Shimba Akihiro 榛葉旭恒

Researcher Number	30812242
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 特定助教 2019 – 2024: 京都大学, 医学研究科, 助教 2018: 京都大学, ウイルス・再生医科学研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related Except Principal Investigator Basic Section 49070:Immunology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator ヘルパーT細胞 / 炎症性腸疾患 / 大腸炎 / ストレス / 概日リズム / がん免疫 / 関節リウマチ / マトリックスメタロプロテアーゼ / 関節炎 / 好中球 … More / MMP25 / TH17 / TH17細胞 / 精神的ストレス / レニン / ＴＨ17 / ステロイドホルモン / ILC3 / Th17細胞 / グルココルチコイド … More Except Principal Investigator 腫瘍免疫 / IL-15 / 微小環境 / サイトカイン / 自然免疫 / メラノプシン網膜神経節細胞 / 照明機器 / 看護ケア / 概日リズム / 条件等色 / 抗ウイルス免疫応答 / 関節リウマチ / 実験的自己免疫性脳脊髄炎 / Th17細胞 / 自己免疫疾患 / グルココルチコイド Less

リソソーム機能の概日リズムがCD8T細胞の抗がん免疫応答を制御する機構の解明Principal Investigator
- Principal Investigator
  
  榛葉旭恒
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes
- Principal Investigator
  
  生田宏一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Development of nighttime lighting to promote patient sleep under metameric conditions
- Principal Investigator
  
  若村智子
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kyoto University
ストレスがTH17細胞のプロテアーゼの発現上昇と関節炎増悪に寄与する機構の解明Principal Investigator
- Principal Investigator
  
  榛葉旭恒
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Induction of autoimmune diseases by glucocorticoids
- Principal Investigator
  
  IKUTA Koichi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Stress-induced renin causes intestinal inflammation via helper T cellsPrincipal Investigator
- Principal Investigator
  
  Shimba Akihiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases
- Principal Investigator
  
  Ikuta Koichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Glucocorticoids enhance the differentiation and function of Th17 cells and cause colitisPrincipal Investigator
- Principal Investigator
  
  Shimba Akihiro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches2023
- Author(s)
  Asahi Takuma、Abe Shinya、Cui Guangwei、Shimba Akihiro、Nabekura Tsukasa、Miyachi Hitoshi、Kitano Satsuki、Ohira Keizo、Dijkstra Johannes M、Miyazaki Masaki、Shibuya Akira、Ohno Hiroshi、Ikuta Koichi
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-22
- DOI
  10.7554/elife.84209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K19430, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
[Journal Article] Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow2023
- Author(s)
  Abe Shinya、Asahi Takuma、Hara Takahiro、Cui Guangwei、Shimba Akihiro、Tani-ichi Shizue、Yamada Kohei、Miyazaki Kazuko、Miyachi Hitoshi、Kitano Satsuki、Nakamura Naotoshi、Kikuta Junichi、Vandenbon Alexis、Miyazaki Masaki、Yamada Ryo、Ohteki Toshiaki、Ishii Masaru、Sexl Veronika、Nagasawa Takashi、Ikuta Koichi
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 9 Pages: 113127-113127
- DOI
  10.1016/j.celrep.2023.113127
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-21K08370, KAKENHI-PROJECT-22K19430, KAKENHI-PUBLICLY-22H05627, KAKENHI-PROJECT-23K24152, KAKENHI-PROJECT-23K27425, KAKENHI-PROJECT-23K27426
[Journal Article] Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation2023
- Author(s)
  Takami Daichi、Abe Shinya、Shimba Akihiro、Asahi Takuma、Cui Guangwei、Tani-ichi Shizue、Hara Takahiro、Miyata Keishi、Ikutani Masashi、Takatsu Kiyoshi、Oike Yuichi、Ikuta Koichi
- Journal Title
  
  International Immunology
  
  Volume: 35 Issue: 11 Pages: 513-530
- DOI
  10.1093/intimm/dxad029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-23K27426
[Journal Article] CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s2023
- Author(s)
  Cui Guangwei、Shimba Akihiro、Jin Jianshi、Hojo Nozomi、Asahi Takuma、Abe Shinya、Ejima Aki、Okada Shinri、Ohira Keizo、Kato Ryoma、Tani-ichi Shizue、Yamada Ryo、Ebihara Takashi、Shiroguchi Katsuyuki、Ikuta Koichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 36
- DOI
  10.1073/pnas.2215941120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-21K19368, KAKENHI-PROJECT-23K27426
[Journal Article] A circulating subset of iNKT cells mediates antitumor and antiviral immunity2022
- Author(s)
  Cui G, Shimba A, et.al
- Journal Title
  
  Science Immunology
  
  Volume: 7 Issue: 76 Pages: 8760-8760
- DOI
  10.1126/sciimmunol.abj8760
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07545, KAKENHI-PROJECT-22K07086, KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-20K21522, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-20K17580, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-21J15058
[Journal Article] Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks2022
- Author(s)
  Akter Salma、Shimba Akihiro、Ikuta Koichi、Mahmud Md. Rasel Al、Yamada Shintaro、Sasanuma Hiroyuki、Tsuda Masataka、Sone Masakatsu、Ago Yukio、Murai Kenichi、Tanaka Hisashi、Takeda Shunichi
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 1 Pages: 53-67
- DOI
  10.1111/gtc.12993
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07148, KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-20K09539
[Journal Article] Control of immunity and allergy by steroid hormones2022
- Author(s)
  Ikuta Koichi、Ejima Aki、Abe Shinya、Shimba Akihiro
- Journal Title
  
  Allergol. Int.
  
  Volume: 71 Issue: 4 Pages: 432-436
- DOI
  10.1016/j.alit.2022.07.006
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07133
[Journal Article] Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells2022
- Author(s)
  Ejima Aki、Abe Shinya、Shimba Akihiro、Sato Susumu、Uehata Takuya、Tani-ichi Shizue、Munakata Satoru、Cui Guangwei、Takeuchi Osamu、Hirai Toyohiro、Kato Shigeaki、Ikuta Koichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 6 Pages: 1083-1094
- DOI
  10.4049/jimmunol.2200294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07133, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-20H03501
[Journal Article] Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress2021
- Author(s)
  Akihiro Shimba, Aki Ejima, Koichi Ikuta
- Journal Title
  
  Front Immunol
  
  Volume: 706951
- DOI
  10.3389/fimmu.2021.706951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16280
[Journal Article] Control of immunity by glucocorticoids in health and disease.2020
- Author(s)
  Shimba A. and Ikuta K.
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: 42 Issue: 6 Pages: 669-680
- DOI
  10.1007/s00281-020-00827-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
[Journal Article] Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice2020
- Author(s)
  Inokawa Hitoshi, Umemura Yasuhiro, Shimba Akihiro, Kawakami Eiryo, Koike Nobuya, Tsuchiya Yoshiki, Ohashi Munehiro, Minami Yoichi, Cui Guangwei, Asahi Takuma, Ono Ryutaro, Sasawaki Yuh, Konishi Eiichi, Yoo Seung-Hee, Chen Zheng, Teramukai Satoshi, Ikuta Koichi, Yagita Kazuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 2569-2569
- DOI
  10.1038/s41598-020-59541-y
- NAID
  120006799241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22516, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-17K11021, KAKENHI-PROJECT-17KT0129, KAKENHI-PROJECT-18K15184
[Journal Article] Immune-enhancing effects of glucocorticoids in response to day-night cycles and stress.2020
- Author(s)
  Shimba A. and Ikuta K.
- Journal Title
  
  Int. Immunol.
  
  Volume: 32 Issue: 11 Pages: 703-708
- DOI
  10.1093/intimm/dxaa048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
[Journal Article] Glucocorticoids regulate circadian rhythm of innate and adaptive immunity.2020
- Author(s)
  Shimba A. and Ikuta K.
- Journal Title
  
  Front. Immunol.
  
  Volume: 11 Pages: 2143-2143
- DOI
  10.3389/fimmu.2020.02143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21525, KAKENHI-PROJECT-20K16280
[Journal Article] Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine2019
- Author(s)
  Zhu Yuanbo、Cui Guangwei、Miyauchi Eiji、Nakanishi Yuki、Mukohira Hisa、Shimba Akihiro、Abe Shinya、Tani-ichi Shizue、Hara Takahiro、Nakase Hiroshi、Chiba Tsutomu、Sehara-Fujisawa Atsuko、Seno Hiroshi、Ohno Hiroshi、Ikuta Koichi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 5 Pages: 307-319
- DOI
  10.1093/intimm/dxz082
- NAID
  120006846480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05907, KAKENHI-PROJECT-19K07604, KAKENHI-PROJECT-19K16687, KAKENHI-PROJECT-19K16712, KAKENHI-PROJECT-20K16280, KAKENHI-PROJECT-20H03501, KAKENHI-PROJECT-18K07958
[Presentation] (Pro)renin receptor controls immune responses by promoting the survival of naive T and iNKT cells2024
- Author(s)
  宗像悟、榛葉旭恒、生田宏一
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27426
[Presentation] Stress-induced glucocorticoids exacerbate inflammatory diseases by promoting Th17 cell differentiation2024
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27426
[Presentation] グルココルチコイドが制御する免疫の日内変動2024
- Author(s)
  榛葉旭恒
- Organizer
  日本生理人類学会・日本時間生物学会ジョイントセミナー「シフトワークへの適応：生体リズム・睡眠と健康」
- Invited
- Data Source
  KAKENHI-PROJECT-22K07133
[Presentation] Bone marrow microenvironment for NK cell differentiation and localization2024
- Author(s)
  阿部真也、榛葉旭恒、谷一靖江、長澤丘司、生田宏一
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27426
[Presentation] Stress-induced glucocorticoids promote the differentiation of Th17 cells exacerbating inflammatory diseases.2024
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07133
[Presentation] グルココルチコイドが制御するIL-4/IL-17産生を介したがんの増悪機構の解析2023
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  Kyoto T Cell Conference 第31回学術集会
- Data Source
  KAKENHI-PROJECT-23K27426
[Presentation] Lung local IL-7 affect the maintenance, distribution, and activation of ILC2 in allergic airway inflammations2022
- Author(s)
  Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-ichi, Takahiro Hara, and Koichi Ikuta
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03501
[Presentation] ステロイドホルモンによる免疫機能とアレルギーの制御2021
- Author(s)
  生田宏一、榛葉旭恒、江島亜希
- Organizer
  日本アレルギー学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03501
[Presentation] 胎児肝臓に由来する1型自然リンパ球の同定2021
- Author(s)
  旭拓真、阿部真也、崔広為、榛葉旭恒、生田宏一
- Organizer
  Kyoto T Cell Conference 第30回学術集会
- Data Source
  KAKENHI-PROJECT-20H03501
[Presentation] Control of T cell immunity by glucocorticoids2021
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  第28回日本時間生物学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16280
[Presentation] ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる2021
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  Kyoto T Cell Conference 第30回学術集会
- Data Source
  KAKENHI-PROJECT-20K21525
[Presentation] ステロイドホルモンによる免疫機能とアレルギーの制御2021
- Author(s)
  生田宏一、榛葉旭恒、江島亜希
- Organizer
  日本アレルギー学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21525
[Presentation] 胎児肝臓に由来する1型自然リンパ球の同定2021
- Author(s)
  旭拓真、阿部真也、崔広為、榛葉旭恒、生田宏一
- Organizer
  Kyoto T Cell Conference 第30回学術集会
- Data Source
  KAKENHI-PROJECT-20K21525
[Presentation] ストレスはグルココルチコイドを介してTh17細胞を活性化する2021
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  第30回Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-20K16280
[Presentation] ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる2021
- Author(s)
  榛葉旭恒、生田宏一
- Organizer
  Kyoto T Cell Conference 第30回学術集会
- Data Source
  KAKENHI-PROJECT-20H03501
[Presentation] Glucocorticoids enhance T cell immune response.2019
- Author(s)
  榛葉旭恒
- Organizer
  日本免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15184
[Presentation] Control of immunity by glucocorticoids2019
- Author(s)
  Shimba Akihiro
- Organizer
  第４８回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15184

1. IKUTA Koichi (90193177)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 崔广為 (70791276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 谷一靖江 (50432331)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 阿部真也 (70972678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 若村智子 (40240452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中本五鈴 (30966966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 福田裕美 (50551412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高雄元晴 (90408013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高江洲義和 (90421015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 八木田和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山田真太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 宮内栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimba Akihiro 榛葉 旭恒

Research Projects

Research Products

Co-Researchers

リソソーム機能の概日リズムがCD8T細胞の抗がん免疫応答を制御する機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of nighttime lighting to promote patient sleep under metameric conditions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ストレスがTH17細胞のプロテアーゼの発現上昇と関節炎増悪に寄与する機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Induction of autoimmune diseases by glucocorticoids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stress-induced renin causes intestinal inflammation via helper T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Glucocorticoids enhance the differentiation and function of Th17 cells and cause colitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A circulating subset of iNKT cells mediates antitumor and antiviral immunity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks2022

Author(s)

Journal Title

Shimba Akihiro 榛葉旭恒

[Presentation] グルココルチコイドが制御する免疫の日内変動2024