KOU Yasuhiro 洪泰浩

Researcher Number	80426519
Affiliation (Current)	2022: 和歌山県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 和歌山県立医科大学, 医学部, 准教授 2014 – 2016: 和歌山県立医科大学, 医学部, 講師 2015: 和歌山県立医科大学, 内科学第3講座, 講師 2013: 静岡県立静岡がんセンター(研究所), その他部局等, その他 2012: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2012: 静岡県立静岡がんセンター(研究所), 新規薬剤開発・評価研究部, 部長
Review Section/Research Field	Principal Investigator Clinical oncology / Tumor therapeutics / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Respiratory organ internal medicine / Tumor biology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Tumor therapeutics / Tumor diagnostics / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 分子標的治療 / チロシンキナーゼ / スキルス胃がん / 肺がん / 悪性胸膜中皮腫 / VHL変異 / がん個別化医療 / HIF-1 Except Principal Investigator 肺癌 / 肺がん … More

KRAS変異陽性肺がんにおける次世代個別化医療の実現へ向けた基盤研究Principal Investigator
- Principal Investigator
  
  洪泰浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Wakayama Medical University
Elucidation of synergistic mechanisms in the combination of chemotherapy and PD-1/L1 inhibitors and exploration for novel therapeutic targets
- Principal Investigator
  
  小澤雄一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Wakayama Medical University
AXLを標的とした肺がん個別化医療実現に向けた基盤研究
- Principal Investigator
  
  山本信之
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Wakayama Medical University
Impact of tumor heterogeneity of driver mutation-positive lung cancer
- Principal Investigator
  
  Hiroaki Akamtsu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Wakayama Medical University
Mutational analysis on carcinogenesis in multiple primary lung cancers
- Principal Investigator
  
  Kawaguchi Tomoya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka City University
Genome-wide analysis for the cure of advanced lung cancer
- Principal Investigator
  
  Kubo Akihito
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Aichi Medical University
Development of VHL-targeted therapy in malignant pleural mesotheliomaPrincipal Investigator
- Principal Investigator
  
  Koh Yasuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Wakayama Medical University
Multiplex mutation detection using digital PCR method and its clinical utility
- Principal Investigator
  
  Yamamoto Nobuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Wakayama Medical University
Exploratory analyses of comprehensive and quantitative mutation profiling using cell-free DNA
- Principal Investigator
  
  Akamatsu Hiroaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
  Tumor diagnostics
- Research Institution
  Wakayama Medical University
Cancer therapeutic target identification by comprehensive kinase profilingPrincipal Investigator
- Principal Investigator
  
  KOH Yasuhiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Wakayama Medical University
  Shizuoka Cancer Center Research Institute
Molecular profiling and biomarker study of thoracic malignancies
- Principal Investigator
  
  YAMAMOTO Nobuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Wakayama Medical University
  Shizuoka Cancer Center Research Institute
Nobel pharmacodynamics evaluation of molecular targeting agents: PHarmacokinetic/PHarmacodynamic Assessment on Malignant Effusions (PHAME)
- Principal Investigator
  
  KUBO Akihito
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Aichi Medical University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] リキッドバイオプシー―体液中腫瘍マーカーの検出・解析技術―2017
- Author(s)
  洪泰浩
- Total Pages
  8
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15K06878
[Book] デジタルPCRの原理と臨床腫瘍学での有用性2016
- Author(s)
  赤松弘朗, 洪泰浩, 山本信之
- Total Pages
  5
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15K09226
[Book] 新臨床腫瘍学2015
- Author(s)
  洪　泰浩
- Total Pages
  4
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-15K06878
[Book] バイオマーカーとしての薬剤投与後のキナーゼ活性の変化2015
- Author(s)
  洪　泰浩
- Total Pages
  6
- Publisher
  メディカルレビュー
- Data Source
  KAKENHI-PROJECT-15K06878
[Book] がん分子標的治療　腫瘍の遺伝子情報の臨床への応用2014
- Author(s)
  洪　泰浩
- Total Pages
  115
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-24501363
[Journal Article] Phase Ib Study of Osimertinib Plus Ramucirumab in Japanese Lung Cancer Patients With EGFR Mutation2021
- Author(s)
  AKAMATSU HIROAKI、OZAWA YUICHI、OYANAGI JUN、FUJIMOTO DAICHI、HATA AKITO、KATAKAMI NOBUYUKI、TOMII KEISUKE、MURAKAMI ERIKO、SUGIMOTO TAKEYA、SHIMOKAWA TOSHIO、KOH YASUHIRO、YAMAMOTO NOBUYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Pages: 911-917
- DOI
  10.21873/anticanres.14844
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Clinical Characteristics of Rapidly Progressive Fatal Hemorrhagic Pneumonia Caused by <i>Stenotrophomonas maltophilia</i>2020
- Author(s)
  Imoto Waki、Yamada Koichi、Yamairi Kazushi、Shibata Wataru、Namikawa Hiroki、Yukawa Satomi、Yoshii Naoko、Nakaie Kiyotaka、Hirose Asao、Koh Hideo、Watanabe Tetsuya、Asai Kazuhisa、Nakamae Hirohisa、Kaneko Yukihiro、Kawaguchi Tomoya、Hino Masayuki、Kakeya Hiroshi
- Journal Title
  
  Internal Medicine
  
  Volume: 59 Issue: 2 Pages: 193-198
- DOI
  10.2169/internalmedicine.3358-19
- NAID
  130007785083
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07176
[Journal Article] CD24, not CD47, negatively impacts upon response to PD‐1/L1 inhibitors in non?small‐cell lung cancer with PD‐L1 tumor proportion score?<?502020
- Author(s)
  Ozawa Yuichi、Harutani Yuhei、Oyanagi Jun、Akamatsu Hiroaki、Fukuoka Junya、Nakanishi Masanori、Koh Yasuhiro、Yamamoto Nobuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 112 Pages: 72-80
- DOI
  10.1111/cas.14705
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Differential significance of molecular subtypes which were classified into EGFR exon 19 deletion on the first line afatinib monotherapy2020
- Author(s)
  Tokudome Nahomi、Koh Yasuhiro、Akamatsu Hiroaki、Fujimoto Daichi、Okamoto Isamu、Nakagawa Kazuhiko、Hida Toyoaki、Imamura Fumio、Morita Satoshi、Yamamoto Nobuyuki
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Pages: 103-103
- DOI
  10.1186/s12885-020-6593-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Detection of AXL expression in circulating tumor cells of lung cancer patients using an automated microcavity array system2020
- Author(s)
  Ikeda Mio、Koh Yasuhiro、Teraoka Shunsuke、Sato Koichi、Kanai Kuninobu、Hayata Atsushi、Tokudome Nahomi、Akamatsu Hiroaki、Ozawa Yuichi、Akamatsu Keiichiro、Endo Katsuya、Higuchi Masayuki、Nakanishi Masanori、Ueda Hiroki、Yamamoto Nobuyuki
- Journal Title
  
  Cancer Medicine
  
  Volume: 9 Pages: 2122-2133
- DOI
  10.1002/cam4.2846
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Impact of somatic mutations on prognosis in resected non‐small‐cell lung cancer: The Japan Molecular Epidemiology for lung cancer study2020
- Author(s)
  Tamiya Akihiro、Koh Yasuhiro、Isa Shun‐ichi、Kubo Akihito、Ando Masahiko、Saka Hideo、Yoshimoto Naoki、Takeo Sadanori、Adachi Hirofumi、Tagawa Tsutomu、Kawashima Osamu、Yamashita Motohiro、Kataoka Kazuhiko、Takenoyama Mitsuhiro、Takeuchi Yukiyasu、Watanabe Katsuya、Matsumura Akihide、Kawaguchi Tomoya
- Journal Title
  
  Cancer Medicine
  
  Volume: 9 Pages: 2343-2351
- DOI
  10.1002/cam4.2897
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07128, KAKENHI-PROJECT-17K07176, KAKENHI-PROJECT-18K07443
[Journal Article] Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors2020
- Author(s)
  Matsumoto Yoshiya、Sawa Kenji、Fukui Mitsuru、Oyanagi Jun、Yoshimoto Naoki、Suzumura Tomohiro、Watanabe Tetsuya、Kaneda Hiroyasu、Mitsuoka Shigeki、Asai Kazuhisa、Kimura Tatsuo、Yamamoto Nobuyuki、Hirata Kazuto、Koh Yasuhiro、Kawaguchi Tomoya
- Journal Title
  
  Lung Cancer
  
  Volume: 139 Pages: 80-88
- DOI
  10.1016/j.lungcan.2019.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07176
[Journal Article] The impact of high PD-L1 expression on the surrogate endpoints and clinical outcomes of anti-PD-1/PD-L1 antibodies in non-small cell lung cancer2019
- Author(s)
  Ito K, Miura S, Sakaguchi T, Murotani K, Horita N, Akamatsu H, Uemura K, Morita S, Yamamoto N.
- Journal Title
  
  Lung Cancer
  
  Volume: 128 Pages: 113-119
- DOI
  10.1016/j.lungcan.2018.12.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09620, KAKENHI-PROJECT-18K07271
[Journal Article] Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor‐tyrosine kinase inhibitors in patients with EGFR ‐mutant non‐small cell lung cancer2019
- Author(s)
  Matsumoto Yoshiya、Sawa Kenji、Fukui Mitsuru、Oyanagi Jun、Izumi Motohiro、Ogawa Koichi、Suzumura Tomohiro、Watanabe Tetsuya、Kaneda Hiroyasu、Mitsuoka Shigeki、Asai Kazuhisa、Kimura Tatsuo、Yamamoto Nobuyuki、Koh Yasuhiro、Kawaguchi Tomoya
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 3244-3254
- DOI
  10.1111/cas.14156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07176
[Journal Article] Isoflavone Aglycones Attenuate Cigarette Smoke-Induced Emphysema via Suppression of Neutrophilic Inflammation in a COPD Murine Model2019
- Author(s)
  Kojima K, Asai K, Kubo H, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.
- Journal Title
  
  Nutrients
  
  Volume: 11 Pages: 2023-2023
- DOI
  10.3390/nu11092023
- NAID
  120006716419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08660, KAKENHI-PROJECT-17K07176
[Journal Article] <p>Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis</p>2019
- Author(s)
  Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.
- Journal Title
  
  International Journal of Chronic Obstructive Pulmonary Disease
  
  Volume: 14 Pages: 2507-2516
- DOI
  10.2147/copd.s226623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08660, KAKENHI-PROJECT-17K07176
[Journal Article] Genetic Profiling of Non-Small Cell Lung Cancer at Development of Resistance to First- or Second-Generation EGFR-TKIs by CAPP-Seq Analysis of Circulating Tumor DNA.2019
- Author(s)
  Otsubo Kohei、Sakai Kazuko、Takeshita Masafumi、Harada Daijiro、Azuma Koichi、Ota Keiichi、Akamatsu Hiroaki、Goto Koichi、Horiike Atsushi、Kurata Takayasu、Nakagaki Noriaki、Nosaki Kaname、Iwama Eiji、Nakanishi Yoichi、Nishio Kazuto、Okamoto Isamu
- Journal Title
  
  Oncologist
  
  Volume: 24 Pages: 1022-1026
- DOI
  10.1634/theoncologist.2019-0101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271, KAKENHI-PROJECT-18K15214
[Journal Article] Immune‐Related Adverse Events by Immune Checkpoint Inhibitors Significantly Predict Durable Efficacy Even in Responders with Advanced Non‐Small Cell Lung Cancer2019
- Author(s)
  Akamatsu Hiroaki、Murakami Eriko、Oyanagi Jun、Shibaki Ryota、Kaki Takahiro、Takase Eri、Tanaka Masanori、Harutani Yuhei、Yamagata Nao、Okuda Yuka、Furuta Katsuyuki、Sugimoto Takeya、Teraoka Shunsuke、Hayata Atsushi、Tokudome Nahomi、Ozawa Yuichi、Mori Keita、Koh Yasuhiro、Yamamoto Nobuyuki
- Journal Title
  
  The Oncologist
  
  Volume: 25
- DOI
  10.1634/theoncologist.2019-0299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Clinical significance of monitoring EGFR mutation in plasma using multiplexed digital PCR in EGFR mutated patients treated with afatinib (West Japan Oncology Group 8114LTR study)2019
- Author(s)
  Akamatsu H, Yasuhiro Koh, Isamu Okamoto, Daichi Fujimoto, Akihiro Bessho, Koichi Azuma, Satoshi Morita, Nobuyuki Yamamoto, Kazuhiko Nakagawa
- Journal Title
  
  Lung Cancer
  
  Volume: 131 Pages: 128-133
- DOI
  10.1016/j.lungcan.2019.03.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] A Phase II Study of Nivolumab in Patients With Advanced Non?small-cell Lung Cancer who Responded to Prior PD-1/L1 Inhibitors: West Japan Oncology Group 9616L (WJOG9616L)2019
- Author(s)
  Akamatsu Hiroaki、Teraoka Shunsuke、Koh Yasuhiro、Yamanaka Takeharu、Yamamoto Nobuyuki、Nakagawa Kazuhiko
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 20 Pages: 139-141
- DOI
  10.1016/j.cllc.2018.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Heterogeneous Expression of Programmed Death Receptor-ligand 1 on Circulating Tumor Cells in Patients With Lung Cancer2019
- Author(s)
  Koh Yasuhiro、Yagi Satomi、Akamatsu Hiroaki、Kanai Kuninobu、Hayata Atsushi、Tokudome Nahomi、Akamatsu Keiichiro、Higuchi Masayuki、Kanbara Hisashige、Nakanishi Masanori、Ueda Hiroki、Yamamoto Nobuyuki
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 20
- DOI
  10.1016/j.cllc.2019.03.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity2019
- Author(s)
  Kyomoto Yohkoh、Asai Kazuhisa、Yamada Kazuhiro、Okamoto Atsuko、Watanabe Tetsuya、Hirata Kazuto、Kawaguchi Tomoya
- Journal Title
  
  Respiratory Investigation
  
  Volume: 57 Pages: 499-505
- DOI
  10.1016/j.resinv.2019.03.014
- NAID
  120006890446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07176
[Journal Article] Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice2019
- Author(s)
  Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.
- Journal Title
  
  Marine Drugs
  
  Volume: 17 Pages: 673-673
- DOI
  10.3390/md17120673
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08660, KAKENHI-PROJECT-17K07176
[Journal Article] Predictive value of serum protein levels in patients with advanced non-small cell lung cancer treated with nivolumab2019
- Author(s)
  Oyanagi Jun、Koh Yasuhiro、Sato Koichi、Mori Keita、Teraoka Shunsuke、Akamatsu Hiroaki、Kanai Kuninobu、Hayata Atsushi、Tokudome Nahomi、Akamatsu Keiichiro、Nakanishi Masanori、Ueda Hiroki、Yamamoto Nobuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 132 Pages: 107-113
- DOI
  10.1016/j.lungcan.2019.03.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07271
[Journal Article] Osimertinib With Ramucirumab in EGFR-mutated, T790M-positive Patients With Progression During EGFR-TKI Therapy: Phase Ib Study.2018
- Author(s)
  Akamatsu H, Koh Y, Ozawa Y, Fujimoto D, Hata A, Katakami N, Tomii K, Shimokawa T, Yamamoto N.
- Journal Title
  
  Clin Lung Cancer
  
  Volume: 19
- DOI
  10.1016/j.cllc.2018.08.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00044, KAKENHI-PROJECT-18K07271
[Journal Article] PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: a comprehensive mutational analysis from a multi-institutional cohort.2017
- Author(s)
  Sawa Kenji、Koh Yasuhiro、Kawaguchi Tomoya、Kambayashi Satoshi、Asai Kazuhisa、Mitsuoka Shigeki、Kimura Tatsuo、Yoshimura Naruo、Yoshimoto Naoki、Kubo Akihito、Saka Hideo、Matsumura Akihide、Wanibuchi Hideki、Yamamoto Nobuyuki、Nishiyama Noritoshi、Hirata Kazuto
- Journal Title
  
  Lung Cancer
  
  Volume: 112 Pages: 96-101
- DOI
  10.1016/j.lungcan.2017.07.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07128, KAKENHI-PROJECT-17K07176, KAKENHI-PROJECT-17K09162, KAKENHI-PROJECT-15K06878, KAKENHI-PROJECT-15K09185, KAKENHI-PROJECT-15K09226
[Journal Article] Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR2017
- Author(s)
  Watanabe Masaru、Kawaguchi Tomoya、Isa Shun-ichi、Ando Masahiko、Tamiya Akihiro、Kubo Akihito、Saka Hideo、Takeo Sadanori、Adachi Hirofumi、Tagawa Tsutomu、Kawashima Osamu、Yamashita Motohiro、Kataoka Kazuhiko、Ichinose Yukito、Takeuchi Yukiyasu、Watanabe Katsuya、Matsumura Akihide、Koh Yasuhiro
- Journal Title
  
  EBio Medicine
  
  Volume: 21 Pages: 86-93
- DOI
  10.1016/j.ebiom.2017.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07128, KAKENHI-PROJECT-17K07176, KAKENHI-PROJECT-15K06878
[Journal Article] Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study.2016
- Author(s)
  2.Tomoya Kawaguchi, Yasuhiro Koh, Masahiko Ando, Norimasa Ito, Sadanori Takeo, Hirofumi Adachi, Tsutomu Tagawa, Seiichi Kakegawa, Motohiro Yamashita, Kazuhiko Kataoka, Yukito Ichinose, Yukiyasu Takeuchi, Masakuni Serizawa, Akihiro Tamiya, Shigeki Shimizu, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka
- Journal Title
  
  J Clin Oncol.
  
  Volume: 34 Pages: 2247-2257
- DOI
  10.1200/jco.2015.64.2322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460896, KAKENHI-PROJECT-16K07128, KAKENHI-PROJECT-15K06893
[Journal Article] 1.Ultra-sensitive detection of the pretreatment EGFR T790M mutation in non-small-cell lung cancer patients with an EGFR-activating mutation using droplet digital PCR2015
- Author(s)
  Watanabe M, Kawaguchi T, Isa S-I, Ando M, Tamiya A, Kubo A, Saka H, Takeo S, Adachi H, Tagawa T, Kakegawa S, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Sakamoto K, Matsumura A, Koh Y.
- Journal Title
  
  Clin Cancer Res
  
  Volume: in press Pages: 3552-3560
- DOI
  10.1158/1078-0432.ccr-14-2151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-25460896
[Journal Article] Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline.2014
- Author(s)
  Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Kou Y, Nakanishi M, Minakata Y, Yamamoto N.
- Journal Title
  
  Respir Med
  
  Volume: 108 Pages: 976-982
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870509
[Journal Article] Multiplexed molecular profiling of lung cancer using pleural effusion2014
- Author(s)
  Akamatsu H, Koh Y, Kenmotsu H, Naito T, Serizawa M, Kimura M, Mori K, Imai H, Ono A, Shukuya T, Taira T, Murakami H, Ohde Y, Endo M, Nakajima T, Takahashi T, Yamamoto N
- Journal Title
  
  J Thorac Oncol
  
  Volume: 9 Pages: 1048-1052
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870509
[Journal Article] Identification of actionable mutations in malignant pleural mesothelioma.2014
- Author(s)
  Shukuya T, Serizawa M, Watanabe M, Akamatsu H, Abe M, Imai H, Tokito T, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Ohde Y, Nakajima T, Yamamoto N, Koh Y.
- Journal Title
  
  Lung Cancer
  
  Volume: 86 Pages: 35-40
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870509
[Journal Article] Assessment of mutational profile of Japanese lung adenocarcinoma patients by multitarget assays: a prospective, single-institute study.2014
- Author(s)
  Serizawa M, Koh Y, Kenmotsu H, Isaka M, Murakami H, Akamatsu H, Mori K, Abe M, Hayashi I, Taira T, Maniwa T, Takahashi T, Endo M, Nakajima T, Ohde Y, Yamamoto N.
- Journal Title
  
  Cancer
  
  Volume: 15 Pages: 1471-81
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26870509
[Journal Article] A. Rationale and design of Japan Molecular Epidemiology for lung cancer (JME) study2013
- Author(s)
  Kawaguchi T, Ando M, Ito N, Isa SI, Tamiya A, Shimizu S, Saka H, Kubo A, Koh Y, Matsumura A
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 14 Pages: 596-600
- DOI
  10.1016/j.cllc.2013.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501314, KAKENHI-PROJECT-24501363, KAKENHI-PROJECT-25460896
[Patent] METHOD FOR PREDICTING THE DURABLE EFFICACY OF EGFR TYROSINE KINASES INHIBITORS IN EGFR-MUTATED NON-SMALL LUNG CANCER2017
- Inventor(s)
  山本信之、洪泰浩、赤松弘朗
- Industrial Property Rights Holder
  山本信之、洪泰浩、赤松弘朗
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15K09226
[Presentation] EGFR遺伝子変異陽性肺腺癌に対するオシメルチニブ＋ラムシルマブの第I相試験（医師主導治験）2019
- Author(s)
  小澤雄一、赤松弘朗、洪泰浩、山本信之
- Organizer
  肺癌学会2019
- Data Source
  KAKENHI-PROJECT-18K07271
[Presentation] Association between low-frequency pretreatment EGFR T790M mutation and tumor immune microenvironment in patients with EGFR-mutated non-small cell lung cancer.2019
- Author(s)
  Yoshiya Matsumoto, Tomoya Kawaguchi, Yasuhiro Koh, Motohiro Izumi
- Organizer
  American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07176
[Presentation] Impact of somatic mutations on recurrence free survival (RFS) and overall survival (OS) for resected non-small cell lung cancer (NSCLC): results from the Japan Molecular Epidemiology for lung cancer study (JME).2018
- Author(s)
  Tamiya A, Koh Y, Kubo A, Ando M, Isa SI, Saka H, Yoshimoto N, Serizawa M, Takeo S, Adachi H, Tagawa T, Kawashima O, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Watanabe K, Matsumura A, Kawaguchi T.
- Organizer
  Annual Meeting of the American Society of Clinical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07128
[Presentation] Impact of de novo T790M on outcome for resected NSCLC from EGFR mutant cohort of Japan Molecular Epidemiology (JME) study2018
- Author(s)
  Matsumoto Y, Kawaguchi T, Sawa K, Watanabe M, Isa S-I, Ando M, Tamiya A, Kubo A, Saka H, Matsumura A, Koh Y
- Organizer
  19th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07128
[Presentation] Predictive values of serum protein levels in advanced non-small-cell lung cancer patients treated with nivolumab.2018
- Author(s)
  Oyanagi J, Koh Y, Akamatsu H, Kanai K, Hayata A, Tokudome N, Akamatsu K, Nakanishi M, Ueda H, Yamamoto N:
- Organizer
  American Association for Cancer Research Annual Meeting
- Data Source
  KAKENHI-PROJECT-18K07271
[Presentation] Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors2018
- Author(s)
  Yoshiya Matsumoto, Kenji Sawa, Jun Oyanagi, Mitsuru Fukui, Naoki Yoshimoto, Tomohiro Suzumura, Shigeki Mitsuoka, Kazuhisa Asai, Tatsuo Kimura, Nobuyuki Yamamoto, Tomoya Kawaguchi, Kazuto Hirata, and Yasuhiro Koh
- Organizer
  American Association of Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07176
[Presentation] Predictive impact of sequential evaluation of PD-L1-expressing circulating tumor cells in NSCLC patients treated with nivolumab.2018
- Author(s)
  Koh Y, Akamatsu H, Mori K, Kanai K, Hayata A, Tokudome N, Higuchi M, Akamatsu K, Nakanishi M, Ueda H, Yamamoto N
- Organizer
  American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07271
[Presentation] Impact of de Novo T790M on Outcome for Resected NSCLC from EGFR Mutant Cohort of Japan Molecular Epidemiology (JME) Study2018
- Author(s)
  Y. Matsumoto, T. Kawaguchi, K. Sawa, S. Isa, M. Ando, A. Tamiya, A. Kubo, H. Saka, A. Matsumura, Y. Koh
- Organizer
  World Congress of Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07176
[Presentation] Impact of somatic mutations on recurrence free survival (RFS) and overall survival (OS) for resected non-small cell lung cancer (NSCLC): results from the Japan Molecular Epidemiology for lung cancer study (JME)2018
- Author(s)
  Tamiya A, Koh Y, Kubo A, Ando M, Isa SI, Saka H, Yoshimoto N, Serizawa M, Takeo S, Adachi H, Tagawa T, Kawashima O, Yamashita M, Kataoka K, Ichinose Y, Takeuchi Y, Watanabe K, Matsumura A, Kawaguchi T
- Organizer
  Annual Meeting of the American Society of Clinical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07128
[Presentation] Impact of somatic mutations on recurrence free survival (RFS) and overall survival (OS) for resected non-small cell lung cancer (NSCLC): results from the Japan Molecular Epidemiology for lung cancer study (JME)2018
- Author(s)
  Akihiro Tamiya, Yasuhiro Koh, Akihito Kubo, Masahiko Ando, Shun-ichi Isa, Hideo Saka, Naoki Yoshimoto, Masakuni Serizawa, Sadanori Takeo, Hirofumi Adachi, Tsutomu Tagawa,
- Organizer
  American Societry of Clinical Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07176
[Presentation] Non-invasive identification of tumor cells using near infrared composition imaging system.2017
- Author(s)
  Koh Y
- Organizer
  AACR2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Non-invasive identification of tumor cells using near infrared composition imaging system2017
- Author(s)
  Koh Y
- Organizer
  AACR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09226
[Presentation] Comparison of PD-L1 expression between tumor tissues and circulating tumor cells and tumor tissues in patients with lung cancer2016
- Author(s)
  Koh Y
- Organizer
  EORTC-NCI-AACR
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09226
[Presentation] Comparative analysis of PD-L1 expression between circulating tumor cells and tumor tissues in patients with lung cancer2016
- Author(s)
  Koh Y
- Organizer
  IASLC 17th World Conference on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Comparison of PD-L1 expression between tumor tissues and circulating tumor cells and tumor tissues in patients with lung cancer2016
- Author(s)
  Koh Y
- Organizer
  EORTC-NCI-AACR 2016
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Ultra-sensitive picodroplet digital PCR assay for multiplex genotyping of mutations in epidermal growth factor receptor (EGFR) in non-small cell lung cancer patients2016
- Author(s)
  Koh Y
- Organizer
  American Association for Cancer Research Annual Meeting 2016
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Comparative analysis of PD-L1 expression between circulating tumor cells and tumor tissues in patients with lung cancer2016
- Author(s)
  Koh Y,
- Organizer
  IASLC 17th World Conference on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09226
[Presentation] Establishment of multiplexed ultra-sensitive detection of epidermal growth factor receptor mutations using picodroplet digital PCR2015
- Author(s)
  Hiroaki Akamatsu, Yasuhiro Koh, Masaru Watanabe, Takashi Kikuchi, Masanori Nakanishi, Kazuto Matsunaga, Nobuyuki Yamamoto.
- Organizer
  American Association of Cancer Research Annual Meeting 2015
- Place of Presentation
  Pennsylvania Convention Center
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] NGS:次世代シーケンサーを用いたこれからの肺がん診療に向けて2015
- Author(s)
  洪　泰浩
- Organizer
  第56回日本肺癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2015-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Liquid biopsies: noninvasive longitudinal monitoring of lung cancer2015
- Author(s)
  Yasuhiro Koh
- Organizer
  The 2015 Oriental Congress of Laboratory Medicine
- Place of Presentation
  Shanghai, China
- Year and Date
  2015-12-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Establishment of novel multiplexed assay to detect EGFR mutations using ultra-sensitive digital PCR2015
- Author(s)
  赤松弘朗、洪泰浩、山本信之ら
- Organizer
  ESMO Asia 2015
- Place of Presentation
  Suntec, Singapore
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] Liquid biopsies: noninvasive longitudinal monitoring of lung cancer.2015
- Author(s)
  洪泰浩
- Organizer
  第 13 回日本臨床腫瘍学会学術集会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] Ultrasensitive detection of the pretreatment EGFR T790M mutation in non-small cell lung cancer patients with an EGFR-activating mutation using picodroplet digital PCR2015
- Author(s)
  Yasuhiro Koh
- Organizer
  American Association for Cancer Research Annual Meeting 2015
- Place of Presentation
  Philadelphia, Pennsylvania, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Establishment of multiplexed ultra-sensitive detection of epidermal growth factor receptor mutations using picodroplet digital PCR.2015
- Author(s)
  赤松弘朗、洪泰浩、山本信之ら
- Organizer
  American Association for Cancer Research Annual Meeting 2015
- Place of Presentation
  Pennsylvania convention center, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] 胸部原発悪性腫瘍における個別化医療の現状と今後の展望について2015
- Author(s)
  洪泰浩
- Organizer
  第 74 回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] 胸部原発悪性腫瘍における個別化医療の現状と今後の展望について2015
- Author(s)
  洪　泰浩
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K06878
[Presentation] Liquid biopsies: noninvasive longitudinal monitoring of lung cancer2015
- Author(s)
  Yasuhiro Koh
- Organizer
  The 2015 Oriental Congress of Laboratory Medicine
- Place of Presentation
  Shanghai, China
- Year and Date
  2015-12-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09226
[Presentation] Droplet Digital PCR を用いた EGFR 遺伝子変異のマルチプレックス検出2014
- Author(s)
  渡辺勝、洪泰浩、赤松弘朗、菊池崇史、松永和人、山本信之
- Organizer
  日本肺癌学会総会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-26870509
[Presentation] In vitro tyrosine kinase activity profiling to identify molecular targets and predictive biomarkers in gastric cancer cell lines2013
- Author(s)
  Yasuhiro Koh
- Organizer
  AACR annual meeting 2013
- Place of Presentation
  ワシントンDC（米国）
- Data Source
  KAKENHI-PROJECT-24501363
[Presentation] Identification of actionable mutations in surgically resected tumor specimens from Japanese patients with non-small cell lung cancer by ultra-deep targeted sequencing2013
- Author(s)
  Yasuhiro Koh
- Organizer
  American Society of Clinical Oncology annual meeting
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-24501363
[Presentation] Identification of actionable mutations in surgically resected tumor specimens from Japanese patients with non-small cell lung cancer by ultra-deep targeted sequencing2013
- Author(s)
  Yasuhiro Koh
- Organizer
  49th American Society of Clinical Oncology
- Place of Presentation
  米国シカゴ
- Invited
- Data Source
  KAKENHI-PROJECT-24591186
[Presentation] Prospective mutational characterization of Japanese patients with non-small-cell lung cancer using surgically resected tumor specimens by next-generation sequencing2013
- Author(s)
  Yasuhiro Koh
- Organizer
  Markers in Cancer
- Place of Presentation
  Brussels
- Data Source
  KAKENHI-PROJECT-24501363
[Presentation] In vitro tyrosine kinase activity profiling to identify molecular targets and predictive biomarkers in gastric cancer cell lines2013
- Author(s)
  Yasuhiro Koh
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-24501363
[Presentation] Development of novel systems for the detection of circulating tumor cells in Japan2012
- Author(s)
  洪　泰浩
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24501363
[Presentation] 非小細胞肺癌(NSCLC)の癌性胸膜炎(MPE)におけるゲフィチニブの薬力学・薬物動態・臨床第II相試験2011
- Author(s)
  久保昭仁、洪　泰浩、堀　隆、伊佐俊一、福岡順也、川口知哉、安藤昌彦、岡本　勇、北市正則、安宅信二、河原正明、楠　洋子、山口悦郎、中川和彦、高田　實
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501314

1. YAMAMOTO Nobuyuki (60298966)

# of Collaborated Projects: 7 results

# of Collaborated Products: 23 results
2. Akamatsu Hiroaki (10646582)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
3. KIKUCHI Takashi (40649050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. KUBO Akihito (60416245)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. KAWAGUCHI Tomoya (70254422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. NAKAJIMA Takashi (20124422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KONDO Haruhiko (60399590)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ENDO Masahiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. FUKUOKA Junya (00324575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TAKADA Minoru (20373516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. ISA Shun-Ichi (60421913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. BOKU Narikazu (50505948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SERIZAWA Masakuni (00569915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 小澤雄一 (50838498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小柳潤 (80716069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YASUI Hirofumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ASAI Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. SHIMOKAWA Toshio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 堀田信之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 鰐渕英機

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 安藤昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
22. 岩間映二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOU Yasuhiro 洪 泰浩

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KRAS変異陽性肺がんにおける次世代個別化医療の実現へ向けた基盤研究Principal Investigator

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Development of VHL-targeted therapy in malignant pleural mesotheliomaPrincipal Investigator

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Cancer therapeutic target identification by comprehensive kinase profilingPrincipal Investigator

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[Book] リキッドバイオプシー―体液中腫瘍マーカーの検出・解析技術―2017

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[Book] デジタルPCRの原理と臨床腫瘍学での有用性2016

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[Book] 新臨床腫瘍学2015

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KOU Yasuhiro 洪泰浩

[Book] がん分子標的治療　腫瘍の遺伝子情報の臨床への応用2014