ONO KISHO 小野喜章

Researcher Number	30845384
Other IDs	https://orcid.org/0000-0002-0199-9907
Affiliation (based on the past Project Information) *help	2019 – 2023: 岡山大学, 大学病院, 医員 2020: 岡山大学, 岡山大学病院口腔外科, 医員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator バイオマーカー / 細胞外小胞 / エクソソーム / シスプラチン / ATP7B / 銅輸送経路 / 治療抵抗性 / 薬剤耐性 / 口腔癌 / 新規体液診断 … More / 腫瘍進展・転移 / HSP90 / 分子シャペロン / 口腔扁平上皮癌 … More Except Principal Investigator 癌性骨疼痛 / 癌関連線維芽細胞 / 癌の骨転移 / Lysyl oxidase / 骨破壊 / 骨転移 / 癌の骨浸潤 / 癌性骨痛 / 破骨細胞 / 高カルシウム血症 / 口腔癌 / 銅キレート Less

Cisplatin-resistance via cancer extracellular vesicles in oral squamous cell carcinoma.Principal Investigator
- Principal Investigator
  
  ONO KISHO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Okayama University
Establishment of therapeutic strategies using copper chelates for bone destruction lesions of cancer and analysis of their functional mechanisms
- Principal Investigator
  
  Sasaki Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Okayama University
Establishment of new diagnostic method and system of therapeutics by comprehensive analysis of oral cancer exosomes.Principal Investigator
- Principal Investigator
  
  ONO KISHO
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Novel mechanism of cisplatin resistance in head and neck squamous cell carcinoma involving extracellular vesicles and a copper transporter system2024
- Author(s)
  Ogawa Tatsuo、Ono Kisho、Ryumon Shoji、Kawai Hotaka、Nakamura Tomoya、Umemori Koki、Yoshida Kunihiro、Kanemoto Hideka、Obata Kyoichi、Yoshioka Norie、Okui Tatsuo、Okamoto Kuniaki、Nagatsuka Hitoshi、Ibaragi Soichiro
- Journal Title
  
  Head & Neck
  
  Volume: 46 Issue: 3 Pages: 636-650
- DOI
  10.1002/hed.27620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17137, KAKENHI-PROJECT-21K17115
[Journal Article] Multiple Targeting of HSP Isoforms to Challenge Isoform Specificity and Compensatory Expression2023
- Author(s)
  Ono Kisho、Eguchi Takanori
- Journal Title
  
  Chaperones, Springer Nature Switzerland AG
  
  Volume: 2693 Pages: 141-161
- DOI
  10.1007/978-1-0716-3342-7_12
- ISBN
  9781071633410, 9781071633427
- Data Source
  KAKENHI-PROJECT-21K17115
[Journal Article] Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-Free Fractions, and Cells2023
- Author(s)
  Ono Kisho、Okusha Yuka、Tran Manh Tien、Umemori Koki、Eguchi Takanori
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2582 Pages: 39-57
- DOI
  10.1007/978-1-0716-2744-0_5
- ISBN
  9781071627433, 9781071627440
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-21K17115, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-23K19508
[Journal Article] Proteomic Profiling of the Extracellular Vesicle Chaperone in Cancer2023
- Author(s)
  Ono Kisho、Eguchi Takanori
- Journal Title
  
  Chaperones, Springer Nature Switzerland AG
  
  Volume: 2693 Pages: 233-249
- DOI
  10.1007/978-1-0716-3342-7_18
- ISBN
  9781071633410, 9781071633427
- Data Source
  KAKENHI-PROJECT-21K17115
[Journal Article] Multiplex Immunostaining Method to Distinguish HSP Isoforms in Cancer Tissue Specimens2023
- Author(s)
  Kawai Hotaka、Ono Kisho、Eguchi Takanori
- Journal Title
  
  Inteck Open
  
  Volume: 1 Pages: 281-291
- DOI
  10.1007/978-1-0716-3342-7_21
- ISBN
  9781071633410, 9781071633427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17089, KAKENHI-PROJECT-21K17115
[Journal Article] EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma2023
- Author(s)
  Umemori Koki、Ono Kisho、Eguchi Takanori、Kawai Hotaka、Nakamura Tomoya、Ogawa Tatsuo、Yoshida Kunihiro、Kanemoto Hideka、Sato Kohei、Obata Kyoichi、Ryumon Shoji、Yutori Hirokazu、Katase Naoki、Okui Tatsuo、Nagatsuka Hitoshi、Ibaragi Soichiro
- Journal Title
  
  Oral Oncology
  
  Volume: 142 Pages: 106433-106433
- DOI
  10.1016/j.oraloncology.2023.106433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17089, KAKENHI-PROJECT-22KK0275, KAKENHI-PROJECT-21K17115, KAKENHI-PROJECT-23K20333
[Journal Article] Large-Scale Databases and Portals on Cancer Genome to Analyze Chaperone Genes Correlated to Patient Prognosis2023
- Author(s)
  Ono Kisho、Eguchi Takanori
- Journal Title
  
  Chaperones, Springer Nature Switzerland AG
  
  Volume: 2693 Pages: 293-306
- DOI
  10.1007/978-1-0716-3342-7_22
- ISBN
  9781071633410, 9781071633427
- Data Source
  KAKENHI-PROJECT-21K17115
[Journal Article] Comprehensive Method for Exosome Isolation and Proteome Analysis for Detection of CCN Factors in/on Exosomes2022
- Author(s)
  Eguchi Takanori、Okusha Yuka、Lu Yanyin、Ono Kisho、Taha Eman A.、Fukuoka Shiro
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2582 Pages: 59-76
- DOI
  10.1007/978-1-0716-2744-0_6
- ISBN
  9781071627433, 9781071627440
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17115, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-23K19508
[Journal Article] Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer2022
- Author(s)
  Ono Kisho、Sato Kohei、Nakamura Tomoya、Yoshida Yume、Murata Shogo、Yoshida Kunihiro、Kanemoto Hideka、Umemori Koki、Kawai Hotaka、Obata Kyoichi、Ryumon Shoji、Hasegawa Kazuaki、Kunisada Yuki、Okui Tatsuo、Ibaragi Soichiro、Nagatsuka Hitoshi、Sasaki Akira
- Journal Title
  
  International Journal of Medical Sciences
  
  Volume: 19 Issue: 8 Pages: 1320-1333
- DOI
  10.7150/ijms.74109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17115, KAKENHI-PROJECT-23K20333
[Journal Article] A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs.2020
- Author(s)
  Eguchi T, Taha EA, Calderwood SK, Ono K.
- Journal Title
  
  Biology (Basel).
  
  Volume: 9(3). Issue: 3 Pages: 47-47
- DOI
  10.3390/biology9030047
- NAID
  120006881477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-19K24072
[Journal Article] High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer2020
- Author(s)
  Nakamura Tomoya、Okui Tatsuo、Hasegawa Kazuaki、Ryumon Shoji、Ibaragi Soichiro、Ono Kisho、Kunisada Yuki、Obata Kyoichi、Masui Masanori、Shimo Tsuyoshi、Sasaki Akira
- Journal Title
  
  Oncology Reports
  
  Volume: 44 Issue: 6 Pages: 2547-2558
- DOI
  10.3892/or.2020.7788
- NAID
  120007004824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03889
[Journal Article] High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR42020
- Author(s)
  Sakamoto Yumi、Okui Tatsuo、Yoneda Toshiyuki、Ryumon Shoji、Nakamura Tomoya、Kawai Hotaka、Kunisada Yuki、Ibaragi Soichiro、Masui Masanori、Ono Kisho、Obata Kyoichi、Shimo Tsuyoshi、Sasaki Akira
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 3 Pages: 422-430
- DOI
  10.1016/j.bbrc.2020.07.120
- NAID
  120006890006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03859, KAKENHI-PROJECT-20H03889
[Journal Article] Triple knockdown of CDC37, HSP90-alpha, and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.2020
- Author(s)
  Ono K, Sogawa C, Kawai H, Tran MT, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki K, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T
- Journal Title
  
  J Extracell Vesicles
  
  Volume: in press Issue: 1 Pages: 1769373-1769373
- DOI
  10.1080/20013078.2020.1769373
- NAID
  120006956812
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-20K09904, KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K24072
[Presentation] 頭頸部癌におけるセツキシマブ感受性予測バイオマーカーとしてのEpCAMの可能性2023
- Author(s)
  小野喜章, 梅森洸樹, 中村友哉, 小川辰雄, 金本栄華, 吉田国弘, 小畑協一, 竜門省二, 柚鳥宏和, 河合穂高, 片瀬直樹, 奥井達雄, 長塚仁, 伊原木聰一郎
- Organizer
  第41回日本口腔腫瘍学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 口腔癌の細胞外小胞と銅輸送経路に着目したシスプラチン耐性機構の解明と克服のための挑戦的研究2023
- Author(s)
  小野喜章, 竜門省二, 小畑協一, 河合穂高, 奥井達雄, 伊原木聰一郎
- Organizer
  第77回NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] シスプラチン耐性機構の解明に向けた口腔癌の細胞外小胞と銅輸送経路の検討2022
- Author(s)
  小野喜章, 小川辰雄, 竜門省二, 吉田国弘, 金本栄華, 梅森洸樹, 坂本裕美, 増井正典, 小畑協一, 奥井達雄, 伊原木聰一郎
- Organizer
  第58回日本口腔組織培養学会学術大会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 頭頸部扁平上皮癌における EpCAM誘導性セツキシマブ耐性獲得機構の解明2022
- Author(s)
  小野喜章, 小畑協一, 増井正典, 吉岡德枝, 伊原木聰一郎, 佐々木朗
- Organizer
  第46回日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 口腔扁平上皮癌におけるEpCAM誘導性セツキシマブ耐性獲得機構の解明2022
- Author(s)
  梅森洸樹, 小野喜章, 金本栄華, 小畑協一, 吉岡德枝, 伊原木聰一郎
- Organizer
  第32回日本口腔内科学会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] EGFR 活性化経路としての EpCAM に着目した口腔扁平上皮癌のセツキシマブ耐性機構の解明2022
- Author(s)
  梅森洸樹, 小野喜章, 小畑協一, 竜門省二, 中村友哉, 金本栄華, 吉田国弘, 河合穂高, 伊原木聰一郎
- Organizer
  第58回日本口腔組織培養学会学術大会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 口腔癌のシスプラチン耐性獲得における細胞外小胞と銅輸送経路の検証2022
- Author(s)
  小川辰雄, 小野喜章, 竜門省二, 吉田国弘, 奥井達雄, 伊原木聰一朗, 佐々木朗
- Organizer
  第67回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 細胞外小胞と銅輸送経路に着目した口腔癌のシスプラチン耐性機構の解明2022
- Author(s)
  小野喜章, 竜門省二, 金本栄華, 梅森洸樹, 坂本裕美, 小畑協一, 吉岡徳枝, 伊原木聰一郎, 佐々木朗
- Organizer
  第32回日本口腔内科学会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 口腔癌の薬剤応答性に対する3次元培養モデル有用性の検証2021
- Author(s)
  佐藤晃平, 小野喜章, 吉田夢, 中村友哉, 梅森洸樹, 金本栄華, 吉田国弘, 小畑協一, 伊原木聰一郎, 佐々木朗
- Organizer
  第57回口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 口腔癌のエクソソームを介した腫瘍進展機序の解明と新規治療戦略の開発に向けて -分子シャペロン搭載エクソソームの可能性-2021
- Author(s)
  小野喜章, 江口傑徳, 十川千春, 奥舎有加, 岡元邦彰, 佐々木朗
- Organizer
  第57回口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-21K17115
[Presentation] 3 次元培養システムを用いた口腔癌の薬剤応答性に対する新規in vitroモデルの検証2021
- Author(s)
  佐藤晃平, 小野喜章, 河合穂高, 中野敬介, 長塚仁, 佐々木朗
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21K17115

1. Sasaki Akira (00170663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 志茂剛 (40362991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 奥井達雄 (40610928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 吉岡徳枝 (50362984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 伊原木聰一郎 (80549866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 増井正典 (80881143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. EGUCHI Takanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 國定勇希

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 河合穂高

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 岡元邦彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 青木千春

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 奥舎有加

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ONO KISHO 小野 喜章

Research Projects

Research Products

Co-Researchers

Cisplatin-resistance via cancer extracellular vesicles in oral squamous cell carcinoma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of therapeutic strategies using copper chelates for bone destruction lesions of cancer and analysis of their functional mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of new diagnostic method and system of therapeutics by comprehensive analysis of oral cancer exosomes.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Novel mechanism of cisplatin resistance in head and neck squamous cell carcinoma involving extracellular vesicles and a copper transporter system2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multiple Targeting of HSP Isoforms to Challenge Isoform Specificity and Compensatory Expression2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-Free Fractions, and Cells2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Proteomic Profiling of the Extracellular Vesicle Chaperone in Cancer2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Multiplex Immunostaining Method to Distinguish HSP Isoforms in Cancer Tissue Specimens2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Large-Scale Databases and Portals on Cancer Genome to Analyze Chaperone Genes Correlated to Patient Prognosis2023

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Comprehensive Method for Exosome Isolation and Proteome Analysis for Detection of CCN Factors in/on Exosomes2022

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs.2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer2020

ONO KISHO 小野喜章