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Hayashi Junsuke  林 淳祐

ORCIDConnect your ORCID iD *help
Researcher Number 30740295
Other IDs
Affiliation (based on the past Project Information) *help 2021 – 2023: 大阪医科薬科大学, 薬学部, 助教
2016: 大阪薬科大学, 薬学部, 助手(移行)
2015: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Chemical pharmacy
Except Principal Investigator
Basic Section 37010:Bio-related chemistry / Basic Section 55010:General surgery and pediatric surgery-related
Keywords
Principal Investigator
グルタチオン / ジスルフィド / プロドラッグ / siRNA / 核酸医薬
Except Principal Investigator
還元環境応答性 / プロドラッグ型RNA / 無臭性チオール / ジスルフィド / 還元環境応答型 … More / 第二世代 / プロドラッグ型核酸 / siRNA / 化学修飾 / 創薬 / miRNA / 切除不能 / 酸化還元 / DDS / 核酸創薬 / ドラッグデリバリーシステム / 核酸医薬 / microRNA Less
  • Research Projects

    (3 results)
  • Research Products

    (6 results)
  • Co-Researchers

    (4 People)
  •  Second-generation prodrug-type siRNA responsive to intracellular reducing environment

    • Principal Investigator
      浦田 秀仁
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Development of therapeutic strategies for the realization of tumor suppressive microRNA replacement therapy for refractory solid tumors

    • Principal Investigator
      谷口 高平
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Development of prodrug-type siRNA with long term activitiesPrincipal Investigator

    • Principal Investigator
      Hayashi Junsuke
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences

All 2017 2016

All Journal Article Presentation

  • [Journal Article] Syntheses of prodrug-type phosphotriester oligonucleotides responsive to intracellular reducing environment for improvement of cell membrane permeability and nuclease resistance2017

    • Author(s)
      Junsuke Hayashi, Yusuke Samezawa, Yosuke Ochi, Shun-ichi Wada, Hidehito Urata
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: in press Issue: 14 Pages: 3135-3138

    • DOI

      10.1016/j.bmcl.2017.05.031

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K21517
  • [Journal Article] Gene silencing by 2′-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment2016

    • Author(s)
      Yosuke Ochi, Mieko Imai, Osamu Nakagawa, Junsuke Hayashi, Shun-ichi Wada, Hidehito Urata
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Issue: 3 Pages: 845-848

    • DOI

      10.1016/j.bmcl.2015.12.074

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K21517
  • [Presentation] 細胞内還元環境で活性化するプロドラッグ型 siRNAの RNAi 活性の経時変化2017

    • Author(s)
      西垣美沙, 越智 洋輔, 林 淳祐, 和田 俊一, 浦田 秀仁
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K21517
  • [Presentation] 細胞内還元環境下で応答するプロドラッグ型リン酸トリエステル-オリゴ核酸の開発2017

    • Author(s)
      林 淳祐, 鮫澤佑介, 和田俊一, 浦田秀仁
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K21517
  • [Presentation] 細胞内還元環境において活性化する新規プロドラッグ型siRNA (REDUCT-siRNA) の2’-O-methyldithiomethy修飾がRNA干渉能に与える影響2016

    • Author(s)
      林 淳祐, 西垣美沙, 越智洋輔, 和田俊一, 浦田秀仁
    • Organizer
      日本核酸医薬学会第2回年会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2016-11-15
    • Data Source
      KAKENHI-PROJECT-15K21517
  • [Presentation] 細胞内還元環境に応答する2’-プロドラッグ型RNA (REDUCT-RNA) の開発 ―核酸医薬への応用を指向したRNA干渉作用に関する検討―2016

    • Author(s)
      林 淳祐、越智洋輔、和田俊一、浦田秀仁
    • Organizer
      第 66 回 日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2016-10-15
    • Data Source
      KAKENHI-PROJECT-15K21517
  • 1.  谷口 高平 (70779686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  柴田 雅朗 (10319543)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  河村 暁文 (50612579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  浦田 秀仁 (80211085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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