NAGATOMO Hiroaki 長友啓明

… Alternative Names

Nagatomo Hiroaki 長友啓明

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Researcher Number	30746813
Other IDs
Affiliation (Current)	2025: 山梨大学, 大学院総合研究部, 講師
Affiliation (based on the past Project Information) *help	2025: 山梨大学, 大学院総合研究部, 講師 2019 – 2023: 山梨大学, 大学院総合研究部, 講師 2017 – 2019: 山梨大学, 大学院総合研究部, 特任助教 2015 – 2016: 山梨大学, 総合研究部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 43010:Molecular biology-related / Animal production science Except Principal Investigator Integrative animal science / Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator 顕微授精 / 雄性前核 / 雌性前核 / 胚操作 / ゲノム編集 / 発生工学 / 初期胚発生 / 1前核受精卵 / 核小体 / DNAメチル化 … More / 初期胚 / 雌核発生胚 / 雄核発生胚 / 雌雄前核 / 細胞融合 / 胚性ゲノム活性化 / キメラ技術 / 発生 / キメラ個体 / 胚移植 / 始原生殖細胞 / 顕微操作 / 生殖細胞 / マウス胚 / 遺伝資源 / 発生率 … More Except Principal Investigator 染色体 / 核移植 / マウスの遺伝子背景 / ゲノム編集技術 / 抗核抗体価の上昇 / 結合配列 / 転写因子 / miRNA / ゲノム編集 / 血清アミロイドP成分 / 炎症の系統差 / 自己免疫疾患 / 肥満と突然死 / 皮膚疾患 / 免疫反応の系統差 / アレルギー / 核移植絶滅動物 / 卵子 / 顕微授精 / 絶滅動物 / 絶滅危惧種 / 精子 / 凍結乾燥 / 遺伝子資源 / クローン / ライブセルイメージング / 発生工学 / イメージング / 染色体操作 Less

ゲノム編集技術を応用した体細胞クローン技術の革新：絶滅種復活への道Principal Investigator
- Principal Investigator
  
  長友啓明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  University of Yamanashi
1前核受精卵の効率的作製方法の開発と正常性の網羅的調査Principal Investigator
- Principal Investigator
  
  長友啓明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  University of Yamanashi
Analysis of male and female genomes in one-cell stage mouse zygotes using the method of producing male-female haploid fusion embryosPrincipal Investigator
- Principal Investigator
  
  Nagataomo Hiroaki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of Yamanashi
Analysis of the mechanism of increase in antinuclear antibody levels due to differences in genetic background of mice
- Principal Investigator
  
  ITO Sadahiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  University of Yamanashi
Efficient chimeric mouse production technology using germ cell-deficient embryosPrincipal Investigator
- Principal Investigator
  
  Nagatomo Hiroaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Animal production science
- Research Institution
  University of Yamanashi
Feasibility Study for the generation of live cell from extinct or endangered animal
- Principal Investigator
  
  WAKAYAMA Teruhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Integrative animal science
- Research Institution
  University of Yamanashi
Analysis of individual chromosome dynamics in living embryo and establishment of next generation embryo manipulation technique by chromosome transfer
- Principal Investigator
  
  MIZUTANI EIJI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2018 2017 2016 Other

All Journal Article Presentation Other

[Journal Article] Removal of sperm tail using trypsin and pre-activation of oocyte facilitates intracytoplasmic sperm injection in mice and rats2023
- Author(s)
  TORIKAI Kohei、SHIMIZU Kazuma、NAGATOMO Hiroaki、KASAI Mariko、KATO-ITOH Megumi、KAMADA Yuko、SHIBASAKI Ikue、JEON Hyojung、KIKUCHI Riko、WAKAYAMA Sayaka、SUCHY Fabian、NAKAUCHI Hiromitsu、WAKAYAMA Teruhiko、MIZUTANI Eiji
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 69 Issue: 1 Pages: 48-52
- DOI
  10.1262/jrd.2022-065
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03638, KAKENHI-PROJECT-22K09637, KAKENHI-PROJECT-19K16040
[Journal Article] Ubap1 knock-in mice reproduced the phenotype of SPG802022
- Author(s)
  Shimozono K, Nan H, Takiyama Y, et al.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 67 Issue: 12 Pages: 679-686
- DOI
  10.1038/s10038-022-01073-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07456, KAKENHI-PROJECT-22K09637, KAKENHI-PROJECT-22K19356, KAKENHI-PROJECT-19K16040, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-21H04786, KAKENHI-PROJECT-20K08902, KAKENHI-PROJECT-21K19309, KAKENHI-PUBLICLY-21H00192, KAKENHI-PROJECT-23K23980
[Journal Article] Adenosine A2B receptor down‐regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development2021
- Author(s)
  Tanaka Masayoshi、Shigetomi Eiji、Parajuli Bijay、Nagatomo Hiroaki、Shinozaki Youichi、Hirayama Yuri、Saito Kozo、Kubota Yuto、Danjo Yosuke、Lee Ji Hwan、Kim Sun Kwang、Nabekura Junichi、Koizumi Schuichi
- Journal Title
  
  Glia
  
  Volume: 69 Issue: 11 Pages: 2546-2558
- DOI
  10.1002/glia.24006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PLANNED-20H05902, KAKENHI-PROJECT-20H00500, KAKENHI-PROJECT-21K19309, KAKENHI-PROJECT-19K16040, KAKENHI-PROJECT-20KK0366, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21H04786
[Journal Article] A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation2020
- Author(s)
  Abe Shusaku、Nagatomo Hiroaki、Sasaki Hiroyuki、Ishiuchi Takashi
- Journal Title
  
  Epigenetics
  
  Volume: Online ahead of print Issue: 10 Pages: 1-12
- DOI
  10.1080/15592294.2020.1841873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16040, KAKENHI-PLANNED-19H05756
[Journal Article] Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction2018
- Author(s)
  Tsukiji Nagaharu、Inoue Osamu、Morimoto Mitsuru、Tatsumi Norifumi、Nagatomo Hiroaki、Ueta Koji、Shirai Toshiaki、Sasaki Tomoyuki、Otake Shimon、Tamura Shogo、Tachibana Toshiaki、Okabe Masataka、Hirashima Masanori、Ozaki Yukio、Suzuki-Inoue Katsue
- Journal Title
  
  Blood
  
  Volume: 132 Issue: 11 Pages: 1167-1179
- DOI
  10.1182/blood-2017-12-823369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19910, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-17K16185, KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-16K19572
[Journal Article] Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development of the bovine blastocyst.2018
- Author(s)
  Hiroki Akizawa, Ken Kobayashi , Hanako Bai, Masashi Takahashi, Shinjiro Kagawa, Hiroaki Nagatomo, Manabu Kawahara
- Journal Title
  
  Reproduction
  
  Volume: 印刷中 Issue: 6 Pages: 563-571
- DOI
  10.1530/rep-18-0043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J01122, KAKENHI-PROJECT-16K14587, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-17K15357
[Journal Article] Production of cloned mice using oocytes derived from ICR-outbred strain.2017
- Author(s)
  Tanabe Y, Kuwayama H, Wakayama S, Nagatomo H, Ooga M, Kamimura S, Kishigami S, Wakayama T.
- Journal Title
  
  Reproduction
  
  Volume: 154(6) Issue: 6 Pages: 859-866
- DOI
  10.1530/rep-17-0372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-16J07536
[Journal Article] The Number of Point Mutations In iPS Cells and ntES Cells Depends on the Method and Somatic Cell Type Employed for Their Generation.2017
- Author(s)
  Araki R, Mizutani E, Hoki Y, Sunayama M, Wakayama S, Nagatomo H, Kasama Y, Nakamura M, Wakayama T, Abe M.
- Journal Title
  
  Stem Cells
  
  Volume: 35 Issue: 5 Pages: 1189-1196
- DOI
  10.1002/stem.2601
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-26506006, KAKENHI-PROJECT-17K15359
[Journal Article] Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months2017
- Author(s)
  Sayaka Wakayama, Yuko Kamada, Kaori Yamanaka, Takashi Kohda, Hiromi Suzuki, Toru Shimazu,
- Journal Title
  
  PNAS
  
  Volume: 1 Issue: 23 Pages: 1-6
- DOI
  10.1073/pnas.1701425114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26506032, KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-16J07536, KAKENHI-PROJECT-16H02478, KAKENHI-PROJECT-16H02593, KAKENHI-PUBLICLY-17H05597, KAKENHI-PROJECT-17K07498, KAKENHI-PROJECT-26430087
[Journal Article] Agarose capsules as new tools for protecting denuded mouse oocytes/embryos during handling and freezing-thawing and supporting embryonic development in vivo.2017
- Author(s)
  Nagatomo H, Yao T, Araki Y, Mizutani E, Wakayama T.
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 17960-17960
- DOI
  10.1038/s41598-017-18365-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15359, KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-15H04605
[Journal Article] Effect of Long-Term Exposure of Donor Nuclei to the Oocyte Cytoplasm on Production of Cloned Mice Using Serial Nuclear Transfer.2016
- Author(s)
  Wakayama S, Tanabe Y, Nagatomo H, Mizutani E, Kishigami S, Wakayama T.
- Journal Title
  
  Cell Reprogram
  
  Volume: 18 Issue: 6 Pages: 382-389
- DOI
  10.1089/cell.2016.0026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-26506006
[Journal Article] Generation of cloned mice and nuclear transfer embryonic stem cell lines from urine-derived cells.2016
- Author(s)
  Mizutani E, Torikai K, Wakayama S, Nagatomo H, Ohinata Y, Kishigami S, Wakayama T.
- Journal Title
  
  Scientific Reports.
  
  Volume: 6 Issue: 1 Pages: 23808-23808
- DOI
  10.1038/srep23808
- NAID
  130007023594
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23248048, KAKENHI-PROJECT-15H04605, KAKENHI-PROJECT-16H02593, KAKENHI-PROJECT-25712030, KAKENHI-PROJECT-26506006
[Presentation] Development of vaginal image-based murine estrus detection system by deep le arning2020
- Author(s)
  標智仁・兼平雅彦・神沼修・長友啓明
- Organizer
  日本実験動物学科
- Data Source
  KAKENHI-PROJECT-19K16040
[Presentation] Development of vaginal image-based murine estrus detection system by deep le arning2020
- Author(s)
  標智仁、兼平雅彦、神沼修、長友啓明
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-17K15359
[Presentation] 色体分配異常を起こしたマウス受精胚における異常染色体の回収と同定の試み2018
- Author(s)
  柴﨑郁江・鎌田裕子・長友啓明・大我政敏・若山照彦
- Organizer
  第59回日本卵子学会
- Data Source
  KAKENHI-PROJECT-17K15359
[Presentation] Production of cloned mice using oocytes derived from ICR strain.2017
- Author(s)
  Yoshiaki Tanabe, Hiroki Kuwayama, Sayaka Wakayama, Hiroaki Nagatomo, Masatoshi Ooga, Satoshi Kamimura, Satoshi Kishigami, and Teruhiko Wakayama
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02593
[Presentation] Developmental competence of mouse oocytes activated by injection of PLCζ from different species2017
- Author(s)
  Yunosuke Yamamoto, Masatoshi Ooga, Satoshi Kamimura, Hiroaki Nagatomo, Sayaka Wakayama, Junya Ito, and Teruhiko Wakayama
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02593
[Presentation] Improvement of freeze-drying preservation method of spermatozoa at room temperature.2017
- Author(s)
  Yuko Kamada, Daiyu Ito, Ikue Shibasaki, Satoshi Kamimura, Hiroaki Nagatomo, Masatoshi Ooga, Sayaka Wakayama and Teruhiko Wakayama
- Organizer
  4th World Congress of Reproductive Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02593
[Presentation] Agarose capsules as new tools for protecting denuded mouse oocytes/embryos during handling and freezing-thawing and supporting embryonic development in vivo2017
- Author(s)
  Hiroaki Nagatomo, Tatsuma Yao, Yasuyuki Araki, Eiji Mizutani, Teruhiko Wakayama
- Organizer
  World Congress of Reproductive Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15359
[Presentation] Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months.2017
- Author(s)
  Wakayama S, Kamada Y, Yamanaka K, Kohda T, Suzuki H, Shimazu T, Tada MN, Osada I, Nagamatsu A, Kamimura S, Nagatomo H, Mizutani E, Ishino F, Yano S, Wakayama T.
- Organizer
  World Congress of Reproductive Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15359
[Presentation] Developmental competence of mouse oocyte activeted by different species of PLCζ2017
- Author(s)
  Yamamoto Y, Ooga M, Kamimura S, Nagatomo H, Wakayama S, Ito J, Wakayama T
- Organizer
  World Congress of Reproductive Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15359
[Presentation] マウス2細胞期胚において分配異常を起こした染色体の回収と同定の試み2016
- Author(s)
  柴﨑郁江、鎌田裕子、鳥飼昂平、長友啓明、水谷英二、若山照彦
- Organizer
  109回日本繁殖生物学会
- Place of Presentation
  麻布大学神奈川県
- Year and Date
  2016-09-12
- Data Source
  KAKENHI-PROJECT-16H02593
[]

1. MIZUTANI EIJI (80443034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. WAKAYAMA Teruhiko (40360672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. ITO Sadahiro (30345722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岸上哲士 (10291064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 大我政敏 (40644886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 神沼修 (80342921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村勇規 (90580465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. WAKAYAMA Sayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. SHINOZAKI Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 田村彰吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐々木知幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 滝山嘉久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGATOMO Hiroaki 長友 啓明

Nagatomo Hiroaki 長友 啓明

Research Projects

Research Products

Co-Researchers

ゲノム編集技術を応用した体細胞クローン技術の革新：絶滅種復活への道Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

1前核受精卵の効率的作製方法の開発と正常性の網羅的調査Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of male and female genomes in one-cell stage mouse zygotes using the method of producing male-female haploid fusion embryosPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism of increase in antinuclear antibody levels due to differences in genetic background of mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Efficient chimeric mouse production technology using germ cell-deficient embryosPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Feasibility Study for the generation of live cell from extinct or endangered animal

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of individual chromosome dynamics in living embryo and establishment of next generation embryo manipulation technique by chromosome transfer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Removal of sperm tail using trypsin and pre-activation of oocyte facilitates intracytoplasmic sperm injection in mice and rats2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Ubap1 knock-in mice reproduced the phenotype of SPG802022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adenosine A2B receptor down‐regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reciprocal regulation of TEAD4 and CCN2 for the trophectoderm development of the bovine blastocyst.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of cloned mice using oocytes derived from ICR-outbred strain.2017

NAGATOMO Hiroaki 長友啓明

Nagatomo Hiroaki 長友啓明