Sasahara Tomoya 笹原智也

Researcher Number	30735345
Other IDs
Affiliation (Current)	2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2025: 京都大学, 医学研究科, 特定研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2021 – 2023: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2018 – 2020: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(研究員・PDクラス) 2016 – 2017: 公益財団法人先端医療振興財団, その他部局等, 研究員(研究員・PDクラス)
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / General pharmacology Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Pathological medical chemistry
Keywords	Principal Investigator 脳血管アミロイド血症 / 血管機能障害 / アミロスフェロイド / 血管内皮 / アルツハイマー病 / δ-セクレターゼ / β-セクレターゼ / アミロイドβ / アミロイドβタンパク / Neuro-vascular Unit … More / Na+ポンプ / 血管周皮細胞（ペリサイト） / Neurovascular unit / 生理学 / 薬理学 / Na+/K+-ATPase / Na+/K+-ATPase alpha 3 / 脳アミロイド血管症 / 一酸化窒素 / eNOS … More Except Principal Investigator 異常凝集体 / アルツハイマー病 / 神経細胞死 / 神経変性疾患 / ペプチド創薬 / タンパク質ータンパク質相互作用 / ナトリウムポンプ / 伝搬 / 治療法 / 診断方法 / コンパニオン診断薬 / 脳神経疾患 Less

Aβ凝集体の広域伝播とtau病態発症の分子機序の解明と早期治療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
アルツハイマー病脳血管障害が神経機能を悪化させる作用機序の解明Principal Investigator
- Principal Investigator
  
  笹原智也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Investigation of the mechanism worsening Alzheimer's disease by vascular endothelial dysfunction in cerebral amyloid angiopathy.Principal Investigator
- Principal Investigator
  
  Sasahara Tomoya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Elucidation of pathogenesis of Alzheimer's disease by the development of diagnostic methods for abnormal aggregates
- Principal Investigator
  
  HOSHI Minako
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates
- Principal Investigator
  
  HOSHI Minako
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
The activity of endothelial NO synthase is suppressed by amylospheroidPrincipal Investigator
- Principal Investigator
  
  Sasahara Tomoya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Foundation for Biomedical Research and Innovation

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells2021
- Author(s)
  Sasahara Tomoya、Satomura Kaori、Tada Mari、Kakita Akiyoshi、Hoshi Minako
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 9 Pages: 102936-102936
- DOI
  10.1016/j.isci.2021.102936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K16022, KAKENHI-PROJECT-20H03457
[Journal Article] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2021
- Author(s)
  Sasahara T, Hoshi M
- Journal Title
  
  STAR Protocol
  
  Volume: 3(1) Issue: 1 Pages: 101053-101053
- DOI
  10.1016/j.xpro.2021.101053
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16022, KAKENHI-PROJECT-20H03457, KAKENHI-PROJECT-22K18380
[Journal Article] NMR-based site-resolved profiling of ホイ-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.2020
- Author(s)
  Yiling Xiao, Isamu Matsuda, Masafumi Inoue, Tomoya Sasahara, Minako Hoshi, Yoshitaka Ishii
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 295 Issue: 2 Pages: 458-467
- DOI
  10.1074/jbc.ra119.008522
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04055, KAKENHI-PROJECT-15K21772, KAKENHI-PROJECT-20H03457
[Journal Article] Alzheimer Abeta Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK3 Neurons by Secretion2019
- Author(s)
  Komura, H., Kakio, S., Sasahara, T., Arai, Y., Takino, N., Sato, M., Satomura, K., Ohnishi, T., Nabesima, Y., Muramatsu, S., Kii, I., and Hoshi, M.
- Journal Title
  
  iScience
  
  Volume: 13 Pages: 452-477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04055
[Presentation] Interaction of Alzheimer patients’ amyloid β oligomer with Na+, K+-ATPase α3 in brain pericytes induces activation of δ-secretase in cortical neurons2023
- Author(s)
  笹原智也、星美奈子
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06643
[Presentation] 「アルツハイマー病由来アミロイドβ凝集体は脳周皮細胞の機能障害を介して神経細胞のδ-secretaseを活性化する: 周皮細胞におけるアミロイドβ凝集体の結合ターゲットの探索」2023
- Author(s)
  笹原智也、星美奈子
- Organizer
  日本薬理学会第97年会 (日本薬理学会主催)、
- Data Source
  KAKENHI-PROJECT-22K18380
[Presentation] The damage of vascular cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases the expression of BACE protein through endothelial cells-derived angiotensin II release.2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K18380
[Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会合同学術会議
- Data Source
  KAKENHI-PROJECT-20H03457
[Presentation] アルツハイマー病アミロイドβ凝集体“アミロスフェロイド”による血管内皮細胞障害はアンジオテンシンIIの遊離を介して神経細胞のBACE発現量を増加する2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20H03457
[Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16022
[Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第96回日本薬理学会年会／第43回日本臨床薬理学会学術総会合同学術会議
- Data Source
  KAKENHI-PROJECT-22K18380
[Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06643
[Presentation] The damage of vascular cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases the expression of BACE protein through endothelial cells-derived angiotensin II release.2022
- Author(s)
  笹原智也、星美奈子
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20H03457
[Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2021
- Author(s)
  笹原智也、星美奈子
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K16022
[Presentation] Establishment of a new tri-culture system for elucidating crosstalk mechanisms between central nervous system and brain microvascular endothelial system in Alzheimer’s disease brains2021
- Author(s)
  笹原智也、星美奈子
- Organizer
  第９４回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20H03457
[Presentation] Highly neurotoxic amyloid-ホイ assemblies from Alzheimer's disease brain, amylospheroids, inhibit endothelial NAKホア3 activity, resulting in the inhibition of eNOS activity in human brain microvascular endothelial cells2020
- Author(s)
  笹原智也
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17H04055
[Presentation] アルツハイマー病患者脳由来アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮のNa+, K+-ATPase α3を介してeNOSを不活性化する(Highly neurotoxic amyloid-β assemblies from Alzheimer's disease brain, amylospheroids, inhibit endothelial NAKα3 activity, resulting in the inhibition of eNOS activity in human brain microvascular endothelial cells)2020
- Author(s)
  笹原智也、里村香織、他田真理、柿田明美、星美奈子
- Organizer
  第93回日本薬理学会年会(神奈川)
- Data Source
  KAKENHI-PROJECT-20H03457
[Presentation] Toxic amyloid-β assemblies, amylospheroids, inactivate eNOS through a NAKα3-mediated ROS/PKC pathway in human brain microvascular endothelial cells.2018
- Author(s)
  笹原智也、里村香織、星美奈子
- Organizer
  第91回日本薬理学会年会 (第18回国際薬理・臨床薬理学会議と合同開催)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21713
[Presentation] Toxic amyloid-beta assemblies, amylospheroids, inactivate eNOS through NAK alpha3-mediated mitochondrial ROS production in human brain microvascular endothelial cells2018
- Author(s)
  Sasahara, T., Satomura, K., Kakita, A., Hoshi, M.
- Organizer
  Gordon Research Conference / Neurobiology of Brain Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04055
[Presentation] Toxic amyloid-β assemblies, amylospheroids, inactivate eNOS through a NAKα-mediated ROS/PKC pathway in human brain microvascular endothelial cells2018
- Author(s)
  笹原智也、里村香織、星美奈子
- Organizer
  「日本薬理学会」「国際薬理・臨床薬理学会」合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04055
[Presentation] アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮においてNAKa3を介したPKC活性化によりeNOS活性を低下する（Toxic amyloid-β assemblies, amylospheroids, inhibit eNOS activity through NAKα3-mediated PKC activation in human brain microvascular endothelial cells）2017
- Author(s)
  笹原智也、里村香織、星美奈子
- Organizer
  第90回日本薬理学会年会（主催日本薬理学会)
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K21713
[Presentation] アミロイドβアセンブリー「アミロスフェロイド」はヒト由来脳微小血管内皮において NAKa3を介したPKC活性化によりeNOS活性を低下する（Toxic amyloid-β assemblies, amylospheroids, inhibit eNOS activity through NAKα3-mediated PKC activation in human brain microvascular endothelial cells）2017
- Author(s)
  笹原智也、里村香織、星美奈子
- Organizer
  第90回日本薬理学会年会（主催日本薬理学会)
- Data Source
  KAKENHI-PROJECT-16K21713

1. HOSHI Minako (30374010)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. 豊島近 (70172210)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 久保厚子 (70647792)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 村松慎一 (10239543)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 廣明秀一 (10336589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 垣尾翔大 (10789085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 石井佳誉 (40799045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 喜井勲 (80401561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林亜希子 (80649046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 柿田明美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 他田真理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasahara Tomoya 笹原 智也

Research Projects

Research Products

Co-Researchers

Aβ凝集体の広域伝播とtau病態発症の分子機序の解明と早期治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病脳血管障害が神経機能を悪化させる作用機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism worsening Alzheimer's disease by vascular endothelial dysfunction in cerebral amyloid angiopathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of Alzheimer's disease by the development of diagnostic methods for abnormal aggregates

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The activity of endothelial NO synthase is suppressed by amylospheroidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NMR-based site-resolved profiling of ホイ-amyloid misfolding reveals structural transitions from pathologically relevant spherical oligomer to fibril.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alzheimer Abeta Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK&#61537;3 Neurons by Secretion2019

Author(s)

Journal Title

Data Source

[Presentation] Interaction of Alzheimer patients’ amyloid β oligomer with Na+, K+-ATPase α3 in brain pericytes induces activation of δ-secretase in cortical neurons2023

Author(s)

Organizer

Data Source

[Presentation] 「アルツハイマー病由来アミロイドβ凝集体は脳周皮細胞の機能障害を介して神経細胞のδ-secretaseを活性化する: 周皮細胞におけるアミロイドβ凝集体の結合ターゲットの探索」2023

Author(s)

Organizer

Data Source

[Presentation] The damage of vascular cells by Alzheimer's amyloid-β assemblies, amylospheroids, increases the expression of BACE protein through endothelial cells-derived angiotensin II release.2022

Author(s)

Organizer

Data Source

[Presentation] High-throughput screening for agonists of ROS production in live human vascular endothelial cells.2022

Author(s)

Organizer

Sasahara Tomoya 笹原智也

[Journal Article] Alzheimer Abeta Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAK3 Neurons by Secretion2019