Konishi Hiroaki 小西弘晃

Researcher Number	30777181
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 特任講師
Affiliation (based on the past Project Information) *help	2023 – 2025: 旭川医科大学, 医学部, 特任講師 2023: 旭川医科大学, 医学部, 特任助教 2022: 旭川医科大学, 医学部, 客員助教 2021: 旭川医科大学, 医学部, その他 2017 – 2021: 旭川医科大学, 医学部, 特任助教 2016 – 2017: 旭川医科大学, 医学部, 客員助教
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / General physiology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 55060:Emergency medicine-related
Keywords	Principal Investigator プロバイオティクス / 抗腫瘍分子 / 生理活性物質 / 細胞シグナル / 有益菌 / 小児白血病 / Heptelidic acid / 小児がん / 小児癌 / 抗腫瘍物質 … More / 膵癌 / 難治癌 / 難治性癌 / 癌 / アポトーシス / 抗腫瘍活性物質 / 癌治療 / 腸内細菌 / 大腸癌 … More Except Principal Investigator プロバイオティクス / 腸内細菌 / 炎症性腸疾患 / RNA結合蛋白 / circular RNA / 食道扁平上皮癌 / バレット食道癌 / 食道癌 / バレット食道 / 食道腺癌 / 腸－肺連関 / 腸内細菌叢 / ARDS / 腸ー肺連関 / アレルギー性皮膚炎 / 非アルコール性脂肪性肝疾患 / 腸管保護 / 抗腫瘍 / ビフィズス菌 / 乳酸菌 / 麹菌 / 大腸腫瘍 / ポリリン酸 / Heptelidic acid / フェリクローム / 認識機構 / 消化器癌 Less

微生物由来抗癌活性分子による多臓器癌制御機構の解明と癌治療戦略開拓の基盤的研究Principal Investigator
- Principal Investigator
  
  小西弘晃
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Asahikawa Medical College
炎症性腸疾患におけるCircular RNA-RNA結合蛋白相互作用の解析
- Principal Investigator
  
  安藤勝祥
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Development of antitumor drug for pediatric cancer by utilizing probiotic derived antitumor moleculesPrincipal Investigator
- Principal Investigator
  
  小西弘晃
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Asahikawa Medical College
A basic research of developing novel preventions and treatments of Barrett's esophagus using bacteria-derived bioactive molecules
- Principal Investigator
  
  盛一健太郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
有益微生物由来分子を用いた小児白血病治療薬の開発の基盤研究Principal Investigator
- Principal Investigator
  
  小西弘晃
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Asahikawa Medical College
Identifications of bacteria-derived bioactive molecules that possess beneficial effects for extra-intestinal disorders
- Principal Investigator
  
  藤谷幹浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
細菌由来の分子による腸ー肺連関メカニズムに基づいたARDS治療薬開発の基盤研究
- Principal Investigator
  
  高氏修平
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Hokkaido University
  Asahikawa Medical College
The development of novel pancreatic cancer therapeutics based on probiotic-derived anti-tumor molecules.Principal Investigator
- Principal Investigator
  
  Konishi Hiroaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Asahikawa Medical College
Identifications and functional analyses of beneficial bacteria-derived bioactive molecules
- Principal Investigator
  
  Fujiya Mikihiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Identification of probiotic derived bioactive molecule and clarification of its recognition system and activation mechanisms of cell signalingPrincipal Investigator
- Principal Investigator
  
  Konishi Hiroaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General physiology
- Research Institution
  Asahikawa Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent2024
- Author(s)
  Kojima Keita、Konishi Hiroaki、Momosaki Kyoka、Komatani Yuya、Katsuyama Akira、Nakagawa Koji、Kanamitsu Kayoko、Yakushiji Fumika、Fujiya Mikihiro、Ichikawa Satoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 7628-7628
- DOI
  10.1038/s41598-024-58196-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15363, KAKENHI-PROJECT-21KK0291, KAKENHI-PROJECT-23K24001
[Journal Article] Probiotic-derived ferrichrome induces DDIT3-mediated antitumor effects in esophageal cancer cells2024
- Author(s)
  Kunogi Takehito、Konishi Hiroaki、Sakatani Aki、Moriichi Kentaro、Yamamura Chikage、Yamamoto Koji、Kashima Shin、Ando Katsuyoshi、Ueno Nobuhiro、Tanaka Hiroki、Okumura Toshikatsu、Fujiya Mikihiro
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 6 Pages: e28070-e28070
- DOI
  10.1016/j.heliyon.2024.e28070
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15363, KAKENHI-PROJECT-21KK0291, KAKENHI-PROJECT-22K08047
[Journal Article] Therapeutic efficacy of RAS inhibitor trametinib using a juvenile myelomonocytic leukemia patient-derived xenograft model2024
- Author(s)
  Lee Alex Q.、Konishi Hiroaki、Ijiri Masami、Li Yueju、Panigrahi Arun、Chien Jeremy、Satake Noriko
- Journal Title
  
  Pediatric Hematology and Oncology
  
  Volume: - Issue: 5 Pages: 1-9
- DOI
  10.1080/08880018.2024.2343688
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15363, KAKENHI-PROJECT-21KK0291
[Journal Article] Cmpd10357 to treat B-cell acute lymphoblastic leukemia2023
- Author(s)
  Lee Alex Q.、Konishi Hiroaki、Helmke Elizabeth、Ijiri Masami、Lerot Jan Michael A.、Hicks Emma、Chien Jeremy R.、Gorin Fredric A.、Satake Noriko
- Journal Title
  
  Experimental Hematology
  
  Volume: 119-120 Pages: 8-13.e1
- DOI
  10.1016/j.exphem.2022.12.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15363, KAKENHI-PROJECT-21KK0291, KAKENHI-PROJECT-19K16484
[Journal Article] Testis‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization2022
- Author(s)
  Murakami Yuki、Konishi Hiroaki、Fujiya Mikihiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
- Journal Title
  
  Cancer Medicine
  
  Volume: - Issue: 19 Pages: 3643-3656
- DOI
  10.1002/cam4.4738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419
[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022
- Author(s)
  Kawabata Hidemasa、Ono Yusuke、Tamamura Nobue、Oyama Kyohei、Ueda Jun、Sato Hiroki、Takahashi Kenji、Taniue Kenzui、Okada Tetsuhiro、Fujibayashi Syugo、Hayashi Akihiro、ほか
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 3 Pages: 208-220
- DOI
  10.1007/s00535-021-01846-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16947, KAKENHI-PUBLICLY-20H04896, KAKENHI-PROJECT-19K07261, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-20K17009, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-19H03448, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-20K09070, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-19K06452, KAKENHI-PROJECT-21H02758
[Journal Article] A distinct subpopulation of leukemia initiating cells in acute precursor B lymphoblastic leukemia: quiescent phenotype and unique transcriptomic profile2022
- Author(s)
  Lee Alex Q.、Konishi Hiroaki、Duong Connie、Yoshida Sakiko、Davis Ryan R.、Van Dyke Jonathan E.、Ijiri Masami、McLaughlin Bridget、Kim Kyoungmi、Li Yueju、Beckett Laurel、Nitin Nitin、McPherson John D.、Tepper Clifford G.、Satake Noriko
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 12
- DOI
  10.3389/fonc.2022.972323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15363, KAKENHI-PROJECT-21KK0291, KAKENHI-PROJECT-19K16484
[Journal Article] Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model2022
- Author(s)
  Takauji Shuhei、Tanaka Hiroki、Hayakawa Mineji、Horioka Kie、Isozaki Shotaro、Konishi Hiroaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 587 Pages: 1-8
- DOI
  10.1016/j.bbrc.2021.11.086
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K17328, KAKENHI-PROJECT-19KK0225
[Journal Article] Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control2022
- Author(s)
  Isozaki Shotaro、Konishi Hiroaki、Tanaka Hiroki、Yamamura Chikage、Moriichi Kentaro、Ogawa Naoki、Fujiya Mikihiro
- Journal Title
  
  BMC Microbiology
  
  Volume: 22 Issue: 1 Pages: 110-110
- DOI
  10.1186/s12866-022-02530-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-21K07929, KAKENHI-PROJECT-22K17411
[Journal Article] Hypoxia-induced nuclear translocation of β-catenin in the healing process of frostbite2022
- Author(s)
  Isozaki Shotaro、Tanaka Hiroki、Horioka Kie、Konishi Hiroaki、Kashima Shin、Takauji Shuhei、Fujiya Mikihiro、Druid Henrik
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1868 Issue: 6 Pages: 166385-166385
- DOI
  10.1016/j.bbadis.2022.166385
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K17328, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-22K17411
[Journal Article] Probiotic derived polyphosphate accelerates intestinal epithelia wound healing through inducing platelet-derived mediators.2021
- Author(s)
  Isozaki S, Konishi H, Fujiya M, Tanaka H, Murakami Y, Kashima S, Ando K, Ueno N, Moriichi K, Okumura T.
- Journal Title
  
  Mediators of Inflammation
  
  Volume: 2021:5582943 Pages: 1-14
- DOI
  10.1155/2021/5582943
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07927, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-19K17419
[Journal Article] Treatment of hepatocellular carcinoma with autologous platelets encapsulating sorafenib or lenvatinib: A novel therapy exploiting tumor‐platelet interactions2021
- Author(s)
  Tanaka Hiroki、Horioka Kie、Hasebe Takumu、Sawada Koji、Nakajima Shunsuke、Konishi Hiroaki、Isozaki Shotaro、Goto Masanori、Fujii Yumiko、Kamikokura Yuki、Ogawa Katsuhiro、Nishikawa Yuji
- Journal Title
  
  International Journal of Cancer
  
  Volume: 150 Issue: 10 Pages: 1640-1653
- DOI
  10.1002/ijc.33915
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-21K07167, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K17328, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-22K17411
[Journal Article] The Optimal Dose of Tacrolimus in Combination Therapy with an Anti-TNFα Antibody in a Mouse Colitis Model2021
- Author(s)
  Murakami Yuki、Fujiya Mikihiro、Konishi Hiroaki、Isozaki Shotaro、Sugiyama Yuya、Kobayashi Yu、Sasaki Takahiro、Kunogi Takehito、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 4 Pages: 564-570
- DOI
  10.1248/bpb.b20-00916
- NAID
  130008014301
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19K17419
[Journal Article] Polyphosphate, derived from the probiotic Lactobacillus brevis, modulates the intestinal microbiome and attenuates acute pancreatitis.2021
- Author(s)
  Takauji S, Konishi H, Fujiya M, Ueno N, Tanaka H, Sato H, Isozaki S, Kashima S, Moriichi K, Mizukami Y, Okumura T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: - Issue: 11 Pages: 1-1
- DOI
  10.1007/s10620-020-06747-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07927, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-18K08906, KAKENHI-PROJECT-20H03655
[Journal Article] Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer.2021
- Author(s)
  Iwama T, Fujiya M, Konishi H, Tanaka H, Murakami Y, Kunogi T, Sasaki T, Takahashi K, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Okumura T.
- Journal Title
  
  Cancer Cell Int
  
  Volume: 21 Issue: 1 Pages: 21-21
- DOI
  10.1186/s12935-020-01723-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07927, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-19K17419
[Journal Article] Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway.2021
- Author(s)
  Konishi H, Isozaki S, Kashima S, Moriichi K, Ichikawa S, Yamamoto K, Yamamura C, Ando K, Ueno N, Akutsu H, Ogawa N, Fujiya M.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 11070-11070
- DOI
  10.1038/s41598-021-90707-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07927, KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19H03345, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419
[Journal Article] The Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer2021
- Author(s)
  Konishi Hiroaki、Kashima Shin、Goto Takuma、Ando Katsuyoshi、Sakatani Aki、Tanaka Hiroki、Ueno Nobuhiro、Moriichi Kentaro、Okumura Toshikatsu、Fujiya Mikihiro
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 13 Pages: 3165-3165
- DOI
  10.3390/cancers13133165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419
[Journal Article] Tumor-Progressive Mechanisms Mediating miRNA?Protein Interaction2021
- Author(s)
  Konishi Hiroaki、Sato Hiroki、Takahashi Kenji、Fujiya Mikihiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 22 Pages: 12303-12303
- DOI
  10.3390/ijms222212303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17480
[Journal Article] Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 12020
- Author(s)
  Takahashi Keitaro、Fujiya Mikihiro、Konishi Hiroaki、Murakami Yuki、Iwama Takuya、Sasaki Takahiro、Kunogi Takehito、Sakatani Aki、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Tanabe Hiroki、Okumura Toshikatsu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 12 Pages: 4514-4514
- DOI
  10.3390/ijms21124514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419
[Journal Article] A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells.2020
- Author(s)
  Konishi H, Fujiya M, Kashima S, Sakatani A, Dokoshi T, Ando K, Ueno N, Iwama T, Moriichi K, Tanaka H, Okumura T
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 4 Pages: 245-245
- DOI
  10.1038/s41419-020-2439-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419, KAKENHI-PROJECT-17K15911, KAKENHI-PROJECT-19KK0225
[Journal Article] Low temperature induces von-willebrand factor expression via increased early growth response 1 transcriptional activity in splenic sinusoidal endothelial cells.2020
- Author(s)
  Horioka K, Tanaka H, Isozaki S, Konishi H, Addo L, Takauji S, Druid H.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 526 Issue: 1 Pages: 239-245
- DOI
  10.1016/j.bbrc.2020.03.073
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K19477, KAKENHI-PROJECT-19KK0225
[Journal Article] Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis.2020
- Author(s)
  Fujiya M, Ueno N, Kashima S, Tanaka K, Sakatani A, Ando K, Moriichi K, Konishi H, Kamiyama N, Tasaki Y, Omura T, Matsubara K, Taruishi M, Okumura T.
- Journal Title
  
  Clinical Pharmacology & Therapeutics
  
  Volume: 107 Issue: 2 Pages: 452-461
- DOI
  10.1002/cpt.1628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419, KAKENHI-PROJECT-17K15911
[Journal Article] Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model.2020
- Author(s)
  Horioka K, Tanaka H, Isozaki S, Konishi H, Fujiya M, Okuda K, Asari M, Shiono H, Ogawa K, Shimizu K
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 65 Issue: 1 Pages: 132-140
- DOI
  10.1007/s10620-019-05729-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19KK0225
[Journal Article] Probiotic-derived ferrichrome inhibits the growth of refractory pancreatic cancer cells.2020
- Author(s)
  Kita A, Fujiya M, Konishi H, Tanaka H, Kashima S, Iwama T, Ijiri M, Murakami Y, Takauji S, Goto T, Sakatani A, Ando K, Ueno N, Ogawa N, Okumura T.
- Journal Title
  
  Int J Oncol
  
  Volume: 57 Issue: 3 Pages: 721-732
- DOI
  10.3892/ijo.2020.5096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07927, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-19K17419, KAKENHI-PROJECT-19KK0225, KAKENHI-PROJECT-18K15770
[Journal Article] An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker2018
- Author(s)
  Goto Takuma、Fujiya Mikihiro、Konishi Hiroaki、Sasajima Junpei、Fujibayashi Shugo、Hayashi Akihiro、Utsumi Tatsuya、Sato Hiroki、Iwama Takuya、Ijiri Masami、Sakatani Aki、Tanaka Kazuyuki、Nomura Yoshiki、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Mizukami Yusuke、Kohgo Yutaka、Okumura Toshikatsu
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 1-11
- DOI
  10.1186/s12885-018-4006-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09472, KAKENHI-PROJECT-17K15912, KAKENHI-PROJECT-17K15913, KAKENHI-PROJECT-16H06607, KAKENHI-PROJECT-26460956, KAKENHI-PROJECT-15K19306
[Journal Article] Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron binding site in gastric cancer cells2017
- Author(s)
  Masami Ijiri, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Toshikatsu Okumura
- Journal Title
  
  Tumor Biology
  
  Volume: 印刷中
- NAID
  120006473651
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H06607
[Journal Article] Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells2017
- Author(s)
  Ijiri Masami、Fujiya Mikihiro、Konishi Hiroaki、Tanaka Hiroki、Ueno Nobuhiro、Kashima Shin、Moriichi Kentaro、Sasajima Junpei、Ikuta Katsuya、Okumura Toshikatsu
- Journal Title
  
  Tumor Biology
  
  Volume: 39 Issue: 6 Pages: 101042831771131-101042831771131
- DOI
  10.1177/1010428317711311
- NAID
  120006473651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06607, KAKENHI-PROJECT-26460956, KAKENHI-PROJECT-15K19306
[Journal Article] Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis2016
- Author(s)
  Hiroaki Konishi, Mikihiro Fujiya, Hiroki Tanaka, Nobuhiro Ueno, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Hiroaki Akutsu, Hiroki Tanabe, Yutaka Kohgo
- Journal Title
  
  Nature Communications
  
  Volume: 7:12365 Issue: 1 Pages: 12365-12365
- DOI
  10.1038/ncomms12365
- NAID
  120006305684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06607, KAKENHI-PROJECT-15K09446, KAKENHI-PROJECT-26460956
[Patent] 血小板凝集剤2020
- Inventor(s)
  藤谷幹浩、小西弘晃、田中宏樹、磯崎翔太郎、大町佳宏、尾川直樹
- Industrial Property Rights Holder
  藤谷幹浩、小西弘晃、田中宏樹、磯崎翔太郎、大町佳宏、尾川直樹
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K16484
[Patent] 血小板凝集剤2020
- Inventor(s)
  藤谷幹浩、小西弘晃、田中宏樹、磯崎翔太郎、大野佳宏、尾川直樹
- Industrial Property Rights Holder
  藤谷幹浩、小西弘晃、田中宏樹、磯崎翔太郎、大野佳宏、尾川直樹
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K07927
[Patent] 抗腫瘍剤2017
- Inventor(s)
  藤谷幹浩、小西弘晃、盛一健太郎
- Industrial Property Rights Holder
  国立大学法人旭川医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017-01-19
- Overseas
- Data Source
  KAKENHI-PROJECT-16H06607
[Patent] 抗腫瘍剤2017
- Inventor(s)
  藤谷幹浩、小西弘晃、盛一健太郎
- Industrial Property Rights Holder
  国立大学法人旭川医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017-01-19
- Data Source
  KAKENHI-PROJECT-16H06607
[Presentation] Targeting the spliceosome in high-risk B-cell acute lymphoblastic leukemia2024
- Author(s)
  Murakami Y, Konishi H, Tepper C, McPherson J, Satake N
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15363
[Presentation] Targeting the spliceosome in high-risk B-cell acute lymphoblastic leukemia2024
- Author(s)
  Murakami Y, Konishi H, Tepper C, McPherson J, Satake N
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0291
[Presentation] RAB3GAP1-mediated mitosis and growth due to a tumor-specific status of RNA binding protein2023
- Author(s)
  Konishi H, Murakami Y, Ando K, Sakatani A, Sasaki T, Takahashi K, Ueno N, Kashima S, Tanaka H, Moriichi K, Fujiya M
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15363
[Presentation] Probiotic derived heptelidic acid is cytotoxic in pediatric B-cell acute lymphoblastic leukemia2023
- Author(s)
  Konishi H, Murakami Y, Yamamoto K, Yamamura C, Satake N, Fujiya M
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K15363
[Presentation] Probiotic-derived heptelidic acid demonstrates therapeutic efficacy against pediatric B-cell acute lymphoblastic leukemia2023
- Author(s)
  Konishi H, Murakami Y, Helmke E, Lerot JMA, Satake N
- Organizer
  American Hematopoietic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21KK0291
[Presentation] Probiotic derived heptelidic acid is cytotoxic in pediatric B-cell acute lymphoblastic leukemia2023
- Author(s)
  Konishi H, Murakami Y, Yamamoto K, Yamamura C, Satake N, Fujiya M
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21KK0291
[Presentation] RAB3GAP1-mediated mitosis and growth due to a tumor-specific status of RNA binding protein2023
- Author(s)
  Konishi H, Murakami Y, Ando K, Sakatani A, Sasaki T, Takahashi K, Ueno N, Kashima S, Tanaka H, Moriichi K, Fujiya M
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21KK0291
[Presentation] Probiotic-derived heptelidic acid demonstrates therapeutic efficacy against pediatric B-cell acute lymphoblastic leukemia2023
- Author(s)
  Konishi H, Murakami Y, Helmke E, Lerot JMA, Satake N
- Organizer
  American Hematopoietic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15363
[Presentation] Probiotic derived heptelidic acid exerts anti-tumor effects to distant melanoma through the inhibition of Glyceraldehyde-3-Phosphate Dehydrogenase activity2022
- Author(s)
  Shotaro Isozaki, Hiroaki Konishi, Hiroki Tanaka, Chikage Yamamura, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takahiro Sasaki, Takehito Kunogi, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Mikihiro Fujiya
- Organizer
  Digestive Disease Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Probiotic polyphosphate improves the intestinal injury through the integrin mediated endocytic pathway2022
- Author(s)
  Hiroaki Konishi, Shotaro Isozaki, Chikage Yamamura, Shin Kashima, Kentaro Moriichi, Mikihiro Fujiya
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] 麹菌由来Heptelidic acidはp38MAPKシグナルカスケードを介して膵癌細胞にアポトーシスを誘導する2022
- Author(s)
  小西　弘晃、山村　千景、磯崎　翔太郎、盛一　健太郎、市川　聡、藤谷　幹浩
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] 乳酸菌由来長鎖ポリリン酸は腸内細菌叢を変化させ急性膵炎を改善する2021
- Author(s)
  小西　弘晃、高氏　修平、嘉島　伸、高橋　慶太郎、久野木　健仁、佐々木　貴弘、村上　雄紀、杉山　雄哉、小林　裕、安藤　勝祥、上野　伸展、盛一　健太郎、藤谷幹浩
- Organizer
  第58回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Probiotic ferrichrome exhibited the anti-tumor effect mediating the endoplasmic stress pathway in colorectal cancer cells2021
- Author(s)
  Hiroaki Konishi, Takuya Iwama, Hiroki Tanaka, Shotaro Isozaki, Chikage Yamamura, Satoshi Ichikawa, Kentaro Moriichi, Mikihiro Fujiya
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] 乳酸菌由来長鎖ポリリン酸は上皮インテグリンβ1シグナルを介して腸炎治療効果を発揮する2021
- Author(s)
  小西弘晃、嘉島伸、磯崎翔太朗、山村千景、奥村利勝、藤谷幹浩
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Ferrichrome derived from probiotic Lactobacillus exhibits anti-tumor effect mediating upregulation of endoplasmic reticulum stress signaling in colorectal cancer2020
- Author(s)
  小西弘晃、藤谷幹浩、喜多朱美、磯崎翔太朗、奥村利勝
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] 乳酸菌由来長鎖ポリリン酸は血小板活性化を介して腸管上皮の創傷治癒を促進する2020
- Author(s)
  磯崎翔太郎、藤谷幹浩、小西弘晃、田中宏樹、村上雄紀、杉山雄哉、安藤勝祥、上野伸展、後藤拓磨、嘉島伸、高氏修平、盛一健太郎、田邊裕貴、水上裕輔、奥村利勝
- Organizer
  第57回消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07927
[Presentation] PROBIOTIC-DERIVED POLYPHOSPHATE IMPROVES DAMAGED INTESTINAL EPITHELIA THROUGH INDUCING PLATELET-DERIVED CELL GROWTH MOLECULES2020
- Author(s)
  磯崎　翔太郎、藤谷　幹浩、小西　弘晃、田中　宏樹、村上　雄紀、杉山　雄哉、小林　裕、佐々木　貴弘、久野木　健仁、高橋　慶太郎、田中　一之、坂谷　慧、安藤　勝祥、上野　伸展、嘉島　伸、後藤　拓磨、高氏　修平、盛一　健太郎、田邊　裕貴、水上　祐輔、奥村　利勝
- Organizer
  Digestive Disease Week 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Ferrichrome, derived from probiotic bacteria, exerts an antitumor effect against colorectal cancer cells2020
- Author(s)
  Hiroaki Konishi, Mikihiro Fujiya, Hiroki Tanaka, Toshikatsu Okumura
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Probiotic-derived ferrichrome inhibits the growth of refractory pancreatic cancer cells.2020
- Author(s)
  喜多　朱美、藤谷　幹浩、小西　弘晃、田中　宏樹、嘉島　伸、磯崎　翔太郎、杉山　雄哉、久野木　健仁、高橋　慶太郎、岩間　琢也、井尻　学見、村上　雄紀、高氏　修平、後藤　拓磨、坂谷　慧、安藤　勝祥、上野　伸展、盛一　健太郎、田邊　裕貴、水上　祐輔、奥村　利勝
- Organizer
  Digestive Disease Week 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Ferrichrome derived from probiotic Lactobacillus casei is antitumor molecule for gastrointestinal cancer cells.2019
- Author(s)
  Hiroaki Konishi, Akemi Kita, Mikihiro Fujiya
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16484
[Presentation] Ferrichrome, a tumor suppressive molecule derived from Lactobacillus casei, inhibits the progression of colorectal cancer via the endoplasmic reticulum stress pathway2017
- Author(s)
  Hiroaki Konishi, Mikihiro Fujiya, Masami Ijiri, Kazuyuki Tanaka, Shugo Fujibayashi, Takuma Goto, Shin Kashima, Katsuyoshi Ando, Keitaro Takahashi, Nobuhiro Ueno, Junpei Sasajima, Kentaro Moriichi, Hiroki Tanaka, Katsuya Ikuta, Katsutoshi Okumura
- Organizer
  Digestive Disease Week 2017
- Place of Presentation
  McCormick Place、米国、シカゴ
- Year and Date
  2017-05-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06607
[Presentation] Ferrichrome, a tumor suppressive molecule derived from Lactobacillus casei, inhibits the progression of colorectal cancer via the endoplasmic reticulum stress pathway2017
- Author(s)
  Konishi H, Fujiya M, Ijiri M,　Tanaka K, Fujibayashi S, Goto T, Kashima S, Ando K, Takahashi K, Ueno N, Sasajima J, Moriichi K, Tanaka H, Ikuta K, Okumura T
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06607

1. Fujiya Mikihiro (80322915)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. 上野伸展 (30436000)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 盛一健太郎 (70455715)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 嘉島伸 (10548655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 澤田康司 (80548660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高氏修平 (20793897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 安藤勝祥 (70548677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋賢治 (00736332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 林明宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 磯崎翔太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 水上裕輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 笹島順平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Konishi Hiroaki 小西 弘晃

Research Projects

Research Products

Co-Researchers

微生物由来抗癌活性分子による多臓器癌制御機構の解明と癌治療戦略開拓の基盤的研究Principal Investigator

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炎症性腸疾患におけるCircular RNA-RNA結合蛋白相互作用の解析

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Development of antitumor drug for pediatric cancer by utilizing probiotic derived antitumor moleculesPrincipal Investigator

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A basic research of developing novel preventions and treatments of Barrett's esophagus using bacteria-derived bioactive molecules

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有益微生物由来分子を用いた小児白血病治療薬の開発の基盤研究Principal Investigator

Principal Investigator

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Identifications of bacteria-derived bioactive molecules that possess beneficial effects for extra-intestinal disorders

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細菌由来の分子による腸ー肺連関メカニズムに基づいたARDS治療薬開発の基盤研究

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Research Institution

The development of novel pancreatic cancer therapeutics based on probiotic-derived anti-tumor molecules.Principal Investigator

Principal Investigator

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Review Section

Research Institution

Identifications and functional analyses of beneficial bacteria-derived bioactive molecules

Principal Investigator

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Review Section

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Identification of probiotic derived bioactive molecule and clarification of its recognition system and activation mechanisms of cell signalingPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent2024

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Data Source

[Journal Article] Probiotic-derived ferrichrome induces DDIT3-mediated antitumor effects in esophageal cancer cells2024

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[Journal Article] Therapeutic efficacy of RAS inhibitor trametinib using a juvenile myelomonocytic leukemia patient-derived xenograft model2024

Author(s)

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[Journal Article] Cmpd10357 to treat B-cell acute lymphoblastic leukemia2023

Konishi Hiroaki 小西弘晃