Watanabe Mitsuru 渡邉充

Researcher Number	30748009
Affiliation (Current)	2021: 九州大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2019 – 2020: 九州大学, 大学病院, 助教 2018 – 2019: 九州大学, 医学研究院, 助教 2018: 九州大学, 病院, 助教 2016 – 2017: 九州大学, 大学病院, 医員 2015: 九州大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / Neurology / General internal medicine and related fields
Keywords	Principal Investigator 多発性硬化症 / 中枢神経脱髄疾患 / アストロサイト / ミクログリア / グリア細胞 / コネキシン / ギャップ結合 / Th1細胞 / インターフェロンγ / Cx43 … More Except Principal Investigator 多発性硬化症 / コネキシン / ミクログリア / 視神経脊髄炎 / アストロサイト / 多系統萎縮症 / シヌクレイン / オリゴデンドロサイト / アストログリア / オリゴデンドログリア / 肥厚性硬膜炎 / 動物モデル / イルベサルタン / TGFbeta / BKチャネル / 脊髄障害 / グリア炎症 / 進行性多層背白質脳症 / JCウイルス / HLA / 進行性多巣性白質脳症 / 疾患修飾薬 / 神経内科疾患 / 脱髄疾患 / 神経免疫疾患 / 慢性炎症性脱髄性多発神経根炎 / NF155 / PlexinD1 / 抗核抗体 / 自己抗体 / 遺伝環境リスク / バイオマーカー / α-シヌクレイン / グリオパチー / グリア標的治療 / 小脳型多系統萎縮症 / 進行型多発性硬化症 Less

Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channelOngoing
- Principal Investigator
  
  松下拓也
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
活性化グリア細胞制御による進行性多発性硬化症および多系統萎縮症の画期的治療法開発Ongoing
- Principal Investigator
  
  真崎勝久
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
新規同定環境リスク因子に基づいたウルチ米アミロースによる多発性硬化症の画期的治療Principal InvestigatorOngoing
- Principal Investigator
  
  渡邉充
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
日本人多発性硬化症での疾患修飾薬による進行性多巣性白質脳症多発機序の解明と防止Ongoing
- Principal Investigator
  
  河野祐治
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodiesOngoing
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expressionOngoing
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Kyushu University
Development of a new treatment for CNS demyelinating disorders targeting glucose and monocarboxylate transporterPrincipal Investigator
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Development of a novel treatment strategy based on the mechanisms that pathogenic T cells induce loss of glial connexins in CNS demyelinating disordersPrincipal Investigator
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis2020
- Author(s)
  Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J.
- Journal Title
  
  J Neurol Sci
  
  Volume: 413 Pages: 116768-116768
- DOI
  10.1016/j.jns.2020.116768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-19K21317
[Journal Article] Environmental risk factors for multiple sclerosis in Japanese people2020
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J.
- Journal Title
  
  Mult Scler Relat Disord
  
  Volume: 38 Pages: 101872-101872
- DOI
  10.1016/j.msard.2019.101872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K07995, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470
[Journal Article] Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD2019
- Author(s)
  Watanabe M, Nakamura Y, Michalak Z, Isobe N, Barro C, Leppert D, Matsushita T, Hayashi F, Yamasaki R, Kuhle J, Kira J.
- Journal Title
  
  Neurology
  
  Volume: 93
- DOI
  10.1212/wnl.0000000000008160
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470
[Journal Article] Oral phase dysphagia in facial onset sensory and motor neuronopathy.2018
- Author(s)
  Watanabe M, et al.
- Journal Title
  
  Brain Behav.
  
  Volume: 8
- DOI
  10.1002/brb3.999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19663
[Journal Article] The relationship between Th1 cells and astrocytic connexin 43 gap junctions in multiple sclerosis.2017
- Author(s)
  Watanabe M, Yamasaki R, Kira J.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19489
[Journal Article] Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation.2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 38387-38387
- DOI
  10.1038/srep38387
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-25117001, KAKENHI-PLANNED-25117012, KAKENHI-PROJECT-16H02657, KAKENHI-PROJECT-26461295, KAKENHI-PROJECT-15K15341, KAKENHI-PROJECT-15K19489
[Presentation] A novel risk molecule associated with neurological impairment identified by genome-wide association studies for neuromyelitis optica.2019
- Author(s)
  Takuya Matsushita, Katsuhisa Masaki, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  The 6th MS Summer College in Fukuoka. 2019.8.3. Fukuoka, Japan.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症発症リスクにHLAアリル多型が関与する2019
- Author(s)
  渡邉充、中村優理、磯部紀子、田中正美、松下拓也、河野祐治、迫田礼子、林史恵、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 日本人における視神経脊髄炎の環境要因についての検討2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genome-wide association studies for neuromyelitis optica and the clinical phenotypes.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Ayako Sakoda, Takuya Matsushita, Yuri Nakamura, Mitsuru Watanabe, Koji Shinoda, Noriko Isobe, Jun-ichi Kira
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.24. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Genetic studies on Japanese multiple sclerosis and neuromyelitis optica spectrum disorders.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 米食の予防効果は多発性硬化症でみられるが視神経脊髄炎関連疾患ではみられない2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第37回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Effect of HLA class II alleles on JCV infection in Japanese patients with multiple sclerosis2019
- Author(s)
  Watanabe M, Nakamura Y, Isobe N, Tanaka M, Sakoda A, Hayashi F, Matsushita T, Kira J.
- Organizer
  35th Congress of ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Isobe N, Kira J.
- Organizer
  60th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 血清GFAPとニューロフィラメント軽鎖は視神経脊髄炎関連疾患や多発性硬化症の障害度や再発率と相関する2018
- Author(s)
  渡邉　充ら
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in neuromyelitis optica spectrum disorders2018
- Author(s)
  Watanabe M, et al.
- Organizer
  ECTRIMS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as potential biomarkers for disease activity and disability in neuromyelitis optica spectrum disorders and multiple sclerosis2018
- Author(s)
  Watanabe M, et al.
- Organizer
  PACTRIMS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16124
[Presentation] IFN-gamma inhibit the expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Suzumura A, Kira J
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸市（神戸コンベンションセンター）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFN-gamma inhibit the expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  渡邉　充
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFNγはミクログリアにIL-1β/TNFαを産生させてアストロサイトコネキシン43発現を低下させる2016
- Author(s)
  渡邉充、眞﨑勝久、山﨑亮、川ノ口潤、竹内英之、錫村明生、吉良潤一
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎（長崎ブリックホール）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] IFNγ reduces expression of connexin43 in astrocytes via activation of microglia2016
- Author(s)
  Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Suzumura A, Kira J
- Organizer
  32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  ロンドン (ExCeL London)
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1 cells inhibit the expression of connexins in astrocytes2015
- Author(s)
  Mitsuru Watanabe
- Organizer
  31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1 cells inhibit the expression of connexins in astrocytes2015
- Author(s)
  渡邉　充
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K19489
[Presentation] Th1細胞によるアストロサイトのコネキシン発現抑制作用2015
- Author(s)
  渡邉　充
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  岐阜
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-15K19489

1. Kira Jun-ichi (40183305)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
2. 松下拓也 (00533001)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
3. 山崎亮 (10467946)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. 磯部紀子 (60452752)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. 山口浩雄 (00701830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 真崎勝久 (90612903)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. 中村優理 (40822375)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
8. 松瀬大 (70596395)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 篠田紘司 (70747998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 河野祐治 (20333479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤井敬之 (30822481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 緒方英紀 (90778838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 萬谷博 (20321870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 海田賢一 (40531190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 立川正憲 (00401810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMASAKI Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
17. MASAKI Katsuhisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. SUZUMURA Akio

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. TAKEUCHI Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. KAWANOKUCHI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Watanabe Mitsuru 渡邉 充

Research Projects

Research Products

Co-Researchers

Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channelOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

活性化グリア細胞制御による進行性多発性硬化症および多系統萎縮症の画期的治療法開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規同定環境リスク因子に基づいたウルチ米アミロースによる多発性硬化症の画期的治療Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

日本人多発性硬化症での疾患修飾薬による進行性多巣性白質脳症多発機序の解明と防止Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodiesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expressionOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new treatment for CNS demyelinating disorders targeting glucose and monocarboxylate transporterPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel treatment strategy based on the mechanisms that pathogenic T cells induce loss of glial connexins in CNS demyelinating disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental risk factors for multiple sclerosis in Japanese people2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral phase dysphagia in facial onset sensory and motor neuronopathy.2018

Watanabe Mitsuru 渡邉充