Yoshioka Hiroki 吉岡弘毅

… Alternative Names

YOSHIOKA HIROKI 吉岡弘毅

吉岡弘毅ヨシオカヒロキ

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Researcher Number	30756606
Other IDs	https://orcid.org/0000-0002-0977-434X
Affiliation (Current)	2025: 北里大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 北里大学, 医学部, 准教授 2022 – 2024: 岐阜医療科学大学, 薬学部, 講師 2023: 岐阜医療科学大学, 薬学部薬学科, 講師 2022: 金城学院大学, 薬学部, 助教 2020 – 2022: 岐阜医療科学大学, 保健科学部, 研究員 2017 – 2018: 金城学院大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 58010:Medical management and medical sociology-related / Risk sciences of radiation and chemicals
Keywords	Principal Investigator 時間毒性 / 重金属 / シスプラチン / 時間薬理 Except Principal Investigator 糖鎖代謝 / N-glycan / 遊離N-glycan / 骨免疫 / 薬剤関連顎骨壊死 / 細胞外小胞 … More / ゴルジ体ストレス / 時空間解析 / 代謝フラックス / in vivoイメージング / 胚発生 / ゲノム毒性 / 精子 / 小児がんサバイバー / 歯髄幹細胞 / シェーグレン症候群 / ヘルパーT細胞 / 抗炎症作用 / エクソソーム / iPS細胞 / シフトワーカー / 生体リズム / 糖尿病患者 / 交替勤務者 / 血糖トレンド値 / 血糖管理 / 概日リズム / 血糖降下剤 / 糖尿病 / 交替制勤務 / 衛生 / 肝障害 / 酸化チタン / トキシコロジー / 精巣毒性 / 二酸化チタンナノ粒子 / IVF法 / チタンナノ粒子 / 精子運動能 / 精巣機能 / ナノ粒子 / 二酸化チタン / 2-フルオロフコース / 1-デオキシマンノジリマイシン / キフネシン / スワインソニン / 遊離オリゴ糖 / 複合糖質 / ケミカルグライコミクス / ブレフェルディンA / 阻害剤 / グライコミクス / 細胞内動態 / 定性・定量解析 / パウチマンノース型 / モノアンテナ型 / ハイブリッド型 Less

骨免疫に着目した細胞外小胞による薬剤関連顎骨壊死の新規治療法の開発
- Principal Investigator
  
  緒方謙一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Involvement of clock genes against metal-induced diurnal toxicityPrincipal Investigator
- Principal Investigator
  
  吉岡弘毅
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kitasato University
Studying on contributing to ensuring fertility and avoiding developmental toxicity risks in paediatric cancer patients
- Principal Investigator
  
  横田理
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Institute of Health Sciences
ゴルジ体の機能阻害が誘導する遊離および結合型N-glycanの代謝フラックスの時空間解析
- Principal Investigator
  
  篠原康郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kinjo Gakuin University
iPS細胞のエクソソームを用いたT細胞制御による自己免疫疾患の新規治療法開発
- Principal Investigator
  
  緒方謙一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
diurnal variation of cisplatin-induced anti-tumor effect and renal toxicityPrincipal Investigator
- Principal Investigator
  
  YOSHIOKA HIROKI
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gihu University of Medical Science
Basic and clinical research aiming at optimization of blood sugar management for shift workers
- Principal Investigator
  
  吉川昌江
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Kinjo Gakuin University
Comprehensive analysis of glycan metabolic networks by chemical glycomic approach
- Principal Investigator
  
  Shinohara Yasuro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kinjo Gakuin University
Molecular mechanism of testicular dysfunction induced by titanium dioxide nanoparticles
- Principal Investigator
  
  Miura Nobuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Occupational Safety and Health,Japan

All 2024 2023 2022 2021 2019 2017

All Journal Article Presentation

[Journal Article] Extracellular vesicles of iPS cells highly capable of producing HGF and TGF-β1 can attenuate Sj?gren's syndrome via innate immunity regulation2024
- Author(s)
  Ogata Kenichi、Moriyama Masafumi、Kawado Tatsuya、Yoshioka Hiroki、Yano Aiko、Matsumura-Kawashima Mayu、Nakamura Seiji、Kawano Shintaro
- Journal Title
  
  Cellular Signalling
  
  Volume: 113 Pages: 110980-110980
- DOI
  10.1016/j.cellsig.2023.110980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18401, KAKENHI-PROJECT-22K19631, KAKENHI-PROJECT-21K10075, KAKENHI-PROJECT-22K10221
[Journal Article] Let-7c-5p associate with inhibition of phenobarbital-induced cell proliferation in human palate cells2024
- Author(s)
  Tsukiboshi Yosuke、Noguchi Azumi、Horita Hanane、Mikami Yurie、Yokota Satoshi、Ogata Kenichi、Yoshioka Hiroki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 696 Pages: 149516-149516
- DOI
  10.1016/j.bbrc.2024.149516
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10221
[Journal Article] Involvement of microRNA-4680-3p against phenytoin-induced cell proliferation inhibition in human palate cells2024
- Author(s)
 Yosuke Tsukiboshi , Hanane Horita , Yurie Mikami , Azumi Noguchi , Satoshi Yokota , Kenichi Ogata , Hiroki Yoshioka
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 49 Issue: 1 Pages: 1-8
- DOI
 10.2131/jts.49.1
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-19K19235, KAKENHI-PROJECT-22K10221
[Journal Article] Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells2023
- Author(s)
  Sugiura Kanako、Kawai Yuho、Yamamoto Arisa、Yoshioka Hiroki、Kiyohara Yuika、Iida Ayaka、Ozawa Yurika、Nishikawa Mai、Miura Nobuaki、Hanamatsu Hisatoshi、Furukawa Jun-ichi、Shinohara Yasuro
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1867 Issue: 5 Pages: 130331-130331
- DOI
  10.1016/j.bbagen.2023.130331
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12124, KAKENHI-PROJECT-18H02565, KAKENHI-PROJECT-23K24759
[Journal Article] Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice2023
- Author(s)
 Sarah Tominaga, Hiroki Yoshioka, Satoshi Yokota, Yosuke Tsukiboshi, Masumi Suzui, Makoto Nagai, Hirokazu Hara, Tohru Maeda, Nobuhiko Miura
- Journal Title
 
 Environ Health Prev Med
 
 Volume: 28 Issue: 0 Pages: 78-78
- DOI
 10.1265/ehpm.23-00205
- ISSN
 1342-078X, 1347-4715
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K15328
[Journal Article] Involvement of Bmal1 and Clock in Bromobenzene Metabolite-Induced Diurnal Renal Toxicity2023
- Author(s)
 Yoshioka Hiroki、Yokota Satoshi、Tominaga Sarah、Tsukiboshi Yosuke、Suzui Masumi、Shinohara Yasuro、Yoshikawa Masae、Sasaki Hayato、Sasaki Nobuya、Maeda Tohru、Miura Nobuhiko
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 46 Issue: 6 Pages: 824-829
- DOI
 10.1248/bpb.b23-00072
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2023-06-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K10416, KAKENHI-PROJECT-23K05603, KAKENHI-PROJECT-22K15328
[Journal Article] Evaluation of the context of downstream N- and free N-glycomic alterations induced by swainsonine in HepG2 cells2022
- Author(s)
  Morikawa Chie、Sugiura Kanako、Kondo Keina、Yamamoto Yurie、Kojima Yuma、Ozawa Yurika、Yoshioka Hiroki、Miura Nobuaki、Piao Jinhua、Okada Kazue、Hanamatsu Hisatoshi、Tsuda Masumi、Tanaka Shinya、Furukawa Jun-ichi、Shinohara Yasuro
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1866 Issue: 9 Pages: 130168-130168
- DOI
  10.1016/j.bbagen.2022.130168
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12124, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H03802, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-18H02565
[Journal Article] Impaired GATE16-mediated exocytosis in exocrine tissues causes Sj?gren’s syndrome-like exocrinopathy2022
- Author(s)
  Suzuki Akiko、Iwaya Chihiro、Ogata Kenichi、Yoshioka Hiroki、Shim Junbo、Tanida Isei、Komatsu Masaaki、Tada Norihiro、Iwata Junichi
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 79 Issue: 6 Pages: 307-307
- DOI
  10.1007/s00018-022-04334-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10221, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-18K05691, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PUBLICLY-22H04652
[Journal Article] Different Renal Chronotoxicity of Bromobenzene and Its Intermediate Metabolites in Mice2021
- Author(s)
  Yoshioka Hiroki、Tominaga Sarah、Nishikawa Mai、Shinohara Yasuro、Nakao Makoto、Yoshikawa Masae、Maeda Tohru、Miura Nobuhiko
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 1 Pages: 150-153
- DOI
  10.1248/bpb.b20-00694
- NAID
  130007965324
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-01-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K10416
[Journal Article] Impairment of fertilization efficiency in mice following nano-sized titanium exposure2019
- Author(s)
  Nobuhiko Miura, Katsumi Ohtani, Tatsuya Hasegawa, Gi-Wook Hwang, Hiroki Yoshioka
- Journal Title
  
  Fund Toxicol Sci
  
  Volume: 6 Pages: 113-116
- NAID
  130007649489
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02829
[Journal Article] Biphasic adverse effect of titanium nanoparticles on testicular function in mice2019
- Author(s)
  Nobuhiko Miura, Katsumi Ohtani, Tatsuya Hasegawa, Hiroki Yoshioka & Gi-Wook Hwang
- Journal Title
  
  Scientific Report
  
  Volume: 9 Issue: 1 Pages: 14373-14380
- DOI
  10.1038/s41598-019-50741-9
- Open Access
- Data Source
  KAKENHI-PROJECT-15H02829
[Journal Article] High sensitivity of testicular function to titanium nanoparticles2017
- Author(s)
  Nobuhiko Miura, Katsumi Ohtani, Tatsuya Hasegawa, Hiroki Yoshioka, Gi-Wook Hwang
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 3 Pages: 359-366
- DOI
  10.2131/jts.42.359
- NAID
  130006865652
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02829
[Presentation] 歯髄幹細胞由来の細胞外小胞を付加した人工神経を使った新たな末梢神経再生療法の開発2024
- Author(s)
  緒方　謙一、矢野　亜衣子、森山　雅文、吉岡　弘毅、川戸　達也、川野　真太郎
- Organizer
  第23回　日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K10221
[Presentation] α-グルコシダーゼ阻害剤がHepG2細胞のN-グリカン、遊離オリゴ糖、スフィンゴ糖脂質の発現に与える影響2024
- Author(s)
  廣瀬郁実、田中志歩、榊原真帆、田上明里、渡邊真里菜、吉岡弘毅、篠原康郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06087
[Presentation] ゴルジ体ストレス誘導剤のBrefeldin AとGolgicide AがHepG2細胞のN-glycan, 遊離N-glycanの代謝に与える影響2024
- Author(s)
  加田真彩、寺川実那、廣瀬郁実、田中志歩、清原由衣可、杉浦花菜子、川合裕穂、山本有紗、吉岡弘毅、篠原康郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06087
[Presentation] MonensinやNigericinはHepG2細胞においてモノアンテナ型やコンプレックス型の遊離N-グリカンの発現を誘導する2024
- Author(s)
  西村音々、廣瀬郁実、田中志歩、渡邊真里菜、清原由衣可、杉浦花菜子、山本有紗、川合裕穂、吉岡弘毅、篠原康郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06087
[Presentation] シスプラチンの感受性時刻差における抗腫瘍作用と腎障害の統合評価2024
- Author(s)
  吉岡弘毅、三上友理恵、松下幸平、横田理、富永サラ、前田徹、三浦伸彦
- Organizer
  日本薬学会第144年会（横浜）
- Data Source
  KAKENHI-PROJECT-22K15328
[Presentation] シスプラチンによる急性腎毒性と時計遺伝子の関与2023
- Author(s)
  吉岡弘毅
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-22K15328
[Presentation] シスプラチンによる腎障害に対する時計遺伝子発現変化の影響2023
- Author(s)
  吉岡弘毅、富永サラ、横田理、前田徹、三浦伸彦
- Organizer
  第六回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-22K15328
[Presentation] シスプラチンによる急性腎障害の感受性時刻差に関与する因子の探索2023
- Author(s)
  富永サラ、吉岡弘毅、杉本昌弘、三浦伸彦、前田徹
- Organizer
  第94回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15328
[Presentation] Brefeldin AはHepG2細胞においてユニークなハイブリッド型やコンプレックス型の遊離N-glycanの発現を誘導する2023
- Author(s)
  清原由衣可、杉浦花菜子、川合裕穂、山本有紗、飯田彩華、小澤優里香、吉岡弘毅、篠原康郎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-18H02565
[Presentation] Titanium dioxide nanopaticles-induced testicular dysfunction is mediated by anatase titanium dioxide2019
- Author(s)
  Hiroki Yoshioka, Nobuhiko Miura
- Organizer
  フォーラム2018 衛生薬学・環境トキシコロジー日韓次世代シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02829
[Presentation] 酸化チタンナノ粒子による急性精巣機能障害の誘発機構2019
- Author(s)
  三浦伸彦，田中廣輝，北條理恵子，大谷勝己，吉岡弘毅
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H02829
[Presentation] 酸化チタンナノ粒子による精巣障害および肝障害の比較2017
- Author(s)
  三浦伸彦，北條理恵子，吉岡弘毅，大谷勝己
- Organizer
  生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-15H02829
[Presentation] マウスにおける酸化チタンの雄性生殖系への影響2017
- Author(s)
  大谷勝己，北條理恵子，吉岡弘毅，三浦伸彦
- Organizer
  生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-15H02829

1. Shinohara Yasuro (20374192)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. Miura Nobuhiko (20229644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 緒方謙一 (30778858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 森山雅文 (20452774)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 古川潤一 (30374193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大谷勝己 (50333373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉川昌江 (80581389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中村誠司 (60189040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 横田理 (70706605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐藤卓也 (70599505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鹿島誠 (10780562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 宮宗秀伸 (80422252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 川野真太郎 (00398067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 堀口兵剛 (90254002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OHTANI Katsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
16. 三浦信明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yoshioka Hiroki 吉岡 弘毅

YOSHIOKA HIROKI 吉岡 弘毅

吉岡 弘毅 ヨシオカ ヒロキ

Research Projects

Research Products

Co-Researchers

骨免疫に着目した細胞外小胞による薬剤関連顎骨壊死の新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of clock genes against metal-induced diurnal toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studying on contributing to ensuring fertility and avoiding developmental toxicity risks in paediatric cancer patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ゴルジ体の機能阻害が誘導する遊離および結合型N-glycanの代謝フラックスの時空間解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPS細胞のエクソソームを用いたT細胞制御による自己免疫疾患の新規治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

diurnal variation of cisplatin-induced anti-tumor effect and renal toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic and clinical research aiming at optimization of blood sugar management for shift workers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of glycan metabolic networks by chemical glycomic approach

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of testicular dysfunction induced by titanium dioxide nanoparticles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Extracellular vesicles of iPS cells highly capable of producing HGF and TGF-β1 can attenuate Sj?gren's syndrome via innate immunity regulation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Let-7c-5p associate with inhibition of phenobarbital-induced cell proliferation in human palate cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of <i>microRNA-4680-3p</i> against phenytoin-induced cell proliferation inhibition in human palate cells2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Exposure to brefeldin A induces unusual expression of hybrid- and complex-type free N-glycans in HepG2 cells2023

Author(s)

Journal Title

Yoshioka Hiroki 吉岡弘毅

YOSHIOKA HIROKI 吉岡弘毅

吉岡弘毅ヨシオカヒロキ