shimizu nobuyuki 清水誠之

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Shimizu Nobuyuki 清水誠之

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Researcher Number	30817143
Other IDs	https://orcid.org/0000-0002-8100-0330
Affiliation (Current)	2024: 大分大学, 医学部, 助教 2024: 東京医科大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2023: 大分大学, 医学部, 助教 2020: 大分大学, 医学部, 助教 2019: 東京医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator ゼブラフィッシュXLMTMモデル / ライトシート型超解像顕微鏡 / 生体ライブイメージング / 重度肝障害 / ＭＴＭ１遺伝子 / 疾患モデル動物 / イメージング解析 / 肝障害 / MTM1遺伝子 / X連鎖性ミオチュブラーミオパチー … More / 急性前骨髄球性白血病（APL) / 急性前骨髄急性白血病（APL） / タンパク質分解誘導 / セレブロンモジュレーター / セレブロン（CRBN) / 急性前骨髄球性白血病 / ポマリドマイド / レナリドマイド / セレブロン / 急性前骨髄球性白血病（APL） / 融合遺伝子 / ネオ基質 / ポマリドミド / レナリドミド / サリドマイド / E3ユビキチンリガーゼ / セレブロン（CRBN） Less

X連鎖性ミオチュブラーミオパチーに合併する肝紫斑病の病態メカニズムの解明Principal Investigator
- Principal Investigator
  
  清水誠之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Oita University
Elucidation of the mechanism of action of cereblon modulators on acute promyelocytic leukemia (APL)Principal Investigator
- Principal Investigator
  
  Shimizu Nobuyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Oita University
  Tokyo Medical University

All 2024 2023 2020

All Journal Article Presentation

[Journal Article] Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model2024
- Author(s)
  Sebastian Wulan Apridita、Inoue Masanori、Shimizu Nobuyuki、Sato Ryosuke、Oguri Saori、Itonaga Tomoyo、Kishimoto Shintaro、Shiraishi Hiroshi、Hanada Toshikatsu、Ihara Kenji
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 69 Issue: 3-4 Pages: 133-138
- DOI
  10.1038/s10038-024-01221-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-20H03644
[Journal Article] Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease2024
- Author(s)
  Tokumaru Tomoko、Apolinario Magdeline E. Carrasco、Shimizu Nobuyuki、Umeda Ryohei、Honda Koichi、Shikano Kenshiro、Teranishi Hitoshi、Hikida Takatoshi、Hanada Toshikatsu、Ohta Keisuke、Li Yulong、Murakami Kazunari、Hanada Reiko
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 7813-7813
- DOI
  10.1038/s41598-024-58043-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15396, KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-23K07418, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-23K21629
[Journal Article] DHCR7 links cholesterol synthesis with neuronal development and axonal integrity2024
- Author(s)
  Miyazaki Shuya、Shimizu Nobuyuki、Miyahara Hiroaki、Teranishi Hitoshi、Umeda Ryohei、Yano Shinji、Shimada Tatsuo、Shiraishi Hiroshi、Komiya Kosaku、Katoh Akira、Yoshimura Akihiko、Hanada Reiko、Hanada Toshikatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 712-713 Pages: 149932-149932
- DOI
  10.1016/j.bbrc.2024.149932
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-23K21629
[Journal Article] A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish2024
- Author(s)
  Ikeuchi Mayo、Inoue Masanori、Miyahara Hiroaki、Sebastian Wulan Apridita、Miyazaki Shuya、Takeno Takashi、Kiyota Kyoko、Yano Shinji、Shiraishi Hiroshi、Shimizu Nobuyuki、Hanada Reiko、Yoshimura Akihiko、Ihara Kenji、Hanada Toshikatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 699 Pages: 149551-149551
- DOI
  10.1016/j.bbrc.2024.149551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-21K06871, KAKENHI-PROJECT-21K07756, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-23K21629
[Journal Article] Behavioral and neurological effects of Vrk1 deficiency in zebrafish2023
- Author(s)
  Carrasco Apolinario Magdeline E.、Umeda Ryohei、Teranishi Hitoshi、Shan Mengting、Phurpa、Sebastian Wulan Apridita、Lai Shaohong、Shimizu Nobuyuki、Shiraishi Hiroshi、Shikano Kenshiro、Hikida Takatoshi、Hanada Toshikatsu、Ohta Keisuke、Hanada Reiko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 675 Pages: 10-18
- DOI
  10.1016/j.bbrc.2023.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15396, KAKENHI-PROJECT-23K06329, KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-23K10800, KAKENHI-PROJECT-20K06730, KAKENHI-PROJECT-21K06871, KAKENHI-PROJECT-22K20742, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-23K21629
[Journal Article] Zebrafish as a Useful Model System for Human Liver Disease2023
- Author(s)
  Shimizu Nobuyuki、Shiraishi Hiroshi、Hanada Toshikatsu
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 18 Pages: 2246-2246
- DOI
  10.3390/cells12182246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07336, KAKENHI-PROJECT-21K06871, KAKENHI-PROJECT-20H03644
[Journal Article] ARID2 is a pomalidomide-dependent CRL4 CRBN substrate in multiple myeloma cells2020
- Author(s)
  Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
- Journal Title
  
  Nat Chem Biol
  
  Volume: 16 Issue: 11 Pages: 1208-1217
- DOI
  10.1038/s41589-020-0645-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07396, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20H03182, KAKENHI-PROJECT-19K16378
[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の病態メカニズム2024
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の分子メカニズムの解明2023
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] タンパク質分解システムの破綻に起因する疾患の分子機構解明とその制御2023
- Author(s)
  清水誠之
- Organizer
  令和５年度日本生化学会九州支部
- Invited
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] ナンセンス変異依存mRNA分解機構の制御破綻が早期老化を誘導する2023
- Author(s)
  白石裕士, Lai Shaohong, Sebastian Wulan, Wang Honxia, 清水誠之, 花田礼子, 花田俊勝
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] ゼブラフィッシュモデルでみるSLOS脳病変のin vivo解析2023
- Author(s)
  宮崎周也, 池内真代, 竹野貴志, 清田今日子, Lai Shaohong, 清水誠之, 白石裕士, 花田俊勝
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K07336
[Presentation] ゼブラフィッシュイメージングを用いたX連鎖性ミオチュブラーミオパチーに合併する重度肝障害の病態機構解明2023
- Author(s)
  清水誠之, 白石裕士, 井上真紀, 清田今日子, 井原健二, 花田俊勝
- Organizer
  第13回癌・炎症と抗酸化研究会プログラム（CIA研究会）
- Data Source
  KAKENHI-PROJECT-23K07336

1. 井上真紀 (20726913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 鹿野健史朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 百瀬修二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

shimizu nobuyuki 清水 誠之

Shimizu Nobuyuki 清水 誠之

Research Projects

Research Products

Co-Researchers

X連鎖性ミオチュブラーミオパチーに合併する肝紫斑病の病態メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of action of cereblon modulators on acute promyelocytic leukemia (APL)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic steatotic liver disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DHCR7 links cholesterol synthesis with neuronal development and axonal integrity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Behavioral and neurological effects of Vrk1 deficiency in zebrafish2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zebrafish as a Useful Model System for Human Liver Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ARID2 is a pomalidomide-dependent CRL4 CRBN substrate in multiple myeloma cells2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の病態メカニズム2024

Author(s)

Organizer

Data Source

[Presentation] X連鎖性ミオチュブラーミオパチーに伴う重度肝障害の分子メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] タンパク質分解システムの破綻に起因する疾患の分子機構解明とその制御2023

Author(s)

Organizer

Data Source

[Presentation] ナンセンス変異依存mRNA分解機構の制御破綻が早期老化を誘導する2023

Author(s)

Organizer

Data Source

[Presentation] ゼブラフィッシュモデルでみるSLOS脳病変のin vivo解析2023

Author(s)

Organizer

Data Source

[Presentation] ゼブラフィッシュイメージングを用いたX連鎖性ミオチュブラーミオパチーに合併する重度肝障害の病態機構解明2023

Author(s)

Organizer

Data Source

shimizu nobuyuki 清水誠之

Shimizu Nobuyuki 清水誠之