Watanabe Mitsuru 渡邉充

Researcher Number	30748009
Affiliation (Current)	2025: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 九州大学, 大学病院, 助教 2021: 九州大学, 医学研究院, 助教 2018 – 2019: 九州大学, 医学研究院, 助教 2018: 九州大学, 病院, 助教 2016 – 2017: 九州大学, 大学病院, 医員 2015: 九州大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields / Neurology
Keywords	Principal Investigator 多発性硬化症 / バイオマーカー / 免疫細胞 / 環境因子 / グリア細胞 / ミクログリア / アストロサイト / 中枢神経脱髄疾患 / 病理 / 中枢神経自己免疫疾患 … More / 治療選択 / 予後不良因子 / 視神経脊髄炎スペクトラム障害 / 遺伝的要因 / 腸内細菌叢 / 米 / 食事 / 疾患修飾薬 / 免疫細胞解析 / 喫煙 / コメ摂取 / 脱髄疾患 / 軸索障害 / 乳酸担体 / 視神経脊髄炎 / ニューロフィラメント / GFAP / グルコース担体 / Balo病 / 視神経脊髄炎関連疾患 / 中枢神経脱髄性疾患 / サイトカイン / T細胞 / Cx43 / インターフェロンγ / Th1細胞 / ギャップ結合 / コネキシン … More Except Principal Investigator 多発性硬化症 / コネキシン / 脱髄 / ギャップ結合 / アストロサイト / オリゴデンドロサイト / シヌクレイン / 多系統萎縮症 / 自己抗体 / 脱髄疾患 / アストログリア / B細胞 / 重症化 / エクソソーム / 視神経脊髄炎スペクトラム障害 / 神経炎症 / バイオマーカー / 神経内科疾患 / 神経障害性疼痛 / 神経免疫疾患 / 視神経脊髄炎 / オリゴデンドログリア / ミクログリア / CD20陽性T細胞 / 抗CD20抗体 / 免疫治療 / IgG4 / 自己免疫性ノドパチー / mRNA品質管理機構 / 重症化因子 / 中枢神経系自己免疫性疾患 / グリア由来エキソソーム / グリア / マイクロRNA / イソフォーム / グリア線維性蛋白 / 実験的自己免疫性脳脊髄炎 / 二次進行型 / エキソソーム / グリア炎症 / グリア細胞 / 脊髄障害 / BKチャネル / KCNMA1 / 進行型多発性硬化症 / 小脳型多系統萎縮症 / グリア標的治療 / グリオパチー / α-シヌクレイン / α―シヌクレイン / 小脳失調 / αーシヌクレイン / 神経変性疾患 / 遺伝環境リスク / 抗核抗体 / PlexinD1 / NF155 / 慢性炎症性脱髄性多発神経根炎 / ノド抗体 / アトピー性脊髄炎 / アトピー / 環境因子 / 遺伝子 / 自己免疫 / 慢性炎症性脱髄性多発神経炎 / 進行性多層背白質脳症 / HLA / JCウイルス / 疾患修飾薬 / 進行性多巣性白質脳症 / TGFbeta / イルベサルタン / 動物モデル / 肥厚性硬膜炎 Less

Estimation of Underlying Pathologies and Pursuit of Personalized Treatments for Central Nervous System Autoimmune Diseases Using BiomarkersPrincipal Investigator
- Principal Investigator
  
  渡邉充
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyushu University
Elucidation of inflammation regulatory mechanisms in central nervous system autoimmune diseases
- Principal Investigator
  
  磯部紀子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Single-cell analysis of autoantigen-specific B cells in autoimmune nodopathy
- Principal Investigator
  
  緒方英紀
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
コネキシン43結合性マイクロRNAを介する多発性硬化症重症化機構の解明と治療開発
- Principal Investigator
  
  中村優理
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
免疫学的視点からみた中枢性神経障害性疼痛の病態解明ならびに新規治療法開発
- Principal Investigator
  
  藤井敬之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
CD20陽性T細胞とB細胞に注目した多発性硬化症病態の解明
- Principal Investigator
  
  篠田紘司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
ヘミチャネル阻害薬を用いたαシヌクレイン伝播阻止による多系統萎縮症の治療法開発
- Principal Investigator
  
  真崎勝久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立Principal Investigator
- Principal Investigator
  
  渡邉充
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyushu University
Exacerbation of demyelination by glia connexin truncated isoform-expressing exosomes and its therapy development
- Principal Investigator
  
  Nakamura Yuri
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channel
- Principal Investigator
  
  Matsushita Takuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Novel therapy for progressive multiple sclerosis and multiple system atrophy by glial regulation
- Principal Investigator
  
  Katsuhisa Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Development of treatment for multiple sclerosis based on rice consumption, a newly identified environmental risk factorPrincipal Investigator
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation and Prevention of Progressive Multifocal Leukoencephalopathy Induced by Disease-Modifying Drugs in Japanese Patients with Multiple Sclerosis
- Principal Investigator
  
  Kawano Yuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Kyushu University
Development of a new treatment for CNS demyelinating disorders targeting glucose and monocarboxylate transporterPrincipal Investigator
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Development of a novel treatment strategy based on the mechanisms that pathogenic T cells induce loss of glial connexins in CNS demyelinating disordersPrincipal Investigator
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis2023
- Author(s)
  Leppert David、Watanabe Mitsuru、Schaedelin Sabine、Piehl Fredrik、Furlan Roberto、Matsushita Takuya、Masaki Katsuhisa、Isobe Noriko、Kira Jun-ichi、Willemse Eline、Oechtering Johanna、Orleth Annette、Meier Stephanie、Kuhle Jens
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 94 Issue: 9 Pages: 726-737
- DOI
  10.1136/jnnp-2022-330796
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-23K06965
[Journal Article] Iguratimod Ameliorates the Severity of Secondary Progressive Multiple Sclerosis in Model Mice by Directly Inhibiting IL-6 Production and Th17 Cell Migration via Mitigation of Glial Inflammation2023
- Author(s)
  Nagata Satoshi、Yamasaki Ryo、Takase Ezgi Ozdemir、Iida Kotaro、Watanabe Mitsuru、Masaki Katsuhisa、Wijering Marion Heleen Cath?rine、Yamaguchi Hiroo、Kira Jun-ichi、Isobe Noriko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 9 Pages: 1217-1217
- DOI
  10.3390/biology12091217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-22K07540, KAKENHI-PROJECT-23K06965
[Journal Article] Effect of smoking on disease activity in multiple sclerosis patients treated with dimethyl fumarate or fingolimod2023
- Author(s)
  Tanaka E, Watanabe M, Fukumoto S, Masaki K, Yamasaki R, Matsushita T, Isobe N
- Journal Title
  
  Mult Scler Relat Disord
  
  Volume: - Pages: 104513-104513
- DOI
  10.1016/j.msard.2023.104513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464, KAKENHI-PROJECT-22K07351, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-23K06965
[Journal Article] Early and extensive alterations of glial connexins, distal oligodendrogliopathy type demyelination, and nodal/paranodal pathology are characteristic of multiple system atrophy2022
- Author(s)
  Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Tatsunori Tanaka1, Eriko Matsuo, Shotaro Hayashida, Mitsuru Watanabe, Takuya Matsushita, Shoko Sadashima, Naokazu Sasagasako, Ryo Yamasaki, Noriko Isobe, Toru Iwaki, Jun-ichi Kira
- Journal Title
  
  Brain Pathology
  
  Volume: - Issue: 3 Pages: 1-16
- DOI
  10.1111/bpa.13131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07438, KAKENHI-PROJECT-22K07540, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-21K20873, KAKENHI-PROJECT-23K18266, KAKENHI-PROJECT-23K19567, KAKENHI-PROJECT-23K06965
[Journal Article] Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis2022
- Author(s)
  Fukumoto S, Watanabe M, Masaki K, Matsushita T, Isobe N, Kira JI, et al.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 9 Issue: 3
- DOI
  10.1212/nxi.0000000000001147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-21K07464
[Journal Article] A new clustering method identifies multiple sclerosis‐specific T‐cell receptors2021
- Author(s)
  Hayashi Fumie、Isobe Noriko、Glanville Jacob、Matsushita Takuya、Maimaitijiang Guzailiayi、Fukumoto Shoko、Watanabe Mitsuru、Masaki Katsuhisa、Kira Jun‐ichi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 8 Issue: 1 Pages: 163-176
- DOI
  10.1002/acn3.51264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K22910
[Journal Article] HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data2021
- Author(s)
  Watanabe M. Nakamura Y. Sato S. Niino M. Fukaura H. Tanaka M. Ochi H. et al
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 607-607
- DOI
  10.1038/s41598-020-79833-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07997, KAKENHI-PROJECT-20K07899, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07467, KAKENHI-PROJECT-21K11165
[Journal Article] Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod2020
- Author(s)
  Watanabe Mitsuru、Nakamura Yuri、Isobe Noriko、Tanaka Masami、Sakoda Ayako、Hayashi Fumie、Kawano Yuji、Yamasaki Ryo、Matsushita Takuya、Kira Jun-ichi
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 206-206
- DOI
  10.1186/s12974-020-01865-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07997, KAKENHI-PROJECT-19H01045
[Journal Article] Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Bal?'s disease and neuromyelitis optica spectrum disorders2020
- Author(s)
  Hayashida Shotaro、Masaki Katsuhisa、Suzuki Satoshi O.、Yamasaki Ryo、Watanabe Mitsuru、Koyama Sachiko、Isobe Noriko、Matsushita Takuya、Takahashi Kazuya、Tabira Takeshi、Iwaki Toru、Kira Jun‐ichi
- Journal Title
  
  Brain Pathology
  
  Volume: 30 Issue: 6 Pages: 1144-1157
- DOI
  10.1111/bpa.12898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis2020
- Author(s)
  Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira J.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 4 Pages: 2160-2169
- DOI
  10.1073/pnas.1901294117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis2020
- Author(s)
  Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 413 Pages: 116768-116768
- DOI
  10.1016/j.jns.2020.116768
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-19K21317
[Journal Article] Genetic factors for susceptibility to and manifestations of neuromyelitis optica2020
- Author(s)
  Matsushita Takuya、Masaki Katsuhisa、Isobe Noriko、Sato Shinya、Yamamoto Ken、Nakamura Yuri、Watanabe Mitsuru、Suenaga Toshihiko、Kira Jun‐ichi、the Japan Multiple Sclerosis Genetic Consortium
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 7 Issue: 11 Pages: 2082-2093
- DOI
  10.1002/acn3.51147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07869, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-18K07529
[Journal Article] Environmental risk factors for multiple sclerosis in Japanese people2020
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J.
- Journal Title
  
  Multiple Sclerosis and Related Disorders
  
  Volume: 38 Pages: 101872-101872
- DOI
  10.1016/j.msard.2019.101872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K07995, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889
[Journal Article] Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD2019
- Author(s)
  Watanabe M, Nakamura Y, Michalak Z, Isobe N, Barro C, Leppert D, Matsushita T, Hayashi F, Yamasaki R, Kuhle J, Kira J.
- Journal Title
  
  Neurology
  
  Volume: 93 Issue: 13
- DOI
  10.1212/wnl.0000000000008160
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470
[Journal Article] Oral phase dysphagia in facial onset sensory and motor neuronopathy.2018
- Author(s)
  Watanabe M, et al.
- Journal Title
  
  Brain Behav.
  
  Volume: 8 Issue: 6
- DOI
  10.1002/brb3.999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19663
[Journal Article] The relationship between Th1 cells and astrocytic connexin 43 gap junctions in multiple sclerosis.2017
- Author(s)
  Watanabe M, Yamasaki R, Kira J.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19489
[Journal Article] Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 38387-38387
- DOI
  10.1038/srep38387
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-25117001, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-16H02657, KAKENHI-PROJECT-26461295, KAKENHI-PROJECT-15K15341, KAKENHI-PROJECT-15K19489
[Presentation] 中枢神経自己免疫性疾患におけるステロイド使用と椎体骨折との関連2024
- Author(s)
  吉良雄一、山崎友梨乃、渡邉充、田中栄蔵、篠田紘司、眞﨑勝久、磯部紀子
- Organizer
  神経免疫班合同半会議
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] Clinical Features of Eight Patients Presenting with Concentric Lesions like Balo's Concentric Sclerosis2023
- Author(s)
  Kazunori Iwao, Katsuhisa Masaki, Yuichi Kira, Eizo Tanaka, Mitsuru Watanabe, Koji Shinoda, Takeshi Miura, Noriko Isobe
- Organizer
  the 15th Congress of the Pan-Asian Committee on Treatment and Research in Multiple Sclerosis (PACTRIMS) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] Exosome GJA1-29k is a blood marker for progressive multiple sclerosis reflecting glial inflammation2023
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Ayako Sakoda, Katsuhisa Masaki, Mitsuru Watanabe, Satoshi Nagata, Ezgi Ozdemir, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura, Yuri Nakamura
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] 多発性硬化症におけるγδ型T細胞の病態関与と治療反応性バイオマーカーとしての有用性の検討2023
- Author(s)
  渡邉充, 松尾江梨子, 篠田紘司, 田中栄蔵, 小栁文乃, 福元尚子, 眞﨑勝久, 松下拓也, 吉良潤一, 磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 多発性硬化症におけるγδ型T細胞の病態関与と治療反応性バイオマーカーとしての有用性の検討2023
- Author(s)
  渡邉充、松尾江梨子、篠田紘司、田中栄蔵、小柳彩乃、福元尚子、眞﨑勝久、松下拓哉、吉良潤一、磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] 多発性硬化症における頭部全脊髄MRIでの多発T2病変とフマル酸ジメチルによる再発抑制効果との関連性の検討2023
- Author(s)
  田中栄蔵、渡邉充、篠田紘司、眞﨑勝久、松下拓哉、磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] Factors Associated with Glatiramer Acetate Efficacy in Japanese Multiple Sclerosis.2022
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Koki Suezumi, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe.
- Organizer
  14th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Association between HLA subtype and efficacy of glatiramer acetate in Japanese multiple sclerosis.2022
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 当科で経験したBalo病6例の臨床的特徴および画像所見に関する検討2022
- Author(s)
  眞崎勝久, 松下拓也, 渡邉充, 福元尚子, 田中栄蔵, 磯部紀子
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07889
[Presentation] 日本人多発性硬化症患者における高次脳機能とMRIパラメータ変化との関連.2022
- Author(s)
  福元尚子, 渡邉充, 新野正明, 松下拓也, 眞﨑勝久, 迫田礼子, 林史恵, 吉良潤一, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Low gray matter volume can predict cognitive decline in Japanese patients with multiple sclerosis.2022
- Author(s)
  Shoko Fukumoto, Mitsuru Watanabe, Masaaki Niino, Katsuhisa Masaki, Takuya Matsushita, Ayako Sakoda, Fumie Hayashi, Jun-ichi Kira, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 日本人多発性硬化症患者におけるグラチラマー酢酸塩の有効性に関与する因子の検討.2022
- Author(s)
  田中栄蔵, 渡邉充, 福元尚子, 眞﨑勝久, 松下拓也, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Exosomal GJA1-29k translational isoform is a novel blood biomarker for neuroinflammation in neuromyelitis optica.2022
- Author(s)
  Guzailiayi Maimaitijiang, Jun-ichi Kira, Yuri Nakamura, Mitsuru Watanabe, Ayako Sakoda, Katsuhisa Masaki, Satoshi Nagata, Hiroo Yamaguchi, Ryo Yamasaki, Noriko Isobe, Xu Zhang, Tomohiro Imamura
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Association between HLA subtype and efficacy of glatiramer acetate in Japanese multiple sclerosis2022
- Author(s)
  田中栄蔵、渡邉充、福元尚子、眞﨑勝久、松下拓也、磯部紀子
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Dimethyl fumarate treatment showed unique change of γδ T cell subsets in multiple sclerosis patients2022
- Author(s)
  渡邉充、松尾江梨子、福元尚子、田中栄蔵、眞﨑勝久、松下拓也、吉良潤一、磯部紀子
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 視神経脊髄炎(NMOSD)再発時の神経障害と関連する新規血液エクソソーム(Ex)マーカー2022
- Author(s)
  グザリアイ・ママティジャン, 中村優理, 渡邉充, 迫田礼子, 今村友裕, 張旭, 磯部紀子, 吉良潤一
- Organizer
  第34回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07467
[Presentation] Dimethyl fumarate treatment showed unique change of γδ T cell subsets in multiple sclerosis patients2022
- Author(s)
  Mitsuru Watanabe, Eriko Matsuo, Shoko Fukumoto, Eizo Tanaka, Katsuhisa Masaki, Takuya Matsushita, Jun-ichi Kira, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Smoking effect on disease activity in relapsing-remitting multiple sclerosis patients treated with fingolimod or dimethyl fumarate2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  PACTRIMS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 再発寛解型多発性硬化症におけるfingolimod内服下での喫煙と再発の検討2021
- Author(s)
  田中栄蔵、渡邉充、松下拓也、吉良潤一、磯部紀子
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Smoking is a risk factor of relapse in patients with relapsing-remitting multiple sclerosis under fingolimod treatment2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  ECTRIMS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Correlation between cognitive and brain MRI parameters in Japanese patients with multiple sclerosis.2021
- Author(s)
  Shoko Fukumoto, Mitsuru Watanabe, Masaaki Niino, Katsuhisa Masaki, Takuya Matsushita, Ayako Sakoda, Fumie Hayashi, Jun-ichi Kira, Noriko Isobe
- Organizer
  ECTRIMS 2021 The Digital Experience 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Association between smoking and relapse in patients with relapsing-remitting multiple sclerosis under fingolimod treatment2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Takuya Matsushita, Noriko Isobe
- Organizer
  WCN 2021 (XXV World Congress of Neurology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Serum glial fibrillary acidic protein, but not S100B or neurofilament light chain predicts future relapses in neuromyelitis optica spectrum disorders.2020
- Author(s)
  Watanabe M, Isobe N, Matsushita T, Maceski AM, Nakamura Y, Masaki K, Kira J, Leppert D, Kuhle J
- Organizer
  MSVirtual2020 (8th Joint ACTRIMS-ECTRIMS Meeting)
- Invited
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Protective effect of rice on multiple sclerosis susceptibility via CD4+ effector T cell reduction2020
- Author(s)
  Sakoda A, Matsushita T, Watanabe M, Maimaitijiang G, Shinoda K, Isobe N, Kira J.
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Drug targets for multiple system atrophy and primary progressive multiple sclerosis by a novel model2020
- Author(s)
  Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Tatsunori Tanaka, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  61ｓｔ Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Gene expression profile of multiple system atrophy/primary progressive multiple sclerosis mice model2020
- Author(s)
  Hiroo Yamaguchi, Tasunori Tanaka, Dai Mtasuse, Yuji Nishimura, Katsuhisa Masaki, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka, Jun-ichi Kira
- Organizer
  61ｓｔ Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] Therapeutic drug search using model mice for multiple system atrophy and primary progressive multiple sclerosis2020
- Author(s)
  Tatsunori Tanaka, Yuji Nishimura, Katsuhisa Masaki, Dai Matsuse, Hiroo Yamaguchi, Toru Saiga, Mitsuru Watanabe, Ryo Yamasaki, Kenji Tanaka and Jun-ichi Kira
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K20470
[Presentation] A novel risk molecule associated with neurological impairment identified by genome-wide association studies for neuromyelitis optica.2019
- Author(s)
  Takuya Matsushita, Katsuhisa Masaki, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  The 6th MS Summer College in Fukuoka. 2019.8.3. Fukuoka, Japan.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症発症リスクにHLAアリル多型が関与する2019
- Author(s)
  渡邉充、中村優理、磯部紀子、田中正美、松下拓也、河野祐治、迫田礼子、林史恵、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 日本人における視神経脊髄炎の環境要因についての検討2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genome-wide association studies for neuromyelitis optica and the clinical phenotypes.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Ayako Sakoda, Takuya Matsushita, Yuri Nakamura, Mitsuru Watanabe, Koji Shinoda, Noriko Isobe, Jun-ichi Kira
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.24. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Genetic studies on Japanese multiple sclerosis and neuromyelitis optica spectrum disorders.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 米食の予防効果は多発性硬化症でみられるが視神経脊髄炎関連疾患ではみられない2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第37回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Effect of HLA class II alleles on JCV infection in Japanese patients with multiple sclerosis2019
- Author(s)
  Watanabe M, Nakamura Y, Isobe N, Tanaka M, Sakoda A, Hayashi F, Matsushita T, Kira J.
- Organizer
  35th Congress of ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Isobe N, Kira J.
- Organizer
  60th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 血清GFAPとニューロフィラメント軽鎖は視神経脊髄炎関連疾患や多発性硬化症の障害度や再発率と相関する2018
- Author(s)
  渡邉　充ら
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in neuromyelitis optica spectrum disorders2018
- Author(s)
  Watanabe M, et al.
- Organizer
  ECTRIMS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as potential biomarkers for disease activity and disability in neuromyelitis optica spectrum disorders and multiple sclerosis2018
- Author(s)
  Watanabe M, et al.
- Organizer
  PACTRIMS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] IFN-gamma inhibit the expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Suzumura A, Kira J
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市（神戸コンベンションセンター）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFN-gamma inhibit the expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  渡邉　充
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFNγはミクログリアにIL-1β/TNFαを産生させてアストロサイトコネキシン43発現を低下させる2016
- Author(s)
  渡邉充、眞﨑勝久、山﨑亮、川ノ口潤、竹内英之、錫村明生、吉良潤一
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎（長崎ブリックホール）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFNγ reduces expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Suzumura A, Kira J
- Organizer
  32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  ロンドン (ExCeL London)
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1 cells inhibit the expression of connexins in astrocytes2015
- Author(s)
  Mitsuru Watanabe
- Organizer
  31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1 cells inhibit the expression of connexins in astrocytes2015
- Author(s)
  渡邉　充
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1細胞によるアストロサイトのコネキシン発現抑制作用2015
- Author(s)
  渡邉　充
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-15K19489

1. Kira Jun-ichi (40183305)

# of Collaborated Projects: 11 results

# of Collaborated Products: 31 results
2. 山崎亮 (10467946)

# of Collaborated Projects: 11 results

# of Collaborated Products: 6 results
3. Katsuhisa Masaki (90612903)

# of Collaborated Projects: 9 results

# of Collaborated Products: 12 results
4. Matsushita Takuya (00533001)

# of Collaborated Projects: 9 results

# of Collaborated Products: 35 results
5. 磯部紀子 (60452752)

# of Collaborated Projects: 8 results

# of Collaborated Products: 37 results
6. Nakamura Yuri (40822375)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
7. 山口浩雄 (00701830)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
8. 篠田紘司 (70747998)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
9. 松瀬大 (70596395)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
10. Maimaitijiang Guzailiayi (60887107)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
11. 藤井敬之 (30822481)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 緒方英紀 (90778838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 今村友裕 (30725122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
14. Kawano Yuji (20333479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 萬谷博 (20321870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 海田賢一 (40531190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 立川正憲 (00401810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 迫田礼子 (70972230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松本省二 (00570772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMASAKI Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
21. MASAKI Katsuhisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. SUZUMURA Akio

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. TAKEUCHI Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. KAWANOKUCHI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Watanabe Mitsuru 渡邉 充

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Estimation of Underlying Pathologies and Pursuit of Personalized Treatments for Central Nervous System Autoimmune Diseases Using BiomarkersPrincipal Investigator

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中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立Principal Investigator

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Development of treatment for multiple sclerosis based on rice consumption, a newly identified environmental risk factorPrincipal Investigator

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Watanabe Mitsuru 渡邉充