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SHIMO Tsuyoshi  志茂 剛

Researcher Number 40362991
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-7811-2366
Affiliation (Current) 2022: 北海道医療大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2022: 北海道医療大学, 歯学部, 教授
2017: 岡山大学, 大学院医歯薬学総合研究科, 准教授
2013 – 2016: 岡山大学, 医歯(薬)学総合研究科, 准教授
2013: 岡山大学, 大学院・医歯薬学総合研究科, 准教授
2012: 岡山大学, 医歯(薬)学総合研究科, 助教 … More
2007 – 2011: Okayama University, GRADUATE SCHOOL OF MEDICINE, DENTISTRY, PHARMACEUTICAL SCIENCES, ASSOCIATE PROFESSOR
2005 – 2006: 岡山大学, 大学院・医歯薬学総合研究科, 助手
2005 – 2006: 岡山大学, 大学院医歯薬学総合研究科, 助手
2004: 岡山大学, 大学院・医歯学総合研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Except Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related / Oral Science and related fields / Functional basic dentistry / Basic Section 57040:Regenerative dentistry and dental engineering-related
Keywords
Principal Investigator
破骨細胞 / ヘッジホッグ / 癌骨破壊 / 口腔扁平上皮癌 / 血管新生 / ソニックヘッジホッグ / 癌 / 骨破壊 / 変形性関節症 / レチノイドアンタゴニスト … More / 軟骨基質 / マトリックスメタロプロテアーゼ / レチノイドシグナル / FAK / 癌骨浸潤 / 骨折 / 顎変形症 / 顎骨浸潤 / 癌顎骨破壊 / 破骨細胞分化 / 口腔癌 / 顎骨破壊 / Hedgehog / 癌骨微小環境 … More
Except Principal Investigator
破骨細胞 / 口腔扁平上皮癌 / 骨浸潤 / 口腔癌 / 血管新生因子 / 骨破壊 / 癌関連線維芽細胞 / 血管新生 / angiogenin / 血管新生阻害薬 / 骨微小環境 / 顎骨浸潤 / HIF-1α / 腫瘍間質 / 癌化 / オルガノイド / PRL-3 / ノックダウン / 骨基質 / neomycine / 癌誘発骨破壊 / angionenin / 骨破壊モデル / ノックアウトマウス / 癌 / 骨吸収 / がん関連線維芽細胞 / 骨吸収因子 / 評価モデル / TGF-β / TβRI-I / 顎骨破壊 / 骨吸収マーカー / 術前予測 / 診断マーカー / 骨浸潤評価 / osteoclastic bone resorption / angiogenesis / osteoclasts / bone invasion / bone destruction / oral squamous carcinoma / evaluation model / transforming growth factor-β / CDDP(シスプラチン)耐性 / 固形癌内部環境 / 低酸素環境 / DNA修復機構 / シスプラチン(CDDP)耐性 / NIF-1α / グルコース飢餓環境 / DNAミスマッチ修復 / ヌクレオチド除去修復 / CDDP (Cisnlatin) resistance / solid cancer internal environment / hvnoxia / DNA repair mechanism / CCN2 / CCN3 / 解糖系 / エネルギー代謝 / ワールブルグ効果 / CCN family / Warburg effect / glycolysis / carcinogenesis / マスト細胞 / 癌骨破壊病変 / ケミカルメディエーター / 骨破壊病変 / 骨吸収機構 / ケミカルメディエータ- / CCNファミリー / CCN2/CTGF / 軟骨 / 変形性関節症 / 受容体 / モジュール / LIPUS / 半月板 / Vasohibin 1 / CC3/Nov / シグナル伝達 / CCN3/Nov / 再生 / がん / 扁平上皮癌 / 生物学的性格 / 癌間質 / 相互作用 / 腫瘍微小環境 / 組織型 / 浸潤 / 唾石 / 溶解療法 / 唾液腺内視鏡 / クエン酸 / 次亜塩素酸ナトリウム / 唾石摘出 / 破砕術 / 歯根膜細胞 / Gli1 / Shh / Sonic hedgehog / stem cells / Periodontal ligament / Animal experiment / 銅キレート / Lysyl oxidase / 癌の骨転移 / 癌の骨浸潤 / 癌性骨疼痛 / 高カルシウム血症 / 骨転移 / 高浸潤型 / 低浸潤型 / 細胞競合 / エピゲノム / 癌性疼痛 / 骨代謝 / 骨痛 Less
  • Research Projects

    (23 results)
  • Research Products

    (101 results)
  • Co-Researchers

    (55 People)
  •  癌の骨破壊病変に対するHedgehogシグナルの分子基盤の構築と新たな治療戦略Principal Investigator

    • Principal Investigator
      志茂 剛
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  細胞競合による癌の生物学的性格および癌化の制御

    • Principal Investigator
      中野 敬介
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  口腔癌骨破壊病変における知覚神経と癌細胞の相互作用メカニズムの解明

    • Principal Investigator
      奥井 達雄
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Shimane University
  •  Shh-Gli1応答性歯根膜幹細胞分化機構の解明と歯槽骨再生への応用

    • Principal Investigator
      建部 廣明
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57040:Regenerative dentistry and dental engineering-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  癌の骨破壊病変に対する銅のキレートを応用した治療戦略の構築とその制御機構の解析

    • Principal Investigator
      佐々木 朗
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  Basic study on the development of combination therapy with the lithotripsy and double litholysis using protein and calcic dissolution liquid under sialendoscopy

    • Principal Investigator
      中山 英二
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  PRL-3による口腔扁平上皮癌の顎骨浸潤抑制メカニズムの解明

    • Principal Investigator
      吉田 祥子
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  Regulation of the biological character of cancer and induction of cancer by the cancer stroma.

    • Principal Investigator
      Nakano Keisuke
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signalingPrincipal Investigator

    • Principal Investigator
      SHIMO Tsuyoshi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  New potential of CCN2: Functional evaluation as a Warburg effector

    • Principal Investigator
      Kubota Satoshi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Oral Science and related fields
    • Research Institution
      Okayama University
  •  The relationship between cancer-associted fibroblast and mast cell on the osteolysis of cancer induced bone disease

    • Principal Investigator
      Sasaki Akira
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Function of PRL-3 in oral squamous cell carcinoma

    • Principal Investigator
      Yoshida Shoko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University
  •  Development of new therapies targeting SHH in oral cancer jaw bone destruction and its application to personalized medicinePrincipal Investigator

    • Principal Investigator
      Tsuyoshi Shimo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Role of cancer-associate fibroblasts on the regulation of angiognesis and bone resorption

    • Principal Investigator
      SASAKI AKIRA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Establishment of new jawbone healing evaluation in the old and middle age patient of jaw deformity after surgeryPrincipal Investigator

    • Principal Investigator
      TSUYOSHI Shimo
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Development of molecular target therapy using new angiogenin inhibitor against cancer induced bone diseases

    • Principal Investigator
      SASAKI AKIRA
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  A new therapeutic strategy for tumor induced bone destruction targeting FAKPrincipal Investigator

    • Principal Investigator
      SHIMO Tsuyoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Investigation of mechanism of angiogenesis factor, angiogenin, as a molecular target against cancer-induced bone destruction

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  癌骨浸潤におけるヘッジホッグの破骨細胞性骨吸収とそのメカニズムの解析Principal Investigator

    • Principal Investigator
      志茂 剛
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMOR

    • Principal Investigator
      MESE Hiroshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  The development of evaluation model of the cancer bone invasion reproducing bone microenvironment and the search of the new diagnosis marker for the cancer-induced bone resorption

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  軟骨代謝を標的にした新たな変形性関節症の治療法の開発Principal Investigator

    • Principal Investigator
      志茂 剛
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University

All 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

  • [Book] Hedgehog Signaling in Organogenesis and Tumor Microenvironment2020

    • Author(s)
      Kiyofumi Takabatake, Tsuyoshi Shimo, Jun Murakami, Chang Anqi, Hotaka Kawai, Saori Yoshida, May Wathone Oo, Omori Haruka, Shintaro Sukegawa, Hidetsugu Tsujigiwa, Keisuke Nakano and Hitoshi Nagatsuka
    • Total Pages
      161
    • Publisher
      MDPI
    • ISBN
      9784263731970
    • Data Source
      KAKENHI-PROJECT-18K09789
  • [Book] Analysis of pathological activities of CCN proteins in bone metastasis2016

    • Author(s)
      Tsuyoshi Shimo, Norie Yoshioka, Masaharu Takigawa, and Akira Sasaki
    • Total Pages
      576
    • Publisher
      Springer Publishing Company, New York
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Book] Protocol for measuring angiogenic activities of CCN proteins2016

    • Author(s)
      Tsuyoshi Shimo and Masaharu Takigawa
    • Total Pages
      576
    • Publisher
      Springer Publishing Company, New York
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Book] Oral Squamous Cell Carcinoma2012

    • Author(s)
      Tsuyoshi Shimo
    • Total Pages
      10
    • Publisher
      InTech
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Book] Squamous Cell Carcinoma : Role of connective tissue growth factor(CTGF/CCN2) in oral squamous cell carcinoma-induced bone destruction2012

    • Author(s)
      Tsuyoshi Shimo, Akira Sasaki
    • Publisher
      InTech
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment2021

    • Author(s)
      Shoko Yoshida, Tsuyoshi Shimo, Kiyofumi Takabatake, Yurika Murase, Kyoichi Obata, Tatsuo Okui, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki
    • Journal Title

      Diagnostics (Basel, Switzerland)

      Volume: 11 Pages: 1044-1044

    • NAID

      120007116755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Journal Article] Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment2021

    • Author(s)
      Yoshida Shoko、Shimo Tsuyoshi、Takabatake Kiyofumi、Murase Yurika、Obata Kyoichi、Okui Tatsuo、Kunisada Yuki、Ibaragi Soichiro、Nagatsuka Hitoshi、Sasaki Akira
    • Journal Title

      Diagnostics

      Volume: 11 Pages: 1044-1044

    • DOI

      10.3390/diagnostics11061044

    • NAID

      120007116755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10308, KAKENHI-PROJECT-19K19159
  • [Journal Article] Intraosseous clear cell mucoepidermoid carcinoma in the maxilla: A case report and review of literature.2021

    • Author(s)
      Harada Fumiya, Abiko Yoshihiro, Khurelchuluun Ariuntsetseg, Yoshida Koki, Takeda Shigehiro, Nakayama Eiji, Shimo Tsuyoshi, Nagayasu Hiroki
    • Journal Title

      Clinical Case Reports

      Volume: 9 Pages: 1-7

    • DOI

      10.1002/ccr3.4447

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] A challenging diagnosis of a mucocele in the maxillary gingiva: Case report and literature review.2021

    • Author(s)
      Nagwan Elsayed, Tsuyoshi Shimo, Fumiya Harada, Daichi Hiraki, Masayasu Tashiro, Eiji Nakayama, Yoshihiro Abiko, Hiroki Nagayasu
    • Journal Title

      International Journal of Surgery Case Reports

      Volume: 84 Pages: 1-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Asymptomatic submandibular giant calculus left for 24 years: A case report2020

    • Author(s)
      Karnoon Shamsoon, Fumiya Harada, Shintaro Yodogawa, Shigehiro Takeda, Saki Fujii, Yoshihiro Abiko, Eiji Nakayama, Takashi, Saito, Hiroki Nagayasu, Tsuyoshi Shimo
    • Journal Title

      Surgery and Rehabilitation

      Volume: 4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Masticatory Muscle Tendon-Aponeurosis Hyperplasia That Was Difficult to Diagnose Preoperatively2020

    • Author(s)
      Nagwan Elsayed, Tsuyoshi Shimo, Fumiya Harada, Shigehiro Takeda,Yasuhito Minamida, Daichi Hiraki, Marie Wakabayashi, Kohei Sato, Yoshihiro Abiko, Masayasu Tashiro, Eiji Nakayama,Tomofumi Kawakami,Hiroki Nagayasu
    • Journal Title

      Surgery and Rehabilitation

      Volume: 4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Stem cell properties of Gli1-positive cells in the periodontal ligament.2020

    • Author(s)
      Hosoya A, Shalehin N, Takebe H, Fujii S, Seki Y, Mizoguchi T, Shimo T, Iijima M, Irie K
    • Journal Title

      Journal of oral biosciences

      Volume: 62 Pages: 299-305

    • DOI

      10.1016/j.job.2020.08.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09641, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-20K09995, KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03853
  • [Journal Article] Sonic Hedgehog Signaling and Tooth Development2020

    • Author(s)
      Hosoya Akihiro、Shalehin Nazmus、Takebe Hiroaki、Shimo Tsuyoshi、Irie Kazuharu
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 21 Pages: 1587-1587

    • DOI

      10.3390/ijms21051587

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K17090, KAKENHI-PROJECT-18K09641, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-18H02999
  • [Journal Article] Expression and Role of IL-1β Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing2020

    • Author(s)
      Shimo Tsuyoshi、Takebe Hiroaki、Okui Tatsuo、Kunisada Yuki、Ibaragi Soichiro、Obata Kyoichi、Kurio Naito、Shamsoon Karnoon、Fujii Saki、Hosoya Akihiro、Irie Kazuharu、Sasaki Akira、Iwamoto Masahiro
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 21 Pages: 2365-2365

    • DOI

      10.3390/ijms21072365

    • NAID

      120007127458

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K17090, KAKENHI-PROJECT-18K09641, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-18H02999
  • [Journal Article] Tooth extraction in a patient with juvenile osteoporosis and cardiovascular disease2020

    • Author(s)
      Tsuyoshi Shimo, Fumiya Harada, Kazuhiro Miyamoto, Tatsuji Odachi, Masahiro Ishikawa, Karnoon Shamsoon, Tomofumi Kawakami, Yoshihiro Abiko, Eiji Nakayama, Hiroki Nagayasu
    • Journal Title

      Surgery and Rehabilitation

      Volume: 4 Pages: 1-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer.2020

    • Author(s)
      Nakamura Tomoya、Okui Tatsuo、Hasegawa Kazuaki、Ryumon Shoji、Ibaragi Soichiro、Ono Kisho、Kunisada Yuki、Obata Kyoichi、Masui Masanori、Shimo Tsuyoshi、Sasaki Akira
    • Journal Title

      Oncology Reports

      Volume: 44 Pages: 2547-2558

    • DOI

      10.3892/or.2020.7788

    • NAID

      120007004824

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03889
  • [Journal Article] High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4.2020

    • Author(s)
      Sakamoto Yumi、Okui Tatsuo、Yoneda Toshiyuki、Ryumon Shoji、Nakamura Tomoya、Kawai Hotaka、Kunisada Yuki、Ibaragi Soichiro、Masui Masanori、Ono Kisho、Obata Kyoichi、Shimo Tsuyoshi、Sasaki Akira
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 531 Pages: 422-430

    • DOI

      10.1016/j.bbrc.2020.07.120

    • NAID

      120006890006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03859, KAKENHI-PROJECT-20H03889
  • [Journal Article] Hedgehog Signaling in Organogenesis and the Tumor Microenvironment2020

    • Author(s)
      Shimo Tsuyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 2788-2788

    • DOI

      10.3390/ijms21082788

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Journal Article] Asymptomatic submandibular giant calculus left for 24 years: A case report2020

    • Author(s)
      Shamsoon Karnoon、Harada Fumiya、Yodogawa Shintaro、Takeda Shigehiro、Fujii Saki、Abiko Yoshihiro、Nakayama Eiji、Saito Takashi、Nagayasu Hiroki、Shimo Tsuyoshi
    • Journal Title

      Surgery and Rehabilitation

      Volume: 4 Pages: 1-4

    • DOI

      10.15761/srj.1000163

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Sonic hedgehog regulates bone fracture healing.2020

    • Author(s)
      Takebe Hiroaki、Shalehin Nazmus、Hosoya Akihiro、Shimo Tsuyoshi、Irie Kazuharu
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 21 Pages: 677-677

    • DOI

      10.3390/ijms21020677

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09641, KAKENHI-PROJECT-18K17090, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-18H02999
  • [Journal Article] Circadian production of melatonin in cartilage modifies rhythmic gene expression.2020

    • Author(s)
      Fu Shanqi、Kuwahara Miho、Uchida Yoko、Kondo Sei、Hayashi Daichi、Shimomura Yuji、Takagaki Asami、Nishida Takashi、Maruyama Yusuke、Ikegame Mika、Hattori Atsuhiko、Kubota Satoshi、Hattori Takako
    • Journal Title

      J. Endocrinol.

      Volume: 241 Pages: 161-173

    • DOI

      10.1530/joe-19-0022

    • NAID

      120006801909

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-18K17282, KAKENHI-PROJECT-16K11476, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-18K11016, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19K17399, KAKENHI-PROJECT-17K11641
  • [Journal Article] Disuse atrophy of masticatory muscles after intracranial trigeminal schwannoma resection: A case report and review of literature2020

    • Author(s)
      Elsayed Nagwan、Shimo Tsuyoshi、Tashiro Masayasu、Nakayama Eiji、Nagayasu Hiroki
    • Journal Title

      International Journal of Surgery Case Reports

      Volume: 75 Pages: 23-28

    • DOI

      10.1016/j.ijscr.2020.08.059

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Feasibility of the new TNM classification on the evaluation of progression degree of tongue squamous cell carcinomas:2019

    • Author(s)
      Yoshida Shoko、Kishimoto Koji、Murase Yurika、Ibaragi Soichiro、Yoshioka Norie、Okui Tatsuo、Nagatsuka Hitoshi、Sasaki Akira
    • Journal Title

      J Jpn Soc Oral Oncology

      Volume: 31 Issue: 3 Pages: 151-156

    • DOI

      10.5843/jsot.31.151

    • NAID

      130007710118

    • ISSN
      0915-5988, 1884-4995
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10308
  • [Journal Article] 導帯管による低位埋伏智歯が疑われた1例2019

    • Author(s)
      若林茉梨絵、原田文也、Nagwan Ali Saeed Elsayed、南田康人、石川昌洋、関 姫乃、淀川慎太郎、田代真康、中山英二、志茂 剛、村田 勝、安彦善裕、Berthold H. HELL、永易裕樹
    • Journal Title

      北海道医療大学歯学雑誌

      Volume: 38 Pages: 53-58

    • NAID

      120006821073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma2019

    • Author(s)
      Ryumon S., Okui T.,Kunisada Y., Kishimoto K., Shimo T., Hasegawa K., Ibaragi S., Akiyama K., Thi Thu Ha N., Hassan NMM., Sasaki A.
    • Journal Title

      Oncology Reports

      Volume: 42 Pages: 2611-2621

    • DOI

      10.3892/or.2019.7367

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04405, KAKENHI-PROJECT-18H02999
  • [Journal Article] The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma.2019

    • Author(s)
      Takabatake K, Shimo T, Murakami J, Anqi C, Kawai H, Yoshida S, Wathone Oo M, Haruka O, Sukegawa S, Tsujigiwa H, Nakano K, Nagatsuka H.
    • Journal Title

      Int J Mol Sci.

      Volume: 20(22) Pages: 5779-5779

    • DOI

      10.3390/ijms20225779

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11865, KAKENHI-PROJECT-18K09789, KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-19K19160, KAKENHI-PROJECT-19K24094, KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-16K20577
  • [Journal Article] Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression2019

    • Author(s)
      SHIMO TSUYOSHI、KOYAMA EIKI、OKUI TATSUO、MASUI MASANORI、KUNISADA YUKI、IBARAGI SOICHIRO、YOSHIOKA NORIE、KURIO NAITO、YOSHIDA SHOKO、SASAKI AKIRA、IWAMOTO MASAHIRO
    • Journal Title

      In Vivo

      Volume: 33 Pages: 85-91

    • DOI

      10.21873/invivo.11443

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Journal Article] A rare case of peripheral odontogenic keratocyst in the buccal space: A case report2019

    • Author(s)
      Adhikari BR, Paudel D, Harada F, Morikawa T, Nakayama E, Shimo T, Nagayasu H, Abiko Y
    • Journal Title

      The Dental Journal of Health Sciences University of Hokkaido

      Volume: 38 Pages: 29-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Journal Article] The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma2018

    • Author(s)
      Shoko Yoshida, Tsuyoshi Shimo, Yurika Murase, KiyoFumi Takabatake, Koji Kishimoto, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Hitoshi Nagatsuka AND Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 38 Pages: 955-962

    • DOI

      10.21873/anticanres.12309

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K20579, KAKENHI-PROJECT-16H06992, KAKENHI-PROJECT-16K20577
  • [Journal Article] Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment2018

    • Author(s)
      Eguchi Takanori, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK.
    • Journal Title

      PLoS One

      Volume: 13 Pages: 1-34

    • DOI

      10.1371/journal.pone.0191109

    • NAID

      120006489931

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K17895, KAKENHI-PROJECT-15H05014
  • [Journal Article] Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling2018

    • Author(s)
      Matsumoto Kenichi、Shimo Tsuyoshi、Kurio Naito、Okui Tatsuo、Ibaragi Soichiro、Kunisada Yuki、Obata Kyoichi、Masui Masanori、Pai Pang、Horikiri Yuu、Yamanaka Nobuyuki、Takigawa Masaharu、Sasaki Akira
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 印刷中 Pages: 4352-4360

    • DOI

      10.1002/jcb.26418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16H06992
  • [Journal Article] Analysis of Pathological Activities of CCN Proteins in Bone Metastasis.2016

    • Author(s)
      Shimo T, Yoshioka N, Takigawa M, Sasaki A
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 505-512

    • DOI

      10.1007/978-1-4939-6430-7_42

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014
  • [Journal Article] Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production2016

    • Author(s)
      Shibata A, Ibaragi S, Mandai H, Tsumur a T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 2161-2168

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Detection of sonic hedgehog in a patients undergoing with orthognathic surgery2016

    • Author(s)
      Yuki Kunisada, Tsuyoshi Shimo, Masanori Masui, Norie Yoshioka, Soichiro Ibaragi, Kenichi Matsumoto, Tatsuo Okui, Naito Kurio, Shohei Domae, Koji Kishimoto, Akiyoshi Nishiyama, Akira Sasaki
    • Journal Title

      International Journal of Surgery Open

      Volume: 5 Pages: 1-4

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Tachykinin Receptor 3 Distribution in human oral squamous cell carcinoma2016

    • Author(s)
      Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 6335-6341

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Protocol for measuring angiogenic activities of CCN proteins2016

    • Author(s)
      Shimo T. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014
  • [Journal Article] Cell Biological Assays for Measuring Angiogenic Activities of CCN Proteins.2016

    • Author(s)
      Shimo T and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 239-249

    • DOI

      10.1007/978-1-4939-6430-7_22

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014
  • [Journal Article] The role of Sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction2016

    • Author(s)
      Shimo T, Matsumoto K, Takabatake K, Aoyama E, Takebe Y, Ibaragi S, Okui T, Kurio N, Takada H, Obata K, Pang P, Iwamoto M, Nagatsuka H, Sasaki A.
    • Journal Title

      PLoS One

      Volume: 11(3)

    • DOI

      10.1371/journal.pone.0151731

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-26293428, KAKENHI-PROJECT-16K20577
  • [Journal Article] Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma2016

    • Author(s)
      Masui M, Okui T, Shimo T, Takabatake K, Fukazawa T, Matsumoto K, Kurio N, Ibaragi S, Naomoto Y, Nagatsuka H, Sasaki A.
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 2775-2781

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Analysis of pathological activities of CCN proteins in bone metastasis2016

    • Author(s)
      Shimo T., Yoshioka N., Takigawa M. and Sasaki A.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014
  • [Journal Article] Expression and role of sonic hedgehog in the process of fracture healing with aging2016

    • Author(s)
      Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Kyoichi Obata, Masanori Masui, Pai Pang, Yuu Horikiri, Akira Sasaki
    • Journal Title

      In Vivo

      Volume: 30 Pages: 99-105

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Expression Pattern of Sonic Hedgehog Signaling and Calcitonin Gene Related Peptide in the Socket Healing Process after Tooth Extraction2015

    • Author(s)
      Pai Pang, Tsuyoshi Shimo, Hiroyuki Takada, Kenichi Matsumoto, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 27 Pages: 353-356

    • DOI

      10.1016/j.bbrc.2015.09.139

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Journal Article] Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation2014

    • Author(s)
      Koji Kishimoto, Shoko Yoshida, Soichiro Ibaragi, Norie Yoshioka, Guo-Fu Hu, Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 2113-2122

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24778013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390463
  • [Journal Article] Sonic Hedgehog Regulates Osteoblast Function by Focal Adhesion Kinase Signaling in the Process of Fracture Healing2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Kenichi Matsumoto, Masahiro Iwamoto, Akira Sasaki
    • Journal Title

      PLoS One

      Volume: 8(10)

    • DOI

      10.1371/journal.pone.0076785

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Journal Article] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma2012

    • Author(s)
      Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Yuu Horikiri, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
    • Journal Title

      Oral Oncology

      Volume: (accepted)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Effect of a novel FAK inhibitor TAE226 on the breast cancer associated with bone metastasis2011

    • Author(s)
      Naito Kurio, Tsuyoshi Shimo, Takuya Fukazawa, Munenori Takaoka, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tatsuki Honami, Shinji Hatakeyama, Masahiko Ikeda, Yoshio Naomoto, Akira Sasaki
    • Journal Title

      Experimental Cell Research

      Volume: 317(8) Pages: 1134-1146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrinα1β1 andα2β1-p38 MAPK Signaling2011

    • Author(s)
      Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Sachiko Isowa, Naito Kurio, Hiroki Mandai, Shinichi Kodama, Akira Sasaki.
    • Journal Title

      Anticancer Research

      Volume: 31(4) Pages: 1307-1314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Mechanism of cancer-induced bone destruction : An association of connective tissue growth factor(CTGF/CCN2) in the bone metastasis2011

    • Author(s)
      Tsuyoshi Shimo, Akira Sasaki
    • Journal Title

      Jap Dental Science Review

      Volume: 47(1) Pages: 13-22

    • NAID

      10027849959

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Sonic Hedgehog Signaling Promotes Growth of Oral Squamous Cell Carcinoma Cells Associated with Bone Destruction2011

    • Author(s)
      Tatsuki Honami, Tsuyoshi Shimo, Tatsuo Okui, Naito Kurio, Nur Mohammad Monsur Hassan, Masahiro Iwamoto, Akira Sasaki
    • Journal Title

      Oral Oncology

      Volume: 48(1) Pages: 49-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] PTHrP regulates angiogenesis and bone resorption via VEGF expression2010

    • Author(s)
      Sachiko Isowa, Tsuyoshi Shimo, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Kiminori Matsubara, Nur Mohammad Monsur Hassan, Koji Kishimoto, Akira Sasaki.
    • Journal Title

      Anticancer Research

      Volume: 30(7) Pages: 2755-2767

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells2010

    • Author(s)
      Soichiro Ibaragi, Tsuyoshi Shimo, Masahiro Iwamoto, Nur Mohammad Monsur Hassan, Shinichi Kodama, Sachiko Isowa, and Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 30(12) Pages: 5029-5036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Bone destruction by invading oral squamous carcinoma cells mediated by the transforming growth factor-βsignaling pathway2010

    • Author(s)
      Takeshi Goda, Tsuyoshi Shimo, Yasuto Yoshihama, Nur Mohammad Monsur Hassan, Soichiro Ibaragi, Naito Kurio, Tatsuo Okui, Tatsuki Honami, Koji Kishimoto, Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 30(7) Pages: 2615-2623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Anti-tumor Effect of Temsirolimus against Oral Squamous Cell Carcinoma Associated with Bone Destruction2010

    • Author(s)
      Tatsuo Okui, Tsuyoshi Shimo, Takuya Fukazawa, Naito Kurio, Nur Mohammad Monsur Hassan, Tatsuki Honami, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 9(11)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Journal Article] Connective Tissue Growth Factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.2006

    • Author(s)
      Shimo, T., Kubota, S., et. al.
    • Journal Title

      J Bone and Mineral Research 21

      Pages: 1045-1059

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Journal Article] Pathogenic role of Connective Tissue Growth Factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.2006

    • Author(s)
      Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A, Takigawa M
    • Journal Title

      Journal of Bone and Mineral Research 21

      Pages: 1045-1059

    • Data Source
      KAKENHI-PROJECT-17390536
  • [Journal Article] Pathogenic role of Connective Tissue Growth Factor (CTGF/CCN2) in osteolytic metastasis of breast cancer2006

    • Author(s)
      Shimo, T., Kubota, S., et. al.
    • Journal Title

      J Bone and Mineral Research 21

      Pages: 1045-1059

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Journal Article] Retinoid Signaling Regulates CTGF Expression in Hypertrophic Chondrocytes with Differential Involvement of MAP kinases2005

    • Author(s)
      Tsuyoshi Shimo
    • Journal Title

      Journal of Bone and Mineral Research 20・5(発表予定)

    • Data Source
      KAKENHI-PROJECT-16791239
  • [Presentation] 透明化技術とイメージング解析を用いた扁平上皮癌による骨破壊及び骨形成抑制の検討2022

    • Author(s)
      島谷真梨, 志茂剛
    • Organizer
      第76回日本口腔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] 透明化技術を用いた悪性黒色腫細胞骨浸潤のイメージング解析2021

    • Author(s)
      島谷真梨,志茂 剛
    • Organizer
      第47回日本口腔外科学会北日本支部学術集会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] 癌微小環境におけるHedgehogシグナルの局在とその役割の解析2021

    • Author(s)
      Karnoon Shamsoon,平木大地,横関健治,堀江尚弘,藤井彩貴,斎藤隆史,志茂 剛
    • Organizer
      第66回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] Gli1陽性歯根膜細胞は抜歯窩治癒過程において歯槽骨形成に寄与する2021

    • Author(s)
      藤井彩貴,志茂 剛
    • Organizer
      第66回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] 悪性黒色腫に対するヘッジホッグシグナル阻害剤GANT61の作用機構の解明2021

    • Author(s)
      平木大地,Karnoon Shamsoon,原田文也,永易裕樹,志茂 剛
    • Organizer
      第66回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] Lineage-tracing analysis of Gli1-positive cells in periodontal ligament after tooth extraction2021

    • Author(s)
      Saki Fujii, Hiroaki Takebe, Tsuyoshi Shimo, Akihiro Hosoya
    • Organizer
      第126回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K09995
  • [Presentation] 3D造形支援システムを用いて精密再建を行った下顎歯肉癌の1例2021

    • Author(s)
      原田文也、平木大地、若林茉梨絵、関 姫乃、南田康人、石川昌洋、佐々木智也、淀川慎太郎、中山英二、志茂 剛、安彦善裕、永易裕樹
    • Organizer
      北海道医療大学歯学会第39回学術大会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] 選択的CAMKK2阻害剤の開発に向けたスクリーニング解析2021

    • Author(s)
      島谷真梨,志茂剛,谷村明彦
    • Organizer
      北医療大歯誌. 40(1):77
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Melanoma2021

    • Author(s)
      Karnoon Shamsoon, Hiroaki Takebe, Daichi Hiraki, Mari Shimatani, Saki Fujii, Takashi Saito, Tsuyoshi Shimo
    • Organizer
      北海道医療大学歯学会
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] 診断に苦慮した咀嚼筋腱・腱膜過形成症の1例2020

    • Author(s)
      Nagwan Ali Saeed Elsayed 、志茂 剛 、原田文也、武田成浩、南田康人、若林茉梨絵、佐藤幸平、Karnoon Shamsoon、斎藤隆史、安彦善裕、田代真康、中山英二、川上智史、永易裕樹
    • Organizer
      北海道医療大学歯学会第38回学術大会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] Osteoma of the maxillary sinus: A case report2020

    • Author(s)
      Ariuntsetseg Khurelchuluun, Durga Paudel, Koki Yoshida, Teysuro Morikawa, Fumiya Harada, Jun Sato, Tomoaki Sano, Eiji Nakayama, Tsuyoshi Shimo, Hiroki Nagayasu, Yoshihiro Abiko
    • Organizer
      北海道医療大学歯学会第38回学術大会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] 口腔外より摘出した低位埋伏智歯の1例2020

    • Author(s)
      久原啓資、原田史也、佐野聖子、南田康人、武田成浩、中山英二、奥村一彦、志茂剛、安彦善裕、永易裕樹
    • Organizer
      第46回公益社団法人日本口腔外科学会北日本支部学術集会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] Tooth extraction in a patient with juvenile osteoporosis and cardiovascular disease2020

    • Author(s)
      N Karnoon Shamsoon,Tsuyoshi Shimo,Fumiya Harada,Kazuhiro Miyamoto,Tatsuji Odachi,Masahiro Ishikawa,Tomofumi Kawakami,Takashi Saito, Yoshihiro Abiko, Eiji Nakayama, Hiroki Nagayasu
    • Organizer
      北海道医療大学歯学会第38回学術大会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] 咀嚼筋腱・腱膜過形成症2例-画像所見の差について2020

    • Author(s)
      中山 英二、田代真康、南田康人、武田成浩、佐野友昭、杉浦一考、飯嶋雅弘、吉田光希、志茂 剛、永易裕樹
    • Organizer
      日本歯科放射線学会第1回秋季学術大会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] 炎症性肉芽を伴う導帯管に関連した下顎低位埋伏智歯の2例2019

    • Author(s)
      中山英二、田代真康、若林茉梨絵、原田文也、佐野友昭、杉浦一考、安彦善裕、志茂 剛、永易裕樹
    • Organizer
      日本歯科放射線学会第229回関東地方会・第40回北日本地方会・第27回合同地方会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] モデルサージェリーを用いて再建を行ったエナメル上皮腫の1例2019

    • Author(s)
      原田文也、武田成浩、Nagwan Ali Saeed Elsayed、若林茉梨絵、関 姫乃、南田康人、石川昌洋、佐々木智也、淀川慎太郎、中山英二、奥村一彦、村田 勝、安彦善裕、志茂 剛、永易裕樹
    • Organizer
      第38回日本口腔腫瘍学会総会
    • Data Source
      KAKENHI-PROJECT-19K10273
  • [Presentation] Misdiagnosis of gingival cancer as periodontitis - mechanism of cancer induced jaw bone destruction2019

    • Author(s)
      Tsuyoshi Shimo
    • Organizer
      Euro Dentistry, London, UK
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] Oral squamous cell carcinoma induced jaw bone destruction2019

    • Author(s)
      Tsuyoshi Shimo
    • Organizer
      International Dental Forum, London, UK
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Presentation] Neurokinin B 受容体の口腔扁平上皮癌における発現の検討2016

    • Author(s)
      小畑協一,志茂 剛,高田紘行,高畠清文,奥井達雄,伊原木聰一郎,長塚 仁,佐々木 朗
    • Organizer
      第64回日本口腔科学会中国・四国地方部会
    • Place of Presentation
      山口
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] 骨破壊病変と骨格形成因子2016

    • Author(s)
      志茂 剛
    • Organizer
      第13回日本病理学会カンファレンス
    • Place of Presentation
      六甲山ホテル
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] Hedgehog signaling in jawbone invasion of oral squamous cell carcinoma2015

    • Author(s)
      Tsuyoshi Shimo, Kenichi Matsumoto, Eriko Aoyama, Yuichiro Takebe, Takabatake Kiyofumi, Soichiro Ibaragi, Tatsuo Okui, Naito Kurio, Pang Pai, Hitoshi Nagatsuka, Akira Sasaki
    • Organizer
      ASBMR 2015 Annual Meeting
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2015-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] Expression Pattern of Sonic Hedgehog Signaling and Calcitonin Gene Related Peptide in the Socket Healing Process after Tooth Extraction2015

    • Author(s)
      Pai Pang, Tsuyoshi Shimo, Hiroyuki Takada, Kenichi Matsumoto, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki
    • Organizer
      12th National Conference on Oral and Maxillofacial Surgery in Conjunction with joint of China-Japan Joint Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2015-09-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] The mechanical stimulation mediate the osteoblast differentiation through hedgehog signaling2015

    • Author(s)
      Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, and Akira Sasaki
    • Organizer
      ASBMR 2015 Annual Meeting
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2015-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] Expression and role of sonic hedgehog in oral squamous cell carcinoma induced jaw bone destruction2014

    • Author(s)
      Tsuyoshi Shimo
    • Organizer
      ASBMR Annual Meeting
    • Place of Presentation
      Houston(米国)
    • Year and Date
      2014-09-15
    • Data Source
      KAKENHI-PROJECT-26293428
  • [Presentation] The role of Focal adhesion kinase and Sonic hedgehog on the process of fracture repair2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Masahiro Iwamoto, Naito Kurio, Tatsuo Okui, Akira Sasaki
    • Organizer
      The International Bone and Mineral Society (IBMS)
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Focal adhesion kinase and sonic hedgehog regulate osteoblast and osteoclast function in the process of fracture healing2013

    • Author(s)
      Yuu Horikiri,Tsuyoshi Shimo,Masahiro Iwamoto,Naito Kurio,Tatsuo Okui,Akira Sasaki
    • Organizer
      The 6th International Symposium for Future Technology Creating Better Human Health and Society Strategy to Establish the System for the Developement of Drug
    • Place of Presentation
      Okayama,Japan
    • Year and Date
      2013-02-08
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Focal adhesion kinase and sonic hedgehog regulate osteoblast and osteoclast function in the process of fracture healing2013

    • Author(s)
      Yuu Horikiri, Tsuyoshi Shimo, Masahiro Iwamoto, Naito Kurio, Tatsuo Okui, Akira Sasaki
    • Organizer
      The 6th International Symposium for Future Technology Creating Better Human Health and Society Strategy to Establish the System for the Developement of Drug
    • Place of Presentation
      Okayama
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] The role of Focal adhesion kinase and Sonic hedgehog on the process of fracture repair2013

    • Author(s)
      Yuu Horikiri,Tsuyoshi Shimo,Masahiro Iwamoto,Naito Kurio,Tatsuo Okui,Akira Sasaki
    • Organizer
      The International Bone and Mineral Society (IBMS)
    • Place of Presentation
      Kobe,Japan
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Sonic hedgehog-focal adhesion kinase signaling regulates the process of fracture repair2013

    • Author(s)
      Kenichi Matsumoto, Yuu Horikiri, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Hiromasa Kuroda, Akira Sasaki
    • Organizer
      The third international symposium of medical-dental-pharmaceutical education and research in Okayama
    • Place of Presentation
      Okayama, Japan
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Sonic hedgehog-focal adhesion kinase signaling regulates the process of fracture repair2013

    • Author(s)
      Kenichi Matsumoto,Yuu Horikiri,Tsuyoshi Shimo,Naito Kurio,Tatsuo Okui,Hiromasa Kuroda,Akira Sasaki
    • Organizer
      The third international symposium of medical-dental-pharmaceutical education and research in okayama
    • Place of Presentation
      Okayama,Japan
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Focal adhesion kinaseの骨折早期における骨芽細胞に与える影響2012

    • Author(s)
      堀切 優, 志茂 剛, 栗尾奈愛, 奥井達雄, 佐々木 朗
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] 骨折早期におけるFocal adhesion kinaseの役割2012

    • Author(s)
      堀切 優, 志茂 剛, 栗尾奈愛, 奥井達雄, 佐々木 朗
    • Organizer
      第60回NPO法人日本口腔科学会中国・四国地方部会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24659892
  • [Presentation] Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma2012

    • Author(s)
      Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
    • Organizer
      The 5th International Symposium for Future Technology Creating Better Human Health and Society
    • Place of Presentation
      Okayama
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Presentation] A Novel Focal Adhesion Kinase Inhibitor TAE226 Suppresses Parathyroid Related Protein Induced Hypercalcemia and Reduced Osteoclast Activation2010

    • Author(s)
      Naito Kurio, Tsuyoshi Shimo, Nur Mohammad Monsur Hassan, Tatsuo Okui, Tatsuki Honami, Shinji Hatakeyama, Munenori Takaoka, Yoshio Naomoto, Akira Sasaki
    • Organizer
      The 3rd International Symposium for Future Technology Creating Better Human Health and Society
    • Place of Presentation
      Okayama
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Presentation] Inhibition of Focal Adhesion Kinase Suppresses Breast Cancer Induced Bone Metastasis2009

    • Author(s)
      Naito Kurio, Tsuyoshi Shimo, Munenori Takaoka, Tatsuo Okui, Norie Yoshioka, Nur Mohammad Monsur Hassan, Shinji Hatakeyama, Yoshio Naomoto, Akira Sasaki
    • Organizer
      The American Society for Bone and Mineral Research 31st Annual Meeting
    • Place of Presentation
      Colorado, USA
    • Data Source
      KAKENHI-PROJECT-21689050
  • [Presentation] The role of transforming growth factor-β (TGF-β) signaling in oral squamous cell carcinoma, and experimental therapeutic strategy for cancer induced bone destruction2008

    • Author(s)
      Goda, K., Shimo, T., et. al.
    • Organizer
      62h Annual Meeting of Japanese Stomatological Society
    • Place of Presentation
      Hakata, Japan.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Analysis of regulation and mechanism of oral cancer induced bone destruction by inhibition of transforming growth factor-β (TGF-β) signaling2007

    • Author(s)
      Goda, K., Shimo, T., et. al.
    • Organizer
      1st Japanese Meeting of CCN family
    • Place of Presentation
      Okayama Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Analysis of expression and mechanisms of connective tissue growth factor in osteolytic mandibular squamous cell carcinoma2007

    • Author(s)
      Shimo, T., Kubota, S., et. al.
    • Organizer
      1st Japanese Meeting of CCN Family
    • Place of Presentation
      Okayama Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Sonic Hedgehog Function in Fracture Repair and Osteoclast Formation2007

    • Author(s)
      Tsuyoshi Shimo
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, HI, USA
    • Year and Date
      2007-09-17
    • Data Source
      KAKENHI-PROJECT-18689049
  • [Presentation] 口腔扁平上皮癌顎骨破壊における結合組織増殖因子の発現とそのメカニズムの解析2007

    • Author(s)
      志茂 剛, 他
    • Organizer
      第52回日本口腔外科学会総会
    • Place of Presentation
      名古屋(愛知県)
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Role and Mechanism of Connective Tissue Growth Factor (CCN2/CTGF) Induction in Osteolytic Metastasis of Breast Cancer2007

    • Author(s)
      Shimo, T., et. al.
    • Organizer
      4th International Workshop on The CCN Family of Genes
    • Place of Presentation
      Okayama (Japan)
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Role and mechanism of connective tissue growth factor (CCN2/CTGF) induction in osteolytic metastasis of breast cancer2007

    • Author(s)
      Shimo, T., Kubota, S., et. al.
    • Organizer
      4th International Workshop on The CCN Family of Genes
    • Place of Presentation
      Okayama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] Analysis of expression and mechanisms of connective tissue growth factor in osteolytic mandibular squamous cell carcinoma2007

    • Author(s)
      Shimo, T., Goda, K., et. al.
    • Organizer
      52nd Annual Meeting of Japanese Society for Oral and Maxillofacial Surgeons
    • Place of Presentation
      Nagoya Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • [Presentation] 癌顎骨切除標本におけるCCN2の臨床病理学的検討2007

    • Author(s)
      志茂 剛, 他
    • Organizer
      第1回日本CCNファミリー研究会
    • Place of Presentation
      岡山市(岡山県)
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390536
  • 1.  SASAKI Akira (00170663)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 11 results
  • 2.  YOSHIOKA Norie (50362984)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 5 results
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    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 6 results
    # of Collaborated Products: 8 results
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    # of Collaborated Products: 8 results
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    # of Collaborated Products: 4 results
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    # of Collaborated Products: 6 results
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    # of Collaborated Products: 6 results
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    # of Collaborated Products: 6 results
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    # of Collaborated Products: 1 results
  • 12.  KURIO Naito (80622141)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
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    # of Collaborated Products: 3 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
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    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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  • 24.  ONO Mitsuaki (60613156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
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    # of Collaborated Products: 4 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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