Koyama Takafumi 小山隆文

… Alternative Names

小山隆文コヤマタカフミ

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Researcher Number	30828538
Affiliation (Current)	2026: 国立研究開発法人国立がん研究センター, 中央病院, 医長
Affiliation (based on the past Project Information) *help	2026: 国立研究開発法人国立がん研究センター, 中央病院, 医長 2022 – 2024: 国立研究開発法人国立がん研究センター, 中央病院, 医長 2020 – 2021: 国立研究開発法人国立がん研究センター, 中央病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 58:Society medicine, nursing, and related fields
Keywords	Principal Investigator 耐性機序 / モデル化 / バイオマーカー / 野生型TP53 / MDM2増幅 / HPD / PDX / 内膜肉腫 / TP53 / MDM2 … More Except Principal Investigator … More 抗体医薬による輸注反応（IRR) / 抗体薬物複合体 / サイトカインプロファイル / 新規抗体医薬 / サイトカイン / IRR / がん新薬早期開発 / 患者－医師間コミュニケーション / ソーシャルサポート / 不安 / うつ / 心理的影響 / がん遺伝子検査パネル Less

循環腫瘍細胞由来オルガノイドを用いた抗悪性腫瘍薬耐性メカニズムを解明する研究Principal Investigator
- Principal Investigator
  
  小山隆文
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
進行癌に対する次世代抗体薬投与時サイトカインプロファイル緊急網羅的解析モデル探索
- Principal Investigator
  
  清水俊雄
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kansai Medical University
  Wakayama Medical University
Fundamental research on biomarkers and Immunological response for solid tumors harboring MDM2 amplificationPrincipal Investigator
- Principal Investigator
  
  小山隆文
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Psychosocial Impact of Cancer Gene Panel Test
- Principal Investigator
  
  Uchitomi Yosuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  National Cancer Center Japan

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Genomic profiles of Japanese patients with vulvar squamous cell carcinoma2024
- Author(s)
  Fujii Erisa、Kato Mayumi Kobayashi、Yamaguchi Maiko、Higuchi Daiki、Koyama Takafumi、Komatsu Masaaki、Hamamoto Ryuji、Ishikawa Mitsuya、Kato Tomoyasu、Kohno Takashi、Shiraishi Kouya、Yoshida Hiroshi
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41598-024-63913-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] Identification of barriers to implementation of precision oncology in patients with rare cancers.2024
- Author(s)
  Takamizawa S, Koyama T, Sunami K, Sudo K, Hirata M, Kubo T, Tao K, Cho H, Narita Y, Kato K, Yamazaki N, Ohe Y, Okusaka T, Matsui Y, Ogawa C, Yonemori K, Yamamoto N.
- Journal Title
  
  Cancer Sci.
  
  Volume: Online ahead of print. Issue: 6 Pages: 2023-2035
- DOI
  10.1111/cas.16165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24468, KAKENHI-PROJECT-22K15614
[Journal Article] The impact of rare cancer and early-line treatments on the benefit of comprehensive genome profiling-based precision oncology2024
- Author(s)
  Kubo T.、Sunami K.、Koyama T. et.al
- Journal Title
  
  ESMO Open
  
  Volume: 9 Issue: 4 Pages: 102981-102981
- DOI
  10.1016/j.esmoop.2024.102981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence2024
- Author(s)
  Sunami Kuniko、Naito Yoichi、Koyama Takafumi et.al
- Journal Title
  
  JAMA Oncology
  
  Volume: 10 Issue: 1 Pages: 95-95
- DOI
  10.1001/jamaoncol.2023.5120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-21H02795
[Journal Article] Phase I Study of Simlukafusp Alfa (FAP-IL2v) with or without Atezolizumab in Japanese Patients with Advanced Solid Tumors2024
- Author(s)
  Koyama Takafumi、Yonemori Kan、Shimizu Toshio、Sato Jun、Kondo Shunsuke、Sudo Kazuki、Yoshida Tatsuya、Katsuya Yuki、Imaizumi Tatsuki、Enomoto Masashi、Seki Ryoko、Yamamoto Noboru
- Journal Title
  
  Cancer Research Communications
  
  Volume: 4 Issue: 9 Pages: 2349-2358
- DOI
  10.1158/2767-9764.crc-24-0185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma2024
- Author(s)
  Shirai Y, Ueno T, Kojima S, Ikeuchi H, Kitada R, Koyama T, Takahashi F, Takahashi K, Ichimura K, Yoshida A, Sugino H, Mano H, Narita Y, Takahashi M, Kohsaka S
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 167 Issue: 1 Pages: 75-88
- DOI
  10.1007/s11060-024-04563-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-22K15614
[Journal Article] Travel Time and Distance and Participation in Precision Oncology Trials at the National Cancer Center Hospital2023
- Author(s)
  Uehara Yuji、Koyama Takafumi、Katsuya Yuki、Sato Jun、Sudo Kazuki、Kondo Shunsuke、Yoshida Tatsuya、Shoji Hirokazu、Shimoi Tatsunori、Yonemori Kan、Yamamoto Noboru
- Journal Title
  
  JAMA Network Open
  
  Volume: 6 Issue: 9 Pages: e2333188-e2333188
- DOI
  10.1001/jamanetworkopen.2023.33188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with <i>MDM2</i> Amplification: An Open-Label Phase Ib/II Study2023
- Author(s)
  Koyama Takafumi、Shimizu Toshio、Kojima Yuki、Sudo Kazuki、Okuma Hitomi Sumiyoshi、Shimoi Tatsunori、Ichikawa Hitoshi、Kohsaka Shinji、Sadachi Ryo、Hirakawa Akihiro、Yoshida Akihiko、Ando Reiko Makihara、Ueno Toshihide、Yanagaki Mitsuru、Matsui Naoko、Nakamura Kenichi、Yamamoto Noboru、Yonemori Kan
- Journal Title
  
  Cancer Discovery
  
  Volume: 13 Issue: 8 Pages: 1814-1825
- DOI
  10.1158/2159-8290.cd-23-0419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-20K11703, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-21H03062
[Journal Article] Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer2023
- Author(s)
  Asami Y, Kobayshi Kato M, Shiraishi K, Yoshida H
- Journal Title
  
  Br J Cancer
  
  Volume: 128 Issue: 8 Pages: 1582-1591
- DOI
  10.1038/s41416-023-02203-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16891, KAKENHI-PROJECT-19K16572, KAKENHI-PROJECT-22K15614
[Journal Article] First-in-human study of ONO-4578, an antagonist of prostaglandin E2 receptor 4, alone and with nivolumab in solid tumors2022
- Author(s)
  Iwasa Satoru、Koyama Takafumi、Nishino Makoto、Kondo Shunsuke、Sudo Kazuki、Yonemori Kan、Yoshida Tatsuya、Tamura Kenji、Shimizu Toshio、Fujiwara Yutaka、Kitano Shigehisa、Shimomura Akihiko、Sato Jun、Yokoyama Fumiharu、Iida Hiroyuki、Kondo Maki、Yamamoto Noboru
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 211-220
- DOI
  10.1111/cas.15574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors2022
- Author(s)
  Sato Jun、Shimizu Toshio、Koyama Takafumi、Iwasa Satoru、Shimomura Akihiko、Kondo Shunsuke、Kitano Shigehisa、Yonemori Kan、Fujiwara Yutaka、Tamura Kenji、Suzuki Takuya、Takase Takao、Nagai Reiko、Yamaguchi Kohei、Semba Taro、Zhao Zi-Ming、Ren Min、Yamamoto Noboru
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 28 Issue: 9 Pages: 1783-1791
- DOI
  10.1158/1078-0432.ccr-21-3518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] Clinical utility of comprehensive genomic profiling tests for advanced or metastatic solid tumor in clinical practice2022
- Author(s)
  Ida Hanae、Koyama Takafumi、Mizuno Takaaki、Sunami Kuniko、Kubo Takashi、Sudo Kazuki、Tao Kayoko、Hirata Makoto、Yonemori Kan、Kato Ken、Okusaka Takuji、Ohe Yuichiro、Matsui Yoshiyuki、Yamazaki Naoya、Ogawa Chitose、Kawai Akira、Narita Yoshitaka、Esaki Minoru、Yamamoto Noboru
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4300-4310
- DOI
  10.1111/cas.15586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614, KAKENHI-PROJECT-23K24468
[Journal Article] Practical consideration for successful sequential tumor biopsies in first-in-human trials2022
- Author(s)
  Koyama Takafumi、Shimizu Toshio、Sato Jun、Katsuya Yuki、Iwasa Satoru、Kondo Shunsuke、Yoshida Tatsuya、Sudo Kazuki、Nishino Makoto、Takiguchi Yuichi、Yonemori Kan、Yamamoto Noboru
- Journal Title
  
  Investigational New Drugs
  
  Volume: 40 Issue: 4 Pages: 841-849
- DOI
  10.1007/s10637-022-01236-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15614
[Journal Article] Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody?drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors2022
- Author(s)
  Rottey Sylvie、Clarke Jeffrey、Aung Kyaw、Machiels Jean-Pascal、Markman Ben、Heinhuis Kimberley M.、Millward Michael、Lolkema Martijn、Patel Sandip Pravin、de Souza Paul、Duca Matteo、Curigliano Giuseppe、Santoro Armando、Koyama Takafumi、Brown Michelle、Vezina Heather、He Chunsheng、Chu Quincy Siu-Chung
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 28 Issue: 1 Pages: 95-105
- DOI
  10.1158/1078-0432.ccr-21-1181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15614
[Presentation] MDM2 Amplified Tumor.2023
- Author(s)
  Takafumi Koyama
- Organizer
  21st Annual Meeting of the Japan Society of Medical Oncology
- Invited
- Data Source
  KAKENHI-PROJECT-22K15614
[Presentation] Exploratory novel biomarker and resistance mechanism of milademetan, an MDM2 inhibitor, in MDM2 amplified intimal sarcoma from an open-label phase 1b/2 trial (NCCH1806/MK004) .2023
- Author(s)
  Takafumi Koyama
- Organizer
  Annual Meeting of the Amrican Society of Medical Oncology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15614
[Presentation] Clinical Utility of Comprehensive Genomic Profiling Tests for Advanced or Metastatic Solid Tumor under the Japanese National Health Insurance System2022
- Author(s)
  Takafumi Koyama
- Organizer
  第20回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15614

1. Uchitomi Yosuke (60243565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 白井由紀 (30587382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤森麻衣子 (40450572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 清水俊雄 (30411599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉田達哉 (10729338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 勝屋友幾 (40752704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 渡邊慶介 (60847466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本昇 (80501874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 洪泰浩 (80426519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平田真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 加藤真弓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 高阪真路

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koyama Takafumi 小山 隆文

小山 隆文 コヤマ タカフミ

Research Projects

Research Products

Co-Researchers

循環腫瘍細胞由来オルガノイドを用いた抗悪性腫瘍薬耐性メカニズムを解明する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

進行癌に対する次世代抗体薬投与時サイトカインプロファイル緊急網羅的解析モデル探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research on biomarkers and Immunological response for solid tumors harboring MDM2 amplificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Psychosocial Impact of Cancer Gene Panel Test

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Genomic profiles of Japanese patients with vulvar squamous cell carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of barriers to implementation of precision oncology in patients with rare cancers.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of rare cancer and early-line treatments on the benefit of comprehensive genome profiling-based precision oncology2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Learning Program for Treatment Recommendations by Molecular Tumor Boards and Artificial Intelligence2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase I Study of Simlukafusp Alfa (FAP-IL2v) with or without Atezolizumab in Japanese Patients with Advanced Solid Tumors2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Travel Time and Distance and Participation in Precision Oncology Trials at the National Cancer Center Hospital2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with <i>MDM2</i> Amplification: An Open-Label Phase Ib/II Study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] First-in-human study of ONO-4578, an antagonist of prostaglandin E2 receptor 4, alone and with nivolumab in solid tumors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors2022

Koyama Takafumi 小山隆文

小山隆文コヤマタカフミ