Morinaga Takao 盛永敬郎

Researcher Number	30757000
Affiliation (Current)	2022: 千葉県がんセンター(研究所), がん治療開発グループ細胞治療開発研究部, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 千葉県がんセンター(研究所), がん治療開発グループ細胞治療開発研究部, 研究員 2020 – 2021: 千葉県がんセンター(研究所), がん治療開発グループがん先進治療開発研究室, 研究員 2016 – 2019: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Biological pharmacy / Basic Section 53030:Respiratory medicine-related / Basic Section 53050:Dermatology-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 悪性中皮腫 / 遺伝子治療 / アデノウイルス / 細胞周期 / p53 / チロシンキナーゼ / adenovirus / wee1 / apoptosis / replication … More / cell cycle / Wee1 キナーゼ / 細胞障害活性 / アポトーシス / 癌 / ウイルス / シグナル伝達 / 腫瘍融解性アデノウイルス / がん代謝 / 脂質合成酵素 / 代謝 / 免疫チェックポイント / 細胞接着 / 免疫疲弊 / 抗腫瘍活性 … More Except Principal Investigator 腫瘍免疫 / PD-1 / がん抗原 / 肺癌 / ネオ抗原 Less

悪性黒色腫の腫瘍特異的疲弊T細胞に発現する新規接着因子の機能解析と臨床応用Principal Investigator
- Principal Investigator
  
  盛永敬郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Analysis of PD-1+ tumor-infiltrating T cells according to cancer antigen hierarchy
- Principal Investigator
  
  冨樫庸介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
  Chiba Cancer Center (Research Institute)
The therapeutic strategies with augmented replications of oncolytic adenoviruses for malignant mesotheliomaPrincipal Investigator
- Principal Investigator
  
  MORINAGA Takao
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba Cancer Center (Research Institute)
An effect of the combination of oncolytic adenoviruses and a tyrosine-kinase inhibitor.Principal Investigator
- Principal Investigator
  
  Morinaga Takao
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
  Biological pharmacy
- Research Institution
  Chiba Cancer Center (Research Institute)

All 2022 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T?cell clonotypes2022
- Author(s)
  Nagasaki Joji、Inozume Takashi、Yosuke Togashi et al.
- Journal Title
  
  Cell reports
  
  Volume: 38 Pages: 110331-110331
- DOI
  10.1016/j.celrep.2022.110331
- NAID
  120007192058
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K08152, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-21K12117
[Journal Article] AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.2019
- Author(s)
  Qin, Y. Sekine, I. Hanazono, M. Morinaga, T. Fan, M. Takiguchi, Y. Tada, Y. Shingyoji, M. Yamaguchi, N. Tagawa, M.
- Journal Title
  
  Mol Oncol.
  
  Volume: 13 Pages: 1419-1432
- DOI
  10.1002/1878-0261.12496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09647, KAKENHI-PROJECT-18K15937
[Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway2019
- Author(s)
  Zhong, B., Shingyoji, M., Hanazono, M., Nguyen, T.T.T., Morinaga, T., Tada, Y., Hiroshima, K., Shimada, H., Tagawa, M.
- Journal Title
  
  Am. J. Cancer Res.
  
  Volume: 9 Pages: 79-93
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15937
[Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway.2019
- Author(s)
  Boya Zhong, Masato Shingyoji, Michiko Hanazono, Thao Thi Thanh Nguyen, Takao Morinaga, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa
- Journal Title
  
  Am. J. Cancer Res.
  
  Volume: 9 Pages: 79-93
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15937
[Journal Article] Heat shock protein 90 inhibitors augmented endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity2018
- Author(s)
  Ushigome Mitsunori、Nabeya Yoshihiro、Soda Hiroaki、Takiguchi Nobuhiro、Kuwajima Akiko、Tagawa Masatoshi、Matsushita Kazuyuki、Koike Junichi、Funahashi Kimihiko、Shimada Hideaki
- Journal Title
  
  Oncotarget
  
  Volume: 23 Pages: 26130-26143
- DOI
  10.1007/s10147-018-1278-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-18K15937, KAKENHI-PROJECT-26462029
[Journal Article] Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.2018
- Author(s)
  Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
- Journal Title
  
  Int J Mo1 Sci.
  
  Volume: 19 Issue: 6 Pages: 1811-1811
- DOI
  10.3390/ijms19061811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15937, KAKENHI-PROJECT-16H06276
[Journal Article] An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced.2017
- Author(s)
  Morinaga Takao、Nguyen Thao Thi Thanh、Zhong Boya、Hanazono Michiko、Shingyoji Masato、Sekine Ikuo、Tada Yuji、Tatsumi Koichiro、Shimada Hideaki、Hiroshima Kenzo、Tagawa Masatoshi
- Journal Title
  
  Virology Journal
  
  Volume: 14 Pages: 219-219
- DOI
  10.1186/s12985-017-0888-0
- NAID
  120007128796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10617, KAKENHI-PROJECT-16K21639
[Presentation] An inhibitor for the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma2019
- Author(s)
  Takao Morinaga, Shuji Kubo, Masato Shingyoji, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  第25回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Downregulation of the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma.2019
- Author(s)
  盛永敬郎, 久保秀司, 関根郁夫, 多田裕司, 島田英昭
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Cytotoxicity of oncolytic adenoviruses against p53-deficient cells was enhanced by a wee1 kinase inhibitor.2019
- Author(s)
  Takao Morinaga, Masatoshi Tagawa
- Organizer
  APCGCT 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Wee1 阻害薬はp53欠損細胞における腫瘍融解性アデノウイルスの複製と感染を増強する2018
- Author(s)
  盛永敬郎、グエン　タオ、鐘博雅、久保秀司、関根郁夫、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] A Wee1 kinase inhibitor augments apoptosis and replications of adenoviruses in p53-deficient tumor cells2018
- Author(s)
  Takao Morinaga, Thao Thi Thanh Nguyen, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  24th annual meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Cytotoxicity of Replication-Competent Adenoviruses Defective of E1B55kDa Molecules Is Irrelevant to P53 Expression, but Increases with a P53-Augmenting MDM2 Inhibitor through DNA Damages and Enhanced Viral Propagations in Mesothelioma with the Wild-Type P53 Genotype2018
- Author(s)
  Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Yuichi Takiguchi, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  21st annual meeting of American Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] 切除不能胸膜中皮腫に対しNK4遺伝子発現アデノウィルスベクター胸腔内投与の安全性を確認する臨床試験2018
- Author(s)
  多田裕司、盛永敬郎、鈴木敏夫、下村巌、由佐俊和、島田英昭、廣島健三、滝口裕一、巽浩一郎、田川雅敏
- Organizer
  第５９回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Wee1 kinase inhibitor increased cytotoxicity of oncolytic adenoviruses in p53-deficient cells2018
- Author(s)
  T. Morinaga, N.T. Thao, Z. Boya, M. Tagawa
- Organizer
  American Society for Cell Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Inhibition of the HGF/c-Met for mesothelioma with an intra-pleural injection of the NK4 gene-expressing adenoviral vectors2018
- Author(s)
  Yuji Tada, Takao Morinaga, Ikuo Sekine, Toshio Suzuki, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  The 14th international conference of the international mesothelioma interested group
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] MDM2阻害剤による内因性p53発現上昇は、転写調節因子NF1発現を上昇させ腫瘍融解性ウイルスの増殖を増強させる2018
- Author(s)
  グエン　タオ、盛永敬郎、鐘博雅、久保秀司、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] 胸膜中皮腫を対象としたNK4遺伝子発現ベクター胸腔内投与の第1相臨床試験2018
- Author(s)
  多田裕司、盛永敬郎、鈴木敏夫、下村巌、石綿司、由佐俊和、島田英昭、廣島健三、滝口裕一、関根郁夫、巽浩一郎、田川雅敏
- Organizer
  第25回石綿・中皮腫研究会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Inhibition of the HGF/c-Met for mesothelioma with an intra-pleural injection of the NK4 gene-expressing adenoviral vectors2018
- Author(s)
  Yuji. Tada, Takao Morinaga, Ikuo Sekine, Toshio Suzuki, Iwao Shimomura, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  International Association for the Study of Lung Cancer 19th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] An MDM2 inhibitor achieves synergistic cytotoxicity with oncolytic adenoviruses on mesothelioma with the wild-type p53 gene2018
- Author(s)
  Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  The 14th international conference of the international mesothelioma interested group
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] A phase1 clinical trial of inhibiting the HGF/c-Met pathway for malignant pleural mesothelioma with NK4 gene-expressing adenoviral vectors2018
- Author(s)
  Yuji Tada, Takao Morinaga, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  24th annual meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] 核酸合成酵素非依存的なペメトレキセート耐性はAICARTを介したAMPKの活性化に関与している2018
- Author(s)
  鐘博雅、関根郁夫、滝口裕一、グエン　タオ、盛永敬郎、多田裕司、山口直人、田川雅敏
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] Inhibitors for the MDM2-p53 interaction increase a DNA damage signal and augment replications of oncolytic adenoviruses in mesothelioma with the wild-type p53 genotype2018
- Author(s)
  Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Michiko Hanazono, Masato Shingyoji, Shuji Kubo, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  24th annual meeting of Japan Society of Gene Therapy
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] HSP90阻害剤は内因性p53発現を上昇させるが外因性p53発現をプロテアソーム活性で抑制する2018
- Author(s)
  田川雅敏、盛永敬郎、鐘博雅、Nguyen Thi Thanh Thao、久保秀司、多田裕司、巽浩一郎、島田英昭、廣島健三、山口直人
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15937
[Presentation] A MDM2 inhibitor achieves synergistic cytotoxicity with oncolytic adenoviruses on mesothelioma with the wild-type p532017
- Author(s)
  Thi Thanh Thao Nguyen, Boya Zhong, Takao Morinaga, Shuji Kubo, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] A Wee1 kinase inhibitor increases apoptosis of replication-competent adenoviruses through induction of mitotic catastrophe and enhancement of viral replications2017
- Author(s)
  Takao Morinaga, Thao Thi Thanh Nguyen, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] Resistance to pemetrexed in mesothelioma is associated with up-regulated expression of AMPactivated protein kinase2017
- Author(s)
  Boya Zhong, Ikuo Sekine, Yuichi Takiguchi, Thi Thanh Thao Nguyen, Takao Morinaga, Yuji Tada, Naoto Yamaguchi, Masatoshi Tagawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] A MDM2 inhibitor augments cytotoxicity of oncolytic adenoviruses defective of E1B 55kDa molecules through enhancing DNA damages and apoptosis in mesothelioma2017
- Author(s)
  Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Michiko Hanazono, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] A role of Wee1 kinase in adenoviruses-induced cell death and viral replication.2017
- Author(s)
  Takao Morinaga, Thi Thanh Thao Nguyen, Boya Zhong, Shuji Kubo, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] 細胞周期促進は増殖性アデノウイルスによるアポトーシスを増強する2016
- Author(s)
  盛永敬郎, グエンタオ, チョンボウヤア, 久保秀司, 関根郁夫, 多田裕司, 巽浩一郎, 島田英昭, 廣島健三, 田川雅敏
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K21639
[Presentation] Cell adhesion changes the localization of Lyn tyrosine kinase2016
- Author(s)
  Takao Morinaga, Noritaka Yamaguchi, Masatoshi Tagawa, Naoto Yamaguchi
- Organizer
  The 2016 ASCB Annual Meeting
- Place of Presentation
  サンフランシスコ(アメリカ合衆国)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21639

1. 冨樫庸介 (80758326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 猪爪隆史 (80334853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. KOIKE Junichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 松下一之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 島田英昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 入江拓磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 花澤豊行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 田川雅敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morinaga Takao 盛永 敬郎

Research Projects

Research Products

Co-Researchers

悪性黒色腫の腫瘍特異的疲弊T細胞に発現する新規接着因子の機能解析と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of PD-1+ tumor-infiltrating T cells according to cancer antigen hierarchy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The therapeutic strategies with augmented replications of oncolytic adenoviruses for malignant mesotheliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An effect of the combination of oncolytic adenoviruses and a tyrosine-kinase inhibitor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T?cell clonotypes2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway2019

Author(s)

Journal Title

Data Source

[Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway.2019

Author(s)

Journal Title

Data Source

[Journal Article] Heat shock protein 90 inhibitors augmented endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] An inhibitor for the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma2019

Author(s)

Organizer

Data Source

[Presentation] Downregulation of the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma.2019

Author(s)

Organizer

Data Source

[Presentation] Cytotoxicity of oncolytic adenoviruses against p53-deficient cells was enhanced by a wee1 kinase inhibitor.2019

Author(s)

Organizer

Data Source

[Presentation] Wee1 阻害薬はp53欠損細胞における腫瘍融解性アデノウイルスの複製と感染を増強する2018

Author(s)

Organizer

Data Source

[Presentation] A Wee1 kinase inhibitor augments apoptosis and replications of adenoviruses in p53-deficient tumor cells2018

Morinaga Takao 盛永敬郎