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Kiso Yoshiaki  木曽 良明

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… Alternative Names

KISO Yoshiaki  木曽 良明

木曾 良明  キソ ヨシアキ

木曽 良明  キソ ヨシアキ

Less
Researcher Number 40089107
Other IDs
External Links
Affiliation (Current) 2025: 長浜バイオ大学, バイオサイエンス学部, 客員教授
Affiliation (based on the past Project Information) *help 2013 – 2015: 長浜バイオ大学, バイオサイエンス学部, 客員教授
2011 – 2012: 長浜バイオ大学, バイオサイエンス学部, 教授
2011: 長浜バイオ大学, バイオサイエンス学部, 客員教授
1990 – 2010: 京都薬科大学, 薬学部, 教授
1996: Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, Professor, 薬学部, 助教授 … More
1994: 京都薬科大, 薬学部, 教授
1987: 京都薬科大学, 薬学部, 教授
1986: 京薬大, 薬学部, 教授 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Chemical pharmacy / 医薬分子機能学 / Drug development chemistry / Bioorganic chemistry
Except Principal Investigator
Drug development chemistry / 医薬分子機能学 / Biological pharmacy / Biomolecular chemistry / Chemical biology / Bioorganic chemistry
Keywords
Principal Investigator
ペプチド合成 / ドラッグデザイン / HIVプロテアーゼ阻害剤 / 酵素阻害剤 / 基質遷移状態誘導体 / アスパラギン酸プロテアーゼ / 抗ウイルス薬 / 分子認識 / 酵素・阻害剤複合体 / ペプチドミメティック … More / エイズ治療薬 / HIVプロテアーゼ / 薬剤耐性 / 基質遷移状態 / 抗エイズ薬 / 酵素阻害剤複合体 / X線結晶構造解析 / ペプチドミミック / プロテアーゼ阻害剤 / Peptide Synthesis / コンフォメーション解析 / Anti-HIV Activity / Enzyme Inhibitor / Substrate Transition State / AIDS Therapeutics / Molecular Recognition / プラスメプシン / セクレターゼ / アルツハイマー病 / 酵素活性中心 / 抗HIV活性 / コンフォーメーション解析 / 効率的固相合成法 / 分子設計 / HIV Protease Inhibitor / β-セクレターゼ / マラリア / コンフォメーション / 薬剤耐性ウイルス / 基質遷移状態概念 / HIV Protease / Anti-AIDS Drug / Drug Resistant Virus / X-ray Crystallography / Conformational Analysis / Substrate Transition State Analog / Enzyme・Inhibitor Complex / HIV Protease Inhibitors / HIV protease inhibitor / ANP / 構造活性相関 / 心房性ナトリウム利尿ホルモン / プロテアーゼ / アミロイド産生 / 老化 / 抗ATL薬 / HTLVプロテアーゼ阻害剤 / リ-ドオプチマイゼーション / キノスタチン-272 / HTLV-1プロテアーゼ / レニン阻害剤 / Enemy metabolism / Antioxidation / Iron sulfur cluster / Electron transport / Parasitism / Entamoeba histolytica / AIDS / エネルギー代謝 / 抗酸化 / 鉄硫黄クラスター / 電子伝達 / 寄生 / 赤痢アメーバ / HTLV-1 protease / adult T-cell leukemia / plasmepsin / β-secretase / Alzheimer's disease / aspartic protease / enzyme inhibitors / 難病治療薬 / 成人T細胞白血病 / プロドラック / プロドラッグ / Double Drug / HIV protease / コンフォンメーション解析 / Peptide synthesis / 薬物代謝 / キノスタチン / 抗HIV薬 / peptide synthesis / prodrug / kynostatin / drug design / anti-HIV drug / activiral drug / peptide mimic / anti-AIDS drug / クリックペプチド / クリプタイド / ss-セクレターゼ / BACE1 / エイズ / プラスメプシンII / ダブルドラッグ / 固相合成 / ウイルスプロテアーゼ / 構造規制 / NMR / 分子モデリング / ATL治療薬 / 高血圧症治療薬 / ペプチドmimic / HIVプロテア-ゼ / レニン / アスパラギン酸プロテア-ゼ … More
Except Principal Investigator
自然炎症 / 自然免疫 / 好中球 / Gタンパク質共役受容体 / 生理活性ペプチド / マイトクリプタイド / クリプタイド / MAPキナーゼ / 分子設計 / molecular design / medicinal chemistry / molecular function / diketopiperazine derivatives / total synthesis / anti-cancer drug / inhibition of tubulin polymerization / phenylahistin / 抗ガン剤 / チューブリン阻害剤 / 創薬 / 抗癌剤 / 創薬化学 / 分子機能 / ジケトピペラジン誘導体 / 全合成 / 抗がん剤 / チューブリン重合阻害 / フェニラヒスチン / p38 MAP kinase / TGF-beta Superfamily / Bone Morphogenetic Protein / Nerve Growth Factor / Hepatocyte Growth Factor / ERK MAP kinases / Cell Differentiation / Cell Growth Control / 骨形成因子 / 細胞骨格 / 転写因子 / 核移行 / 分化因子 / 増殖因子 / p38MAPキナーゼ / TGF-βスーパーファミリー / 多機能因子 / 血小板由来増殖因子 / 肝細胞増殖因子 / 神経成長因子 / ERK MAPキナーゼ / 細胞増殖・分化 / 拮抗阻害薬 / 拮抗阻害ペプチド / 中和抗体 / アロフェニルノルスタチン / ロピナビル / 薬剤耐性 / HIVプロテアーゼ阻害剤 / エイズ / HIV / 治療薬 / 分子認識 / バイオインフォマティクス / Gタンパク質 / 環状ペプチド / 自己リン酸化阻害 / 二量化アーム模倣ペプチド / ジスルフィド架橋形成 / キャピラリー電気泳動 / 表面プラズモン共鳴 / コンビナトリアル合成 / レトロインバーソ / 親和性増強 / 二量化阻害環状ペプチド / EGFレセプター / ループ構造模倣環状ペプチド / 二量化阻害 / レセプター創薬 / 医薬分子設計 / チロシンリン酸化 / MAPキナーゼカスケード / MAPキナーゼ・キナーゼ / ヒトがん細胞株 / 細胞がん化 / 重点領域 / 構造活性相関 / ペプチド三次構造 / 生体内信号 / ペプチド合成 / ペプチド科学 / 生体機能性ペプチド / ハービマイシンA / TPA / アンチセンスオリゴヌクレオチド / 血管新生阻害 / がん転移 / フィブロネクチン / レチノイド / G-蛋白質 / 増階シグナル伝達 / 細胞増殖因子 / 細胞骨格蛋白質 / MAPキナ-ゼ / 微小管結合蛋白質 / セリン・スレオニンキナ-ゼ / チロシンキナ-ゼ / チロシンリン酸化蛋白質 Less
  • Research Projects

    (52 results)
  • Research Products

    (262 results)
  • Co-Researchers

    (38 People)
  •  Cryptides: Identification of novel cryptides and elucidation of their physiological roles

    • Principal Investigator
      Mukai Hidehito
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      Nagahama Institute of Bio-Science and Technology
  •  薬剤耐性HIVプロテアーゼに対する高活性阻害剤の設計研究

    • Principal Investigator
      木村 徹
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  Design and Medicinal Chemistry Research on Therapeutics ofDifficult Diseases based on Molecular RecognitionPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Nagahama Institute of Bio-Science and Technology
      Kyoto Pharmaceutical University
  •  Development of peptide inhibitors against the EGF receptor based on its structural properties.

    • Principal Investigator
      SAITO Kazuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
      Kyoto Pharmaceutical University
  •  Cryptides : elucidation of regulatory mechanisms by functional peptides hidden in protein structures

    • Principal Investigator
      MUKAI Hidehito
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Nagahama Institute of Bio-Science and Technology
      Kyoto Pharmaceutical University
  •  Design and medicinal chemistry research on drugs for difficult diseases based on molecular recognition of proteasesPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  アルツハイマー病克服をめざしたアミロイドセクレターゼ制御分子のデザインと合成Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  Biosyrdiesis of iron-sulfur proteins in Enlanoeba histotyricaPrincipal Investigator

    • Principal Investigator
      NOZAKI Tomoyoshi, 木曽 良明
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Gunma University
      Kyoto Pharmaceutical University
  •  アルツハイマー病克服をめざしたアミロイドセクレターゼ制御分子のデザインと合成Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  病原体酵素の分子認識に基づくエイズ・マラリアの治療薬開発と薬剤耐性克服研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  Design and development of therapeutic drugs for intractable diseases based on molecular recognition of aspartic proteasesPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  アルツハイマー病克服をめざしたアミロイドセクレターゼ制御分子のデザインと合成Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVをターゲットとするダブルドラッグ型阻害剤のデザインと開発研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  プロテアーゼ・リガンド複合体の動的構造解析に基づく阻害剤のデザインPrincipal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVをターゲットとするハイブリッド型阻害剤のデザインと開発研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  Design of resistance-surmountable HIV protease inhibitors based on molecular recognition analysis of mutant proteasePrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto Pharmaceutical University
  •  Molecular Function of Naturally Occurring Anti-microtubule Agent Phenylahistin (Determination of Structural Components Necessary for the Anti-microtubule activity t and Molecular Design for Drugs)

    • Principal Investigator
      HAYASHI Yoshio
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  プロテアーゼ・リガンド複合体の動的構造解析に基づく阻害剤のデザインPrincipal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto Pharmaceutical University
  •  薬剤耐性HIVと変異プロテアーゼの機能解析によるウイルス病原性の分子機構解明-HIVと人類の共生をめざして-Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  Study on strategy for AIDS drugs against mutant virusesPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO PHARMACEUTICAL UNIVERSITY
  •  変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  Molecular design of HIV protease inhibitors restricted to active conformationPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO PHARMACEUTICAL UNIVERSITY
  •  プロテアーゼ・阻害剤複合体の構造解析に基づく阻害剤の構造活性相関研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼ活性中心をターゲットとしてデザインされた阻害剤の開発Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  薬剤耐性HIVと変異プロテアーゼの機能解析によるウイルス病原性の分子機構解明Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  Joint Study on AIDS Drug Based on HIV ProteasePrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYOTO PHARMACEUTICAL UNIVERSITY
  •  Molecular design and synthesis of HIV protease inhibitors with structurally constrained active conformationPrincipal Investigator

    • Principal Investigator
      KISO Yoshiki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
  •  Role of the ERK MAP Kinase Cascade in the Regulation of Cell Proliferation and Differentiation.

    • Principal Investigator
      KOHNO Michiaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagasaki University
      Gifu Pharmaceutical University
  •  プロテアーゼ・阻害剤複合体の構造解析に基づく阻害剤の構造活性相関研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  MAPキナーゼの恒常的活性化がヒトがん発生の直接的な原因となる可能性の検討

    • Principal Investigator
      河野 通明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu Pharmaceutical University
  •  ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザインPrincipal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  変異HIVに対する阻害剤のデザインとウイルス病原性の分子機構解明への展開Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  活性型コンフォメーションに構造規制されたHIVプロテアーゼ阻害剤の分子設計Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto Pharmaceutical University
  •  Molecular design of AIDS therapeutics based on molecular recognition of enzymes.Principal Investigator

    • Principal Investigator
      KISO Yoshiaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyoto Pharmaceutical University
  •  プロテアーゼ・阻害剤複合体の構造解析に基づく阻害剤の構造活性相関研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  非細胞傷害性抗がん化合物の合成と作用解析

    • Principal Investigator
      松田 彰
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザインPrincipal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto Pharmaceutical University
  •  機能性ペプチドの分子設計における新展開

    • Principal Investigator
      宗像 英輔
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      University of Tsukuba
  •  ATL治療薬をめざしたHTLV-1プロテアーゼ阻害剤のデザインPrincipal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼの基質遷移状態概念に基づく医薬品の分子設計Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto Pharmaceutical University
  •  Joint study on protease-targeted anti-AIDS drugsPrincipal Investigator

    • Principal Investigator
      KISO Yoshiaki, 木曾 良明
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kyoto Pharmaceutical University
  •  アスパラギン酸プロテアーゼの基質遷移状態概念に基づく阻害剤の分子設計と合成研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
  •  細胞増殖因子作用における41K,43K蛋白質チロシンリン酸化反応促進の役割ー41K,43K蛋白質のcDNAクロ-ニング

    • Principal Investigator
      KOHNO Michiaki
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Gifu Pharmaceutical University
  •  アスパラギン酸プロテア-ゼの基質遷移状態概念に基づく阻害剤の分子設計と合成研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
  •  心房性ナトリウム利尿ホルモン関連ペプチドの合成及びその構造活性相関研究Principal Investigator

    • Principal Investigator
      木曽 良明
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
  •  心房性ナトリウム利尿ホルモン関連ペプチドの合成及びその構造活性相関研究Principal Investigator

    • Principal Investigator
      木曾 良明
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] ペプチド医薬の最前線2013

    • Author(s)
      木曽良明
    • Total Pages
      240
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] Handbook of Proteolytic Enzymes3rd Edition.2013

    • Author(s)
      Jeffrey-Tri Nguyen, Yoshiaki Kiso
    • Publisher
      Human T-cell leukemia virus type I (HTLV-I) retropepsin.
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] 遺伝子医学MOOK21号最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)O-アシルイソペプチドの合成.2012

    • Author(s)
      相馬洋平・木曽良明
    • Publisher
      メディカル・ドゥ
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] クリプタイド:タンパク質に隠された新しい生理活性ペプチド-その発見と存在意義および効率的スクリーニング。遺伝子医学MOOK21号最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)2012

    • Author(s)
      向井秀仁・木曽良明
    • Publisher
      メディカル・ドゥ
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] 最新ペプチド合成技術とその創薬研究への応用2012

    • Author(s)
      濱田芳男・木曽良明
    • Publisher
      メディカル・ドゥ
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] アルツハイマー病治療薬をめざしたBACE1阻害剤の設計と合成.遺伝子医学MOOK21号最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)2012

    • Author(s)
      濱田芳男・木曽良明
    • Publisher
      メディカル・ドゥ
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] 遺伝子医学MOOK 21号最新ペプチド合成技術とその創薬研究への応用2012

    • Author(s)
      木曽良明
    • Total Pages
      316
    • Publisher
      メディカル・ドゥ
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] Amino Acids Peptides & Proteins in Organic Chemistry, Vol. 4 (ed. By Andrew Hughes) Wiley-VCH2011

    • Author(s)
      Zyta Ziora, Mariusz Skwarczynski, Yoshiaki Kiso
    • Publisher
      Medicinal chemistry of α-hydroxy-SS- amino acids.
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] Methods and Principles in Medicinal Chemistry, Volume 45 (Aspartic Acid Proteases as Therapeutic Targets)2010

    • Author(s)
      Adam J. Ruben, Yoshiaki Kiso
    • Publisher
      The plasmepsin family as antimalarial drugtargets.
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] Click peptides : design and applications2009

    • Author(s)
      Y. Kiso, A. Taniguchi, Y. Sohma
    • Publisher
      Wiley Encyclopedia of Chemical Biology(Ed.T.P.Begley)
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] Wiley Encyclopedia of Chemical Biology(ed. Tadhg P. Begley)2009

    • Author(s)
      Y. Kiso, A. Taniguchi, Y. Sohma
    • Publisher
      Click peptides : design and applications
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] Wiley Encyclopedia of Chemical Biology2009

    • Author(s)
      Yoshiaki Kiso
    • Publisher
      Wiley & Sons Inc.
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] Viral Proteases and Antiviral Protease Inhibitor Therapy: Proteases in Biology and Disease (Uwe Lendeckel & Nigel M. Hooper, eds.)2009

    • Author(s)
      Jeffrey-Tri Nguyen, Yoshiaki Kiso
    • Publisher
      Rational Drug Design of HTLV-1 Protease Inhibitors.
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] Wiley Encyclopedia of Chemical Biology, Volume 1 (Tadhg P. Begley, Chief Advisor)2009

    • Author(s)
      Yoshiaki Kiso, Atsuhiko Taniguchi, Youhei Sohma
    • Publisher
      Click Peptides: Design and Applica- tions.
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Book] 遺伝子医学MOOK, 8「ペプチドと創薬」2007

    • Author(s)
      木曽良明、濱田芳男
    • Publisher
      プロテアーゼインヒビターからの創薬
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] 化学フロンティア19.創薬をめざす有機合成戦略-進化する医薬品づくり2007

    • Author(s)
      木曽 良明
    • Publisher
      化学同人
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] 化学フロンティア19, 創薬をめざす有機合成戦略-進化する医薬品づくり(宍戸宏造、新藤充編)2007

    • Author(s)
      木曽良明、日高興士
    • Publisher
      ペプチドと創薬研究
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Book] 第19回大学と科学公開シンポジウム講演収録集:アルツハイマー病:治療の可能性を探る2005

    • Author(s)
      木曽 良明
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Journal Article] Mitochondrial protein-derived cryptides: are endogenous N-formylated peptides including mitocryptide-2 components of mitochondrial damage-associated molecular patterns?2016

    • Author(s)
      Marutani, T., Hattori, T., Tsutsumi, K., Koike, Y., Harada, A., Noguchi, K., Kiso, Y., and Mukai, H.
    • Journal Title

      Biopolymers: Peptide Science

      Volume: 106 Issue: 4 Pages: 580-587

    • DOI

      10.1002/bip.22788

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971, KAKENHI-PROJECT-16J11227, KAKENHI-PROJECT-16K01923
  • [Journal Article] Mitocryptide-3: characterization of its receptor molecules2016

    • Author(s)
      Marutani, T., Nakashima, K., Tsutsumi, K., Hattori, T., Nishino, K., Shimizu, T., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2015 Pages: 251-252

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Effects of mitocryptide-1 on inflammatory cells in mice2016

    • Author(s)
      Hattori, T., Morikawa, H., Marutani, T., Tsutsumi, K., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2015 Pages: 253-254

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-12015

    • Author(s)
      Hattori, T., Nakashima, K., Marutani, T., Kiso, Y., Nishi, Y., and Hidehito Mukai, H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Functional analysis of mitocryptides with their neutralizing monoclonal antibodies2015

    • Author(s)
      Hattori, T., Araki, R., Watanabe, K., Marutani, T., Nakashima, K., Nishi, Y., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptides

      Volume: 2014 Pages: 360-361

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Mitocryptide-2: structure-activity relationships for the elucidation of ligand recognition mechanisms of formyl-peptide receptor like 12015

    • Author(s)
      Marutani, T., Hattori, T., Koike, Y., Harada, A., Watanabe, K., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptides

      Volume: 2014 Pages: 6-8

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Structure-activity relationships of mitocryptide-3 on the activation of neutrophilic cells2015

    • Author(s)
      Nakashima, K., Marutani, T., Hattori, T., Noguchi, K., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2014 Pages: 175-176

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Successful acquisition of a neutralizing monoclonal antibody against a novel neutrophil-activating peptide, mitocryptide-12015

    • Author(s)
      Hattori, T., Nakashima, K., Marutani, T., Kiso, Y., Nishi, Y., and Mukai, H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 463 Issue: 1-2 Pages: 54-59

    • DOI

      10.1016/j.bbrc.2015.05.016

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Investigation of ligand recognition mechanisms of receptors for mitocryptide-12015

    • Author(s)
      Tsutsumi, K., Marutani, T., Hattori, T., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2014 Pages: 177-178

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Mitocryptides: Elucidation of their biological functions with their monoclonal antibodies2014

    • Author(s)
      Hattori, T., Araki, R., Nakashima, K., Marutani, T., Ogino, S., Koike, Y., Hirooka, Y., Miyake, N., Murata, K., Watanabe, K., Kiso, Y., Nishi, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2013 Pages: 247-248

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Aggregation inhibitor of amyloid-β peptide based on O-acyl isopeptide2014

    • Author(s)
      Kawashima, H., Sohma, Y., Nakanishi, T., Kitamura, H., Mukai, H., Yamashita, M., Akaji, K., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: 2013 Pages: 101-104

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Endogenous N-formylated cryptides: Investigation of their biological functions2014

    • Author(s)
      Marutani, T., Hattori, T., Koike, Y., Harada, A., Watanabe, K., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2013 Pages: 249-250

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide.2013

    • Author(s)
      川島 浩之
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 21 Issue: 21 Pages: 6323-6327

    • DOI

      10.1016/j.bmc.2013.08.062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J08493, KAKENHI-PROJECT-25350971
  • [Journal Article] クリプタイド:タンパク質に隠された新しい機能ペプチド2013

    • Author(s)
      向井秀仁,木曽良明
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 71 Pages: 18-22

    • NAID

      10031140296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Identification and structure-activity studies of novel cryptides hidden in mitochondrial proteins2013

    • Author(s)
      Mukai, H., Hokari, Y., Seki, T., Fukamizu, A., and Kiso, Y.
    • Journal Title

      Peptides: Across the Pacific

      Volume: 2013 Pages: 314-315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Functional analysis of mitocryptides with their monoclonal antibodies2013

    • Author(s)
      Hattori, T., Shirota, S., Marutani, T., Kiso, Y., Nishi, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: 2012 Pages: 277-278

    • NAID

      10031161627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Journal Article] Comparative properties of Aβ1-42, Aβ11-42, and [Pyr^<11>]Aβ11-42 generated from O-acyl isopeptides2013

    • Author(s)
      相馬洋平
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 23巻 Issue: 5 Pages: 1326-1329

    • DOI

      10.1016/j.bmcl.2012.12.082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J08493, KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-25350971
  • [Journal Article] Isolation and Identification of Novel Neutrophil-Activating Cryptides Hidden in Mitochondrial Cytochromec.2012

    • Author(s)
      Yoshinori Hokari, Tetsuo Seki, Hiroko Nakano, Yuko Matsuo, Akiyoshi Fukarnizu, Eisukc Munekata, Yoshiaki Kiso, Hidehito Mukai
    • Journal Title

      Protein Peptide Letters

      Volume: 19 Issue: 6 Pages: 680-687

    • DOI

      10.2174/092986612800494048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Quantitative analyses of disulfide bond formation in proteins using^<18> O-labeled peptide standards2012

    • Author(s)
      Kazuki Saito, Hiromasa Uchimura, YusamKim, Itsuki Yasuo, Shizuyo Koide-Yoshida, Takaaki Mizuguchi, Hiroshi Kataoka, Yoshiaki Kiso
    • Journal Title

      Pept. Sci. 2011

      Pages: 77-78

    • NAID

      10030204037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome c2012

    • Author(s)
      Hokari, Y., Seki, T., Nakano, H., Matsuo, Y., Fukamizu, A., Munekata, E., Kiso, Y., and Mukai, H
    • Journal Title

      Protein and Peptide Letters

      Volume: Vol.19 Pages: 680-687

    • URL

      http://www.benthamdirect.org/pages/content.php?PPL/2012/00000019/00000006/0015E.SGM

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Novel neutrophil-activating cryptides hidden in mitochondrial cytochrome c : identification and structure-activity studies2012

    • Author(s)
      Hokari, Y., Seki, T., Nakano, H., Fukamizu, A., Munekata, E., Kiso, Y., and Mukai, H.
    • Journal Title

      Peptide Science

      Volume: Vol.2011 Pages: 61-62

    • NAID

      10030204009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors.2012

    • Author(s)
      Yoshio Hamada, Yoshiaki Kiso
    • Journal Title

      Expert Opinion on Drug Discovery

      Volume: 7(10) Issue: 10 Pages: 903-922

    • DOI

      10.1517/17460441.2012.712513

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23590137
  • [Journal Article] BACE1 inhibitor peptides: Can an infinitely small kcat value turn the substrate of an enzyme into its inhibitor?2012

    • Author(s)
      Yoshio Hamada, Shoichi Ishiura, Yoshiaki Kiso
    • Journal Title

      ACS Med Chem Lett.

      Volume: 3(3) Issue: 3 Pages: 193-197

    • DOI

      10.1021/ml2002373

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23590137
  • [Journal Article] Tripeptidic BACE1 inhibitors devised by in-silico conformational structure- based design.2012

    • Author(s)
      Yoshio Hamada, Harichandra D. Tagad, Yoshinori Nishimura, Shoichi Ishiura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22(2) Issue: 2 Pages: 1130-1135

    • DOI

      10.1016/j.bmcl.2011.11.102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23590137
  • [Journal Article] クリプタイド:タンパク質に隠された新しい生理活性ペプチド.その発見と存在意義および効率的スクリーニング2012

    • Author(s)
      向井秀仁、木曽良明
    • Journal Title

      遺伝子医学MOOK

      Volume: Vol.21 Pages: 298-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Intact-cell-based surface plasmon resonance measurements for ligand affinity evaluation of a membrane receptor2012

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Hiroshi Kataoka, Kenichi Akaji, YoshiakiKiso, Kazuki Saito
    • Journal Title

      Anal. Biochem

      Volume: 420 Pages: 185-187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Cryptides : non-classical bioactive peptides hidden in protein structures2011

    • Author(s)
      Mukai, H., Seki, T., Hokari, Y., Fukamizu, A., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2010 Pages: 29-29

    • NAID

      130004952275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Quantitative evaluation of refolding conditions for a disulfide-bond-containing protein using a concise^<18> O-labeling technique2011

    • Author(s)
      Hiromasa Uchimura, Yusam Kim, TakaakiMizuguchi, Yoshiaki Kiso, Kazuki Saito
    • Journal Title

      Protein Sci

      Volume: 20 Pages: 1090-1096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] "Click Peptide" Concept: O-Acyl Isopeptide of Islet Amyloid Poly- peptide As a non-aggregative precursor molecule.2011

    • Author(s)
      Taku Yoshiya, Ayano Higa, Naoko Abe, Fukue Fukao, Tomomi Kuruma, Youhei Sohma, Yoshiaki Kiso
    • Journal Title

      ChemBioChem.

      Volume: 12(8) Issue: 8 Pages: 1216-1222

    • DOI

      10.1002/cbic.201100025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118
  • [Journal Article] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using a plug-plug affinity capillary electrophoresis technique2011

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Journal Title

      Pept. Sci. 2010

      Volume: 287

    • NAID

      10028238217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Isotope labeling-assisted quantitative evaluation of refolding conditions of a recombinant disulfide protein2011

    • Author(s)
      Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
    • Journal Title

      Pept. Sci. 2010

      Volume: 148

    • NAID

      10028237630

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Cryptides and their accumulative signaling : a novel regulatory mechanism by functional peptides hidden in protein structures2011

    • Author(s)
      Mukai, H. and Kiso, Y.
    • Journal Title

      Peptides

      Volume: Vol.2011 Pages: 314-315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] The E22SS-type mutant of amyloid SS peptide (ASS) adopts distinct selfassembly mechanisms from wild- type ASS.2011

    • Author(s)
      Youhei Sohma, Hui Wang, Atsuhiko Taniguchi, Yuta Hirayama, Taeko Kakizawa, Hidehito Mukai, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Issue: 12 Pages: 3787-3792

    • DOI

      10.1016/j.bmc.2011.04.056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-22790119
  • [Journal Article] Intact cell-based SPR analyses of interactions between EGF and its receptor2011

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
    • Journal Title

      Pept. Sci. 2010

      Volume: 98

    • NAID

      10028237415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Click peptide : application to E22-type mutant of amyloid2011

    • Author(s)
      Wang, H., Sohma, Y., Taniguchi, A., Hirayama, Y., Kakizawa, T., Mukai, H., and Kiso, Y.
    • Journal Title

      peptide, Peptide Science

      Volume: Vol.2010 Pages: 221-221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1. Biochem.2011

    • Author(s)
      Tesuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso, Hidehito Mukai
    • Journal Title

      Biophys. Res. Commun.

      Volume: 404(1) Issue: 1 Pages: 482-487

    • DOI

      10.1016/j.bbrc.2010.12.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014
  • [Journal Article] Crystal structure of the free and inhibited plasmepsin I from Plasmodium falciparum.2011

    • Author(s)
      Prasenjit Bhaumik, Yasumi Horimoto, Huogen Xiao, Alexander Wlodawer, Yoshiaki Kiso, Rickey Y. Yada, Alla Gustchina
    • Journal Title

      J. Structural Biol.

      Volume: 175(1) Issue: 1 Pages: 73-84

    • DOI

      10.1016/j.jsb.2011.04.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Click peptide : In situ production of pyroGlu-Abeta from the O-acyl isopeptide2011

    • Author(s)
      Yamazaki, M., Sohma, Y., Taniguchi, A., Hirayama, Y., Furuya, M., Mukai, H., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2010 Pages: 210-210

    • NAID

      10028237887

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.2011

    • Author(s)
      Jeffrey-Tri Nguyen, Keiko Kato, Henri-Obadja Kumada, Koushi Hidaka, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 21 Issue: 6 Pages: 1832-1837

    • DOI

      10.1016/j.bmcl.2011.01.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23790145
  • [Journal Article] Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles.2011

    • Author(s)
      Jeffrey-Tri Nguyen, Keiko Kato, Koushi Hidaka, Henri-Obadja Kumada, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 21 Issue: 8 Pages: 2425-2429

    • DOI

      10.1016/j.bmcl.2011.02.066

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23790145
  • [Journal Article] 'Click peptide' using production of monomer Ab from the O-acyl isopeptide: Application to assay system of aggregation inhibitors and cellular cytotoxicity.2011

    • Author(s)
      Youhei Sohma, Yuta Hirayama, AtsuhikoTaniguchi, Hidehito Mukai, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Issue: 5 Pages: 1729-1733

    • DOI

      10.1016/j.bmc.2011.01.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014, KAKENHI-PROJECT-22790118
  • [Journal Article] Use of O-acyl isopeptides to identify new functions of amyloid. peptides2011

    • Author(s)
      Sohma, Y., Taniguchi, A., Hirayama, Y., Wang, H., Yamazaki, M., Mukai, H., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2010 Pages: 54-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide.2011

    • Author(s)
      Youhei Sohma, Hitomi Kitamura, Hiroyuki Kawashima, Hironobu Hojo, Masayuki Yamashita, Kenichi Akaji, Yoshiaki Kiso
    • Journal Title

      Tetrahedron Letters

      Volume: 52(52) Issue: 52 Pages: 7146-7148

    • DOI

      10.1016/j.tetlet.2011.10.116

    • NAID

      10030204148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-23380065
  • [Journal Article] Development of L40I HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate.2011

    • Author(s)
      Henri-Obadja Kumada, Jeffrey-Tri Nguyen, Keiji Nishiyama, Taeko Kakizawa, Yasuhiro Arii, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso
    • Journal Title

      J. Peptide Science

      Volume: 17(8) Issue: 8 Pages: 569-575

    • DOI

      10.1002/psc.1375

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119, KAKENHI-PROJECT-23790145
  • [Journal Article] Structural insights into activation and inhibition of histo-aspartic protease (HAP) from Plasmodium falciparum.2011

    • Author(s)
      Prasenjit Bhaumik, Huogen Xiao, Koushi Hidaka, Alla Gustchin, Yoshiaki Kiso, Rickey Y. Yada, Alexander Wlodawer
    • Journal Title

      Biochemistry.

      Volume: 50(41) Issue: 41 Pages: 8862-8879

    • DOI

      10.1021/bi201118z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Structure-guided design and synthesis of P1' position 1-phenylcycloalkyl-amine-derived pentapeptidic BACE1 inhibitors.2011

    • Author(s)
      Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Youhei Sohma, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Issue: 17 Pages: 5238-5246

    • DOI

      10.1016/j.bmc.2011.07.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118, KAKENHI-PROJECT-23590137
  • [Journal Article] Racemization- free synthesis of cyclic peptide by use of the O-acyl isopeptide method.2010

    • Author(s)
      Taku Yoshiya, Hiroyuki Kawashima, Yuka Hasegawa, Kazuhiro Okamoto, Tooru Kimura, Youhei Sohma, Yoshiaki Kiso
    • Journal Title

      J. Peptide Science.

      Volume: 16(8) Issue: 8 Pages: 437-442

    • DOI

      10.1002/psc.1261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790118
  • [Journal Article] Click peptide : Water-soluble precursor producing monomer amyloid. peptide in situ2010

    • Author(s)
      Hirayama, Y., Taniguchi, A., Sohma, Y., Mukai, H., Kimura, T., Hayashi, Y., Matsuzaki, K., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2009 Pages: 371-372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.2010

    • Author(s)
      Harichandra D. Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Takashi Hamada, Hamdy Abdel-Rahman, Abdellah Yamani, Ayaka Nagamine, Hayato Ikari, Naoto Igawa, Koushi Hidaka, Youhei Sohma, Tooru Kimura, Yo shiaki Kiso
    • Journal Title

      Bioorg.Med. Chem.

      Volume: 18(9) Issue: 9 Pages: 3175-3186

    • DOI

      10.1016/j.bmc.2010.03.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Cryptides : receptors and signaling mechanisms for novel neutrophil-activating peptides hidden in mitochondrial proteins2010

    • Author(s)
      Mukai, H., Seki, T., Hokari, Y., Fukamizu, A., and Kiso, Y.
    • Journal Title

      Peptides

      Volume: Vol.2010 Pages: 36-37

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Crystal growth proce- dure of HIV-1 protease-inhibitor KNI-272 com-plex for neutron structural analysis at 1.9A re- solution.2010

    • Author(s)
      Noriko Shimizu, Shigeru Sugiyama, Mihoko Maruyama, Yoshinori Takahashi, Motoyasu Adachi, Taro Tamada, Koushi Hidaka, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso, Hiroaki Adachi, Kazufumi Takano, Satoshi Murakami, Tsuyoshi Inoue, Ryota Kuroki, Yusuke, Mori, Hiroyoshi Matsumura
    • Journal Title

      Crystal Growth Design

      Volume: 10 Issue: 6 Pages: 2990-2994

    • DOI

      10.1002/psc.1239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against2010

    • Author(s)
      Taeko Kakizawa, Koushi Hidaka, Daisuke Hamada, Ryoji Yamaguchi, Tsuyoshi Uemura, Hitomi Kitamura, Harichandra D. Tagad, Takashi Hamada, Zyta Ziora, Yoshio Hamada, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      BACE1. J. Peptide Science

      Volume: 16 Issue: 6 Pages: 257-262

    • DOI

      10.1002/psc.1238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-22790119
  • [Journal Article] Reversible modification of peptides containing the O-acyl iso-prolyl- seryl motif.2010

    • Author(s)
      Michael Beiswenger, Taku Yoshiya, Yoshiaki Kiso, Chiara Cabrele
    • Journal Title

      J. Peptide Science

      Volume: 16 Pages: 303-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Investigation of A. 1. 42 mutants based on O-acyl isopeptide method ; Synthesis of O-acyl isopeptides and in situ production of their native forms2010

    • Author(s)
      Wang, H., Kakizawa, T., Taniguchi, A., Mizuguchi, T., Sohma, Y., Mukai, H., Kimura, T., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2009 Pages: 367-368

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] How much binding affinity can be gained by filling a cavity?2010

    • Author(s)
      Yuko Kawasaki, Eduardo E. Chufan, Virginie Lafont, Koushi Hidaka, Yoshiaki Kiso, L. Mario Amzel, Ernesto Freire
    • Journal Title

      Chem.Biol. Drug Design

      Volume: 75(2) Issue: 2 Pages: 143-151

    • DOI

      10.1111/j.1747-0285.2009.00921.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Characterization of receptors and signaling mechanisms for mitocryptide-2, a novel cryptide that activates neutrophils2010

    • Author(s)
      Mukai, H., Seki, T., Hokari, Y., Fukamizu, A., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2009 Pages: 97-98

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Crystal structures of the inhibitor com- plexes of human T cell leukemia virus (HTLV-1) protease.2010

    • Author(s)
      Tadashi Satoh, Mi Li, Jeffrey-Tri Nguyen, Yo shiaki Kiso, Alla Gustchina, Alexander Wlo- dawer
    • Journal Title

      J. Mol. Biol.

      Volume: 401 Issue: 4 Pages: 626-641

    • DOI

      10.1016/j.jmb.2010.06.052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Quantitative proteolytic^<18> O-labeling analysis of protein disulfide bond rearrangement2010

    • Author(s)
      Kazuki Saito, Itsuki Yasuo, HiromasaUchimura, Shizuyo Koide-Yoshida, TakaakiMizuguchi, Yoshiaki Kiso
    • Journal Title

      Pept. Sci. 2009

      Pages: 393-394

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Verification of protein disulfide bond arrangement by in-geltryptic digestion under entirely neutral pHconditions2010

    • Author(s)
      Kazuki Saito, Itsuki Yasuo, HiromasaUchimura, Shizuyo Koide-Yoshida, TakaakiMizuguchi, Yoshiaki Kiso
    • Journal Title

      Proteomics

      Volume: 10 Pages: 1505-1509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Improvement of both plasmepsin inhibitory activity and Antimalarial activity by 2-aminoethylamino substitution.2010

    • Author(s)
      Takuya Miura, Koushi Hidaka, Tsuyoshi Uemura, Keisuke Kashimoto, Yuto Hori, Yuko Kawasaki, Adam J. Ruben, Ernesto Freire, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 20(16) Issue: 16 Pages: 4836-4839

    • DOI

      10.1016/j.bmcl.2010.06.099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Cryptides : Discovery of functional cryptic peptides hidden in protein structures and identification of their signaling mechanisms2010

    • Author(s)
      Mukai, H., Seki, T., Munekata, E., and Kiso, Y.
    • Journal Title

      Peptides

      Volume: Vol.2009 Pages: 203-204

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] クリプタイドの発見と新しい生体情報伝達機構2010

    • Author(s)
      向井秀仁、木曽良明、若松馨
    • Journal Title

      生化学

      Volume: Vol.82 Pages: 524-532

    • NAID

      10026900043

    • URL

      http://wwwsoc.nii.ac.jp/jbiochem/magazine/82-06-09.pdf

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Click peptide "based on" O-acyl isopeptide method": In situ production of monomer amyloid. Peptide from water-soluble precursor analogue2010

    • Author(s)
      Taniguchi, A., Sohma, Y., Skwarczynski, M., Hirayama, Y., Okada, T., Ikeda, K., Prakash, H., Mukai, H., Kimura, T., Hayashi, Y., Hirota, S., Matsuzaki, K., and Kiso, Y.
    • Journal Title

      Peptides

      Volume: Vol.2009 Pages: 195-196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Recent progress in the drug discovery of non-peptidic BACE1 inhibitors2009

    • Author(s)
      Y. Hamada, Y. Kiso
    • Journal Title

      Expert Opinion on Drug Discovery 4

      Pages: 391-416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Small-sized HIV-1 protease inhibitors containing allo- phenylnorstatine to explore S2' pocket.2009

    • Author(s)
      Koushi Hidaka, Tooru Kimura, Hamdy M. Abdel-Rahman, Jeffrey-Tri Nguyen, Keith F. McDaniel, William E. Kohlbrenner, Akhteru- zzaman Molla, Motoyasu Adachi, Taro Tamada, Ryota Kuroki, Noriko Katsuki, Yoshiaki Tanaka, Hikaru Matsumoto, Jun Wang, Yoshio Hayashi, Dale J. Kempf, Yoshiaki Kiso
    • Journal Title

      J. Med. Chem.

      Volume: 52(23) Issue: 23 Pages: 7604-7617

    • DOI

      10.1021/jm9005115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Crystal structure of the histo-aspartic protease (HAP) from Plasmodium falciparum2009

    • Author(s)
      P. Bhaumik, H. Xiao, C. L. Parr, Y. Kiso, A. Gustchina, R. Y. Yada, A. Wlodawer
    • Journal Title

      J. Mol. Biol 388(3)

      Pages: 520-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts2009

    • Author(s)
      M. Ebina, E. Futai, C. Tanabe, N. Sasagawa, Y. Kiso, S. Ishiura
    • Journal Title

      J. Neurosci. Res 87(2)

      Pages: 360-360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Design and synthesis of inhibitory peptides against EGF receptor dimerization2009

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, ShigeyukiYokoyama, Yoshiaki Kiso, Kazuki Saito
    • Journal Title

      Pept. Sci. 2008

      Pages: 383-384

    • NAID

      10027166564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Mito- cryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils.2009

    • Author(s)
      Hidehito Mukai, Tetsuo Seki, Hiroko Nakano, Yoshinori Hokari, Toshifumi Takao, Masanori Kawanami, Hiroyuki Tsukagoshi, Hirokazu Kimura, Yoshiaki Kiso, Yasutsugu Shimonishi, Yoshisuke Nishi, Eisuke Munekata
    • Journal Title

      J. Immunology

      Volume: 182(8) Issue: 8 Pages: 5072-5080

    • DOI

      10.4049/jimmunol.0802965

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-21603014
  • [Journal Article] Cryptide signal : a novel signaling mechanisms involving cryptides2009

    • Author(s)
      Mukai, H., Ueki, N., Wakamatsu, K., and Kiso, Y.
    • Journal Title

      Peptides

      Volume: Vol.2008 Pages: 570-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] High-throughput screening method for ligand peptides using capillary electrophoresis-mass spectrometry(CE-MS)2009

    • Author(s)
      Kazuki Saito, Mamiko Nakato, TakaakiMizuguchi, Hiromasa Uchimura, ShigeyukiYokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Journal Title

      Pept. Sci. 2008

      Pages: 119-120

    • NAID

      10027166058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Crystal structure of the histo-aspartic protease from Plasmodium falciparum.2009

    • Author(s)
      Prasenjit Bhaumik, Huogen Xiao, Charity L. Parr, Yoshiaki Kiso, Alla Gustchina, Rickey Y. Yada, Alexander Wlodawer
    • Journal Title

      J. Mol. Biol.

      Volume: 388 Issue: 3 Pages: 520-540

    • DOI

      10.1016/j.jmb.2009.03.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] "Click peptide" : pH-triggered in situ production and aggregation of monomer As1-422009

    • Author(s)
      A. Taniguchi, Y. Sohma, Y. Hirayama, H. Mukai, T. Kimura, Y. Hayashi, K. Matsuzaki, Y. Kiso
    • Journal Title

      Chem Bio Chem 10(4)

      Pages: 710-715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold.2009

    • Author(s)
      Yoshio Hamada, Hiroko Ohta, Naoko Miyamoto, Diganta Sarma, Takashi Hamada, Tomoya Nakanishi, Moe Yamasaki, Abdellah Yamani, Shoichi Ishiura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 19(9) Issue: 9 Pages: 2435-2439

    • DOI

      10.1016/j.bmcl.2009.03.049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Click peptide by use of the O-acyl isopeptide method : production of amyloid. peptide from water-soluble analogue2009

    • Author(s)
      Taniguchi, A., Sohma, Y., Skwarczynski, M., Okada, T., Ikeda, K., Prakash, H., Mukai, H., Kimura, T., Hayashi, Y., Hirota, S., Matsuzaki, K., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2008 Pages: 121-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Cryptide signaling and exocytotic mechanisms induced by amphiphilic peptides2009

    • Author(s)
      Mukai, H., Ueki, N., Someya, K., Kawanami, M., Matsuo, Y., Kiyama, M., Kamijo, R., Kikichi, M., Fukuhara, S., Munekata, E., and Kiso, Y.
    • Journal Title

      Peptide Science

      Volume: Vol.2008 Pages: 307-310

    • NAID

      10027166410

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Recent progress in the drug discovery of non-peptidic BACE1 inhibitors2009

    • Author(s)
      Yoshio Hamada, Yoshiaki Kiso
    • Journal Title

      Expert Opinion on Drug Discovery

      Volume: 4(4) Issue: 4 Pages: 391-416

    • DOI

      10.1517/17460440902806377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold2009

    • Author(s)
      Y. Hamada, H. Ohta, N. Miyamoto, D. Sarma, T. Hamada, T. Nakanishi, M. Yamasaki, A. Yamani, S. Ishiura, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 19(9)

      Pages: 2435-2439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Synthesis of amyloid SS peptide1-42 (E22〓) click peptide: pH-triggered in situ production of its native form.2009

    • Author(s)
      Hui Wang, Taeko Kakizawa, Atsuhiko Taniguchi, Takaaki Mizuguchi, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 17 (14) Issue: 14 Pages: 4881-4887

    • DOI

      10.1016/j.bmc.2009.06.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Click peptide : pH-triggered in situ production and aggregation of monomer A. 1-422009

    • Author(s)
      Taniguchi, A., Sohma, Y., Hirayama, Y., Mukai, H., Kimura, T., Hayashi, Y., Matsuzaki, K., and Kiso, Y.
    • Journal Title

      Chem Bio Chem

      Volume: Vol.10 Issue: 4 Pages: 710-715

    • DOI

      10.1002/cbic.200800765

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3Cl^<pro> inhibitors2009

    • Author(s)
      T. Regnier, D. Sarma, K. Hidaka, U. Bacha, E. Freire, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 19(10)

      Pages: 2722-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] efficient synthesis of isopeptide segment and application to racemization-free segment condensation.2009

    • Author(s)
      Taku Yoshiya, Hiroyuki Kawashima, YouheiSohma, Tooru Kimura, Yoshiaki Kiso: O-Acylisopeptide method
    • Journal Title

      Org. Biomol. Chem.

      Volume: 7(14) Issue: 14 Pages: 2894-2904

    • DOI

      10.1039/b903624e

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Journal Article] Recent progress in the drug discovery of non-peptidic BACE1 inhibitors2009

    • Author(s)
      Y. Hamada, Y. Kiso
    • Journal Title

      Expert Opinion on Drug Discovery 4(4)

      Pages: 391-416

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Inhibitory effect of a dimerization-armmimeticpeptide on EGF receptor activation2009

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, ShigeyukiYokoyama, Yoshiaki Kiso, Kazuki Saito
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 19 Pages: 3279-3282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Journal Article] Development of water-soluble click peptides by use of the O-acyl isopeptide method : In situ production of Alzheimer's amyloid2009

    • Author(s)
      Taniguchi, A., Sohma, Y., Skwarczynski, M., Nagano, T., Okada, T., Ikeda, K., Prakash, H., Mukai, H., Hayashi, Y., Kimura, T., Hirota, S., Matsuzaki, K., and Kiso, Y.
    • Journal Title

      peptide, Peptides

      Volume: Vol.2008 Pages: 32-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21603014
  • [Journal Article] Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high resolution X-ray and neutron crystallography, Proc2009

    • Author(s)
      M. Adachi, T. Ohhara, K. Kurihara, T. Tamada, E. Honjo, N. Okazaki, S. Arai, Y. Shoyama, K. Kimura, H. Matsumura, S. Sugiyama, H. Adachi, K. Takano, Y. Mori, K. Hidaka, T. Kimura, Y. Hayashi, Y. Kiso, R. Kuroki
    • Journal Title

      Natl. Acad. Sci. USA 106(12)

      Pages: 4641-4646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Structure of HIV-1 protease incomplex with potent inhibitor KNI-272 determinedby high-resolution X-ray and neutron crystallography2009

    • Author(s)
      M. Adachi, T. Kimura, Y. Kiso, 他16名
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 4641-4646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Isopeptide method : Development of S-acyl isopeptide method for the synthesis of difficult sequence-containing peptides2008

    • Author(s)
      T. Yoshiya, N. Ito, T. Kimura, Y. Kiso
    • Journal Title

      J. Peptide Sci 14(11)

      Pages: 1203-1208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] BACE1 inhibitors : Optimization by replacing the P1' residue with non-acidic moiety2008

    • Author(s)
      Y. Hamada, H. Abdel-Rahman, A. Yamani, J.-T. Nguyen, K. Hidaka, T. Kimura, Y. Hayashi, K. Saito, S. Ishiura, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 18(5)

      Pages: 1649-1653

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Novel nonpeptidic and small-sized BACE1 inhibitors2008

    • Author(s)
      Y. Hamada, H. Ohta, N. Miyamoto, R. Yamaguchi, A. Yamani, K. Hidaka, T. Kimura, K. Saito, Y. Hayashi, S. Ishiura, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 18(5)

      Pages: 1654-1658

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Design, synthesis and biophysical properties of a helical As1-42 analog : inhibition of fibrillogenesis and cytotoxicity2008

    • Author(s)
      K. Matsuzaki, T. Okada, M. Tsukuda ; K. Ikeda ; Y. Sohma ; Y. Chiyomori ; A. Taniguchi ; S. Nakamura ; N. Ito ; Y. Hayashi ; Y. Kiso
    • Journal Title

      Biochem. Biophys. Res. Commun 371(4)

      Pages: 777-780

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Locking the two ends of tetrapeptidic HTLV-1 protease inhibitors inside the enzyme2008

    • Author(s)
      M. Zhang, J.-T. Nguyen, H. Kumada, T. Kimura, M. Cheng, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem 16(14)

      Pages: 6880-6890

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Design of potent aspartic protease inhibitors to treat various diseases2008

    • Author(s)
      J.-T. Nguyen, Y. Hamada, T. Kimura, Y. Kiso
    • Journal Title

      Arch. Pharm. Chem. Life Sci 341(9)

      Pages: 523-535

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Controlled production of Alzheimer's amyloid β peptide from a photo-triggered, water-soluble precursor "click peptide"2008

    • Author(s)
      A. Taniguchi, M. Skwarczynski, Y. Sohma, T. Nagano, T. Okada, K. Ikeda, H. Prakash, H. Mukai, Y. Hayashi, T. Kimura, S. Hirota, K. Matsuzaki, Y. Kiso
    • Journal Title

      Chem Bio Chem 9(18)

      Pages: 3055-3065

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin2008

    • Author(s)
      K. Hidaka, T. Kimura, A.J. Ruben, T. Uemura, M. Kamiya, A. Kiso, T. Okamoto, Y. Tsuchiya, Y. Hayashi, E. Freire, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem 16(23)

      Pages: 10049-10060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Combination of Non-naturalD-amino acid derivatives and allophenylnorstatine-dimethylthioproline scaffold in HIV proteaseinhibitors have high efficacy in mutant HIV2008

    • Author(s)
      S. Nakatani, T. Kimura, Y. Kiso, 他10名
    • Journal Title

      J.Med.Chem. 51

      Pages: 2992-3004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Combination of non-natural D-amino acid derivatives and allophenylnorstatine-dimethyl-thioproline scaffold in HIV protease inhibitors have high efficacy in Mutant HIV2008

    • Author(s)
      S. Nakatani, K. Hidaka, E. Ami, K. Nakahara, A. Sato, J.-T. Nguyen, Y. Hamada, Y. Hori, N. Ohnishi, A. Nagai, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      J. Med. Chem 51(10)

      Pages: 2992-3004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors2008

    • Author(s)
      J-T. Nguyen, M. Zhang, H. Kumada, A. Itami, K. Nishiyama, T. Kimura, M. Cheng, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 18(1)

      Pages: 366-370

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Development of broadspectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro2008

    • Author(s)
      U. Bacha, J. Barrila, S. B. Gabelli, Y. Kiso, L. M. Amzel, E. Freire
    • Journal Title

      Chem. Biol. Drug Design 72(7)

      Pages: 34-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties2008

    • Author(s)
      M. Zhang, J. Nguyen, H. Kumada, T. Kimura, M. Cheng, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem 16(10)

      Pages: 5795-5802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] "O-Acyl isopeptide method" for peptide synthesis : synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH2007

    • Author(s)
      T. Yoshiya, A. Taniguchi, Y. Sohma, F. Fukao, S. Nakamura, N. Abe, N. Ito, M. Skwarczynski, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Org. Biomol. Chem 5(11)

      Pages: 1720-1730

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors2007

    • Author(s)
      T. Kimura, J.-T. Nguyen, H. Maegawa, K. Nishiyama, Y. Arii, Y. Matsui, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett. 17(12)

      Pages: 3276-3280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] プロテアーゼ阻害剤 : 蛋白質核酸酵素2007

    • Author(s)
      濱田芳男、木曽良明、長野哲雄、長田裕之、菊地和也、上杉志成編
    • Journal Title

      増刊号「ケミカルバイオロジー」

      Pages: 1702-1707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] アルツハイマー病はどこまで克服されたか-創薬・治療の最前線を聞く2007

    • Author(s)
      木曽良明
    • Journal Title

      平成19年版人類とバイオ-知の大競争時代をいかに勝ち抜くか-(東京テクノ・フォーラム21編)

      Pages: 381-402

    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Compensating enthalpic and entropic changes hinder binding affinity optimization2007

    • Author(s)
      V. Lafont, A. A. Armstrong, H. Ohtaka, Y. Kiso, L. M. Amzel, E. Freire
    • Journal Title

      Chemical Biology & Drug Design 69(6)

      Pages: 413-422

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties. Bioorg2007

    • Author(s)
      E. Ami, K. Nakahara, A. Sato, J.-T. Nguyen, K. Hidaka, Y. Hamada, S. Nakatani, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Med. Chem. Lett 17(15)

      Pages: 4213-4217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Development of "O-Acyl Isopeptide Method"2007

    • Author(s)
      Y. Sohma, T. Yoshiya, A. Taniguchi, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Biopolymers Peptide Science 88(2)

      Pages: 253-262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R, 3R)-3-amino-2-hydroxy-4-(phenylthio) butyric acid2007

    • Author(s)
      Z. Ziora, S. Kasai, K. Hidaka, A. Nagamine, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 17(6)

      Pages: 1629-1633

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Additional interaction of allophenylnorstatine containing tripeptidomimetics with malarial aspartic protease plasmepsin II2007

    • Author(s)
      K. Hidaka, T. Kimura, Y. Tsuchiya, M. Kamiya, A. J. Ruben, E. Freire, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 17(11)

      Pages: 3048-3052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] "O-Acyl isopeptide method" for peptide synthesis : Solvent effects in the synthesis of As1-42 isopeptide using "O-acyl isodipeptide unit"2007

    • Author(s)
      A. Taniguchi, T. Yoshiya, N. Abe, F. Fukao, Y. Sohma, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      J. Peptide Sci 13(12)

      Pages: 868-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors2006

    • Author(s)
      M. O. Sydnes, Y. Hayashi, V. K. Sharma, T. Hamda, U. Bacha, J. Barrila, E. Freire, Y. Kiso
    • Journal Title

      Tetrahedron 62(36)

      Pages: 8601-8609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Chemical biology-oriented synthesis of Alzheimer's disease-related amyloid β peptide (Aβ) analogues based on the "O-acyl isopeptide method"2006

    • Author(s)
      Y. Sohma, Y. Kiso : "Click peptide"
    • Journal Title

      Chem-Bio Chem 7(10)

      Pages: 1549-1557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Small-sized BACE1 inhibitors2006

    • Author(s)
      Zyta Ziora, Tooru Kimura, Yoshiaki Kiso
    • Journal Title

      Drugs of the Future 31(1)

      Pages: 53-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Journal Article] β-Secretase inhibitors : Modification at the P4 position and improvement of inhibitory activity in cultured cell2006

    • Author(s)
      Y. Hamada, N. Igawa, H. Ikari, Z. Ziora, J.-T. Nguyen, A. Yamani, K. Hidaka, T. Kimura, K. Saito, Y. Hayashi, M. Ebina, S. Ishiura, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 16(16)

      Pages: 4354-4359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Views onamyloid hyupothesis and secretase inhibitors fortreating Alzheimer's disease : Progress andproblems2006

    • Author(s)
      J.-T. Nguyen, A. Yamani, Y. Kiso
    • Journal Title

      Current Pharmaceutical Design 12

      Pages: 4295-4312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] アルツハイマー病の治療薬をつくる2006

    • Author(s)
      石浦章一, 木曽良明
    • Journal Title

      日経サイエンス 36(4)

      Pages: 64-69

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] The novel β-secretase inhibitor KMI-429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild-type mice2006

    • Author(s)
      Masashi Asai, Chinatsu Hattori, Nobuhisa Iwata, Takaomi C. Saido, Noboru Sasagawa, Beata Szabo, Yasuhiro Hasimoto, Kei Maruyama, Sei-ichi Tamura, Yoshiaki Kiso, Shoichi Ishiura
    • Journal Title

      J. Neurochem 96(2)

      Pages: 533-540

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Journal Article] "O-Acyl isopeptide method" : racemization- free segment condensation in solid phase peptide synthesis2006

    • Author(s)
      T. Yoshiya, Y. Sohma, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Tetrahedron Lett 47(45)

      Pages: 7905-7909

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] "Click peptide" : a novel "O-acyl isopeptide method" for peptide synthesis and chemical biology-oriented synthesis of amyloid β peptide analogues2006

    • Author(s)
      Y. Sohma, A. Taniguchi, T. Yoshiya, Y. Chiyomori, F. Fukao, S. Nakamura, M. Skwarczynski, T. Okada, K. Ikeda, Y. Hayashi, T. Kimura, S. Hirota, K. Matsuzaki, Y. Kiso
    • Journal Title

      J. Peptide Science 12(12)

      Pages: 823-828

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] 今エイズ薬研究はどうなっているか2006

    • Author(s)
      日高興士, 木曽良明
    • Journal Title

      化学 61(5)

      Pages: 25-29

    • NAID

      40007270962

    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] "Click peptide" : chemicalbiology-oriented synthesis of Alzheimer's disease-related amyloid β peptide(Aβ)analogues based on the"O-acyl isopeptide method"2006

    • Author(s)
      Y. Sohma, Y. Kiso
    • Journal Title

      ChemBioChem 7

      Pages: 1549-1557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Overcoming roadblocks in lead optimization: a thermodynamic perspective2006

    • Author(s)
      Adam J. Ruben, Yoshiaki Kiso, Ernesto Freire
    • Journal Title

      Chem. Biol. Drug. Des. 67(1)

      Pages: 2-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Journal Article] Design and synthesis of potent s-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres2006

    • Author(s)
      T. Kimura, Y. Hamada, M. Stochaj, H. Ikari, A. Nagamine, H. Abdel-Rahman, N. Igawa, K. Hidaka, J.-T. Nguyen, K. Saito, Y. Hayashi, Y. Kiso
    • Journal Title

      Bioorg. Med. Chem. Lett 16(9)

      Pages: 2380-2386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] "O-Acyl isopeptide method" for the efficient synthesis of difficult sequence-containing peptides : use of "O-acyl isodipeptide unit"2006

    • Author(s)
      Y. Sohma, A. Taniguchi, M. Skwarczynski, T. Yoshiya, F. Fukao, T. Kimura, Y. Hayashi, Y. Kiso
    • Journal Title

      Tetrahedron Lett 47(18)

      Pages: 3013-3017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer's disease : Progress and problems2006

    • Author(s)
      J. Nguyen, A. Yamani, Y. Kiso
    • Journal Title

      Current Pharm. Des 12(33)

      Pages: 4295-4312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Journal Article] Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.2004

    • Author(s)
      Aiko Kiso
    • Journal Title

      Journal of Peptide Science 10(11)

      Pages: 641-647

    • Data Source
      KAKENHI-PROJECT-15390039
  • [Journal Article] Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.2004

    • Author(s)
      Aiko Kiso
    • Journal Title

      Journal of Peptide Science 10(11)

      Pages: 641-647

    • Data Source
      KAKENHI-PROJECT-16017302
  • [Patent] βセクレターゼ阻害活性を有する新規化合物2007

    • Inventor(s)
      木曽良明
    • Industrial Property Rights Holder
      木曽良明
    • Industrial Property Number
      2007-164845
    • Filing Date
      2007-06-22
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Patent] Preparation of 3-amino-2-hydroxybutanamide deriva-tives as β-secretase inhibitors2006

    • Inventor(s)
      Yoshiaki Kisoほか
    • Industrial Property Rights Holder
      大日本住友製薬
    • Filing Date
      2006-08-31
    • Acquisition Date
      2007-03-15
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Patent] 水溶性プロドラッグ2003

    • Inventor(s)
      木曽 良明
    • Industrial Property Rights Holder
      木曽 良明
    • Filing Date
      2003-07-11
    • Acquisition Date
      2005-02-03
    • Data Source
      KAKENHI-PROJECT-16017302
  • [Patent] 水溶性プロドラッグ2003

    • Inventor(s)
      木曽 良明
    • Industrial Property Rights Holder
      木曽 良明
    • Filing Date
      2003-07-11
    • Acquisition Date
      2005-02-03
    • Data Source
      KAKENHI-PROJECT-16015304
  • [Patent] 水溶性プロドラッグ2003

    • Inventor(s)
      木曽 良明
    • Industrial Property Rights Holder
      木曽 良明
    • Filing Date
      2003-07-11
    • Acquisition Date
      2005-02-03
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Patent] βセクレターゼ阻害活性を有する新規化合物

    • Inventor(s)
      木曽良明
    • Industrial Property Rights Holder
      木曽良明
    • Industrial Property Number
      2007-164845
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] マイトクリプタイド:ミトコンドリアタンパク質配列に隠された一群の免疫調節因子2016

    • Author(s)
      向井秀仁、服部竜弥、丸谷飛之、堤光己、木曽良明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Identification of receptor molecules for mitocryptides, a novel family of neutrophil-activating peptides derived from mitochondrial proteins2016

    • Author(s)
      Marutani, T., Nakashima, K., Tsutsumi, K., Hattori, T., Nishino, K., Shimizu, T., Kiso, Y., and Mukai, H.
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Suita, Osaka
    • Year and Date
      2016-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Mitocryptides: candidate factors for neutrophil-activating peptides in mitochondrial DAMPs2016

    • Author(s)
      Hattori, T., Morikawa, H., Yamada, T., Marutani, T., Kiso, Y., and Mukai, H.
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Suita, Osaka
    • Year and Date
      2016-01-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Cryptides: endogenous bioactive peptides hidden in protein structures2016

    • Author(s)
      Mukai, H., and Kiso, Y.
    • Organizer
      The 8th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Suita, Osaka
    • Year and Date
      2016-01-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 新規好中球活性化ペプチド、mitocryptide-3に対する受容体の同定2015

    • Author(s)
      丸谷飛之、中島健太、堤光己、服部竜弥、西野弘大、清水稔弘、木曽良明、向井秀仁
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 新規好中球活性化ペプチド、マイトクリプタイド-1の構造活性相関の検討2015

    • Author(s)
      堤光己、丸谷飛之、服部竜弥、清水稔弘、木曽良明、向井秀仁
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] マイトクリプタイド-3:受容体分子の解析2015

    • Author(s)
      丸谷飛之、中島健太、堤光己、服部竜弥、西野弘大、清水稔弘、木曽良明、向井秀仁
    • Organizer
      ペプチド討論会
    • Place of Presentation
      神奈川県平塚市
    • Year and Date
      2015-11-17
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] マイトクリプタイド-1のマウス免疫細胞に対する効果2015

    • Author(s)
      服部竜弥、森川広樹、丸谷飛之、堤光己、木曽良明、向井秀仁
    • Organizer
      ペプチド討論会
    • Place of Presentation
      神奈川県平塚市
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] マイトクリプタイドが免疫細胞に及ぼす影響の解析2015

    • Author(s)
      服部竜弥、森川広樹、丸谷飛之、堤光己、西義介、木曽良明、向井秀仁
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 好中球活性化ペプチド、マイトクリプタイドに対するモノクローナル抗体の作製とそれを用いた生理機能解析2013

    • Author(s)
      服部竜弥, 荒木良太, 丸谷飛之, 荻野智史, 小池祐介, 廣岡佑一, 木曽良明, 西義介, 向井秀仁
    • Organizer
      日本生化学会第86回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Defying difficult diseases: Pro- tease inhibitors and the click peptide concept using O-acyl isopeptides.2013

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      AsiaTIDES Oligo- nucleotides and Peptides
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-02-26
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] ミトコンドリアタンパク質に由来する内因性ホルミルペプチドの生体機能解析2013

    • Author(s)
      丸谷飛之, 服部竜弥, 木曽良明, 向井秀仁
    • Organizer
      日本生化学会第86回大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] ペプチド化学を基盤とする統合創薬科学研究:難病克服をめざして2013

    • Author(s)
      木曽良明
    • Organizer
      長崎大学創薬シンポジウム「アカデミア創薬と探索医療」
    • Place of Presentation
      長崎
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Endogenous N-formylated cryptides: Investigation of their biological functions2013

    • Author(s)
      Marutani, T., Hattori, T., Koike, Y., Harada, A., Watanabe, K., Kiso, Y., and Mukai, H.
    • Organizer
      4th Asia-Pacific International Peptide Symposium / 50th Japanese Peptide Symposium
    • Place of Presentation
      Suita, Osaka
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Mitocryptides: Elucidation of their biological functions with their monoclonal antibodies2013

    • Author(s)
      Hattori, T., Araki, R., Nakashima, K., Marutani, T., Ogino, S., Koike, Y., Hirooka, Y., Miyake, N., Murata, K., Watanabe, K., Kiso, Y., Nishi, Y., and Mukai, H.
    • Organizer
      4th Asia-Pacific International Peptide Symposium / 50th Japanese Peptide Symposium
    • Place of Presentation
      Suita, Osaka
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Defying Difficult Diseases: Protease Inhibitors and the Click Peptide Concept Using O-Acyl Isopeptides.2013

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      AsiaTIDES Oligonucleotides and Peptides: Research, Technology and Product Development
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Systematic identification of neutrophil-activating cryptides utilizing multiple solid-phase peptide synthesis2013

    • Author(s)
      Mukai, H., Hattori, T., Araki, R., Nakashima, K., Marutani, T., and Kiso, Y.
    • Organizer
      4th Modern SPPS and Its Applications Symposium
    • Place of Presentation
      Kobe
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Aggregation inhibitor of amyloid-β peptide based on O-acyl isopeptide2013

    • Author(s)
      Kawashima, H., Sohma, Y., Nakanishi, T., Kitamura, H., Mukai, H., Yamashita, M., Akaji, K., and Kiso, Y.
    • Organizer
      4th Asia-Pacific International Peptide Symposium / 50th Japanese Peptide Symposium
    • Place of Presentation
      Suita, Osaka
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Identification and Structure-Activity Studies of Novel Cryptides Hidden in Mitochondrial Proteins2013

    • Author(s)
      Mukai, H., Hokari, Y., Seki, T., Fukamizu, A., and Kiso, Y.
    • Organizer
      6th International Peptide Symposium / 23rd American Peptide Symposium
    • Place of Presentation
      Big Island, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] O-Acyl Isopeptide : A New Class of Aggregation Inhibitor of Amyloid β Peptide2013

    • Author(s)
      Ohno, S., Kawashima, H., Sohma, Y., Nakanishi, T., Kitamura, H., Mukai, H., Yamashita, M., Akaji, K., and Kiso, Y.
    • Organizer
      4th Modern SPPS & Its Applications Symposium
    • Place of Presentation
      Kobe
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Design and synthesis of small BACE1 inhibitor peptides.2012

    • Author(s)
      Y. Hamada, H. T. Tagad, Y. Kiso
    • Organizer
      32nd European Peptide Symposium
    • Place of Presentation
      Athens, Greece
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Defying difficult diseases: design and synthesis of aspartic protease inhibitors and click peptides based on the O-acyl isopeptide method.2012

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      32nd European Peptide Symposium
    • Place of Presentation
      Athens, Greece
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] アロフェニルノルスタチン含有プロテアーゼ阻害剤を用いたプローブ設計。2012

    • Author(s)
      日高興士、木曽良明、渡海智子、赤路健一、津田裕子
    • Organizer
      日本ケミカルバイオロジー研究会第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Functional analysis of mito- cryptides with their monoclonal antibodies2012

    • Author(s)
      Tatsuya Hattori, Shunsuke Shirota, Takayuki Marutani, Yoshiaki Kiso, Yoshisuke Nishi, Hidehito Mukai
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      Kagoshima
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Substrate Mimetic Inhibitors of Aspartic Proteases and Click Peptides via O-N Acyl Migration.2012

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      12th Chinese International Pe- ptide Symposium
    • Place of Presentation
      Shenyang, China
    • Year and Date
      2012-07-04
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Defying difficult diseases: design and synthesis of aspartic protease in- hibitors and click peptides based on the O-acyl isopeptide method.2012

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      32nd European Peptide Symposium
    • Place of Presentation
      Athens, Greece
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Substrate Mimetic Inhibitors of Aspartic Proteases and Click Peptides via O-N Acyl Migration.2012

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      12th Chinese International Peptide Symposium
    • Place of Presentation
      Shenyang, China
    • Invited
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] 生物分子を基盤とした統合創薬科学。2012

    • Author(s)
      木曽良明
    • Organizer
      日本化学会第92春季年会「未来志向の挑戦型バイオケミカルズ」
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] BACE1阻害活性を有するペプチドの設計2011

    • Author(s)
      濱田芳男、濱田貴司、木曽良明
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      豊中市
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] a novel regulatory mechanism by functional peptides hidden in protein structure.2011

    • Author(s)
      Hidehito Mukai, Yoshiaki Kiso: Cryptides and their accumulative signaling
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] 表面プラズモン共鳴を用いた細胞表面EGFレセプターへの親和性評価2011

    • Author(s)
      水口貴章,内村浩正,木曽良明,齋藤一樹,赤路健一
    • Organizer
      第1回四大学連携研究フォーラム
    • Place of Presentation
      京都工芸繊維大学60周年記念館(京都)
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Defying difficult diseases : aspartic protease inhibitors, prodrug forms and click peptides2011

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      Seventh General Meeting of the International Proteolysis Society
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-10-19
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] タンパク質に隠された生理活性ペプチド「クリプタイド」が関わる新しい生体調節機構2011

    • Author(s)
      向井秀仁、保苅義則、関哲郎、深水昭吉、木曽良明
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Defying Difficult Diseases: Aspartic Protease Inhibitors, Prodrug Forms and Click Peptides.2011

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      7th General Meeting of International Proteolysis Society
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-10-19
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] ^<18> O標識された内部標準ペプチドを用いたジスルフィド結合形成の定量的解析2011

    • Author(s)
      齋藤一樹,内村浩正,金裕三,安尾五起,小出静代,水口貴章,片岡宏誌,木曽良明
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-09-29
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Design and SAR study of tripeptide BACE1 inhibitors2011

    • Author(s)
      Yoshio Hamada, Harichandra Tagad, Yo shiaki Kiso
    • Organizer
      48th Japanese Peptide Symposium
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Defying Difficult Diseases: Design and Synthesis of Transition-State Mimetic Protease Inhibitors.2011

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-12-02
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] 生細胞を用いたSPR測定によるEGFレセプターとリガンドとの相互作用解析2011

    • Author(s)
      水口貴章,内村浩正,片岡宏誌,赤路健一,木曽良明,齋藤一樹
    • Organizer
      BIASymposium 2011「~カイネティクス×サーモダイナミクス×構造情報~発展するBiophysical Interaction Analysis
    • Place of Presentation
      ホテルモントレグラスミア大阪(大阪)
    • Year and Date
      2011-09-20
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Intact cell-based SPR analyses of interactions between EGF and its receptor2010

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
    • Organizer
      5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] アミロイドベータペプチドの機能解明を目指したO-アシルイソペプチドの利用.2010

    • Author(s)
      相馬洋平、平山雄太、谷口敦彦、向井秀仁、木曽良明
    • Organizer
      第36回反応と合成の進歩シンポジウム-ライフサイエンスを志向した理論、反応および合成-
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Improvement of affinity capillary electrophoresis-massspectrometry(ACE-MS) for screening of inhibitory peptides against protein-proteininteractions. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Organizer
      Biological Chemistry Division "Polypharmacology for Drug Discovery"
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] アミロイドβペプチドおよびインスリンの機能解明を目指したエステル含有ペプチドの利用.2010

    • Author(s)
      相馬洋平、谷口敦彦、向井秀仁、StephenKent、木曽良明
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Peptidomimetic chemistry: design of protease inhibitors, prodrug forms and click peptides.2010

    • Author(s)
      Y. Kiso
    • Organizer
      12th Napes Workshop on Bioactive Peptides / 2nd Italy-Korea Symposium on Antimicrobial Peptides
    • Place of Presentation
      Napoli, Italy
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] "クリックペプチド":水溶性プレカーサーによるアルツハイマー病関連Aβ変異体の産生.2010

    • Author(s)
      王惠、柿澤多惠子、谷口敦彦、水口貴章、相馬洋平、向井秀仁、木村徹、木曽良明
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Peptidomimetic chemistry : design of protease inhibitors, prodrug forms and click peptides.12th Napes Workshop on Bioactive Peptides2010

    • Author(s)
      Y. Kiso
    • Organizer
      12th Naples Workshop on Bioactive Peptides/2nd Italy-Korea Symposium on Antimicrobial Peptides
    • Place of Presentation
      ナポリ、イタリア
    • Year and Date
      2010-06-06
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Cryptides: Non-classical bioactive peptides hidden in protein structures.2010

    • Author(s)
      Hidehito Mukai, Tetsuo Seki, Yohinori Hokari, Akiyoshi Fukamizu, Yoshiaki Kiso
    • Organizer
      5th International Peptide Symposium/47th Japanese Peptide Symposium
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] タンパク質間相互作用の阻害を標的としたペプチドの高速スクリーニング法の開発2010

    • Author(s)
      齋藤一樹,中戸真巳子,水口貴章,和田真治,内村浩正,横山茂之,木曽良明
    • Organizer
      難病克服を目指した分子基盤創薬科学の開拓成果発表会
    • Place of Presentation
      京都薬科大学愛学館(京都)
    • Year and Date
      2010-03-15
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] 同位体ラベルした内部標準を用いたジスルフィド・タンパク質のリフォールディング条件の定量的検証法の確立2010

    • Author(s)
      内村浩正,金裕三,水口貴章,木曽良明,齋藤一樹
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Cryptides: receptors and signaling mechanisms for novel neutrophil-activating peptides hidden in mitochondrial proteins.2010

    • Author(s)
      H. Mukai, T. Seki, Y. Hokari, A. Fukamizu, Y. Kiso
    • Organizer
      31st European Peptides Symposium
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Screening methodology for discovery of inhibitory peptides against pathogenic proteins using aplug-plug affinity capillary electrophoresis technique2010

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Organizer
      5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Quantitative evaluation of refolding conditions of a disulfide protein using an isotopically labeled internal standard. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010

    • Author(s)
      Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
    • Organizer
      Biological Chemistry Division "Protein Alteration by Mutagenesis and Chemical Modification : Applications in Biochemistry, Drug Discovery, Diagonostics, and Nutrition"
    • Place of Presentation
      Honolulu, Hawaii, USA.
    • Year and Date
      2010-12-16
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Isotope labeling-assisted quantitative evaluation of refolding conditions of a recombinant disulfide protein2010

    • Author(s)
      Hiromasa Uchimura, Yusam Kim, Takaaki Mizuguchi, Yoshiaki Kiso, Kazuki Saito
    • Organizer
      5th International Peptide Symposium(5th IPS) in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] ロピナビル耐性株由来の変異を導入したHIVプロテアーゼ誘導体の解析.2010

    • Author(s)
      日高興士、安達基泰、黒木良太、濱田貴司、Sankara Rajesh、木村徹、木曽良明
    • Organizer
      第24回日本エイズ学会学術集会・総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] タンパク質間相互作用を標的としたペプチド性阻害薬リードの探索のための高速スクリーニング手法の開発2010

    • Author(s)
      齋藤一樹,水口貴章,中戸真巳子,内村浩正,横山茂之,木曽良明
    • Organizer
      日本ヒトプロテオーム機構第8回大会(日本プロテオーム学会2010年会)
    • Place of Presentation
      東京ベイホテル東急(浦安)
    • Year and Date
      2010-07-27
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] EGFレセプターを過剰に発現しているA431細胞とそのリガンドとの相互作用の表面プラズモン共鳴解析2010

    • Author(s)
      水口貴章,内村浩正,木曽良明,齋藤一樹
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山県桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-29
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Tripeptidic BACE1 inhibitors by confor- mational structure-based design.2010

    • Author(s)
      Yoshio Hamada, Harichandra Tagad, Takashi Hamada, Tooru Kimura, Yoshiaki Kiso
    • Organizer
      5th Inter- national Peptide Symposium/ 47th Japanese Peptide Symposium
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] EGFレセプターを過剰発現した細胞そのものをアナライトとしたリガンドEGFとのSPR相互作用解析2010

    • Author(s)
      水口貴章,内村浩正,木曽良明,齋藤一樹
    • Organizer
      BIASymposium 2010「アフィニティーのその先へ~Biophysical Interaction Analysis~」
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Versatile screening method for inhibitory peptide leads against protein-protein interactions2010

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Hiromasa Uchimura, Shigeyuki Yokoyama, Yoshiaki Kiso
    • Organizer
      The 13th Akabori Conference : German-Japanese Symposium on Peptide Science
    • Place of Presentation
      Breitenfelder Hof, Leipzig, Germany
    • Year and Date
      2010-09-14
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] EGFレセプター細胞外領域の二量化阻害に着目した新規ペプチド性抗がん薬リードの開発2010

    • Author(s)
      水口貴章,内村浩正,柿澤多惠子,木村徹,横山茂之,木曽良明,齋藤一樹
    • Organizer
      難病克服を目指した分子基盤創薬科学の開拓成果発表会
    • Place of Presentation
      京都薬科大学愛学館(京都)
    • Year and Date
      2010-03-15
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] 新規抗マラリア治療薬を目指したプラスメプシン阻害剤研究:酵素ポケット外での新たな相互作用.2010

    • Author(s)
      三浦拓也、日高興士、上村剛史、柏本啓介、Ernesto Freire、木村徹、木曽良明
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Application of surface plasmon resonance measurements to intact A431 cells for analysis of the interaction between EGF receptor and itsligands. 2010 International Chemical Congress of Pacific Basin Societies(PACIFICHEM 2010)2010

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Yoshiaki Kiso, Kazuki Saito
    • Organizer
      Biological Chemistry Division "Protein, Peptide, and Peptidomimetics Design"
    • Place of Presentation
      Honolulu, Hawaii, USA.
    • Year and Date
      2010-12-19
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] ロピナビル耐性株由来のHIVプロテアーゼ変異体とアロフェニルノルスタチン阻害剤の相互作用解析.2010

    • Author(s)
      日高興士、安達基泰、黒木良太、濱田貴司、Rajesh Narayanan、木村徹、木曽良明
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] In situ production of Alzheimer's Aβ mutants from water-soluble click peptide precursors.2010

    • Author(s)
      Hui Wang, Taeko Kakizawa, Atsuhiko Taniguchi, Takaaki Mizuguchi, Youhei Sohma, Hidehito Mukai, Tooru Kimura, Yoshiaki Kiso
    • Organizer
      11th Chinese International Peptide Symposium
    • Place of Presentation
      Lanzhou, China
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Characterization of signaling mechanisms for mitocryptides, novel neutorphil-activating cryptides isolated from porcine heart.2009

    • Author(s)
      Tetsuo Seki, Yoshinori Hokari, Akiyoshi Fukamizu, Yoshiaki Kiso, Hidehito Mukai
    • Organizer
      The 32nd Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] In situ production of Alzheimer's disease-related amyloid s peptide from water- soluble precursor analogs.2009

    • Author(s)
      Atsuhiko Taniguchi, Youhei Sohma, Mariusz Skwarczynski, Yuta Hirayama, Takuma Okada, Keisuke Ikeda, Halan Prakash, Hidehito Mukai, Tooru Kimura, Yoshio Hayashi, Shun Hirota, Katsumi Matsuzaki, Yoshiaki Kiso: Click peptide
    • Organizer
      238th American Chemical Society National Meeting
    • Place of Presentation
      Washington DC, USA
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] discovery of functional cryptic peptides hidden in protein structures and identification of their signaling mechanisms2009

    • Author(s)
      H. Mukai, T. Seki, E. Munekata, Y. Kiso: Cryptides
    • Organizer
      21st American Peptide Symposium
    • Place of Presentation
      Bloomington, USA
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Defying difficult diseases : design and synthesis of protease inhibitors, prodrug forms and click peptides. PSJ-AAPS Joint Symposium : New Trends of Medicinal Chemistry2009

    • Author(s)
      Y. Kiso
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] 非ペプチド型BACE1阻害剤の設計と構造活性相関.2009

    • Author(s)
      濱田芳男、大田博子、Diganta Sarma、中西智哉、Abdellah Yamani、山口亮司、日高興士、木村徹、石浦章一、木曽良明
    • Organizer
      第14回日本病態プロテアーゼ学会
    • Place of Presentation
      吹田
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] Significance of wild-type APP sequence in developing the BACE1 inhibitors.2009

    • Author(s)
      Yoshio Hamada, Daisuke Shuto, Ping Liu, Takashi Hamada, Koushi Hidaka, Tooru Kimura, Yoshiaki Kiso
    • Organizer
      46th Japanese Peptide Symposium
    • Place of Presentation
      Kitakyushu, Japan
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] An efficient peptide screening method using capillary electrophoresis-mass spectrometry2009

    • Author(s)
      Kazuki Saito, Mamiko Nakato, Takaaki Mizuguchi, Shinji Wada, Hiromasa Uchimura, Shigeyuki Yokoyama, Hiroshi Hirota, Yoshiaki Kiso
    • Organizer
      3rd Asia-Pacific International Peptide Symposium(3rd APIPS)
    • Place of Presentation
      ShinevilleLuxury Resort, Jeju, Korea
    • Year and Date
      2009-11-10
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Defying difficult diseases:Peptidomimetic protease inhibitors, prodrug forms and click peptides.2009

    • Author(s)
      Yoshiaki Kiso
    • Organizer
      3rd Asia-Pacific International Peptide Symposium/ 13th Korean Peptide & Protein Symposium
    • Place of Presentation
      Jeju Island, Korea
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] プラスメプシンを標的とした新規抗マラリア治療薬の開発:酵素ポケット外へのアミノ置換基の伸長.2009

    • Author(s)
      三浦拓也、日高興士、上村剛史、柏本啓介、木村徹、木曽良明、Ernesto Freire
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] HIV protease inhibitor design to employ water molecules.2009

    • Author(s)
      K. Hidaka, T. Hamada, M. Adachi, R. Kuroki, T. Kimura, Y. Kiso
    • Organizer
      Sixth General Meeting of the International Proteo- lysis Society
    • Place of Presentation
      Gold Coast, Australia
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] An inhibitory cyclic peptide against EGF receptor dimerization2009

    • Author(s)
      Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, Shigeyuki Yokoyama, Yoshiaki Kiso, Kazuki Saito
    • Organizer
      3rd Asia-Pacific International Peptide Symposium(3rdAPIPS)
    • Place of Presentation
      Shineville Luxury Resort, Jeju, Korea
    • Year and Date
      2009-11-08
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] 架橋水および水和を利用するHIVプロテアーゼ阻害剤研究.2009

    • Author(s)
      日高興士、Jeffrey-TriNguyen、濱田貴司、安達基泰、黒木良太、木村徹、木曽良明
    • Organizer
      第23回日本エイズ学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21249007
  • [Presentation] EGFレセプターの二量化阻害に着目した新規抗がん薬リードの設計2009

    • Author(s)
      水口貴章,内村浩正,柿澤多惠子,木村徹,横山茂之,木曽良明,齋藤一樹
    • Organizer
      第59回日本薬学会近畿支部総会・大会
    • Place of Presentation
      近畿大学(東大阪)
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590129
  • [Presentation] Synthesis of transition-state mimic protease inhibitors and click peptides based on O-N acyl shift2008

    • Author(s)
      Y. Kiso
    • Organizer
      10th Chinese International Peptide Symposium(CPS-2008)
    • Place of Presentation
      Xi'an, China
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] SAR study of BACE1 inhibitors containing pyridine derivatives2008

    • Author(s)
      H. Ohta, Y. Hamada, N. Miyamoto, R. Yamaguchi, A. Yamani, K. Hidaka, T. Kimura, K. Saito, S. Ishiura, Y. Kiso
    • Organizer
      45th Japanese Peptide Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Defying difficult diseases : peptide chemistry in medicinal science2008

    • Author(s)
      Y. Kiso
    • Organizer
      45th Japanese Peptide Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] 難病克服を目指した生物分子を基盤とする創薬科学2008

    • Author(s)
      木曽良明
    • Organizer
      第1回熊本創薬シンポジウム
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Effect of dipeptidomimetics on malaria parasite proliferation inhibition targeting plasmepsin2008

    • Author(s)
      K. Hidaka, T. Kimura, T. Uemura, A. J. Ruben, E. Freire, Y. Kiso
    • Organizer
      45th Japanese Peptide Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] BACE1阻害剤の設計-ペプチドから非ペプチドへ2008

    • Author(s)
      濱田芳男、大田博子、宮本奈緒子、山口亮司、A. Yamani、日高興士、木村徹、齋藤一樹、石浦章一、木曽良明
    • Organizer
      第13回病態と治療におけるプロテアーゼとインヒビター学会
    • Place of Presentation
      吹田
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] β-セクレターゼをターゲットとするアミロイド生成阻害薬開発の展望2008

    • Author(s)
      木曽良明
    • Organizer
      日本薬学会第128年会シンポジウム「アルツハイマー病の画期的創薬」
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] 生物分子システムを基盤とする創薬科学2008

    • Author(s)
      木曽良明
    • Organizer
      統合創薬科学フロンティアシンポジウム~伝承薬から生物分子システムまでを基盤として~
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Challenging difficult diseases : protease inhibitors and prodrug forms2007

    • Author(s)
      Y. Kiso
    • Organizer
      2nd European Conference on Chemistry for Life Sciences
    • Place of Presentation
      Wroclaw, Poland
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Non-peptidic small-sized BACE1 inhibitors : optimazation based on the docked inhibitor's conformer in BACE12007

    • Author(s)
      Y. Hamada, N. Miyamoto, R. Yamaguchi, A. Yamani, K. Hidaka, H. Kumada, T. Kimura, K. Saito, Y. Hayashi, S. Ishiura, Y. Kiso
    • Organizer
      20th American Peptide Symposium : Peptides for Youth
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] HIV protease and malarial plasmepsin inhi bitors with hydroxylmethylcarbonyl isostere2007

    • Author(s)
      K. Hidaka, T. Kimura, Y. Tsuchiya, M. Kamiya, E. Freire, B. M. Dunn, Y. Hayashi, Y. Kiso
    • Organizer
      5th General Meeting of the International Proteolysis Society
    • Place of Presentation
      Patras, Greece
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Defying difficult diseases : Synthesisof peptidomimetic protease inhibitors, prodrugforms and click peptides2007

    • Author(s)
      Y. Kiso
    • Organizer
      Modern Solid Phase Peptide Synthesis &amp; Its Applications
    • Place of Presentation
      Port Douglas, Australia
    • Year and Date
      2007-10-17
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Click peptide : pHor photo-triggered in situ production of Alzheimer's disease-related amyloid β peptide 1-42. 4th Takeda Sci. Found. Symp. PharmaSciences2007

    • Author(s)
      A. Taniguchi, Y. Sohma, Y. Hayashi, S. Hirota, K. Matsuzaki, Y. Kiso
    • Organizer
      On the Frontiers of Chem. Biol
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Defying difficult diseases : peptidomimetic protease inhibitors, prodrug forms and click peptides2007

    • Author(s)
      Y. Kiso
    • Organizer
      First Indian Peptide Symposium
    • Place of Presentation
      Hyderabad, India
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Challenging difficult diseases:protease inhibitors and prodrug forms2007

    • Author(s)
      Y.Kiso
    • Organizer
      2nd European Conference on Chemistry for Life Sciences
    • Place of Presentation
      Wroclaw,Poland
    • Year and Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Defying difficult diseases : Synthesis of peptidomimetic protease inhibitors, prodrug forms and click peptides2007

    • Author(s)
      Y. Kiso
    • Organizer
      Modern Solid Phase Peptide Synthesis & Its Applications
    • Place of Presentation
      Port Douglas, Australia
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Challenging difficult diseases : synthesis of protease inhibitors and click peptides2007

    • Author(s)
      Y. Kiso
    • Organizer
      The 6th International Symposium on Frontiers in Protein Chemistry and Biotechnology (ISFPCB'07)
    • Place of Presentation
      Changchun, China
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Challenging intractable diseases : protease inhibitors and O-N acyl migration-type prodrug forms2006

    • Author(s)
      Y. Kiso
    • Organizer
      9th Chinese International Peptide Symposium (CPS-9)-New Age of Peptide Biology and Chemistry
    • Place of Presentation
      Shanghai, China
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Defying difficult diseases : design of protease inhibitors and prodrug forms2006

    • Author(s)
      Y. Kiso
    • Organizer
      ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Application of intramolecular migration reaction in peptide chemistry to chemical biology based on "click peptide", and chemical pharmaceutics2006

    • Author(s)
      Y. Hayashi, Y. Sohma, A. Taniguchi, M. Skwarczynski, T. Kimura, Y. Kiso
    • Organizer
      The 11th Akabori Conf. 2006Japanese-German Symp. Peptide Sci
    • Place of Presentation
      Kloster Banz, Germany
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Substrate transition-state mimetic inhibitors and prodrug forms using O-N intramolecular acyl migration2006

    • Author(s)
      Y. Kiso
    • Organizer
      7th Tetrahedron Symposium. Challenges in Organic Chemistry
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Challenging difficult diseases : peptide mimetic inhibitors and click peptides2006

    • Author(s)
      Y. Kiso
    • Organizer
      10th Korean Peptide Symposium Frontiers in Peptide Science
    • Place of Presentation
      Korea,Seoul
    • Year and Date
      2006-11-12
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Novel thio-derivative of phenylnorstatine and its application to the BACE1 inhibitors design2006

    • Author(s)
      Z. Ziora, S. Kasai, K. Hidaka, A. Nagamine, T. Kimura, Y. Hayashi, Y. Kiso
    • Organizer
      29th European Peptide Symposium
    • Place of Presentation
      Gdansk, Poland
    • Data Source
      KAKENHI-PROJECT-18209005
  • [Presentation] Adaptive space search : Design of peptidomimetic inhibitors and prodrugs of aspartic proteases targeting intractable diseases.2005

    • Author(s)
      Y Kiso
    • Organizer
      2005 International Chemical Congress of Pacific Basin Societies(Pacifichem 2005)
    • Place of Presentation
      Honolulu, U.S.A.
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Presentation] Adaptive space search:Design of peptidomimetic inhibitors and prodrugs of aspartic proteases targeting intractable diseases2005

    • Author(s)
      Y. Kiso
    • Organizer
      2005 International Chemical Congress of Pacific Basin Societies(Pacifichem 2005)
    • Place of Presentation
      Honolulu,U.S.A.
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390039
  • [Presentation] 新規の内因性ホルミルペプチドによる好中球活性化機序

    • Author(s)
      丸谷飛之、堤光己、服部竜弥、小池裕介、原田明彦、渡辺建佑、野口公輔、山中陽介、木曽良明、向井秀仁
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 好中球活性化ペプチド、マイトクリプタイド-1に対する中和抗体の取得とそれを用いた生理機能解析

    • Author(s)
      服部竜弥、荒木良太、福井茜音、中島健太、丸谷飛之、木曽良明、西義介、向井秀仁
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 一群の新規好中球活性化ペプチド、マイトクリプタイドに対する特異的抗体を用いた生体機能解析

    • Author(s)
      服部竜弥、荒木良太、渡辺建佑、丸谷飛之、中島健太、西義介、木曽良明、向井秀仁
    • Organizer
      日本ケミカルバイオロジー学会 第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Functional analysis of mitocryptides with their neutralizing monoclonal antibodies

    • Author(s)
      Hattori, T., Araki, R., Watanabe, K., Marutani, T., Nakashima, K., Nishi, Y., Kiso, Y., and Mukai, H.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      Sofia, Bulgaria
    • Year and Date
      2014-08-31 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Mitocryptides: Physiological Significance of a Novel Family of Neutrophil-Activating Peptides

    • Author(s)
      Mukai, H., Hattori, T., Marutani, T., Nakashima, K., Tsutsumi, K., and Kiso, Y.
    • Organizer
      15th German-Japanese Symposium on Peptide Science
    • Place of Presentation
      Boppard, Germany
    • Year and Date
      2014-09-07 – 2014-09-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] ミトコンドリアタンパク質に由来する内因性N-ホルミル化クリプタイドの生体機能解析

    • Author(s)
      丸谷飛之、服部竜弥、小池祐介、原田明彦、渡辺建佑、堤光己、野口公輔、木曽良明、向井秀仁
    • Organizer
      日本ケミカルバイオロジー学会第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] マイトクリプタイド-1受容体のリガンド認識機構の検討

    • Author(s)
      堤光己、丸谷飛之、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] 一群の新規好中球活性化ペプチド、マイトクリプタイドに対する受容体のリガンド認識機構の解明

    • Author(s)
      中島健太、丸谷飛之、服部竜弥、青木慎一郎、梅田龍平、仁本義章、野口公輔、福井茜音、山中陽介、木曽良明、向井秀仁
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] マイトクリプタイド-3の好中球様細胞活性化における構造活性相関の検討

    • Author(s)
      中島健太、丸谷飛之、服部竜弥、野口公輔、木曽良明、向井秀仁
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25350971
  • [Presentation] Mitocryptide-2: structure-activity relationships for the elucidation of ligand recognition mechanisms of Formyl-peptide receptor like-1

    • Author(s)
      Marutani, T., Hattori, T., Koike, Y., Harada, A., Watanabe, K., Kiso, Y., and Mukai, H.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      Sofia, Bulgaria
    • Year and Date
      2014-08-31 – 2014-09-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25350971
  • 1.  KIMURA Tooru (70204980)
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    # of Collaborated Products: 59 results
  • 2.  AKAJI Kenichi (60142296)
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  • 12.  霜倉 正徳 (10171000)
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  • 13.  YARCHOAN Robert
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  MITSUYA Hiroaki
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  SOHMA Youhei (10565518)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 15 results
  • 16.  SAITO Kazuki (10192585)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TAKADA Kanji (30102106)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NOZAKI Tomoyoshi (60198588)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  ALI Vahab (20400757)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TAKAHASHI Yasuhiro (10154874)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  野元 裕 (80164747)
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    # of Collaborated Products: 0 results
  • 22.  松田 彰 (90157313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  柴崎 正勝 (30112767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  影近 弘之 (20177348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  佐々木 琢磨 (90109976)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  宗像 英輔 (60072766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  藤井 信孝 (60109014)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  大野 素徳 (30038434)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  下西 康嗣 (00029951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  井上 謙一郎 (40025713)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  片岡 貞 (00082975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  MIZUGUCHI Takaaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 30 results
  • 33.  ROBERT Yarch
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  USSERY Micha
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  TORCHIA Denn
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  三本 勤
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  川島 浩之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 38.  斎藤 一樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 30 results

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