HARIGAYA Kenichi 張ヶ谷健一

… Alternative Names

張ケ谷健一ハリガヤケンイチ

張ヶ谷健一ハリガヤケンイチ

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Researcher Number	40101894
Affiliation (based on the past Project Information) *help	2010 – 2012: 千葉大学, 大学院・医学研究院, 教授 2007: Chiba University, Graduate School of Medicine, Department of Molecular and Tumor Pathology, Professor 2006: 千葉大学, 大学院医学研究院, 教授 2001 – 2005: 千葉大学, 大学院・医学研究院, 教授 2000: Chiba University, School of Medicine Professor, 医学部, 教授 … More 1998: CHIBA UNIVERSITY,SCHOOL OF MESICINE.Proffesor, 医学部, 教授 1995 – 1997: 千葉大学, 医学部, 助教授 1988 – 1993: 千葉大学, 医学部, 助教授 1986: School of Medicine, Keio University, 医学部, 助手 1986: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Biological Sciences / Human pathology Except Principal Investigator Biological Sciences / General medical chemistry / Molecular biology / Human pathology
Keywords	Principal Investigator CD44 / hMena / RanBPM / NFkB / CD44 knockout mice / cell motility / yeast-two hybrid / CD44E / VEGF / PCR … More / 腫瘍プログレッション / ヒト骨髄間質細胞株 / 細胞膜接着分子 / 蛋白質 / 生体分子 / 癌 / 遺伝子 / 浸潤 / 腫瘍 / 細胞間相互作用 / IL-11 / 接着分子 / ストロ-マ造血 / adhesion related molecule (s) / Monoclonal antibodies / Hematopoietic stem cells / Marrow stromal cell line / 造血細胞増殖分化 / 骨髄間質細胞株 / 細胞接着分子 / モノクロナ-ル抗体 / ヒト骨髄ストロ-マ細胞株 / Cell to cell interaction / Hematopoietic factor Hematopoietic stem cells / Recombinant plasmid / Bone marrow stromal cell line / 増殖因子 / 造血幹細胞 / アミノ酸分析 / ヒト骨髄支持細胞株 / コロニー刺激因子 / リン酸カルシウム法 / pSV3gpt / RhoA / CD44シグナリング / Toll-like receptor / TUMOR PROGRESSION / MICROVESSEL FORMATION / TUMOR METASTASIS / TUMOR INVASION / TUMOR NECROSIS / バリアント / 転移 / 腫瘍のプログレッション / 腫瘍浸潤転移 / 腫瘍血管増生 / 腫瘍転移 / 腫瘍浸潤 / 腫瘍壊死 / Tumor progression / Follicular lymphoma / 腫瘍進展 / 濾胞性リンパ腫 / EGFR / RTK / 腫瘍浸潤・転移 / がん治療 / 癌幹細胞 / CD44核内移行 / EMT / ヒアルロン酸 / ヒアルロン酸、がん治療 / 上皮-間葉転換(EMT) / 癌浸潤・転移、CD44 / チロシンリン酸化 / FAK / Rho / マトリックスメタロプロテイアーゼ / 細胞運動 / 骨髄ストローマ細胞 / 細胞接着 / モノクロナール抗体 / β1インテグリン / 膜蛋白 / インテグリン / steel factor / 骨髄ストロ-マ細胞株 / デスモゾ-ム様細胞接着装置 / インテグリレ … More Except Principal Investigator Mastermind / Notch / EBウイルス / Fucose / 遺伝子欠失マウス / シグナル伝達 / Nucleotide sugar transporter / Signal Transduction / Glycoprotein / Delta / 糖タンパク質 / EGF / STAT / Epstein-Barr virus / 造血 / 発生・分化 / 発現制御 / Notchシグナル伝達系 / Knockout Mouse / Abnormal Sex Differentiation / Hematopoiesis / Development / Regulation of Transcription / がん / 性分化異常 / Genetic disease / Knockout mouse / Transcription factor / 遺伝性疾患 / 転写因子複合体 / Ligand-Receptor Interaction / Transcription Factor / Notch Signaling / Fringe / リガンドー受容体相互作用 / Neurotic / リガンド-受容体相互作用 / フコース / 転写因子 / 細胞内シグナル伝達 / Tumor suppressor / Tumor progression / Esophageal Cancer / Signal transduction / tumor suppressor / tumor suppresspr / 腫瘍進展 / 食道癌 / Gastric carcinoma / Hodgkin's disease / Latent membrane protein-1 / bcl-2免疫染色 / EBV関連胃癌 / EBV種地域差 / 欠失LMP-1遺伝子 / 胃癌 / ホジキン病 / LMP-1 / gastric carsinoma / Hodgkin′s disease / Latent memhranl protein-1 / バースト刺激因子 / 増殖因子のアミノ酸解析 / 白血病細胞株 / 造血幹細胞増殖因子 / 造血器腫瘍 / LCL / バーキットリンパ腫 / RBP-J / EBNA2 Less

Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membranePrincipal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
発がん促進、防御の二面性を示すNotchシグナル伝達系の調節因子群の機能
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Biochemical and Cell Biological Study for Regulators of Notch Signaling
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University
腫瘍原性ヘルペスウイルスと宿主Notchシグナル伝達系との相互作用
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Functions of Intracellular Regulators of Notch Signaling
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Chiba University
EBウイルスの発がんタンパク質EBNA2と宿主タンパク質との相互作用の研究
- Principal Investigator
  
  北川元生
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析Principal Investigator
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Molecular cloning and function of CD44 cytoplasmic domain associated moleculesPrincipal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
Study of Intracellular Regulators of Notch Signaling
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Chiba University
Molecular Analysis on Tumor Invasion and Metastasis of CD44 Variant FormsPrincipal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi, 岸宏久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Chiba University
CD44の細胞運動・転移関連遺伝子発現における役割Principal Investigator
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Physiological significance of EGF/STAT1 pathway
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Chiba University
Epstein-Barr virus latent membrane protein-1 oncogene deletions in Hodgkin's disease and gastric carcinoma in Japan and Nepal.
- Principal Investigator
  
  ISHII Genichiro, 三方淳男
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  SCHOOL OF MEDICINE, CHIBA UNIVERSITY
Study on CD44 molecule in follicular lymphomaPrincipal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
インターロイキン11の産生とその遺伝子導入マウスの作製Principal Investigator
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
造血細胞ー骨髄支持細胞株間接着分子のアミノ酸配列の決定とリガンドの同定Principal Investigator
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
造血幹細胞で骨髄支持細胞間の細胞膜接着分子の精製と機能解析Principal Investigator
- Principal Investigator
  
  張ケ谷健一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
造血幹細胞と造血支持細胞間の細胞膜接着分子の精製と機能解析Principal Investigator
- Principal Investigator
  
  張ケ谷健一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
造血幹細胞・骨髄間質細胞間細胞膜接着分子の機能解析と白血病細胞発生における役割Principal Investigator
- Principal Investigator
  
  張ヶ谷健一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Chiba University
Purification and Functional Analysis of Adfesion Related Molecules Between Hematopoietic Stem Cells and Marrow Stromal Cells.Principal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University
造血多能幹細胞増殖因子を用いた骨髄性白血病発生機序の解析
- Principal Investigator
  
  渡辺陽之輔
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Keio University
The establishment of humanmarrow stromal cell lines and their effects on the proliferation and differentiation of hematopoietic stem cells.Principal Investigator
- Principal Investigator
  
  HARIGAYA Kenichi, 張ヶ谷健一
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University

All 2013 2012 2011 2010 2008 2007 2006

All Journal Article Presentation Book

[Book] 第2部病理診断医になじみのある疾患関連分子解説編CD44(病理と臨床臨時増刊号vol.292011
- Author(s)
  豊田亮彦、斉藤光芳、張ヶ谷健一
- Publisher
  分光堂
- Data Source
  KAKENHI-PROJECT-22390074
[Book] 第2部病理診断医になじみのある疾患関連分子診断編CD44(病理と臨床臨時増刊号vol.292011
- Author(s)
  豊田亮彦、斉藤光芳、張ヶ谷健一
- Publisher
  分光堂
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Interleukin 6 mediates production of interleukin 10 in metastatic melanoma2012
- Author(s)
  Terai M, Eto M, Young GD, Berd D, Mastrangelo MJ, Tamura Y, Harigaya K, Sato T
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61 Pages: 145-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Charac- terization of sarcoma-like cells derived from endarterectomized tissues from patients with CTEPH and establishment of a mouse model of pulmonary artery intimal sarcoma2012
- Author(s)
  Jujo T, Sakao S, Kantake M, Maruoka M, Tanabe N, Kasahara Y, Kurosu K, Masuda M, Harigaya K, Tatsumi K
- Journal Title
  
  Int J Oncol
  
  Volume: 41(2) Pages: 701-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Interleukin 6 mediates production of interleukin 10 in metastatic melanoma2012
- Author(s)
  Terai M, Harigaya K
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61(2) Pages: 145-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Mastermind-like 1 (MamL1) andmastermind-like 3 (MamL3) are essential forNotch signaling in vivo2011
- Author(s)
  Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M
- Journal Title
  
  Development
  
  Volume: 138 Pages: 5235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by theHAS2-HYAL2/CD44 system on the plasma membrane2011
- Author(s)
  Saito T, Kawana H, Azuma K,Toyoda,A,Fujita H, Kitagawa M, Harigaya K
- Journal Title
  
  Int J Oncol
  
  Volume: 39(5) Pages: 1311-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane2011
- Author(s)
  Saito T, Harigaya K
- Journal Title
  
  Int J Oncol
  
  Volume: 39(5) Pages: 1311-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo2011
- Author(s)
  Oyama T, Harigaya K
- Journal Title
  
  Development
  
  Volume: 138(23) Pages: 5235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Overexpression of human ortho log of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers.2011
- Author(s)
  Toyoda A, Harigaya K
- Journal Title
  
  Int J Oncol.
  
  Volume: 38(1) Pages: 89-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers2011
- Author(s)
  Toyoda A, Yokota A, Saito T, Kawana H, Higashi M, Suzuki Y, Tanaka T, Kitagawa M, Harigaya K
- Journal Title
  
  Int J Oncol
  
  Volume: 38(1) Pages: 89-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Visualization of the Activity of Rac1Small GTPase in a Cell2010
- Author(s)
  Higashi M, Yu J, Tsuchiya H, Saito T, Oyama T, Kawana H, Kitagawa M, Tamaru J, Harigaya K
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 43(6) Pages: 163-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Visualization of the Activity of Racl Small GTPase in a Cell.2010
- Author(s)
  Higashi M, Harigaya K
- Journal Title
  
  Acta Histochem Cytochem.
  
  Volume: 43(6) Pages: 163-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells2010
- Author(s)
  Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y,Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo TA, Toyoda T, Ohara O, Harigaya K, Koseki H, Taniguchi M
- Journal Title
  
  J Clin Invest
  
  Volume: 120(7) Pages: 2610-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex2010
- Author(s)
  Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
- Journal Title
  
  Nat Cell Biol
  
  Volume: 12(3) Pages: 278-85
- NAID
  120005293254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.2010
- Author(s)
  watarai H, Harigaya K
- Journal Title
  
  J Clin Invest.
  
  Volume: 120(7) Pages: 2610-2618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells : a novel character of tumor edu Gated fibroblasts.2010
- Author(s)
  Ishii G, Harigaya K
- Journal Title
  
  Int J Oncol.
  
  Volume: 37(2) Pages: 317-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts2010
- Author(s)
  Ishii G, Hashimoto H, Asada K, Ito T, Hoshino A, Fujii S, Kojima M, Kuwata T, Harigaya K, Nagai K, Ushijima T, Ochiai A
- Journal Title
  
  Int J Oncol
  
  Volume: 37(2) Pages: 317-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390074
[Journal Article] CD44 suppresses Toll-like receptor-mediated inflammation2008
- Author(s)
  Kawana H., Karaki H., Higashi M., Miyazaki M., Hilberg F., Kitagawa M., and Harigaya K.
- Journal Title
  
  J. Immunol 180
  
  Pages: 4235-4245
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer2008
- Author(s)
  Takami Y., Higashi M., Kumagai S., Kuo P. C., Kawana H., Koda K., Miyazaki M., and Harigaya K.
- Journal Title
  
  Dig. Dis. Sci. 53
  
  Pages: 467-473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A. 104
  
  Pages: 9764-9769
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] Vasospastic angina in a 13-year-old female patient whose only symptom was toothache2007
- Author(s)
  Okajima Y., Hirai A., Higashi M., and Harigaya K.
- Journal Title
  
  Pediatr. Cardiol 28
  
  Pages: 68-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] Enhancement of chemosensitivity toward peplomycin by calpastatin -stabilized NF-kB p65 in esophageal carcinoma cells: possible involvement of Fas/Fas-L synergism2006
- Author(s)
  Liu T.-L., Shimada H., Ochiai T., Shiratori T., Lin S.-E., Kitagawa, M., Harigaya K., Maki M., Oka M., Abe T., Takiguchi M., and Hiwasa T.
- Journal Title
  
  Apoptosis 11
  
  Pages: 1025-1037
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Journal Article] An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis2006
- Author(s)
  Matsushita K, Tomonaga T., Shimada H., Shioya A., Higashi M., Matsubara H., Harigaya K., Nomura F., Libutti D., Levens D., and Ochiai T.
- Journal Title
  
  Cancer Res 66
  
  Pages: 1409-1417
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Switching of CD44 and hMena mRNA splice variants between the intramucosal lesion and invasive front of early stage human colorectal carcinoma (pT1) : and their relationship to the expression of cancer stem cell markers and clinicopathological features.2013
- Author(s)
  Hiroshi Yoshida^<1,2>, Akihiro Toyoda^<1>, Wataru Masuda^<1>, Noriyuki Tanaka^<1,2>, Motoo Kitagawa^<1>, Yoshio Suzuki^<2>, Kenichi Harigaya^<1>
- Organizer
  AACR 2013
- Place of Presentation
  Washington, DC、USA
- Year and Date
  2013-04-07
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Switching of CD44 and hMena mRNA splice variants between the intramucosal lesion and invasive front of early stage human colorectal carcinoma (pT1), and their relationship to the expression of cancer stem cell markers and clinico- pathological features2013
- Author(s)
  Yoshida H, Toyoda A, Tanaka N, Masuda W,Kitagawa M, Suzuki Y, Harigaya K
- Organizer
  Proceedings of the 104th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington, DC. Philadelphia (PA): AACR; 2013. Abstract nr 280
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] CD44-EGFR interaction regulates motility of cancer cells associates with the EMT2011
- Author(s)
  Kenichi Harigaya
- Organizer
  第20回日本癌病態治療研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] HAS2-Hyal2/CD44 system supports spontaneous random cell movement of human cancer cells in an autocrine mechanism2011
- Author(s)
  Saito T, Kawana H, Azuma K, Toyoda A, Fujita H, Kitagawa M, HarigayaK
- Organizer
  Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-01-23
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Functions of Mastermind in Notch-dependent and Notch-independent transcriptional activation2011
- Author(s)
  Motoo Kitagawa, Kenichi Harigaya
- Organizer
  第6回Notch研究会
- Place of Presentation
  千葉県野田市
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] 心筋炎の合併が考えられた新型インフルエンザ感染症の剖検例2011
- Author(s)
  小豆畑康児、張ヶ谷健一
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-30
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] ヒト大腸癌および腫瘍浸潤部におけるhMenaの発現についての解析2011
- Author(s)
  豊田亮彦、張ヶ谷健一
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-30
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] CD44 has dual functions to enhance the hyaluronan-induced chemokinesis in cancer cells as an associated molecule of hyaluronidase2-mediated HA catabolism and a hyaluronan receptor for RhoGTPase activation2011
- Author(s)
  Kenichi Harigaya
- Organizer
  AACR 102^<nd> Annual Meeting 2011
- Place of Presentation
  Orlando, Florida
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] HAS2-HYAL2/CD44が産生した低分子ヒアルロン酸はautocrine chemokinetic motility factorである2011
- Author(s)
  斉藤光芳、張ヶ谷健一
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-30
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] ヒト大腸癌および腫瘍浸潤部におけるhMenaの発現についての解析2011
- Author(s)
  豊田亮彦、張ヶ谷健一
- Organizer
  第20回日本癌病態治療研究会
- Place of Presentation
  東京
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] HAS2-HYAL2/CD44 system supports spontaneous random cell movement of human cancer cells in an anticrine mechanism.2011
- Author(s)
  Harigaya K
- Organizer
  Keystone Symposia on Molecular and Cellular Biology
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-01-23
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Fragmented hyalu- ronan is an autocrine chemokinetic motility factor supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membrane2010
- Author(s)
  Harigaya K
- Organizer
  15th World Congress on Advances in Oncology
- Place of Presentation
  Loutaraki, Greece. (Invited Speaker)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by HAS2-CD44/hyaluronidase-2system on the plasma membrane.2010
- Author(s)
  Harigaya K
- Organizer
  15^<th>world Congress on Advances on Oncology
- Place of Presentation
  Loutraki, Greece(招待講演)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] CD44 suppresses the toll-like receptor signaling.2010
- Author(s)
  Harigaya K
- Organizer
  The 8^<th> International Conference on Hyaluronan Sciences
- Place of Presentation
  Kyoto(招待講演)
- Year and Date
  2010-06-10
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] CD44 suppresses Toll-like receptor signaling2010
- Author(s)
  Harigaya K
- Organizer
  8th International Conference on Hyaluronan Science
- Place of Presentation
  Kyoto (Invited Speaker)
- Year and Date
  2010-06-10
- Data Source
  KAKENHI-PROJECT-22390074
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Matsuno K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The Notch Meeting
- Place of Presentation
  Athens, Greece
- Year and Date
  2007-09-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Morphology of transplanted tumors in mouse by Caco2 cell line2007
- Author(s)
  Umemiya T., and Harigaya K.
- Organizer
  The 16th Annual Meeting of Japanese Society of Strategies for Cancer Research and Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2007-07-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] The Notch coactivators Mastermind-1 and -2 are essential for embryonic vascular development in mice2007
- Author(s)
  Oyama T., Harigaya K., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Oyama T., Harigaya K., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 5th Stem Cell Research symposium
- Place of Presentation
  Awaji
- Year and Date
  2007-05-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Functions of a neurogenicgene, pecanex, in Notch signaling2007
- Author(s)
  Yamakawa T., Sasamura T., Oyama T., Kanai M., Kitagawa M., Harigaya K., and Matsuno K.
- Organizer
  The 30th Annual Meeting of the Molecular Biology Society of Japan, The 80th Annual Meeting of Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] A case of sclerosing hemangioma of the lung that formed disseminated lesions at the surface of pleura2007
- Author(s)
  Azuhata K., Kishi H., Hoshino H., Saito Y., Oka T., Hiroshima K., Mikata I., and Harigaya K.
- Organizer
  The 96th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Osaka
- Year and Date
  2007-03-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo2007
- Author(s)
  Kitagawa M., Oyama T., Muradil A., Hozumi K., Habu S., Oguro H., Iwama A., Sakamoto R., Sato M., Yoshida N., and Harigaya K.
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] hMena works as a negative regulator of Rac 1 GTPase at the tip of lamellipodia2006
- Author(s)
  Ishikawa C., Higashi M., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  46th Annual Meeting of American Society for Cell Biology
- Place of Presentation
  San Diego, USA
- Year and Date
  2006-12-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Induction of PDLIM2 gene expression by hypoxia and its role in cell motility and invasion of tumor cells2006
- Author(s)
  Ito S., Koshikawa N., Mochizuki S., Ohira M., Nakagawara A., Harigaya K., and Takenaga K.
- Organizer
  65th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] The autopsy imaging in Chiba University Hospital2006
- Author(s)
  Azuhata K., Takahashi Y., Kawana H., Higashi M., Ezawa H., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] hMena works as a negative regulator of Racl GTPase at the tip of lamellipodia2006
- Author(s)
  Higashi M., Ishikawa C., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hozumi K., Habu S., Iwama A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  MSBA Forum 2006
- Place of Presentation
  Nagoya
- Year and Date
  2006-12-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] A case of intrahepatic cystadenocarcinoma accompanying proliferative stromal tissue2006
- Author(s)
  Azuhata K., Higashi M., Kawana H., Kondo F., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Roles of hMena in cell morphology and motility2006
- Author(s)
  Higashi M., Mimura C., Azuhata K., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  The 4th Stem Cell Research symposium
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Cloning of a novel short form variant of hMena (Mena-d)2006
- Author(s)
  Azuhata K., Higashi M., Kawana H., Kitagawa M., and Harigaya K.
- Organizer
  65th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2006-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Analysis of effects on Toll-like receptor signaling caused by CD44-deficiency2006
- Author(s)
  Kawana H., Karaki H., Higashi M., Kitagawa M., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Generation of mice deficient in genes for Mastermind-1 and -2, positive regulators for Notch signaling2006
- Author(s)
  Oyama T., Harigaya K., Azuma K., Muradil A., Hirahara K., Yamashita M., Nakayama T., Sakamoto A., Tokuhisa T., Sakamoto R., Sato M., Yoshida N., and Kitagawa M.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Disseminated coccidioidomycosis; A case report2006
- Author(s)
  Azuhata K., Kawana H., Higashi M., and Harigaya K.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-04-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Analysis of recruitment of CD44 to lamellipodia using Fluorescent Recovery After Photobleaching method2006
- Author(s)
  Harigaya K., Umemiya T., Azyma K., Kawana H., and Higashi M.
- Organizer
  The 95th Annual Meeting of Japanese Society of Pathology
- Place of Presentation
  Tokyo
- Year and Date
  2006-05-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590257
[Presentation] Fluorescent Recovery after Photobleaching (FRAP)法を用いたCD44の葉状膜へのrecruitmentの解析2006
- Author(s)
  張ケ谷健一他
- Organizer
  第95回日本病理学会総会
- Place of Presentation
  東京都新宿区
- Year and Date
  2006-05-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590257

1. KITAGAWA Motoo (40262026)

# of Collaborated Projects: 12 results

# of Collaborated Products: 26 results
2. HANDA Hiroshi (80107432)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ISHII Genichiro (00270869)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HIGASHI Morihiro (00323395)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 武内利直 (00167488)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KAWANA Hidetada (80359596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 岸宏久 (90323394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 三方淳男 (40051289)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAMARU Junichi (30188429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 渡辺陽之輔 (20051013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山之端万里

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HARIGAYA Kenichi 張ヶ谷 健一

張ケ谷 健一 ハリガヤ ケンイチ

張ヶ谷 健一 ハリガヤ ケンイチ

Research Projects

Research Products

Co-Researchers

Fragmented hyaluronan is an autocrine factor potentiating cancer cell invasion supported by HAS2 -CD44/hyaluronidase-2 system on the plasma membranePrincipal Investigator

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新規に同定したCD44細胞質内ドメインに会合するタンパク質の機能解析Principal Investigator

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Molecular cloning and function of CD44 cytoplasmic domain associated moleculesPrincipal Investigator

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Molecular Analysis on Tumor Invasion and Metastasis of CD44 Variant FormsPrincipal Investigator

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CD44の細胞運動・転移関連遺伝子発現における役割Principal Investigator

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Study on CD44 molecule in follicular lymphomaPrincipal Investigator

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HARIGAYA Kenichi 張ヶ谷健一

張ケ谷健一ハリガヤケンイチ

張ヶ谷健一ハリガヤケンイチ