Kobayashi Isao 小林功

Researcher Number	30774757
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 生命理工学系, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 金沢大学, 生命理工学系, 准教授 2018 – 2019: 金沢大学, 生命理工学系, 助教 2017: 金沢大学, 自然システム学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Integrative animal science Except Principal Investigator Basic Section 40040:Aquatic life science-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 38060:Applied molecular and cellular biology-related / Basic Section 44040:Morphology and anatomical structure-related / Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related / Complex Systems Disease Theory
Keywords	Principal Investigator ゼブラフィッシュ / 造血幹細胞 / 発生 / インテグリン / 血管芽細胞 / 自己複製能 / 細胞間相互作用 / シグナル伝達 / 分化 / 血管内皮細胞 / 血液 / 細胞接着分子 … More Except Principal Investigator … More メラトニン / 骨代謝 / ウロコ / ゼブラフィッシュ / 代理親魚技術 / 魚類養殖 / ニッチ細胞 / Notch signaling / GFP / 蛍光免疫染色 / 繁殖補助技術 / 細胞移植 / 魚類 / ニッチ / X線照射 / 生殖幹細胞移植 / 卵巣 / 精巣 / 移植 / 生殖幹細胞 / 糖尿病 / キンギョのウロコ / 食品 / 高血糖 / 追いつき成長 / 幹細胞 / 神経堤細胞 / 体成長 / カルシトニン遺伝子の機能阻害 / カルシトニンの機能阻害 / カルシトニン / 破骨細胞 / 骨芽細胞 / ラットの頭蓋骨 / 魚類のウロコ / カップリング因子 / 骨折モデル / 比較生理学 / トランスクリプトーム解析 / 細胞外小胞 / 破骨細胞分化 / 蛍光タンパク / 遺伝子組み換えゼブラフィッシュ / 骨修復過程 / アミノ酸 / 脊椎側弯症 Less

造血幹細胞の自己複製におけるCD74の役割と制御機構Principal Investigator
- Principal Investigator
  
  小林功
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kanazawa University
Role of transcription factor Tfcp2l1 in growth spurt phenomena in zebrafish
- Principal Investigator
  
  亀井宏泰
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Kanazawa University
Study on prevention of bone disease using fish induced hyperglycemia: Effect of food containing melatonin.
- Principal Investigator
  
  鈴木信雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kanazawa University
Identification of niche cells for supporting colonization, proliferation, and differentiation of xenogenic donor germ cells in recipient gonads.
- Principal Investigator
  
  Takeuchi Yutaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  Kanazawa University
Regulatory mechanism of osteoclasts by hormones produced in osteoblasts: analysis using fish scales as a bone model
- Principal Investigator
  
  Suzuki Nobuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44040:Morphology and anatomical structure-related
- Research Institution
  Kanazawa University
Elucidation of the integrin-dependent signaling pathway in hematopoietic stem cell development.Principal Investigator
- Principal Investigator
  
  Kobayashi Isao
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Kanazawa University
Identification of novel coupling factors produced by osteoclasts and clarification of their secretory phase
- Principal Investigator
  
  北村敬一郎
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Kanazawa University
Establishment of a research platform for developing radical treatment and early predictive diagnostics for scoliosis through nutritional environmental signals
- Principal Investigator
  
  Eiichi Hinoi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Gifu Pharmaceutical University
  Kanazawa University
Dynamic analysis of hematopoietic stem cell development in the dorsal aortaPrincipal Investigator
- Principal Investigator
  
  Kobayashi Isao
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Integrative animal science
- Research Institution
  Kanazawa University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Melatonin is more effective on bone metabolism when given at early night than during the day in ovariectomized rats2023
- Author(s)
  Miki Yukari、Seki Azusa、Mishima Hiroyuki、Maruyama Yusuke、Watanabe Kazuki、Kobayashi-Sun Jingjing、Kobayashi Isao、Kuroda Kohei、Oshima Shion、Okamoto Takeru、Matsubara Hajime、Srivastav Ajai K .、Tabuchi Yoshiaki、Hirayama Jun、Hattori Atsuhiko、Suzuki Nobuo
- Journal Title
  
  Melatonin Research
  
  Volume: 6 Issue: 2 Pages: 161-172
- DOI
  10.32794/mr112500147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K16821, KAKENHI-PROJECT-22K11823, KAKENHI-PROJECT-23K10933, KAKENHI-PROJECT-23K11802
[Journal Article] Activation of RANKL-producing cells under simulated microgravity with a three-dimensional clinostat in regenerating goldfish scales2022
- Author(s)
  Yamamoto, T., Ikegame, M., Kuroda, K., Kobayashi-Sun, J., Hirayama, J., Kobayashi, I., Kawamura, R., Endo, M., Tabuchi, Y., Furusawa, Y., Yachiguchi, K., Sekiguchi, T., Matsubara, H., Yano, S., Hattori, A. and Suzuki, N.
- Journal Title
  
  Biological Sciences in Space
  
  Volume: 36 Issue: 0 Pages: 9-14
- DOI
  10.2187/bss.36.9
- ISSN
  0914-9201, 1349-967X
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06718, KAKENHI-PROJECT-20K12619
[Journal Article] Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish2022
- Author(s)
  Yukino Wada, Hikaru Tsukatani, Chihiro Kuroda, Yurika Miyazaki, Miku Otoshi, Isao Kobayashi
- Journal Title
  
  Development
  
  Volume: 149 Issue: 7
- DOI
  10.1242/dev.200339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06438, KAKENHI-PROJECT-21H02283
[Journal Article] Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo2022
- Author(s)
  Katsuhiro Konno, Jingjing Kobayashi-Sun, Fumio Arai, Isao Kobayashi, Daisuke Sugiyama
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06438
[Journal Article] Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo.2021
- Author(s)
  Katsuhiro Konno, Jingjing Kobayashi-Sun, Fumio Arai, Isao Kobayashi, Daisuke Sugiyama.
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02283
[Journal Article] Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale2020
- Author(s)
  Kobayashi-Sun Jingjing、Suzuki Nobuo、Hattori Atsuhiko、Yamaguchi Masaaki、Kobayashi Isao
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 4 Pages: 644-650
- DOI
  10.1016/j.bbrc.2020.07.075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11016, KAKENHI-PROJECT-19K06438
[Journal Article] Dual role of Jam3b in early hematopoietic and vascular development.2020
- Author(s)
  Kobayashi I, Kobayashi-Sun J, Hirakawa Y, Ouchi M, Yasuda K, Kamei H, Fukuhara S, Yamaguchi M.
- Journal Title
  
  Development
  
  Volume: 147 Issue: 1 Pages: 181040-181040
- DOI
  10.1242/dev.181040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06014, KAKENHI-PROJECT-19K06438, KAKENHI-PROJECT-19K22517, KAKENHI-PROJECT-19K22420
[Journal Article] Uptake of osteoblast-derived extracellular vesicles promotes the differentiation of osteoclasts in the zebrafish scale.2020
- Author(s)
  Kobayashi J, Yamamori S, Kondo M, Kuroda J, Ikegame M, Suzuki N, Kitamura K, et al.
- Journal Title
  
  Communications Biology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06331
[Journal Article] Non-aqueous, zwitterionic solvent as an alternative for dimethyl sulfoxide in the life sciences2020
- Author(s)
  Kosuke Kuroda, Tetsuo Komori, Kojiro Ishibashi, Takuya Uto, Isao Kobayashi, Riki Kadokawa, Yui Kato, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata
- Journal Title
  
  Communications Chemistry
  
  Volume: 3 Issue: 1 Pages: 163-163
- DOI
  10.1038/s42004-020-00409-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06438, KAKENHI-PROJECT-20H03510
[Journal Article] Uptake of Osteoblast-Derived Extracellular Vesicles Promotes the Differentiation of Osteoclasts in the Zebrafish Scale2020
- Author(s)
  Jingjing Kobayashi-Sun, Shiori Yamamori, Mao Kondo, Junpei Kuroda, Mika Ikegame, Nobuo Suzuki, Kei-Ichiro Kitamura, Atsuhiko Hattori, Masaaki Yamaguchi, Isao Kobayashi.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 190-190
- DOI
  10.1038/s42003-020-0925-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16142, KAKENHI-PROJECT-18K11016, KAKENHI-PROJECT-19K06438, KAKENHI-PROJECT-19H00994, KAKENHI-PROJECT-19K22420
[Journal Article] The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway2019
- Author(s)
  Ozaki Kakeru、Yamada Takanori、Horie Tetsuhiro、Ishizaki Atsushi、Hiraiwa Manami、Iezaki Takashi、Park Gyujin、Fukasawa Kazuya、Kamada Hikari、Tokumura Kazuya、Motono Mei、Kaneda Katsuyuki、Ogawa Kazuma、Ochi Hiroki、Sato Shingo、Kobayashi Yasuhiro、Shi Yun-Bo、Taylor Peter M.、Hinoi Eiichi
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 589 Pages: 589-589
- DOI
  10.1126/scisignal.aaw3921
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22680, KAKENHI-PUBLICLY-18H04971, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-19H03777, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-17J06262, KAKENHI-PROJECT-18J13309, KAKENHI-PROJECT-18J22107, KAKENHI-PROJECT-17KT0051, KAKENHI-ORGANIZER-15H05935
[Journal Article] Rap1b promotes Notch signal-mediated hematopoietic stem cell development by enhancing integrin-mediated cell adhesion.2019
- Author(s)
  Rho S., Kobayashi I., Oguri-Nakamura E., Ando K., Fujiwara M., Kamimura N., Hirata H., Iida A., Iwai Y., Mochizuki N., Fukuhara S.
- Journal Title
  
  Developmental Cell
  
  Volume: 印刷中 Issue: 5 Pages: 1-16
- DOI
  10.1016/j.devcel.2019.03.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05125, KAKENHI-PROJECT-17K19689, KAKENHI-PROJECT-16K18549, KAKENHI-PROJECT-17K15393, KAKENHI-PROJECT-17K00887, KAKENHI-PROJECT-19K22517, KAKENHI-PROJECT-19K23835, KAKENHI-PROJECT-19H01022, KAKENHI-PROJECT-16H04657
[Journal Article] RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales2018
- Author(s)
  Tazaki Yuya、Sugitani Kayo、Ogai Kazuhiro、Kobayashi Isao、Kawasaki Haruki、Aoyama Takafumi、Suzuki Nobuo、Tabuchi Yoshiaki、Hattori Atsuhiko、Kitamura Kei-ichiro
- Journal Title
  
  Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
  
  Volume: 225 Pages: 46-58
- DOI
  10.1016/j.cbpa.2018.06.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01353, KAKENHI-PROJECT-17K01945, KAKENHI-PROJECT-18K06331, KAKENHI-PROJECT-18K11016
[Presentation] 母性由来Abcg2aは背側化を抑制して造血・血管発生を促進する2022
- Author(s)
  藤田涼平, 大内円, 小林静静, 小林功
- Organizer
  第４４回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] Inhibition of canonical Wnt signaling maintains hematopoietic stem cells in zebrafish2022
- Author(s)
  Koki Kimura, Shiori Yamamori, Mao Kondo, Isao Kobayashi
- Organizer
  第２７回小型魚類研究会
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] ゼブラフィッシュにおいて古典的Wntシグナルの阻害は造血幹細胞を維持する2022
- Author(s)
  木村昂暉, 山森汐莉, 近藤真央, 小林功
- Organizer
  第４４回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] Jagged-2bは体節内細胞間シグナル伝達を介して造血幹細胞の発生を制御する2022
- Author(s)
  和田友紀乃, 塚谷光, 黒田千央, 宮崎由里圭, 小林功
- Organizer
  第４４回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] 魚類生殖幹細胞の宿主調整を目的としたX線照射による内在性生殖細胞除去技術の開発2022
- Author(s)
  竹内裕、松井一将、西村周馬、小林功
- Organizer
  第22回マリンバイオテクノロジー学会大会
- Data Source
  KAKENHI-PROJECT-21H02283
[Presentation] Jagged-2b triggers intercellular signaling in the somite to establish the hematopoietic stem cell fate in zebrafish2022
- Author(s)
  Yukino Wada, Isao Kobayashi
- Organizer
  The 50th Annual Scientific Meeting of the ISEH-Society for Hematology and Stem Cells
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] Sinusoidal endothelium is a key component of hematopoietic niches in the zebrafish kidney2020
- Author(s)
  Mao Kondo, Shiri Yamamori, Isao Kobayashi
- Organizer
  第４３回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] Developing hematopoietic stem cells acquire adaptability to the final hematopoietic niche2020
- Author(s)
  Shiori Yamamori, Koki Kimura, Mao Kondo, Makoto Taniguchi, Isao Kobayashi
- Organizer
  第２６回小型魚類研究会
- Data Source
  KAKENHI-PROJECT-19K06438
[Presentation] Jam3b regulates hemato-vascular development through the repression of the Erk signaling pathway2018
- Author(s)
  Isao Kobayashi, Jingjing Kobayashi
- Organizer
  ISEH
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15393

1. Suzuki Nobuo (60242476)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 服部淳彦 (70183910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 平山順 (90510363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Eiichi Hinoi (70360865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Takeuchi Yutaka (70418680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 北村敬一郎 (80283117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 古澤之裕 (80632306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 関口俊男 (40378568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 亀井宏泰 (00610362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 鹿島誠 (10780562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 伊藤昭博 (40391859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山田敏之 (40443345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 濱崎将臣 (50506160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Fukuhara Shigetomo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Iida Atsuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 渡辺数基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 佐藤信吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 黒田純平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 田渕圭章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Isao 小林 功

Research Projects

Research Products

Co-Researchers

造血幹細胞の自己複製におけるCD74の役割と制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of transcription factor Tfcp2l1 in growth spurt phenomena in zebrafish

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on prevention of bone disease using fish induced hyperglycemia: Effect of food containing melatonin.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of niche cells for supporting colonization, proliferation, and differentiation of xenogenic donor germ cells in recipient gonads.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of osteoclasts by hormones produced in osteoblasts: analysis using fish scales as a bone model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the integrin-dependent signaling pathway in hematopoietic stem cell development.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel coupling factors produced by osteoclasts and clarification of their secretory phase

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a research platform for developing radical treatment and early predictive diagnostics for scoliosis through nutritional environmental signals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamic analysis of hematopoietic stem cell development in the dorsal aortaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Melatonin is more effective on bone metabolism when given at early night than during the day in ovariectomized rats2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of RANKL-producing cells under simulated microgravity with a three-dimensional clinostat in regenerating goldfish scales2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo2022

Author(s)

Journal Title

Data Source

[Journal Article] Hematopoietic Cell Isolation by Antibody-Free Flow Cytometry in the Zebrafish Embryo.2021

Kobayashi Isao 小林功