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NISHINO Norikazu  西野 憲和

ORCIDConnect your ORCID iD *help
… Alternative Names

西野 憲和  ニシノ ノリカズ

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Researcher Number 40145165
External Links
Affiliation (based on the past Project Information) *help 2012: 九州工業大学, 生命体工学研究科, 教授
2006 – 2009: 九州工業大学, 大学院・生命体工学研究科, 教授
2005: 九州工業大学, 大学院生命体工学研究科, 教授
2001 – 2003: 九州工業大学, 大学院・生命体工学研究科, 教授
1999 – 2002: Kyushu Institute of Technology, Faculty of Engineering, Professor, 工学部, 教授 … More
1997 – 1998: 九州大学, 有機化学基礎研究センター, 教授
1995 – 1996: 九州工業大学, 工学部, 教授
1993: KYUSHU INSTITUTE OF TECHNOLOGY, FACULTY OF ENGINEERING, PROFESSOR, 工学部, 教授
1989 – 1992: 九州工業大学, 工学部, 助教授
1985: 九州工業大学, 工, 助教授 Less
Review Section/Research Field
Principal Investigator
Bioorganic chemistry / 高分子合成 / 高分子合成
Except Principal Investigator
Experimental pathology / 物質生物化学 / Experimental pathology / Surgical dentistry / Biological Sciences
Keywords
Principal Investigator
人工タンパク質 / ポリペプチド / 4α-ヘリックスバンドル構造 / フラビン / 多フッ素化アミノ酸 / 立体構造構築 / βαβα構造体 / ターゲッティング素子 / ポルフィリン / 酵素モデル … More / 触媒機能 / 高次構造 / 疎媒効果 / 両親媒性構造 / エネルギー移動 / Energy Transfer / Free-base Porphyrin / Zn-Porphyrin / L-Lysine / Dendrimers / メチルビオロゲン / 電子移動 / ダンシル基 / トリプトファン / 分子サイズ / フリーベースポルフィリン / 亜鉛ポルフィリン / L-リシン / デンドリマー / Peroxidase / Porphyrin-Fe(III) Complex / Flavin / βαβαStructure / 4α-helix Bundle Structure / Artificial Protein / コラーゲン / アルギニン / βαβα錯体 / ペルオキシダーゼ / ポルフィリン鉄錯体 / βαβα構造 / Growth Hormone Releasing Factor / Biologically Active peptide / Trypsin / Serratia Protease / Protease Catalysis / Peptide Synthesis / ヒト成長ホルモン放出因子 / セラチア56Kプロテア-ゼ / 生理活性ポリペプチド / 成長ホルモン放出因子 / 生理活性ペプチド / トリプシン / セラチアプロテア-ゼ / プロテア-ゼ触媒 / ペプチド合成 / 有機薄膜 / コンホメーション / 合成 / 多環芳香族アミノ酸 / アニリンヒドロキシラーゼ活性 / ペルオキシダーゼモデル / CDスペクトル / RGDS / βαβαポリペプチド / ターゲティング素子 / 抗体認識機能 / 細胞接着性機能 / ポリフィリン / モルテングロビュール / ディノボ設計 / ペルオキシダーゼ活性 / 加水分解活性 / ピレニルアラニン / 構造構築 / 非水系人工タンパク質 / ピレン・インドール・ダンシル / 人工アミノ酸 / 機能性ポリペプチド / ビオロ-ゲン / アントラキノン / ルテニウム・トリスビピリジル錯体 / 光誘起電子移動素子 / αーヘリックス / 機能性ポリペプチドの設計合成 / ビピリジルーペプチド / 二分子膜埋設 / ピケットフェンス型ポルフィリン / ポリペプチドの設計合成 … More
Except Principal Investigator
C5a / 癌 / antagonist / inflammation / transglutaminase / apoptosis / C5a receptor / chemotaxis / leukocyte / ribosomal protein / 光アフィニティ標識 / 走化性 / 多核球 / 単球 / リセプターアンタゴニスト / C5aリセプター / C5aアナフィラトキシン / 白血球走化因子 / S19リボソーム蛋白 / Metalloprotease / Fluorogenic substrate / Synthetic substrate / Metalloendopeptidase / Processing protease / 合成阻害剤 / 蛍光性ペプチド基質 / メタルプロテアーゼ / プロセシング / プロペプチド酵素 / 蛍光基質 / メタルエンドペプチダーゼ / プロセシング酵素 / プロペプチド / ビタミンK依存性凝固因子 / 血栓症 / 受容体 / CD88 / 運動性 / MMP / 産生 / 自己活性化 / フューリン / 受容体拮抗剤 / 阻害剤 / プロテアーゼ / 転移 / 増殖 / 浸潤 / HDACi / DDS / ナノバブル / ソノポレーション / CHAP / HDAC6 / ヒストン脱アセチル化酵素 / SF3b / HDAC阻害剤 / SUMO化酵素 / ヒストンメチル化酵素 / ピストン脱アセチル化酵素 / エピジェネティクス / スプライシング / ドラックデザイン / ケミカルゲノミクス / SUMO化 / メチル化 / アセチル化 / ヒストン Less
  • Research Projects

    (19 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (17 People)
  •  Development of new anticancer drugs and nanobubbles suitable for specific molecular target therapy using sonoporation

    • Principal Investigator
      FUKUDA Jinichi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kyushu Dental College
  •  Investigation and therapeutic application of the cancerauto-activation pathway through generation of anaphylatoxin C5a

    • Principal Investigator
      IMAMURA Takahisa
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  Anticancer drug discovery based on regulation of chromatin structure and function

    • Principal Investigator
      YOSHIDA Minoru
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Hemispherical Synthesis of L-Lysine dendrimers for Clustering of Functional Groups and developing new Functions.Principal Investigator

    • Principal Investigator
      NISHINO Norikazu
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      高分子合成
    • Research Institution
      Kyushu Institute of Technology
  •  人工タンパク質の新規設計による細胞および抗体ターゲッティング機能分子の創製Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu Institute of Technology
  •  Analysis of CS5 co-receptor molecule that specifically inhibits chemotaxis of polymorphonuclear leukocytes

    • Principal Investigator
      YAMAMOTO Tetsuro
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kumamoto University
  •  人工タンパク質の新規設計による細胞および抗体ターゲティング機能分子の創製Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu Institute of Technology
  •  人工タンパク質の新規設計による細胞および抗体ターゲッティング機能分子の創製Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyushu University
  •  Chemical Evolution of De novo Designed Artificial Proteins Incorporating Biological FunctionsPrincipal Investigator

    • Principal Investigator
      NISHINO Norikazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyushu Institute of Technology
      Kyushu University
  •  多フッ素アミノ酸を素構造とする非水系人工タンパク質の設計合成と構造制御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  多フッ素化アミノ酸を素構造とする非水系人工タンパク質の設計合成と構造制御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu Institute of Technology
  •  触媒機能を有するディノボ人工タンパク質の創製は可能か?Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Kyushu University
      Kyushu Institute of Technology
  •  多フッ素化アミノ酸を素構造とする非水系人工タンパク質の設計合成と構造制御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu Institute of Technology
  •  光電子機能を有するポリペプチド性情報変換分子モジュールの組立と機能性御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu Institute of Technology
  •  NEW FLUOROGENIC SYNTHETIC SUBSTRATES AND INHIBITORS FOR MICROSOMAL METALLOENDOPEPTIDASE

    • Principal Investigator
      KAWABATA Shun-ichiro
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      物質生物化学
    • Research Institution
      KYUSHU UNIVERSITY
  •  光電子機能を有するポリペプチド性情報変換分子モデュ-ルの組立と機能制御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu Institute of Technology
  •  光電子機能を有するポリペプチド性情報変換分子モデュ-ルの組立と機能制御Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu Institute of Technology
  •  Synthesis of Biologically Active Polypeptides Mediated by Highly Specific Serratia 56K ProteasePrincipal Investigator

    • Principal Investigator
      NISHINO Norikazu
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      高分子合成
    • Research Institution
      Kyushu Institute of Technology
  •  側鎖機能化アミノ酸による新有機薄膜の合成に関する研究Principal Investigator

    • Principal Investigator
      西野 憲和
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kyushu Institute of Technology

All 2013 2011 2010 2009 2008 2007 2006

All Journal Article Book Patent

  • [Book] HDAC inhibitors : discovery, development, and clinical impacts. In Histone Deacetylases2006

    • Author(s)
      Ito, A., Nishino, N., Yoshida, M
    • Total Pages
      340
    • Publisher
      Humana Press, Totowa New Jersey
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Book] Totowa New Jersey. Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions.2006

    • Author(s)
      Akihiro Ito, Norikazu Nishino, Minoru Yoshida.
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor2013

    • Author(s)
      Fujii, S., Okinaga, T., Ariyoshi, W., Takahashi, O., Iwanaga, K., Nishino, N., Tominaga, K., Nishihara, T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 434 Issue: 3 Pages: 413-20

    • DOI

      10.1016/j.bbrc.2013.03.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390389, KAKENHI-PROJECT-23792377, KAKENHI-PROJECT-24593000, KAKENHI-PROJECT-24659841
  • [Journal Article] Mechanisms of G1 cell cycle arrest and apoptosis in myeloma cells induced by hybrid-compound histone deacetylase inhibitor2013

    • Author(s)
      Fujii, S., Okinaga, T., Ariyoshi, W., Takahashi, O., Iwanaga, K., Nishino, N., Tominaga, K., Nishihara, T
    • Journal Title

      Biochem Biophys Res Commun434

      Volume: 3 Pages: 413-20

    • Data Source
      KAKENHI-PROJECT-22390389
  • [Journal Article] Novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction in oral squamous cell carcinoma2011

    • Author(s)
      Takahashi,O.,Okinaga,T.,Iwanaga,K., Habu,M., Ariyoshi,W.,Tominaga,K. Nishino,N and Nishihara,T
    • Journal Title

      Journal of Biophysical Chemistry

      Volume: Vol.2, No.3 Pages: 215-221

    • Data Source
      KAKENHI-PROJECT-22390389
  • [Journal Article] Bicyclic peptides as potent inhibitors of histone deacetylases: Optimization of alkyl loop length.2010

    • Author(s)
      Islam, N.M., Kato, T., Nishino, N., Kim, H. -J., Ito, A., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. Lett. 20

      Pages: 997-999

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Real-time imaging of histone H4 hyperacetylation in living cells.2009

    • Author(s)
      Sasaki, K., Ito, T., Nishino, N., Khochbin, S., Yoshida, M.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 106

      Pages: 16257-16262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.2008

    • Author(s)
      Nishino, N., Shivashimpi, G.M., Soni, P.B., Bhuiyan, M.P.I., Kato, T., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 437-445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides2008

    • Author(s)
      Nishino, N., et al.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 437-445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] 14-3-3 regulates the nuclear import of class IIa histone deacetylases.2008

    • Author(s)
      Nishino, T.G., Miyazaki, M., Hoshino, H., Miwa, Y., Horinouchi, S., Yoshida, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 852-856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] 14-3-3 regulates the nuclear import of class Iia histone deacetylases2008

    • Author(s)
      Nishino, T. G., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 852-856

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.2007

    • Author(s)
      Shivashimpi, G.M., Amagai, S., Kato, T., Nishino, N., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 15

      Pages: 7830-7839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Corepressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.2007

    • Author(s)
      Hoshino, H., Nishino, T.G., Tashiro, S., Miyazaki, M., Ohmiya, Y., Igarashi, K., Horinouchi, S., Yoshida, M.
    • Journal Title

      J. Biochem. (Tokyo) 141

      Pages: 719-727

    • NAID

      10020099472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.2006

    • Author(s)
      Bhuiyan, M.P., Kato, T., Okauchi, T., Nishino, N., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 3438-3446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Journal Article] Bone morphogenetic protein-2 stimulates Runx2 acetylation.2006

    • Author(s)
      Jeon, E. -J., Lee, K. -Y., Choi, N. -S., Lee, M. -H., Kim, H. -N., Jin, Y. -H., Ryoo, H. -M., Choi, J. -Y., Yoshida, M., Nishino, N., Oh, B. -C., Lee, K. -S., Lee, Y.H., Bae, S. -C.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 16502-16511

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      理化学研究所
    • Acquisition Date
      2010-03-10
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      理化学研究所
    • Acquisition Date
      2010-03-10
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Acquisition Date
      2010-03-10
    • Overseas
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬(ヒストン脱アセチル化酵素の阻害剤およびその製造方法)2007

    • Inventor(s)
      西野憲和、吉田稔、中川純一
    • Industrial Property Rights Holder
      九州工業大学、理化学研究所、大正製薬株式会社
    • Filing Date
      2007-07-31
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬2006

    • Inventor(s)
      西野憲和, 吉田稔, 中川純一
    • Industrial Property Rights Holder
      九工大, 理研, 大正製薬
    • Industrial Property Number
      2006-239901
    • Filing Date
      2006-09-05
    • Data Source
      KAKENHI-PROJECT-17016080
  • [Patent] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬2006

    • Inventor(s)
      西野憲和、吉田稔、中川純一
    • Industrial Property Rights Holder
      九州工業大学、理化学研究所、大正製薬株式会社
    • Industrial Property Number
      2006-239901
    • Filing Date
      2006-09-05
    • Data Source
      KAKENHI-PROJECT-17016080
  • 1.  MIHARA Hisakazu (30183966)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  YOSHIDA Minoru (80191617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 3.  YASHIRODA Yoko (60360658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  YANORI Takao (60200854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  FUKUDA Jinichi (00106270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  IWANAGA Kenjiro (20448484)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  TOMINAGA Kazuhiro (40188793)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  NISHIHARA Tatsuji (80192251)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  HABU Manabu (00360058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  KODAMA Masaaki (40423975)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IMAMURA Takahisa (20176499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  IRIE Atsushi (30250343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KAWABATA Shun-ichiro (90183037)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  IWANAGA Sadaaki (90029942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YAMAMOTO Tetsuro (60112405)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  NAKAYAMA Hitoshi (70088863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SEMBA Umeko (50109691)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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※ この処理は、研究者本人だけが実行できます。

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