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Morinaga Takao  盛永 敬郎

ORCIDConnect your ORCID iD *help
Researcher Number 30757000
Affiliation (Current) 2022: 千葉県がんセンター(研究所), がん治療開発グループ 細胞治療開発研究部, 研究員
Affiliation (based on the past Project Information) *help 2021 – 2022: 千葉県がんセンター(研究所), がん治療開発グループ 細胞治療開発研究部, 研究員
2020 – 2021: 千葉県がんセンター(研究所), がん治療開発グループ がん先進治療開発研究室, 研究員
2016 – 2019: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine / Biological pharmacy / Basic Section 53030:Respiratory medicine-related / Basic Section 53050:Dermatology-related
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related
Keywords
Principal Investigator
悪性中皮腫 / 遺伝子治療 / アデノウイルス / 細胞周期 / p53 / チロシンキナーゼ / adenovirus / wee1 / apoptosis / replication … More / cell cycle / Wee1 キナーゼ / 細胞障害活性 / アポトーシス / 癌 / ウイルス / シグナル伝達 / 腫瘍融解性アデノウイルス / がん代謝 / 脂質合成酵素 / 代謝 / 免疫チェックポイント / 細胞接着 / 免疫疲弊 / 抗腫瘍活性 … More
Except Principal Investigator
腫瘍免疫 / PD-1 / がん抗原 / 肺癌 / ネオ抗原 Less
  • Research Projects

    (4 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (11 People)
  •  悪性黒色腫の腫瘍特異的疲弊T細胞に発現する新規接着因子の機能解析と臨床応用Principal Investigator

    • Principal Investigator
      盛永 敬郎
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  Analysis of PD-1+ tumor-infiltrating T cells according to cancer antigen hierarchy

    • Principal Investigator
      冨樫 庸介
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Okayama University
      Chiba Cancer Center (Research Institute)
  •  The therapeutic strategies with augmented replications of oncolytic adenoviruses for malignant mesotheliomaPrincipal Investigator

    • Principal Investigator
      MORINAGA Takao
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Chiba Cancer Center (Research Institute)
  •  An effect of the combination of oncolytic adenoviruses and a tyrosine-kinase inhibitor.Principal Investigator

    • Principal Investigator
      Morinaga Takao
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
      Biological pharmacy
    • Research Institution
      Chiba Cancer Center (Research Institute)

All 2022 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T?cell clonotypes2022

    • Author(s)
      Nagasaki Joji、Inozume Takashi、Yosuke Togashi et al.
    • Journal Title

      Cell reports

      Volume: 38 Pages: 110331-110331

    • DOI

      10.1016/j.celrep.2022.110331

    • NAID

      120007192058

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K08152, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-21K12117
  • [Journal Article] AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.2019

    • Author(s)
      Qin, Y. Sekine, I. Hanazono, M. Morinaga, T. Fan, M. Takiguchi, Y. Tada, Y. Shingyoji, M. Yamaguchi, N. Tagawa, M.
    • Journal Title

      Mol Oncol.

      Volume: 13 Pages: 1419-1432

    • DOI

      10.1002/1878-0261.12496

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09647, KAKENHI-PROJECT-18K15937
  • [Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway2019

    • Author(s)
      Zhong, B., Shingyoji, M., Hanazono, M., Nguyen, T.T.T., Morinaga, T., Tada, Y., Hiroshima, K., Shimada, H., Tagawa, M.
    • Journal Title

      Am. J. Cancer Res.

      Volume: 9 Pages: 79-93

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Journal Article] A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway.2019

    • Author(s)
      Boya Zhong, Masato Shingyoji, Michiko Hanazono, Thao Thi Thanh Nguyen, Takao Morinaga, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa
    • Journal Title

      Am. J. Cancer Res.

      Volume: 9 Pages: 79-93

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Journal Article] Heat shock protein 90 inhibitors augmented endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity2018

    • Author(s)
      Ushigome Mitsunori、Nabeya Yoshihiro、Soda Hiroaki、Takiguchi Nobuhiro、Kuwajima Akiko、Tagawa Masatoshi、Matsushita Kazuyuki、Koike Junichi、Funahashi Kimihiko、Shimada Hideaki
    • Journal Title

      Oncotarget

      Volume: 23 Pages: 26130-26143

    • DOI

      10.1007/s10147-018-1278-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-18K15937, KAKENHI-PROJECT-26462029
  • [Journal Article] Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.2018

    • Author(s)
      Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
    • Journal Title

      Int J Mo1 Sci.

      Volume: 19 Issue: 6 Pages: 1811-1811

    • DOI

      10.3390/ijms19061811

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15937, KAKENHI-PROJECT-16H06276
  • [Journal Article] An image cytometric technique is a concise method to detect adenoviruses and host cell proteins and to monitor the infection and cellular responses induced.2017

    • Author(s)
      Morinaga Takao、Nguyen Thao Thi Thanh、Zhong Boya、Hanazono Michiko、Shingyoji Masato、Sekine Ikuo、Tada Yuji、Tatsumi Koichiro、Shimada Hideaki、Hiroshima Kenzo、Tagawa Masatoshi
    • Journal Title

      Virology Journal

      Volume: 14 Pages: 219-219

    • DOI

      10.1186/s12985-017-0888-0

    • NAID

      120007128796

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10617, KAKENHI-PROJECT-16K21639
  • [Presentation] An inhibitor for the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma2019

    • Author(s)
      Takao Morinaga, Shuji Kubo, Masato Shingyoji, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      第25回 日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Downregulation of the lipid synthetic pathway increased oncolytic adenoviral replications in mesothelioma.2019

    • Author(s)
      盛永 敬郎, 久保 秀司, 関根 郁夫, 多田 裕司, 島田 英昭
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Cytotoxicity of oncolytic adenoviruses against p53-deficient cells was enhanced by a wee1 kinase inhibitor.2019

    • Author(s)
      Takao Morinaga, Masatoshi Tagawa
    • Organizer
      APCGCT 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Wee1 阻害薬はp53欠損細胞における腫瘍融解性アデノウイルスの複製と感染を増強する2018

    • Author(s)
      盛永敬郎、グエン タオ、鐘博雅、久保秀司、関根郁夫、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] A Wee1 kinase inhibitor augments apoptosis and replications of adenoviruses in p53-deficient tumor cells2018

    • Author(s)
      Takao Morinaga, Thao Thi Thanh Nguyen, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      24th annual meeting of Japan Society of Gene Therapy
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Cytotoxicity of Replication-Competent Adenoviruses Defective of E1B55kDa Molecules Is Irrelevant to P53 Expression, but Increases with a P53-Augmenting MDM2 Inhibitor through DNA Damages and Enhanced Viral Propagations in Mesothelioma with the Wild-Type P53 Genotype2018

    • Author(s)
      Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Yuichi Takiguchi, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      21st annual meeting of American Society of Gene and Cell Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] 切除不能胸膜中皮腫に対しNK4遺伝子発現アデノウィルスベクター胸腔内投与の安全性を確認する臨床試験2018

    • Author(s)
      多田裕司、盛永敬郎、鈴木敏夫、下村巌、由佐俊和、島田英昭、廣島健三、滝口裕一、巽浩一郎、田川雅敏
    • Organizer
      第59回日本肺癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Wee1 kinase inhibitor increased cytotoxicity of oncolytic adenoviruses in p53-deficient cells2018

    • Author(s)
      T. Morinaga, N.T. Thao, Z. Boya, M. Tagawa
    • Organizer
      American Society for Cell Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Inhibition of the HGF/c-Met for mesothelioma with an intra-pleural injection of the NK4 gene-expressing adenoviral vectors2018

    • Author(s)
      Yuji Tada, Takao Morinaga, Ikuo Sekine, Toshio Suzuki, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      The 14th international conference of the international mesothelioma interested group
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] MDM2阻害剤による内因性p53発現上昇は、転写調節因子NF1発現を上昇させ腫瘍融解性ウイルスの増殖を増強させる2018

    • Author(s)
      グエン タオ、盛永敬郎、鐘博雅、久保秀司、多田裕司、巽浩一郎、島田英昭、廣島健三、田川雅敏
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] 胸膜中皮腫を対象としたNK4遺伝子発現ベクター胸腔内投与の第1相臨床試験2018

    • Author(s)
      多田裕司、盛永敬郎、鈴木敏夫、下村巌、石綿司、由佐俊和、島田英昭、廣島健三、滝口裕一、関根郁夫、巽浩一郎、田川雅敏
    • Organizer
      第25回石綿・中皮腫研究会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Inhibition of the HGF/c-Met for mesothelioma with an intra-pleural injection of the NK4 gene-expressing adenoviral vectors2018

    • Author(s)
      Yuji. Tada, Takao Morinaga, Ikuo Sekine, Toshio Suzuki, Iwao Shimomura, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      International Association for the Study of Lung Cancer 19th World Conference on Lung Cancer
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] An MDM2 inhibitor achieves synergistic cytotoxicity with oncolytic adenoviruses on mesothelioma with the wild-type p53 gene2018

    • Author(s)
      Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
    • Organizer
      The 14th international conference of the international mesothelioma interested group
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] A phase1 clinical trial of inhibiting the HGF/c-Met pathway for malignant pleural mesothelioma with NK4 gene-expressing adenoviral vectors2018

    • Author(s)
      Yuji Tada, Takao Morinaga, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      24th annual meeting of Japan Society of Gene Therapy
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] 核酸合成酵素非依存的なペメトレキセート耐性はAICARTを介したAMPKの活性化に関与している2018

    • Author(s)
      鐘博雅、関根郁夫、滝口裕一、グエン タオ、盛永敬郎、多田裕司、山口直人、田川雅敏
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] Inhibitors for the MDM2-p53 interaction increase a DNA damage signal and augment replications of oncolytic adenoviruses in mesothelioma with the wild-type p53 genotype2018

    • Author(s)
      Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Michiko Hanazono, Masato Shingyoji, Shuji Kubo, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
    • Organizer
      24th annual meeting of Japan Society of Gene Therapy
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] HSP90阻害剤は内因性p53発現を上昇させるが外因性p53発現をプロテアソーム活性で抑制する2018

    • Author(s)
      田川雅敏、盛永敬郎、鐘博雅、Nguyen Thi Thanh Thao、久保秀司、多田裕司、巽浩一郎、島田英昭、廣島健三、山口直人
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K15937
  • [Presentation] A MDM2 inhibitor achieves synergistic cytotoxicity with oncolytic adenoviruses on mesothelioma with the wild-type p532017

    • Author(s)
      Thi Thanh Thao Nguyen, Boya Zhong, Takao Morinaga, Shuji Kubo, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] A Wee1 kinase inhibitor increases apoptosis of replication-competent adenoviruses through induction of mitotic catastrophe and enhancement of viral replications2017

    • Author(s)
      Takao Morinaga, Thao Thi Thanh Nguyen, Boya Zhong, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] Resistance to pemetrexed in mesothelioma is associated with up-regulated expression of AMPactivated protein kinase2017

    • Author(s)
      Boya Zhong, Ikuo Sekine, Yuichi Takiguchi, Thi Thanh Thao Nguyen, Takao Morinaga, Yuji Tada, Naoto Yamaguchi, Masatoshi Tagawa
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] A MDM2 inhibitor augments cytotoxicity of oncolytic adenoviruses defective of E1B 55kDa molecules through enhancing DNA damages and apoptosis in mesothelioma2017

    • Author(s)
      Masatoshi Tagawa, Thao Thi Thanh Nguyen, Takao Morinaga, Boya Zhong, Michiko Hanazono, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] A role of Wee1 kinase in adenoviruses-induced cell death and viral replication.2017

    • Author(s)
      Takao Morinaga, Thi Thanh Thao Nguyen, Boya Zhong, Shuji Kubo, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] 細胞周期促進は増殖性アデノウイルスによるアポトーシスを増強する2016

    • Author(s)
      盛永敬郎, グエンタオ, チョンボウヤア, 久保秀司, 関根郁夫, 多田裕司, 巽浩一郎, 島田英昭, 廣島健三, 田川雅敏
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K21639
  • [Presentation] Cell adhesion changes the localization of Lyn tyrosine kinase2016

    • Author(s)
      Takao Morinaga, Noritaka Yamaguchi, Masatoshi Tagawa, Naoto Yamaguchi
    • Organizer
      The 2016 ASCB Annual Meeting
    • Place of Presentation
      サンフランシスコ(アメリカ合衆国)
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21639
  • 1.  冨樫 庸介 (80758326)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  猪爪 隆史 (80334853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  KOIKE Junichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  TAKIGUCHI Yuuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  松下 一之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  島田 英昭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  西川 博嘉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  入江 拓磨
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  花澤 豊行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  上野 敏秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  田川 雅敏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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