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Sasahara Tomoya  笹原 智也

ORCIDConnect your ORCID iD *help
Researcher Number 30735345
Other IDs
Affiliation (Current) 2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス)
Affiliation (based on the past Project Information) *help 2021 – 2023: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス)
2018 – 2020: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(研究員・PDクラス)
2016 – 2017: 公益財団法人先端医療振興財団, その他部局等, 研究員(研究員・PDクラス)
Review Section/Research Field
Principal Investigator
Basic Section 47040:Pharmacology-related / General pharmacology
Except Principal Investigator
Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry
Keywords
Principal Investigator
脳血管アミロイド血症 / 血管機能障害 / アミロスフェロイド / 血管内皮 / アルツハイマー病 / δ-セクレターゼ / β-セクレターゼ / アミロイドβ / アミロイドβタンパク / Neuro-vascular Unit … More / Na+ポンプ / 血管周皮細胞(ペリサイト) / Neurovascular unit / 生理学 / 薬理学 / Na+/K+-ATPase / Na+/K+-ATPase alpha 3 / 脳アミロイド血管症 / 一酸化窒素 / eNOS … More
Except Principal Investigator
異常凝集体 / アルツハイマー病 / 神経細胞死 / 神経変性疾患 / ペプチド創薬 / タンパク質ータンパク質相互作用 / ナトリウムポンプ / 治療法 / 診断方法 / コンパニオン診断薬 / 脳神経疾患 Less
  • Research Projects

    (6 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (10 People)
  •  アルツハイマー病脳血管障害が神経機能を悪化させる作用機序の解明Principal Investigator

    • Principal Investigator
      笹原 智也
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発

    • Principal Investigator
      星 美奈子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  Investigation of the mechanism worsening Alzheimer's disease by vascular endothelial dysfunction in cerebral amyloid angiopathy.Principal Investigator

    • Principal Investigator
      Sasahara Tomoya
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  Elucidation of pathogenesis of Alzheimer's disease by the development of diagnostic methods for abnormal aggregates

    • Principal Investigator
      HOSHI Minako
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates

    • Principal Investigator
      HOSHI Minako
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  The activity of endothelial NO synthase is suppressed by amylospheroidPrincipal Investigator

    • Principal Investigator
      Sasahara Tomoya
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Foundation for Biomedical Research and Innovation

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells2021

    • Author(s)
      Sasahara Tomoya、Satomura Kaori、Tada Mari、Kakita Akiyoshi、Hoshi Minako
    • Journal Title

      iScience

      Volume: 24 Issue: 9 Pages: 102936-102936

    • DOI

      10.1016/j.isci.2021.102936

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K16022, KAKENHI-PROJECT-20H03457
  • [Journal Article] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2021

    • Author(s)
      Sasahara T, Hoshi M
    • Journal Title

      STAR Protocol

      Volume: 3(1) Issue: 1 Pages: 101053-101053

    • DOI

      10.1016/j.xpro.2021.101053

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16022, KAKENHI-PROJECT-20H03457, KAKENHI-PROJECT-22K18380
  • [Journal Article] NMR-based site-resolved profiling of ホイ-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.2020

    • Author(s)
      Yiling Xiao, Isamu Matsuda, Masafumi Inoue, Tomoya Sasahara, Minako Hoshi, Yoshitaka Ishii
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 295 Issue: 2 Pages: 458-467

    • DOI

      10.1074/jbc.ra119.008522

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04055, KAKENHI-PROJECT-15K21772, KAKENHI-PROJECT-20H03457
  • [Journal Article] Alzheimer Abeta Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK3 Neurons by Secretion2019

    • Author(s)
      Komura, H., Kakio, S., Sasahara, T., Arai, Y., Takino, N., Sato, M., Satomura, K., Ohnishi, T., Nabesima, Y., Muramatsu, S., Kii, I., and Hoshi, M.
    • Journal Title

      iScience

      Volume: 13 Pages: 452-477

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04055
  • [Presentation] Interaction of Alzheimer patients’ amyloid β oligomer with Na+, K+-ATPase α3 in brain pericytes induces activation of δ-secretase in cortical neurons2023

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第97回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-22K06643
  • [Presentation] 「アルツハイマー病由来アミロイドβ凝集体は脳周皮細胞の機能障害を介して神経細胞のδ-secretaseを活性化する: 周皮細胞におけるアミロイドβ凝集体の結合ターゲットの探索」2023

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      日本薬理学会第97年会 (日本薬理学会主催)、
    • Data Source
      KAKENHI-PROJECT-22K18380
  • [Presentation] The damage of vascular cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases the expression of BACE protein through endothelial cells-derived angiotensin II release.2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-22K18380
  • [Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会 合同学術会議
    • Data Source
      KAKENHI-PROJECT-20H03457
  • [Presentation] アルツハイマー病アミロイドβ凝集体“アミロスフェロイド”による血管内皮細胞障害はアンジオテンシンIIの遊離を介して神経細胞のBACE発現量を増加する2022

    • Author(s)
      笹原 智也、星美奈子
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20H03457
  • [Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K16022
  • [Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会 合同学術会議
    • Data Source
      KAKENHI-PROJECT-22K18380
  • [Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第96回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-22K06643
  • [Presentation] The damage of vascular cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases the expression of BACE protein through endothelial cells-derived angiotensin II release.2022

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20H03457
  • [Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2021

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K16022
  • [Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2021

    • Author(s)
      笹原智也、星美奈子
    • Organizer
      第94回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20H03457
  • [Presentation] Highly neurotoxic amyloid-ホイ assemblies from Alzheimer's disease brain, amylospheroids, inhibit endothelial NAKホア3 activity, resulting in the inhibition of eNOS activity in human brain microvascular endothelial cells2020

    • Author(s)
      笹原 智也
    • Organizer
      第93回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-17H04055
  • [Presentation] アルツハイマー病患者脳由来アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮のNa+, K+-ATPase α3を介してeNOSを不活性化する(Highly neurotoxic amyloid-β assemblies from Alzheimer's disease brain, amylospheroids, inhibit endothelial NAKα3 activity, resulting in the inhibition of eNOS activity in human brain microvascular endothelial cells)2020

    • Author(s)
      笹原 智也、里村香織、他田真理、柿田明美、星美奈子
    • Organizer
      第93回日本薬理学会年会(神奈川)
    • Data Source
      KAKENHI-PROJECT-20H03457
  • [Presentation] Toxic amyloid-β assemblies, amylospheroids, inactivate eNOS through a NAKα3-mediated ROS/PKC pathway in human brain microvascular endothelial cells.2018

    • Author(s)
      笹原智也、里村香織、星美奈子
    • Organizer
      第91回日本薬理学会年会 (第18回国際薬理・臨床薬理学会議と合同開催)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21713
  • [Presentation] Toxic amyloid-beta assemblies, amylospheroids, inactivate eNOS through NAK alpha3-mediated mitochondrial ROS production in human brain microvascular endothelial cells2018

    • Author(s)
      Sasahara, T., Satomura, K., Kakita, A., Hoshi, M.
    • Organizer
      Gordon Research Conference / Neurobiology of Brain Disorders
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04055
  • [Presentation] Toxic amyloid-β assemblies, amylospheroids, inactivate eNOS through a NAKα-mediated ROS/PKC pathway in human brain microvascular endothelial cells2018

    • Author(s)
      笹原智也、里村香織、星美奈子
    • Organizer
      「日本薬理学会」「国際薬理・臨床薬理学会」合同大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04055
  • [Presentation] アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮においてNAKa3を介したPKC活性化によりeNOS活性を低下する(Toxic amyloid-β assemblies, amylospheroids, inhibit eNOS activity through NAKα3-mediated PKC activation in human brain microvascular endothelial cells)2017

    • Author(s)
      笹原智也、里村香織、星美奈子
    • Organizer
      第90回日本薬理学会年会(主催 日本薬理学会)
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-16K21713
  • [Presentation] アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮において NAKa3を介したPKC活性化によりeNOS活性を低下する(Toxic amyloid-β assemblies, amylospheroids, inhibit eNOS activity through NAKα3-mediated PKC activation in human brain microvascular endothelial cells)2017

    • Author(s)
      笹原智也、里村香織、星美奈子
    • Organizer
      第90回日本薬理学会年会(主催 日本薬理学会)
    • Data Source
      KAKENHI-PROJECT-16K21713
  • 1.  HOSHI Minako (30374010)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 2.  久保 厚子 (70647792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  村松 慎一 (10239543)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  豊島 近 (70172210)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  廣明 秀一 (10336589)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  垣尾 翔大 (10789085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  石井 佳誉 (40799045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  喜井 勲 (80401561)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  柿田 明美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  他田 真理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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