki、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 2 Pages: 122-126
- DOI
  10.1016/j.jphs.2020.02.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14598, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-19K18594, KAKENHI-PROJECT-17K08958, KAKENHI-PROJECT-20K07072, KAKENHI-PROJECT-17K08602
[Journal Article] A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-42019
- Author(s)
  Yamaguchi Takehiro、Watanabe Ayano、Tanaka Masako、Shiota Masayuki、Osada-Oka Mayuko、Sano Soichi、Yoshiyama Minoru、Miura Katsuyuki、Kitajima Shojiro、Matsunaga Shinji、Tomita Shuhei、Iwao Hiroshi、Izumi Yasukatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 139 Issue: 2 Pages: 112-119
- DOI
  10.1016/j.jphs.2018.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08602, KAKENHI-PROJECT-17K08958, KAKENHI-PROJECT-17K15757, KAKENHI-PROJECT-15K08649
[Journal Article] Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model2019
- Author(s)
  Nishide Shunji、Matsunaga Shinji、Shiota Masayuki、Yamaguchi Takehiro、Kitajima Shojiro、Maekawa Yoichi、Takeda Norihiko、Tomura Michio、Uchida Junji、Miura Katsuyuki、Nakatani Tatsuya、Tomita Shuhei
- Journal Title
  
  iScience
  
  Volume: 21 Pages: 205-205
- DOI
  10.1016/j.isci.2019.10.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21582, KAKENHI-PROJECT-17K08602
[Journal Article] Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model.2017
- Author(s)
  Koyama S, Matsunaga S, Imanishi M, Maekawa Y, Kitano H, Takeuchi H, Tomita S
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 45621-45621
- DOI
  10.1038/srep45621
- NAID
  120006535012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15054, KAKENHI-PROJECT-17K08602, KAKENHI-PROJECT-16K15524, KAKENHI-PROJECT-15H04724
[Journal Article] Hypoxia-inducible factor-1α in smooth muscle cells protects against aortic aneurysms.2016
- Author(s)
  Imanishi M, Chiba Y, Tomita N, Matsunaga S, Nakagawa T, Ueno M, Yamamoto K, Tamaki T, Tomita S
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 36 Issue: 11 Pages: 2158-2162
- DOI
  10.1161/atvbaha.116.307784
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15054
[Patent] 腫瘍関連マクロファージ賦活化剤2019
- Inventor(s)
  冨田修平・松永慎司・西出峻治・内田潤次
- Industrial Property Rights Holder
  冨田修平・松永慎司・西出峻治・内田潤次
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-143014
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K08602
[Patent] 抗癌剤の抗腫瘍効果の増強剤、癌治療剤、及び癌治療用医薬組成物2016
- Inventor(s)
  冨田修平・松永慎司
- Industrial Property Rights Holder
  冨田修平・松永慎司
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-171299
- Filing Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K15054
[Presentation] 腫瘍関連マクロファージにおける低酸素誘導因子発現上昇が腫瘍に与える影響2023
- Author(s)
  松永慎司、本間拓二郎、平川遼、冨田修平
- Organizer
  低酸素研究会　2023年学術集会
- Data Source
  KAKENHI-PROJECT-23K06154
[Presentation] マクロファージの低酸素誘導因子が腫瘍進展に与える影響の検討2023
- Author(s)
  松永慎司、本間拓二郎、平川遼、冨田修平
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K06154
[Presentation] 腫瘍増殖に対する腫瘍浸潤マクロファージの低酸素誘導因子の影響2022
- Author(s)
  松永慎司、山口一行、平川遼、徳留健太郎、山口雄大、冨田修平
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07295
[Presentation] PHD阻害薬によるがん微小環境と腫瘍免疫への影響2022
- Author(s)
  松永慎司
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07295
[Presentation] 担癌モデルマウスにおけるプロリン水酸化阻害剤の腫瘍組織に対する効果検討2021
- Author(s)
  松永慎司、山口一行、平川遼、徳留健太郎、山口雄大、冨田修平
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07295
[Presentation] 胎児期低酸素ストレス負荷による自閉症様症状の発現には抑制性シナプス関連遺伝子の発現低下が関与する2020
- Author(s)
  徳留健太郎、松永慎司、山口雄大、冨田修平
- Organizer
  第93回日本薬理学会
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] Alteration the phenotype of tumor-infiltrating macrophages via the PHD-HIF axis inhibits tumor growth in mice.2020
- Author(s)
  Shunji Nishide, Shinji Matsunaga, Takehiro Yamaguchi, Norihiko Takeda, Junji Uchida, Katsuyuki Miura, Tatsuya Nakatani and Shuhei Tomita
- Organizer
  Keystone Symposia -Hypoxia: Molecules, Mechanisms and Disease-
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] リナグリプチンは心筋梗塞後のDPP-4非依存的に左室リモデリングを抑制する2020
- Author(s)
  山口雄大、泉康雄、塩田正之、松永慎司、德留健太郎、三浦克之、岩尾洋、冨田修平
- Organizer
  第93回日本薬理学会
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] PHD阻害剤による腫瘍浸潤マクロファージの表現型変化は腫瘍環境改善を誘導する2020
- Author(s)
  松永慎司、西出峻治、徳留健太郎、山口雄大、冨田修平
- Organizer
  第93回日本薬理学会
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] PHD阻害薬によるがん微小環境と腫瘍免疫への影響2019
- Author(s)
  松永慎司、冨田修平
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K15459
[Presentation] Improvement of tumor microenvironment induce macrophage activation in tumor bearing mouse.2019
- Author(s)
  Shinji Matsunaga, Shunji Nishide, Masayuki Shiota, Takehiro Yamaghchi, Katsuyuki Miura, Shuhei Tomita
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K15459
[Presentation] Hypoxia-inducible factor-1α regulates energy fuel metabolism and mediates metabolic plasticity during ammonia stress response in ovarian cancer stem-like cells.2018
- Author(s)
  Shojiro Kitajima, Kian Leong Lee, Hiroki Hikasa, Shinji Matsunaga, Takehiro Yamaguchi, Shuhei Tomita, Marito Araki, Hiroyuki Kato and Lorenz Poellinger
- Organizer
  18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] Dipeptidyl Peptidase-4 (DPP-4) inhibition Attenuates Cardiac Dysfunction after Myocardial Infarction Independently of DPP-4.2018
- Author(s)
  Yamaguchi T, Izumi Y, Shiota M, Tanaka M, Osada-Oka M, Matsunaga S, Kitajima S, Miura K, Iwao H, Tomita S
- Organizer
  18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] Prolyl Hydroxylase inhibitor repaired chemo-sensitivity through tumor blood vessel normalization in tumor mouse model.2018
- Author(s)
  Shinji Matsunaga, Shunji Nishide, Masayuki Shiota, Takehiro Yamaghchi, Shojiro Kitajima, Katsuyuki Miura and Shuhei Tomita.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology, July 1-6, Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] Prolyl Hydroxylase inhibitor repaired chemo-sensitivity through tumor blood vessel normalization in tumor mouse model.2018
- Author(s)
  Shinji Matsunaga, Shunji Nishide, Masayuki Shiota, Takehiro Yamaghchi, Shojiro Kitajima, Katsuyuki Miura, Shuhei Tomita.
- Organizer
  第91回日本薬理学会年会・第18回国際薬理学・臨床薬理会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15459
[Presentation] 肺血管内皮細胞由来低酸素応答因子 HIF が肺高血圧症の病態形成に果たす役割2018
- Author(s)
  冨田修平，山口雄大，松永慎司
- Organizer
  第47回日本心脈管作動物質学会年会
- Data Source
  KAKENHI-PROJECT-17K08602
[Presentation] 薬剤誘導性腫瘍血管正常化は抗癌剤感受性を増強させる2018
- Author(s)
  松永慎司、西出峻治、北島正二朗、山口雄大、塩田正之、三浦克之、冨田修平
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K15459
[Presentation] Normalization of tumor blood vessel induced by neovascularization drug.2016
- Author(s)
  松永慎司、小山哲史、井口道代、今西正樹、冨田修平
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜（横浜パシフィコ）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K15054
[Presentation] The effect of antioxidants treatment on Seminal Vesicles and Vas Deferens function in the Diabetes Mellitus rat model.2015
- Author(s)
  Panagiota Tsounapi, Masashi Honda, Shinji Hirano, Bunya Kawamoto, Katsuya Hikita, Kuniyasu Muraoka, Michiyo Iguchi, Masaki Imanishi, Shinji Matsunaga, Shuhei Tomita, Takehiro Sejima, Atsushi Takenaka.
- Organizer
  The 103rd Annual Meeting of the Japanese Urological Association
- Place of Presentation
  Kanazawa(Kanazawa Art Hall（石川県金沢市）)
- Year and Date
  2015-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15054

1. Tomita Shuhei (00263898)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. SHIOTA masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NISHIDE shunji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. MORIYA Taiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 富田修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 16 results
6. 前川洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山口雄大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsunaga Shinji 松永 慎司

Research Projects

Research Products

Co-Researchers

腫瘍組織内自然免疫細胞を利用した治療抵抗性腫瘍に対する治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improve of tumor microenvironment regulate anti-tumor immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research of cancer therapy by improving anticancer drug sensitivity through tumor vascular remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of PHD inhibitor on tumor blood vessel normalizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tumor blood vessel normalization by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumor mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 尿酸と血糖「第5回忙しい人のための抄読会」2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 医学のあゆみ（別冊）レドックスUPDATE「血管リモデリングにおける低酸素応答性転写因子の役割」2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of PHD inhibitor on tumor microenvironment and tumor immune response2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-42019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Hypoxia-inducible factor-1α in smooth muscle cells protects against aortic aneurysms.2016

Author(s)

Matsunaga Shinji 松永慎司

[Presentation] Hypoxia-inducible factor-1α regulates energy fuel metabolism and mediates metabolic plasticity during ammonia stress response in ovarian cancer stem-like cells.2018