komano hiroto 駒野宏人

… Alternative Names

KOMANO HIROTO 駒野宏人

KOMANO Chiaki 駒野宏人

KOMANO Hiroto 駒野宏人

駒野宏人

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Researcher Number	40170378
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 客員教授
Affiliation (based on the past Project Information) *help	2016: 岩手医科大学, 薬学部, 教授 2013: 岩手医科大学, 薬学部, 教授 2011: 岩手医科大学, 薬学部神経科学講座, 教授 2010: 岩手医科大学, 薬学部, 教授 2007 – 2008: Iwate Medical University, 薬学部, 教授 … More 2006: 国立長寿医療センター, 研究所, 室長 2004 – 2006: 国立長寿医療センター, (研究所)・アルツハイマー病研究部, 室長 2004: 国立長寿医療センター, (研究所)・アルツハイマー研究部, 室長 2003: 国立長寿医療センター, アルツハイマー病研究部, 室長 1988 – 1990: Faculty of Pharmaceutical Sciences, University of Tokyo, Assistant Professor, 薬学部, 助手 1986: 東大, 医学部, 助手 1986: 東大, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator Biological pharmacy / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / Biological pharmacy / Medical pharmacy / Nerve anatomy/Neuropathology / Functional biochemistry
Keywords	Principal Investigator 小胞体ストレス / プレセニリン / アミロイドβ蛋白 / アルツハイマー病 / Alzheimer's disease / Homocystein / Presenilin / Amyloid β protein / ER stress / 細胞死 … More / ホモシステイン / 血液脳関門 / ミクログリア / ユビキチン / セクレターゼ … More Except Principal Investigator アルツハイマー病 / アミロイドベータ蛋白 / TNF / アンギオテンシン変換酵素 / Sarcophaga lectin / リセプター / マクロファージ / アミロイド沈着 / アミロイド / アンギオテンシン受容体 / 高血圧症 / Northern blotting / morphogenesis / development / dual functions / defense molecules / imaginal discs / Sarcophaga Peregrina / 昆虫 / 分化 / 成長因子 / 胚細胞 / 発生 / プロテア-ゼ / プロセッシング / 二重機能 / 生体防御蛋白 / 形態形成 / 成虫原基 / ザルコトキシン / ザ-ペシン / ザルコファガレクチン / センチニクバエ / macrophages / 坦癌マウス / 細胞傷害活性 / NHH-Sape-4 / pLE10 / 殺腫瘍因子(TKF) / 腫瘍診断 / 腫瘍壊死因子(TNF) / センチニクバエレクチン / J774.1 / L929 / 細胞傷害性蛋白 / TKF / Aβ43変換活性 / ユビキチン化 / amyloid beta / OS-9 / 小胞体関連分解 / 小胞体 / アミロイドベータ / アルツハイマー / Rer1 / シノビオリン / ニカストリン / プレセニリン複合体 / Aβ三変換活性 / 変換酵素 / 精神・神経疾患の病態と治療 / 脳毛細血管内皮細胞 / 走化性因子 / ATP / 血液脳関 / 接着因子 / 血液脳関門 / DDS / トランスポーター / ドラッグデリバリーシステム / ミクログリア / Aβ分解 / インテグリン / プレセニリン / Aβ変換 / タンパク質分秋 / γセクレターゼ / 細胞応答 / sシグナル伝達 / RIP Less

Regulation of brian amyloid deposition by angiotensin receptor type Ia
- Principal Investigator
  
  ZOU KUN
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Iwate Medical University
Abeta43-converting enzyme and its role in amyloid deposition
- Principal Investigator
  
  ZOU KUN
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Iwate Medical University
The development of new diagnostic and therapeutic tools for AD based on regulation of the gamma-secretase complex assembly.
- Principal Investigator
  
  MAEDA Tomoji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
Clarification of the molecular mechanism underlying the neuronal death induced by ACE inhibition in APP transgenic mouse
- Principal Investigator
  
  ZOU Kun
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Iwate Medical University
Development of brain specific drug delivery system with microglia
- Principal Investigator
  
  MAEDA Tomoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Iwate Medical University
Angiotensin-converting enzyme as an Aβ-degrading and Aβ42-to-Aβ40-converting enzyme
- Principal Investigator
  
  ZOU Kun
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Iwate Medical University
RIPによる細胞内情報伝達機構
- Principal Investigator
  
  鈴木利治
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
血液脳関門を介したミクログリアの脳内移行に関与する分子の同定Principal Investigator
- Principal Investigator
  
  駒野宏人
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
  National Institute for Longevity Sciences,NCGG
Analysis of the role of Herp in the generation of amyloid β protein and in the ER stressPrincipal Investigator
- Principal Investigator
  
  KOMANO Hiroto
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute for Longevity Sciences
アミロイドβ蛋白の産生を制御する因子の同定とその解析Principal Investigator
- Principal Investigator
  
  駒野宏人
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute for Longevity Sciences,NCGG
Studies on the Dual Functions of Defense Molecules
- Principal Investigator
  
  NATORI Shunji
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo
マクロファージ様株化細胞J774・1が産生する腫瘍傷害性蛋白の研究
- Principal Investigator
  
  NATORI Shunji
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Development of convenient method to diagnose tumor by use of Sarcophaga lectin
- Principal Investigator
  
  NATORI Shunji
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Tokyo

All 2016 2015 2014 2013 2012 2011 2010 2008 2007 Other

All Journal Article Presentation

[Journal Article] Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.2015
- Author(s)
  Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, Tanabe C, Maeda T, Michikawa M, Komano H, Zou K.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 12059-12059
- DOI
  10.1038/srep12059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461375, KAKENHI-PROJECT-26430057, KAKENHI-PROJECT-15K15712
[Journal Article] Differential effects of angiotensin II receptor blockers on Aβgeneration2014
- Author(s)
  Liu, J., Liu, S., Tanabe, C., Maeda, T., Zou, K., Komano, H.
- Journal Title
  
  Neurosci Lett
  
  Volume: 567 Pages: 51-56
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2014
- Author(s)
  Shuyu Liu, Junjun Liu, Yukie Miura, Chiaki Tanabe, Tomoji Maeda, Yasuo Terayama, Anthony J. Turner, Kun Zou, Hiroto Komano
- Journal Title
  
  J Neurosci Res.
  
  Volume: 92 Issue: 9 Pages: 1178-1186
- DOI
  10.1002/jnr.23404
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430057
[Journal Article] ifferential effects of angiotensin II receptor blockers on Aβ generation.2014
- Author(s)
  Liu J, Liu S, Tanabe C, Maeda T, Zou K, Komano H
- Journal Title
  
  Neurosci Lett
  
  Volume: 567 Pages: 51-56
- DOI
  10.1016/j.neulet.2014.03.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2014
- Author(s)
  Liu S, Liu J, Miura Y, Tanabe C, Maeda T, Terayama Y, Turner AJ, Zou K, Komano H
- Journal Title
  
  J Neurosci Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme2014
- Author(s)
  Liu, S., Liu, J., Miura, Y., Tanabe, C., Maeda, T., Terayama, Y., Turner, A.J., Zou, K., Komano, H.
- Journal Title
  
  J Neurosci Res
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.2013
- Author(s)
  Zou K, Liu J, Watanabe A, Hiraga S, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Issue: 6 Pages: 2311-2331
- DOI
  10.1016/j.ajpath.2013.01.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700383, KAKENHI-PROJECT-25461375
[Journal Article] Aβ43 is the earliest depositing Aβspecies in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2013
- Author(s)
  Zou, K., Liu, J., Watanabe, A., Hiraga, S., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., Komano, H.
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 2311-2331
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.2012
- Author(s)
  Tanabe C, Maeda T, Zou K, Liu J, Liu S, Nakajima T, Komano H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 53 Pages: 44203-44211
- DOI
  10.1074/jbc.m112.365296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590110, KAKENHI-PROJECT-23659176, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-24700383
[Journal Article] The ubiquitin ligase synoviolin up-regulates amyloidβproduction by targeting a negative regulator ofγ-secretase, Rer 1, for degradation2012
- Author(s)
  Tanabe, C., Maeda, T., Zou, K., Liu, J., Liu, S., Nakajima, T., Komano, H.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 28 Pages: 44203-44211
- Data Source
  KAKENHI-PROJECT-24700383
[Journal Article] Differential appearance of serum Aβ43 and Aβ42 in the patients with Alzheimer's disease2011
- Author(s)
  Zou K, Liu S, Liu J, Tanabe C, Maeda T, Terayama Y, Takahashi S and Komano H
- Journal Title
  
  Translational Medic
  
  Volume: 1 Pages: 103-103
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] Differential appearance of serum Aβ43 and Aβ42 in the patients with Alzheimer's disease2011
- Author(s)
  Kun Zou, Shuyu Liu, Junjun Liu, Chiaki Tanabe, Tomoji Maeda, Yasuo Terayama, Satoshi Takahashi, Hiroto Komano
- Journal Title
  
  Translational Medicine
  
  Volume: 1 Issue: 03 Pages: 3-4
- DOI
  10.4172/2161-1025.1000103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin2011
- Author(s)
  Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M and Komano H
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1810 Pages: 790-798
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin2011
- Author(s)
  Toshihiro Marutani, Tomoji Maeda, Chiaki Tanabe, Kun Zou, Wataru Araki, Koichi Kokame, Makoto Michikawa, Hiroto Komano
- Journal Title
  
  Biochimica et Biophysica Acta
  
  Volume: 1810 Pages: 790-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] アンギオテンシン変換酵素の新しい顔:Aβ変換酵素2010
- Author(s)
  鄒鶤、道川誠、駒野宏人
- Journal Title
  
  生化学
  
  Volume: 第八十二巻 Pages: 1120-1124
- NAID
  10027880213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] A novel Aβ-converting activity of angiotensin-converting enzyme and its role in Alzheimer's disease2010
- Author(s)
  Zou K., Michikawa M. and Komano H
- Journal Title
  
  Seikagaku
  
  Volume: 82 Pages: 1120-1124
- NAID
  10027880213
- Data Source
  KAKENHI-PROJECT-22700399
[Journal Article] Novel role of presenilins in maturation and transport of integrin β1.2008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa and Makoto Michikawa
- Journal Title
  
  Biochemishy 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Novel role of presenilins in maturation and transport of integrinβ1.2008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa, Makoto Michikawa
- Journal Title
  
  Biochemistry 27
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] New amyloid plaques or a game of hide-and-seek2008
- Author(s)
  Kun, Zou, Tomoji, Maeda, Makoto, Michikawa and Hiroto, Komano
- Journal Title
  
  Int J Biol Sci 4
  
  Pages: 200-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] Novel role of presenilins in maturation and transport of integrin β12008
- Author(s)
  Zou K., Hosono T., Nakamura T., Shiraishi H., Maeda T., Komano H., Yanagisawa K., Michikawa M
- Journal Title
  
  Biochemistry (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659026
[Journal Article] Novel role of presenilins in maturation and transport of integrin beta12008
- Author(s)
  Kun Zou, Takashi Hosono, Toshiyuki Nakamura, Hirohisa Shiraishi, Tomoji Maeda, Hiroto Komano, Katsuhiko Yanagisawa and Makoto Michikawa
- Journal Title
  
  Biochemistry 47
  
  Pages: 3370-3378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Journal Article] A family of membrane proteins associated with presenilin expression and γ-secretase function2008
- Author(s)
  Araki W., Takahashi-Sasaki N., Chui DH., Saito S., Takeda K., Shirotani K., Takahashi K., Murayama KS., Kametani F., Shiraishi H., Komano H., Tabira T.
- Journal Title
  
  FASEB J. 22
  
  Pages: 819-827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17659026
[Journal Article] New amyloid plaques or a game of hide-and-seek.2008
- Author(s)
  Kun Zou, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Journal Title
  
  International Journal of Biological Sciences 4
  
  Pages: 200-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800040
[Presentation] ACE deficiency increases amyloid　plaque burden in APP transgenic mouse brain2016
- Author(s)
  鄒鶤、劉しゅ余、劉俊俊、松元葵、沈雪峰、横森未来、下方浩史、道川誠、駒野宏人
- Organizer
  第35回日本認知症学会学術集会　東京 2016年12月1日
- Place of Presentation
  東京都
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Differential effects of angiotensin II receptor blockers on Aβ generation2015
- Author(s)
  劉俊俊、劉しゅう余、村上咲、菅川悠介、賀美綾子、田邊千晶、前田智司、鄒鶤、駒野宏人
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type 1a receptor deficiency decreases amyloid β-protein production and ameliorates brain amyloid pathology2015
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Yusuke Sugakawa, Ayako Kami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  25th Meeting of The International Society For Neurochemistry
- Place of Presentation
  Cairns, Australia
- Year and Date
  2015-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type 1a receptor deficiency ameliorates brain amyloid pathology by regulating γ-secretase complex formation2015
- Author(s)
  Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Yusuke Sugakawa, Ayako Kami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano, Kun Zou
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  矢巾町
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] レニン・アンギオテンシン系とAβ除去2015
- Author(s)
  鄒鶤、駒野宏人
- Organizer
  第34回日本認知症学会学術集会　シンポジウム
- Place of Presentation
  青森市
- Year and Date
  2015-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] アンギオテンシン受容体によるアミロイドβ蛋白産生制御2015
- Author(s)
  駒野宏人、鄒鶤
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学大会合同大会ワークショップ
- Place of Presentation
  神戸市
- Year and Date
  2015-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Angiotensin type Ia receptor deficiency ameliorates amyloid plaque formation.2013
- Author(s)
  Zou K, Liu J, Liu S, Matsumoto Y, Tanabe C, Maeda T, Michikawa M, Komano H
- Organizer
  23rd Alzheimer Europe Conference
- Place of Presentation
  Malta
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Angiotensin type Ia receptor regulates amyloid plaque formation.2013
- Author(s)
  鄒鶤，劉俊俊，劉姝余，松本幸乃，村上咲，田邉千晶，前田智司，道川誠，駒野宏人
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Angiotensin II type Ia receptor deficiency ameliorates brain amyloid pathology in a transgenic mouse model of Alzheimer’s disease.2013
- Author(s)
  Liu J, Liu S, Matsumoto Y, Tanabe C, Maeda T, Zou K, Komano H
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] The stability of endoplasmic stress-inducible Herp is regulated by synoviolin-mediated and ubiquitin-independent proteasomal degradation2013
- Author(s)
  前田智司、田邉千晶、鄒鶤、鈴木ひとみ、稲垣学人、劉俊俊、劉しゅ余、駒野宏人
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Conversion of Aβ43 to Aβ40 by combination of angiotensin-converting enzyme 2 and angiotensin-converting enzyme.2013
- Author(s)
  Liu S, Liu J, Miura Y, Tanabe C, Maeda T, Terayama Y, Turner AJ, Zou K, Komano H
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Analysis of Aβ42-to-Aβ40-converting activity and Aβ43 level in AD patient serum2012
- Author(s)
  Liu S ○, Liu J, Tanabe C, Maeda T, Terayama Y, Takahashi S, Zou K, Komano H
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Early deposition of Aβ43 in APP transgenic mouse brain2012
- Author(s)
  鄒鶤○,劉俊俊,渡邉淳，劉姝余, 田邉千晶,前田智司,寺山靖夫，高橋智，道川誠，駒野宏人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  筑波市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] アルツハイマー病モデルマウスにおけるAβ43の脳内蓄積の解析2012
- Author(s)
  劉姝余,劉俊俊,平賀彩江子,松本幸乃,三浦友希恵,田邉千晶,前田智司,鄒鶤,駒野宏人
- Organizer
  日本生化学会東北支部第78回例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2012
- Author(s)
  Zou K ○, Liu J, Watanabe A, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Analysis of Aβ42-to-Aβ40- converting activity and Aβ43 level in AD patient serum2012
- Author(s)
  Liu, S., Liu, J., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Zou, K., Komano, H.
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] 小胞体ストレス誘導タンパク質Herp の分解機構の解析2012
- Author(s)
  鈴木ひとみ, 稲垣学人, 田邉千晶, 鄒鶤, 劉俊俊, 劉姝余, 小亀浩市, 前田智司, 駒野宏人
- Organizer
  日本生化学会東北支部　第78回　例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] アルツハイマー病モデルマウスにおけるAβ43 の脳内蓄積の解析2012
- Author(s)
  劉姝余, 劉俊俊, 平賀彩江子○, 松本幸乃, 三浦友希恵,田邉千晶, 前田智司, 鄒鶤, 駒野宏人
- Organizer
  日本生化学会東北支部　第78回　例会・シンポジウム
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] 小胞体ストレス誘導タンパク質Herpの分解機構の解析2012
- Author(s)
  鈴木ひとみ、稲垣学人、田邉千晶、鄒鶤、Junjun Liu、Shuyu Liu、小亀浩一、前田智司、駒野宏人
- Organizer
  日本生化学会東北支部第78回例会・シンポジウム
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Early deposition of Aβ43 in APP transgenic mouse brain2012
- Author(s)
  鄒鶤,劉俊俊,渡邉淳,劉姝余,田邉千晶,前田智司,寺山靖夫,高橋智,道川誠,駒野宏人
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  筑波
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Aβ43 is the earliest depositing Aβspecies in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE2012
- Author(s)
  Zou, K., Liu, J., Watanabe, A., Liu, S., Tanabe, C., Maeda, T., Terayama, Y., Takahashi, S., Michikawa, M., Komano, H.
- Organizer
  第11回アジア太平洋神経化学会・第55回日本神経化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24700383
[Presentation] Two active domains of ACE are essential for Aβ43-converting activity2011
- Author(s)
  鄒鶤、劉俊俊、渡邉淳、劉殊余、田邉千晶、前田智司、大葉龍太郎、道川誠、駒野宏人
- Organizer
  第23回国際神経化学会国際会議
- Place of Presentation
  アテネ
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Synoviolin facilitates the degradation of an ER-stress-inducible protein, Herp2011
- Author(s)
  前田智司、田邉千晶、鄒鶤、劉俊俊、劉しゅ余、小亀浩市、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Synoviolin is involved in the degradation of Rer1, thereby modulating Amyloid beta2011
- Author(s)
  田邉千晶、前田智司、鄒鶤、劉俊俊、劉しゅ余、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Aβ343変換活性におけるACEの二つ活性ドメインの役割2011
- Author(s)
  鄒鶤、劉俊俊、劉妹余、田邉千晶、前田智司、渡邉淳、道川誠、駒野宏人
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  石川県加賀市
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Synoviolin facilitates the degradation of an ER-stress-inducible protein, Herp.2011
- Author(s)
  前田智司、田邉千晶、鄒鶤、小亀浩市、駒野宏人
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590110
[Presentation] Aβ43変換活性におけるACEの二つ活性ドメインの役割2011
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、渡邉淳、道川誠、駒野宏人
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  石川県加賀市
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Two active domains of ACE are essential for Aβ43-converting activity2011
- Author(s)
  Kun Zou, Junjun Liu, Atsushi, Watanabe, Shuyu Liu, Chiaki tanabe, Tomoji Maeda, Ryutaro Oba, Makoto Michikawa, Hiroto Komano
- Organizer
  23^<rd> Biennial Meeting of International Society for Neuro chemistry
- Place of Presentation
  Athens, Greece
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] ACE阻害によるアルツハイマー病モデルマウス脳内変化の解析2010
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第53回日本神経化学学会、第33回日本神経科学大会、第20回日本神経回路学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain.2010
- Author(s)
  Kun Zou, Shuyu Liu, Junjun Liu, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Enhanced Alzheimer's-like pathology by ACE inhibition in APP transgenic mouse brain.2010
- Author(s)
  鄒鶤、劉俊俊、劉〓余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Potent inhibition of ACE leads to Alzheimer-like pathology in APP transgenic mouse brain2010
- Author(s)
  鄒鶤、劉殊余、劉俊俊、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  2010年国際アルツハイマー病協会国際会議
- Place of Presentation
  ホノルル
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] ACE阻害によるアルツハイマー病モデルマウス脳内変化の解析2010
- Author(s)
  鄒鶤、劉俊俊、劉〓余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第53回日本神経化学学会、第33回日本神経科学大会、第20回日本神経回路学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Enhanced Alzheimer's-like pathology by ACE inhibition in APP transgenic mouse brain2010
- Author(s)
  鄒鶤、劉俊俊、劉殊余、田邉千晶、前田智司、道川誠、駒野宏人
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22700399
[Presentation] Herpによるプレセニリン(PS)複合体形成制御機構について2007
- Author(s)
  丸谷寿裕、前田智司、小亀浩一、鄒鶤、道川誠、駒野宏人
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-17659026
[Presentation] Angiotensin-Converting Enzyme Converts A β 1-42 to A β 1-40, and Its Inhibition enhances Brain A β deposition.2007
- Author(s)
  鄒鶤、山口晴保、赤津裕康、阪本崇彰、高美姫、溝口和臣、キョウ建生、于文新、山本孝之、小阪憲司、駒野宏人、柳沢勝彦、道川誠
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-17659026
[Presentation] Angiotensin type 1a receptor deficiency attenuates amyloid beta-protein production and ameliorates brain amyloid pathology.
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] アンギオテンシン受容体による脳内アミロイド蓄積制御機構の解明.
- Author(s)
  Kun Zou, Junjun Liu, Shuyu Liu, Yukino Matsumoto, Saki Murakami, Chiaki Tanabe, Tomoji Maeda, Makoto Michikawa, Hiroto Komano
- Organizer
  第57回日本神経化学会大会
- Place of Presentation
  奈良市
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-26430057
[Presentation] Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme-2 and angiotensin-converting enzyme.
- Author(s)
  Shuyu Liu, Kun Zou, Junjun Liu, Yu Fujita, Tomoji Maeda, Yasuo Terayama, Anthony J. Turner, Hiroto Komano
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26430057

1. ZOU Kun (40450837)

# of Collaborated Projects: 4 results

# of Collaborated Products: 50 results
2. MAEDA Tomoji (60303294)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. NATORI Shunji (50012662)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MICHIKAWA Makoto (40270912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. TANABE Chiaki (00552902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 鈴木利治 (80179233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森島真帆 (50204722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 矢部大介 (60378643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西村正樹 (40322739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石浦章一 (10158743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 上野孝治 (10143504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中西義信 (40172358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 菅野能範

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHINORI Sugano

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 堂前純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

komano hiroto 駒野 宏人

KOMANO HIROTO 駒野 宏人

KOMANO Chiaki 駒野 宏人

KOMANO Hiroto 駒野 宏人

駒野 宏人

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血液脳関門を介したミクログリアの脳内移行に関与する分子の同定Principal Investigator

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Analysis of the role of Herp in the generation of amyloid β protein and in the ER stressPrincipal Investigator

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アミロイドβ蛋白の産生を制御する因子の同定とその解析Principal Investigator

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[Journal Article] Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.2015

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komano hiroto 駒野宏人

KOMANO HIROTO 駒野宏人

KOMANO Chiaki 駒野宏人

KOMANO Hiroto 駒野宏人

駒野宏人