Hasebe Fumihito 長谷部文人

Researcher Number	30781801
Other IDs	https://orcid.org/0000-0002-1097-3813
Affiliation (Current)	2026: 福井県立大学, 生物資源学部, 准教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 福井県立大学, 生物資源学部, 准教授 2021 – 2025: 福井県立大学, 生物資源学部, 助教 2017 – 2020: 静岡県立大学, 食品栄養科学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 38020:Applied microbiology-related / Applied microbiology Except Principal Investigator Transformative Research Areas, Section (II) / Applied microbiology
Keywords	Principal Investigator 生合成 / メチオニン / 硫黄キャリアタンパク質 / 放線菌 / タンパク質間相互作用 / メチオニン生合成 / アミノ酸 / 活性制御 / フィードバック阻害 / 応用微生物学 … More / 生物有機化学 / トロピノン / 微生物生産 / アルカロイド … More Except Principal Investigator 二次代謝 / 生合成 / ペプチド系天然物 / 二次代謝生合成 / 非タンパク性アミノ酸 / 中分子ペプチド / 微生物 / 蛋白質 / 二次代謝産物 / malonyl-CoA / 大腸菌 Less

Elucidation of the molecular basis of sulfur carrier protein recognizing mechanism in methionine biosynthesisPrincipal Investigator
- Principal Investigator
  
  長谷部文人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Fukui Prefectural University
Elucidation of a novel methionine biosynthetic pathway in BacteriaPrincipal Investigator
- Principal Investigator
  
  Hasebe Fumihito
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Fukui Prefectural University
Development of novel peptide compounds derived from microorganisms using new technology.
- Principal Investigator
  
  丸山千登勢
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Fukui Prefectural University
Studies on novel feedback mechanism of methionine biosynthetic enzymePrincipal Investigator
- Principal Investigator
  
  Hasebe Fumihito
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Fukui Prefectural University
  University of Shizuoka
Mechanistic analysis of high-yield protein production in E. coli for the production of natural products
- Principal Investigator
  
  FUna Nobutaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  University of Shizuoka
Study for screening enzymes involved in biosynthesis of ornithine-derived alkaloids, and microbial productionPrincipal Investigator
- Principal Investigator
  
  Hasebe Fumihito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  University of Shizuoka

All 2024 2023 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Cell-penetrating activity of a short-chain ε-poly-l-α-lysine2024
- Author(s)
  Kaneda Kohei、Takeuchi Yamato、Yamanaka Kazuya、Hasebe Fumihito、Maruyama Chitose、Hamano Yoshimitsu
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 138 Issue: 3 Pages: 249-253
- DOI
  10.1016/j.jbiosc.2024.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05122, KAKENHI-PROJECT-22K05412
[Journal Article] Discovery of a novel methionine biosynthetic route O-phospho-L-homoserine2024
- Author(s)
  Hasebe Fumihito、Adachi Kazuya、Maruyama Chitose、Hamano Yoshimitsu
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 90 Issue: 10 Pages: 1-19
- DOI
  10.1128/aem.01247-24
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05122, KAKENHI-PROJECT-22K05412
[Journal Article] Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-l-lysine production in Streptomyces albulus2023
- Author(s)
  Hasebe Fumihito、Adachi Kazuya、Yamanaka Kazuya、Oikawa Tadao、Maruyama Chitose、Hamano Yoshimitsu
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 76 Issue: 9 Pages: 522-531
- DOI
  10.1038/s41429-023-00636-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05412, KAKENHI-PLANNED-22H05122
[Journal Article] MetW regulates the enzymatic activity of MetX in Pseudomonas2021
- Author(s)
  Hasebe Fumihito
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 2 Pages: 351-358
- DOI
  10.1093/bbb/zbaa044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15437
[Journal Article] Identification and characterization of bacterial enzymes catalyzing the synthesis of 1,8-dihydroxynaphthalene, a key precursor of dihydroxynaphthalene melanin, from Sorangium cellulosum2018
- Author(s)
  Yusuke Sone, Shuto Nakamura, Makoto Sasaki, Fumihito Hasebe, Seung-Young Kim, and Nobutaka Funa
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 84 Issue: 9
- DOI
  10.1128/aem.00258-18
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05447, KAKENHI-PROJECT-17K07726
[Presentation] Discovery of a novel methionine biosynthetic route via O-phospho-l-homoserine2024
- Author(s)
  Hasebe F.
- Organizer
  The 2nd Taiwan-Japan International Symposium on Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 抗生物質resormucinが有するβ-homolysineの生合成機構の解明2024
- Author(s)
  今堀千咲, 小笠原泰志, 山中一也, 長谷部文人, 五十嵐雅之, 大利徹, 濱野吉十, 丸山千登勢
- Organizer
  2024年度日本農芸化学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 硫黄キャリアタンパク質を介した新規メチオニン生合成経路の解明2024
- Author(s)
  長谷部文人, 足立和也, 丸山千登勢, 濱野吉十
- Organizer
  予知生合成科学, 2024年若手合宿勉強会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] Exploring the bioactive potential of peptide natural products by enhancing cell-membrane permeability2024
- Author(s)
  K. Kaneda, K. Suzuki, T. Ogura, F. Hasebe, C. Maruyama, Y. Hamano
- Organizer
  第61回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 潜在機能覚醒技術を用いた微生物由来新規ペプチド化合物の開拓－新規なメチオニン生合成経路の解明－2024
- Author(s)
  長谷部文人
- Organizer
  学術変革領域研究(A)「予知生合成科学」第4回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] IECE法による微生物細胞内へのタンパク質／酵素の直接導入法の開発2024
- Author(s)
  大塚早葉, 兼田康平, 長谷部文人, 丸山千登勢, 荒川賢治, 濱野吉十
- Organizer
  2024年度日本農芸化学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 胞膜透過性改善技術による天然ペプチド化合物の潜在的生理活性の探索2024
- Author(s)
  兼田康平, 小倉知也, 鈴木海渡, 長谷部文人, 丸山千登勢, 濱野吉十
- Organizer
  2024年度日本農芸化学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 放線菌Streptomyces albulusにおけるε-poly-L-lysine生産時のL-lysine生合成に関する研究2024
- Author(s)
  嶋田大佑, 丸山千登勢, 濱野吉十, 長谷部文人
- Organizer
  第38回（2024年度）日本放線菌学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] Streptothricin類縁化合物SF2111Bが有するO-acylpeptide構造の生合成機構解明2024
- Author(s)
  松田貫暉, 内山駿, 小笠原泰志, 橋本絢子, 長谷部文人, 新家一男, 大利徹, 濱野吉十, 丸山千登勢
- Organizer
  予知生合成科学, 2024年若手合宿勉強会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 放線菌Streptomyces albulusにおける硫黄キャリアタンパク質を介した新規メチオニン生合成経路の解明2024
- Author(s)
  足立和也, 丸山千登勢, 濱野吉十, 長谷部文人
- Organizer
  2024年度日本農芸化学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] PIECE法によるペプチド化合物の細胞膜透過性改善2024
- Author(s)
  兼田康平, 鈴木海渡, 小倉知也, 長谷部文人, 丸山千登勢, 濱野吉十
- Organizer
  第38回（2024年度）日本放線菌学会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] Discovery of a novel methionine biosynthetic route in Streptomyces2024
- Author(s)
  Hasebe F.
- Organizer
  1st core to core International Biosynposium 2024
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] PIECE法によるペプチド化合物の細胞膜透過性改善2024
- Author(s)
  兼田康平, 鈴木海渡, 小倉知也, 長谷部文人, 丸山千登勢, 濱野吉十
- Organizer
  予知生合成科学, 2024年若手合宿勉強会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 放線菌Streptomyces albulusにおける新規methionine生合成経路の解明2023
- Author(s)
  足立和也, 丸山千登勢, 濱野吉十, 長谷部文人
- Organizer
  2023年度日本放線菌学会大会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] EPSILON-POLY-L-ALPHA-LYSINE, A BACTERIAL POLYCATIONIC ISOPEPTIDE, DIRECTLY PENETRATES THE MAMMALIAN CELL MEMBRANE AND SUPPORTS THE INTERNALIZATIONS OF CANONICAL CELL-PENETRATING PEPTIDES2023
- Author(s)
  Y. Takeuchi, F. Hasebe, C. Maruyama, Y. Hamano
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] Improvement of the cellular internalization of the canonical CPP-protein conjugates by ε-poly-L-lysine2023
- Author(s)
  Y. Takeuchi, F. Hasebe, C. Maruyama, Y. Hamano
- Organizer
  第60回ペプチド討論会
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] CONSTITUTIVE EXPRESSION OF A GENE FOR LYSINE BIOSYNTHESIS ACCELERATED THE PRODUCTION OF Ε-POLY-L-LYSINE IN STREPTOMYCES ALBULUS2023
- Author(s)
  F. Hasebe, K. Adachi, K. Yamanaka, T. Oikawa, C. Maruyama, Y. Hamano
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] 抗生物質resormycinが有するβ-homolysineの生合成機構の解明2023
- Author(s)
  今堀千咲, 山中一也, 小笠原泰志, 五十嵐雅之, 大利徹, 長谷部文人, 濱野吉十, 丸山千登勢
- Organizer
  2023年度日本放線菌学会大会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] ε-poly-L-α-lysine-doxorubicin コンジュゲートを用いたDNA 導入技術の開発2023
- Author(s)
  山中雅喜，武内大和，長谷部文人，丸山千登勢，濱野吉十
- Organizer
  2023年度日本農芸化学会中部・関西支部合同大会
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] Cytotoxicities of membrane-impermeable polar peptides modified with a polycationic isopeptide entering cells (PIECE)2023
- Author(s)
  K. Kaneda, K. Suzuki, T. Ogura, F. Hasebe, C. Maruyama, Y. Hamano
- Organizer
  第60回ペプチド討論会
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05122
[Presentation] メチオニン生合成におけるMetWによるMetXの活性制御2021
- Author(s)
  長谷部文人
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20K15437
[Presentation] 大腸菌と酵母の共培養によるTropinone の生産2020
- Author(s)
  室田健来，長谷部文人，大石和敬，鮒　信学
- Organizer
  日本農芸化学会2020年度（令和2年度）大会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] トロパンアルカロイド生合成を担うIII型ポリケチド合成酵素 CHSBの機能解析2019
- Author(s)
  庄司翼、長谷部文人、弓場穂香、鮒信学
- Organizer
  第37 回日本植物細胞分子生物学会（京都）大会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] 大腸菌を用いたオルニチン由来アルカロイド生合成中間体の生産2018
- Author(s)
  室田健来、大石和敬、川嶋智佳、谷美生夏、相沢光輝、長谷部文人、鮒信学
- Organizer
  酵素工学研究会第80回講演会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] Microbial production 1-methyl-Δ1-pyrrolinium cation, a key intermediate of ornithine-derived alkaloids2018
- Author(s)
  Katsuki Muroda, Kazuhiro Ohishi, Tomoka Kawashima, Mioka Tani,Teruki Aizawa, Fumihito Hasebe, and Nobutaka Funa
- Organizer
  The 4th International Conference on Pharma-Food (ICPF 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] Nicotine の骨格形成反応を担う酵素の探索2018
- Author(s)
  川嶋智佳、長谷部文人、鮒信学
- Organizer
  日本農芸化学会中部支部第 183 回例会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] 組換え大腸菌を用いた flavonoid alkaloidの生産2018
- Author(s)
  大石和敬, 川嶋智佳, 谷美生夏, 相沢光輝, 長谷部文人, 鮒信学
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] 大腸菌を用いたオルニチン由来アルカロイド生合成中間体の生産2018
- Author(s)
  室田健来、大石和敬、川嶋智佳、谷美生夏、相沢光輝、長谷部文人、鮒信学
- Organizer
  日本農芸化学会中部支部第 183 回例会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] The microbial production of 1-methyl-Δ1-pyrrolinium cation, a common intermediate of nicotine and tropane alkaloids, in Escherichia coli2018
- Author(s)
  Fumihito Hasebe, Katsuki Muroda, Tomoka Kawashima, Kazuhiro Oishi, Mioka Tani, Teruki Aizawa, and Nobutaka Funa
- Organizer
  15th Japan-China-Korea Joint Symposium on Enzyme Engineering
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] オルニチン由来アルカロイドにおける共通生合成中間体の微生物生産2018
- Author(s)
  Fumihito Hasebe, Katsuki Muroda, Tomoka Kawashima, Kazuhiro Oishi, Mioka Tani, Teruki Aizawa, and Nobutaka Funa
- Organizer
  新学術領域研究「生合成リデザイン」第2回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] In vitro analysis of A622, a plausible NADPH-dependent reductase,2018
- Author(s)
  Tomoka Kawashima, Fumihito Hasebe, and Nobutaka Funa
- Organizer
  The 4th International Conference on Pharma-Food (ICPF 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] ニコチン生合成関連酵素A622の基質探索2018
- Author(s)
  川嶋智佳、長谷部文人、鮒信学
- Organizer
  酵素工学研究会第80回講演会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] ニコチンの骨格形成反応を担う酵素の探索2017
- Author(s)
  川嶋智佳, 長谷部文人, 鮒信学
- Organizer
  生合成リデザイン_第1回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] オルニチン由来アルカロイドにおける生合成中間体の微生物生産2017
- Author(s)
  長谷部文人、室田健来、大石和敬、川嶋智佳、谷美生夏、相沢光輝、鮒信学
- Organizer
  酵素工学研究会第78回講演会
- Data Source
  KAKENHI-PROJECT-17K18002
[Presentation] オルニチン由来アルカロイドの微生物生産系の構築にむけて2017
- Author(s)
  長谷部文人, 大石和敬, 室田健来, 川嶋智佳, 鮒信学
- Organizer
  生合成リデザイン_第1回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-17K18002

1. FUna Nobutaka (70361574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 丸山千登勢 (20452120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results

Hasebe Fumihito 長谷部 文人

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular basis of sulfur carrier protein recognizing mechanism in methionine biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel methionine biosynthetic pathway in BacteriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel peptide compounds derived from microorganisms using new technology.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on novel feedback mechanism of methionine biosynthetic enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanistic analysis of high-yield protein production in E. coli for the production of natural products

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for screening enzymes involved in biosynthesis of ornithine-derived alkaloids, and microbial productionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cell-penetrating activity of a short-chain ε-poly-l-α-lysine2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of a novel methionine biosynthetic route O-phospho-L-homoserine2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-l-lysine production in Streptomyces albulus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MetW regulates the enzymatic activity of MetX in Pseudomonas2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of bacterial enzymes catalyzing the synthesis of 1,8-dihydroxynaphthalene, a key precursor of dihydroxynaphthalene melanin, from Sorangium cellulosum2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Discovery of a novel methionine biosynthetic route via O-phospho-l-homoserine2024

Author(s)

Organizer

Data Source

[Presentation] 抗生物質resormucinが有するβ-homolysineの生合成機構の解明2024

Author(s)

Organizer

Data Source

[Presentation] 硫黄キャリアタンパク質を介した新規メチオニン生合成経路の解明2024

Author(s)

Organizer

Data Source

[Presentation] Exploring the bioactive potential of peptide natural products by enhancing cell-membrane permeability2024

Author(s)

Organizer

Hasebe Fumihito 長谷部文人