Otani Yoshinori 大谷嘉典

Researcher Number	30815973
Other IDs	https://orcid.org/0000-0002-3214-4637
Affiliation (Current)	2026: 島根大学, 学術研究院医学・看護学系, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 島根大学, 学術研究院医学・看護学系, 助教 2019 – 2020: 島根大学, 学術研究院医学・看護学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator ミエリン / オリゴデンドロサイト / オリゴデンドロサイト前駆細胞 / アンジェルマン症候群 / 難病 / node of Ranvier / Angelman syndrome / AIS / para-AIS / Myelin … More / axon initial segment / OPC / oligodendrocyte / myelin / 髄鞘 / パラ軸索起始部 / 軸索起始部 / UBE3A / readthrough / シュワン細胞 / CMT disease / 翻訳リードスルー / myelin protein Zero / シャルコー・マリー・トゥース病 / リードスルー / L-MPZ … More Except Principal Investigator 脂肪酸代謝異常症 / 低ホスファターぜ症 / ミトコドリア / 間葉系幹細胞 / 先天代謝異常症 / ミトコンドリア病 / 低ホスファターゼ症 / 高純度間葉系幹細胞 Less

Functional Analysis of Oligodendrocytes Involved in the Pathophysiology of Angelman Syndrome.Principal Investigator
- Principal Investigator
  
  大谷嘉典
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Highly Purified Mesenchymal Stem Cell Therapy for Neuropathy of Congenital Metabolic Disorders Involved on Mitochondria
- Principal Investigator
  
  竹谷健
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Interaction of Myelin-Axon reveled new pathological mechanism in angelman syndromePrincipal Investigator
- Principal Investigator
  
  Otani Yoshinori
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shimane University
Increased ratio of large myelin protein zero (L-MPZ) in myelin leads to Charcot-Marie-Tooth disease-like neuropathyPrincipal Investigator
- Principal Investigator
  
  Otani Yoshinori
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Shimane University

All 2025 2024 2023 2020 2019

All Journal Article Presentation

[Journal Article] UBE3A controls axon initial segment in the cortical pyramidal neurons2025
- Author(s)
  Liu Xinlang、Jiang Zhuqian、Otani Yoshinori、Zhu Xiaowei、Yu Yanyan、Tarif Abu Md Mamun、Ferdousy Raihana Nasrin、Kishino Tatsuya、Fujitani Masashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 751 Pages: 151429-151429
- DOI
  10.1016/j.bbrc.2025.151429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07848, KAKENHI-PROJECT-22K07868, KAKENHI-PROJECT-23K07290
[Journal Article] MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC)2023
- Author(s)
  Liu Lu、Yang Jiahao、Otani Yoshinori、Shiga Takahiro、Yamaguchi Akihiro、Oda Yasuaki、Hattori Miho、Goto Tsukimi、Ishibashi Shuichi、Kawashima-Sonoyama Yuki、Ishihara Takaya、Matsuzaki Yumi、Akamatsu Wado、Fujitani Masashi、Taketani Takeshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17186-17186
- DOI
  10.3390/ijms242417186
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07267, KAKENHI-PROJECT-23K07290, KAKENHI-PROJECT-21K06066, KAKENHI-PROJECT-22KJ2745, KAKENHI-PROJECT-21H02814, KAKENHI-PROJECT-23K27567
[Journal Article] Upregulation of large myelin protein zero leads to CharcotーMarieーTooth disease-like neuropathy in mice2020
- Author(s)
  Otani Yoshinori、Ohno Nobuhiko、Cui Jingjing、Yamaguchi Yoshihide、Baba Hiroko
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 121-121
- DOI
  10.1038/s42003-020-0854-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19K16267, KAKENHI-PROJECT-16H06280
[Presentation] UBE3A deficiency in oligodendrocyte precursor cells causes abnormal myelination.2024
- Author(s)
  Yoshinori Otani, Liu Xinlang, Masashi Fujitani.
- Organizer
  APPW2025第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会　合同大会2025年3月
- Data Source
  KAKENHI-PROJECT-22K07868
[Presentation] MELAS-derived neuron functionally improve by mitochondrial transfer from Rapidly Expanding Cell, REC2024
- Author(s)
  LU LIU, Jiahao Yang, Yoshinori Otani, Takahiro Shiga, Akihiro Yamaguchi, Yumi Matsuzaki, Wado Akamatsu, Masashi Fujitani, Takeshi Taketani
- Organizer
  第23回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-23K27567
[Presentation] Ube3a deficiency in oligodendrocyte precursor cells (OPCs) leads to abnormal myelination.2024
- Author(s)
  Xinlang Liu, Yoshinori Otani, Masashi Fujitani.
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07868
[Presentation] UBE3A deficiency causes abnormal differentiation in oligodendrocyte precursor cells (OPCs).2023
- Author(s)
  Liu Xinlang, Yoshinori Otani, Masashi Fujitani
- Organizer
  Japan Neuroscience Society 2023
- Data Source
  KAKENHI-PROJECT-22K07868
[Presentation] UBE3A deficiency in oligodendrocyte lineage cells causes abnormal myelination.2023
- Author(s)
  Yoshinori Otani, Liu Xinlang, Masashi Fujitani
- Organizer
  第129回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-22K07868
[Presentation] Alteration of neural activity in the layer V pyramidal neuron of prelimbic cortex in ASD model mouse.2023
- Author(s)
  Yoshinori Otani, Kohei Koga, Xinglang Liu, Masashi Fujitani
- Organizer
  17th Meeting of the Asia-Pacific Society for Neurochemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07868
[Presentation] Progressive pathology in Charcot-Marie-Tooth (CMT) disease model, L-MPZ mouse2020
- Author(s)
  ○Yoshinori Otani, Yoshihide Yamaguchi, Jing-Jing Cui, Kanako Aigo, Ayaka Hara, Gouta Ban, Masashi Fujitani, Hiroko Baba
- Organizer
  第63回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-19K16267
[Presentation] 末梢神経機能に影響を及ぼす翻訳リードスルータンパク質Large myelin protein zeroの解析2020
- Author(s)
  大谷嘉典, 大野伸彦 , 山口宜秀, 崔晶晶, 藤谷昌司, 馬場広子
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K16267
[Presentation] 翻訳リードスルーにより制御されるミエリンの形成と機能2019
- Author(s)
  大谷嘉典,大野伸彦 ,山口宜秀,　崔晶晶,　馬場広子
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19K16267
[Presentation] Increased ratio of large myelin protein zero (L-MPZ) in myelin leads to Charcot-Marie-Tooth disease-like neuropathy2019
- Author(s)
  Yoshinori Otani, Nobuhiko Ohno, Yoshihide Yamaguchi, Jing-Jing Cui, Hiroko Baba
- Organizer
  The 2019 ISN-ASN Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16267

1. 古賀浩平 (50768455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 竹谷健 (30359880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 藤谷昌司 (40376372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 松崎有未 (50338183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 赤松和土 (60338184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 山田健治 (70624930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 木住野達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小田泰昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山口宜秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otani Yoshinori 大谷 嘉典

Research Projects

Research Products

Co-Researchers

Functional Analysis of Oligodendrocytes Involved in the Pathophysiology of Angelman Syndrome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Highly Purified Mesenchymal Stem Cell Therapy for Neuropathy of Congenital Metabolic Disorders Involved on Mitochondria

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interaction of Myelin-Axon reveled new pathological mechanism in angelman syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Increased ratio of large myelin protein zero (L-MPZ) in myelin leads to Charcot-Marie-Tooth disease-like neuropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] UBE3A controls axon initial segment in the cortical pyramidal neurons2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC)2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of large myelin protein zero leads to CharcotーMarieーTooth disease-like neuropathy in mice2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] UBE3A deficiency in oligodendrocyte precursor cells causes abnormal myelination.2024

Author(s)

Organizer

Data Source

[Presentation] MELAS-derived neuron functionally improve by mitochondrial transfer from Rapidly Expanding Cell, REC2024

Author(s)

Organizer

Data Source

[Presentation] Ube3a deficiency in oligodendrocyte precursor cells (OPCs) leads to abnormal myelination.2024

Author(s)

Organizer

Data Source

[Presentation] UBE3A deficiency causes abnormal differentiation in oligodendrocyte precursor cells (OPCs).2023

Author(s)

Organizer

Data Source

[Presentation] UBE3A deficiency in oligodendrocyte lineage cells causes abnormal myelination.2023

Author(s)

Organizer

Data Source

[Presentation] Alteration of neural activity in the layer V pyramidal neuron of prelimbic cortex in ASD model mouse.2023

Author(s)

Organizer

Data Source

[Presentation] Progressive pathology in Charcot-Marie-Tooth (CMT) disease model, L-MPZ mouse2020

Author(s)

Organizer

Data Source

[Presentation] 末梢神経機能に影響を及ぼす翻訳リードスルータンパク質Large myelin protein zeroの解析2020

Author(s)

Organizer

Data Source

[Presentation] 翻訳リードスルーにより制御されるミエリンの形成と機能2019

Author(s)

Organizer

Data Source

[Presentation] Increased ratio of large myelin protein zero (L-MPZ) in myelin leads to Charcot-Marie-Tooth disease-like neuropathy2019

Otani Yoshinori 大谷嘉典